data_4JO1
# 
_entry.id   4JO1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.379 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   4JO1         pdb_00004jo1 10.2210/pdb4jo1/pdb 
RCSB  RCSB078287   ?            ?                   
WWPDB D_1000078287 ?            ?                   
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.db_id 
_pdbx_database_related.details 
_pdbx_database_related.content_type 
PDB 4JO2 . unspecified 
PDB 4JO3 . unspecified 
PDB 4JO4 . unspecified 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.entry_id                        4JO1 
_pdbx_database_status.recvd_initial_deposition_date   2013-03-16 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.status_code_nmr_data            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
'Pan, R.M.'  1 
'Kong, X.P.' 2 
# 
_citation.id                        primary 
_citation.title                     
;Rabbit Anti-HIV-1 Monoclonal Antibodies Raised by Immunization Can Mimic the Antigen-Binding Modes of Antibodies Derived from HIV-1-Infected Humans.
;
_citation.journal_abbrev            J.Virol. 
_citation.journal_volume            87 
_citation.page_first                10221 
_citation.page_last                 10231 
_citation.year                      2013 
_citation.journal_id_ASTM           JOVIAM 
_citation.country                   US 
_citation.journal_id_ISSN           0022-538X 
_citation.journal_id_CSD            0825 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   23864637 
_citation.pdbx_database_id_DOI      10.1128/JVI.00843-13 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pan, R.'       1 ? 
primary 'Sampson, J.M.' 2 ? 
primary 'Chen, Y.'      3 ? 
primary 'Vaine, M.'     4 ? 
primary 'Wang, S.'      5 ? 
primary 'Lu, S.'        6 ? 
primary 'Kong, X.P.'    7 ? 
# 
_cell.entry_id           4JO1 
_cell.length_a           70.514 
_cell.length_b           74.347 
_cell.length_c           84.438 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.01 
_cell.angle_gamma        90.00 
_cell.Z_PDB              4 
_cell.pdbx_unique_axis   ? 
_cell.length_a_esd       ? 
_cell.length_b_esd       ? 
_cell.length_c_esd       ? 
_cell.angle_alpha_esd    ? 
_cell.angle_beta_esd     ? 
_cell.angle_gamma_esd    ? 
# 
_symmetry.entry_id                         4JO1 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'monoclonal anti-HIV-1 gp120 V3 antibody R56 light chain' 22782.014 2   ? ? Fab ? 
2 polymer     man 'monoclonal anti-HIV-1 gp120 V3 antibody R56 heavy chain' 22173.852 2   ? ? Fab ? 
3 polymer     man gp120                                                     2506.816  2   ? ? 
'third variable region (V3) crown (UNP residues 32-54)' ? 
4 non-polymer syn 'CALCIUM ION'                                             40.078    5   ? ? ? ? 
5 water       nat water                                                     18.015    805 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;QVLTQTPSSVSTAVGSAVTINCQSSQNVYSNNNLAWFQQKPGQPPRLLIYDASKLASGVPSRFKGSGSGTQFTFTISDVQ
CDDAATFYCLGGYDCSSGDCAAFGGGTEVVVRGDPVAPTVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQT
TGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFNRGDC
;
;QVLTQTPSSVSTAVGSAVTINCQSSQNVYSNNNLAWFQQKPGQPPRLLIYDASKLASGVPSRFKGSGSGTQFTFTISDVQ
CDDAATFYCLGGYDCSSGDCAAFGGGTEVVVRGDPVAPTVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQT
TGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFNRGDC
;
L,M ? 
2 'polypeptide(L)' no no 
;QSLEESGGDLVQPGASLTLTCKASGFSFGNNYDMCWVRQAPGKGLEWIGCIETGSSDSAAYATWAKGRFTISKTSSTTVT
LQMTSLTAADTATYFCARNFDLWGPGTLVIVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLT
NGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTC
;
;QSLEESGGDLVQPGASLTLTCKASGFSFGNNYDMCWVRQAPGKGLEWIGCIETGSSDSAAYATWAKGRFTISKTSSTTVT
LQMTSLTAADTATYFCARNFDLWGPGTLVIVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLT
NGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTC
;
H,I ? 
3 'polypeptide(L)' no no NNTRKSIHIGPGRAFYTTGEIIG NNTRKSIHIGPGRAFYTTGEIIG P,Q ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   VAL n 
1 3   LEU n 
1 4   THR n 
1 5   GLN n 
1 6   THR n 
1 7   PRO n 
1 8   SER n 
1 9   SER n 
1 10  VAL n 
1 11  SER n 
1 12  THR n 
1 13  ALA n 
1 14  VAL n 
1 15  GLY n 
1 16  SER n 
1 17  ALA n 
1 18  VAL n 
1 19  THR n 
1 20  ILE n 
1 21  ASN n 
1 22  CYS n 
1 23  GLN n 
1 24  SER n 
1 25  SER n 
1 26  GLN n 
1 27  ASN n 
1 28  VAL n 
1 29  TYR n 
1 30  SER n 
1 31  ASN n 
1 32  ASN n 
1 33  ASN n 
1 34  LEU n 
1 35  ALA n 
1 36  TRP n 
1 37  PHE n 
1 38  GLN n 
1 39  GLN n 
1 40  LYS n 
1 41  PRO n 
1 42  GLY n 
1 43  GLN n 
1 44  PRO n 
1 45  PRO n 
1 46  ARG n 
1 47  LEU n 
1 48  LEU n 
1 49  ILE n 
1 50  TYR n 
1 51  ASP n 
1 52  ALA n 
1 53  SER n 
1 54  LYS n 
1 55  LEU n 
1 56  ALA n 
1 57  SER n 
1 58  GLY n 
1 59  VAL n 
1 60  PRO n 
1 61  SER n 
1 62  ARG n 
1 63  PHE n 
1 64  LYS n 
1 65  GLY n 
1 66  SER n 
1 67  GLY n 
1 68  SER n 
1 69  GLY n 
1 70  THR n 
1 71  GLN n 
1 72  PHE n 
1 73  THR n 
1 74  PHE n 
1 75  THR n 
1 76  ILE n 
1 77  SER n 
1 78  ASP n 
1 79  VAL n 
1 80  GLN n 
1 81  CYS n 
1 82  ASP n 
1 83  ASP n 
1 84  ALA n 
1 85  ALA n 
1 86  THR n 
1 87  PHE n 
1 88  TYR n 
1 89  CYS n 
1 90  LEU n 
1 91  GLY n 
1 92  GLY n 
1 93  TYR n 
1 94  ASP n 
1 95  CYS n 
1 96  SER n 
1 97  SER n 
1 98  GLY n 
1 99  ASP n 
1 100 CYS n 
1 101 ALA n 
1 102 ALA n 
1 103 PHE n 
1 104 GLY n 
1 105 GLY n 
1 106 GLY n 
1 107 THR n 
1 108 GLU n 
1 109 VAL n 
1 110 VAL n 
1 111 VAL n 
1 112 ARG n 
1 113 GLY n 
1 114 ASP n 
1 115 PRO n 
1 116 VAL n 
1 117 ALA n 
1 118 PRO n 
1 119 THR n 
1 120 VAL n 
1 121 LEU n 
1 122 ILE n 
1 123 PHE n 
1 124 PRO n 
1 125 PRO n 
1 126 ALA n 
1 127 ALA n 
1 128 ASP n 
1 129 GLN n 
1 130 VAL n 
1 131 ALA n 
1 132 THR n 
1 133 GLY n 
1 134 THR n 
1 135 VAL n 
1 136 THR n 
1 137 ILE n 
1 138 VAL n 
1 139 CYS n 
1 140 VAL n 
1 141 ALA n 
1 142 ASN n 
1 143 LYS n 
1 144 TYR n 
1 145 PHE n 
1 146 PRO n 
1 147 ASP n 
1 148 VAL n 
1 149 THR n 
1 150 VAL n 
1 151 THR n 
1 152 TRP n 
1 153 GLU n 
1 154 VAL n 
1 155 ASP n 
1 156 GLY n 
1 157 THR n 
1 158 THR n 
1 159 GLN n 
1 160 THR n 
1 161 THR n 
1 162 GLY n 
1 163 ILE n 
1 164 GLU n 
1 165 ASN n 
1 166 SER n 
1 167 LYS n 
1 168 THR n 
1 169 PRO n 
1 170 GLN n 
1 171 ASN n 
1 172 SER n 
1 173 ALA n 
1 174 ASP n 
1 175 CYS n 
1 176 THR n 
1 177 TYR n 
1 178 ASN n 
1 179 LEU n 
1 180 SER n 
1 181 SER n 
1 182 THR n 
1 183 LEU n 
1 184 THR n 
1 185 LEU n 
1 186 THR n 
1 187 SER n 
1 188 THR n 
1 189 GLN n 
1 190 TYR n 
1 191 ASN n 
1 192 SER n 
1 193 HIS n 
1 194 LYS n 
1 195 GLU n 
1 196 TYR n 
1 197 THR n 
1 198 CYS n 
1 199 LYS n 
1 200 VAL n 
1 201 THR n 
1 202 GLN n 
1 203 GLY n 
1 204 THR n 
1 205 THR n 
1 206 SER n 
1 207 VAL n 
1 208 VAL n 
1 209 GLN n 
1 210 SER n 
1 211 PHE n 
1 212 ASN n 
1 213 ARG n 
1 214 GLY n 
1 215 ASP n 
1 216 CYS n 
2 1   GLN n 
2 2   SER n 
2 3   LEU n 
2 4   GLU n 
2 5   GLU n 
2 6   SER n 
2 7   GLY n 
2 8   GLY n 
2 9   ASP n 
2 10  LEU n 
2 11  VAL n 
2 12  GLN n 
2 13  PRO n 
2 14  GLY n 
2 15  ALA n 
2 16  SER n 
2 17  LEU n 
2 18  THR n 
2 19  LEU n 
2 20  THR n 
2 21  CYS n 
2 22  LYS n 
2 23  ALA n 
2 24  SER n 
2 25  GLY n 
2 26  PHE n 
2 27  SER n 
2 28  PHE n 
2 29  GLY n 
2 30  ASN n 
2 31  ASN n 
2 32  TYR n 
2 33  ASP n 
2 34  MET n 
2 35  CYS n 
2 36  TRP n 
2 37  VAL n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLY n 
2 45  LEU n 
2 46  GLU n 
2 47  TRP n 
2 48  ILE n 
2 49  GLY n 
2 50  CYS n 
2 51  ILE n 
2 52  GLU n 
2 53  THR n 
2 54  GLY n 
2 55  SER n 
2 56  SER n 
2 57  ASP n 
2 58  SER n 
2 59  ALA n 
2 60  ALA n 
2 61  TYR n 
2 62  ALA n 
2 63  THR n 
2 64  TRP n 
2 65  ALA n 
2 66  LYS n 
2 67  GLY n 
2 68  ARG n 
2 69  PHE n 
2 70  THR n 
2 71  ILE n 
2 72  SER n 
2 73  LYS n 
2 74  THR n 
2 75  SER n 
2 76  SER n 
2 77  THR n 
2 78  THR n 
2 79  VAL n 
2 80  THR n 
2 81  LEU n 
2 82  GLN n 
2 83  MET n 
2 84  THR n 
2 85  SER n 
2 86  LEU n 
2 87  THR n 
2 88  ALA n 
2 89  ALA n 
2 90  ASP n 
2 91  THR n 
2 92  ALA n 
2 93  THR n 
2 94  TYR n 
2 95  PHE n 
2 96  CYS n 
2 97  ALA n 
2 98  ARG n 
2 99  ASN n 
2 100 PHE n 
2 101 ASP n 
2 102 LEU n 
2 103 TRP n 
2 104 GLY n 
2 105 PRO n 
2 106 GLY n 
2 107 THR n 
2 108 LEU n 
2 109 VAL n 
2 110 ILE n 
2 111 VAL n 
2 112 SER n 
2 113 SER n 
2 114 GLY n 
2 115 GLN n 
2 116 PRO n 
2 117 LYS n 
2 118 ALA n 
2 119 PRO n 
2 120 SER n 
2 121 VAL n 
2 122 PHE n 
2 123 PRO n 
2 124 LEU n 
2 125 ALA n 
2 126 PRO n 
2 127 CYS n 
2 128 CYS n 
2 129 GLY n 
2 130 ASP n 
2 131 THR n 
2 132 PRO n 
2 133 SER n 
2 134 SER n 
2 135 THR n 
2 136 VAL n 
2 137 THR n 
2 138 LEU n 
2 139 GLY n 
2 140 CYS n 
2 141 LEU n 
2 142 VAL n 
2 143 LYS n 
2 144 GLY n 
2 145 TYR n 
2 146 LEU n 
2 147 PRO n 
2 148 GLU n 
2 149 PRO n 
2 150 VAL n 
2 151 THR n 
2 152 VAL n 
2 153 THR n 
2 154 TRP n 
2 155 ASN n 
2 156 SER n 
2 157 GLY n 
2 158 THR n 
2 159 LEU n 
2 160 THR n 
2 161 ASN n 
2 162 GLY n 
2 163 VAL n 
2 164 ARG n 
2 165 THR n 
2 166 PHE n 
2 167 PRO n 
2 168 SER n 
2 169 VAL n 
2 170 ARG n 
2 171 GLN n 
2 172 SER n 
2 173 SER n 
2 174 GLY n 
2 175 LEU n 
2 176 TYR n 
2 177 SER n 
2 178 LEU n 
2 179 SER n 
2 180 SER n 
2 181 VAL n 
2 182 VAL n 
2 183 SER n 
2 184 VAL n 
2 185 THR n 
2 186 SER n 
2 187 SER n 
2 188 SER n 
2 189 GLN n 
2 190 PRO n 
2 191 VAL n 
2 192 THR n 
2 193 CYS n 
2 194 ASN n 
2 195 VAL n 
2 196 ALA n 
2 197 HIS n 
2 198 PRO n 
2 199 ALA n 
2 200 THR n 
2 201 ASN n 
2 202 THR n 
2 203 LYS n 
2 204 VAL n 
2 205 ASP n 
2 206 LYS n 
2 207 THR n 
2 208 VAL n 
2 209 ALA n 
2 210 PRO n 
2 211 SER n 
2 212 THR n 
2 213 CYS n 
3 1   ASN n 
3 2   ASN n 
3 3   THR n 
3 4   ARG n 
3 5   LYS n 
3 6   SER n 
3 7   ILE n 
3 8   HIS n 
3 9   ILE n 
3 10  GLY n 
3 11  PRO n 
3 12  GLY n 
3 13  ARG n 
3 14  ALA n 
3 15  PHE n 
3 16  TYR n 
3 17  THR n 
3 18  THR n 
3 19  GLY n 
3 20  GLU n 
3 21  ILE n 
3 22  ILE n 
3 23  GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample ? ? ? rabbit ? ?   ? ? ? ? ? ? 'Oryctolagus cuniculus'          9986  ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample ? ? ? rabbit ? ?   ? ? ? ? ? ? 'Oryctolagus cuniculus'          9986  ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample ? ? ? HIV-1  ? env ? ? ? ? ? ? 'Human immunodeficiency virus 1' 11676 ? ? ? ? ? ? ? ?     ?              ?    ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
_struct_ref.pdbx_db_isoform 
1 UNP Q9YX36_9HIV1 Q9YX36 3 NNTRKSIHIGPGRAFYTTGEIIG 32 ? 
2 PDB 4JO1         4JO1   1 
;QVLTQTPSSVSTAVGSAVTINCQSSQNVYSNNNLAWFQQKPGQPPRLLIYDASKLASGVPSRFKGSGSGTQFTFTISDVQ
CDDAATFYCLGGYDCSSGDCAAFGGGTEVVVRGDPVAPTVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQT
TGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFNRGDC
;
1  ? 
3 PDB 4JO1         4JO1   2 
;QSLEESGGDLVQPGASLTLTCKASGFSFGNNYDMCWVRQAPGKGLEWIGCIETGSSDSAAYATWAKGRFTISKTSSTTVT
LQMTSLTAADTATYFCARNFDLWGPGTLVIVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLT
NGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTC
;
1  ? 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 4JO1 P 1 ? 23  ? Q9YX36 32 ? 54  ? 301 325 
2 1 4JO1 Q 1 ? 23  ? Q9YX36 32 ? 54  ? 301 325 
3 2 4JO1 L 1 ? 216 ? 4JO1   2  ? 211 ? 2   211 
4 2 4JO1 M 1 ? 216 ? 4JO1   2  ? 211 ? 2   211 
5 3 4JO1 H 1 ? 213 ? 4JO1   2  ? 213 ? 2   213 
6 3 4JO1 I 1 ? 213 ? 4JO1   2  ? 213 ? 2   213 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ? 'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
_exptl.entry_id          4JO1 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.33 
_exptl_crystal.density_percent_sol   47.25 
_exptl_crystal.description           ? 
_exptl_crystal.F_000                 ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.temp            296 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pH              8.0 
_exptl_crystal_grow.pdbx_details    
'26% PEG6000, 1 M lithium chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296K' 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.ambient_temp_details   ? 
_diffrn.crystal_id             1 
# 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.detector               CCD 
_diffrn_detector.type                   'ADSC QUANTUM 270' 
_diffrn_detector.pdbx_collection_date   2010-06-06 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.monochromator                    'channel cut Si(111)' 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'NSLS BEAMLINE X6A' 
_diffrn_source.pdbx_synchrotron_site       NSLS 
_diffrn_source.pdbx_synchrotron_beamline   X6A 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_wavelength_list        1.0 
# 
_reflns.entry_id                     4JO1 
_reflns.observed_criterion_sigma_I   0 
_reflns.observed_criterion_sigma_F   0 
_reflns.d_resolution_low             36.226 
_reflns.d_resolution_high            2.033 
_reflns.number_obs                   56014 
_reflns.number_all                   56059 
_reflns.percent_possible_obs         99.5 
_reflns.pdbx_Rmerge_I_obs            0.074 
_reflns.pdbx_Rsym_value              0.085 
_reflns.pdbx_netI_over_sigmaI        18.9 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_redundancy              4.2 
_reflns.R_free_details               ? 
_reflns.limit_h_max                  ? 
_reflns.limit_h_min                  ? 
_reflns.limit_k_max                  ? 
_reflns.limit_k_min                  ? 
_reflns.limit_l_max                  ? 
_reflns.limit_l_min                  ? 
_reflns.observed_criterion_F_max     ? 
_reflns.observed_criterion_F_min     ? 
_reflns.pdbx_chi_squared             ? 
_reflns.pdbx_scaling_rejects         ? 
_reflns.pdbx_ordinal                 1 
_reflns.pdbx_diffrn_id               1 
# 
_reflns_shell.d_res_high             2.033 
_reflns_shell.d_res_low              2.07 
_reflns_shell.percent_possible_all   94.2 
_reflns_shell.Rmerge_I_obs           0.642 
_reflns_shell.pdbx_Rsym_value        0.450 
_reflns_shell.meanI_over_sigI_obs    2.4 
_reflns_shell.pdbx_redundancy        3.8 
_reflns_shell.percent_possible_obs   ? 
_reflns_shell.number_unique_all      2633 
_reflns_shell.number_measured_all    ? 
_reflns_shell.number_measured_obs    ? 
_reflns_shell.number_unique_obs      ? 
_reflns_shell.pdbx_chi_squared       ? 
_reflns_shell.pdbx_ordinal           1 
_reflns_shell.pdbx_diffrn_id         1 
# 
_refine.entry_id                                 4JO1 
_refine.ls_number_reflns_obs                     56014 
_refine.ls_number_reflns_all                     56059 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             36.226 
_refine.ls_d_res_high                            2.033 
_refine.ls_percent_reflns_obs                    99.51 
_refine.ls_R_factor_obs                          0.1834 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.1813 
_refine.ls_R_factor_R_free                       0.2232 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.06 
_refine.ls_number_reflns_R_free                  2834 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            -0.0938 
_refine.aniso_B[2][2]                            -0.5944 
_refine.aniso_B[3][3]                            0.6882 
_refine.aniso_B[1][2]                            -0.0000 
_refine.aniso_B[1][3]                            -0.0522 
_refine.aniso_B[2][3]                            -0.0000 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_ksol                 0.368 
_refine.solvent_model_param_bsol                 59.511 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.86 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      'PDB ENTRY 2X71' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            0.27 
_refine.pdbx_overall_phase_error                 21.32 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.B_iso_min                                ? 
_refine.B_iso_max                                ? 
_refine.overall_SU_R_free                        ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        6442 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.number_atoms_solvent             805 
_refine_hist.number_atoms_total               7252 
_refine_hist.d_res_high                       2.033 
_refine_hist.d_res_low                        36.226 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_restraint_function 
_refine_ls_restr.pdbx_refine_id 
f_bond_d           0.008  ? ? 6598 ? 'X-RAY DIFFRACTION' 
f_angle_d          1.168  ? ? 9004 ? 'X-RAY DIFFRACTION' 
f_dihedral_angle_d 13.243 ? ? 2276 ? 'X-RAY DIFFRACTION' 
f_chiral_restr     0.081  ? ? 1074 ? 'X-RAY DIFFRACTION' 
f_plane_restr      0.005  ? ? 1158 ? 'X-RAY DIFFRACTION' 
# 
loop_
_refine_ls_restr_ncs.dom_id 
_refine_ls_restr_ncs.pdbx_auth_asym_id 
_refine_ls_restr_ncs.pdbx_number 
_refine_ls_restr_ncs.rms_dev_position 
_refine_ls_restr_ncs.weight_position 
_refine_ls_restr_ncs.pdbx_type 
_refine_ls_restr_ncs.pdbx_ens_id 
_refine_ls_restr_ncs.pdbx_ordinal 
_refine_ls_restr_ncs.pdbx_refine_id 
_refine_ls_restr_ncs.ncs_model_details 
_refine_ls_restr_ncs.rms_dev_B_iso 
_refine_ls_restr_ncs.weight_B_iso 
_refine_ls_restr_ncs.pdbx_asym_id 
_refine_ls_restr_ncs.pdbx_rms 
_refine_ls_restr_ncs.pdbx_weight 
1 L 819 ?     ? POSITIONAL 1 1  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
2 M 819 0.055 ? POSITIONAL 1 2  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
1 L 764 ?     ? POSITIONAL 2 3  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
2 M 764 0.040 ? POSITIONAL 2 4  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
1 H 825 ?     ? POSITIONAL 3 5  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
2 I 825 0.040 ? POSITIONAL 3 6  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
1 H 581 ?     ? POSITIONAL 4 7  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
2 I 581 0.059 ? POSITIONAL 4 8  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
1 P 74  ?     ? POSITIONAL 5 9  'X-RAY DIFFRACTION' ? ? ? ? ? ? 
2 Q 74  0.025 ? POSITIONAL 5 10 'X-RAY DIFFRACTION' ? ? ? ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.R_factor_R_free 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.pdbx_refine_id 
. 2.0330 2.0681  2520 0.2226 95.0  0.2340 . . 139 . . . . 'X-RAY DIFFRACTION' 
. 2.0681 2.1057  2631 0.2376 99.0  0.3245 . . 152 . . . . 'X-RAY DIFFRACTION' 
. 2.1057 2.1462  2663 0.2239 100.0 0.2789 . . 122 . . . . 'X-RAY DIFFRACTION' 
. 2.1462 2.1900  2645 0.2126 100.0 0.2469 . . 142 . . . . 'X-RAY DIFFRACTION' 
. 2.1900 2.2376  2634 0.2054 100.0 0.2527 . . 133 . . . . 'X-RAY DIFFRACTION' 
. 2.2376 2.2896  2655 0.2045 100.0 0.2830 . . 162 . . . . 'X-RAY DIFFRACTION' 
. 2.2896 2.3469  2663 0.2004 100.0 0.2651 . . 143 . . . . 'X-RAY DIFFRACTION' 
. 2.3469 2.4103  2631 0.1940 100.0 0.2478 . . 149 . . . . 'X-RAY DIFFRACTION' 
. 2.4103 2.4812  2653 0.1921 100.0 0.2171 . . 122 . . . . 'X-RAY DIFFRACTION' 
. 2.4812 2.5613  2707 0.1904 100.0 0.2296 . . 133 . . . . 'X-RAY DIFFRACTION' 
. 2.5613 2.6528  2623 0.1944 100.0 0.2602 . . 154 . . . . 'X-RAY DIFFRACTION' 
. 2.6528 2.7590  2664 0.1859 100.0 0.2755 . . 144 . . . . 'X-RAY DIFFRACTION' 
. 2.7590 2.8845  2664 0.1903 100.0 0.2742 . . 142 . . . . 'X-RAY DIFFRACTION' 
. 2.8845 3.0365  2676 0.1849 100.0 0.2172 . . 146 . . . . 'X-RAY DIFFRACTION' 
. 3.0365 3.2266  2675 0.1791 100.0 0.2192 . . 151 . . . . 'X-RAY DIFFRACTION' 
. 3.2266 3.4756  2645 0.1760 100.0 0.2032 . . 141 . . . . 'X-RAY DIFFRACTION' 
. 3.4756 3.8250  2689 0.1656 100.0 0.2012 . . 152 . . . . 'X-RAY DIFFRACTION' 
. 3.8250 4.3777  2701 0.1589 100.0 0.1821 . . 127 . . . . 'X-RAY DIFFRACTION' 
. 4.3777 5.5123  2714 0.1395 100.0 0.1712 . . 138 . . . . 'X-RAY DIFFRACTION' 
. 5.5123 36.2321 2727 0.1975 99.0  0.2205 . . 142 . . . . 'X-RAY DIFFRACTION' 
# 
loop_
_struct_ncs_dom.id 
_struct_ncs_dom.details 
_struct_ncs_dom.pdbx_ens_id 
1 ? 1 
2 ? 1 
1 ? 2 
2 ? 2 
1 ? 3 
2 ? 3 
1 ? 4 
2 ? 4 
1 ? 5 
2 ? 5 
# 
loop_
_struct_ncs_dom_lim.dom_id 
_struct_ncs_dom_lim.beg_auth_asym_id 
_struct_ncs_dom_lim.beg_auth_seq_id 
_struct_ncs_dom_lim.end_auth_asym_id 
_struct_ncs_dom_lim.end_auth_seq_id 
_struct_ncs_dom_lim.pdbx_component_id 
_struct_ncs_dom_lim.pdbx_refine_code 
_struct_ncs_dom_lim.beg_label_asym_id 
_struct_ncs_dom_lim.beg_label_comp_id 
_struct_ncs_dom_lim.beg_label_seq_id 
_struct_ncs_dom_lim.beg_label_alt_id 
_struct_ncs_dom_lim.end_label_asym_id 
_struct_ncs_dom_lim.end_label_comp_id 
_struct_ncs_dom_lim.end_label_seq_id 
_struct_ncs_dom_lim.end_label_alt_id 
_struct_ncs_dom_lim.pdbx_ens_id 
_struct_ncs_dom_lim.selection_details 
_struct_ncs_dom_lim.beg_auth_comp_id 
_struct_ncs_dom_lim.end_auth_comp_id 
1 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 1 
;chain 'L' and (resseq 2:107 )
;
? ? 
2 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 1 
;chain 'M' and (resseq 2:107 )
;
? ? 
1 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 2 
;chain 'L' and (resseq 109:211 ) and (not resseq 159)
;
? ? 
2 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 2 
;chain 'M' and (resseq 109:211 ) and (not resseq 159)
;
? ? 
1 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 3 
;chain 'H' and (resseq 2:113 ) and (not resseq 53:54)
;
? ? 
2 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 3 
;chain 'I' and (resseq 2:113 ) and (not resseq 53:54)
;
? ? 
1 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 4 
;chain 'H' and (resseq 115:213 ) and (not (resseq 128:135 or resseq 171:174 or resseq 186:190 or resseq 211:213))
;
? ? 
2 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 4 
;chain 'I' and (resseq 115:213 ) and (not (resseq 128:135 or resseq 171:174 or resseq 186:190 or resseq 211:213))
;
? ? 
1 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 5 
;chain 'P'
;
? ? 
2 ? ? ? ? 1 ? ? ? ? ? ? ? ? ? 5 
;Chain 'Q'
;
? ? 
# 
loop_
_struct_ncs_ens.id 
_struct_ncs_ens.details 
1 ? 
2 ? 
3 ? 
4 ? 
5 ? 
# 
_struct.entry_id                  4JO1 
_struct.title                     'Crystal structure of rabbit mAb R56 Fab in complex with V3 crown of HIV-1 JR-FL gp120' 
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        4JO1 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM/VIRAL PROTEIN' 
_struct_keywords.text            'Ig, antibody, IMMUNE SYSTEM-VIRAL PROTEIN complex' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 1 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 5 ? 
M N N 5 ? 
N N N 5 ? 
O N N 5 ? 
P N N 5 ? 
Q N N 5 ? 
# 
_struct_biol.id        1 
_struct_biol.details   ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  1  VAL A 28  B ASN A 32  ? VAL L 27  ASN L 31  5 ? 5 
HELX_P HELX_P2  2  GLN A 80  ? ALA A 84  ? GLN L 79  ALA L 83  5 ? 5 
HELX_P HELX_P3  3  ALA A 126 ? ALA A 131 ? ALA L 121 ALA L 126 1 ? 6 
HELX_P HELX_P4  4  SER A 187 ? SER A 192 ? SER L 182 SER L 187 1 ? 6 
HELX_P HELX_P5  5  GLY A 214 ? CYS A 216 ? GLY L 209 CYS L 211 5 ? 3 
HELX_P HELX_P6  6  THR B 87  ? THR B 91  ? THR H 83  THR H 87  5 ? 5 
HELX_P HELX_P7  7  SER B 156 ? THR B 158 ? SER H 156 THR H 158 5 ? 3 
HELX_P HELX_P8  8  PRO B 198 ? ASN B 201 ? PRO H 198 ASN H 201 5 ? 4 
HELX_P HELX_P9  9  VAL D 28  B ASN D 32  ? VAL M 27  ASN M 31  5 ? 5 
HELX_P HELX_P10 10 GLN D 80  ? ALA D 84  ? GLN M 79  ALA M 83  5 ? 5 
HELX_P HELX_P11 11 ALA D 126 ? ALA D 131 ? ALA M 121 ALA M 126 1 ? 6 
HELX_P HELX_P12 12 SER D 187 ? SER D 192 ? SER M 182 SER M 187 1 ? 6 
HELX_P HELX_P13 13 GLY D 214 ? CYS D 216 ? GLY M 209 CYS M 211 5 ? 3 
HELX_P HELX_P14 14 THR E 87  ? THR E 91  ? THR I 83  THR I 87  5 ? 5 
HELX_P HELX_P15 15 SER E 156 ? THR E 158 ? SER I 156 THR I 158 5 ? 3 
HELX_P HELX_P16 16 PRO E 198 ? ASN E 201 ? PRO I 198 ASN I 201 5 ? 4 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 22  SG ? ? ? 1_555 A CYS 89  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.020 ? ? 
disulf2  disulf ? ? A CYS 81  SG ? ? ? 1_555 A CYS 175 SG ? ? L CYS 80  L CYS 170 1_555 ? ? ? ? ? ? ? 2.049 ? ? 
disulf3  disulf ? ? A CYS 95  SG ? ? ? 1_555 A CYS 100 SG ? D L CYS 94  L CYS 95  1_555 ? ? ? ? ? ? ? 2.058 ? ? 
disulf4  disulf ? ? A CYS 139 SG ? ? ? 1_555 A CYS 198 SG ? ? L CYS 134 L CYS 193 1_555 ? ? ? ? ? ? ? 2.034 ? ? 
disulf5  disulf ? ? A CYS 216 SG ? ? ? 1_555 B CYS 127 SG ? ? L CYS 211 H CYS 127 1_555 ? ? ? ? ? ? ? 2.068 ? ? 
disulf6  disulf ? ? B CYS 21  SG ? ? ? 1_555 B CYS 96  SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.050 ? ? 
disulf7  disulf ? ? B CYS 35  SG ? A ? 1_555 B CYS 50  SG ? ? H CYS 35  H CYS 50  1_555 ? ? ? ? ? ? ? 2.027 ? ? 
disulf8  disulf ? ? B CYS 128 SG ? ? ? 1_555 B CYS 213 SG ? ? H CYS 128 H CYS 213 1_555 ? ? ? ? ? ? ? 2.037 ? ? 
disulf9  disulf ? ? B CYS 140 SG ? ? ? 1_555 B CYS 193 SG ? ? H CYS 140 H CYS 193 1_555 ? ? ? ? ? ? ? 2.021 ? ? 
disulf10 disulf ? ? D CYS 22  SG ? ? ? 1_555 D CYS 89  SG ? ? M CYS 23  M CYS 88  1_555 ? ? ? ? ? ? ? 2.018 ? ? 
disulf11 disulf ? ? D CYS 81  SG ? ? ? 1_555 D CYS 175 SG ? ? M CYS 80  M CYS 170 1_555 ? ? ? ? ? ? ? 2.051 ? ? 
disulf12 disulf ? ? D CYS 95  SG ? ? ? 1_555 D CYS 100 SG ? D M CYS 94  M CYS 95  1_555 ? ? ? ? ? ? ? 2.044 ? ? 
disulf13 disulf ? ? D CYS 139 SG ? ? ? 1_555 D CYS 198 SG ? ? M CYS 134 M CYS 193 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf14 disulf ? ? D CYS 216 SG ? ? ? 1_555 E CYS 127 SG ? ? M CYS 211 I CYS 127 1_555 ? ? ? ? ? ? ? 2.002 ? ? 
disulf15 disulf ? ? E CYS 21  SG ? ? ? 1_555 E CYS 96  SG ? ? I CYS 22  I CYS 92  1_555 ? ? ? ? ? ? ? 2.044 ? ? 
disulf16 disulf ? ? E CYS 35  SG ? A ? 1_555 E CYS 50  SG ? ? I CYS 35  I CYS 50  1_555 ? ? ? ? ? ? ? 2.039 ? ? 
disulf17 disulf ? ? E CYS 128 SG ? ? ? 1_555 E CYS 213 SG ? ? I CYS 128 I CYS 213 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
disulf18 disulf ? ? E CYS 140 SG ? ? ? 1_555 E CYS 193 SG ? ? I CYS 140 I CYS 193 1_555 ? ? ? ? ? ? ? 2.036 ? ? 
metalc1  metalc ? ? G CA  .   CA ? ? ? 1_555 L HOH .   O  ? ? L CA  301 L HOH 426 1_555 ? ? ? ? ? ? ? 3.198 ? ? 
metalc2  metalc ? ? I CA  .   CA ? ? ? 1_555 M HOH .   O  ? ? H CA  301 H HOH 562 1_555 ? ? ? ? ? ? ? 3.106 ? ? 
metalc3  metalc ? ? J CA  .   CA ? ? ? 1_555 P HOH .   O  ? ? M CA  301 I HOH 408 1_555 ? ? ? ? ? ? ? 3.155 ? ? 
metalc4  metalc ? ? K CA  .   CA ? ? ? 1_555 P HOH .   O  ? ? I CA  301 I HOH 434 1_555 ? ? ? ? ? ? ? 3.157 ? ? 
metalc5  metalc ? ? K CA  .   CA ? ? ? 1_555 P HOH .   O  ? ? I CA  301 I HOH 436 1_555 ? ? ? ? ? ? ? 3.125 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1  THR 6   A . ? THR 7   L PRO 7   A ? PRO 8   L 1 -1.74  
2  PHE 145 A . ? PHE 140 L PRO 146 A ? PRO 141 L 1 -0.12  
3  PRO 132 B . ? PRO 132 H SER 133 B ? SER 133 H 1 8.83   
4  LEU 146 B . ? LEU 146 H PRO 147 B ? PRO 147 H 1 -9.50  
5  GLU 148 B . ? GLU 148 H PRO 149 B ? PRO 149 H 1 -1.70  
6  THR 6   D . ? THR 7   M PRO 7   D ? PRO 8   M 1 -2.66  
7  PHE 145 D . ? PHE 140 M PRO 146 D ? PRO 141 M 1 1.03   
8  LEU 146 E . ? LEU 146 I PRO 147 E ? PRO 147 I 1 -7.74  
9  GLU 148 E . ? GLU 148 I PRO 149 E ? PRO 149 I 1 0.54   
10 SER 211 E . ? SER 211 I THR 212 E ? THR 212 I 1 -13.46 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
A ? 4 ? 
B ? 6 ? 
C ? 4 ? 
D ? 4 ? 
E ? 4 ? 
F ? 4 ? 
G ? 6 ? 
H ? 4 ? 
I ? 4 ? 
J ? 4 ? 
K ? 3 ? 
L ? 4 ? 
M ? 6 ? 
N ? 4 ? 
O ? 4 ? 
P ? 4 ? 
Q ? 4 ? 
R ? 6 ? 
S ? 4 ? 
T ? 4 ? 
U ? 4 ? 
V ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
A 1 2 ? anti-parallel 
A 2 3 ? anti-parallel 
A 3 4 ? anti-parallel 
B 1 2 ? parallel      
B 2 3 ? anti-parallel 
B 3 4 ? anti-parallel 
B 4 5 ? anti-parallel 
B 5 6 ? anti-parallel 
C 1 2 ? parallel      
C 2 3 ? anti-parallel 
C 3 4 ? anti-parallel 
D 1 2 ? anti-parallel 
D 2 3 ? anti-parallel 
D 3 4 ? anti-parallel 
E 1 2 ? anti-parallel 
E 2 3 ? anti-parallel 
E 3 4 ? anti-parallel 
F 1 2 ? anti-parallel 
F 2 3 ? anti-parallel 
F 3 4 ? anti-parallel 
G 1 2 ? parallel      
G 2 3 ? anti-parallel 
G 3 4 ? anti-parallel 
G 4 5 ? anti-parallel 
G 5 6 ? anti-parallel 
H 1 2 ? parallel      
H 2 3 ? anti-parallel 
H 3 4 ? anti-parallel 
I 1 2 ? anti-parallel 
I 2 3 ? anti-parallel 
I 3 4 ? anti-parallel 
J 1 2 ? anti-parallel 
J 2 3 ? anti-parallel 
J 3 4 ? anti-parallel 
K 1 2 ? anti-parallel 
K 2 3 ? anti-parallel 
L 1 2 ? anti-parallel 
L 2 3 ? anti-parallel 
L 3 4 ? anti-parallel 
M 1 2 ? parallel      
M 2 3 ? anti-parallel 
M 3 4 ? anti-parallel 
M 4 5 ? anti-parallel 
M 5 6 ? anti-parallel 
N 1 2 ? parallel      
N 2 3 ? anti-parallel 
N 3 4 ? anti-parallel 
O 1 2 ? anti-parallel 
O 2 3 ? anti-parallel 
O 3 4 ? anti-parallel 
P 1 2 ? anti-parallel 
P 2 3 ? anti-parallel 
P 3 4 ? anti-parallel 
Q 1 2 ? anti-parallel 
Q 2 3 ? anti-parallel 
Q 3 4 ? anti-parallel 
R 1 2 ? parallel      
R 2 3 ? anti-parallel 
R 3 4 ? anti-parallel 
R 4 5 ? anti-parallel 
R 5 6 ? anti-parallel 
S 1 2 ? parallel      
S 2 3 ? anti-parallel 
S 3 4 ? anti-parallel 
T 1 2 ? anti-parallel 
T 2 3 ? anti-parallel 
T 3 4 ? anti-parallel 
U 1 2 ? anti-parallel 
U 2 3 ? anti-parallel 
U 3 4 ? anti-parallel 
V 1 2 ? anti-parallel 
V 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
A 1 LEU A 3   ? THR A 6   ? LEU L 4   THR L 7   
A 2 VAL A 18  ? SER A 24  ? VAL L 19  SER L 25  
A 3 GLN A 71  ? ILE A 76  ? GLN L 70  ILE L 75  
A 4 PHE A 63  ? SER A 68  ? PHE L 62  SER L 67  
B 1 SER A 9   ? ALA A 13  ? SER L 10  ALA L 14  
B 2 THR A 107 ? ARG A 112 ? THR L 102 ARG L 107 
B 3 ALA A 85  ? GLY A 92  ? ALA L 84  GLY L 91  
B 4 LEU A 34  ? GLN A 39  ? LEU L 33  GLN L 38  
B 5 ARG A 46  ? TYR A 50  ? ARG L 45  TYR L 49  
B 6 LYS A 54  ? LEU A 55  ? LYS L 53  LEU L 54  
C 1 SER A 9   ? ALA A 13  ? SER L 10  ALA L 14  
C 2 THR A 107 ? ARG A 112 ? THR L 102 ARG L 107 
C 3 ALA A 85  ? GLY A 92  ? ALA L 84  GLY L 91  
C 4 ALA A 101 ? PHE A 103 ? ALA L 96  PHE L 98  
D 1 THR A 119 ? PHE A 123 ? THR L 114 PHE L 118 
D 2 THR A 134 ? TYR A 144 ? THR L 129 TYR L 139 
D 3 TYR A 177 ? THR A 186 ? TYR L 172 THR L 181 
D 4 ILE A 163 ? LYS A 167 ? ILE L 158 LYS L 162 
E 1 THR A 157 ? THR A 158 ? THR L 152 THR L 153 
E 2 THR A 149 ? VAL A 154 ? THR L 144 VAL L 149 
E 3 GLU A 195 ? GLN A 202 ? GLU L 190 GLN L 197 
E 4 THR A 205 ? ASN A 212 ? THR L 200 ASN L 207 
F 1 SER B 2   ? SER B 6   ? SER H 3   SER H 7   
F 2 LEU B 17  ? SER B 24  ? LEU H 18  SER H 25  
F 3 THR B 78  ? MET B 83  ? THR H 76  MET H 81  
F 4 PHE B 69  ? SER B 75  ? PHE H 67  SER H 73  
G 1 LEU B 10  ? VAL B 11  ? LEU H 11  VAL H 12  
G 2 THR B 107 ? VAL B 111 ? THR H 107 VAL H 111 
G 3 ALA B 92  ? ARG B 98  ? ALA H 88  ARG H 94  
G 4 ASP B 33  ? GLN B 39  ? ASP H 34  GLN H 39  
G 5 LEU B 45  ? GLU B 52  ? LEU H 45  GLU H 52  
G 6 ALA B 59  ? TYR B 61  ? ALA H 57  TYR H 59  
H 1 LEU B 10  ? VAL B 11  ? LEU H 11  VAL H 12  
H 2 THR B 107 ? VAL B 111 ? THR H 107 VAL H 111 
H 3 ALA B 92  ? ARG B 98  ? ALA H 88  ARG H 94  
H 4 LEU B 102 ? TRP B 103 ? LEU H 102 TRP H 103 
I 1 SER B 120 ? LEU B 124 ? SER H 120 LEU H 124 
I 2 THR B 135 ? TYR B 145 ? THR H 135 TYR H 145 
I 3 TYR B 176 ? THR B 185 ? TYR H 176 THR H 185 
I 4 VAL B 163 ? THR B 165 ? VAL H 163 THR H 165 
J 1 SER B 120 ? LEU B 124 ? SER H 120 LEU H 124 
J 2 THR B 135 ? TYR B 145 ? THR H 135 TYR H 145 
J 3 TYR B 176 ? THR B 185 ? TYR H 176 THR H 185 
J 4 VAL B 169 ? ARG B 170 ? VAL H 169 ARG H 170 
K 1 THR B 151 ? TRP B 154 ? THR H 151 TRP H 154 
K 2 VAL B 191 ? HIS B 197 ? VAL H 191 HIS H 197 
K 3 THR B 202 ? VAL B 208 ? THR H 202 VAL H 208 
L 1 LEU D 3   ? THR D 6   ? LEU M 4   THR M 7   
L 2 VAL D 18  ? SER D 24  ? VAL M 19  SER M 25  
L 3 GLN D 71  ? ILE D 76  ? GLN M 70  ILE M 75  
L 4 PHE D 63  ? SER D 68  ? PHE M 62  SER M 67  
M 1 SER D 9   ? ALA D 13  ? SER M 10  ALA M 14  
M 2 THR D 107 ? ARG D 112 ? THR M 102 ARG M 107 
M 3 ALA D 85  ? GLY D 92  ? ALA M 84  GLY M 91  
M 4 LEU D 34  ? GLN D 39  ? LEU M 33  GLN M 38  
M 5 ARG D 46  ? TYR D 50  ? ARG M 45  TYR M 49  
M 6 LYS D 54  ? LEU D 55  ? LYS M 53  LEU M 54  
N 1 SER D 9   ? ALA D 13  ? SER M 10  ALA M 14  
N 2 THR D 107 ? ARG D 112 ? THR M 102 ARG M 107 
N 3 ALA D 85  ? GLY D 92  ? ALA M 84  GLY M 91  
N 4 ALA D 101 ? PHE D 103 ? ALA M 96  PHE M 98  
O 1 THR D 119 ? PHE D 123 ? THR M 114 PHE M 118 
O 2 THR D 134 ? TYR D 144 ? THR M 129 TYR M 139 
O 3 TYR D 177 ? THR D 186 ? TYR M 172 THR M 181 
O 4 ILE D 163 ? LYS D 167 ? ILE M 158 LYS M 162 
P 1 THR D 157 ? THR D 158 ? THR M 152 THR M 153 
P 2 THR D 149 ? VAL D 154 ? THR M 144 VAL M 149 
P 3 GLU D 195 ? GLN D 202 ? GLU M 190 GLN M 197 
P 4 THR D 205 ? ASN D 212 ? THR M 200 ASN M 207 
Q 1 SER E 2   ? SER E 6   ? SER I 3   SER I 7   
Q 2 LEU E 17  ? SER E 24  ? LEU I 18  SER I 25  
Q 3 THR E 78  ? MET E 83  ? THR I 76  MET I 81  
Q 4 PHE E 69  ? SER E 75  ? PHE I 67  SER I 73  
R 1 LEU E 10  ? VAL E 11  ? LEU I 11  VAL I 12  
R 2 THR E 107 ? VAL E 111 ? THR I 107 VAL I 111 
R 3 ALA E 92  ? ARG E 98  ? ALA I 88  ARG I 94  
R 4 ASP E 33  ? GLN E 39  ? ASP I 34  GLN I 39  
R 5 LEU E 45  ? GLU E 52  ? LEU I 45  GLU I 52  
R 6 ALA E 59  ? TYR E 61  ? ALA I 57  TYR I 59  
S 1 LEU E 10  ? VAL E 11  ? LEU I 11  VAL I 12  
S 2 THR E 107 ? VAL E 111 ? THR I 107 VAL I 111 
S 3 ALA E 92  ? ARG E 98  ? ALA I 88  ARG I 94  
S 4 LEU E 102 ? TRP E 103 ? LEU I 102 TRP I 103 
T 1 SER E 120 ? LEU E 124 ? SER I 120 LEU I 124 
T 2 VAL E 136 ? TYR E 145 ? VAL I 136 TYR I 145 
T 3 TYR E 176 ? VAL E 184 ? TYR I 176 VAL I 184 
T 4 VAL E 163 ? THR E 165 ? VAL I 163 THR I 165 
U 1 SER E 120 ? LEU E 124 ? SER I 120 LEU I 124 
U 2 VAL E 136 ? TYR E 145 ? VAL I 136 TYR I 145 
U 3 TYR E 176 ? VAL E 184 ? TYR I 176 VAL I 184 
U 4 VAL E 169 ? ARG E 170 ? VAL I 169 ARG I 170 
V 1 THR E 151 ? TRP E 154 ? THR I 151 TRP I 154 
V 2 VAL E 191 ? HIS E 197 ? VAL I 191 HIS I 197 
V 3 THR E 202 ? VAL E 208 ? THR I 202 VAL I 208 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
A 1 2 N THR A 6   ? N THR L 7   O ASN A 21  ? O ASN L 22  
A 2 3 N ILE A 20  ? N ILE L 21  O PHE A 74  ? O PHE L 73  
A 3 4 O THR A 75  ? O THR L 74  N LYS A 64  ? N LYS L 63  
B 1 2 N THR A 12  ? N THR L 13  O ARG A 112 ? O ARG L 107 
B 2 3 O VAL A 109 ? O VAL L 104 N ALA A 85  ? N ALA L 84  
B 3 4 O TYR A 88  ? O TYR L 87  N PHE A 37  ? N PHE L 36  
B 4 5 N TRP A 36  ? N TRP L 35  O LEU A 48  ? O LEU L 47  
B 5 6 N TYR A 50  ? N TYR L 49  O LYS A 54  ? O LYS L 53  
C 1 2 N THR A 12  ? N THR L 13  O ARG A 112 ? O ARG L 107 
C 2 3 O VAL A 109 ? O VAL L 104 N ALA A 85  ? N ALA L 84  
C 3 4 N GLY A 91  ? N GLY L 90  O ALA A 102 ? O ALA L 97  
D 1 2 N PHE A 123 ? N PHE L 118 O VAL A 138 ? O VAL L 133 
D 2 3 N CYS A 139 ? N CYS L 134 O SER A 181 ? O SER L 176 
D 3 4 O SER A 180 ? O SER L 175 N SER A 166 ? N SER L 161 
E 1 2 O THR A 157 ? O THR L 152 N VAL A 154 ? N VAL L 149 
E 2 3 N THR A 151 ? N THR L 146 O LYS A 199 ? O LYS L 194 
E 3 4 N CYS A 198 ? N CYS L 193 O GLN A 209 ? O GLN L 204 
F 1 2 N GLU B 4   ? N GLU H 5   O LYS B 22  ? O LYS H 23  
F 2 3 N CYS B 21  ? N CYS H 22  O VAL B 79  ? O VAL H 77  
F 3 4 O GLN B 82  ? O GLN H 80  N THR B 70  ? N THR H 68  
G 1 2 N VAL B 11  ? N VAL H 12  O ILE B 110 ? O ILE H 110 
G 2 3 O VAL B 109 ? O VAL H 109 N ALA B 92  ? N ALA H 88  
G 3 4 O PHE B 95  ? O PHE H 91  N VAL B 37  ? N VAL H 37  
G 4 5 N ARG B 38  ? N ARG H 38  O GLU B 46  ? O GLU H 46  
G 5 6 N CYS B 50  ? N CYS H 50  O ALA B 60  ? O ALA H 58  
H 1 2 N VAL B 11  ? N VAL H 12  O ILE B 110 ? O ILE H 110 
H 2 3 O VAL B 109 ? O VAL H 109 N ALA B 92  ? N ALA H 88  
H 3 4 N ARG B 98  ? N ARG H 94  O LEU B 102 ? O LEU H 102 
I 1 2 N SER B 120 ? N SER H 120 O LYS B 143 ? O LYS H 143 
I 2 3 N VAL B 142 ? N VAL H 142 O LEU B 178 ? O LEU H 178 
I 3 4 O VAL B 181 ? O VAL H 181 N ARG B 164 ? N ARG H 164 
J 1 2 N SER B 120 ? N SER H 120 O LYS B 143 ? O LYS H 143 
J 2 3 N VAL B 142 ? N VAL H 142 O LEU B 178 ? O LEU H 178 
J 3 4 O SER B 177 ? O SER H 177 N VAL B 169 ? N VAL H 169 
K 1 2 N THR B 153 ? N THR H 153 O ASN B 194 ? O ASN H 194 
K 2 3 N VAL B 191 ? N VAL H 191 O VAL B 208 ? O VAL H 208 
L 1 2 N THR D 4   ? N THR M 5   O GLN D 23  ? O GLN M 24  
L 2 3 N ILE D 20  ? N ILE M 21  O PHE D 74  ? O PHE M 73  
L 3 4 O THR D 75  ? O THR M 74  N LYS D 64  ? N LYS M 63  
M 1 2 N THR D 12  ? N THR M 13  O ARG D 112 ? O ARG M 107 
M 2 3 O VAL D 109 ? O VAL M 104 N ALA D 85  ? N ALA M 84  
M 3 4 O THR D 86  ? O THR M 85  N GLN D 39  ? N GLN M 38  
M 4 5 N TRP D 36  ? N TRP M 35  O LEU D 48  ? O LEU M 47  
M 5 6 N TYR D 50  ? N TYR M 49  O LYS D 54  ? O LYS M 53  
N 1 2 N THR D 12  ? N THR M 13  O ARG D 112 ? O ARG M 107 
N 2 3 O VAL D 109 ? O VAL M 104 N ALA D 85  ? N ALA M 84  
N 3 4 N GLY D 91  ? N GLY M 90  O ALA D 102 ? O ALA M 97  
O 1 2 N PHE D 123 ? N PHE M 118 O VAL D 138 ? O VAL M 133 
O 2 3 N CYS D 139 ? N CYS M 134 O SER D 181 ? O SER M 176 
O 3 4 O SER D 180 ? O SER M 175 N SER D 166 ? N SER M 161 
P 1 2 O THR D 157 ? O THR M 152 N VAL D 154 ? N VAL M 149 
P 2 3 N THR D 149 ? N THR M 144 O THR D 201 ? O THR M 196 
P 3 4 N CYS D 198 ? N CYS M 193 O GLN D 209 ? O GLN M 204 
Q 1 2 N GLU E 4   ? N GLU I 5   O LYS E 22  ? O LYS I 23  
Q 2 3 N CYS E 21  ? N CYS I 22  O VAL E 79  ? O VAL I 77  
Q 3 4 O THR E 80  ? O THR I 78  N SER E 72  ? N SER I 70  
R 1 2 N VAL E 11  ? N VAL I 12  O ILE E 110 ? O ILE I 110 
R 2 3 O VAL E 109 ? O VAL I 109 N ALA E 92  ? N ALA I 88  
R 3 4 O PHE E 95  ? O PHE I 91  N VAL E 37  ? N VAL I 37  
R 4 5 N ARG E 38  ? N ARG I 38  O GLU E 46  ? O GLU I 46  
R 5 6 N CYS E 50  ? N CYS I 50  O ALA E 60  ? O ALA I 58  
S 1 2 N VAL E 11  ? N VAL I 12  O ILE E 110 ? O ILE I 110 
S 2 3 O VAL E 109 ? O VAL I 109 N ALA E 92  ? N ALA I 88  
S 3 4 N ARG E 98  ? N ARG I 94  O LEU E 102 ? O LEU I 102 
T 1 2 N SER E 120 ? N SER I 120 O LYS E 143 ? O LYS I 143 
T 2 3 N VAL E 142 ? N VAL I 142 O LEU E 178 ? O LEU I 178 
T 3 4 O VAL E 181 ? O VAL I 181 N ARG E 164 ? N ARG I 164 
U 1 2 N SER E 120 ? N SER I 120 O LYS E 143 ? O LYS I 143 
U 2 3 N VAL E 142 ? N VAL I 142 O LEU E 178 ? O LEU I 178 
U 3 4 O SER E 177 ? O SER I 177 N VAL E 169 ? N VAL I 169 
V 1 2 N THR E 153 ? N THR I 153 O ASN E 194 ? O ASN I 194 
V 2 3 N VAL E 191 ? N VAL I 191 O VAL E 208 ? O VAL I 208 
# 
loop_
_struct_site.id 
_struct_site.pdbx_evidence_code 
_struct_site.pdbx_auth_asym_id 
_struct_site.pdbx_auth_comp_id 
_struct_site.pdbx_auth_seq_id 
_struct_site.pdbx_auth_ins_code 
_struct_site.pdbx_num_residues 
_struct_site.details 
AC1 Software L CA 301 ? 2 'BINDING SITE FOR RESIDUE CA L 301' 
AC2 Software L CA 302 ? 2 'BINDING SITE FOR RESIDUE CA L 302' 
AC3 Software H CA 301 ? 1 'BINDING SITE FOR RESIDUE CA H 301' 
AC4 Software M CA 301 ? 2 'BINDING SITE FOR RESIDUE CA M 301' 
AC5 Software I CA 301 ? 1 'BINDING SITE FOR RESIDUE CA I 301' 
# 
loop_
_struct_site_gen.id 
_struct_site_gen.site_id 
_struct_site_gen.pdbx_num_res 
_struct_site_gen.label_comp_id 
_struct_site_gen.label_asym_id 
_struct_site_gen.label_seq_id 
_struct_site_gen.pdbx_auth_ins_code 
_struct_site_gen.auth_comp_id 
_struct_site_gen.auth_asym_id 
_struct_site_gen.auth_seq_id 
_struct_site_gen.label_atom_id 
_struct_site_gen.label_alt_id 
_struct_site_gen.symmetry 
_struct_site_gen.details 
1 AC1 2 TRP B 47  ? TRP H 47 . ? 1_555 ? 
2 AC1 2 PHE A 103 ? PHE L 98 . ? 1_555 ? 
3 AC2 2 PRO A 7   ? PRO L 8  . ? 1_555 ? 
4 AC2 2 SER A 8   ? SER L 9  . ? 1_555 ? 
5 AC3 1 TYR B 61  ? TYR H 59 . ? 1_555 ? 
6 AC4 2 TRP E 47  ? TRP I 47 . ? 1_555 ? 
7 AC4 2 PHE D 103 ? PHE M 98 . ? 1_555 ? 
8 AC5 1 TYR E 61  ? TYR I 59 . ? 1_555 ? 
# 
_database_PDB_matrix.entry_id          4JO1 
_database_PDB_matrix.origx[1][1]       1.000000 
_database_PDB_matrix.origx[1][2]       0.000000 
_database_PDB_matrix.origx[1][3]       0.000000 
_database_PDB_matrix.origx[2][1]       0.000000 
_database_PDB_matrix.origx[2][2]       1.000000 
_database_PDB_matrix.origx[2][3]       0.000000 
_database_PDB_matrix.origx[3][1]       0.000000 
_database_PDB_matrix.origx[3][2]       0.000000 
_database_PDB_matrix.origx[3][3]       1.000000 
_database_PDB_matrix.origx_vector[1]   0.00000 
_database_PDB_matrix.origx_vector[2]   0.00000 
_database_PDB_matrix.origx_vector[3]   0.00000 
# 
_atom_sites.entry_id                    4JO1 
_atom_sites.fract_transf_matrix[1][1]   0.014182 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000003 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013450 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011843 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CA 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLN A 1 1   ? -24.277 10.223  5.974   1.00 23.42  ? 2   GLN L N   1 
ATOM   2    C  CA  . GLN A 1 1   ? -24.372 9.196   6.988   1.00 23.83  ? 2   GLN L CA  1 
ATOM   3    C  C   . GLN A 1 1   ? -23.074 9.275   7.755   1.00 24.52  ? 2   GLN L C   1 
ATOM   4    O  O   . GLN A 1 1   ? -21.997 9.284   7.163   1.00 19.74  ? 2   GLN L O   1 
ATOM   5    C  CB  . GLN A 1 1   ? -24.566 7.809   6.359   1.00 19.48  ? 2   GLN L CB  1 
ATOM   6    C  CG  . GLN A 1 1   ? -24.505 7.783   4.827   1.00 25.32  ? 2   GLN L CG  1 
ATOM   7    C  CD  . GLN A 1 1   ? -25.473 8.731   4.136   1.00 37.75  ? 2   GLN L CD  1 
ATOM   8    O  OE1 . GLN A 1 1   ? -26.686 8.499   4.140   1.00 56.58  ? 2   GLN L OE1 1 
ATOM   9    N  NE2 . GLN A 1 1   ? -24.939 9.820   3.539   1.00 19.68  ? 2   GLN L NE2 1 
ATOM   10   N  N   . VAL A 1 2   ? -23.181 9.392   9.074   1.00 23.14  ? 3   VAL L N   1 
ATOM   11   C  CA  . VAL A 1 2   ? -22.004 9.533   9.920   1.00 24.12  ? 3   VAL L CA  1 
ATOM   12   C  C   . VAL A 1 2   ? -22.075 8.466   11.000  1.00 23.22  ? 3   VAL L C   1 
ATOM   13   O  O   . VAL A 1 2   ? -23.110 8.315   11.670  1.00 20.85  ? 3   VAL L O   1 
ATOM   14   C  CB  . VAL A 1 2   ? -21.943 10.931  10.567  1.00 26.44  ? 3   VAL L CB  1 
ATOM   15   C  CG1 . VAL A 1 2   ? -20.781 11.027  11.545  1.00 21.33  ? 3   VAL L CG1 1 
ATOM   16   C  CG2 . VAL A 1 2   ? -21.848 12.016  9.491   1.00 26.82  ? 3   VAL L CG2 1 
ATOM   17   N  N   . LEU A 1 3   ? -20.988 7.717   11.156  1.00 23.29  ? 4   LEU L N   1 
ATOM   18   C  CA  . LEU A 1 3   ? -20.936 6.600   12.105  1.00 16.51  ? 4   LEU L CA  1 
ATOM   19   C  C   . LEU A 1 3   ? -19.922 6.956   13.185  1.00 24.41  ? 4   LEU L C   1 
ATOM   20   O  O   . LEU A 1 3   ? -18.722 6.985   12.910  1.00 20.42  ? 4   LEU L O   1 
ATOM   21   C  CB  . LEU A 1 3   ? -20.460 5.334   11.377  1.00 18.73  ? 4   LEU L CB  1 
ATOM   22   C  CG  . LEU A 1 3   ? -21.275 4.045   11.371  1.00 27.80  ? 4   LEU L CG  1 
ATOM   23   C  CD1 . LEU A 1 3   ? -20.395 2.821   11.042  1.00 21.66  ? 4   LEU L CD1 1 
ATOM   24   C  CD2 . LEU A 1 3   ? -22.071 3.833   12.649  1.00 21.18  ? 4   LEU L CD2 1 
ATOM   25   N  N   . THR A 1 4   ? -20.396 7.235   14.402  1.00 22.04  ? 5   THR L N   1 
ATOM   26   C  CA  . THR A 1 4   ? -19.530 7.764   15.461  1.00 18.43  ? 5   THR L CA  1 
ATOM   27   C  C   . THR A 1 4   ? -19.051 6.637   16.371  1.00 19.78  ? 5   THR L C   1 
ATOM   28   O  O   . THR A 1 4   ? -19.871 5.999   17.028  1.00 17.99  ? 5   THR L O   1 
ATOM   29   C  CB  . THR A 1 4   ? -20.268 8.827   16.297  1.00 22.54  ? 5   THR L CB  1 
ATOM   30   O  OG1 . THR A 1 4   ? -20.675 9.913   15.443  1.00 19.91  ? 5   THR L OG1 1 
ATOM   31   C  CG2 . THR A 1 4   ? -19.361 9.366   17.411  1.00 23.49  ? 5   THR L CG2 1 
ATOM   32   N  N   . GLN A 1 5   ? -17.737 6.386   16.390  1.00 17.56  ? 6   GLN L N   1 
ATOM   33   C  CA  . GLN A 1 5   ? -17.176 5.248   17.117  1.00 20.97  ? 6   GLN L CA  1 
ATOM   34   C  C   . GLN A 1 5   ? -16.471 5.694   18.407  1.00 24.19  ? 6   GLN L C   1 
ATOM   35   O  O   . GLN A 1 5   ? -15.646 6.622   18.387  1.00 22.79  ? 6   GLN L O   1 
ATOM   36   C  CB  . GLN A 1 5   ? -16.188 4.461   16.234  1.00 18.53  ? 6   GLN L CB  1 
ATOM   37   C  CG  . GLN A 1 5   ? -15.616 3.216   16.925  1.00 19.85  ? 6   GLN L CG  1 
ATOM   38   C  CD  . GLN A 1 5   ? -14.803 2.321   16.002  1.00 22.30  ? 6   GLN L CD  1 
ATOM   39   O  OE1 . GLN A 1 5   ? -14.908 2.404   14.771  1.00 18.73  ? 6   GLN L OE1 1 
ATOM   40   N  NE2 . GLN A 1 5   ? -13.982 1.446   16.601  1.00 17.63  ? 6   GLN L NE2 1 
ATOM   41   N  N   . THR A 1 6   ? -16.794 5.031   19.518  1.00 18.97  ? 7   THR L N   1 
ATOM   42   C  CA  . THR A 1 6   ? -16.251 5.390   20.821  1.00 19.67  ? 7   THR L CA  1 
ATOM   43   C  C   . THR A 1 6   ? -15.942 4.119   21.613  1.00 24.41  ? 7   THR L C   1 
ATOM   44   O  O   . THR A 1 6   ? -16.648 3.113   21.469  1.00 22.19  ? 7   THR L O   1 
ATOM   45   C  CB  . THR A 1 6   ? -17.253 6.221   21.659  1.00 22.42  ? 7   THR L CB  1 
ATOM   46   O  OG1 . THR A 1 6   ? -18.445 5.455   21.870  1.00 28.07  ? 7   THR L OG1 1 
ATOM   47   C  CG2 . THR A 1 6   ? -17.623 7.534   20.969  1.00 23.62  ? 7   THR L CG2 1 
ATOM   48   N  N   . PRO A 1 7   ? -14.886 4.149   22.447  1.00 21.11  ? 8   PRO L N   1 
ATOM   49   C  CA  . PRO A 1 7   ? -13.966 5.269   22.657  1.00 19.04  ? 8   PRO L CA  1 
ATOM   50   C  C   . PRO A 1 7   ? -12.906 5.286   21.558  1.00 21.01  ? 8   PRO L C   1 
ATOM   51   O  O   . PRO A 1 7   ? -12.796 4.314   20.813  1.00 19.08  ? 8   PRO L O   1 
ATOM   52   C  CB  . PRO A 1 7   ? -13.292 4.901   23.982  1.00 20.23  ? 8   PRO L CB  1 
ATOM   53   C  CG  . PRO A 1 7   ? -13.168 3.401   23.890  1.00 19.19  ? 8   PRO L CG  1 
ATOM   54   C  CD  . PRO A 1 7   ? -14.466 2.951   23.207  1.00 20.05  ? 8   PRO L CD  1 
ATOM   55   N  N   . SER A 1 8   ? -12.113 6.349   21.475  1.00 17.06  ? 9   SER L N   1 
ATOM   56   C  CA  . SER A 1 8   ? -11.050 6.410   20.485  1.00 19.68  ? 9   SER L CA  1 
ATOM   57   C  C   . SER A 1 8   ? -9.864  5.528   20.881  1.00 19.78  ? 9   SER L C   1 
ATOM   58   O  O   . SER A 1 8   ? -9.082  5.085   20.031  1.00 18.06  ? 9   SER L O   1 
ATOM   59   C  CB  . SER A 1 8   ? -10.611 7.866   20.271  1.00 22.18  ? 9   SER L CB  1 
ATOM   60   O  OG  . SER A 1 8   ? -9.845  8.307   21.376  1.00 34.93  ? 9   SER L OG  1 
ATOM   61   N  N   . SER A 1 9   ? -9.714  5.269   22.175  1.00 17.35  ? 10  SER L N   1 
ATOM   62   C  CA  . SER A 1 9   ? -8.701  4.319   22.634  1.00 19.33  ? 10  SER L CA  1 
ATOM   63   C  C   . SER A 1 9   ? -9.086  3.747   23.982  1.00 19.80  ? 10  SER L C   1 
ATOM   64   O  O   . SER A 1 9   ? -9.847  4.357   24.735  1.00 18.55  ? 10  SER L O   1 
ATOM   65   C  CB  . SER A 1 9   ? -7.313  4.960   22.728  1.00 22.13  ? 10  SER L CB  1 
ATOM   66   O  OG  . SER A 1 9   ? -7.316  6.039   23.651  1.00 33.64  ? 10  SER L OG  1 
ATOM   67   N  N   . VAL A 1 10  ? -8.557  2.563   24.276  1.00 16.28  ? 11  VAL L N   1 
ATOM   68   C  CA  . VAL A 1 10  ? -8.780  1.930   25.567  1.00 18.49  ? 11  VAL L CA  1 
ATOM   69   C  C   . VAL A 1 10  ? -7.605  1.005   25.877  1.00 18.83  ? 11  VAL L C   1 
ATOM   70   O  O   . VAL A 1 10  ? -7.029  0.396   24.973  1.00 17.59  ? 11  VAL L O   1 
ATOM   71   C  CB  . VAL A 1 10  ? -10.122 1.167   25.600  1.00 18.36  ? 11  VAL L CB  1 
ATOM   72   C  CG1 . VAL A 1 10  ? -10.113 0.015   24.585  1.00 17.93  ? 11  VAL L CG1 1 
ATOM   73   C  CG2 . VAL A 1 10  ? -10.420 0.623   27.008  1.00 19.92  ? 11  VAL L CG2 1 
ATOM   74   N  N   . SER A 1 11  ? -7.246  0.930   27.155  1.00 14.25  ? 12  SER L N   1 
ATOM   75   C  CA  . SER A 1 11  ? -6.246  0.001   27.661  1.00 15.04  ? 12  SER L CA  1 
ATOM   76   C  C   . SER A 1 11  ? -6.911  -1.022  28.593  1.00 15.29  ? 12  SER L C   1 
ATOM   77   O  O   . SER A 1 11  ? -7.644  -0.654  29.518  1.00 16.18  ? 12  SER L O   1 
ATOM   78   C  CB  . SER A 1 11  ? -5.158  0.766   28.426  1.00 21.08  ? 12  SER L CB  1 
ATOM   79   O  OG  . SER A 1 11  ? -4.294  -0.127  29.130  1.00 19.72  ? 12  SER L OG  1 
ATOM   80   N  N   . THR A 1 12  ? -6.669  -2.305  28.347  1.00 14.39  ? 13  THR L N   1 
ATOM   81   C  CA  . THR A 1 12  ? -7.360  -3.355  29.093  1.00 14.10  ? 13  THR L CA  1 
ATOM   82   C  C   . THR A 1 12  ? -6.439  -4.558  29.348  1.00 20.07  ? 13  THR L C   1 
ATOM   83   O  O   . THR A 1 12  ? -5.476  -4.791  28.598  1.00 18.27  ? 13  THR L O   1 
ATOM   84   C  CB  . THR A 1 12  ? -8.687  -3.767  28.348  1.00 17.05  ? 13  THR L CB  1 
ATOM   85   O  OG1 . THR A 1 12  ? -9.664  -4.257  29.283  1.00 17.11  ? 13  THR L OG1 1 
ATOM   86   C  CG2 . THR A 1 12  ? -8.412  -4.814  27.269  1.00 18.25  ? 13  THR L CG2 1 
ATOM   87   N  N   . ALA A 1 13  ? -6.709  -5.308  30.416  1.00 17.37  ? 14  ALA L N   1 
ATOM   88   C  CA  . ALA A 1 13  ? -5.802  -6.372  30.849  1.00 20.04  ? 14  ALA L CA  1 
ATOM   89   C  C   . ALA A 1 13  ? -6.001  -7.655  30.072  1.00 18.72  ? 14  ALA L C   1 
ATOM   90   O  O   . ALA A 1 13  ? -7.116  -7.929  29.613  1.00 17.11  ? 14  ALA L O   1 
ATOM   91   C  CB  . ALA A 1 13  ? -5.975  -6.650  32.346  1.00 20.79  ? 14  ALA L CB  1 
ATOM   92   N  N   . VAL A 1 14  ? -4.922  -8.432  29.902  1.00 14.70  ? 15  VAL L N   1 
ATOM   93   C  CA  . VAL A 1 14  ? -5.073  -9.801  29.396  1.00 15.69  ? 15  VAL L CA  1 
ATOM   94   C  C   . VAL A 1 14  ? -6.097  -10.523 30.285  1.00 21.23  ? 15  VAL L C   1 
ATOM   95   O  O   . VAL A 1 14  ? -6.000  -10.458 31.509  1.00 19.49  ? 15  VAL L O   1 
ATOM   96   C  CB  . VAL A 1 14  ? -3.760  -10.601 29.459  1.00 28.89  ? 15  VAL L CB  1 
ATOM   97   C  CG1 . VAL A 1 14  ? -4.029  -12.090 29.139  1.00 24.76  ? 15  VAL L CG1 1 
ATOM   98   C  CG2 . VAL A 1 14  ? -2.719  -10.021 28.499  1.00 23.25  ? 15  VAL L CG2 1 
ATOM   99   N  N   . GLY A 1 15  ? -7.080  -11.183 29.676  1.00 22.89  ? 16  GLY L N   1 
ATOM   100  C  CA  . GLY A 1 15  ? -8.058  -11.947 30.440  1.00 23.95  ? 16  GLY L CA  1 
ATOM   101  C  C   . GLY A 1 15  ? -9.317  -11.154 30.782  1.00 23.80  ? 16  GLY L C   1 
ATOM   102  O  O   . GLY A 1 15  ? -10.289 -11.702 31.292  1.00 20.73  ? 16  GLY L O   1 
ATOM   103  N  N   . SER A 1 16  ? -9.307  -9.856  30.505  1.00 16.64  ? 17  SER L N   1 
ATOM   104  C  CA  . SER A 1 16  ? -10.515 -9.059  30.679  1.00 17.37  ? 17  SER L CA  1 
ATOM   105  C  C   . SER A 1 16  ? -11.417 -9.228  29.457  1.00 15.60  ? 17  SER L C   1 
ATOM   106  O  O   . SER A 1 16  ? -11.080 -9.949  28.502  1.00 17.49  ? 17  SER L O   1 
ATOM   107  C  CB  . SER A 1 16  ? -10.175 -7.571  30.886  1.00 23.20  ? 17  SER L CB  1 
ATOM   108  O  OG  . SER A 1 16  ? -9.544  -7.002  29.731  1.00 20.17  ? 17  SER L OG  1 
ATOM   109  N  N   . ALA A 1 17  ? -12.578 -8.588  29.512  1.00 17.19  ? 18  ALA L N   1 
ATOM   110  C  CA  . ALA A 1 17  ? -13.410 -8.410  28.337  1.00 16.64  ? 18  ALA L CA  1 
ATOM   111  C  C   . ALA A 1 17  ? -13.440 -6.906  28.056  1.00 17.21  ? 18  ALA L C   1 
ATOM   112  O  O   . ALA A 1 17  ? -13.206 -6.100  28.970  1.00 17.50  ? 18  ALA L O   1 
ATOM   113  C  CB  . ALA A 1 17  ? -14.811 -8.968  28.586  1.00 20.22  ? 18  ALA L CB  1 
ATOM   114  N  N   . VAL A 1 18  ? -13.667 -6.526  26.792  1.00 18.09  ? 19  VAL L N   1 
ATOM   115  C  CA  . VAL A 1 18  ? -13.579 -5.119  26.385  1.00 16.26  ? 19  VAL L CA  1 
ATOM   116  C  C   . VAL A 1 18  ? -14.673 -4.798  25.357  1.00 16.72  ? 19  VAL L C   1 
ATOM   117  O  O   . VAL A 1 18  ? -14.951 -5.608  24.491  1.00 14.68  ? 19  VAL L O   1 
ATOM   118  C  CB  . VAL A 1 18  ? -12.153 -4.760  25.836  1.00 15.26  ? 19  VAL L CB  1 
ATOM   119  C  CG1 . VAL A 1 18  ? -11.848 -5.526  24.538  1.00 17.02  ? 19  VAL L CG1 1 
ATOM   120  C  CG2 . VAL A 1 18  ? -12.008 -3.258  25.625  1.00 14.95  ? 19  VAL L CG2 1 
ATOM   121  N  N   . THR A 1 19  ? -15.310 -3.633  25.471  1.00 18.50  ? 20  THR L N   1 
ATOM   122  C  CA  . THR A 1 19  ? -16.451 -3.294  24.601  1.00 15.29  ? 20  THR L CA  1 
ATOM   123  C  C   . THR A 1 19  ? -16.276 -1.949  23.864  1.00 17.96  ? 20  THR L C   1 
ATOM   124  O  O   . THR A 1 19  ? -15.797 -0.968  24.441  1.00 18.67  ? 20  THR L O   1 
ATOM   125  C  CB  . THR A 1 19  ? -17.789 -3.297  25.396  1.00 16.98  ? 20  THR L CB  1 
ATOM   126  O  OG1 . THR A 1 19  ? -18.000 -4.584  25.989  1.00 17.01  ? 20  THR L OG1 1 
ATOM   127  C  CG2 . THR A 1 19  ? -18.976 -2.980  24.487  1.00 19.74  ? 20  THR L CG2 1 
ATOM   128  N  N   . ILE A 1 20  ? -16.669 -1.922  22.589  1.00 17.80  ? 21  ILE L N   1 
ATOM   129  C  CA  . ILE A 1 20  ? -16.559 -0.742  21.732  1.00 21.87  ? 21  ILE L CA  1 
ATOM   130  C  C   . ILE A 1 20  ? -17.961 -0.402  21.208  1.00 21.21  ? 21  ILE L C   1 
ATOM   131  O  O   . ILE A 1 20  ? -18.754 -1.299  20.985  1.00 23.80  ? 21  ILE L O   1 
ATOM   132  C  CB  . ILE A 1 20  ? -15.610 -1.015  20.529  1.00 20.41  ? 21  ILE L CB  1 
ATOM   133  C  CG1 . ILE A 1 20  ? -14.179 -1.250  21.011  1.00 25.42  ? 21  ILE L CG1 1 
ATOM   134  C  CG2 . ILE A 1 20  ? -15.612 0.159   19.541  1.00 30.29  ? 21  ILE L CG2 1 
ATOM   135  C  CD1 . ILE A 1 20  ? -13.243 -1.635  19.883  1.00 35.22  ? 21  ILE L CD1 1 
ATOM   136  N  N   . ASN A 1 21  ? -18.266 0.882   21.006  1.00 22.40  ? 22  ASN L N   1 
ATOM   137  C  CA  . ASN A 1 21  ? -19.616 1.303   20.608  1.00 19.23  ? 22  ASN L CA  1 
ATOM   138  C  C   . ASN A 1 21  ? -19.599 2.010   19.258  1.00 22.25  ? 22  ASN L C   1 
ATOM   139  O  O   . ASN A 1 21  ? -18.631 2.672   18.915  1.00 18.58  ? 22  ASN L O   1 
ATOM   140  C  CB  . ASN A 1 21  ? -20.219 2.234   21.683  1.00 19.68  ? 22  ASN L CB  1 
ATOM   141  C  CG  . ASN A 1 21  ? -21.723 2.515   21.466  1.00 37.09  ? 22  ASN L CG  1 
ATOM   142  O  OD1 . ASN A 1 21  ? -22.582 1.696   21.813  1.00 36.03  ? 22  ASN L OD1 1 
ATOM   143  N  ND2 . ASN A 1 21  ? -22.038 3.690   20.910  1.00 33.31  ? 22  ASN L ND2 1 
ATOM   144  N  N   . CYS A 1 22  ? -20.665 1.853   18.482  1.00 20.60  ? 23  CYS L N   1 
ATOM   145  C  CA  . CYS A 1 22  ? -20.832 2.635   17.262  1.00 20.62  ? 23  CYS L CA  1 
ATOM   146  C  C   . CYS A 1 22  ? -22.271 3.110   17.139  1.00 24.24  ? 23  CYS L C   1 
ATOM   147  O  O   . CYS A 1 22  ? -23.201 2.317   17.242  1.00 24.54  ? 23  CYS L O   1 
ATOM   148  C  CB  . CYS A 1 22  ? -20.404 1.863   16.000  1.00 21.78  ? 23  CYS L CB  1 
ATOM   149  S  SG  . CYS A 1 22  ? -18.627 1.967   15.650  1.00 30.81  ? 23  CYS L SG  1 
ATOM   150  N  N   . GLN A 1 23  ? -22.423 4.412   16.916  1.00 21.63  ? 24  GLN L N   1 
ATOM   151  C  CA  . GLN A 1 23  ? -23.714 5.076   16.877  1.00 24.40  ? 24  GLN L CA  1 
ATOM   152  C  C   . GLN A 1 23  ? -23.865 5.784   15.527  1.00 24.42  ? 24  GLN L C   1 
ATOM   153  O  O   . GLN A 1 23  ? -22.988 6.565   15.121  1.00 23.60  ? 24  GLN L O   1 
ATOM   154  C  CB  . GLN A 1 23  ? -23.793 6.098   18.022  1.00 20.29  ? 24  GLN L CB  1 
ATOM   155  C  CG  . GLN A 1 23  ? -25.005 6.987   17.960  1.00 35.82  ? 24  GLN L CG  1 
ATOM   156  C  CD  . GLN A 1 23  ? -26.221 6.332   18.571  1.00 52.14  ? 24  GLN L CD  1 
ATOM   157  O  OE1 . GLN A 1 23  ? -26.103 5.487   19.465  1.00 51.24  ? 24  GLN L OE1 1 
ATOM   158  N  NE2 . GLN A 1 23  ? -27.406 6.714   18.090  1.00 57.74  ? 24  GLN L NE2 1 
ATOM   159  N  N   . SER A 1 24  ? -24.976 5.525   14.842  1.00 20.35  ? 25  SER L N   1 
ATOM   160  C  CA  . SER A 1 24  ? -25.157 5.977   13.455  1.00 19.12  ? 25  SER L CA  1 
ATOM   161  C  C   . SER A 1 24  ? -26.171 7.120   13.376  1.00 23.85  ? 25  SER L C   1 
ATOM   162  O  O   . SER A 1 24  ? -27.167 7.120   14.093  1.00 23.39  ? 25  SER L O   1 
ATOM   163  C  CB  . SER A 1 24  ? -25.600 4.792   12.579  1.00 21.59  ? 25  SER L CB  1 
ATOM   164  O  OG  . SER A 1 24  ? -25.711 5.152   11.214  1.00 16.71  ? 25  SER L OG  1 
ATOM   165  N  N   . SER A 1 25  ? -25.911 8.093   12.508  1.00 19.61  ? 26  SER L N   1 
ATOM   166  C  CA  . SER A 1 25  ? -26.814 9.234   12.298  1.00 28.39  ? 26  SER L CA  1 
ATOM   167  C  C   . SER A 1 25  ? -28.136 8.853   11.615  1.00 22.70  ? 26  SER L C   1 
ATOM   168  O  O   . SER A 1 25  ? -29.078 9.643   11.608  1.00 25.39  ? 26  SER L O   1 
ATOM   169  C  CB  . SER A 1 25  ? -26.119 10.323  11.472  1.00 20.65  ? 26  SER L CB  1 
ATOM   170  O  OG  . SER A 1 25  ? -25.807 9.814   10.177  1.00 18.79  ? 26  SER L OG  1 
ATOM   171  N  N   . GLN A 1 26  ? -28.192 7.651   11.045  1.00 18.30  ? 27  GLN L N   1 
ATOM   172  C  CA  . GLN A 1 26  ? -29.399 7.137   10.380  1.00 27.19  ? 27  GLN L CA  1 
ATOM   173  C  C   . GLN A 1 26  ? -29.350 5.612   10.432  1.00 25.33  ? 27  GLN L C   1 
ATOM   174  O  O   . GLN A 1 26  ? -28.274 5.041   10.636  1.00 22.45  ? 27  GLN L O   1 
ATOM   175  C  CB  . GLN A 1 26  ? -29.484 7.615   8.924   1.00 26.23  ? 27  GLN L CB  1 
ATOM   176  C  CG  . GLN A 1 26  ? -28.524 6.879   7.968   1.00 21.32  ? 27  GLN L CG  1 
ATOM   177  C  CD  . GLN A 1 26  ? -28.445 7.516   6.575   1.00 31.12  ? 27  GLN L CD  1 
ATOM   178  O  OE1 . GLN A 1 26  ? -28.740 6.859   5.574   1.00 27.52  ? 27  GLN L OE1 1 
ATOM   179  N  NE2 . GLN A 1 26  ? -28.043 8.793   6.509   1.00 23.94  ? 27  GLN L NE2 1 
ATOM   180  N  N   . ASN A 1 27  A -30.500 4.947   10.291  1.00 24.42  ? 27  ASN L N   1 
ATOM   181  C  CA  . ASN A 1 27  A -30.520 3.481   10.308  1.00 22.84  ? 27  ASN L CA  1 
ATOM   182  C  C   . ASN A 1 27  A -29.668 2.931   9.185   1.00 22.81  ? 27  ASN L C   1 
ATOM   183  O  O   . ASN A 1 27  A -29.709 3.447   8.063   1.00 22.32  ? 27  ASN L O   1 
ATOM   184  C  CB  . ASN A 1 27  A -31.944 2.934   10.155  1.00 20.25  ? 27  ASN L CB  1 
ATOM   185  C  CG  . ASN A 1 27  A -32.818 3.241   11.355  1.00 36.44  ? 27  ASN L CG  1 
ATOM   186  O  OD1 . ASN A 1 27  A -33.256 4.373   11.543  1.00 41.99  ? 27  ASN L OD1 1 
ATOM   187  N  ND2 . ASN A 1 27  A -33.068 2.234   12.174  1.00 34.41  ? 27  ASN L ND2 1 
ATOM   188  N  N   . VAL A 1 28  B -28.901 1.890   9.485   1.00 26.27  ? 27  VAL L N   1 
ATOM   189  C  CA  . VAL A 1 28  B -28.164 1.176   8.455   1.00 26.74  ? 27  VAL L CA  1 
ATOM   190  C  C   . VAL A 1 28  B -29.154 0.388   7.602   1.00 28.44  ? 27  VAL L C   1 
ATOM   191  O  O   . VAL A 1 28  B -30.300 0.176   8.009   1.00 22.52  ? 27  VAL L O   1 
ATOM   192  C  CB  . VAL A 1 28  B -27.109 0.234   9.056   1.00 18.08  ? 27  VAL L CB  1 
ATOM   193  C  CG1 . VAL A 1 28  B -26.059 1.044   9.809   1.00 17.16  ? 27  VAL L CG1 1 
ATOM   194  C  CG2 . VAL A 1 28  B -27.763 -0.804  9.961   1.00 18.97  ? 27  VAL L CG2 1 
ATOM   195  N  N   . TYR A 1 29  ? -28.718 -0.040  6.422   1.00 23.31  ? 28  TYR L N   1 
ATOM   196  C  CA  . TYR A 1 29  ? -29.613 -0.726  5.494   1.00 24.24  ? 28  TYR L CA  1 
ATOM   197  C  C   . TYR A 1 29  ? -30.178 -2.011  6.110   1.00 25.01  ? 28  TYR L C   1 
ATOM   198  O  O   . TYR A 1 29  ? -29.441 -2.794  6.708   1.00 24.11  ? 28  TYR L O   1 
ATOM   199  C  CB  . TYR A 1 29  ? -28.897 -1.009  4.172   1.00 22.45  ? 28  TYR L CB  1 
ATOM   200  C  CG  . TYR A 1 29  ? -29.797 -1.610  3.115   1.00 26.94  ? 28  TYR L CG  1 
ATOM   201  C  CD1 . TYR A 1 29  ? -29.729 -2.961  2.802   1.00 29.83  ? 28  TYR L CD1 1 
ATOM   202  C  CD2 . TYR A 1 29  ? -30.720 -0.829  2.441   1.00 31.27  ? 28  TYR L CD2 1 
ATOM   203  C  CE1 . TYR A 1 29  ? -30.551 -3.512  1.838   1.00 38.28  ? 28  TYR L CE1 1 
ATOM   204  C  CE2 . TYR A 1 29  ? -31.553 -1.375  1.479   1.00 34.81  ? 28  TYR L CE2 1 
ATOM   205  C  CZ  . TYR A 1 29  ? -31.461 -2.714  1.182   1.00 31.70  ? 28  TYR L CZ  1 
ATOM   206  O  OH  . TYR A 1 29  ? -32.286 -3.254  0.220   1.00 48.44  ? 28  TYR L OH  1 
ATOM   207  N  N   . SER A 1 30  ? -31.497 -2.196  5.993   1.00 28.15  ? 29  SER L N   1 
ATOM   208  C  CA  . SER A 1 30  ? -32.198 -3.330  6.618   1.00 26.54  ? 29  SER L CA  1 
ATOM   209  C  C   . SER A 1 30  ? -31.973 -3.423  8.120   1.00 23.91  ? 29  SER L C   1 
ATOM   210  O  O   . SER A 1 30  ? -32.084 -4.506  8.691   1.00 29.17  ? 29  SER L O   1 
ATOM   211  C  CB  . SER A 1 30  ? -31.778 -4.676  6.004   1.00 26.87  ? 29  SER L CB  1 
ATOM   212  O  OG  . SER A 1 30  ? -31.886 -4.662  4.601   1.00 40.92  ? 29  SER L OG  1 
ATOM   213  N  N   . ASN A 1 31  ? -31.641 -2.303  8.748   1.00 21.53  ? 30  ASN L N   1 
ATOM   214  C  CA  . ASN A 1 31  ? -31.337 -2.259  10.186  1.00 30.31  ? 30  ASN L CA  1 
ATOM   215  C  C   . ASN A 1 31  ? -30.172 -3.113  10.667  1.00 20.93  ? 30  ASN L C   1 
ATOM   216  O  O   . ASN A 1 31  ? -29.841 -3.061  11.854  1.00 24.87  ? 30  ASN L O   1 
ATOM   217  C  CB  . ASN A 1 31  ? -32.576 -2.566  11.052  1.00 25.36  ? 30  ASN L CB  1 
ATOM   218  C  CG  . ASN A 1 31  ? -33.601 -1.466  11.020  1.00 31.54  ? 30  ASN L CG  1 
ATOM   219  O  OD1 . ASN A 1 31  ? -33.272 -0.283  11.052  1.00 32.16  ? 30  ASN L OD1 1 
ATOM   220  N  ND2 . ASN A 1 31  ? -34.870 -1.851  10.960  1.00 45.92  ? 30  ASN L ND2 1 
ATOM   221  N  N   . ASN A 1 32  ? -29.539 -3.894  9.790   1.00 22.43  ? 31  ASN L N   1 
ATOM   222  C  CA  . ASN A 1 32  ? -28.386 -4.687  10.232  1.00 19.57  ? 31  ASN L CA  1 
ATOM   223  C  C   . ASN A 1 32  ? -27.141 -4.745  9.327   1.00 23.78  ? 31  ASN L C   1 
ATOM   224  O  O   . ASN A 1 32  ? -26.261 -5.554  9.569   1.00 20.67  ? 31  ASN L O   1 
ATOM   225  C  CB  . ASN A 1 32  ? -28.814 -6.125  10.554  1.00 24.65  ? 31  ASN L CB  1 
ATOM   226  C  CG  . ASN A 1 32  ? -29.137 -6.915  9.309   1.00 26.31  ? 31  ASN L CG  1 
ATOM   227  O  OD1 . ASN A 1 32  ? -29.369 -6.336  8.252   1.00 23.58  ? 31  ASN L OD1 1 
ATOM   228  N  ND2 . ASN A 1 32  ? -29.154 -8.240  9.423   1.00 32.13  ? 31  ASN L ND2 1 
ATOM   229  N  N   . ASN A 1 33  ? -27.054 -3.907  8.299   1.00 19.42  ? 32  ASN L N   1 
ATOM   230  C  CA  . ASN A 1 33  ? -25.882 -3.950  7.426   1.00 17.50  ? 32  ASN L CA  1 
ATOM   231  C  C   . ASN A 1 33  ? -24.756 -3.200  8.109   1.00 20.60  ? 32  ASN L C   1 
ATOM   232  O  O   . ASN A 1 33  ? -24.531 -2.005  7.833   1.00 17.40  ? 32  ASN L O   1 
ATOM   233  C  CB  . ASN A 1 33  ? -26.195 -3.332  6.057   1.00 18.91  ? 32  ASN L CB  1 
ATOM   234  C  CG  . ASN A 1 33  ? -25.197 -3.746  4.974   1.00 21.09  ? 32  ASN L CG  1 
ATOM   235  O  OD1 . ASN A 1 33  ? -24.416 -4.682  5.143   1.00 20.73  ? 32  ASN L OD1 1 
ATOM   236  N  ND2 . ASN A 1 33  ? -25.238 -3.047  3.837   1.00 21.62  ? 32  ASN L ND2 1 
ATOM   237  N  N   . LEU A 1 34  ? -24.072 -3.899  9.018   1.00 18.91  ? 33  LEU L N   1 
ATOM   238  C  CA  . LEU A 1 34  ? -23.030 -3.300  9.867   1.00 20.85  ? 33  LEU L CA  1 
ATOM   239  C  C   . LEU A 1 34  ? -21.975 -4.350  10.166  1.00 20.57  ? 33  LEU L C   1 
ATOM   240  O  O   . LEU A 1 34  ? -22.304 -5.492  10.508  1.00 23.23  ? 33  LEU L O   1 
ATOM   241  C  CB  . LEU A 1 34  ? -23.640 -2.764  11.171  1.00 20.96  ? 33  LEU L CB  1 
ATOM   242  C  CG  . LEU A 1 34  ? -22.900 -1.923  12.248  1.00 25.02  ? 33  LEU L CG  1 
ATOM   243  C  CD1 . LEU A 1 34  ? -21.809 -2.682  13.028  1.00 18.68  ? 33  LEU L CD1 1 
ATOM   244  C  CD2 . LEU A 1 34  ? -22.375 -0.592  11.708  1.00 20.27  ? 33  LEU L CD2 1 
ATOM   245  N  N   . ALA A 1 35  ? -20.709 -3.971  10.033  1.00 19.21  ? 34  ALA L N   1 
ATOM   246  C  CA  . ALA A 1 35  ? -19.612 -4.918  10.178  1.00 19.76  ? 34  ALA L CA  1 
ATOM   247  C  C   . ALA A 1 35  ? -18.478 -4.387  11.076  1.00 19.66  ? 34  ALA L C   1 
ATOM   248  O  O   . ALA A 1 35  ? -18.331 -3.175  11.257  1.00 17.92  ? 34  ALA L O   1 
ATOM   249  C  CB  . ALA A 1 35  ? -19.080 -5.321  8.795   1.00 20.45  ? 34  ALA L CB  1 
ATOM   250  N  N   . TRP A 1 36  ? -17.705 -5.297  11.657  1.00 15.57  ? 35  TRP L N   1 
ATOM   251  C  CA  . TRP A 1 36  ? -16.546 -4.916  12.473  1.00 17.02  ? 35  TRP L CA  1 
ATOM   252  C  C   . TRP A 1 36  ? -15.246 -5.527  11.940  1.00 16.38  ? 35  TRP L C   1 
ATOM   253  O  O   . TRP A 1 36  ? -15.226 -6.686  11.517  1.00 17.80  ? 35  TRP L O   1 
ATOM   254  C  CB  . TRP A 1 36  ? -16.743 -5.366  13.912  1.00 18.15  ? 35  TRP L CB  1 
ATOM   255  C  CG  . TRP A 1 36  ? -17.889 -4.710  14.612  1.00 18.00  ? 35  TRP L CG  1 
ATOM   256  C  CD1 . TRP A 1 36  ? -19.193 -5.140  14.650  1.00 18.81  ? 35  TRP L CD1 1 
ATOM   257  C  CD2 . TRP A 1 36  ? -17.834 -3.502  15.379  1.00 17.29  ? 35  TRP L CD2 1 
ATOM   258  N  NE1 . TRP A 1 36  ? -19.949 -4.271  15.413  1.00 18.44  ? 35  TRP L NE1 1 
ATOM   259  C  CE2 . TRP A 1 36  ? -19.138 -3.257  15.865  1.00 17.31  ? 35  TRP L CE2 1 
ATOM   260  C  CE3 . TRP A 1 36  ? -16.799 -2.612  15.720  1.00 16.99  ? 35  TRP L CE3 1 
ATOM   261  C  CZ2 . TRP A 1 36  ? -19.436 -2.162  16.673  1.00 17.73  ? 35  TRP L CZ2 1 
ATOM   262  C  CZ3 . TRP A 1 36  ? -17.094 -1.525  16.513  1.00 18.66  ? 35  TRP L CZ3 1 
ATOM   263  C  CH2 . TRP A 1 36  ? -18.408 -1.302  16.981  1.00 17.79  ? 35  TRP L CH2 1 
ATOM   264  N  N   . PHE A 1 37  ? -14.170 -4.745  11.988  1.00 17.15  ? 36  PHE L N   1 
ATOM   265  C  CA  . PHE A 1 37  ? -12.856 -5.139  11.455  1.00 13.95  ? 36  PHE L CA  1 
ATOM   266  C  C   . PHE A 1 37  ? -11.763 -4.983  12.487  1.00 14.71  ? 36  PHE L C   1 
ATOM   267  O  O   . PHE A 1 37  ? -11.855 -4.138  13.369  1.00 16.24  ? 36  PHE L O   1 
ATOM   268  C  CB  . PHE A 1 37  ? -12.460 -4.248  10.269  1.00 16.00  ? 36  PHE L CB  1 
ATOM   269  C  CG  . PHE A 1 37  ? -13.373 -4.369  9.086   1.00 14.41  ? 36  PHE L CG  1 
ATOM   270  C  CD1 . PHE A 1 37  ? -14.556 -3.644  9.024   1.00 17.41  ? 36  PHE L CD1 1 
ATOM   271  C  CD2 . PHE A 1 37  ? -13.061 -5.226  8.047   1.00 17.92  ? 36  PHE L CD2 1 
ATOM   272  C  CE1 . PHE A 1 37  ? -15.399 -3.758  7.924   1.00 17.55  ? 36  PHE L CE1 1 
ATOM   273  C  CE2 . PHE A 1 37  ? -13.906 -5.351  6.941   1.00 15.02  ? 36  PHE L CE2 1 
ATOM   274  C  CZ  . PHE A 1 37  ? -15.078 -4.617  6.888   1.00 15.54  ? 36  PHE L CZ  1 
ATOM   275  N  N   . GLN A 1 38  ? -10.700 -5.763  12.322  1.00 16.64  ? 37  GLN L N   1 
ATOM   276  C  CA  . GLN A 1 38  ? -9.461  -5.592  13.077  1.00 21.29  ? 37  GLN L CA  1 
ATOM   277  C  C   . GLN A 1 38  ? -8.354  -5.219  12.097  1.00 22.83  ? 37  GLN L C   1 
ATOM   278  O  O   . GLN A 1 38  ? -8.263  -5.814  11.030  1.00 18.73  ? 37  GLN L O   1 
ATOM   279  C  CB  . GLN A 1 38  ? -9.069  -6.914  13.746  1.00 16.69  ? 37  GLN L CB  1 
ATOM   280  C  CG  . GLN A 1 38  ? -7.806  -6.856  14.590  1.00 16.71  ? 37  GLN L CG  1 
ATOM   281  C  CD  . GLN A 1 38  ? -7.354  -8.254  15.068  1.00 27.44  ? 37  GLN L CD  1 
ATOM   282  O  OE1 . GLN A 1 38  ? -7.400  -9.224  14.315  1.00 23.38  ? 37  GLN L OE1 1 
ATOM   283  N  NE2 . GLN A 1 38  ? -6.914  -8.343  16.318  1.00 20.23  ? 37  GLN L NE2 1 
ATOM   284  N  N   . GLN A 1 39  ? -7.515  -4.248  12.453  1.00 17.35  ? 38  GLN L N   1 
ATOM   285  C  CA  . GLN A 1 39  ? -6.357  -3.914  11.618  1.00 20.02  ? 38  GLN L CA  1 
ATOM   286  C  C   . GLN A 1 39  ? -5.090  -3.743  12.450  1.00 24.15  ? 38  GLN L C   1 
ATOM   287  O  O   . GLN A 1 39  ? -5.054  -2.938  13.389  1.00 21.52  ? 38  GLN L O   1 
ATOM   288  C  CB  . GLN A 1 39  ? -6.596  -2.624  10.815  1.00 16.81  ? 38  GLN L CB  1 
ATOM   289  C  CG  . GLN A 1 39  ? -5.454  -2.295  9.854   1.00 17.00  ? 38  GLN L CG  1 
ATOM   290  C  CD  . GLN A 1 39  ? -5.610  -0.947  9.150   1.00 24.30  ? 38  GLN L CD  1 
ATOM   291  O  OE1 . GLN A 1 39  ? -6.162  0.008   9.707   1.00 22.17  ? 38  GLN L OE1 1 
ATOM   292  N  NE2 . GLN A 1 39  ? -5.137  -0.874  7.914   1.00 21.50  ? 38  GLN L NE2 1 
ATOM   293  N  N   . LYS A 1 40  ? -4.053  -4.495  12.097  1.00 24.05  ? 39  LYS L N   1 
ATOM   294  C  CA  . LYS A 1 40  ? -2.738  -4.323  12.706  1.00 25.59  ? 39  LYS L CA  1 
ATOM   295  C  C   . LYS A 1 40  ? -1.863  -3.483  11.794  1.00 28.73  ? 39  LYS L C   1 
ATOM   296  O  O   . LYS A 1 40  ? -2.128  -3.415  10.603  1.00 28.36  ? 39  LYS L O   1 
ATOM   297  C  CB  . LYS A 1 40  ? -2.097  -5.689  12.972  1.00 29.15  ? 39  LYS L CB  1 
ATOM   298  C  CG  . LYS A 1 40  ? -2.823  -6.460  14.055  1.00 28.75  ? 39  LYS L CG  1 
ATOM   299  C  CD  . LYS A 1 40  ? -2.077  -7.694  14.465  1.00 32.77  ? 39  LYS L CD  1 
ATOM   300  C  CE  . LYS A 1 40  ? -2.737  -8.297  15.687  1.00 33.23  ? 39  LYS L CE  1 
ATOM   301  N  NZ  . LYS A 1 40  ? -2.046  -9.530  16.149  1.00 25.00  ? 39  LYS L NZ  1 
ATOM   302  N  N   . PRO A 1 41  ? -0.827  -2.822  12.357  1.00 32.91  ? 40  PRO L N   1 
ATOM   303  C  CA  . PRO A 1 41  ? 0.037   -1.929  11.569  1.00 33.39  ? 40  PRO L CA  1 
ATOM   304  C  C   . PRO A 1 41  ? 0.658   -2.605  10.347  1.00 33.21  ? 40  PRO L C   1 
ATOM   305  O  O   . PRO A 1 41  ? 1.153   -3.733  10.450  1.00 29.79  ? 40  PRO L O   1 
ATOM   306  C  CB  . PRO A 1 41  ? 1.124   -1.523  12.571  1.00 40.09  ? 40  PRO L CB  1 
ATOM   307  C  CG  . PRO A 1 41  ? 0.450   -1.596  13.890  1.00 35.74  ? 40  PRO L CG  1 
ATOM   308  C  CD  . PRO A 1 41  ? -0.485  -2.780  13.792  1.00 36.63  ? 40  PRO L CD  1 
ATOM   309  N  N   . GLY A 1 42  ? 0.597   -1.919  9.203   1.00 32.88  ? 41  GLY L N   1 
ATOM   310  C  CA  . GLY A 1 42  ? 1.141   -2.419  7.950   1.00 31.79  ? 41  GLY L CA  1 
ATOM   311  C  C   . GLY A 1 42  ? 0.303   -3.466  7.233   1.00 33.58  ? 41  GLY L C   1 
ATOM   312  O  O   . GLY A 1 42  ? 0.681   -3.953  6.163   1.00 36.30  ? 41  GLY L O   1 
ATOM   313  N  N   . GLN A 1 43  ? -0.835  -3.816  7.819   1.00 24.37  ? 42  GLN L N   1 
ATOM   314  C  CA  . GLN A 1 43  ? -1.702  -4.859  7.279   1.00 30.54  ? 42  GLN L CA  1 
ATOM   315  C  C   . GLN A 1 43  ? -3.057  -4.312  6.812   1.00 20.56  ? 42  GLN L C   1 
ATOM   316  O  O   . GLN A 1 43  ? -3.479  -3.254  7.263   1.00 20.27  ? 42  GLN L O   1 
ATOM   317  C  CB  . GLN A 1 43  ? -1.944  -5.905  8.362   1.00 32.01  ? 42  GLN L CB  1 
ATOM   318  C  CG  . GLN A 1 43  ? -0.680  -6.574  8.828   1.00 33.10  ? 42  GLN L CG  1 
ATOM   319  C  CD  . GLN A 1 43  ? -0.720  -8.053  8.570   1.00 61.51  ? 42  GLN L CD  1 
ATOM   320  O  OE1 . GLN A 1 43  ? -1.200  -8.824  9.406   1.00 68.61  ? 42  GLN L OE1 1 
ATOM   321  N  NE2 . GLN A 1 43  ? -0.232  -8.465  7.399   1.00 54.49  ? 42  GLN L NE2 1 
ATOM   322  N  N   . PRO A 1 44  ? -3.740  -5.042  5.912   1.00 17.44  ? 43  PRO L N   1 
ATOM   323  C  CA  . PRO A 1 44  ? -5.114  -4.666  5.564   1.00 23.00  ? 43  PRO L CA  1 
ATOM   324  C  C   . PRO A 1 44  ? -6.070  -5.052  6.699   1.00 20.83  ? 43  PRO L C   1 
ATOM   325  O  O   . PRO A 1 44  ? -5.740  -5.926  7.504   1.00 23.45  ? 43  PRO L O   1 
ATOM   326  C  CB  . PRO A 1 44  ? -5.414  -5.527  4.328   1.00 25.12  ? 43  PRO L CB  1 
ATOM   327  C  CG  . PRO A 1 44  ? -4.524  -6.736  4.487   1.00 27.34  ? 43  PRO L CG  1 
ATOM   328  C  CD  . PRO A 1 44  ? -3.270  -6.219  5.152   1.00 25.66  ? 43  PRO L CD  1 
ATOM   329  N  N   . PRO A 1 45  ? -7.243  -4.415  6.752   1.00 20.49  ? 44  PRO L N   1 
ATOM   330  C  CA  . PRO A 1 45  ? -8.313  -4.783  7.681   1.00 16.46  ? 44  PRO L CA  1 
ATOM   331  C  C   . PRO A 1 45  ? -8.736  -6.228  7.486   1.00 19.99  ? 44  PRO L C   1 
ATOM   332  O  O   . PRO A 1 45  ? -8.664  -6.733  6.365   1.00 22.45  ? 44  PRO L O   1 
ATOM   333  C  CB  . PRO A 1 45  ? -9.468  -3.867  7.255   1.00 22.18  ? 44  PRO L CB  1 
ATOM   334  C  CG  . PRO A 1 45  ? -8.824  -2.739  6.561   1.00 21.71  ? 44  PRO L CG  1 
ATOM   335  C  CD  . PRO A 1 45  ? -7.638  -3.308  5.868   1.00 18.41  ? 44  PRO L CD  1 
ATOM   336  N  N   . ARG A 1 46  ? -9.218  -6.857  8.554   1.00 21.21  ? 45  ARG L N   1 
ATOM   337  C  CA  . ARG A 1 46  ? -9.685  -8.246  8.536   1.00 17.13  ? 45  ARG L CA  1 
ATOM   338  C  C   . ARG A 1 46  ? -11.136 -8.245  9.024   1.00 18.05  ? 45  ARG L C   1 
ATOM   339  O  O   . ARG A 1 46  ? -11.428 -7.708  10.087  1.00 18.95  ? 45  ARG L O   1 
ATOM   340  C  CB  . ARG A 1 46  ? -8.814  -9.068  9.488   1.00 26.92  ? 45  ARG L CB  1 
ATOM   341  C  CG  . ARG A 1 46  ? -9.272  -10.513 9.758   1.00 28.24  ? 45  ARG L CG  1 
ATOM   342  C  CD  . ARG A 1 46  ? -8.620  -11.025 11.042  1.00 30.57  ? 45  ARG L CD  1 
ATOM   343  N  NE  . ARG A 1 46  ? -8.903  -12.431 11.335  1.00 37.83  ? 45  ARG L NE  1 
ATOM   344  C  CZ  . ARG A 1 46  ? -8.742  -12.991 12.531  1.00 40.13  ? 45  ARG L CZ  1 
ATOM   345  N  NH1 . ARG A 1 46  ? -9.029  -14.274 12.703  1.00 36.71  ? 45  ARG L NH1 1 
ATOM   346  N  NH2 . ARG A 1 46  ? -8.306  -12.271 13.562  1.00 34.16  ? 45  ARG L NH2 1 
ATOM   347  N  N   . LEU A 1 47  ? -12.046 -8.803  8.234   1.00 13.89  ? 46  LEU L N   1 
ATOM   348  C  CA  . LEU A 1 47  ? -13.451 -8.849  8.602   1.00 20.21  ? 46  LEU L CA  1 
ATOM   349  C  C   . LEU A 1 47  ? -13.657 -9.806  9.778   1.00 21.36  ? 46  LEU L C   1 
ATOM   350  O  O   . LEU A 1 47  ? -13.245 -10.959 9.708   1.00 20.66  ? 46  LEU L O   1 
ATOM   351  C  CB  . LEU A 1 47  ? -14.303 -9.309  7.410   1.00 16.79  ? 46  LEU L CB  1 
ATOM   352  C  CG  . LEU A 1 47  ? -15.813 -9.433  7.642   1.00 20.09  ? 46  LEU L CG  1 
ATOM   353  C  CD1 . LEU A 1 47  ? -16.395 -8.077  7.984   1.00 17.35  ? 46  LEU L CD1 1 
ATOM   354  C  CD2 . LEU A 1 47  ? -16.527 -10.037 6.433   1.00 21.12  ? 46  LEU L CD2 1 
ATOM   355  N  N   . LEU A 1 48  ? -14.304 -9.328  10.844  1.00 18.61  ? 47  LEU L N   1 
ATOM   356  C  CA  . LEU A 1 48  ? -14.566 -10.145 12.025  1.00 19.04  ? 47  LEU L CA  1 
ATOM   357  C  C   . LEU A 1 48  ? -16.056 -10.524 12.136  1.00 24.17  ? 47  LEU L C   1 
ATOM   358  O  O   . LEU A 1 48  ? -16.393 -11.697 12.331  1.00 19.59  ? 47  LEU L O   1 
ATOM   359  C  CB  . LEU A 1 48  ? -14.125 -9.407  13.296  1.00 17.49  ? 47  LEU L CB  1 
ATOM   360  C  CG  . LEU A 1 48  ? -12.648 -9.005  13.435  1.00 25.56  ? 47  LEU L CG  1 
ATOM   361  C  CD1 . LEU A 1 48  ? -12.425 -8.173  14.705  1.00 20.29  ? 47  LEU L CD1 1 
ATOM   362  C  CD2 . LEU A 1 48  ? -11.714 -10.219 13.441  1.00 20.64  ? 47  LEU L CD2 1 
ATOM   363  N  N   . ILE A 1 49  ? -16.931 -9.521  12.020  1.00 22.12  ? 48  ILE L N   1 
ATOM   364  C  CA  . ILE A 1 49  ? -18.379 -9.693  12.173  1.00 21.51  ? 48  ILE L CA  1 
ATOM   365  C  C   . ILE A 1 49  ? -19.077 -8.980  11.023  1.00 23.95  ? 48  ILE L C   1 
ATOM   366  O  O   . ILE A 1 49  ? -18.657 -7.889  10.648  1.00 23.96  ? 48  ILE L O   1 
ATOM   367  C  CB  . ILE A 1 49  ? -18.874 -9.013  13.469  1.00 19.97  ? 48  ILE L CB  1 
ATOM   368  C  CG1 . ILE A 1 49  ? -18.088 -9.490  14.702  1.00 25.05  ? 48  ILE L CG1 1 
ATOM   369  C  CG2 . ILE A 1 49  ? -20.384 -9.213  13.651  1.00 22.49  ? 48  ILE L CG2 1 
ATOM   370  C  CD1 . ILE A 1 49  ? -18.491 -10.866 15.213  1.00 30.81  ? 48  ILE L CD1 1 
ATOM   371  N  N   . TYR A 1 50  ? -20.138 -9.570  10.476  1.00 22.15  ? 49  TYR L N   1 
ATOM   372  C  CA  . TYR A 1 50  ? -20.995 -8.863  9.514   1.00 18.17  ? 49  TYR L CA  1 
ATOM   373  C  C   . TYR A 1 50  ? -22.464 -9.101  9.848   1.00 24.77  ? 49  TYR L C   1 
ATOM   374  O  O   . TYR A 1 50  ? -22.792 -9.953  10.690  1.00 21.16  ? 49  TYR L O   1 
ATOM   375  C  CB  . TYR A 1 50  ? -20.695 -9.265  8.065   1.00 21.46  ? 49  TYR L CB  1 
ATOM   376  C  CG  . TYR A 1 50  ? -20.990 -10.712 7.760   1.00 26.01  ? 49  TYR L CG  1 
ATOM   377  C  CD1 . TYR A 1 50  ? -20.068 -11.712 8.059   1.00 30.66  ? 49  TYR L CD1 1 
ATOM   378  C  CD2 . TYR A 1 50  ? -22.187 -11.085 7.171   1.00 30.47  ? 49  TYR L CD2 1 
ATOM   379  C  CE1 . TYR A 1 50  ? -20.345 -13.047 7.782   1.00 31.21  ? 49  TYR L CE1 1 
ATOM   380  C  CE2 . TYR A 1 50  ? -22.469 -12.414 6.895   1.00 35.40  ? 49  TYR L CE2 1 
ATOM   381  C  CZ  . TYR A 1 50  ? -21.548 -13.387 7.206   1.00 35.08  ? 49  TYR L CZ  1 
ATOM   382  O  OH  . TYR A 1 50  ? -21.837 -14.703 6.929   1.00 44.14  ? 49  TYR L OH  1 
ATOM   383  N  N   . ASP A 1 51  ? -23.345 -8.333  9.205   1.00 21.41  ? 50  ASP L N   1 
ATOM   384  C  CA  . ASP A 1 51  ? -24.773 -8.377  9.519   1.00 26.23  ? 50  ASP L CA  1 
ATOM   385  C  C   . ASP A 1 51  ? -25.026 -8.163  11.024  1.00 25.95  ? 50  ASP L C   1 
ATOM   386  O  O   . ASP A 1 51  ? -25.876 -8.841  11.621  1.00 23.77  ? 50  ASP L O   1 
ATOM   387  C  CB  . ASP A 1 51  ? -25.377 -9.715  9.065   1.00 23.08  ? 50  ASP L CB  1 
ATOM   388  C  CG  . ASP A 1 51  ? -25.600 -9.783  7.551   1.00 36.60  ? 50  ASP L CG  1 
ATOM   389  O  OD1 . ASP A 1 51  ? -26.071 -10.838 7.071   1.00 31.36  ? 50  ASP L OD1 1 
ATOM   390  O  OD2 . ASP A 1 51  ? -25.326 -8.785  6.845   1.00 26.38  ? 50  ASP L OD2 1 
ATOM   391  N  N   . ALA A 1 52  ? -24.262 -7.247  11.625  1.00 18.70  ? 51  ALA L N   1 
ATOM   392  C  CA  . ALA A 1 52  ? -24.360 -6.881  13.054  1.00 16.82  ? 51  ALA L CA  1 
ATOM   393  C  C   . ALA A 1 52  ? -23.821 -7.916  14.046  1.00 20.95  ? 51  ALA L C   1 
ATOM   394  O  O   . ALA A 1 52  ? -23.160 -7.543  15.031  1.00 21.19  ? 51  ALA L O   1 
ATOM   395  C  CB  . ALA A 1 52  ? -25.793 -6.456  13.443  1.00 19.70  ? 51  ALA L CB  1 
ATOM   396  N  N   . SER A 1 53  ? -24.077 -9.197  13.784  1.00 16.92  ? 52  SER L N   1 
ATOM   397  C  CA  . SER A 1 53  ? -23.788 -10.253 14.762  1.00 19.51  ? 52  SER L CA  1 
ATOM   398  C  C   . SER A 1 53  ? -23.288 -11.595 14.216  1.00 22.58  ? 52  SER L C   1 
ATOM   399  O  O   . SER A 1 53  ? -23.015 -12.497 15.000  1.00 22.94  ? 52  SER L O   1 
ATOM   400  C  CB  . SER A 1 53  ? -25.027 -10.516 15.629  1.00 23.76  ? 52  SER L CB  1 
ATOM   401  O  OG  . SER A 1 53  ? -26.105 -10.973 14.834  1.00 25.61  ? 52  SER L OG  1 
ATOM   402  N  N   . LYS A 1 54  ? -23.161 -11.742 12.898  1.00 21.63  ? 53  LYS L N   1 
ATOM   403  C  CA  . LYS A 1 54  ? -22.658 -12.997 12.334  1.00 25.71  ? 53  LYS L CA  1 
ATOM   404  C  C   . LYS A 1 54  ? -21.129 -13.043 12.297  1.00 25.79  ? 53  LYS L C   1 
ATOM   405  O  O   . LYS A 1 54  ? -20.481 -12.072 11.887  1.00 21.45  ? 53  LYS L O   1 
ATOM   406  C  CB  . LYS A 1 54  ? -23.240 -13.246 10.937  1.00 26.17  ? 53  LYS L CB  1 
ATOM   407  C  CG  . LYS A 1 54  ? -24.746 -13.447 10.940  1.00 33.33  ? 53  LYS L CG  1 
ATOM   408  C  CD  . LYS A 1 54  ? -25.346 -13.390 9.539   1.00 38.04  ? 53  LYS L CD  1 
ATOM   409  C  CE  . LYS A 1 54  ? -26.879 -13.386 9.611   1.00 42.02  ? 53  LYS L CE  1 
ATOM   410  N  NZ  . LYS A 1 54  ? -27.504 -12.578 8.534   1.00 37.74  ? 53  LYS L NZ  1 
ATOM   411  N  N   . LEU A 1 55  ? -20.572 -14.170 12.737  1.00 20.60  ? 54  LEU L N   1 
ATOM   412  C  CA  . LEU A 1 55  ? -19.131 -14.372 12.821  1.00 22.59  ? 54  LEU L CA  1 
ATOM   413  C  C   . LEU A 1 55  ? -18.581 -14.759 11.461  1.00 29.48  ? 54  LEU L C   1 
ATOM   414  O  O   . LEU A 1 55  ? -19.079 -15.698 10.848  1.00 33.31  ? 54  LEU L O   1 
ATOM   415  C  CB  . LEU A 1 55  ? -18.818 -15.508 13.796  1.00 31.97  ? 54  LEU L CB  1 
ATOM   416  C  CG  . LEU A 1 55  ? -18.067 -15.328 15.121  1.00 39.43  ? 54  LEU L CG  1 
ATOM   417  C  CD1 . LEU A 1 55  ? -17.476 -16.676 15.555  1.00 32.26  ? 54  LEU L CD1 1 
ATOM   418  C  CD2 . LEU A 1 55  ? -16.991 -14.265 15.065  1.00 29.36  ? 54  LEU L CD2 1 
ATOM   419  N  N   . ALA A 1 56  ? -17.553 -14.060 10.985  1.00 29.62  ? 55  ALA L N   1 
ATOM   420  C  CA  . ALA A 1 56  ? -16.919 -14.440 9.728   1.00 31.68  ? 55  ALA L CA  1 
ATOM   421  C  C   . ALA A 1 56  ? -16.250 -15.794 9.905   1.00 27.60  ? 55  ALA L C   1 
ATOM   422  O  O   . ALA A 1 56  ? -15.804 -16.139 10.993  1.00 26.64  ? 55  ALA L O   1 
ATOM   423  C  CB  . ALA A 1 56  ? -15.900 -13.391 9.295   1.00 32.72  ? 55  ALA L CB  1 
ATOM   424  N  N   . SER A 1 57  ? -16.189 -16.569 8.832   1.00 35.66  ? 56  SER L N   1 
ATOM   425  C  CA  . SER A 1 57  ? -15.619 -17.907 8.899   1.00 31.66  ? 56  SER L CA  1 
ATOM   426  C  C   . SER A 1 57  ? -14.167 -17.860 9.387   1.00 30.61  ? 56  SER L C   1 
ATOM   427  O  O   . SER A 1 57  ? -13.366 -17.081 8.884   1.00 32.24  ? 56  SER L O   1 
ATOM   428  C  CB  . SER A 1 57  ? -15.727 -18.578 7.525   1.00 42.47  ? 56  SER L CB  1 
ATOM   429  O  OG  . SER A 1 57  ? -15.293 -19.925 7.572   1.00 46.54  ? 56  SER L OG  1 
ATOM   430  N  N   . GLY A 1 58  ? -13.841 -18.664 10.400  1.00 28.00  ? 57  GLY L N   1 
ATOM   431  C  CA  . GLY A 1 58  ? -12.473 -18.729 10.900  1.00 31.57  ? 57  GLY L CA  1 
ATOM   432  C  C   . GLY A 1 58  ? -12.115 -17.719 11.976  1.00 35.63  ? 57  GLY L C   1 
ATOM   433  O  O   . GLY A 1 58  ? -10.963 -17.655 12.416  1.00 40.40  ? 57  GLY L O   1 
ATOM   434  N  N   . VAL A 1 59  ? -13.089 -16.911 12.388  1.00 30.46  ? 58  VAL L N   1 
ATOM   435  C  CA  . VAL A 1 59  ? -12.872 -15.927 13.446  1.00 27.28  ? 58  VAL L CA  1 
ATOM   436  C  C   . VAL A 1 59  ? -13.268 -16.546 14.797  1.00 26.06  ? 58  VAL L C   1 
ATOM   437  O  O   . VAL A 1 59  ? -14.316 -17.177 14.895  1.00 26.40  ? 58  VAL L O   1 
ATOM   438  C  CB  . VAL A 1 59  ? -13.698 -14.653 13.162  1.00 27.86  ? 58  VAL L CB  1 
ATOM   439  C  CG1 . VAL A 1 59  ? -13.596 -13.653 14.308  1.00 28.98  ? 58  VAL L CG1 1 
ATOM   440  C  CG2 . VAL A 1 59  ? -13.238 -14.017 11.853  1.00 27.55  ? 58  VAL L CG2 1 
ATOM   441  N  N   . PRO A 1 60  ? -12.421 -16.386 15.832  1.00 27.69  ? 59  PRO L N   1 
ATOM   442  C  CA  . PRO A 1 60  ? -12.673 -16.918 17.185  1.00 33.32  ? 59  PRO L CA  1 
ATOM   443  C  C   . PRO A 1 60  ? -14.000 -16.433 17.780  1.00 35.51  ? 59  PRO L C   1 
ATOM   444  O  O   . PRO A 1 60  ? -14.357 -15.272 17.592  1.00 26.92  ? 59  PRO L O   1 
ATOM   445  C  CB  . PRO A 1 60  ? -11.511 -16.345 18.008  1.00 31.43  ? 59  PRO L CB  1 
ATOM   446  C  CG  . PRO A 1 60  ? -10.432 -16.096 17.020  1.00 38.62  ? 59  PRO L CG  1 
ATOM   447  C  CD  . PRO A 1 60  ? -11.123 -15.692 15.746  1.00 33.17  ? 59  PRO L CD  1 
ATOM   448  N  N   . SER A 1 61  ? -14.703 -17.298 18.506  1.00 28.19  ? 60  SER L N   1 
ATOM   449  C  CA  . SER A 1 61  ? -16.029 -16.969 19.040  1.00 32.40  ? 60  SER L CA  1 
ATOM   450  C  C   . SER A 1 61  ? -15.985 -16.062 20.271  1.00 25.89  ? 60  SER L C   1 
ATOM   451  O  O   . SER A 1 61  ? -17.029 -15.696 20.817  1.00 31.80  ? 60  SER L O   1 
ATOM   452  C  CB  . SER A 1 61  ? -16.792 -18.241 19.395  1.00 32.75  ? 60  SER L CB  1 
ATOM   453  O  OG  . SER A 1 61  ? -16.076 -18.978 20.378  1.00 38.79  ? 60  SER L OG  1 
ATOM   454  N  N   . ARG A 1 62  ? -14.793 -15.704 20.719  1.00 22.74  ? 61  ARG L N   1 
ATOM   455  C  CA  . ARG A 1 62  ? -14.699 -14.720 21.787  1.00 28.83  ? 61  ARG L CA  1 
ATOM   456  C  C   . ARG A 1 62  ? -14.936 -13.309 21.238  1.00 25.01  ? 61  ARG L C   1 
ATOM   457  O  O   . ARG A 1 62  ? -15.012 -12.336 22.001  1.00 23.27  ? 61  ARG L O   1 
ATOM   458  C  CB  . ARG A 1 62  ? -13.368 -14.833 22.525  1.00 31.27  ? 61  ARG L CB  1 
ATOM   459  C  CG  . ARG A 1 62  ? -12.173 -14.809 21.623  1.00 36.00  ? 61  ARG L CG  1 
ATOM   460  C  CD  . ARG A 1 62  ? -10.918 -15.339 22.316  1.00 36.48  ? 61  ARG L CD  1 
ATOM   461  N  NE  . ARG A 1 62  ? -9.780  -15.075 21.451  1.00 35.48  ? 61  ARG L NE  1 
ATOM   462  C  CZ  . ARG A 1 62  ? -9.185  -13.891 21.380  1.00 31.16  ? 61  ARG L CZ  1 
ATOM   463  N  NH1 . ARG A 1 62  ? -8.172  -13.699 20.545  1.00 24.77  ? 61  ARG L NH1 1 
ATOM   464  N  NH2 . ARG A 1 62  ? -9.619  -12.901 22.144  1.00 18.83  ? 61  ARG L NH2 1 
ATOM   465  N  N   . PHE A 1 63  ? -15.087 -13.211 19.915  1.00 20.52  ? 62  PHE L N   1 
ATOM   466  C  CA  . PHE A 1 63  ? -15.512 -11.962 19.279  1.00 24.44  ? 62  PHE L CA  1 
ATOM   467  C  C   . PHE A 1 63  ? -17.011 -11.977 19.087  1.00 26.13  ? 62  PHE L C   1 
ATOM   468  O  O   . PHE A 1 63  ? -17.559 -12.923 18.542  1.00 24.28  ? 62  PHE L O   1 
ATOM   469  C  CB  . PHE A 1 63  ? -14.855 -11.762 17.914  1.00 28.14  ? 62  PHE L CB  1 
ATOM   470  C  CG  . PHE A 1 63  ? -13.383 -11.513 17.976  1.00 25.84  ? 62  PHE L CG  1 
ATOM   471  C  CD1 . PHE A 1 63  ? -12.882 -10.384 18.596  1.00 26.45  ? 62  PHE L CD1 1 
ATOM   472  C  CD2 . PHE A 1 63  ? -12.498 -12.385 17.376  1.00 35.57  ? 62  PHE L CD2 1 
ATOM   473  C  CE1 . PHE A 1 63  ? -11.517 -10.149 18.643  1.00 33.25  ? 62  PHE L CE1 1 
ATOM   474  C  CE2 . PHE A 1 63  ? -11.135 -12.149 17.416  1.00 36.20  ? 62  PHE L CE2 1 
ATOM   475  C  CZ  . PHE A 1 63  ? -10.644 -11.029 18.049  1.00 24.12  ? 62  PHE L CZ  1 
ATOM   476  N  N   . LYS A 1 64  ? -17.679 -10.913 19.515  1.00 21.83  ? 63  LYS L N   1 
ATOM   477  C  CA  . LYS A 1 64  ? -19.132 -10.891 19.471  1.00 20.91  ? 63  LYS L CA  1 
ATOM   478  C  C   . LYS A 1 64  ? -19.664 -9.488  19.150  1.00 23.78  ? 63  LYS L C   1 
ATOM   479  O  O   . LYS A 1 64  ? -19.170 -8.494  19.678  1.00 22.26  ? 63  LYS L O   1 
ATOM   480  C  CB  . LYS A 1 64  ? -19.677 -11.431 20.801  1.00 23.52  ? 63  LYS L CB  1 
ATOM   481  C  CG  . LYS A 1 64  ? -21.108 -11.045 21.117  1.00 38.59  ? 63  LYS L CG  1 
ATOM   482  C  CD  . LYS A 1 64  ? -21.585 -11.689 22.428  1.00 50.36  ? 63  LYS L CD  1 
ATOM   483  C  CE  . LYS A 1 64  ? -20.589 -11.476 23.585  1.00 62.08  ? 63  LYS L CE  1 
ATOM   484  N  NZ  . LYS A 1 64  ? -20.855 -10.269 24.456  1.00 54.13  ? 63  LYS L NZ  1 
ATOM   485  N  N   . GLY A 1 65  ? -20.648 -9.409  18.254  1.00 20.39  ? 64  GLY L N   1 
ATOM   486  C  CA  . GLY A 1 65  ? -21.291 -8.140  17.952  1.00 22.48  ? 64  GLY L CA  1 
ATOM   487  C  C   . GLY A 1 65  ? -22.786 -8.210  18.244  1.00 30.28  ? 64  GLY L C   1 
ATOM   488  O  O   . GLY A 1 65  ? -23.389 -9.277  18.191  1.00 25.04  ? 64  GLY L O   1 
ATOM   489  N  N   . SER A 1 66  ? -23.389 -7.081  18.583  1.00 22.69  ? 65  SER L N   1 
ATOM   490  C  CA  . SER A 1 66  ? -24.842 -7.018  18.692  1.00 23.85  ? 65  SER L CA  1 
ATOM   491  C  C   . SER A 1 66  ? -25.339 -5.612  18.418  1.00 26.40  ? 65  SER L C   1 
ATOM   492  O  O   . SER A 1 66  ? -24.540 -4.673  18.320  1.00 26.64  ? 65  SER L O   1 
ATOM   493  C  CB  . SER A 1 66  ? -25.314 -7.503  20.064  1.00 35.56  ? 65  SER L CB  1 
ATOM   494  O  OG  . SER A 1 66  ? -24.933 -6.600  21.064  1.00 36.85  ? 65  SER L OG  1 
ATOM   495  N  N   . GLY A 1 67  ? -26.655 -5.472  18.272  1.00 25.30  ? 66  GLY L N   1 
ATOM   496  C  CA  . GLY A 1 67  ? -27.270 -4.174  18.059  1.00 24.67  ? 66  GLY L CA  1 
ATOM   497  C  C   . GLY A 1 67  ? -28.115 -4.163  16.800  1.00 27.37  ? 66  GLY L C   1 
ATOM   498  O  O   . GLY A 1 67  ? -28.175 -5.150  16.076  1.00 25.78  ? 66  GLY L O   1 
ATOM   499  N  N   . SER A 1 68  ? -28.745 -3.031  16.521  1.00 26.09  ? 67  SER L N   1 
ATOM   500  C  CA  . SER A 1 68  ? -29.673 -2.939  15.404  1.00 24.83  ? 67  SER L CA  1 
ATOM   501  C  C   . SER A 1 68  ? -30.039 -1.474  15.165  1.00 28.32  ? 67  SER L C   1 
ATOM   502  O  O   . SER A 1 68  ? -29.956 -0.652  16.074  1.00 29.58  ? 67  SER L O   1 
ATOM   503  C  CB  . SER A 1 68  ? -30.932 -3.757  15.739  1.00 41.96  ? 67  SER L CB  1 
ATOM   504  O  OG  . SER A 1 68  ? -31.913 -3.695  14.719  1.00 44.52  ? 67  SER L OG  1 
ATOM   505  N  N   . GLY A 1 69  ? -30.446 -1.134  13.951  1.00 24.70  ? 68  GLY L N   1 
ATOM   506  C  CA  . GLY A 1 69  ? -30.876 0.230   13.700  1.00 24.10  ? 68  GLY L CA  1 
ATOM   507  C  C   . GLY A 1 69  ? -29.717 1.207   13.658  1.00 26.44  ? 68  GLY L C   1 
ATOM   508  O  O   . GLY A 1 69  ? -28.984 1.255   12.667  1.00 24.55  ? 68  GLY L O   1 
ATOM   509  N  N   . THR A 1 70  ? -29.555 1.990   14.729  1.00 25.47  ? 69  THR L N   1 
ATOM   510  C  CA  . THR A 1 70  ? -28.495 2.983   14.798  1.00 21.88  ? 69  THR L CA  1 
ATOM   511  C  C   . THR A 1 70  ? -27.502 2.759   15.936  1.00 23.11  ? 69  THR L C   1 
ATOM   512  O  O   . THR A 1 70  ? -26.588 3.552   16.098  1.00 26.05  ? 69  THR L O   1 
ATOM   513  C  CB  . THR A 1 70  ? -29.057 4.423   15.001  1.00 24.79  ? 69  THR L CB  1 
ATOM   514  O  OG1 . THR A 1 70  ? -29.730 4.486   16.264  1.00 28.66  ? 69  THR L OG1 1 
ATOM   515  C  CG2 . THR A 1 70  ? -30.020 4.813   13.876  1.00 24.30  ? 69  THR L CG2 1 
ATOM   516  N  N   . GLN A 1 71  ? -27.691 1.717   16.732  1.00 20.08  ? 70  GLN L N   1 
ATOM   517  C  CA  . GLN A 1 71  ? -26.854 1.492   17.912  1.00 25.41  ? 70  GLN L CA  1 
ATOM   518  C  C   . GLN A 1 71  ? -26.252 0.091   17.927  1.00 22.11  ? 70  GLN L C   1 
ATOM   519  O  O   . GLN A 1 71  ? -26.984 -0.893  17.917  1.00 22.35  ? 70  GLN L O   1 
ATOM   520  C  CB  . GLN A 1 71  ? -27.686 1.722   19.183  1.00 29.55  ? 70  GLN L CB  1 
ATOM   521  C  CG  . GLN A 1 71  ? -28.275 3.141   19.246  1.00 39.25  ? 70  GLN L CG  1 
ATOM   522  C  CD  . GLN A 1 71  ? -29.472 3.275   20.180  1.00 62.69  ? 70  GLN L CD  1 
ATOM   523  O  OE1 . GLN A 1 71  ? -29.336 3.720   21.324  1.00 57.01  ? 70  GLN L OE1 1 
ATOM   524  N  NE2 . GLN A 1 71  ? -30.660 2.913   19.683  1.00 52.82  ? 70  GLN L NE2 1 
ATOM   525  N  N   . PHE A 1 72  ? -24.919 0.007   17.955  1.00 22.31  ? 71  PHE L N   1 
ATOM   526  C  CA  . PHE A 1 72  ? -24.215 -1.274  17.842  1.00 22.56  ? 71  PHE L CA  1 
ATOM   527  C  C   . PHE A 1 72  ? -23.043 -1.359  18.829  1.00 19.46  ? 71  PHE L C   1 
ATOM   528  O  O   . PHE A 1 72  ? -22.402 -0.357  19.119  1.00 20.53  ? 71  PHE L O   1 
ATOM   529  C  CB  . PHE A 1 72  ? -23.680 -1.456  16.411  1.00 21.83  ? 71  PHE L CB  1 
ATOM   530  C  CG  . PHE A 1 72  ? -24.735 -1.359  15.358  1.00 21.96  ? 71  PHE L CG  1 
ATOM   531  C  CD1 . PHE A 1 72  ? -25.073 -0.135  14.810  1.00 20.84  ? 71  PHE L CD1 1 
ATOM   532  C  CD2 . PHE A 1 72  ? -25.393 -2.493  14.914  1.00 19.98  ? 71  PHE L CD2 1 
ATOM   533  C  CE1 . PHE A 1 72  ? -26.061 -0.033  13.839  1.00 25.37  ? 71  PHE L CE1 1 
ATOM   534  C  CE2 . PHE A 1 72  ? -26.385 -2.398  13.940  1.00 23.24  ? 71  PHE L CE2 1 
ATOM   535  C  CZ  . PHE A 1 72  ? -26.717 -1.158  13.411  1.00 18.27  ? 71  PHE L CZ  1 
ATOM   536  N  N   . THR A 1 73  ? -22.776 -2.554  19.349  1.00 18.38  ? 72  THR L N   1 
ATOM   537  C  CA  . THR A 1 73  ? -21.614 -2.748  20.219  1.00 23.79  ? 72  THR L CA  1 
ATOM   538  C  C   . THR A 1 73  ? -20.818 -3.963  19.781  1.00 22.81  ? 72  THR L C   1 
ATOM   539  O  O   . THR A 1 73  ? -21.356 -4.866  19.141  1.00 24.65  ? 72  THR L O   1 
ATOM   540  C  CB  . THR A 1 73  ? -22.023 -2.961  21.690  1.00 27.09  ? 72  THR L CB  1 
ATOM   541  O  OG1 . THR A 1 73  ? -22.781 -4.170  21.788  1.00 26.69  ? 72  THR L OG1 1 
ATOM   542  C  CG2 . THR A 1 73  ? -22.852 -1.785  22.204  1.00 25.36  ? 72  THR L CG2 1 
ATOM   543  N  N   . PHE A 1 74  ? -19.538 -3.986  20.148  1.00 21.59  ? 73  PHE L N   1 
ATOM   544  C  CA  . PHE A 1 74  ? -18.630 -5.064  19.785  1.00 19.65  ? 73  PHE L CA  1 
ATOM   545  C  C   . PHE A 1 74  ? -17.821 -5.428  21.036  1.00 25.09  ? 73  PHE L C   1 
ATOM   546  O  O   . PHE A 1 74  ? -17.280 -4.548  21.705  1.00 21.36  ? 73  PHE L O   1 
ATOM   547  C  CB  . PHE A 1 74  ? -17.720 -4.616  18.636  1.00 17.08  ? 73  PHE L CB  1 
ATOM   548  C  CG  . PHE A 1 74  ? -16.535 -5.527  18.380  1.00 18.89  ? 73  PHE L CG  1 
ATOM   549  C  CD1 . PHE A 1 74  ? -16.671 -6.670  17.608  1.00 17.01  ? 73  PHE L CD1 1 
ATOM   550  C  CD2 . PHE A 1 74  ? -15.269 -5.208  18.881  1.00 20.12  ? 73  PHE L CD2 1 
ATOM   551  C  CE1 . PHE A 1 74  ? -15.571 -7.496  17.355  1.00 20.22  ? 73  PHE L CE1 1 
ATOM   552  C  CE2 . PHE A 1 74  ? -14.180 -6.024  18.638  1.00 18.24  ? 73  PHE L CE2 1 
ATOM   553  C  CZ  . PHE A 1 74  ? -14.325 -7.169  17.877  1.00 14.05  ? 73  PHE L CZ  1 
ATOM   554  N  N   . THR A 1 75  ? -17.775 -6.714  21.378  1.00 18.73  ? 74  THR L N   1 
ATOM   555  C  CA  . THR A 1 75  ? -17.129 -7.125  22.630  1.00 18.08  ? 74  THR L CA  1 
ATOM   556  C  C   . THR A 1 75  ? -16.136 -8.250  22.372  1.00 21.37  ? 74  THR L C   1 
ATOM   557  O  O   . THR A 1 75  ? -16.469 -9.246  21.722  1.00 19.41  ? 74  THR L O   1 
ATOM   558  C  CB  . THR A 1 75  ? -18.169 -7.569  23.706  1.00 21.40  ? 74  THR L CB  1 
ATOM   559  O  OG1 . THR A 1 75  ? -18.946 -6.439  24.141  1.00 18.21  ? 74  THR L OG1 1 
ATOM   560  C  CG2 . THR A 1 75  ? -17.477 -8.192  24.931  1.00 15.62  ? 74  THR L CG2 1 
ATOM   561  N  N   . ILE A 1 76  ? -14.920 -8.079  22.879  1.00 18.48  ? 75  ILE L N   1 
ATOM   562  C  CA  . ILE A 1 76  ? -13.929 -9.147  22.878  1.00 18.83  ? 75  ILE L CA  1 
ATOM   563  C  C   . ILE A 1 76  ? -13.889 -9.765  24.271  1.00 21.31  ? 75  ILE L C   1 
ATOM   564  O  O   . ILE A 1 76  ? -13.634 -9.062  25.247  1.00 17.25  ? 75  ILE L O   1 
ATOM   565  C  CB  . ILE A 1 76  ? -12.515 -8.603  22.579  1.00 19.46  ? 75  ILE L CB  1 
ATOM   566  C  CG1 . ILE A 1 76  ? -12.485 -7.870  21.248  1.00 24.92  ? 75  ILE L CG1 1 
ATOM   567  C  CG2 . ILE A 1 76  ? -11.488 -9.731  22.570  1.00 20.49  ? 75  ILE L CG2 1 
ATOM   568  C  CD1 . ILE A 1 76  ? -11.094 -7.273  20.936  1.00 25.50  ? 75  ILE L CD1 1 
ATOM   569  N  N   . SER A 1 77  ? -14.162 -11.067 24.357  1.00 19.49  ? 76  SER L N   1 
ATOM   570  C  CA  . SER A 1 77  ? -13.994 -11.837 25.596  1.00 23.62  ? 76  SER L CA  1 
ATOM   571  C  C   . SER A 1 77  ? -12.590 -12.428 25.721  1.00 27.46  ? 76  SER L C   1 
ATOM   572  O  O   . SER A 1 77  ? -11.953 -12.759 24.718  1.00 25.71  ? 76  SER L O   1 
ATOM   573  C  CB  . SER A 1 77  ? -14.998 -12.993 25.639  1.00 23.40  ? 76  SER L CB  1 
ATOM   574  O  OG  . SER A 1 77  ? -16.291 -12.493 25.853  1.00 27.84  ? 76  SER L OG  1 
ATOM   575  N  N   . ASP A 1 78  ? -12.136 -12.591 26.959  1.00 25.26  ? 77  ASP L N   1 
ATOM   576  C  CA  . ASP A 1 78  ? -10.839 -13.189 27.244  1.00 25.58  ? 77  ASP L CA  1 
ATOM   577  C  C   . ASP A 1 78  ? -9.731  -12.593 26.355  1.00 20.21  ? 77  ASP L C   1 
ATOM   578  O  O   . ASP A 1 78  ? -9.119  -13.293 25.553  1.00 16.55  ? 77  ASP L O   1 
ATOM   579  C  CB  . ASP A 1 78  ? -10.923 -14.709 27.071  1.00 26.37  ? 77  ASP L CB  1 
ATOM   580  C  CG  . ASP A 1 78  ? -9.721  -15.428 27.642  1.00 34.43  ? 77  ASP L CG  1 
ATOM   581  O  OD1 . ASP A 1 78  ? -9.547  -16.625 27.338  1.00 40.39  ? 77  ASP L OD1 1 
ATOM   582  O  OD2 . ASP A 1 78  ? -8.946  -14.800 28.393  1.00 35.59  ? 77  ASP L OD2 1 
ATOM   583  N  N   . VAL A 1 79  ? -9.507  -11.295 26.501  1.00 19.39  ? 78  VAL L N   1 
ATOM   584  C  CA  . VAL A 1 79  ? -8.584  -10.539 25.666  1.00 16.68  ? 78  VAL L CA  1 
ATOM   585  C  C   . VAL A 1 79  ? -7.179  -11.118 25.710  1.00 17.34  ? 78  VAL L C   1 
ATOM   586  O  O   . VAL A 1 79  ? -6.670  -11.481 26.777  1.00 20.97  ? 78  VAL L O   1 
ATOM   587  C  CB  . VAL A 1 79  ? -8.527  -9.039  26.123  1.00 18.76  ? 78  VAL L CB  1 
ATOM   588  C  CG1 . VAL A 1 79  ? -7.349  -8.302  25.457  1.00 15.65  ? 78  VAL L CG1 1 
ATOM   589  C  CG2 . VAL A 1 79  ? -9.842  -8.363  25.867  1.00 15.23  ? 78  VAL L CG2 1 
ATOM   590  N  N   . GLN A 1 80  ? -6.551  -11.212 24.547  1.00 19.58  ? 79  GLN L N   1 
ATOM   591  C  CA  . GLN A 1 80  ? -5.194  -11.763 24.445  1.00 18.23  ? 79  GLN L CA  1 
ATOM   592  C  C   . GLN A 1 80  ? -4.243  -10.720 23.875  1.00 23.86  ? 79  GLN L C   1 
ATOM   593  O  O   . GLN A 1 80  ? -4.675  -9.770  23.219  1.00 20.46  ? 79  GLN L O   1 
ATOM   594  C  CB  . GLN A 1 80  ? -5.183  -13.009 23.528  1.00 21.79  ? 79  GLN L CB  1 
ATOM   595  C  CG  . GLN A 1 80  ? -5.982  -14.199 24.056  1.00 28.05  ? 79  GLN L CG  1 
ATOM   596  C  CD  . GLN A 1 80  ? -5.592  -14.581 25.473  1.00 32.66  ? 79  GLN L CD  1 
ATOM   597  O  OE1 . GLN A 1 80  ? -4.425  -14.866 25.746  1.00 43.35  ? 79  GLN L OE1 1 
ATOM   598  N  NE2 . GLN A 1 80  ? -6.563  -14.563 26.397  1.00 35.39  ? 79  GLN L NE2 1 
ATOM   599  N  N   . CYS A 1 81  ? -2.939  -10.902 24.101  1.00 21.49  ? 80  CYS L N   1 
ATOM   600  C  CA  . CYS A 1 81  ? -1.951  -9.993  23.520  1.00 19.58  ? 80  CYS L CA  1 
ATOM   601  C  C   . CYS A 1 81  ? -2.103  -9.889  21.995  1.00 21.73  ? 80  CYS L C   1 
ATOM   602  O  O   . CYS A 1 81  ? -1.905  -8.815  21.415  1.00 18.61  ? 80  CYS L O   1 
ATOM   603  C  CB  . CYS A 1 81  ? -0.530  -10.423 23.890  1.00 19.88  ? 80  CYS L CB  1 
ATOM   604  S  SG  . CYS A 1 81  ? -0.195  -10.273 25.636  1.00 22.91  ? 80  CYS L SG  1 
ATOM   605  N  N   . ASP A 1 82  ? -2.492  -10.992 21.358  1.00 20.93  ? 81  ASP L N   1 
ATOM   606  C  CA  . ASP A 1 82  ? -2.689  -11.023 19.903  1.00 21.57  ? 81  ASP L CA  1 
ATOM   607  C  C   . ASP A 1 82  ? -3.797  -10.086 19.429  1.00 24.81  ? 81  ASP L C   1 
ATOM   608  O  O   . ASP A 1 82  ? -3.866  -9.767  18.237  1.00 23.45  ? 81  ASP L O   1 
ATOM   609  C  CB  . ASP A 1 82  ? -2.959  -12.463 19.422  1.00 28.19  ? 81  ASP L CB  1 
ATOM   610  C  CG  . ASP A 1 82  ? -2.894  -12.604 17.896  1.00 36.95  ? 81  ASP L CG  1 
ATOM   611  O  OD1 . ASP A 1 82  ? -3.879  -13.096 17.297  1.00 39.65  ? 81  ASP L OD1 1 
ATOM   612  O  OD2 . ASP A 1 82  ? -1.864  -12.216 17.298  1.00 26.35  ? 81  ASP L OD2 1 
ATOM   613  N  N   . ASP A 1 83  ? -4.650  -9.628  20.348  1.00 21.03  ? 82  ASP L N   1 
ATOM   614  C  CA  . ASP A 1 83  ? -5.798  -8.788  19.980  1.00 22.17  ? 82  ASP L CA  1 
ATOM   615  C  C   . ASP A 1 83  ? -5.435  -7.308  19.839  1.00 21.76  ? 82  ASP L C   1 
ATOM   616  O  O   . ASP A 1 83  ? -6.194  -6.531  19.273  1.00 22.47  ? 82  ASP L O   1 
ATOM   617  C  CB  . ASP A 1 83  ? -6.941  -8.914  21.002  1.00 19.37  ? 82  ASP L CB  1 
ATOM   618  C  CG  . ASP A 1 83  ? -7.488  -10.339 21.118  1.00 23.65  ? 82  ASP L CG  1 
ATOM   619  O  OD1 . ASP A 1 83  ? -7.410  -11.111 20.144  1.00 24.21  ? 82  ASP L OD1 1 
ATOM   620  O  OD2 . ASP A 1 83  ? -7.995  -10.674 22.209  1.00 22.62  ? 82  ASP L OD2 1 
ATOM   621  N  N   . ALA A 1 84  ? -4.293  -6.917  20.395  1.00 16.83  ? 83  ALA L N   1 
ATOM   622  C  CA  . ALA A 1 84  ? -3.849  -5.535  20.357  1.00 21.80  ? 83  ALA L CA  1 
ATOM   623  C  C   . ALA A 1 84  ? -3.794  -5.022  18.928  1.00 24.09  ? 83  ALA L C   1 
ATOM   624  O  O   . ALA A 1 84  ? -2.974  -5.473  18.131  1.00 22.75  ? 83  ALA L O   1 
ATOM   625  C  CB  . ALA A 1 84  ? -2.471  -5.390  21.040  1.00 19.65  ? 83  ALA L CB  1 
ATOM   626  N  N   . ALA A 1 85  ? -4.686  -4.088  18.612  1.00 22.91  ? 84  ALA L N   1 
ATOM   627  C  CA  . ALA A 1 85  ? -4.856  -3.591  17.251  1.00 23.13  ? 84  ALA L CA  1 
ATOM   628  C  C   . ALA A 1 85  ? -5.777  -2.382  17.254  1.00 21.15  ? 84  ALA L C   1 
ATOM   629  O  O   . ALA A 1 85  ? -6.206  -1.926  18.314  1.00 17.04  ? 84  ALA L O   1 
ATOM   630  C  CB  . ALA A 1 85  ? -5.434  -4.685  16.361  1.00 16.17  ? 84  ALA L CB  1 
ATOM   631  N  N   . THR A 1 86  ? -6.068  -1.860  16.065  1.00 16.55  ? 85  THR L N   1 
ATOM   632  C  CA  . THR A 1 86  ? -7.146  -0.890  15.897  1.00 16.79  ? 85  THR L CA  1 
ATOM   633  C  C   . THR A 1 86  ? -8.349  -1.574  15.260  1.00 16.43  ? 85  THR L C   1 
ATOM   634  O  O   . THR A 1 86  ? -8.200  -2.308  14.274  1.00 18.63  ? 85  THR L O   1 
ATOM   635  C  CB  . THR A 1 86  ? -6.697  0.286   15.001  1.00 19.96  ? 85  THR L CB  1 
ATOM   636  O  OG1 . THR A 1 86  ? -5.513  0.865   15.548  1.00 22.06  ? 85  THR L OG1 1 
ATOM   637  C  CG2 . THR A 1 86  ? -7.775  1.362   14.916  1.00 20.33  ? 85  THR L CG2 1 
ATOM   638  N  N   . PHE A 1 87  ? -9.532  -1.328  15.819  1.00 15.00  ? 86  PHE L N   1 
ATOM   639  C  CA  . PHE A 1 87  ? -10.782 -1.925  15.336  1.00 17.47  ? 86  PHE L CA  1 
ATOM   640  C  C   . PHE A 1 87  ? -11.700 -0.849  14.751  1.00 15.14  ? 86  PHE L C   1 
ATOM   641  O  O   . PHE A 1 87  ? -11.753 0.282   15.254  1.00 15.63  ? 86  PHE L O   1 
ATOM   642  C  CB  . PHE A 1 87  ? -11.506 -2.646  16.481  1.00 16.70  ? 86  PHE L CB  1 
ATOM   643  C  CG  . PHE A 1 87  ? -10.733 -3.820  17.047  1.00 16.44  ? 86  PHE L CG  1 
ATOM   644  C  CD1 . PHE A 1 87  ? -9.699  -3.622  17.952  1.00 15.12  ? 86  PHE L CD1 1 
ATOM   645  C  CD2 . PHE A 1 87  ? -11.026 -5.111  16.647  1.00 17.39  ? 86  PHE L CD2 1 
ATOM   646  C  CE1 . PHE A 1 87  ? -8.991  -4.689  18.466  1.00 15.80  ? 86  PHE L CE1 1 
ATOM   647  C  CE2 . PHE A 1 87  ? -10.325 -6.189  17.155  1.00 15.57  ? 86  PHE L CE2 1 
ATOM   648  C  CZ  . PHE A 1 87  ? -9.296  -5.975  18.068  1.00 15.30  ? 86  PHE L CZ  1 
ATOM   649  N  N   . TYR A 1 88  ? -12.425 -1.209  13.699  1.00 16.15  ? 87  TYR L N   1 
ATOM   650  C  CA  . TYR A 1 88  ? -13.323 -0.275  13.012  1.00 16.48  ? 87  TYR L CA  1 
ATOM   651  C  C   . TYR A 1 88  ? -14.700 -0.886  12.793  1.00 18.06  ? 87  TYR L C   1 
ATOM   652  O  O   . TYR A 1 88  ? -14.812 -2.088  12.476  1.00 18.17  ? 87  TYR L O   1 
ATOM   653  C  CB  . TYR A 1 88  ? -12.780 0.070   11.622  1.00 19.29  ? 87  TYR L CB  1 
ATOM   654  C  CG  . TYR A 1 88  ? -11.476 0.828   11.600  1.00 15.96  ? 87  TYR L CG  1 
ATOM   655  C  CD1 . TYR A 1 88  ? -11.466 2.219   11.617  1.00 15.10  ? 87  TYR L CD1 1 
ATOM   656  C  CD2 . TYR A 1 88  ? -10.261 0.161   11.551  1.00 18.36  ? 87  TYR L CD2 1 
ATOM   657  C  CE1 . TYR A 1 88  ? -10.276 2.929   11.592  1.00 17.07  ? 87  TYR L CE1 1 
ATOM   658  C  CE2 . TYR A 1 88  ? -9.052  0.869   11.527  1.00 20.06  ? 87  TYR L CE2 1 
ATOM   659  C  CZ  . TYR A 1 88  ? -9.077  2.248   11.549  1.00 20.03  ? 87  TYR L CZ  1 
ATOM   660  O  OH  . TYR A 1 88  ? -7.906  2.964   11.540  1.00 19.04  ? 87  TYR L OH  1 
ATOM   661  N  N   . CYS A 1 89  ? -15.739 -0.058  12.908  1.00 17.10  ? 88  CYS L N   1 
ATOM   662  C  CA  . CYS A 1 89  ? -17.071 -0.443  12.439  1.00 16.13  ? 88  CYS L CA  1 
ATOM   663  C  C   . CYS A 1 89  ? -17.315 0.148   11.040  1.00 16.37  ? 88  CYS L C   1 
ATOM   664  O  O   . CYS A 1 89  ? -16.765 1.212   10.696  1.00 14.96  ? 88  CYS L O   1 
ATOM   665  C  CB  . CYS A 1 89  ? -18.166 -0.018  13.435  1.00 14.49  ? 88  CYS L CB  1 
ATOM   666  S  SG  . CYS A 1 89  ? -18.327 1.788   13.660  1.00 18.79  ? 88  CYS L SG  1 
ATOM   667  N  N   . LEU A 1 90  ? -18.096 -0.557  10.220  1.00 15.72  ? 89  LEU L N   1 
ATOM   668  C  CA  . LEU A 1 90  ? -18.475 -0.054  8.892   1.00 17.93  ? 89  LEU L CA  1 
ATOM   669  C  C   . LEU A 1 90  ? -19.971 -0.208  8.665   1.00 17.46  ? 89  LEU L C   1 
ATOM   670  O  O   . LEU A 1 90  ? -20.504 -1.314  8.785   1.00 19.97  ? 89  LEU L O   1 
ATOM   671  C  CB  . LEU A 1 90  ? -17.724 -0.815  7.787   1.00 14.91  ? 89  LEU L CB  1 
ATOM   672  C  CG  . LEU A 1 90  ? -18.227 -0.656  6.335   1.00 17.43  ? 89  LEU L CG  1 
ATOM   673  C  CD1 . LEU A 1 90  ? -17.906 0.723   5.781   1.00 15.15  ? 89  LEU L CD1 1 
ATOM   674  C  CD2 . LEU A 1 90  ? -17.615 -1.751  5.417   1.00 14.92  ? 89  LEU L CD2 1 
ATOM   675  N  N   . GLY A 1 91  ? -20.642 0.888   8.322   1.00 15.75  ? 90  GLY L N   1 
ATOM   676  C  CA  . GLY A 1 91  ? -22.064 0.851   8.019   1.00 14.18  ? 90  GLY L CA  1 
ATOM   677  C  C   . GLY A 1 91  ? -22.355 0.862   6.522   1.00 20.98  ? 90  GLY L C   1 
ATOM   678  O  O   . GLY A 1 91  ? -21.696 1.579   5.761   1.00 19.66  ? 90  GLY L O   1 
ATOM   679  N  N   . GLY A 1 92  ? -23.324 0.047   6.107   1.00 19.52  ? 91  GLY L N   1 
ATOM   680  C  CA  . GLY A 1 92  ? -23.879 0.088   4.762   1.00 21.63  ? 91  GLY L CA  1 
ATOM   681  C  C   . GLY A 1 92  ? -25.254 0.736   4.833   1.00 22.86  ? 91  GLY L C   1 
ATOM   682  O  O   . GLY A 1 92  ? -26.032 0.406   5.725   1.00 22.31  ? 91  GLY L O   1 
ATOM   683  N  N   . TYR A 1 93  ? -25.549 1.649   3.903   1.00 19.48  ? 92  TYR L N   1 
ATOM   684  C  CA  . TYR A 1 93  ? -26.742 2.500   3.977   1.00 18.91  ? 92  TYR L CA  1 
ATOM   685  C  C   . TYR A 1 93  ? -27.618 2.427   2.726   1.00 22.25  ? 92  TYR L C   1 
ATOM   686  O  O   . TYR A 1 93  ? -27.215 1.873   1.712   1.00 19.97  ? 92  TYR L O   1 
ATOM   687  C  CB  . TYR A 1 93  ? -26.332 3.956   4.247   1.00 18.71  ? 92  TYR L CB  1 
ATOM   688  C  CG  . TYR A 1 93  ? -25.665 4.111   5.587   1.00 21.97  ? 92  TYR L CG  1 
ATOM   689  C  CD1 . TYR A 1 93  ? -26.424 4.319   6.731   1.00 24.17  ? 92  TYR L CD1 1 
ATOM   690  C  CD2 . TYR A 1 93  ? -24.280 4.008   5.722   1.00 16.83  ? 92  TYR L CD2 1 
ATOM   691  C  CE1 . TYR A 1 93  ? -25.834 4.434   7.977   1.00 19.84  ? 92  TYR L CE1 1 
ATOM   692  C  CE2 . TYR A 1 93  ? -23.671 4.117   6.981   1.00 16.88  ? 92  TYR L CE2 1 
ATOM   693  C  CZ  . TYR A 1 93  ? -24.465 4.339   8.097   1.00 22.58  ? 92  TYR L CZ  1 
ATOM   694  O  OH  . TYR A 1 93  ? -23.914 4.458   9.347   1.00 19.56  ? 92  TYR L OH  1 
ATOM   695  N  N   . ASP A 1 94  ? -28.811 2.997   2.798   1.00 17.91  ? 93  ASP L N   1 
ATOM   696  C  CA  . ASP A 1 94  ? -29.679 3.057   1.617   1.00 22.55  ? 93  ASP L CA  1 
ATOM   697  C  C   . ASP A 1 94  ? -29.093 4.035   0.588   1.00 21.42  ? 93  ASP L C   1 
ATOM   698  O  O   . ASP A 1 94  ? -29.070 5.243   0.818   1.00 23.84  ? 93  ASP L O   1 
ATOM   699  C  CB  . ASP A 1 94  ? -31.090 3.474   2.030   1.00 24.03  ? 93  ASP L CB  1 
ATOM   700  C  CG  . ASP A 1 94  ? -32.100 3.345   0.897   1.00 39.81  ? 93  ASP L CG  1 
ATOM   701  O  OD1 . ASP A 1 94  ? -31.795 3.740   -0.255  1.00 31.19  ? 93  ASP L OD1 1 
ATOM   702  O  OD2 . ASP A 1 94  ? -33.211 2.843   1.167   1.00 42.80  ? 93  ASP L OD2 1 
ATOM   703  N  N   . CYS A 1 95  ? -28.609 3.515   -0.539  1.00 21.34  ? 94  CYS L N   1 
ATOM   704  C  CA  . CYS A 1 95  ? -27.990 4.361   -1.575  1.00 24.91  ? 94  CYS L CA  1 
ATOM   705  C  C   . CYS A 1 95  ? -28.887 5.482   -2.127  1.00 32.38  ? 94  CYS L C   1 
ATOM   706  O  O   . CYS A 1 95  ? -28.378 6.478   -2.660  1.00 23.05  ? 94  CYS L O   1 
ATOM   707  C  CB  . CYS A 1 95  ? -27.498 3.510   -2.754  1.00 23.05  ? 94  CYS L CB  1 
ATOM   708  S  SG  . CYS A 1 95  ? -26.134 2.378   -2.393  1.00 31.22  ? 94  CYS L SG  1 
ATOM   709  N  N   . SER A 1 96  ? -30.206 5.315   -2.020  1.00 24.84  ? 95  SER L N   1 
ATOM   710  C  CA  . SER A 1 96  ? -31.138 6.282   -2.607  1.00 33.41  ? 95  SER L CA  1 
ATOM   711  C  C   . SER A 1 96  ? -31.387 7.514   -1.721  1.00 37.65  ? 95  SER L C   1 
ATOM   712  O  O   . SER A 1 96  ? -31.999 8.482   -2.161  1.00 35.44  ? 95  SER L O   1 
ATOM   713  C  CB  . SER A 1 96  ? -32.470 5.608   -2.976  1.00 29.44  ? 95  SER L CB  1 
ATOM   714  O  OG  . SER A 1 96  ? -33.178 5.168   -1.819  1.00 34.08  ? 95  SER L OG  1 
ATOM   715  N  N   . SER A 1 97  A -30.901 7.491   -0.485  1.00 30.49  ? 95  SER L N   1 
ATOM   716  C  CA  . SER A 1 97  A -31.139 8.612   0.419   1.00 27.57  ? 95  SER L CA  1 
ATOM   717  C  C   . SER A 1 97  A -29.858 9.244   0.961   1.00 31.53  ? 95  SER L C   1 
ATOM   718  O  O   . SER A 1 97  A -29.910 10.113  1.831   1.00 32.69  ? 95  SER L O   1 
ATOM   719  C  CB  . SER A 1 97  A -32.023 8.171   1.582   1.00 30.70  ? 95  SER L CB  1 
ATOM   720  O  OG  . SER A 1 97  A -31.344 7.236   2.394   1.00 41.27  ? 95  SER L OG  1 
ATOM   721  N  N   . GLY A 1 98  B -28.713 8.805   0.456   1.00 26.67  ? 95  GLY L N   1 
ATOM   722  C  CA  . GLY A 1 98  B -27.424 9.341   0.880   1.00 28.12  ? 95  GLY L CA  1 
ATOM   723  C  C   . GLY A 1 98  B -26.304 8.480   0.337   1.00 24.68  ? 95  GLY L C   1 
ATOM   724  O  O   . GLY A 1 98  B -26.520 7.761   -0.638  1.00 22.76  ? 95  GLY L O   1 
ATOM   725  N  N   . ASP A 1 99  C -25.121 8.545   0.959   1.00 22.68  ? 95  ASP L N   1 
ATOM   726  C  CA  . ASP A 1 99  C -23.977 7.723   0.556   1.00 21.29  ? 95  ASP L CA  1 
ATOM   727  C  C   . ASP A 1 99  C -24.218 6.261   0.926   1.00 21.26  ? 95  ASP L C   1 
ATOM   728  O  O   . ASP A 1 99  C -24.948 5.982   1.873   1.00 19.39  ? 95  ASP L O   1 
ATOM   729  C  CB  . ASP A 1 99  C -22.675 8.220   1.215   1.00 22.58  ? 95  ASP L CB  1 
ATOM   730  C  CG  . ASP A 1 99  C -22.054 9.412   0.482   1.00 26.83  ? 95  ASP L CG  1 
ATOM   731  O  OD1 . ASP A 1 99  C -22.752 10.029  -0.341  1.00 21.24  ? 95  ASP L OD1 1 
ATOM   732  O  OD2 . ASP A 1 99  C -20.860 9.730   0.722   1.00 19.77  ? 95  ASP L OD2 1 
ATOM   733  N  N   . CYS A 1 100 D -23.606 5.334   0.178   1.00 16.82  ? 95  CYS L N   1 
ATOM   734  C  CA  . CYS A 1 100 D -23.831 3.901   0.369   1.00 16.08  ? 95  CYS L CA  1 
ATOM   735  C  C   . CYS A 1 100 D -23.147 3.317   1.609   1.00 19.82  ? 95  CYS L C   1 
ATOM   736  O  O   . CYS A 1 100 D -23.505 2.208   2.052   1.00 14.85  ? 95  CYS L O   1 
ATOM   737  C  CB  . CYS A 1 100 D -23.354 3.108   -0.855  1.00 21.36  ? 95  CYS L CB  1 
ATOM   738  S  SG  . CYS A 1 100 D -24.315 3.340   -2.389  1.00 27.60  ? 95  CYS L SG  1 
ATOM   739  N  N   . ALA A 1 101 ? -22.163 4.032   2.155   1.00 19.09  ? 96  ALA L N   1 
ATOM   740  C  CA  . ALA A 1 101 ? -21.338 3.481   3.247   1.00 21.13  ? 96  ALA L CA  1 
ATOM   741  C  C   . ALA A 1 101 ? -20.605 4.550   4.059   1.00 16.88  ? 96  ALA L C   1 
ATOM   742  O  O   . ALA A 1 101 ? -20.386 5.654   3.578   1.00 16.82  ? 96  ALA L O   1 
ATOM   743  C  CB  . ALA A 1 101 ? -20.325 2.476   2.688   1.00 20.44  ? 96  ALA L CB  1 
ATOM   744  N  N   . ALA A 1 102 ? -20.222 4.203   5.285   1.00 14.66  ? 97  ALA L N   1 
ATOM   745  C  CA  . ALA A 1 102 ? -19.404 5.077   6.122   1.00 14.83  ? 97  ALA L CA  1 
ATOM   746  C  C   . ALA A 1 102 ? -18.670 4.259   7.178   1.00 19.05  ? 97  ALA L C   1 
ATOM   747  O  O   . ALA A 1 102 ? -19.277 3.405   7.807   1.00 18.30  ? 97  ALA L O   1 
ATOM   748  C  CB  . ALA A 1 102 ? -20.267 6.148   6.812   1.00 14.59  ? 97  ALA L CB  1 
ATOM   749  N  N   . PHE A 1 103 ? -17.379 4.545   7.376   1.00 17.39  ? 98  PHE L N   1 
ATOM   750  C  CA  . PHE A 1 103 ? -16.582 3.924   8.443   1.00 17.86  ? 98  PHE L CA  1 
ATOM   751  C  C   . PHE A 1 103 ? -16.643 4.741   9.725   1.00 15.64  ? 98  PHE L C   1 
ATOM   752  O  O   . PHE A 1 103 ? -16.717 5.962   9.672   1.00 15.26  ? 98  PHE L O   1 
ATOM   753  C  CB  . PHE A 1 103 ? -15.103 3.834   8.021   1.00 15.60  ? 98  PHE L CB  1 
ATOM   754  C  CG  . PHE A 1 103 ? -14.795 2.672   7.120   1.00 14.30  ? 98  PHE L CG  1 
ATOM   755  C  CD1 . PHE A 1 103 ? -14.608 1.398   7.644   1.00 15.98  ? 98  PHE L CD1 1 
ATOM   756  C  CD2 . PHE A 1 103 ? -14.663 2.855   5.755   1.00 16.18  ? 98  PHE L CD2 1 
ATOM   757  C  CE1 . PHE A 1 103 ? -14.306 0.332   6.811   1.00 15.41  ? 98  PHE L CE1 1 
ATOM   758  C  CE2 . PHE A 1 103 ? -14.365 1.790   4.920   1.00 16.57  ? 98  PHE L CE2 1 
ATOM   759  C  CZ  . PHE A 1 103 ? -14.191 0.541   5.438   1.00 12.93  ? 98  PHE L CZ  1 
ATOM   760  N  N   . GLY A 1 104 ? -16.586 4.084   10.881  1.00 20.46  ? 99  GLY L N   1 
ATOM   761  C  CA  . GLY A 1 104 ? -16.359 4.810   12.123  1.00 21.00  ? 99  GLY L CA  1 
ATOM   762  C  C   . GLY A 1 104 ? -14.884 5.182   12.218  1.00 19.07  ? 99  GLY L C   1 
ATOM   763  O  O   . GLY A 1 104 ? -14.089 4.705   11.418  1.00 19.56  ? 99  GLY L O   1 
ATOM   764  N  N   . GLY A 1 105 ? -14.506 6.005   13.191  1.00 13.43  ? 100 GLY L N   1 
ATOM   765  C  CA  . GLY A 1 105 ? -13.156 6.549   13.222  1.00 19.15  ? 100 GLY L CA  1 
ATOM   766  C  C   . GLY A 1 105 ? -12.091 5.666   13.844  1.00 22.07  ? 100 GLY L C   1 
ATOM   767  O  O   . GLY A 1 105 ? -10.898 6.028   13.837  1.00 20.74  ? 100 GLY L O   1 
ATOM   768  N  N   . GLY A 1 106 ? -12.505 4.530   14.406  1.00 15.67  ? 101 GLY L N   1 
ATOM   769  C  CA  . GLY A 1 106 ? -11.558 3.563   14.946  1.00 15.72  ? 101 GLY L CA  1 
ATOM   770  C  C   . GLY A 1 106 ? -11.370 3.582   16.455  1.00 17.40  ? 101 GLY L C   1 
ATOM   771  O  O   . GLY A 1 106 ? -11.564 4.609   17.095  1.00 20.10  ? 101 GLY L O   1 
ATOM   772  N  N   . THR A 1 107 ? -11.007 2.430   17.025  1.00 17.49  ? 102 THR L N   1 
ATOM   773  C  CA  . THR A 1 107 ? -10.644 2.340   18.433  1.00 17.25  ? 102 THR L CA  1 
ATOM   774  C  C   . THR A 1 107 ? -9.317  1.615   18.564  1.00 18.03  ? 102 THR L C   1 
ATOM   775  O  O   . THR A 1 107 ? -9.202  0.459   18.175  1.00 19.85  ? 102 THR L O   1 
ATOM   776  C  CB  . THR A 1 107 ? -11.664 1.519   19.246  1.00 20.05  ? 102 THR L CB  1 
ATOM   777  O  OG1 . THR A 1 107 ? -12.973 2.090   19.128  1.00 20.34  ? 102 THR L OG1 1 
ATOM   778  C  CG2 . THR A 1 107 ? -11.251 1.482   20.723  1.00 16.19  ? 102 THR L CG2 1 
ATOM   779  N  N   . GLU A 1 108 ? -8.322  2.277   19.134  1.00 18.63  ? 103 GLU L N   1 
ATOM   780  C  CA  . GLU A 1 108 ? -7.044  1.624   19.403  1.00 19.45  ? 103 GLU L CA  1 
ATOM   781  C  C   . GLU A 1 108 ? -7.127  0.854   20.718  1.00 20.08  ? 103 GLU L C   1 
ATOM   782  O  O   . GLU A 1 108 ? -7.398  1.449   21.756  1.00 19.53  ? 103 GLU L O   1 
ATOM   783  C  CB  . GLU A 1 108 ? -5.923  2.655   19.517  1.00 21.12  ? 103 GLU L CB  1 
ATOM   784  C  CG  . GLU A 1 108 ? -5.731  3.503   18.280  1.00 37.13  ? 103 GLU L CG  1 
ATOM   785  C  CD  . GLU A 1 108 ? -4.545  4.442   18.404  1.00 48.30  ? 103 GLU L CD  1 
ATOM   786  O  OE1 . GLU A 1 108 ? -3.916  4.472   19.487  1.00 57.38  ? 103 GLU L OE1 1 
ATOM   787  O  OE2 . GLU A 1 108 ? -4.238  5.147   17.417  1.00 48.44  ? 103 GLU L OE2 1 
ATOM   788  N  N   . VAL A 1 109 ? -6.875  -0.457  20.674  1.00 19.65  ? 104 VAL L N   1 
ATOM   789  C  CA  . VAL A 1 109 ? -6.924  -1.296  21.876  1.00 14.39  ? 104 VAL L CA  1 
ATOM   790  C  C   . VAL A 1 109 ? -5.498  -1.681  22.312  1.00 18.53  ? 104 VAL L C   1 
ATOM   791  O  O   . VAL A 1 109 ? -4.765  -2.340  21.576  1.00 16.35  ? 104 VAL L O   1 
ATOM   792  C  CB  . VAL A 1 109 ? -7.784  -2.556  21.661  1.00 16.65  ? 104 VAL L CB  1 
ATOM   793  C  CG1 . VAL A 1 109 ? -7.709  -3.451  22.884  1.00 19.84  ? 104 VAL L CG1 1 
ATOM   794  C  CG2 . VAL A 1 109 ? -9.260  -2.165  21.345  1.00 13.65  ? 104 VAL L CG2 1 
ATOM   795  N  N   . VAL A 1 110 ? -5.102  -1.217  23.490  1.00 17.09  ? 105 VAL L N   1 
ATOM   796  C  CA  . VAL A 1 110 ? -3.810  -1.576  24.088  1.00 15.32  ? 105 VAL L CA  1 
ATOM   797  C  C   . VAL A 1 110 ? -4.056  -2.654  25.147  1.00 20.51  ? 105 VAL L C   1 
ATOM   798  O  O   . VAL A 1 110 ? -4.989  -2.544  25.927  1.00 16.64  ? 105 VAL L O   1 
ATOM   799  C  CB  . VAL A 1 110 ? -3.141  -0.342  24.710  1.00 19.02  ? 105 VAL L CB  1 
ATOM   800  C  CG1 . VAL A 1 110 ? -1.982  -0.745  25.629  1.00 17.15  ? 105 VAL L CG1 1 
ATOM   801  C  CG2 . VAL A 1 110 ? -2.688  0.642   23.593  1.00 17.31  ? 105 VAL L CG2 1 
ATOM   802  N  N   . VAL A 1 111 ? -3.239  -3.708  25.154  1.00 16.32  ? 106 VAL L N   1 
ATOM   803  C  CA  . VAL A 1 111 ? -3.471  -4.862  26.028  1.00 15.79  ? 106 VAL L CA  1 
ATOM   804  C  C   . VAL A 1 111 ? -2.359  -4.958  27.075  1.00 20.29  ? 106 VAL L C   1 
ATOM   805  O  O   . VAL A 1 111 ? -1.172  -5.016  26.731  1.00 16.33  ? 106 VAL L O   1 
ATOM   806  C  CB  . VAL A 1 111 ? -3.519  -6.162  25.198  1.00 15.36  ? 106 VAL L CB  1 
ATOM   807  C  CG1 . VAL A 1 111 ? -3.666  -7.415  26.099  1.00 16.88  ? 106 VAL L CG1 1 
ATOM   808  C  CG2 . VAL A 1 111 ? -4.659  -6.088  24.170  1.00 15.24  ? 106 VAL L CG2 1 
ATOM   809  N  N   . ARG A 1 112 ? -2.735  -4.984  28.348  1.00 17.77  ? 107 ARG L N   1 
ATOM   810  C  CA  . ARG A 1 112 ? -1.744  -5.069  29.424  1.00 24.16  ? 107 ARG L CA  1 
ATOM   811  C  C   . ARG A 1 112 ? -1.389  -6.506  29.825  1.00 26.00  ? 107 ARG L C   1 
ATOM   812  O  O   . ARG A 1 112 ? -2.213  -7.207  30.407  1.00 23.70  ? 107 ARG L O   1 
ATOM   813  C  CB  . ARG A 1 112 ? -2.255  -4.366  30.672  1.00 19.69  ? 107 ARG L CB  1 
ATOM   814  C  CG  . ARG A 1 112 ? -2.323  -2.891  30.607  1.00 22.55  ? 107 ARG L CG  1 
ATOM   815  C  CD  . ARG A 1 112 ? -2.664  -2.414  32.021  1.00 25.75  ? 107 ARG L CD  1 
ATOM   816  N  NE  . ARG A 1 112 ? -3.963  -1.890  31.867  1.00 35.48  ? 107 ARG L NE  1 
ATOM   817  C  CZ  . ARG A 1 112 ? -5.149  -2.154  32.382  1.00 25.08  ? 107 ARG L CZ  1 
ATOM   818  N  NH1 . ARG A 1 112 ? -6.075  -1.438  31.809  1.00 22.65  ? 107 ARG L NH1 1 
ATOM   819  N  NH2 . ARG A 1 112 ? -5.462  -2.955  33.388  1.00 25.84  ? 107 ARG L NH2 1 
ATOM   820  N  N   . GLY A 1 113 ? -0.153  -6.922  29.553  1.00 22.05  ? 108 GLY L N   1 
ATOM   821  C  CA  . GLY A 1 113 ? 0.322   -8.234  29.965  1.00 24.82  ? 108 GLY L CA  1 
ATOM   822  C  C   . GLY A 1 113 ? 1.286   -8.167  31.148  1.00 28.16  ? 108 GLY L C   1 
ATOM   823  O  O   . GLY A 1 113 ? 1.344   -7.162  31.851  1.00 21.41  ? 108 GLY L O   1 
ATOM   824  N  N   . ASP A 1 114 ? 2.038   -9.240  31.377  1.00 25.43  ? 109 ASP L N   1 
ATOM   825  C  CA  . ASP A 1 114 ? 2.980   -9.294  32.500  1.00 27.87  ? 109 ASP L CA  1 
ATOM   826  C  C   . ASP A 1 114 ? 4.145   -8.330  32.294  1.00 26.51  ? 109 ASP L C   1 
ATOM   827  O  O   . ASP A 1 114 ? 4.645   -8.187  31.178  1.00 27.75  ? 109 ASP L O   1 
ATOM   828  C  CB  . ASP A 1 114 ? 3.520   -10.715 32.673  1.00 32.15  ? 109 ASP L CB  1 
ATOM   829  C  CG  . ASP A 1 114 ? 2.434   -11.718 33.031  1.00 36.51  ? 109 ASP L CG  1 
ATOM   830  O  OD1 . ASP A 1 114 ? 1.475   -11.349 33.738  1.00 33.92  ? 109 ASP L OD1 1 
ATOM   831  O  OD2 . ASP A 1 114 ? 2.539   -12.879 32.598  1.00 49.85  ? 109 ASP L OD2 1 
ATOM   832  N  N   . PRO A 1 115 ? 4.583   -7.662  33.368  1.00 25.90  ? 110 PRO L N   1 
ATOM   833  C  CA  . PRO A 1 115 ? 5.696   -6.715  33.261  1.00 24.18  ? 110 PRO L CA  1 
ATOM   834  C  C   . PRO A 1 115 ? 7.029   -7.381  32.914  1.00 31.78  ? 110 PRO L C   1 
ATOM   835  O  O   . PRO A 1 115 ? 7.318   -8.483  33.381  1.00 23.89  ? 110 PRO L O   1 
ATOM   836  C  CB  . PRO A 1 115 ? 5.743   -6.068  34.652  1.00 27.73  ? 110 PRO L CB  1 
ATOM   837  C  CG  . PRO A 1 115 ? 5.083   -7.034  35.547  1.00 40.48  ? 110 PRO L CG  1 
ATOM   838  C  CD  . PRO A 1 115 ? 4.017   -7.697  34.726  1.00 34.09  ? 110 PRO L CD  1 
ATOM   839  N  N   . VAL A 1 116 ? 7.817   -6.719  32.068  1.00 27.20  ? 111 VAL L N   1 
ATOM   840  C  CA  . VAL A 1 116 ? 9.145   -7.187  31.691  1.00 20.71  ? 111 VAL L CA  1 
ATOM   841  C  C   . VAL A 1 116 ? 10.079  -5.992  31.654  1.00 25.10  ? 111 VAL L C   1 
ATOM   842  O  O   . VAL A 1 116 ? 9.772   -4.990  31.011  1.00 22.03  ? 111 VAL L O   1 
ATOM   843  C  CB  . VAL A 1 116 ? 9.156   -7.871  30.297  1.00 20.68  ? 111 VAL L CB  1 
ATOM   844  C  CG1 . VAL A 1 116 ? 10.551  -8.380  29.954  1.00 22.98  ? 111 VAL L CG1 1 
ATOM   845  C  CG2 . VAL A 1 116 ? 8.154   -9.011  30.239  1.00 22.40  ? 111 VAL L CG2 1 
ATOM   846  N  N   . ALA A 1 117 ? 11.209  -6.076  32.358  1.00 22.32  ? 112 ALA L N   1 
ATOM   847  C  CA  . ALA A 1 117 ? 12.198  -4.994  32.313  1.00 21.86  ? 112 ALA L CA  1 
ATOM   848  C  C   . ALA A 1 117 ? 12.972  -5.048  31.000  1.00 18.82  ? 112 ALA L C   1 
ATOM   849  O  O   . ALA A 1 117 ? 13.255  -6.136  30.496  1.00 23.52  ? 112 ALA L O   1 
ATOM   850  C  CB  . ALA A 1 117 ? 13.166  -5.086  33.526  1.00 25.45  ? 112 ALA L CB  1 
ATOM   851  N  N   . PRO A 1 118 ? 13.328  -3.882  30.440  1.00 17.92  ? 113 PRO L N   1 
ATOM   852  C  CA  . PRO A 1 118 ? 14.055  -3.854  29.164  1.00 18.28  ? 113 PRO L CA  1 
ATOM   853  C  C   . PRO A 1 118 ? 15.556  -4.158  29.318  1.00 22.76  ? 113 PRO L C   1 
ATOM   854  O  O   . PRO A 1 118 ? 16.111  -3.929  30.384  1.00 25.31  ? 113 PRO L O   1 
ATOM   855  C  CB  . PRO A 1 118 ? 13.896  -2.400  28.722  1.00 18.80  ? 113 PRO L CB  1 
ATOM   856  C  CG  . PRO A 1 118 ? 13.821  -1.639  30.002  1.00 20.12  ? 113 PRO L CG  1 
ATOM   857  C  CD  . PRO A 1 118 ? 13.081  -2.522  30.969  1.00 19.77  ? 113 PRO L CD  1 
ATOM   858  N  N   . THR A 1 119 ? 16.198  -4.677  28.274  1.00 23.55  ? 114 THR L N   1 
ATOM   859  C  CA  . THR A 1 119 ? 17.656  -4.572  28.169  1.00 24.85  ? 114 THR L CA  1 
ATOM   860  C  C   . THR A 1 119 ? 17.951  -3.438  27.181  1.00 27.92  ? 114 THR L C   1 
ATOM   861  O  O   . THR A 1 119 ? 17.109  -3.102  26.349  1.00 22.77  ? 114 THR L O   1 
ATOM   862  C  CB  . THR A 1 119 ? 18.334  -5.878  27.709  1.00 27.89  ? 114 THR L CB  1 
ATOM   863  O  OG1 . THR A 1 119 ? 17.743  -6.319  26.483  1.00 25.73  ? 114 THR L OG1 1 
ATOM   864  C  CG2 . THR A 1 119 ? 18.186  -6.971  28.768  1.00 29.52  ? 114 THR L CG2 1 
ATOM   865  N  N   . VAL A 1 120 ? 19.131  -2.833  27.270  1.00 24.19  ? 115 VAL L N   1 
ATOM   866  C  CA  . VAL A 1 120 ? 19.389  -1.615  26.501  1.00 18.93  ? 115 VAL L CA  1 
ATOM   867  C  C   . VAL A 1 120 ? 20.709  -1.686  25.723  1.00 23.17  ? 115 VAL L C   1 
ATOM   868  O  O   . VAL A 1 120 ? 21.700  -2.215  26.226  1.00 21.87  ? 115 VAL L O   1 
ATOM   869  C  CB  . VAL A 1 120 ? 19.402  -0.374  27.439  1.00 18.18  ? 115 VAL L CB  1 
ATOM   870  C  CG1 . VAL A 1 120 ? 19.686  0.913   26.665  1.00 22.01  ? 115 VAL L CG1 1 
ATOM   871  C  CG2 . VAL A 1 120 ? 18.071  -0.249  28.203  1.00 20.13  ? 115 VAL L CG2 1 
ATOM   872  N  N   . LEU A 1 121 ? 20.720  -1.125  24.517  1.00 17.63  ? 116 LEU L N   1 
ATOM   873  C  CA  . LEU A 1 121 ? 21.917  -1.096  23.684  1.00 24.65  ? 116 LEU L CA  1 
ATOM   874  C  C   . LEU A 1 121 ? 22.172  0.327   23.209  1.00 24.46  ? 116 LEU L C   1 
ATOM   875  O  O   . LEU A 1 121 ? 21.235  1.047   22.884  1.00 20.28  ? 116 LEU L O   1 
ATOM   876  C  CB  . LEU A 1 121 ? 21.715  -1.986  22.462  1.00 20.10  ? 116 LEU L CB  1 
ATOM   877  C  CG  . LEU A 1 121 ? 21.300  -3.437  22.713  1.00 29.72  ? 116 LEU L CG  1 
ATOM   878  C  CD1 . LEU A 1 121 ? 20.653  -4.018  21.458  1.00 29.50  ? 116 LEU L CD1 1 
ATOM   879  C  CD2 . LEU A 1 121 ? 22.502  -4.249  23.112  1.00 29.96  ? 116 LEU L CD2 1 
ATOM   880  N  N   . ILE A 1 122 ? 23.434  0.740   23.160  1.00 22.74  ? 117 ILE L N   1 
ATOM   881  C  CA  . ILE A 1 122 ? 23.758  2.035   22.576  1.00 19.70  ? 117 ILE L CA  1 
ATOM   882  C  C   . ILE A 1 122 ? 24.759  1.842   21.428  1.00 29.57  ? 117 ILE L C   1 
ATOM   883  O  O   . ILE A 1 122 ? 25.684  1.026   21.530  1.00 23.63  ? 117 ILE L O   1 
ATOM   884  C  CB  . ILE A 1 122 ? 24.252  3.058   23.649  1.00 27.79  ? 117 ILE L CB  1 
ATOM   885  C  CG1 . ILE A 1 122 ? 24.389  4.464   23.045  1.00 23.85  ? 117 ILE L CG1 1 
ATOM   886  C  CG2 . ILE A 1 122 ? 25.565  2.590   24.307  1.00 24.79  ? 117 ILE L CG2 1 
ATOM   887  C  CD1 . ILE A 1 122 ? 24.514  5.572   24.077  1.00 26.52  ? 117 ILE L CD1 1 
ATOM   888  N  N   . PHE A 1 123 ? 24.539  2.555   20.324  1.00 24.05  ? 118 PHE L N   1 
ATOM   889  C  CA  . PHE A 1 123 ? 25.387  2.428   19.138  1.00 22.11  ? 118 PHE L CA  1 
ATOM   890  C  C   . PHE A 1 123 ? 26.023  3.757   18.790  1.00 27.03  ? 118 PHE L C   1 
ATOM   891  O  O   . PHE A 1 123 ? 25.326  4.694   18.415  1.00 27.27  ? 118 PHE L O   1 
ATOM   892  C  CB  . PHE A 1 123 ? 24.577  1.963   17.923  1.00 23.65  ? 118 PHE L CB  1 
ATOM   893  C  CG  . PHE A 1 123 ? 23.924  0.630   18.098  1.00 26.69  ? 118 PHE L CG  1 
ATOM   894  C  CD1 . PHE A 1 123 ? 24.652  -0.538  17.953  1.00 20.99  ? 118 PHE L CD1 1 
ATOM   895  C  CD2 . PHE A 1 123 ? 22.577  0.541   18.404  1.00 28.21  ? 118 PHE L CD2 1 
ATOM   896  C  CE1 . PHE A 1 123 ? 24.045  -1.776  18.102  1.00 25.18  ? 118 PHE L CE1 1 
ATOM   897  C  CE2 . PHE A 1 123 ? 21.963  -0.693  18.566  1.00 28.52  ? 118 PHE L CE2 1 
ATOM   898  C  CZ  . PHE A 1 123 ? 22.700  -1.855  18.414  1.00 26.84  ? 118 PHE L CZ  1 
ATOM   899  N  N   . PRO A 1 124 ? 27.356  3.844   18.902  1.00 27.64  ? 119 PRO L N   1 
ATOM   900  C  CA  . PRO A 1 124 ? 28.078  5.057   18.503  1.00 25.75  ? 119 PRO L CA  1 
ATOM   901  C  C   . PRO A 1 124 ? 27.998  5.283   16.994  1.00 24.40  ? 119 PRO L C   1 
ATOM   902  O  O   . PRO A 1 124 ? 27.738  4.337   16.248  1.00 27.85  ? 119 PRO L O   1 
ATOM   903  C  CB  . PRO A 1 124 ? 29.521  4.771   18.945  1.00 33.87  ? 119 PRO L CB  1 
ATOM   904  C  CG  . PRO A 1 124 ? 29.612  3.297   19.046  1.00 36.09  ? 119 PRO L CG  1 
ATOM   905  C  CD  . PRO A 1 124 ? 28.249  2.807   19.441  1.00 26.18  ? 119 PRO L CD  1 
ATOM   906  N  N   . PRO A 1 125 ? 28.200  6.530   16.541  1.00 25.77  ? 120 PRO L N   1 
ATOM   907  C  CA  . PRO A 1 125 ? 28.040  6.849   15.118  1.00 26.08  ? 120 PRO L CA  1 
ATOM   908  C  C   . PRO A 1 125 ? 29.118  6.150   14.311  1.00 32.45  ? 120 PRO L C   1 
ATOM   909  O  O   . PRO A 1 125 ? 30.268  6.158   14.746  1.00 31.44  ? 120 PRO L O   1 
ATOM   910  C  CB  . PRO A 1 125 ? 28.273  8.362   15.054  1.00 29.86  ? 120 PRO L CB  1 
ATOM   911  C  CG  . PRO A 1 125 ? 28.312  8.839   16.471  1.00 29.94  ? 120 PRO L CG  1 
ATOM   912  C  CD  . PRO A 1 125 ? 28.661  7.681   17.329  1.00 27.84  ? 120 PRO L CD  1 
ATOM   913  N  N   . ALA A 1 126 ? 28.762  5.548   13.179  1.00 30.77  ? 121 ALA L N   1 
ATOM   914  C  CA  . ALA A 1 126 ? 29.759  4.991   12.270  1.00 31.86  ? 121 ALA L CA  1 
ATOM   915  C  C   . ALA A 1 126 ? 30.711  6.099   11.808  1.00 37.63  ? 121 ALA L C   1 
ATOM   916  O  O   . ALA A 1 126 ? 30.307  7.258   11.670  1.00 28.59  ? 121 ALA L O   1 
ATOM   917  C  CB  . ALA A 1 126 ? 29.084  4.349   11.081  1.00 27.21  ? 121 ALA L CB  1 
ATOM   918  N  N   . ALA A 1 127 ? 31.973  5.740   11.578  1.00 40.52  ? 122 ALA L N   1 
ATOM   919  C  CA  . ALA A 1 127 ? 33.011  6.707   11.199  1.00 39.05  ? 122 ALA L CA  1 
ATOM   920  C  C   . ALA A 1 127 ? 32.616  7.581   10.005  1.00 36.20  ? 122 ALA L C   1 
ATOM   921  O  O   . ALA A 1 127 ? 32.914  8.773   9.971   1.00 43.07  ? 122 ALA L O   1 
ATOM   922  C  CB  . ALA A 1 127 ? 34.326  5.985   10.921  1.00 44.05  ? 122 ALA L CB  1 
ATOM   923  N  N   . ASP A 1 128 ? 31.914  6.985   9.046   1.00 43.79  ? 123 ASP L N   1 
ATOM   924  C  CA  . ASP A 1 128 ? 31.431  7.708   7.871   1.00 40.77  ? 123 ASP L CA  1 
ATOM   925  C  C   . ASP A 1 128 ? 30.523  8.891   8.181   1.00 41.04  ? 123 ASP L C   1 
ATOM   926  O  O   . ASP A 1 128 ? 30.356  9.778   7.340   1.00 39.46  ? 123 ASP L O   1 
ATOM   927  C  CB  . ASP A 1 128 ? 30.670  6.757   6.942   1.00 43.86  ? 123 ASP L CB  1 
ATOM   928  C  CG  . ASP A 1 128 ? 31.582  5.805   6.212   1.00 63.72  ? 123 ASP L CG  1 
ATOM   929  O  OD1 . ASP A 1 128 ? 32.807  6.063   6.186   1.00 66.76  ? 123 ASP L OD1 1 
ATOM   930  O  OD2 . ASP A 1 128 ? 31.072  4.804   5.659   1.00 75.50  ? 123 ASP L OD2 1 
ATOM   931  N  N   . GLN A 1 129 ? 29.921  8.900   9.366   1.00 35.82  ? 124 GLN L N   1 
ATOM   932  C  CA  . GLN A 1 129 ? 28.908  9.904   9.683   1.00 35.34  ? 124 GLN L CA  1 
ATOM   933  C  C   . GLN A 1 129 ? 29.465  11.309  9.897   1.00 42.96  ? 124 GLN L C   1 
ATOM   934  O  O   . GLN A 1 129 ? 28.913  12.286  9.376   1.00 36.36  ? 124 GLN L O   1 
ATOM   935  C  CB  . GLN A 1 129 ? 28.081  9.497   10.907  1.00 39.62  ? 124 GLN L CB  1 
ATOM   936  C  CG  . GLN A 1 129 ? 27.007  8.475   10.623  1.00 30.55  ? 124 GLN L CG  1 
ATOM   937  C  CD  . GLN A 1 129 ? 25.918  8.496   11.669  1.00 33.13  ? 124 GLN L CD  1 
ATOM   938  O  OE1 . GLN A 1 129 ? 25.299  9.535   11.905  1.00 32.87  ? 124 GLN L OE1 1 
ATOM   939  N  NE2 . GLN A 1 129 ? 25.678  7.349   12.310  1.00 31.37  ? 124 GLN L NE2 1 
ATOM   940  N  N   . VAL A 1 130 ? 30.541  11.408  10.678  1.00 39.44  ? 125 VAL L N   1 
ATOM   941  C  CA  . VAL A 1 130 ? 31.094  12.708  11.051  1.00 42.79  ? 125 VAL L CA  1 
ATOM   942  C  C   . VAL A 1 130 ? 31.457  13.547  9.829   1.00 41.21  ? 125 VAL L C   1 
ATOM   943  O  O   . VAL A 1 130 ? 31.355  14.777  9.855   1.00 41.70  ? 125 VAL L O   1 
ATOM   944  C  CB  . VAL A 1 130 ? 32.325  12.580  11.980  1.00 49.22  ? 125 VAL L CB  1 
ATOM   945  C  CG1 . VAL A 1 130 ? 31.955  11.825  13.243  1.00 55.40  ? 125 VAL L CG1 1 
ATOM   946  C  CG2 . VAL A 1 130 ? 33.469  11.887  11.267  1.00 52.08  ? 125 VAL L CG2 1 
ATOM   947  N  N   . ALA A 1 131 ? 31.842  12.874  8.749   1.00 43.04  ? 126 ALA L N   1 
ATOM   948  C  CA  . ALA A 1 131 ? 32.205  13.554  7.512   1.00 39.99  ? 126 ALA L CA  1 
ATOM   949  C  C   . ALA A 1 131 ? 31.031  14.345  6.920   1.00 51.55  ? 126 ALA L C   1 
ATOM   950  O  O   . ALA A 1 131 ? 31.232  15.358  6.247   1.00 52.08  ? 126 ALA L O   1 
ATOM   951  C  CB  . ALA A 1 131 ? 32.745  12.553  6.501   1.00 43.45  ? 126 ALA L CB  1 
ATOM   952  N  N   . THR A 1 132 ? 29.807  13.898  7.184   1.00 38.40  ? 127 THR L N   1 
ATOM   953  C  CA  . THR A 1 132 ? 28.633  14.519  6.580   1.00 39.13  ? 127 THR L CA  1 
ATOM   954  C  C   . THR A 1 132 ? 28.255  15.819  7.272   1.00 39.95  ? 127 THR L C   1 
ATOM   955  O  O   . THR A 1 132 ? 27.433  16.581  6.766   1.00 39.67  ? 127 THR L O   1 
ATOM   956  C  CB  . THR A 1 132 ? 27.400  13.602  6.651   1.00 39.92  ? 127 THR L CB  1 
ATOM   957  O  OG1 . THR A 1 132 ? 26.958  13.517  8.012   1.00 34.90  ? 127 THR L OG1 1 
ATOM   958  C  CG2 . THR A 1 132 ? 27.718  12.212  6.116   1.00 30.95  ? 127 THR L CG2 1 
ATOM   959  N  N   . GLY A 1 133 ? 28.826  16.054  8.447   1.00 35.25  ? 128 GLY L N   1 
ATOM   960  C  CA  . GLY A 1 133 ? 28.534  17.259  9.199   1.00 40.20  ? 128 GLY L CA  1 
ATOM   961  C  C   . GLY A 1 133 ? 27.531  17.053  10.322  1.00 45.30  ? 128 GLY L C   1 
ATOM   962  O  O   . GLY A 1 133 ? 27.456  17.861  11.253  1.00 39.86  ? 128 GLY L O   1 
ATOM   963  N  N   . THR A 1 134 ? 26.751  15.977  10.235  1.00 39.94  ? 129 THR L N   1 
ATOM   964  C  CA  . THR A 1 134 ? 25.833  15.619  11.312  1.00 38.44  ? 129 THR L CA  1 
ATOM   965  C  C   . THR A 1 134 ? 26.021  14.168  11.757  1.00 37.26  ? 129 THR L C   1 
ATOM   966  O  O   . THR A 1 134 ? 26.412  13.298  10.969  1.00 33.17  ? 129 THR L O   1 
ATOM   967  C  CB  . THR A 1 134 ? 24.356  15.866  10.935  1.00 40.20  ? 129 THR L CB  1 
ATOM   968  O  OG1 . THR A 1 134 ? 24.034  15.130  9.750   1.00 48.65  ? 129 THR L OG1 1 
ATOM   969  C  CG2 . THR A 1 134 ? 24.107  17.353  10.689  1.00 45.58  ? 129 THR L CG2 1 
ATOM   970  N  N   . VAL A 1 135 ? 25.727  13.922  13.029  1.00 32.00  ? 130 VAL L N   1 
ATOM   971  C  CA  . VAL A 1 135 ? 25.989  12.638  13.658  1.00 30.92  ? 130 VAL L CA  1 
ATOM   972  C  C   . VAL A 1 135 ? 24.747  12.174  14.411  1.00 33.66  ? 130 VAL L C   1 
ATOM   973  O  O   . VAL A 1 135 ? 24.129  12.961  15.125  1.00 28.29  ? 130 VAL L O   1 
ATOM   974  C  CB  . VAL A 1 135 ? 27.189  12.772  14.614  1.00 32.23  ? 130 VAL L CB  1 
ATOM   975  C  CG1 . VAL A 1 135 ? 26.995  11.972  15.867  1.00 34.92  ? 130 VAL L CG1 1 
ATOM   976  C  CG2 . VAL A 1 135 ? 28.473  12.378  13.909  1.00 35.95  ? 130 VAL L CG2 1 
ATOM   977  N  N   . THR A 1 136 ? 24.377  10.906  14.232  1.00 30.30  ? 131 THR L N   1 
ATOM   978  C  CA  . THR A 1 136 ? 23.183  10.344  14.877  1.00 25.92  ? 131 THR L CA  1 
ATOM   979  C  C   . THR A 1 136 ? 23.575  9.160   15.761  1.00 21.87  ? 131 THR L C   1 
ATOM   980  O  O   . THR A 1 136 ? 24.133  8.175   15.270  1.00 24.55  ? 131 THR L O   1 
ATOM   981  C  CB  . THR A 1 136 ? 22.135  9.910   13.817  1.00 31.87  ? 131 THR L CB  1 
ATOM   982  O  OG1 . THR A 1 136 ? 21.700  11.058  13.083  1.00 32.72  ? 131 THR L OG1 1 
ATOM   983  C  CG2 . THR A 1 136 ? 20.914  9.266   14.457  1.00 23.95  ? 131 THR L CG2 1 
ATOM   984  N  N   . ILE A 1 137 ? 23.321  9.270   17.064  1.00 19.74  ? 132 ILE L N   1 
ATOM   985  C  CA  . ILE A 1 137 ? 23.600  8.178   17.997  1.00 21.49  ? 132 ILE L CA  1 
ATOM   986  C  C   . ILE A 1 137 ? 22.305  7.434   18.275  1.00 25.19  ? 132 ILE L C   1 
ATOM   987  O  O   . ILE A 1 137 ? 21.281  8.077   18.465  1.00 25.05  ? 132 ILE L O   1 
ATOM   988  C  CB  . ILE A 1 137 ? 24.143  8.725   19.333  1.00 22.16  ? 132 ILE L CB  1 
ATOM   989  C  CG1 . ILE A 1 137 ? 25.256  9.739   19.070  1.00 28.30  ? 132 ILE L CG1 1 
ATOM   990  C  CG2 . ILE A 1 137 ? 24.592  7.571   20.240  1.00 20.15  ? 132 ILE L CG2 1 
ATOM   991  C  CD1 . ILE A 1 137 ? 25.663  10.520  20.282  1.00 34.96  ? 132 ILE L CD1 1 
ATOM   992  N  N   . VAL A 1 138 ? 22.350  6.094   18.298  1.00 25.44  ? 133 VAL L N   1 
ATOM   993  C  CA  . VAL A 1 138 ? 21.138  5.275   18.415  1.00 21.80  ? 133 VAL L CA  1 
ATOM   994  C  C   . VAL A 1 138 ? 21.102  4.461   19.703  1.00 26.75  ? 133 VAL L C   1 
ATOM   995  O  O   . VAL A 1 138 ? 22.055  3.762   20.026  1.00 21.75  ? 133 VAL L O   1 
ATOM   996  C  CB  . VAL A 1 138 ? 20.966  4.294   17.213  1.00 21.38  ? 133 VAL L CB  1 
ATOM   997  C  CG1 . VAL A 1 138 ? 19.671  3.461   17.369  1.00 20.68  ? 133 VAL L CG1 1 
ATOM   998  C  CG2 . VAL A 1 138 ? 20.944  5.064   15.903  1.00 21.58  ? 133 VAL L CG2 1 
ATOM   999  N  N   . CYS A 1 139 ? 19.989  4.547   20.429  1.00 20.87  ? 134 CYS L N   1 
ATOM   1000 C  CA  . CYS A 1 139 ? 19.783  3.741   21.625  1.00 17.51  ? 134 CYS L CA  1 
ATOM   1001 C  C   . CYS A 1 139 ? 18.561  2.848   21.428  1.00 25.09  ? 134 CYS L C   1 
ATOM   1002 O  O   . CYS A 1 139 ? 17.539  3.305   20.909  1.00 22.97  ? 134 CYS L O   1 
ATOM   1003 C  CB  . CYS A 1 139 ? 19.573  4.658   22.834  1.00 17.18  ? 134 CYS L CB  1 
ATOM   1004 S  SG  . CYS A 1 139 ? 19.308  3.794   24.371  1.00 25.46  ? 134 CYS L SG  1 
ATOM   1005 N  N   . VAL A 1 140 ? 18.665  1.580   21.824  1.00 18.49  ? 135 VAL L N   1 
ATOM   1006 C  CA  . VAL A 1 140 ? 17.540  0.655   21.698  1.00 20.95  ? 135 VAL L CA  1 
ATOM   1007 C  C   . VAL A 1 140 ? 17.155  0.030   23.036  1.00 23.00  ? 135 VAL L C   1 
ATOM   1008 O  O   . VAL A 1 140 ? 18.027  -0.429  23.790  1.00 18.98  ? 135 VAL L O   1 
ATOM   1009 C  CB  . VAL A 1 140 ? 17.848  -0.487  20.708  1.00 25.77  ? 135 VAL L CB  1 
ATOM   1010 C  CG1 . VAL A 1 140 ? 16.723  -1.519  20.718  1.00 27.16  ? 135 VAL L CG1 1 
ATOM   1011 C  CG2 . VAL A 1 140 ? 18.069  0.057   19.296  1.00 21.85  ? 135 VAL L CG2 1 
ATOM   1012 N  N   . ALA A 1 141 ? 15.857  0.023   23.333  1.00 16.25  ? 136 ALA L N   1 
ATOM   1013 C  CA  . ALA A 1 141 ? 15.336  -0.678  24.498  1.00 18.53  ? 136 ALA L CA  1 
ATOM   1014 C  C   . ALA A 1 141 ? 14.546  -1.898  24.018  1.00 22.39  ? 136 ALA L C   1 
ATOM   1015 O  O   . ALA A 1 141 ? 13.557  -1.752  23.288  1.00 22.88  ? 136 ALA L O   1 
ATOM   1016 C  CB  . ALA A 1 141 ? 14.459  0.248   25.345  1.00 18.19  ? 136 ALA L CB  1 
ATOM   1017 N  N   . ASN A 1 142 ? 14.989  -3.092  24.424  1.00 19.31  ? 137 ASN L N   1 
ATOM   1018 C  CA  . ASN A 1 142 ? 14.426  -4.358  23.929  1.00 27.77  ? 137 ASN L CA  1 
ATOM   1019 C  C   . ASN A 1 142 ? 13.351  -4.963  24.823  1.00 26.28  ? 137 ASN L C   1 
ATOM   1020 O  O   . ASN A 1 142 ? 13.537  -5.049  26.037  1.00 22.96  ? 137 ASN L O   1 
ATOM   1021 C  CB  . ASN A 1 142 ? 15.513  -5.433  23.815  1.00 25.78  ? 137 ASN L CB  1 
ATOM   1022 C  CG  . ASN A 1 142 ? 16.736  -4.963  23.060  1.00 37.09  ? 137 ASN L CG  1 
ATOM   1023 O  OD1 . ASN A 1 142 ? 16.625  -4.399  21.975  1.00 35.80  ? 137 ASN L OD1 1 
ATOM   1024 N  ND2 . ASN A 1 142 ? 17.919  -5.202  23.633  1.00 34.47  ? 137 ASN L ND2 1 
ATOM   1025 N  N   . LYS A 1 143 ? 12.255  -5.410  24.210  1.00 20.44  ? 138 LYS L N   1 
ATOM   1026 C  CA  . LYS A 1 143 ? 11.330  -6.359  24.843  1.00 21.53  ? 138 LYS L CA  1 
ATOM   1027 C  C   . LYS A 1 143 ? 10.889  -5.976  26.264  1.00 21.25  ? 138 LYS L C   1 
ATOM   1028 O  O   . LYS A 1 143 ? 11.299  -6.599  27.255  1.00 25.17  ? 138 LYS L O   1 
ATOM   1029 C  CB  . LYS A 1 143 ? 11.960  -7.755  24.814  1.00 24.11  ? 138 LYS L CB  1 
ATOM   1030 C  CG  . LYS A 1 143 ? 11.061  -8.913  25.229  1.00 22.14  ? 138 LYS L CG  1 
ATOM   1031 C  CD  . LYS A 1 143 ? 11.817  -10.223 24.984  1.00 34.13  ? 138 LYS L CD  1 
ATOM   1032 C  CE  . LYS A 1 143 ? 11.136  -11.422 25.615  1.00 47.01  ? 138 LYS L CE  1 
ATOM   1033 N  NZ  . LYS A 1 143 ? 9.942   -11.834 24.818  1.00 50.44  ? 138 LYS L NZ  1 
ATOM   1034 N  N   . TYR A 1 144 ? 10.062  -4.944  26.372  1.00 19.16  ? 139 TYR L N   1 
ATOM   1035 C  CA  . TYR A 1 144 ? 9.671   -4.451  27.695  1.00 19.30  ? 139 TYR L CA  1 
ATOM   1036 C  C   . TYR A 1 144 ? 8.173   -4.177  27.791  1.00 23.42  ? 139 TYR L C   1 
ATOM   1037 O  O   . TYR A 1 144 ? 7.494   -4.022  26.775  1.00 18.23  ? 139 TYR L O   1 
ATOM   1038 C  CB  . TYR A 1 144 ? 10.444  -3.169  28.030  1.00 18.96  ? 139 TYR L CB  1 
ATOM   1039 C  CG  . TYR A 1 144 ? 10.111  -2.013  27.103  1.00 19.77  ? 139 TYR L CG  1 
ATOM   1040 C  CD1 . TYR A 1 144 ? 9.027   -1.176  27.362  1.00 20.39  ? 139 TYR L CD1 1 
ATOM   1041 C  CD2 . TYR A 1 144 ? 10.869  -1.768  25.960  1.00 16.99  ? 139 TYR L CD2 1 
ATOM   1042 C  CE1 . TYR A 1 144 ? 8.713   -0.122  26.519  1.00 17.53  ? 139 TYR L CE1 1 
ATOM   1043 C  CE2 . TYR A 1 144 ? 10.560  -0.713  25.108  1.00 16.94  ? 139 TYR L CE2 1 
ATOM   1044 C  CZ  . TYR A 1 144 ? 9.482   0.106   25.394  1.00 19.36  ? 139 TYR L CZ  1 
ATOM   1045 O  OH  . TYR A 1 144 ? 9.154   1.148   24.555  1.00 17.29  ? 139 TYR L OH  1 
ATOM   1046 N  N   . PHE A 1 145 ? 7.678   -4.110  29.022  1.00 18.52  ? 140 PHE L N   1 
ATOM   1047 C  CA  . PHE A 1 145 ? 6.323   -3.653  29.303  1.00 19.41  ? 140 PHE L CA  1 
ATOM   1048 C  C   . PHE A 1 145 ? 6.278   -3.402  30.799  1.00 21.99  ? 140 PHE L C   1 
ATOM   1049 O  O   . PHE A 1 145 ? 6.835   -4.190  31.567  1.00 24.19  ? 140 PHE L O   1 
ATOM   1050 C  CB  . PHE A 1 145 ? 5.274   -4.707  28.932  1.00 19.09  ? 140 PHE L CB  1 
ATOM   1051 C  CG  . PHE A 1 145 ? 3.864   -4.192  29.014  1.00 21.94  ? 140 PHE L CG  1 
ATOM   1052 C  CD1 . PHE A 1 145 ? 3.251   -3.625  27.906  1.00 21.72  ? 140 PHE L CD1 1 
ATOM   1053 C  CD2 . PHE A 1 145 ? 3.160   -4.241  30.206  1.00 23.89  ? 140 PHE L CD2 1 
ATOM   1054 C  CE1 . PHE A 1 145 ? 1.952   -3.133  27.987  1.00 23.30  ? 140 PHE L CE1 1 
ATOM   1055 C  CE2 . PHE A 1 145 ? 1.869   -3.739  30.288  1.00 20.03  ? 140 PHE L CE2 1 
ATOM   1056 C  CZ  . PHE A 1 145 ? 1.267   -3.188  29.177  1.00 22.35  ? 140 PHE L CZ  1 
ATOM   1057 N  N   . PRO A 1 146 ? 5.619   -2.316  31.237  1.00 24.21  ? 141 PRO L N   1 
ATOM   1058 C  CA  . PRO A 1 146 ? 4.898   -1.271  30.494  1.00 22.71  ? 141 PRO L CA  1 
ATOM   1059 C  C   . PRO A 1 146 ? 5.848   -0.235  29.918  1.00 23.37  ? 141 PRO L C   1 
ATOM   1060 O  O   . PRO A 1 146 ? 7.067   -0.464  29.932  1.00 20.90  ? 141 PRO L O   1 
ATOM   1061 C  CB  . PRO A 1 146 ? 4.028   -0.632  31.575  1.00 20.91  ? 141 PRO L CB  1 
ATOM   1062 C  CG  . PRO A 1 146 ? 4.907   -0.730  32.813  1.00 26.72  ? 141 PRO L CG  1 
ATOM   1063 C  CD  . PRO A 1 146 ? 5.542   -2.097  32.698  1.00 24.72  ? 141 PRO L CD  1 
ATOM   1064 N  N   . ASP A 1 147 ? 5.302   0.888   29.441  1.00 19.49  ? 142 ASP L N   1 
ATOM   1065 C  CA  . ASP A 1 147 ? 6.082   1.930   28.778  1.00 19.50  ? 142 ASP L CA  1 
ATOM   1066 C  C   . ASP A 1 147 ? 7.271   2.449   29.611  1.00 27.89  ? 142 ASP L C   1 
ATOM   1067 O  O   . ASP A 1 147 ? 7.254   2.392   30.849  1.00 23.95  ? 142 ASP L O   1 
ATOM   1068 C  CB  . ASP A 1 147 ? 5.181   3.100   28.376  1.00 25.72  ? 142 ASP L CB  1 
ATOM   1069 C  CG  . ASP A 1 147 ? 4.384   2.819   27.105  1.00 29.10  ? 142 ASP L CG  1 
ATOM   1070 O  OD1 . ASP A 1 147 ? 4.994   2.482   26.073  1.00 23.66  ? 142 ASP L OD1 1 
ATOM   1071 O  OD2 . ASP A 1 147 ? 3.141   2.930   27.144  1.00 31.00  ? 142 ASP L OD2 1 
ATOM   1072 N  N   . VAL A 1 148 ? 8.295   2.951   28.920  1.00 21.90  ? 143 VAL L N   1 
ATOM   1073 C  CA  . VAL A 1 148 ? 9.481   3.513   29.557  1.00 17.86  ? 143 VAL L CA  1 
ATOM   1074 C  C   . VAL A 1 148 ? 9.625   4.976   29.173  1.00 26.10  ? 143 VAL L C   1 
ATOM   1075 O  O   . VAL A 1 148 ? 8.930   5.459   28.275  1.00 22.57  ? 143 VAL L O   1 
ATOM   1076 C  CB  . VAL A 1 148 ? 10.783  2.793   29.095  1.00 19.79  ? 143 VAL L CB  1 
ATOM   1077 C  CG1 . VAL A 1 148 ? 10.782  1.326   29.522  1.00 23.12  ? 143 VAL L CG1 1 
ATOM   1078 C  CG2 . VAL A 1 148 ? 10.962  2.915   27.603  1.00 16.11  ? 143 VAL L CG2 1 
ATOM   1079 N  N   . THR A 1 149 ? 10.529  5.680   29.850  1.00 23.85  ? 144 THR L N   1 
ATOM   1080 C  CA  . THR A 1 149 ? 10.943  7.009   29.405  1.00 26.10  ? 144 THR L CA  1 
ATOM   1081 C  C   . THR A 1 149 ? 12.437  6.962   29.122  1.00 26.15  ? 144 THR L C   1 
ATOM   1082 O  O   . THR A 1 149 ? 13.158  6.183   29.740  1.00 26.51  ? 144 THR L O   1 
ATOM   1083 C  CB  . THR A 1 149 ? 10.666  8.091   30.468  1.00 25.81  ? 144 THR L CB  1 
ATOM   1084 O  OG1 . THR A 1 149 ? 11.263  7.692   31.698  1.00 34.75  ? 144 THR L OG1 1 
ATOM   1085 C  CG2 . THR A 1 149 ? 9.157   8.257   30.687  1.00 34.12  ? 144 THR L CG2 1 
ATOM   1086 N  N   . VAL A 1 150 ? 12.899  7.775   28.179  1.00 23.05  ? 145 VAL L N   1 
ATOM   1087 C  CA  . VAL A 1 150 ? 14.312  7.788   27.822  1.00 27.86  ? 145 VAL L CA  1 
ATOM   1088 C  C   . VAL A 1 150 ? 14.922  9.148   28.117  1.00 34.11  ? 145 VAL L C   1 
ATOM   1089 O  O   . VAL A 1 150 ? 14.323  10.170  27.796  1.00 31.64  ? 145 VAL L O   1 
ATOM   1090 C  CB  . VAL A 1 150 ? 14.518  7.504   26.326  1.00 29.40  ? 145 VAL L CB  1 
ATOM   1091 C  CG1 . VAL A 1 150 ? 16.010  7.436   25.993  1.00 24.39  ? 145 VAL L CG1 1 
ATOM   1092 C  CG2 . VAL A 1 150 ? 13.853  6.218   25.944  1.00 31.69  ? 145 VAL L CG2 1 
ATOM   1093 N  N   . THR A 1 151 ? 16.115  9.148   28.716  1.00 32.03  ? 146 THR L N   1 
ATOM   1094 C  CA  . THR A 1 151 ? 16.863  10.376  28.986  1.00 34.16  ? 146 THR L CA  1 
ATOM   1095 C  C   . THR A 1 151 ? 18.248  10.288  28.359  1.00 32.58  ? 146 THR L C   1 
ATOM   1096 O  O   . THR A 1 151 ? 18.965  9.302   28.567  1.00 31.55  ? 146 THR L O   1 
ATOM   1097 C  CB  . THR A 1 151 ? 17.050  10.601  30.509  1.00 33.40  ? 146 THR L CB  1 
ATOM   1098 O  OG1 . THR A 1 151 ? 15.786  10.897  31.110  1.00 39.76  ? 146 THR L OG1 1 
ATOM   1099 C  CG2 . THR A 1 151 ? 18.019  11.748  30.779  1.00 43.93  ? 146 THR L CG2 1 
ATOM   1100 N  N   . TRP A 1 152 ? 18.616  11.308  27.590  1.00 27.51  ? 147 TRP L N   1 
ATOM   1101 C  CA  . TRP A 1 152 ? 19.954  11.399  27.028  1.00 33.17  ? 147 TRP L CA  1 
ATOM   1102 C  C   . TRP A 1 152 ? 20.784  12.379  27.857  1.00 41.51  ? 147 TRP L C   1 
ATOM   1103 O  O   . TRP A 1 152 ? 20.290  13.434  28.273  1.00 39.74  ? 147 TRP L O   1 
ATOM   1104 C  CB  . TRP A 1 152 ? 19.908  11.860  25.571  1.00 34.24  ? 147 TRP L CB  1 
ATOM   1105 C  CG  . TRP A 1 152 ? 19.499  10.796  24.569  1.00 35.83  ? 147 TRP L CG  1 
ATOM   1106 C  CD1 . TRP A 1 152 ? 18.231  10.513  24.135  1.00 29.46  ? 147 TRP L CD1 1 
ATOM   1107 C  CD2 . TRP A 1 152 ? 20.371  9.899   23.864  1.00 30.79  ? 147 TRP L CD2 1 
ATOM   1108 N  NE1 . TRP A 1 152 ? 18.265  9.495   23.212  1.00 30.04  ? 147 TRP L NE1 1 
ATOM   1109 C  CE2 . TRP A 1 152 ? 19.564  9.100   23.029  1.00 30.60  ? 147 TRP L CE2 1 
ATOM   1110 C  CE3 . TRP A 1 152 ? 21.755  9.692   23.863  1.00 27.82  ? 147 TRP L CE3 1 
ATOM   1111 C  CZ2 . TRP A 1 152 ? 20.096  8.116   22.197  1.00 26.00  ? 147 TRP L CZ2 1 
ATOM   1112 C  CZ3 . TRP A 1 152 ? 22.283  8.714   23.044  1.00 28.25  ? 147 TRP L CZ3 1 
ATOM   1113 C  CH2 . TRP A 1 152 ? 21.459  7.938   22.218  1.00 28.29  ? 147 TRP L CH2 1 
ATOM   1114 N  N   . GLU A 1 153 ? 22.039  12.017  28.106  1.00 35.84  ? 148 GLU L N   1 
ATOM   1115 C  CA  . GLU A 1 153 ? 22.985  12.900  28.790  1.00 38.51  ? 148 GLU L CA  1 
ATOM   1116 C  C   . GLU A 1 153 ? 24.308  12.974  28.034  1.00 37.79  ? 148 GLU L C   1 
ATOM   1117 O  O   . GLU A 1 153 ? 24.843  11.954  27.597  1.00 35.97  ? 148 GLU L O   1 
ATOM   1118 C  CB  . GLU A 1 153 ? 23.247  12.413  30.213  1.00 36.04  ? 148 GLU L CB  1 
ATOM   1119 C  CG  . GLU A 1 153 ? 22.053  12.504  31.140  1.00 49.58  ? 148 GLU L CG  1 
ATOM   1120 C  CD  . GLU A 1 153 ? 22.370  11.959  32.512  1.00 57.87  ? 148 GLU L CD  1 
ATOM   1121 O  OE1 . GLU A 1 153 ? 23.563  11.991  32.888  1.00 66.24  ? 148 GLU L OE1 1 
ATOM   1122 O  OE2 . GLU A 1 153 ? 21.437  11.492  33.206  1.00 56.93  ? 148 GLU L OE2 1 
ATOM   1123 N  N   . VAL A 1 154 ? 24.829  14.187  27.881  1.00 38.05  ? 149 VAL L N   1 
ATOM   1124 C  CA  . VAL A 1 154 ? 26.135  14.393  27.266  1.00 37.78  ? 149 VAL L CA  1 
ATOM   1125 C  C   . VAL A 1 154 ? 27.060  15.074  28.276  1.00 46.97  ? 149 VAL L C   1 
ATOM   1126 O  O   . VAL A 1 154 ? 26.814  16.212  28.680  1.00 44.95  ? 149 VAL L O   1 
ATOM   1127 C  CB  . VAL A 1 154 ? 26.031  15.237  25.979  1.00 40.57  ? 149 VAL L CB  1 
ATOM   1128 C  CG1 . VAL A 1 154 ? 27.412  15.486  25.386  1.00 37.37  ? 149 VAL L CG1 1 
ATOM   1129 C  CG2 . VAL A 1 154 ? 25.135  14.548  24.953  1.00 38.52  ? 149 VAL L CG2 1 
ATOM   1130 N  N   . ASP A 1 155 ? 28.111  14.365  28.679  1.00 43.58  ? 150 ASP L N   1 
ATOM   1131 C  CA  . ASP A 1 155 ? 28.995  14.807  29.753  1.00 42.43  ? 150 ASP L CA  1 
ATOM   1132 C  C   . ASP A 1 155 ? 28.229  15.260  30.993  1.00 49.56  ? 150 ASP L C   1 
ATOM   1133 O  O   . ASP A 1 155 ? 28.577  16.263  31.614  1.00 53.96  ? 150 ASP L O   1 
ATOM   1134 C  CB  . ASP A 1 155 ? 29.939  15.909  29.269  1.00 38.28  ? 150 ASP L CB  1 
ATOM   1135 C  CG  . ASP A 1 155 ? 31.052  15.371  28.396  1.00 42.31  ? 150 ASP L CG  1 
ATOM   1136 O  OD1 . ASP A 1 155 ? 31.446  14.201  28.597  1.00 42.75  ? 150 ASP L OD1 1 
ATOM   1137 O  OD2 . ASP A 1 155 ? 31.527  16.107  27.508  1.00 38.23  ? 150 ASP L OD2 1 
ATOM   1138 N  N   . GLY A 1 156 ? 27.185  14.518  31.349  1.00 47.13  ? 151 GLY L N   1 
ATOM   1139 C  CA  . GLY A 1 156 ? 26.431  14.799  32.563  1.00 47.56  ? 151 GLY L CA  1 
ATOM   1140 C  C   . GLY A 1 156 ? 25.226  15.704  32.369  1.00 45.18  ? 151 GLY L C   1 
ATOM   1141 O  O   . GLY A 1 156 ? 24.340  15.771  33.222  1.00 51.79  ? 151 GLY L O   1 
ATOM   1142 N  N   . THR A 1 157 ? 25.189  16.400  31.240  1.00 44.07  ? 152 THR L N   1 
ATOM   1143 C  CA  . THR A 1 157 ? 24.126  17.361  30.967  1.00 48.01  ? 152 THR L CA  1 
ATOM   1144 C  C   . THR A 1 157 ? 22.957  16.747  30.193  1.00 45.33  ? 152 THR L C   1 
ATOM   1145 O  O   . THR A 1 157 ? 23.136  16.239  29.085  1.00 43.22  ? 152 THR L O   1 
ATOM   1146 C  CB  . THR A 1 157 ? 24.672  18.560  30.176  1.00 48.79  ? 152 THR L CB  1 
ATOM   1147 O  OG1 . THR A 1 157 ? 25.698  19.202  30.942  1.00 54.12  ? 152 THR L OG1 1 
ATOM   1148 C  CG2 . THR A 1 157 ? 23.558  19.557  29.874  1.00 46.79  ? 152 THR L CG2 1 
ATOM   1149 N  N   . THR A 1 158 ? 21.762  16.807  30.777  1.00 44.89  ? 153 THR L N   1 
ATOM   1150 C  CA  . THR A 1 158 ? 20.559  16.287  30.126  1.00 43.30  ? 153 THR L CA  1 
ATOM   1151 C  C   . THR A 1 158 ? 20.243  17.032  28.831  1.00 46.61  ? 153 THR L C   1 
ATOM   1152 O  O   . THR A 1 158 ? 20.177  18.261  28.820  1.00 47.55  ? 153 THR L O   1 
ATOM   1153 C  CB  . THR A 1 158 ? 19.349  16.371  31.058  1.00 44.23  ? 153 THR L CB  1 
ATOM   1154 O  OG1 . THR A 1 158 ? 19.565  15.516  32.187  1.00 45.88  ? 153 THR L OG1 1 
ATOM   1155 C  CG2 . THR A 1 158 ? 18.071  15.943  30.331  1.00 42.46  ? 153 THR L CG2 1 
ATOM   1156 N  N   . GLN A 1 159 ? 20.062  16.283  27.743  1.00 42.55  ? 154 GLN L N   1 
ATOM   1157 C  CA  . GLN A 1 159 ? 19.711  16.857  26.448  1.00 33.82  ? 154 GLN L CA  1 
ATOM   1158 C  C   . GLN A 1 159 ? 18.225  17.144  26.379  1.00 42.16  ? 154 GLN L C   1 
ATOM   1159 O  O   . GLN A 1 159 ? 17.412  16.394  26.925  1.00 40.67  ? 154 GLN L O   1 
ATOM   1160 C  CB  . GLN A 1 159 ? 20.089  15.899  25.319  1.00 38.29  ? 154 GLN L CB  1 
ATOM   1161 C  CG  . GLN A 1 159 ? 21.572  15.580  25.259  1.00 33.91  ? 154 GLN L CG  1 
ATOM   1162 C  CD  . GLN A 1 159 ? 22.405  16.827  25.047  1.00 37.76  ? 154 GLN L CD  1 
ATOM   1163 O  OE1 . GLN A 1 159 ? 22.490  17.342  23.934  1.00 34.60  ? 154 GLN L OE1 1 
ATOM   1164 N  NE2 . GLN A 1 159 ? 22.999  17.333  26.120  1.00 40.15  ? 154 GLN L NE2 1 
ATOM   1165 N  N   . THR A 1 160 ? 17.866  18.218  25.685  1.00 37.01  ? 155 THR L N   1 
ATOM   1166 C  CA  . THR A 1 160 ? 16.472  18.641  25.625  1.00 45.73  ? 155 THR L CA  1 
ATOM   1167 C  C   . THR A 1 160 ? 16.015  18.855  24.189  1.00 48.55  ? 155 THR L C   1 
ATOM   1168 O  O   . THR A 1 160 ? 14.866  19.226  23.945  1.00 44.35  ? 155 THR L O   1 
ATOM   1169 C  CB  . THR A 1 160 ? 16.231  19.934  26.441  1.00 45.93  ? 155 THR L CB  1 
ATOM   1170 O  OG1 . THR A 1 160 ? 17.210  20.918  26.086  1.00 43.59  ? 155 THR L OG1 1 
ATOM   1171 C  CG2 . THR A 1 160 ? 16.343  19.652  27.928  1.00 48.57  ? 155 THR L CG2 1 
ATOM   1172 N  N   . THR A 1 161 ? 16.917  18.606  23.243  1.00 35.57  ? 156 THR L N   1 
ATOM   1173 C  CA  . THR A 1 161 ? 16.613  18.790  21.831  1.00 33.56  ? 156 THR L CA  1 
ATOM   1174 C  C   . THR A 1 161 ? 17.375  17.777  20.952  1.00 35.92  ? 156 THR L C   1 
ATOM   1175 O  O   . THR A 1 161 ? 18.349  17.166  21.399  1.00 36.64  ? 156 THR L O   1 
ATOM   1176 C  CB  . THR A 1 161 ? 16.949  20.225  21.386  1.00 44.57  ? 156 THR L CB  1 
ATOM   1177 O  OG1 . THR A 1 161 ? 16.395  20.479  20.087  1.00 48.00  ? 156 THR L OG1 1 
ATOM   1178 C  CG2 . THR A 1 161 ? 18.457  20.430  21.355  1.00 37.42  ? 156 THR L CG2 1 
ATOM   1179 N  N   . GLY A 1 162 ? 16.927  17.604  19.710  1.00 26.73  ? 157 GLY L N   1 
ATOM   1180 C  CA  . GLY A 1 162 ? 17.553  16.668  18.788  1.00 31.69  ? 157 GLY L CA  1 
ATOM   1181 C  C   . GLY A 1 162 ? 17.197  15.196  19.008  1.00 34.21  ? 157 GLY L C   1 
ATOM   1182 O  O   . GLY A 1 162 ? 17.870  14.310  18.494  1.00 31.35  ? 157 GLY L O   1 
ATOM   1183 N  N   . ILE A 1 163 ? 16.128  14.925  19.750  1.00 31.77  ? 158 ILE L N   1 
ATOM   1184 C  CA  . ILE A 1 163 ? 15.771  13.549  20.083  1.00 26.95  ? 158 ILE L CA  1 
ATOM   1185 C  C   . ILE A 1 163 ? 14.499  13.095  19.369  1.00 31.09  ? 158 ILE L C   1 
ATOM   1186 O  O   . ILE A 1 163 ? 13.508  13.820  19.337  1.00 33.31  ? 158 ILE L O   1 
ATOM   1187 C  CB  . ILE A 1 163 ? 15.597  13.387  21.595  1.00 29.86  ? 158 ILE L CB  1 
ATOM   1188 C  CG1 . ILE A 1 163 ? 16.887  13.787  22.314  1.00 33.14  ? 158 ILE L CG1 1 
ATOM   1189 C  CG2 . ILE A 1 163 ? 15.209  11.961  21.950  1.00 29.70  ? 158 ILE L CG2 1 
ATOM   1190 C  CD1 . ILE A 1 163 ? 16.710  13.956  23.810  1.00 31.56  ? 158 ILE L CD1 1 
ATOM   1191 N  N   . GLU A 1 164 ? 14.543  11.899  18.780  1.00 26.20  ? 159 GLU L N   1 
ATOM   1192 C  CA  . GLU A 1 164 ? 13.360  11.264  18.201  1.00 29.46  ? 159 GLU L CA  1 
ATOM   1193 C  C   . GLU A 1 164 ? 13.186  9.830   18.721  1.00 28.01  ? 159 GLU L C   1 
ATOM   1194 O  O   . GLU A 1 164 ? 14.162  9.092   18.870  1.00 27.77  ? 159 GLU L O   1 
ATOM   1195 C  CB  . GLU A 1 164 ? 13.433  11.259  16.667  1.00 27.55  ? 159 GLU L CB  1 
ATOM   1196 C  CG  . GLU A 1 164 ? 13.506  12.651  16.030  1.00 36.37  ? 159 GLU L CG  1 
ATOM   1197 C  CD  . GLU A 1 164 ? 12.289  13.522  16.335  1.00 42.53  ? 159 GLU L CD  1 
ATOM   1198 O  OE1 . GLU A 1 164 ? 11.233  12.983  16.738  1.00 37.26  ? 159 GLU L OE1 1 
ATOM   1199 O  OE2 . GLU A 1 164 ? 12.387  14.756  16.160  1.00 43.96  ? 159 GLU L OE2 1 
ATOM   1200 N  N   . ASN A 1 165 ? 11.942  9.448   18.998  1.00 28.23  ? 160 ASN L N   1 
ATOM   1201 C  CA  . ASN A 1 165 ? 11.627  8.107   19.481  1.00 25.03  ? 160 ASN L CA  1 
ATOM   1202 C  C   . ASN A 1 165 ? 10.670  7.387   18.535  1.00 27.40  ? 160 ASN L C   1 
ATOM   1203 O  O   . ASN A 1 165 ? 9.750   8.000   17.976  1.00 23.17  ? 160 ASN L O   1 
ATOM   1204 C  CB  . ASN A 1 165 ? 11.017  8.169   20.893  1.00 26.77  ? 160 ASN L CB  1 
ATOM   1205 C  CG  . ASN A 1 165 ? 11.989  8.728   21.932  1.00 34.68  ? 160 ASN L CG  1 
ATOM   1206 O  OD1 . ASN A 1 165 ? 13.200  8.584   21.803  1.00 30.08  ? 160 ASN L OD1 1 
ATOM   1207 N  ND2 . ASN A 1 165 ? 11.455  9.359   22.969  1.00 32.84  ? 160 ASN L ND2 1 
ATOM   1208 N  N   . SER A 1 166 ? 10.892  6.085   18.367  1.00 19.77  ? 161 SER L N   1 
ATOM   1209 C  CA  . SER A 1 166 ? 10.029  5.248   17.563  1.00 22.36  ? 161 SER L CA  1 
ATOM   1210 C  C   . SER A 1 166 ? 9.785   3.896   18.259  1.00 26.26  ? 161 SER L C   1 
ATOM   1211 O  O   . SER A 1 166 ? 10.728  3.207   18.615  1.00 19.22  ? 161 SER L O   1 
ATOM   1212 C  CB  . SER A 1 166 ? 10.650  5.037   16.194  1.00 25.08  ? 161 SER L CB  1 
ATOM   1213 O  OG  . SER A 1 166 ? 9.785   4.258   15.399  1.00 30.34  ? 161 SER L OG  1 
ATOM   1214 N  N   . LYS A 1 167 ? 8.515   3.542   18.457  1.00 23.04  ? 162 LYS L N   1 
ATOM   1215 C  CA  . LYS A 1 167 ? 8.117   2.334   19.193  1.00 22.74  ? 162 LYS L CA  1 
ATOM   1216 C  C   . LYS A 1 167 ? 7.408   1.304   18.286  1.00 25.38  ? 162 LYS L C   1 
ATOM   1217 O  O   . LYS A 1 167 ? 6.554   1.668   17.474  1.00 26.21  ? 162 LYS L O   1 
ATOM   1218 C  CB  . LYS A 1 167 ? 7.210   2.747   20.364  1.00 21.85  ? 162 LYS L CB  1 
ATOM   1219 C  CG  . LYS A 1 167 ? 6.974   1.665   21.404  1.00 21.90  ? 162 LYS L CG  1 
ATOM   1220 C  CD  . LYS A 1 167 ? 6.294   2.226   22.649  1.00 24.22  ? 162 LYS L CD  1 
ATOM   1221 C  CE  . LYS A 1 167 ? 4.838   2.613   22.379  1.00 27.71  ? 162 LYS L CE  1 
ATOM   1222 N  NZ  . LYS A 1 167 ? 4.183   3.170   23.607  1.00 24.33  ? 162 LYS L NZ  1 
ATOM   1223 N  N   . THR A 1 168 ? 7.773   0.026   18.403  1.00 18.54  ? 163 THR L N   1 
ATOM   1224 C  CA  . THR A 1 168 ? 7.151   -1.038  17.602  1.00 22.67  ? 163 THR L CA  1 
ATOM   1225 C  C   . THR A 1 168 ? 5.728   -1.339  18.087  1.00 25.01  ? 163 THR L C   1 
ATOM   1226 O  O   . THR A 1 168 ? 5.352   -0.897  19.170  1.00 22.43  ? 163 THR L O   1 
ATOM   1227 C  CB  . THR A 1 168 ? 7.958   -2.353  17.682  1.00 23.95  ? 163 THR L CB  1 
ATOM   1228 O  OG1 . THR A 1 168 ? 7.979   -2.824  19.038  1.00 26.97  ? 163 THR L OG1 1 
ATOM   1229 C  CG2 . THR A 1 168 ? 9.398   -2.151  17.169  1.00 21.64  ? 163 THR L CG2 1 
ATOM   1230 N  N   . PRO A 1 169 ? 4.928   -2.077  17.286  1.00 24.28  ? 164 PRO L N   1 
ATOM   1231 C  CA  . PRO A 1 169 ? 3.644   -2.583  17.817  1.00 25.09  ? 164 PRO L CA  1 
ATOM   1232 C  C   . PRO A 1 169 ? 3.878   -3.618  18.921  1.00 28.42  ? 164 PRO L C   1 
ATOM   1233 O  O   . PRO A 1 169 ? 4.981   -4.155  19.025  1.00 25.05  ? 164 PRO L O   1 
ATOM   1234 C  CB  . PRO A 1 169 ? 2.992   -3.256  16.596  1.00 23.17  ? 164 PRO L CB  1 
ATOM   1235 C  CG  . PRO A 1 169 ? 3.630   -2.605  15.415  1.00 28.00  ? 164 PRO L CG  1 
ATOM   1236 C  CD  . PRO A 1 169 ? 5.055   -2.320  15.837  1.00 24.93  ? 164 PRO L CD  1 
ATOM   1237 N  N   . GLN A 1 170 ? 2.866   -3.884  19.741  1.00 20.21  ? 165 GLN L N   1 
ATOM   1238 C  CA  . GLN A 1 170 ? 2.983   -4.886  20.805  1.00 15.96  ? 165 GLN L CA  1 
ATOM   1239 C  C   . GLN A 1 170 ? 3.226   -6.283  20.244  1.00 21.19  ? 165 GLN L C   1 
ATOM   1240 O  O   . GLN A 1 170 ? 2.611   -6.672  19.249  1.00 23.61  ? 165 GLN L O   1 
ATOM   1241 C  CB  . GLN A 1 170 ? 1.710   -4.907  21.673  1.00 16.41  ? 165 GLN L CB  1 
ATOM   1242 C  CG  . GLN A 1 170 ? 1.458   -3.600  22.463  1.00 18.74  ? 165 GLN L CG  1 
ATOM   1243 C  CD  . GLN A 1 170 ? 0.332   -3.721  23.478  1.00 20.15  ? 165 GLN L CD  1 
ATOM   1244 O  OE1 . GLN A 1 170 ? -0.800  -3.319  23.210  1.00 18.01  ? 165 GLN L OE1 1 
ATOM   1245 N  NE2 . GLN A 1 170 ? 0.636   -4.292  24.648  1.00 19.97  ? 165 GLN L NE2 1 
ATOM   1246 N  N   . ASN A 1 171 ? 4.109   -7.038  20.896  1.00 22.07  ? 166 ASN L N   1 
ATOM   1247 C  CA  . ASN A 1 171 ? 4.369   -8.426  20.529  1.00 22.77  ? 166 ASN L CA  1 
ATOM   1248 C  C   . ASN A 1 171 ? 3.116   -9.265  20.706  1.00 26.94  ? 166 ASN L C   1 
ATOM   1249 O  O   . ASN A 1 171 ? 2.470   -9.195  21.742  1.00 23.72  ? 166 ASN L O   1 
ATOM   1250 C  CB  . ASN A 1 171 ? 5.496   -9.004  21.383  1.00 21.82  ? 166 ASN L CB  1 
ATOM   1251 C  CG  . ASN A 1 171 ? 5.896   -10.407 20.951  1.00 32.48  ? 166 ASN L CG  1 
ATOM   1252 O  OD1 . ASN A 1 171 ? 5.325   -11.390 21.414  1.00 29.02  ? 166 ASN L OD1 1 
ATOM   1253 N  ND2 . ASN A 1 171 ? 6.886   -10.503 20.070  1.00 29.06  ? 166 ASN L ND2 1 
ATOM   1254 N  N   . SER A 1 172 ? 2.778   -10.072 19.704  1.00 29.71  ? 167 SER L N   1 
ATOM   1255 C  CA  . SER A 1 172 ? 1.538   -10.842 19.743  1.00 23.83  ? 167 SER L CA  1 
ATOM   1256 C  C   . SER A 1 172 ? 1.576   -11.964 20.771  1.00 26.55  ? 167 SER L C   1 
ATOM   1257 O  O   . SER A 1 172 ? 0.529   -12.496 21.139  1.00 32.47  ? 167 SER L O   1 
ATOM   1258 C  CB  . SER A 1 172 ? 1.189   -11.398 18.359  1.00 30.70  ? 167 SER L CB  1 
ATOM   1259 O  OG  . SER A 1 172 ? 2.132   -12.382 17.963  1.00 47.03  ? 167 SER L OG  1 
ATOM   1260 N  N   . ALA A 1 173 ? 2.770   -12.317 21.243  1.00 22.68  ? 168 ALA L N   1 
ATOM   1261 C  CA  . ALA A 1 173 ? 2.896   -13.370 22.249  1.00 31.49  ? 168 ALA L CA  1 
ATOM   1262 C  C   . ALA A 1 173 ? 2.890   -12.885 23.700  1.00 31.33  ? 168 ALA L C   1 
ATOM   1263 O  O   . ALA A 1 173 ? 2.269   -13.519 24.552  1.00 33.95  ? 168 ALA L O   1 
ATOM   1264 C  CB  . ALA A 1 173 ? 4.132   -14.243 21.984  1.00 32.27  ? 168 ALA L CB  1 
ATOM   1265 N  N   . ASP A 1 174 ? 3.571   -11.779 23.989  1.00 23.05  ? 169 ASP L N   1 
ATOM   1266 C  CA  . ASP A 1 174 ? 3.755   -11.351 25.386  1.00 23.77  ? 169 ASP L CA  1 
ATOM   1267 C  C   . ASP A 1 174 ? 3.471   -9.863  25.648  1.00 23.66  ? 169 ASP L C   1 
ATOM   1268 O  O   . ASP A 1 174 ? 3.790   -9.351  26.721  1.00 20.59  ? 169 ASP L O   1 
ATOM   1269 C  CB  . ASP A 1 174 ? 5.156   -11.726 25.911  1.00 22.15  ? 169 ASP L CB  1 
ATOM   1270 C  CG  . ASP A 1 174 ? 6.292   -10.997 25.181  1.00 30.12  ? 169 ASP L CG  1 
ATOM   1271 O  OD1 . ASP A 1 174 ? 7.468   -11.373 25.396  1.00 29.34  ? 169 ASP L OD1 1 
ATOM   1272 O  OD2 . ASP A 1 174 ? 6.019   -10.057 24.401  1.00 22.51  ? 169 ASP L OD2 1 
ATOM   1273 N  N   . CYS A 1 175 ? 2.890   -9.179  24.666  1.00 17.95  ? 170 CYS L N   1 
ATOM   1274 C  CA  . CYS A 1 175 ? 2.514   -7.765  24.811  1.00 19.29  ? 170 CYS L CA  1 
ATOM   1275 C  C   . CYS A 1 175 ? 3.690   -6.756  24.835  1.00 19.76  ? 170 CYS L C   1 
ATOM   1276 O  O   . CYS A 1 175 ? 3.437   -5.552  24.903  1.00 19.06  ? 170 CYS L O   1 
ATOM   1277 C  CB  . CYS A 1 175 ? 1.596   -7.549  26.040  1.00 17.04  ? 170 CYS L CB  1 
ATOM   1278 S  SG  . CYS A 1 175 ? -0.115  -8.250  25.949  1.00 24.00  ? 170 CYS L SG  1 
ATOM   1279 N  N   . THR A 1 176 ? 4.949   -7.216  24.759  1.00 16.21  ? 171 THR L N   1 
ATOM   1280 C  CA  . THR A 1 176 ? 6.089   -6.297  24.910  1.00 19.11  ? 171 THR L CA  1 
ATOM   1281 C  C   . THR A 1 176 ? 6.284   -5.361  23.724  1.00 19.25  ? 171 THR L C   1 
ATOM   1282 O  O   . THR A 1 176 ? 5.878   -5.669  22.601  1.00 20.14  ? 171 THR L O   1 
ATOM   1283 C  CB  . THR A 1 176 ? 7.424   -7.024  25.199  1.00 17.53  ? 171 THR L CB  1 
ATOM   1284 O  OG1 . THR A 1 176 ? 7.667   -8.012  24.178  1.00 19.80  ? 171 THR L OG1 1 
ATOM   1285 C  CG2 . THR A 1 176 ? 7.379   -7.705  26.556  1.00 20.93  ? 171 THR L CG2 1 
ATOM   1286 N  N   . TYR A 1 177 ? 6.901   -4.216  24.009  1.00 21.47  ? 172 TYR L N   1 
ATOM   1287 C  CA  . TYR A 1 177 ? 7.313   -3.219  23.025  1.00 19.02  ? 172 TYR L CA  1 
ATOM   1288 C  C   . TYR A 1 177 ? 8.814   -3.311  22.785  1.00 19.92  ? 172 TYR L C   1 
ATOM   1289 O  O   . TYR A 1 177 ? 9.541   -3.905  23.584  1.00 17.02  ? 172 TYR L O   1 
ATOM   1290 C  CB  . TYR A 1 177 ? 7.057   -1.808  23.585  1.00 16.92  ? 172 TYR L CB  1 
ATOM   1291 C  CG  . TYR A 1 177 ? 5.606   -1.425  23.738  1.00 18.68  ? 172 TYR L CG  1 
ATOM   1292 C  CD1 . TYR A 1 177 ? 5.050   -1.215  24.990  1.00 19.94  ? 172 TYR L CD1 1 
ATOM   1293 C  CD2 . TYR A 1 177 ? 4.790   -1.282  22.621  1.00 16.98  ? 172 TYR L CD2 1 
ATOM   1294 C  CE1 . TYR A 1 177 ? 3.712   -0.846  25.128  1.00 19.54  ? 172 TYR L CE1 1 
ATOM   1295 C  CE2 . TYR A 1 177 ? 3.466   -0.921  22.749  1.00 16.91  ? 172 TYR L CE2 1 
ATOM   1296 C  CZ  . TYR A 1 177 ? 2.933   -0.710  23.994  1.00 19.59  ? 172 TYR L CZ  1 
ATOM   1297 O  OH  . TYR A 1 177 ? 1.610   -0.360  24.100  1.00 24.08  ? 172 TYR L OH  1 
ATOM   1298 N  N   . ASN A 1 178 ? 9.269   -2.699  21.693  1.00 17.74  ? 173 ASN L N   1 
ATOM   1299 C  CA  . ASN A 1 178 ? 10.670  -2.331  21.527  1.00 17.21  ? 173 ASN L CA  1 
ATOM   1300 C  C   . ASN A 1 178 ? 10.722  -0.850  21.139  1.00 20.30  ? 173 ASN L C   1 
ATOM   1301 O  O   . ASN A 1 178 ? 9.784   -0.334  20.543  1.00 17.58  ? 173 ASN L O   1 
ATOM   1302 C  CB  . ASN A 1 178 ? 11.356  -3.172  20.461  1.00 16.45  ? 173 ASN L CB  1 
ATOM   1303 C  CG  . ASN A 1 178 ? 11.231  -4.649  20.722  1.00 22.55  ? 173 ASN L CG  1 
ATOM   1304 O  OD1 . ASN A 1 178 ? 12.059  -5.241  21.403  1.00 17.04  ? 173 ASN L OD1 1 
ATOM   1305 N  ND2 . ASN A 1 178 ? 10.185  -5.257  20.177  1.00 21.18  ? 173 ASN L ND2 1 
ATOM   1306 N  N   . LEU A 1 179 ? 11.808  -0.170  21.493  1.00 16.59  ? 174 LEU L N   1 
ATOM   1307 C  CA  . LEU A 1 179 ? 11.923  1.270   21.249  1.00 18.83  ? 174 LEU L CA  1 
ATOM   1308 C  C   . LEU A 1 179 ? 13.288  1.640   20.700  1.00 21.91  ? 174 LEU L C   1 
ATOM   1309 O  O   . LEU A 1 179 ? 14.313  1.151   21.191  1.00 20.73  ? 174 LEU L O   1 
ATOM   1310 C  CB  . LEU A 1 179 ? 11.708  2.047   22.547  1.00 19.59  ? 174 LEU L CB  1 
ATOM   1311 C  CG  . LEU A 1 179 ? 11.721  3.572   22.419  1.00 27.11  ? 174 LEU L CG  1 
ATOM   1312 C  CD1 . LEU A 1 179 ? 10.413  4.070   21.864  1.00 27.24  ? 174 LEU L CD1 1 
ATOM   1313 C  CD2 . LEU A 1 179 ? 11.990  4.220   23.753  1.00 33.99  ? 174 LEU L CD2 1 
ATOM   1314 N  N   . SER A 1 180 ? 13.308  2.517   19.699  1.00 14.88  ? 175 SER L N   1 
ATOM   1315 C  CA  . SER A 1 180 ? 14.562  3.120   19.263  1.00 20.30  ? 175 SER L CA  1 
ATOM   1316 C  C   . SER A 1 180 ? 14.524  4.609   19.585  1.00 24.62  ? 175 SER L C   1 
ATOM   1317 O  O   . SER A 1 180 ? 13.548  5.292   19.277  1.00 27.37  ? 175 SER L O   1 
ATOM   1318 C  CB  . SER A 1 180 ? 14.762  2.938   17.766  1.00 24.04  ? 175 SER L CB  1 
ATOM   1319 O  OG  . SER A 1 180 ? 13.908  3.808   17.048  1.00 29.91  ? 175 SER L OG  1 
ATOM   1320 N  N   . SER A 1 181 ? 15.575  5.110   20.219  1.00 24.51  ? 176 SER L N   1 
ATOM   1321 C  CA  . SER A 1 181 ? 15.696  6.544   20.479  1.00 22.42  ? 176 SER L CA  1 
ATOM   1322 C  C   . SER A 1 181 ? 16.988  7.053   19.828  1.00 31.80  ? 176 SER L C   1 
ATOM   1323 O  O   . SER A 1 181 ? 18.046  6.446   19.988  1.00 28.92  ? 176 SER L O   1 
ATOM   1324 C  CB  . SER A 1 181 ? 15.710  6.816   21.984  1.00 22.78  ? 176 SER L CB  1 
ATOM   1325 O  OG  . SER A 1 181 ? 15.792  8.220   22.260  1.00 23.62  ? 176 SER L OG  1 
ATOM   1326 N  N   . THR A 1 182 ? 16.906  8.147   19.078  1.00 24.04  ? 177 THR L N   1 
ATOM   1327 C  CA  . THR A 1 182 ? 18.085  8.696   18.419  1.00 26.19  ? 177 THR L CA  1 
ATOM   1328 C  C   . THR A 1 182 ? 18.383  10.115  18.885  1.00 31.81  ? 177 THR L C   1 
ATOM   1329 O  O   . THR A 1 182 ? 17.469  10.921  19.052  1.00 31.96  ? 177 THR L O   1 
ATOM   1330 C  CB  . THR A 1 182 ? 17.927  8.716   16.893  1.00 30.08  ? 177 THR L CB  1 
ATOM   1331 O  OG1 . THR A 1 182 ? 16.856  9.599   16.538  1.00 29.62  ? 177 THR L OG1 1 
ATOM   1332 C  CG2 . THR A 1 182 ? 17.619  7.317   16.372  1.00 24.40  ? 177 THR L CG2 1 
ATOM   1333 N  N   . LEU A 1 183 ? 19.664  10.399  19.107  1.00 25.48  ? 178 LEU L N   1 
ATOM   1334 C  CA  . LEU A 1 183 ? 20.137  11.748  19.400  1.00 23.09  ? 178 LEU L CA  1 
ATOM   1335 C  C   . LEU A 1 183 ? 20.968  12.261  18.239  1.00 32.61  ? 178 LEU L C   1 
ATOM   1336 O  O   . LEU A 1 183 ? 21.945  11.617  17.832  1.00 28.96  ? 178 LEU L O   1 
ATOM   1337 C  CB  . LEU A 1 183 ? 20.982  11.769  20.678  1.00 26.90  ? 178 LEU L CB  1 
ATOM   1338 C  CG  . LEU A 1 183 ? 21.612  13.120  21.051  1.00 29.17  ? 178 LEU L CG  1 
ATOM   1339 C  CD1 . LEU A 1 183 ? 20.548  14.157  21.374  1.00 28.92  ? 178 LEU L CD1 1 
ATOM   1340 C  CD2 . LEU A 1 183 ? 22.559  12.963  22.223  1.00 28.23  ? 178 LEU L CD2 1 
ATOM   1341 N  N   . THR A 1 184 ? 20.583  13.420  17.705  1.00 26.06  ? 179 THR L N   1 
ATOM   1342 C  CA  . THR A 1 184 ? 21.260  13.992  16.546  1.00 28.92  ? 179 THR L CA  1 
ATOM   1343 C  C   . THR A 1 184 ? 21.966  15.302  16.891  1.00 32.30  ? 179 THR L C   1 
ATOM   1344 O  O   . THR A 1 184 ? 21.367  16.185  17.504  1.00 30.01  ? 179 THR L O   1 
ATOM   1345 C  CB  . THR A 1 184 ? 20.269  14.221  15.399  1.00 33.21  ? 179 THR L CB  1 
ATOM   1346 O  OG1 . THR A 1 184 ? 19.635  12.976  15.078  1.00 35.75  ? 179 THR L OG1 1 
ATOM   1347 C  CG2 . THR A 1 184 ? 20.980  14.763  14.170  1.00 31.05  ? 179 THR L CG2 1 
ATOM   1348 N  N   . LEU A 1 185 ? 23.238  15.410  16.495  1.00 36.52  ? 180 LEU L N   1 
ATOM   1349 C  CA  . LEU A 1 185 ? 24.069  16.585  16.770  1.00 33.22  ? 180 LEU L CA  1 
ATOM   1350 C  C   . LEU A 1 185 ? 24.902  16.929  15.543  1.00 40.79  ? 180 LEU L C   1 
ATOM   1351 O  O   . LEU A 1 185 ? 25.060  16.104  14.643  1.00 34.97  ? 180 LEU L O   1 
ATOM   1352 C  CB  . LEU A 1 185 ? 25.040  16.297  17.920  1.00 35.37  ? 180 LEU L CB  1 
ATOM   1353 C  CG  . LEU A 1 185 ? 24.545  15.883  19.307  1.00 39.44  ? 180 LEU L CG  1 
ATOM   1354 C  CD1 . LEU A 1 185 ? 25.727  15.408  20.136  1.00 45.69  ? 180 LEU L CD1 1 
ATOM   1355 C  CD2 . LEU A 1 185 ? 23.830  17.015  20.005  1.00 40.44  ? 180 LEU L CD2 1 
ATOM   1356 N  N   . THR A 1 186 ? 25.450  18.143  15.512  1.00 30.50  ? 181 THR L N   1 
ATOM   1357 C  CA  . THR A 1 186 ? 26.411  18.506  14.484  1.00 40.23  ? 181 THR L CA  1 
ATOM   1358 C  C   . THR A 1 186 ? 27.722  17.809  14.815  1.00 30.88  ? 181 THR L C   1 
ATOM   1359 O  O   . THR A 1 186 ? 27.943  17.416  15.964  1.00 35.26  ? 181 THR L O   1 
ATOM   1360 C  CB  . THR A 1 186 ? 26.664  20.025  14.447  1.00 37.16  ? 181 THR L CB  1 
ATOM   1361 O  OG1 . THR A 1 186 ? 27.348  20.421  15.641  1.00 40.27  ? 181 THR L OG1 1 
ATOM   1362 C  CG2 . THR A 1 186 ? 25.353  20.790  14.347  1.00 37.94  ? 181 THR L CG2 1 
ATOM   1363 N  N   . SER A 1 187 ? 28.580  17.640  13.812  1.00 37.86  ? 182 SER L N   1 
ATOM   1364 C  CA  . SER A 1 187 ? 29.884  17.030  14.041  1.00 37.59  ? 182 SER L CA  1 
ATOM   1365 C  C   . SER A 1 187 ? 30.703  17.883  15.005  1.00 40.74  ? 182 SER L C   1 
ATOM   1366 O  O   . SER A 1 187 ? 31.418  17.366  15.866  1.00 45.36  ? 182 SER L O   1 
ATOM   1367 C  CB  . SER A 1 187 ? 30.625  16.848  12.723  1.00 44.93  ? 182 SER L CB  1 
ATOM   1368 O  OG  . SER A 1 187 ? 29.892  16.001  11.856  1.00 46.72  ? 182 SER L OG  1 
ATOM   1369 N  N   . THR A 1 188 ? 30.570  19.195  14.863  1.00 40.39  ? 183 THR L N   1 
ATOM   1370 C  CA  . THR A 1 188 ? 31.246  20.133  15.747  1.00 43.05  ? 183 THR L CA  1 
ATOM   1371 C  C   . THR A 1 188 ? 30.859  19.870  17.199  1.00 42.66  ? 183 THR L C   1 
ATOM   1372 O  O   . THR A 1 188 ? 31.715  19.727  18.071  1.00 46.69  ? 183 THR L O   1 
ATOM   1373 C  CB  . THR A 1 188 ? 30.905  21.589  15.369  1.00 46.02  ? 183 THR L CB  1 
ATOM   1374 O  OG1 . THR A 1 188 ? 31.416  21.878  14.062  1.00 49.88  ? 183 THR L OG1 1 
ATOM   1375 C  CG2 . THR A 1 188 ? 31.510  22.553  16.364  1.00 49.44  ? 183 THR L CG2 1 
ATOM   1376 N  N   . GLN A 1 189 ? 29.557  19.792  17.447  1.00 43.26  ? 184 GLN L N   1 
ATOM   1377 C  CA  . GLN A 1 189 ? 29.052  19.475  18.776  1.00 40.52  ? 184 GLN L CA  1 
ATOM   1378 C  C   . GLN A 1 189 ? 29.559  18.133  19.286  1.00 38.81  ? 184 GLN L C   1 
ATOM   1379 O  O   . GLN A 1 189 ? 30.025  18.032  20.421  1.00 47.01  ? 184 GLN L O   1 
ATOM   1380 C  CB  . GLN A 1 189 ? 27.526  19.462  18.771  1.00 38.63  ? 184 GLN L CB  1 
ATOM   1381 C  CG  . GLN A 1 189 ? 26.896  20.834  18.751  1.00 44.00  ? 184 GLN L CG  1 
ATOM   1382 C  CD  . GLN A 1 189 ? 25.390  20.763  18.664  1.00 52.69  ? 184 GLN L CD  1 
ATOM   1383 O  OE1 . GLN A 1 189 ? 24.831  19.874  18.011  1.00 44.65  ? 184 GLN L OE1 1 
ATOM   1384 N  NE2 . GLN A 1 189 ? 24.716  21.697  19.328  1.00 54.06  ? 184 GLN L NE2 1 
ATOM   1385 N  N   . TYR A 1 190 ? 29.450  17.107  18.445  1.00 42.47  ? 185 TYR L N   1 
ATOM   1386 C  CA  . TYR A 1 190 ? 29.829  15.750  18.827  1.00 37.98  ? 185 TYR L CA  1 
ATOM   1387 C  C   . TYR A 1 190 ? 31.303  15.712  19.207  1.00 43.99  ? 185 TYR L C   1 
ATOM   1388 O  O   . TYR A 1 190 ? 31.677  15.137  20.232  1.00 42.17  ? 185 TYR L O   1 
ATOM   1389 C  CB  . TYR A 1 190 ? 29.538  14.765  17.685  1.00 42.74  ? 185 TYR L CB  1 
ATOM   1390 C  CG  . TYR A 1 190 ? 29.937  13.331  17.980  1.00 40.86  ? 185 TYR L CG  1 
ATOM   1391 C  CD1 . TYR A 1 190 ? 29.315  12.608  18.993  1.00 34.29  ? 185 TYR L CD1 1 
ATOM   1392 C  CD2 . TYR A 1 190 ? 30.930  12.699  17.243  1.00 36.20  ? 185 TYR L CD2 1 
ATOM   1393 C  CE1 . TYR A 1 190 ? 29.684  11.300  19.274  1.00 36.52  ? 185 TYR L CE1 1 
ATOM   1394 C  CE2 . TYR A 1 190 ? 31.300  11.390  17.513  1.00 36.34  ? 185 TYR L CE2 1 
ATOM   1395 C  CZ  . TYR A 1 190 ? 30.670  10.699  18.524  1.00 33.17  ? 185 TYR L CZ  1 
ATOM   1396 O  OH  . TYR A 1 190 ? 31.041  9.410   18.786  1.00 35.89  ? 185 TYR L OH  1 
ATOM   1397 N  N   . ASN A 1 191 ? 32.135  16.351  18.390  1.00 44.71  ? 186 ASN L N   1 
ATOM   1398 C  CA  . ASN A 1 191 ? 33.574  16.341  18.624  1.00 48.52  ? 186 ASN L CA  1 
ATOM   1399 C  C   . ASN A 1 191 ? 34.013  17.113  19.866  1.00 49.32  ? 186 ASN L C   1 
ATOM   1400 O  O   . ASN A 1 191 ? 35.140  16.954  20.334  1.00 55.34  ? 186 ASN L O   1 
ATOM   1401 C  CB  . ASN A 1 191 ? 34.330  16.828  17.386  1.00 51.27  ? 186 ASN L CB  1 
ATOM   1402 C  CG  . ASN A 1 191 ? 34.460  15.750  16.329  1.00 50.53  ? 186 ASN L CG  1 
ATOM   1403 O  OD1 . ASN A 1 191 ? 34.394  14.560  16.635  1.00 49.36  ? 186 ASN L OD1 1 
ATOM   1404 N  ND2 . ASN A 1 191 ? 34.650  16.159  15.081  1.00 50.22  ? 186 ASN L ND2 1 
ATOM   1405 N  N   . SER A 1 192 ? 33.122  17.933  20.413  1.00 47.20  ? 187 SER L N   1 
ATOM   1406 C  CA  . SER A 1 192 ? 33.469  18.728  21.589  1.00 47.77  ? 187 SER L CA  1 
ATOM   1407 C  C   . SER A 1 192 ? 33.016  18.100  22.908  1.00 49.39  ? 187 SER L C   1 
ATOM   1408 O  O   . SER A 1 192 ? 33.069  18.749  23.953  1.00 47.98  ? 187 SER L O   1 
ATOM   1409 C  CB  . SER A 1 192 ? 32.922  20.155  21.467  1.00 51.34  ? 187 SER L CB  1 
ATOM   1410 O  OG  . SER A 1 192 ? 31.561  20.220  21.853  1.00 58.00  ? 187 SER L OG  1 
ATOM   1411 N  N   . HIS A 1 193 ? 32.577  16.844  22.869  1.00 45.14  ? 188 HIS L N   1 
ATOM   1412 C  CA  . HIS A 1 193 ? 32.214  16.158  24.105  1.00 39.60  ? 188 HIS L CA  1 
ATOM   1413 C  C   . HIS A 1 193 ? 32.730  14.735  24.197  1.00 38.37  ? 188 HIS L C   1 
ATOM   1414 O  O   . HIS A 1 193 ? 33.164  14.155  23.196  1.00 38.08  ? 188 HIS L O   1 
ATOM   1415 C  CB  . HIS A 1 193 ? 30.710  16.208  24.329  1.00 42.17  ? 188 HIS L CB  1 
ATOM   1416 C  CG  . HIS A 1 193 ? 30.193  17.594  24.524  1.00 45.03  ? 188 HIS L CG  1 
ATOM   1417 N  ND1 . HIS A 1 193 ? 29.774  18.381  23.472  1.00 48.57  ? 188 HIS L ND1 1 
ATOM   1418 C  CD2 . HIS A 1 193 ? 30.063  18.348  25.638  1.00 47.16  ? 188 HIS L CD2 1 
ATOM   1419 C  CE1 . HIS A 1 193 ? 29.389  19.556  23.936  1.00 53.90  ? 188 HIS L CE1 1 
ATOM   1420 N  NE2 . HIS A 1 193 ? 29.556  19.565  25.248  1.00 51.08  ? 188 HIS L NE2 1 
ATOM   1421 N  N   . LYS A 1 194 ? 32.673  14.179  25.406  1.00 39.75  ? 189 LYS L N   1 
ATOM   1422 C  CA  . LYS A 1 194 ? 33.277  12.879  25.679  1.00 41.43  ? 189 LYS L CA  1 
ATOM   1423 C  C   . LYS A 1 194 ? 32.280  11.745  25.931  1.00 31.70  ? 189 LYS L C   1 
ATOM   1424 O  O   . LYS A 1 194 ? 32.293  10.736  25.235  1.00 30.59  ? 189 LYS L O   1 
ATOM   1425 C  CB  . LYS A 1 194 ? 34.234  12.987  26.872  1.00 35.48  ? 189 LYS L CB  1 
ATOM   1426 C  CG  . LYS A 1 194 ? 35.047  11.729  27.120  1.00 40.68  ? 189 LYS L CG  1 
ATOM   1427 C  CD  . LYS A 1 194 ? 35.777  11.784  28.459  1.00 49.52  ? 189 LYS L CD  1 
ATOM   1428 C  CE  . LYS A 1 194 ? 36.668  10.558  28.650  1.00 64.11  ? 189 LYS L CE  1 
ATOM   1429 N  NZ  . LYS A 1 194 ? 37.479  10.616  29.900  1.00 64.63  ? 189 LYS L NZ  1 
ATOM   1430 N  N   . GLU A 1 195 ? 31.447  11.896  26.954  1.00 31.97  ? 190 GLU L N   1 
ATOM   1431 C  CA  . GLU A 1 195 ? 30.613  10.787  27.408  1.00 35.47  ? 190 GLU L CA  1 
ATOM   1432 C  C   . GLU A 1 195 ? 29.195  10.896  26.872  1.00 37.14  ? 190 GLU L C   1 
ATOM   1433 O  O   . GLU A 1 195 ? 28.559  11.941  26.985  1.00 38.78  ? 190 GLU L O   1 
ATOM   1434 C  CB  . GLU A 1 195 ? 30.579  10.734  28.933  1.00 36.77  ? 190 GLU L CB  1 
ATOM   1435 C  CG  . GLU A 1 195 ? 29.909  9.493   29.494  1.00 43.09  ? 190 GLU L CG  1 
ATOM   1436 C  CD  . GLU A 1 195 ? 29.700  9.586   30.993  1.00 53.89  ? 190 GLU L CD  1 
ATOM   1437 O  OE1 . GLU A 1 195 ? 29.253  10.657  31.460  1.00 60.75  ? 190 GLU L OE1 1 
ATOM   1438 O  OE2 . GLU A 1 195 ? 29.991  8.599   31.703  1.00 52.19  ? 190 GLU L OE2 1 
ATOM   1439 N  N   . TYR A 1 196 ? 28.699  9.809   26.296  1.00 41.38  ? 191 TYR L N   1 
ATOM   1440 C  CA  . TYR A 1 196 ? 27.355  9.807   25.731  1.00 32.44  ? 191 TYR L CA  1 
ATOM   1441 C  C   . TYR A 1 196 ? 26.520  8.732   26.390  1.00 33.23  ? 191 TYR L C   1 
ATOM   1442 O  O   . TYR A 1 196 ? 26.848  7.551   26.324  1.00 30.71  ? 191 TYR L O   1 
ATOM   1443 C  CB  . TYR A 1 196 ? 27.421  9.640   24.216  1.00 31.81  ? 191 TYR L CB  1 
ATOM   1444 C  CG  . TYR A 1 196 ? 27.992  10.863  23.526  1.00 32.85  ? 191 TYR L CG  1 
ATOM   1445 C  CD1 . TYR A 1 196 ? 27.158  11.873  23.071  1.00 35.70  ? 191 TYR L CD1 1 
ATOM   1446 C  CD2 . TYR A 1 196 ? 29.363  11.021  23.358  1.00 39.94  ? 191 TYR L CD2 1 
ATOM   1447 C  CE1 . TYR A 1 196 ? 27.658  12.994  22.444  1.00 34.10  ? 191 TYR L CE1 1 
ATOM   1448 C  CE2 . TYR A 1 196 ? 29.883  12.148  22.732  1.00 32.72  ? 191 TYR L CE2 1 
ATOM   1449 C  CZ  . TYR A 1 196 ? 29.022  13.131  22.281  1.00 41.10  ? 191 TYR L CZ  1 
ATOM   1450 O  OH  . TYR A 1 196 ? 29.508  14.258  21.661  1.00 38.78  ? 191 TYR L OH  1 
ATOM   1451 N  N   . THR A 1 197 ? 25.441  9.145   27.045  1.00 30.41  ? 192 THR L N   1 
ATOM   1452 C  CA  . THR A 1 197 ? 24.695  8.230   27.901  1.00 29.04  ? 192 THR L CA  1 
ATOM   1453 C  C   . THR A 1 197 ? 23.204  8.136   27.535  1.00 34.76  ? 192 THR L C   1 
ATOM   1454 O  O   . THR A 1 197 ? 22.538  9.146   27.323  1.00 28.91  ? 192 THR L O   1 
ATOM   1455 C  CB  . THR A 1 197 ? 24.855  8.637   29.380  1.00 32.56  ? 192 THR L CB  1 
ATOM   1456 O  OG1 . THR A 1 197 ? 26.226  8.462   29.780  1.00 37.58  ? 192 THR L OG1 1 
ATOM   1457 C  CG2 . THR A 1 197 ? 23.951  7.804   30.288  1.00 31.13  ? 192 THR L CG2 1 
ATOM   1458 N  N   . CYS A 1 198 ? 22.697  6.909   27.454  1.00 28.41  ? 193 CYS L N   1 
ATOM   1459 C  CA  . CYS A 1 198 ? 21.287  6.670   27.233  1.00 23.84  ? 193 CYS L CA  1 
ATOM   1460 C  C   . CYS A 1 198 ? 20.710  6.015   28.475  1.00 25.73  ? 193 CYS L C   1 
ATOM   1461 O  O   . CYS A 1 198 ? 21.165  4.947   28.880  1.00 27.65  ? 193 CYS L O   1 
ATOM   1462 C  CB  . CYS A 1 198 ? 21.092  5.746   26.022  1.00 25.58  ? 193 CYS L CB  1 
ATOM   1463 S  SG  . CYS A 1 198 ? 19.363  5.324   25.710  1.00 34.63  ? 193 CYS L SG  1 
ATOM   1464 N  N   . LYS A 1 199 ? 19.719  6.656   29.087  1.00 25.52  ? 194 LYS L N   1 
ATOM   1465 C  CA  . LYS A 1 199 ? 19.100  6.125   30.297  1.00 27.63  ? 194 LYS L CA  1 
ATOM   1466 C  C   . LYS A 1 199 ? 17.628  5.806   30.064  1.00 21.79  ? 194 LYS L C   1 
ATOM   1467 O  O   . LYS A 1 199 ? 16.843  6.686   29.706  1.00 31.92  ? 194 LYS L O   1 
ATOM   1468 C  CB  . LYS A 1 199 ? 19.250  7.093   31.481  1.00 26.75  ? 194 LYS L CB  1 
ATOM   1469 C  CG  . LYS A 1 199 ? 18.510  6.613   32.727  1.00 24.51  ? 194 LYS L CG  1 
ATOM   1470 C  CD  . LYS A 1 199 ? 18.965  7.293   34.015  1.00 33.47  ? 194 LYS L CD  1 
ATOM   1471 C  CE  . LYS A 1 199 ? 18.464  8.719   34.124  1.00 45.19  ? 194 LYS L CE  1 
ATOM   1472 N  NZ  . LYS A 1 199 ? 18.778  9.277   35.466  1.00 53.93  ? 194 LYS L NZ  1 
ATOM   1473 N  N   . VAL A 1 200 ? 17.261  4.550   30.276  1.00 21.39  ? 195 VAL L N   1 
ATOM   1474 C  CA  . VAL A 1 200 ? 15.904  4.078   30.015  1.00 21.89  ? 195 VAL L CA  1 
ATOM   1475 C  C   . VAL A 1 200 ? 15.288  3.718   31.349  1.00 29.35  ? 195 VAL L C   1 
ATOM   1476 O  O   . VAL A 1 200 ? 15.830  2.881   32.071  1.00 25.40  ? 195 VAL L O   1 
ATOM   1477 C  CB  . VAL A 1 200 ? 15.895  2.843   29.074  1.00 24.15  ? 195 VAL L CB  1 
ATOM   1478 C  CG1 . VAL A 1 200 ? 14.470  2.241   28.958  1.00 21.32  ? 195 VAL L CG1 1 
ATOM   1479 C  CG2 . VAL A 1 200 ? 16.453  3.214   27.702  1.00 17.39  ? 195 VAL L CG2 1 
ATOM   1480 N  N   . THR A 1 201 ? 14.170  4.367   31.675  1.00 23.89  ? 196 THR L N   1 
ATOM   1481 C  CA  . THR A 1 201 ? 13.579  4.274   33.007  1.00 24.20  ? 196 THR L CA  1 
ATOM   1482 C  C   . THR A 1 201 ? 12.192  3.651   32.965  1.00 23.90  ? 196 THR L C   1 
ATOM   1483 O  O   . THR A 1 201 ? 11.336  4.090   32.196  1.00 27.35  ? 196 THR L O   1 
ATOM   1484 C  CB  . THR A 1 201 ? 13.454  5.671   33.649  1.00 27.68  ? 196 THR L CB  1 
ATOM   1485 O  OG1 . THR A 1 201 ? 14.751  6.256   33.772  1.00 23.95  ? 196 THR L OG1 1 
ATOM   1486 C  CG2 . THR A 1 201 ? 12.787  5.588   35.028  1.00 27.13  ? 196 THR L CG2 1 
ATOM   1487 N  N   . GLN A 1 202 ? 11.985  2.646   33.810  1.00 23.03  ? 197 GLN L N   1 
ATOM   1488 C  CA  . GLN A 1 202 ? 10.703  1.984   33.962  1.00 31.71  ? 197 GLN L CA  1 
ATOM   1489 C  C   . GLN A 1 202 ? 10.331  1.996   35.444  1.00 30.46  ? 197 GLN L C   1 
ATOM   1490 O  O   . GLN A 1 202 ? 10.893  1.243   36.244  1.00 31.27  ? 197 GLN L O   1 
ATOM   1491 C  CB  . GLN A 1 202 ? 10.800  0.549   33.442  1.00 30.89  ? 197 GLN L CB  1 
ATOM   1492 C  CG  . GLN A 1 202 ? 9.482   -0.117  33.188  1.00 28.48  ? 197 GLN L CG  1 
ATOM   1493 C  CD  . GLN A 1 202 ? 9.649   -1.557  32.747  1.00 29.38  ? 197 GLN L CD  1 
ATOM   1494 O  OE1 . GLN A 1 202 ? 10.360  -2.336  33.380  1.00 24.32  ? 197 GLN L OE1 1 
ATOM   1495 N  NE2 . GLN A 1 202 ? 8.988   -1.921  31.659  1.00 16.61  ? 197 GLN L NE2 1 
ATOM   1496 N  N   . GLY A 1 203 ? 9.387   2.856   35.807  1.00 33.14  ? 198 GLY L N   1 
ATOM   1497 C  CA  . GLY A 1 203 ? 9.037   3.034   37.204  1.00 35.30  ? 198 GLY L CA  1 
ATOM   1498 C  C   . GLY A 1 203 ? 10.161  3.790   37.878  1.00 27.80  ? 198 GLY L C   1 
ATOM   1499 O  O   . GLY A 1 203 ? 10.495  4.895   37.465  1.00 32.68  ? 198 GLY L O   1 
ATOM   1500 N  N   . THR A 1 204 ? 10.766  3.189   38.897  1.00 27.65  ? 199 THR L N   1 
ATOM   1501 C  CA  . THR A 1 204 ? 11.899  3.822   39.569  1.00 35.32  ? 199 THR L CA  1 
ATOM   1502 C  C   . THR A 1 204 ? 13.223  3.111   39.284  1.00 37.58  ? 199 THR L C   1 
ATOM   1503 O  O   . THR A 1 204 ? 14.235  3.387   39.934  1.00 29.42  ? 199 THR L O   1 
ATOM   1504 C  CB  . THR A 1 204 ? 11.686  3.871   41.080  1.00 33.47  ? 199 THR L CB  1 
ATOM   1505 O  OG1 . THR A 1 204 ? 11.410  2.547   41.556  1.00 35.79  ? 199 THR L OG1 1 
ATOM   1506 C  CG2 . THR A 1 204 ? 10.504  4.804   41.416  1.00 32.04  ? 199 THR L CG2 1 
ATOM   1507 N  N   . THR A 1 205 ? 13.210  2.185   38.326  1.00 34.64  ? 200 THR L N   1 
ATOM   1508 C  CA  . THR A 1 205 ? 14.415  1.441   37.962  1.00 27.61  ? 200 THR L CA  1 
ATOM   1509 C  C   . THR A 1 205 ? 14.895  1.792   36.564  1.00 34.50  ? 200 THR L C   1 
ATOM   1510 O  O   . THR A 1 205 ? 14.146  1.700   35.589  1.00 31.27  ? 200 THR L O   1 
ATOM   1511 C  CB  . THR A 1 205 ? 14.186  -0.067  38.016  1.00 35.33  ? 200 THR L CB  1 
ATOM   1512 O  OG1 . THR A 1 205 ? 13.789  -0.441  39.337  1.00 35.58  ? 200 THR L OG1 1 
ATOM   1513 C  CG2 . THR A 1 205 ? 15.468  -0.814  37.641  1.00 38.31  ? 200 THR L CG2 1 
ATOM   1514 N  N   . SER A 1 206 ? 16.153  2.190   36.470  1.00 28.88  ? 201 SER L N   1 
ATOM   1515 C  CA  . SER A 1 206 ? 16.723  2.565   35.194  1.00 25.13  ? 201 SER L CA  1 
ATOM   1516 C  C   . SER A 1 206 ? 17.787  1.572   34.753  1.00 31.59  ? 201 SER L C   1 
ATOM   1517 O  O   . SER A 1 206 ? 18.419  0.918   35.583  1.00 29.94  ? 201 SER L O   1 
ATOM   1518 C  CB  . SER A 1 206 ? 17.331  3.965   35.261  1.00 25.35  ? 201 SER L CB  1 
ATOM   1519 O  OG  . SER A 1 206 ? 16.356  4.962   35.500  1.00 29.57  ? 201 SER L OG  1 
ATOM   1520 N  N   . VAL A 1 207 ? 17.959  1.455   33.438  1.00 29.53  ? 202 VAL L N   1 
ATOM   1521 C  CA  . VAL A 1 207 ? 19.097  0.767   32.847  1.00 25.67  ? 202 VAL L CA  1 
ATOM   1522 C  C   . VAL A 1 207 ? 19.860  1.836   32.078  1.00 28.77  ? 202 VAL L C   1 
ATOM   1523 O  O   . VAL A 1 207 ? 19.261  2.641   31.363  1.00 30.56  ? 202 VAL L O   1 
ATOM   1524 C  CB  . VAL A 1 207 ? 18.665  -0.385  31.909  1.00 31.40  ? 202 VAL L CB  1 
ATOM   1525 C  CG1 . VAL A 1 207 ? 19.872  -0.982  31.188  1.00 30.62  ? 202 VAL L CG1 1 
ATOM   1526 C  CG2 . VAL A 1 207 ? 17.943  -1.461  32.689  1.00 27.93  ? 202 VAL L CG2 1 
ATOM   1527 N  N   . VAL A 1 208 ? 21.175  1.881   32.259  1.00 31.94  ? 203 VAL L N   1 
ATOM   1528 C  CA  . VAL A 1 208 ? 21.977  2.963   31.701  1.00 28.28  ? 203 VAL L CA  1 
ATOM   1529 C  C   . VAL A 1 208 ? 23.083  2.393   30.813  1.00 32.73  ? 203 VAL L C   1 
ATOM   1530 O  O   . VAL A 1 208 ? 23.808  1.498   31.229  1.00 36.89  ? 203 VAL L O   1 
ATOM   1531 C  CB  . VAL A 1 208 ? 22.629  3.817   32.819  1.00 37.17  ? 203 VAL L CB  1 
ATOM   1532 C  CG1 . VAL A 1 208 ? 23.484  4.901   32.224  1.00 30.10  ? 203 VAL L CG1 1 
ATOM   1533 C  CG2 . VAL A 1 208 ? 21.573  4.428   33.736  1.00 34.05  ? 203 VAL L CG2 1 
ATOM   1534 N  N   . GLN A 1 209 ? 23.202  2.903   29.590  1.00 36.70  ? 204 GLN L N   1 
ATOM   1535 C  CA  . GLN A 1 209 ? 24.300  2.507   28.711  1.00 31.12  ? 204 GLN L CA  1 
ATOM   1536 C  C   . GLN A 1 209 ? 25.054  3.741   28.227  1.00 29.15  ? 204 GLN L C   1 
ATOM   1537 O  O   . GLN A 1 209 ? 24.446  4.754   27.870  1.00 27.06  ? 204 GLN L O   1 
ATOM   1538 C  CB  . GLN A 1 209 ? 23.797  1.680   27.523  1.00 27.73  ? 204 GLN L CB  1 
ATOM   1539 C  CG  . GLN A 1 209 ? 23.178  0.330   27.906  1.00 25.87  ? 204 GLN L CG  1 
ATOM   1540 C  CD  . GLN A 1 209 ? 24.218  -0.689  28.317  1.00 34.17  ? 204 GLN L CD  1 
ATOM   1541 O  OE1 . GLN A 1 209 ? 25.416  -0.436  28.207  1.00 34.95  ? 204 GLN L OE1 1 
ATOM   1542 N  NE2 . GLN A 1 209 ? 23.769  -1.850  28.790  1.00 29.41  ? 204 GLN L NE2 1 
ATOM   1543 N  N   . SER A 1 210 ? 26.382  3.656   28.215  1.00 32.34  ? 205 SER L N   1 
ATOM   1544 C  CA  . SER A 1 210 ? 27.222  4.783   27.820  1.00 27.27  ? 205 SER L CA  1 
ATOM   1545 C  C   . SER A 1 210 ? 28.435  4.335   27.004  1.00 30.22  ? 205 SER L C   1 
ATOM   1546 O  O   . SER A 1 210 ? 28.842  3.177   27.075  1.00 25.51  ? 205 SER L O   1 
ATOM   1547 C  CB  . SER A 1 210 ? 27.733  5.521   29.062  1.00 31.46  ? 205 SER L CB  1 
ATOM   1548 O  OG  . SER A 1 210 ? 26.671  5.958   29.885  1.00 41.62  ? 205 SER L OG  1 
ATOM   1549 N  N   . PHE A 1 211 ? 28.996  5.265   26.232  1.00 24.45  ? 206 PHE L N   1 
ATOM   1550 C  CA  . PHE A 1 211 ? 30.320  5.092   25.626  1.00 29.35  ? 206 PHE L CA  1 
ATOM   1551 C  C   . PHE A 1 211 ? 31.073  6.422   25.654  1.00 37.32  ? 206 PHE L C   1 
ATOM   1552 O  O   . PHE A 1 211 ? 30.465  7.490   25.809  1.00 33.05  ? 206 PHE L O   1 
ATOM   1553 C  CB  . PHE A 1 211 ? 30.235  4.592   24.177  1.00 30.92  ? 206 PHE L CB  1 
ATOM   1554 C  CG  . PHE A 1 211 ? 29.657  5.597   23.213  1.00 33.36  ? 206 PHE L CG  1 
ATOM   1555 C  CD1 . PHE A 1 211 ? 30.481  6.435   22.477  1.00 30.06  ? 206 PHE L CD1 1 
ATOM   1556 C  CD2 . PHE A 1 211 ? 28.284  5.686   23.026  1.00 30.02  ? 206 PHE L CD2 1 
ATOM   1557 C  CE1 . PHE A 1 211 ? 29.949  7.355   21.581  1.00 32.97  ? 206 PHE L CE1 1 
ATOM   1558 C  CE2 . PHE A 1 211 ? 27.743  6.607   22.128  1.00 27.87  ? 206 PHE L CE2 1 
ATOM   1559 C  CZ  . PHE A 1 211 ? 28.579  7.441   21.407  1.00 27.04  ? 206 PHE L CZ  1 
ATOM   1560 N  N   . ASN A 1 212 ? 32.394  6.352   25.507  1.00 37.29  ? 207 ASN L N   1 
ATOM   1561 C  CA  . ASN A 1 212 ? 33.203  7.550   25.304  1.00 35.37  ? 207 ASN L CA  1 
ATOM   1562 C  C   . ASN A 1 212 ? 33.569  7.691   23.838  1.00 40.16  ? 207 ASN L C   1 
ATOM   1563 O  O   . ASN A 1 212 ? 33.964  6.716   23.195  1.00 41.41  ? 207 ASN L O   1 
ATOM   1564 C  CB  . ASN A 1 212 ? 34.474  7.503   26.146  1.00 45.46  ? 207 ASN L CB  1 
ATOM   1565 C  CG  . ASN A 1 212 ? 34.195  7.571   27.623  1.00 38.73  ? 207 ASN L CG  1 
ATOM   1566 O  OD1 . ASN A 1 212 ? 33.331  8.318   28.067  1.00 45.53  ? 207 ASN L OD1 1 
ATOM   1567 N  ND2 . ASN A 1 212 ? 34.936  6.788   28.400  1.00 55.37  ? 207 ASN L ND2 1 
ATOM   1568 N  N   . ARG A 1 213 ? 33.430  8.903   23.311  1.00 38.05  ? 208 ARG L N   1 
ATOM   1569 C  CA  . ARG A 1 213 ? 33.658  9.153   21.891  1.00 38.97  ? 208 ARG L CA  1 
ATOM   1570 C  C   . ARG A 1 213 ? 34.998  8.615   21.390  1.00 47.31  ? 208 ARG L C   1 
ATOM   1571 O  O   . ARG A 1 213 ? 35.074  7.970   20.337  1.00 46.04  ? 208 ARG L O   1 
ATOM   1572 C  CB  . ARG A 1 213 ? 33.558  10.648  21.598  1.00 38.54  ? 208 ARG L CB  1 
ATOM   1573 C  CG  . ARG A 1 213 ? 33.970  11.026  20.183  1.00 38.26  ? 208 ARG L CG  1 
ATOM   1574 C  CD  . ARG A 1 213 ? 33.765  12.519  19.956  1.00 47.43  ? 208 ARG L CD  1 
ATOM   1575 N  NE  . ARG A 1 213 ? 34.383  13.303  21.022  1.00 51.14  ? 208 ARG L NE  1 
ATOM   1576 C  CZ  . ARG A 1 213 ? 35.670  13.639  21.048  1.00 49.55  ? 208 ARG L CZ  1 
ATOM   1577 N  NH1 . ARG A 1 213 ? 36.479  13.257  20.061  1.00 37.88  ? 208 ARG L NH1 1 
ATOM   1578 N  NH2 . ARG A 1 213 ? 36.147  14.351  22.061  1.00 42.36  ? 208 ARG L NH2 1 
ATOM   1579 N  N   . GLY A 1 214 ? 36.052  8.875   22.155  1.00 45.16  ? 209 GLY L N   1 
ATOM   1580 C  CA  . GLY A 1 214 ? 37.389  8.477   21.753  1.00 55.37  ? 209 GLY L CA  1 
ATOM   1581 C  C   . GLY A 1 214 ? 37.733  7.021   22.008  1.00 50.31  ? 209 GLY L C   1 
ATOM   1582 O  O   . GLY A 1 214 ? 38.871  6.608   21.797  1.00 58.88  ? 209 GLY L O   1 
ATOM   1583 N  N   . ASP A 1 215 ? 36.757  6.238   22.457  1.00 52.61  ? 210 ASP L N   1 
ATOM   1584 C  CA  . ASP A 1 215 ? 36.985  4.822   22.746  1.00 46.40  ? 210 ASP L CA  1 
ATOM   1585 C  C   . ASP A 1 215 ? 36.508  3.896   21.622  1.00 50.47  ? 210 ASP L C   1 
ATOM   1586 O  O   . ASP A 1 215 ? 36.775  2.693   21.647  1.00 56.79  ? 210 ASP L O   1 
ATOM   1587 C  CB  . ASP A 1 215 ? 36.302  4.425   24.061  1.00 51.68  ? 210 ASP L CB  1 
ATOM   1588 C  CG  . ASP A 1 215 ? 37.031  4.947   25.287  1.00 62.77  ? 210 ASP L CG  1 
ATOM   1589 O  OD1 . ASP A 1 215 ? 38.048  5.658   25.128  1.00 61.77  ? 210 ASP L OD1 1 
ATOM   1590 O  OD2 . ASP A 1 215 ? 36.578  4.654   26.415  1.00 56.23  ? 210 ASP L OD2 1 
ATOM   1591 N  N   . CYS A 1 216 ? 35.800  4.443   20.641  1.00 52.39  ? 211 CYS L N   1 
ATOM   1592 C  CA  . CYS A 1 216 ? 35.188  3.601   19.609  1.00 54.76  ? 211 CYS L CA  1 
ATOM   1593 C  C   . CYS A 1 216 ? 35.952  3.606   18.278  1.00 51.45  ? 211 CYS L C   1 
ATOM   1594 O  O   . CYS A 1 216 ? 36.966  4.292   18.133  1.00 56.52  ? 211 CYS L O   1 
ATOM   1595 C  CB  . CYS A 1 216 ? 33.718  3.995   19.409  1.00 51.21  ? 211 CYS L CB  1 
ATOM   1596 S  SG  . CYS A 1 216 ? 32.734  3.793   20.944  1.00 58.89  ? 211 CYS L SG  1 
ATOM   1597 N  N   . GLN B 2 1   ? -7.282  -17.663 -3.658  1.00 46.25  ? 2   GLN H N   1 
ATOM   1598 C  CA  . GLN B 2 1   ? -7.923  -16.443 -4.124  1.00 33.64  ? 2   GLN H CA  1 
ATOM   1599 C  C   . GLN B 2 1   ? -7.357  -15.250 -3.374  1.00 32.77  ? 2   GLN H C   1 
ATOM   1600 O  O   . GLN B 2 1   ? -7.306  -15.259 -2.146  1.00 27.78  ? 2   GLN H O   1 
ATOM   1601 C  CB  . GLN B 2 1   ? -9.449  -16.533 -3.975  1.00 41.45  ? 2   GLN H CB  1 
ATOM   1602 C  CG  . GLN B 2 1   ? -9.970  -16.870 -2.576  1.00 49.05  ? 2   GLN H CG  1 
ATOM   1603 C  CD  . GLN B 2 1   ? -9.646  -18.293 -2.117  1.00 58.43  ? 2   GLN H CD  1 
ATOM   1604 O  OE1 . GLN B 2 1   ? -8.833  -18.988 -2.731  1.00 50.03  ? 2   GLN H OE1 1 
ATOM   1605 N  NE2 . GLN B 2 1   ? -10.282 -18.727 -1.024  1.00 57.27  ? 2   GLN H NE2 1 
ATOM   1606 N  N   . SER B 2 2   ? -6.910  -14.234 -4.115  1.00 27.87  ? 3   SER H N   1 
ATOM   1607 C  CA  . SER B 2 2   ? -6.256  -13.084 -3.506  1.00 25.89  ? 3   SER H CA  1 
ATOM   1608 C  C   . SER B 2 2   ? -6.308  -11.842 -4.401  1.00 25.56  ? 3   SER H C   1 
ATOM   1609 O  O   . SER B 2 2   ? -6.615  -11.924 -5.590  1.00 23.41  ? 3   SER H O   1 
ATOM   1610 C  CB  . SER B 2 2   ? -4.807  -13.430 -3.197  1.00 27.68  ? 3   SER H CB  1 
ATOM   1611 O  OG  . SER B 2 2   ? -4.090  -13.625 -4.401  1.00 28.13  ? 3   SER H OG  1 
ATOM   1612 N  N   . LEU B 2 3   ? -6.002  -10.693 -3.817  1.00 26.22  ? 4   LEU H N   1 
ATOM   1613 C  CA  . LEU B 2 3   ? -6.024  -9.433  -4.543  1.00 23.40  ? 4   LEU H CA  1 
ATOM   1614 C  C   . LEU B 2 3   ? -4.685  -8.748  -4.400  1.00 22.58  ? 4   LEU H C   1 
ATOM   1615 O  O   . LEU B 2 3   ? -4.030  -8.871  -3.373  1.00 25.16  ? 4   LEU H O   1 
ATOM   1616 C  CB  . LEU B 2 3   ? -7.124  -8.520  -3.995  1.00 21.44  ? 4   LEU H CB  1 
ATOM   1617 C  CG  . LEU B 2 3   ? -8.558  -9.018  -4.184  1.00 23.25  ? 4   LEU H CG  1 
ATOM   1618 C  CD1 . LEU B 2 3   ? -9.532  -8.196  -3.346  1.00 18.98  ? 4   LEU H CD1 1 
ATOM   1619 C  CD2 . LEU B 2 3   ? -8.955  -8.983  -5.655  1.00 15.49  ? 4   LEU H CD2 1 
ATOM   1620 N  N   . GLU B 2 4   ? -4.276  -8.019  -5.431  1.00 23.04  ? 5   GLU H N   1 
ATOM   1621 C  CA  . GLU B 2 4   ? -3.091  -7.185  -5.320  1.00 20.29  ? 5   GLU H CA  1 
ATOM   1622 C  C   . GLU B 2 4   ? -3.306  -5.859  -6.043  1.00 23.09  ? 5   GLU H C   1 
ATOM   1623 O  O   . GLU B 2 4   ? -3.718  -5.845  -7.217  1.00 23.76  ? 5   GLU H O   1 
ATOM   1624 C  CB  . GLU B 2 4   ? -1.845  -7.890  -5.875  1.00 24.51  ? 5   GLU H CB  1 
ATOM   1625 C  CG  . GLU B 2 4   ? -0.580  -7.064  -5.642  1.00 31.73  ? 5   GLU H CG  1 
ATOM   1626 C  CD  . GLU B 2 4   ? 0.686   -7.734  -6.141  1.00 47.31  ? 5   GLU H CD  1 
ATOM   1627 O  OE1 . GLU B 2 4   ? 0.602   -8.779  -6.823  1.00 47.29  ? 5   GLU H OE1 1 
ATOM   1628 O  OE2 . GLU B 2 4   ? 1.775   -7.203  -5.849  1.00 53.86  ? 5   GLU H OE2 1 
ATOM   1629 N  N   . GLU B 2 5   ? -3.051  -4.758  -5.335  1.00 20.07  ? 6   GLU H N   1 
ATOM   1630 C  CA  . GLU B 2 5   ? -3.124  -3.406  -5.906  1.00 16.75  ? 6   GLU H CA  1 
ATOM   1631 C  C   . GLU B 2 5   ? -1.750  -2.977  -6.414  1.00 22.61  ? 6   GLU H C   1 
ATOM   1632 O  O   . GLU B 2 5   ? -0.726  -3.333  -5.821  1.00 21.44  ? 6   GLU H O   1 
ATOM   1633 C  CB  . GLU B 2 5   ? -3.569  -2.386  -4.852  1.00 22.18  ? 6   GLU H CB  1 
ATOM   1634 C  CG  . GLU B 2 5   ? -4.858  -2.703  -4.089  1.00 17.48  ? 6   GLU H CG  1 
ATOM   1635 C  CD  . GLU B 2 5   ? -4.621  -3.509  -2.812  1.00 21.24  ? 6   GLU H CD  1 
ATOM   1636 O  OE1 . GLU B 2 5   ? -5.568  -3.652  -2.007  1.00 19.66  ? 6   GLU H OE1 1 
ATOM   1637 O  OE2 . GLU B 2 5   ? -3.496  -4.015  -2.620  1.00 21.81  ? 6   GLU H OE2 1 
ATOM   1638 N  N   . SER B 2 6   ? -1.719  -2.184  -7.480  1.00 19.42  ? 7   SER H N   1 
ATOM   1639 C  CA  . SER B 2 6   ? -0.453  -1.641  -7.977  1.00 24.66  ? 7   SER H CA  1 
ATOM   1640 C  C   . SER B 2 6   ? -0.673  -0.275  -8.592  1.00 30.08  ? 7   SER H C   1 
ATOM   1641 O  O   . SER B 2 6   ? -1.818  0.109   -8.836  1.00 21.11  ? 7   SER H O   1 
ATOM   1642 C  CB  . SER B 2 6   ? 0.165   -2.581  -9.016  1.00 22.56  ? 7   SER H CB  1 
ATOM   1643 O  OG  . SER B 2 6   ? -0.663  -2.677  -10.164 1.00 22.96  ? 7   SER H OG  1 
ATOM   1644 N  N   . GLY B 2 7   ? 0.420   0.448   -8.836  1.00 20.22  ? 8   GLY H N   1 
ATOM   1645 C  CA  . GLY B 2 7   ? 0.357   1.761   -9.453  1.00 23.14  ? 8   GLY H CA  1 
ATOM   1646 C  C   . GLY B 2 7   ? 0.610   2.922   -8.502  1.00 23.22  ? 8   GLY H C   1 
ATOM   1647 O  O   . GLY B 2 7   ? 0.661   4.068   -8.923  1.00 25.39  ? 8   GLY H O   1 
ATOM   1648 N  N   . GLY B 2 8   ? 0.751   2.633   -7.213  1.00 26.16  ? 9   GLY H N   1 
ATOM   1649 C  CA  . GLY B 2 8   ? 1.105   3.663   -6.248  1.00 21.97  ? 9   GLY H CA  1 
ATOM   1650 C  C   . GLY B 2 8   ? 2.399   4.365   -6.659  1.00 30.63  ? 9   GLY H C   1 
ATOM   1651 O  O   . GLY B 2 8   ? 3.310   3.744   -7.197  1.00 23.06  ? 9   GLY H O   1 
ATOM   1652 N  N   . ASP B 2 9   ? 2.484   5.663   -6.418  1.00 27.70  ? 10  ASP H N   1 
ATOM   1653 C  CA  . ASP B 2 9   ? 3.651   6.422   -6.856  1.00 31.24  ? 10  ASP H CA  1 
ATOM   1654 C  C   . ASP B 2 9   ? 3.675   7.791   -6.195  1.00 31.92  ? 10  ASP H C   1 
ATOM   1655 O  O   . ASP B 2 9   ? 2.698   8.205   -5.563  1.00 25.48  ? 10  ASP H O   1 
ATOM   1656 C  CB  . ASP B 2 9   ? 3.654   6.569   -8.389  1.00 30.92  ? 10  ASP H CB  1 
ATOM   1657 C  CG  . ASP B 2 9   ? 5.049   6.863   -8.960  1.00 42.42  ? 10  ASP H CG  1 
ATOM   1658 O  OD1 . ASP B 2 9   ? 5.166   7.006   -10.195 1.00 45.66  ? 10  ASP H OD1 1 
ATOM   1659 O  OD2 . ASP B 2 9   ? 6.028   6.957   -8.184  1.00 39.99  ? 10  ASP H OD2 1 
ATOM   1660 N  N   . LEU B 2 10  ? 4.803   8.485   -6.329  1.00 28.39  ? 11  LEU H N   1 
ATOM   1661 C  CA  . LEU B 2 10  ? 4.903   9.876   -5.917  1.00 28.28  ? 11  LEU H CA  1 
ATOM   1662 C  C   . LEU B 2 10  ? 4.474   10.752  -7.097  1.00 27.68  ? 11  LEU H C   1 
ATOM   1663 O  O   . LEU B 2 10  ? 4.986   10.603  -8.197  1.00 31.00  ? 11  LEU H O   1 
ATOM   1664 C  CB  . LEU B 2 10  ? 6.350   10.199  -5.517  1.00 31.48  ? 11  LEU H CB  1 
ATOM   1665 C  CG  . LEU B 2 10  ? 6.735   11.675  -5.369  1.00 27.22  ? 11  LEU H CG  1 
ATOM   1666 C  CD1 . LEU B 2 10  ? 6.193   12.264  -4.093  1.00 24.44  ? 11  LEU H CD1 1 
ATOM   1667 C  CD2 . LEU B 2 10  ? 8.260   11.835  -5.415  1.00 36.00  ? 11  LEU H CD2 1 
ATOM   1668 N  N   . VAL B 2 11  ? 3.536   11.664  -6.882  1.00 27.90  ? 12  VAL H N   1 
ATOM   1669 C  CA  . VAL B 2 11  ? 3.074   12.524  -7.974  1.00 26.94  ? 12  VAL H CA  1 
ATOM   1670 C  C   . VAL B 2 11  ? 2.938   13.969  -7.527  1.00 31.66  ? 12  VAL H C   1 
ATOM   1671 O  O   . VAL B 2 11  ? 2.812   14.245  -6.337  1.00 29.86  ? 12  VAL H O   1 
ATOM   1672 C  CB  . VAL B 2 11  ? 1.723   12.040  -8.583  1.00 33.29  ? 12  VAL H CB  1 
ATOM   1673 C  CG1 . VAL B 2 11  ? 1.861   10.633  -9.145  1.00 31.59  ? 12  VAL H CG1 1 
ATOM   1674 C  CG2 . VAL B 2 11  ? 0.607   12.098  -7.550  1.00 25.13  ? 12  VAL H CG2 1 
ATOM   1675 N  N   . GLN B 2 12  ? 2.959   14.894  -8.483  1.00 31.83  ? 13  GLN H N   1 
ATOM   1676 C  CA  . GLN B 2 12  ? 2.857   16.309  -8.158  1.00 27.81  ? 13  GLN H CA  1 
ATOM   1677 C  C   . GLN B 2 12  ? 1.390   16.705  -7.948  1.00 29.14  ? 13  GLN H C   1 
ATOM   1678 O  O   . GLN B 2 12  ? 0.490   16.080  -8.506  1.00 26.77  ? 13  GLN H O   1 
ATOM   1679 C  CB  . GLN B 2 12  ? 3.483   17.150  -9.279  1.00 42.12  ? 13  GLN H CB  1 
ATOM   1680 C  CG  . GLN B 2 12  ? 4.830   16.619  -9.791  1.00 49.66  ? 13  GLN H CG  1 
ATOM   1681 C  CD  . GLN B 2 12  ? 6.024   17.429  -9.300  1.00 58.68  ? 13  GLN H CD  1 
ATOM   1682 O  OE1 . GLN B 2 12  ? 5.893   18.284  -8.423  1.00 57.51  ? 13  GLN H OE1 1 
ATOM   1683 N  NE2 . GLN B 2 12  ? 7.195   17.167  -9.874  1.00 61.93  ? 13  GLN H NE2 1 
ATOM   1684 N  N   . PRO B 2 13  ? 1.145   17.738  -7.128  1.00 24.79  ? 14  PRO H N   1 
ATOM   1685 C  CA  . PRO B 2 13  ? -0.215  18.254  -6.963  1.00 27.15  ? 14  PRO H CA  1 
ATOM   1686 C  C   . PRO B 2 13  ? -0.801  18.595  -8.327  1.00 33.56  ? 14  PRO H C   1 
ATOM   1687 O  O   . PRO B 2 13  ? -0.063  19.078  -9.184  1.00 26.95  ? 14  PRO H O   1 
ATOM   1688 C  CB  . PRO B 2 13  ? -0.000  19.540  -6.158  1.00 32.85  ? 14  PRO H CB  1 
ATOM   1689 C  CG  . PRO B 2 13  ? 1.249   19.284  -5.373  1.00 33.91  ? 14  PRO H CG  1 
ATOM   1690 C  CD  . PRO B 2 13  ? 2.117   18.419  -6.251  1.00 30.09  ? 14  PRO H CD  1 
ATOM   1691 N  N   . GLY B 2 14  ? -2.084  18.309  -8.536  1.00 35.21  ? 15  GLY H N   1 
ATOM   1692 C  CA  . GLY B 2 14  ? -2.726  18.543  -9.823  1.00 26.48  ? 15  GLY H CA  1 
ATOM   1693 C  C   . GLY B 2 14  ? -2.704  17.342  -10.753 1.00 27.24  ? 15  GLY H C   1 
ATOM   1694 O  O   . GLY B 2 14  ? -3.439  17.296  -11.738 1.00 28.14  ? 15  GLY H O   1 
ATOM   1695 N  N   . ALA B 2 15  ? -1.870  16.358  -10.444 1.00 25.30  ? 16  ALA H N   1 
ATOM   1696 C  CA  . ALA B 2 15  ? -1.718  15.189  -11.324 1.00 27.77  ? 16  ALA H CA  1 
ATOM   1697 C  C   . ALA B 2 15  ? -2.929  14.253  -11.366 1.00 27.61  ? 16  ALA H C   1 
ATOM   1698 O  O   . ALA B 2 15  ? -3.847  14.362  -10.548 1.00 21.62  ? 16  ALA H O   1 
ATOM   1699 C  CB  . ALA B 2 15  ? -0.477  14.402  -10.945 1.00 27.36  ? 16  ALA H CB  1 
ATOM   1700 N  N   . SER B 2 16  ? -2.899  13.348  -12.342 1.00 25.22  ? 17  SER H N   1 
ATOM   1701 C  CA  . SER B 2 16  ? -3.812  12.217  -12.444 1.00 26.30  ? 17  SER H CA  1 
ATOM   1702 C  C   . SER B 2 16  ? -3.036  10.911  -12.249 1.00 26.10  ? 17  SER H C   1 
ATOM   1703 O  O   . SER B 2 16  ? -1.819  10.857  -12.479 1.00 28.21  ? 17  SER H O   1 
ATOM   1704 C  CB  . SER B 2 16  ? -4.519  12.211  -13.806 1.00 25.95  ? 17  SER H CB  1 
ATOM   1705 O  OG  . SER B 2 16  ? -5.407  13.313  -13.901 1.00 28.35  ? 17  SER H OG  1 
ATOM   1706 N  N   . LEU B 2 17  ? -3.737  9.866   -11.821 1.00 22.19  ? 18  LEU H N   1 
ATOM   1707 C  CA  . LEU B 2 17  ? -3.103  8.577   -11.553 1.00 18.79  ? 18  LEU H CA  1 
ATOM   1708 C  C   . LEU B 2 17  ? -4.124  7.455   -11.560 1.00 21.52  ? 18  LEU H C   1 
ATOM   1709 O  O   . LEU B 2 17  ? -5.226  7.619   -11.037 1.00 21.82  ? 18  LEU H O   1 
ATOM   1710 C  CB  . LEU B 2 17  ? -2.377  8.618   -10.192 1.00 20.00  ? 18  LEU H CB  1 
ATOM   1711 C  CG  . LEU B 2 17  ? -1.598  7.360   -9.784  1.00 20.41  ? 18  LEU H CG  1 
ATOM   1712 C  CD1 . LEU B 2 17  ? -0.442  7.090   -10.743 1.00 26.17  ? 18  LEU H CD1 1 
ATOM   1713 C  CD2 . LEU B 2 17  ? -1.081  7.496   -8.343  1.00 22.00  ? 18  LEU H CD2 1 
ATOM   1714 N  N   . THR B 2 18  ? -3.755  6.313   -12.145 1.00 21.36  ? 19  THR H N   1 
ATOM   1715 C  CA  . THR B 2 18  ? -4.644  5.160   -12.196 1.00 20.48  ? 19  THR H CA  1 
ATOM   1716 C  C   . THR B 2 18  ? -4.068  3.970   -11.418 1.00 23.40  ? 19  THR H C   1 
ATOM   1717 O  O   . THR B 2 18  ? -2.946  3.541   -11.669 1.00 21.36  ? 19  THR H O   1 
ATOM   1718 C  CB  . THR B 2 18  ? -4.913  4.737   -13.651 1.00 26.65  ? 19  THR H CB  1 
ATOM   1719 O  OG1 . THR B 2 18  ? -5.597  5.791   -14.327 1.00 21.64  ? 19  THR H OG1 1 
ATOM   1720 C  CG2 . THR B 2 18  ? -5.762  3.472   -13.698 1.00 22.37  ? 19  THR H CG2 1 
ATOM   1721 N  N   . LEU B 2 19  ? -4.831  3.456   -10.459 1.00 19.02  ? 20  LEU H N   1 
ATOM   1722 C  CA  . LEU B 2 19  ? -4.413  2.266   -9.711  1.00 19.07  ? 20  LEU H CA  1 
ATOM   1723 C  C   . LEU B 2 19  ? -5.126  1.037   -10.270 1.00 19.94  ? 20  LEU H C   1 
ATOM   1724 O  O   . LEU B 2 19  ? -6.229  1.141   -10.807 1.00 23.06  ? 20  LEU H O   1 
ATOM   1725 C  CB  . LEU B 2 19  ? -4.726  2.426   -8.224  1.00 17.54  ? 20  LEU H CB  1 
ATOM   1726 C  CG  . LEU B 2 19  ? -4.192  3.670   -7.514  1.00 24.85  ? 20  LEU H CG  1 
ATOM   1727 C  CD1 . LEU B 2 19  ? -4.596  3.657   -6.024  1.00 17.71  ? 20  LEU H CD1 1 
ATOM   1728 C  CD2 . LEU B 2 19  ? -2.669  3.780   -7.655  1.00 21.51  ? 20  LEU H CD2 1 
ATOM   1729 N  N   . THR B 2 20  ? -4.507  -0.128  -10.133 1.00 20.69  ? 21  THR H N   1 
ATOM   1730 C  CA  . THR B 2 20  ? -5.103  -1.370  -10.607 1.00 21.72  ? 21  THR H CA  1 
ATOM   1731 C  C   . THR B 2 20  ? -5.220  -2.400  -9.500  1.00 25.39  ? 21  THR H C   1 
ATOM   1732 O  O   . THR B 2 20  ? -4.285  -2.577  -8.721  1.00 20.00  ? 21  THR H O   1 
ATOM   1733 C  CB  . THR B 2 20  ? -4.263  -1.965  -11.750 1.00 25.31  ? 21  THR H CB  1 
ATOM   1734 O  OG1 . THR B 2 20  ? -4.202  -1.016  -12.819 1.00 23.12  ? 21  THR H OG1 1 
ATOM   1735 C  CG2 . THR B 2 20  ? -4.856  -3.290  -12.252 1.00 24.92  ? 21  THR H CG2 1 
ATOM   1736 N  N   . CYS B 2 21  ? -6.379  -3.063  -9.437  1.00 14.88  ? 22  CYS H N   1 
ATOM   1737 C  CA  . CYS B 2 21  ? -6.620  -4.170  -8.514  1.00 22.17  ? 22  CYS H CA  1 
ATOM   1738 C  C   . CYS B 2 21  ? -6.674  -5.480  -9.309  1.00 20.39  ? 22  CYS H C   1 
ATOM   1739 O  O   . CYS B 2 21  ? -7.587  -5.688  -10.114 1.00 22.23  ? 22  CYS H O   1 
ATOM   1740 C  CB  . CYS B 2 21  ? -7.927  -3.945  -7.742  1.00 18.93  ? 22  CYS H CB  1 
ATOM   1741 S  SG  . CYS B 2 21  ? -8.452  -5.349  -6.698  1.00 27.13  ? 22  CYS H SG  1 
ATOM   1742 N  N   . LYS B 2 22  ? -5.685  -6.346  -9.104  1.00 18.96  ? 23  LYS H N   1 
ATOM   1743 C  CA  . LYS B 2 22  ? -5.593  -7.617  -9.851  1.00 23.69  ? 23  LYS H CA  1 
ATOM   1744 C  C   . LYS B 2 22  ? -6.069  -8.844  -9.071  1.00 20.57  ? 23  LYS H C   1 
ATOM   1745 O  O   . LYS B 2 22  ? -5.582  -9.129  -7.965  1.00 20.78  ? 23  LYS H O   1 
ATOM   1746 C  CB  . LYS B 2 22  ? -4.155  -7.858  -10.298 1.00 22.40  ? 23  LYS H CB  1 
ATOM   1747 C  CG  . LYS B 2 22  ? -3.914  -9.231  -10.925 1.00 25.73  ? 23  LYS H CG  1 
ATOM   1748 C  CD  . LYS B 2 22  ? -4.455  -9.292  -12.361 1.00 23.72  ? 23  LYS H CD  1 
ATOM   1749 C  CE  . LYS B 2 22  ? -3.930  -10.488 -13.130 1.00 28.72  ? 23  LYS H CE  1 
ATOM   1750 N  NZ  . LYS B 2 22  ? -4.378  -10.449 -14.551 1.00 34.51  ? 23  LYS H NZ  1 
ATOM   1751 N  N   . ALA B 2 23  ? -6.995  -9.592  -9.655  1.00 21.43  ? 24  ALA H N   1 
ATOM   1752 C  CA  . ALA B 2 23  ? -7.531  -10.783 -9.003  1.00 25.97  ? 24  ALA H CA  1 
ATOM   1753 C  C   . ALA B 2 23  ? -6.721  -12.015 -9.391  1.00 30.90  ? 24  ALA H C   1 
ATOM   1754 O  O   . ALA B 2 23  ? -6.312  -12.159 -10.540 1.00 26.52  ? 24  ALA H O   1 
ATOM   1755 C  CB  . ALA B 2 23  ? -8.983  -10.987 -9.360  1.00 20.09  ? 24  ALA H CB  1 
ATOM   1756 N  N   . SER B 2 24  ? -6.489  -12.896 -8.422  1.00 28.46  ? 25  SER H N   1 
ATOM   1757 C  CA  . SER B 2 24  ? -5.835  -14.179 -8.673  1.00 28.74  ? 25  SER H CA  1 
ATOM   1758 C  C   . SER B 2 24  ? -6.654  -15.314 -8.079  1.00 33.19  ? 25  SER H C   1 
ATOM   1759 O  O   . SER B 2 24  ? -7.160  -15.201 -6.963  1.00 27.46  ? 25  SER H O   1 
ATOM   1760 C  CB  . SER B 2 24  ? -4.437  -14.206 -8.058  1.00 27.64  ? 25  SER H CB  1 
ATOM   1761 O  OG  . SER B 2 24  ? -3.566  -13.303 -8.723  1.00 30.98  ? 25  SER H OG  1 
ATOM   1762 N  N   . GLY B 2 25  ? -6.782  -16.410 -8.821  1.00 29.70  ? 26  GLY H N   1 
ATOM   1763 C  CA  . GLY B 2 25  ? -7.512  -17.561 -8.329  1.00 31.28  ? 26  GLY H CA  1 
ATOM   1764 C  C   . GLY B 2 25  ? -9.020  -17.449 -8.443  1.00 37.28  ? 26  GLY H C   1 
ATOM   1765 O  O   . GLY B 2 25  ? -9.727  -18.332 -7.958  1.00 38.73  ? 26  GLY H O   1 
ATOM   1766 N  N   . PHE B 2 26  ? -9.503  -16.377 -9.073  1.00 28.51  ? 27  PHE H N   1 
ATOM   1767 C  CA  . PHE B 2 26  ? -10.919 -16.224 -9.420  1.00 29.81  ? 27  PHE H CA  1 
ATOM   1768 C  C   . PHE B 2 26  ? -11.044 -15.122 -10.481 1.00 23.59  ? 27  PHE H C   1 
ATOM   1769 O  O   . PHE B 2 26  ? -10.039 -14.520 -10.855 1.00 30.09  ? 27  PHE H O   1 
ATOM   1770 C  CB  . PHE B 2 26  ? -11.770 -15.905 -8.184  1.00 26.79  ? 27  PHE H CB  1 
ATOM   1771 C  CG  . PHE B 2 26  ? -11.572 -14.516 -7.644  1.00 32.84  ? 27  PHE H CG  1 
ATOM   1772 C  CD1 . PHE B 2 26  ? -12.551 -13.543 -7.818  1.00 28.26  ? 27  PHE H CD1 1 
ATOM   1773 C  CD2 . PHE B 2 26  ? -10.419 -14.183 -6.945  1.00 30.41  ? 27  PHE H CD2 1 
ATOM   1774 C  CE1 . PHE B 2 26  ? -12.376 -12.272 -7.317  1.00 26.81  ? 27  PHE H CE1 1 
ATOM   1775 C  CE2 . PHE B 2 26  ? -10.245 -12.911 -6.441  1.00 28.23  ? 27  PHE H CE2 1 
ATOM   1776 C  CZ  . PHE B 2 26  ? -11.222 -11.955 -6.630  1.00 26.95  ? 27  PHE H CZ  1 
ATOM   1777 N  N   . SER B 2 27  ? -12.259 -14.856 -10.954 1.00 35.13  ? 28  SER H N   1 
ATOM   1778 C  CA  . SER B 2 27  ? -12.464 -13.842 -11.993 1.00 32.75  ? 28  SER H CA  1 
ATOM   1779 C  C   . SER B 2 27  ? -13.727 -13.007 -11.767 1.00 35.35  ? 28  SER H C   1 
ATOM   1780 O  O   . SER B 2 27  ? -14.630 -13.454 -11.060 1.00 32.89  ? 28  SER H O   1 
ATOM   1781 C  CB  . SER B 2 27  ? -12.540 -14.505 -13.365 1.00 34.99  ? 28  SER H CB  1 
ATOM   1782 O  OG  . SER B 2 27  ? -13.874 -14.869 -13.670 1.00 36.96  ? 28  SER H OG  1 
ATOM   1783 N  N   . PHE B 2 28  ? -13.782 -11.820 -12.393 1.00 31.18  ? 29  PHE H N   1 
ATOM   1784 C  CA  . PHE B 2 28  ? -14.869 -10.854 -12.183 1.00 31.18  ? 29  PHE H CA  1 
ATOM   1785 C  C   . PHE B 2 28  ? -16.107 -11.152 -13.009 1.00 33.82  ? 29  PHE H C   1 
ATOM   1786 O  O   . PHE B 2 28  ? -17.029 -10.342 -13.076 1.00 36.19  ? 29  PHE H O   1 
ATOM   1787 C  CB  . PHE B 2 28  ? -14.383 -9.424  -12.456 1.00 30.85  ? 29  PHE H CB  1 
ATOM   1788 C  CG  . PHE B 2 28  ? -13.354 -8.954  -11.482 1.00 29.22  ? 29  PHE H CG  1 
ATOM   1789 C  CD1 . PHE B 2 28  ? -12.242 -8.256  -11.908 1.00 27.90  ? 29  PHE H CD1 1 
ATOM   1790 C  CD2 . PHE B 2 28  ? -13.492 -9.233  -10.139 1.00 26.98  ? 29  PHE H CD2 1 
ATOM   1791 C  CE1 . PHE B 2 28  ? -11.280 -7.839  -11.010 1.00 27.72  ? 29  PHE H CE1 1 
ATOM   1792 C  CE2 . PHE B 2 28  ? -12.544 -8.810  -9.230  1.00 22.94  ? 29  PHE H CE2 1 
ATOM   1793 C  CZ  . PHE B 2 28  ? -11.434 -8.112  -9.665  1.00 31.65  ? 29  PHE H CZ  1 
ATOM   1794 N  N   . GLY B 2 29  ? -16.124 -12.324 -13.636 1.00 38.06  ? 30  GLY H N   1 
ATOM   1795 C  CA  . GLY B 2 29  ? -17.308 -12.781 -14.336 1.00 38.05  ? 30  GLY H CA  1 
ATOM   1796 C  C   . GLY B 2 29  ? -18.397 -13.221 -13.367 1.00 37.31  ? 30  GLY H C   1 
ATOM   1797 O  O   . GLY B 2 29  ? -19.566 -13.359 -13.753 1.00 43.68  ? 30  GLY H O   1 
ATOM   1798 N  N   . ASN B 2 30  ? -18.020 -13.462 -12.111 1.00 33.59  ? 31  ASN H N   1 
ATOM   1799 C  CA  . ASN B 2 30  ? -19.011 -13.741 -11.064 1.00 34.01  ? 31  ASN H CA  1 
ATOM   1800 C  C   . ASN B 2 30  ? -19.447 -12.455 -10.357 1.00 33.97  ? 31  ASN H C   1 
ATOM   1801 O  O   . ASN B 2 30  ? -18.879 -11.396 -10.610 1.00 37.62  ? 31  ASN H O   1 
ATOM   1802 C  CB  . ASN B 2 30  ? -18.453 -14.730 -10.049 1.00 38.00  ? 31  ASN H CB  1 
ATOM   1803 C  CG  . ASN B 2 30  ? -18.171 -16.081 -10.657 1.00 47.67  ? 31  ASN H CG  1 
ATOM   1804 O  OD1 . ASN B 2 30  ? -19.087 -16.884 -10.866 1.00 52.91  ? 31  ASN H OD1 1 
ATOM   1805 N  ND2 . ASN B 2 30  ? -16.901 -16.344 -10.952 1.00 40.98  ? 31  ASN H ND2 1 
ATOM   1806 N  N   . ASN B 2 31  ? -20.436 -12.549 -9.469  1.00 29.55  ? 32  ASN H N   1 
ATOM   1807 C  CA  . ASN B 2 31  ? -21.024 -11.362 -8.840  1.00 32.51  ? 32  ASN H CA  1 
ATOM   1808 C  C   . ASN B 2 31  ? -20.355 -10.943 -7.524  1.00 36.20  ? 32  ASN H C   1 
ATOM   1809 O  O   . ASN B 2 31  ? -20.468 -11.644 -6.522  1.00 34.35  ? 32  ASN H O   1 
ATOM   1810 C  CB  . ASN B 2 31  ? -22.507 -11.596 -8.581  1.00 36.59  ? 32  ASN H CB  1 
ATOM   1811 C  CG  . ASN B 2 31  ? -23.199 -12.281 -9.733  1.00 50.87  ? 32  ASN H CG  1 
ATOM   1812 O  OD1 . ASN B 2 31  ? -22.910 -12.005 -10.900 1.00 45.16  ? 32  ASN H OD1 1 
ATOM   1813 N  ND2 . ASN B 2 31  ? -24.121 -13.190 -9.414  1.00 54.02  ? 32  ASN H ND2 1 
ATOM   1814 N  N   . TYR B 2 32  ? -19.679 -9.797  -7.523  1.00 19.60  ? 33  TYR H N   1 
ATOM   1815 C  CA  . TYR B 2 32  ? -19.011 -9.296  -6.321  1.00 21.82  ? 33  TYR H CA  1 
ATOM   1816 C  C   . TYR B 2 32  ? -19.185 -7.784  -6.245  1.00 21.45  ? 33  TYR H C   1 
ATOM   1817 O  O   . TYR B 2 32  ? -19.448 -7.139  -7.255  1.00 21.66  ? 33  TYR H O   1 
ATOM   1818 C  CB  . TYR B 2 32  ? -17.502 -9.600  -6.357  1.00 21.08  ? 33  TYR H CB  1 
ATOM   1819 C  CG  . TYR B 2 32  ? -17.153 -11.052 -6.542  1.00 26.08  ? 33  TYR H CG  1 
ATOM   1820 C  CD1 . TYR B 2 32  ? -17.441 -11.984 -5.554  1.00 25.65  ? 33  TYR H CD1 1 
ATOM   1821 C  CD2 . TYR B 2 32  ? -16.537 -11.495 -7.708  1.00 28.43  ? 33  TYR H CD2 1 
ATOM   1822 C  CE1 . TYR B 2 32  ? -17.131 -13.326 -5.720  1.00 30.75  ? 33  TYR H CE1 1 
ATOM   1823 C  CE2 . TYR B 2 32  ? -16.214 -12.843 -7.884  1.00 30.39  ? 33  TYR H CE2 1 
ATOM   1824 C  CZ  . TYR B 2 32  ? -16.518 -13.750 -6.888  1.00 35.77  ? 33  TYR H CZ  1 
ATOM   1825 O  OH  . TYR B 2 32  ? -16.201 -15.082 -7.068  1.00 33.88  ? 33  TYR H OH  1 
ATOM   1826 N  N   . ASP B 2 33  ? -19.038 -7.223  -5.052  1.00 15.24  ? 34  ASP H N   1 
ATOM   1827 C  CA  . ASP B 2 33  ? -18.931 -5.770  -4.901  1.00 18.09  ? 34  ASP H CA  1 
ATOM   1828 C  C   . ASP B 2 33  ? -17.442 -5.442  -4.718  1.00 16.66  ? 34  ASP H C   1 
ATOM   1829 O  O   . ASP B 2 33  ? -16.869 -5.688  -3.652  1.00 17.69  ? 34  ASP H O   1 
ATOM   1830 C  CB  . ASP B 2 33  ? -19.736 -5.313  -3.684  1.00 20.87  ? 34  ASP H CB  1 
ATOM   1831 C  CG  . ASP B 2 33  ? -20.421 -3.961  -3.888  1.00 25.48  ? 34  ASP H CG  1 
ATOM   1832 O  OD1 . ASP B 2 33  ? -21.318 -3.633  -3.087  1.00 21.87  ? 34  ASP H OD1 1 
ATOM   1833 O  OD2 . ASP B 2 33  ? -20.084 -3.225  -4.838  1.00 25.23  ? 34  ASP H OD2 1 
ATOM   1834 N  N   . MET B 2 34  ? -16.801 -4.914  -5.762  1.00 18.21  ? 35  MET H N   1 
ATOM   1835 C  CA  . MET B 2 34  ? -15.369 -4.598  -5.705  1.00 11.23  ? 35  MET H CA  1 
ATOM   1836 C  C   . MET B 2 34  ? -15.205 -3.133  -5.330  1.00 15.57  ? 35  MET H C   1 
ATOM   1837 O  O   . MET B 2 34  ? -15.631 -2.250  -6.078  1.00 15.66  ? 35  MET H O   1 
ATOM   1838 C  CB  . MET B 2 34  ? -14.702 -4.869  -7.048  1.00 15.51  ? 35  MET H CB  1 
ATOM   1839 C  CG  . MET B 2 34  ? -14.758 -6.340  -7.481  1.00 17.94  ? 35  MET H CG  1 
ATOM   1840 S  SD  . MET B 2 34  ? -14.035 -7.461  -6.242  1.00 19.33  ? 35  MET H SD  1 
ATOM   1841 C  CE  . MET B 2 34  ? -12.358 -6.833  -6.167  1.00 15.69  ? 35  MET H CE  1 
ATOM   1842 N  N   . CYS B 2 35  A -14.595 -2.869  -4.179  1.00 14.84  ? 35  CYS H N   1 
ATOM   1843 C  CA  . CYS B 2 35  A -14.586 -1.517  -3.648  1.00 16.17  ? 35  CYS H CA  1 
ATOM   1844 C  C   . CYS B 2 35  A -13.180 -1.034  -3.341  1.00 20.79  ? 35  CYS H C   1 
ATOM   1845 O  O   . CYS B 2 35  A -12.275 -1.844  -3.103  1.00 20.16  ? 35  CYS H O   1 
ATOM   1846 C  CB  . CYS B 2 35  A -15.472 -1.427  -2.391  1.00 14.79  ? 35  CYS H CB  1 
ATOM   1847 S  SG  . CYS B 2 35  A -17.190 -2.053  -2.597  1.00 19.83  ? 35  CYS H SG  1 
ATOM   1848 N  N   . TRP B 2 36  ? -13.000 0.289   -3.345  1.00 16.71  ? 36  TRP H N   1 
ATOM   1849 C  CA  . TRP B 2 36  ? -11.726 0.889   -2.968  1.00 12.14  ? 36  TRP H CA  1 
ATOM   1850 C  C   . TRP B 2 36  ? -11.891 1.658   -1.649  1.00 18.10  ? 36  TRP H C   1 
ATOM   1851 O  O   . TRP B 2 36  ? -12.893 2.350   -1.429  1.00 14.89  ? 36  TRP H O   1 
ATOM   1852 C  CB  . TRP B 2 36  ? -11.218 1.828   -4.068  1.00 18.92  ? 36  TRP H CB  1 
ATOM   1853 C  CG  . TRP B 2 36  ? -10.651 1.131   -5.314  1.00 16.65  ? 36  TRP H CG  1 
ATOM   1854 C  CD1 . TRP B 2 36  ? -11.344 0.785   -6.446  1.00 15.26  ? 36  TRP H CD1 1 
ATOM   1855 C  CD2 . TRP B 2 36  ? -9.281  0.738   -5.548  1.00 14.50  ? 36  TRP H CD2 1 
ATOM   1856 N  NE1 . TRP B 2 36  ? -10.494 0.197   -7.358  1.00 22.19  ? 36  TRP H NE1 1 
ATOM   1857 C  CE2 . TRP B 2 36  ? -9.227  0.157   -6.831  1.00 15.55  ? 36  TRP H CE2 1 
ATOM   1858 C  CE3 . TRP B 2 36  ? -8.104  0.823   -4.793  1.00 16.68  ? 36  TRP H CE3 1 
ATOM   1859 C  CZ2 . TRP B 2 36  ? -8.034  -0.340  -7.386  1.00 18.97  ? 36  TRP H CZ2 1 
ATOM   1860 C  CZ3 . TRP B 2 36  ? -6.912  0.335   -5.342  1.00 18.20  ? 36  TRP H CZ3 1 
ATOM   1861 C  CH2 . TRP B 2 36  ? -6.891  -0.250  -6.625  1.00 19.21  ? 36  TRP H CH2 1 
ATOM   1862 N  N   . VAL B 2 37  ? -10.908 1.501   -0.772  1.00 15.28  ? 37  VAL H N   1 
ATOM   1863 C  CA  . VAL B 2 37  ? -10.880 2.137   0.543   1.00 15.42  ? 37  VAL H CA  1 
ATOM   1864 C  C   . VAL B 2 37  ? -9.490  2.731   0.733   1.00 14.41  ? 37  VAL H C   1 
ATOM   1865 O  O   . VAL B 2 37  ? -8.501  2.078   0.387   1.00 17.58  ? 37  VAL H O   1 
ATOM   1866 C  CB  . VAL B 2 37  ? -11.126 1.089   1.663   1.00 17.35  ? 37  VAL H CB  1 
ATOM   1867 C  CG1 . VAL B 2 37  ? -10.894 1.689   3.066   1.00 16.51  ? 37  VAL H CG1 1 
ATOM   1868 C  CG2 . VAL B 2 37  ? -12.555 0.507   1.554   1.00 15.49  ? 37  VAL H CG2 1 
ATOM   1869 N  N   . ARG B 2 38  ? -9.387  3.940   1.293   1.00 14.33  ? 38  ARG H N   1 
ATOM   1870 C  CA  . ARG B 2 38  ? -8.044  4.501   1.542   1.00 16.72  ? 38  ARG H CA  1 
ATOM   1871 C  C   . ARG B 2 38  ? -7.793  4.867   3.010   1.00 17.29  ? 38  ARG H C   1 
ATOM   1872 O  O   . ARG B 2 38  ? -8.722  4.954   3.813   1.00 15.46  ? 38  ARG H O   1 
ATOM   1873 C  CB  . ARG B 2 38  ? -7.776  5.712   0.628   1.00 16.92  ? 38  ARG H CB  1 
ATOM   1874 C  CG  . ARG B 2 38  ? -8.508  6.973   1.051   1.00 15.30  ? 38  ARG H CG  1 
ATOM   1875 C  CD  . ARG B 2 38  ? -8.223  8.159   0.110   1.00 16.53  ? 38  ARG H CD  1 
ATOM   1876 N  NE  . ARG B 2 38  ? -8.963  9.353   0.547   1.00 19.80  ? 38  ARG H NE  1 
ATOM   1877 C  CZ  . ARG B 2 38  ? -8.979  10.513  -0.104  1.00 21.08  ? 38  ARG H CZ  1 
ATOM   1878 N  NH1 . ARG B 2 38  ? -8.300  10.648  -1.234  1.00 17.00  ? 38  ARG H NH1 1 
ATOM   1879 N  NH2 . ARG B 2 38  ? -9.682  11.540  0.375   1.00 20.33  ? 38  ARG H NH2 1 
ATOM   1880 N  N   . GLN B 2 39  ? -6.526  5.094   3.346   1.00 16.19  ? 39  GLN H N   1 
ATOM   1881 C  CA  . GLN B 2 39  ? -6.116  5.361   4.728   1.00 18.25  ? 39  GLN H CA  1 
ATOM   1882 C  C   . GLN B 2 39  ? -4.896  6.289   4.726   1.00 19.40  ? 39  GLN H C   1 
ATOM   1883 O  O   . GLN B 2 39  ? -3.803  5.878   4.320   1.00 15.62  ? 39  GLN H O   1 
ATOM   1884 C  CB  . GLN B 2 39  ? -5.787  4.044   5.435   1.00 16.48  ? 39  GLN H CB  1 
ATOM   1885 C  CG  . GLN B 2 39  ? -5.312  4.147   6.900   1.00 17.32  ? 39  GLN H CG  1 
ATOM   1886 C  CD  . GLN B 2 39  ? -5.318  2.793   7.621   1.00 17.25  ? 39  GLN H CD  1 
ATOM   1887 O  OE1 . GLN B 2 39  ? -4.808  1.780   7.102   1.00 15.88  ? 39  GLN H OE1 1 
ATOM   1888 N  NE2 . GLN B 2 39  ? -5.912  2.766   8.818   1.00 16.69  ? 39  GLN H NE2 1 
ATOM   1889 N  N   . ALA B 2 40  ? -5.082  7.543   5.144   1.00 17.73  ? 40  ALA H N   1 
ATOM   1890 C  CA  . ALA B 2 40  ? -3.940  8.456   5.259   1.00 19.05  ? 40  ALA H CA  1 
ATOM   1891 C  C   . ALA B 2 40  ? -3.007  8.002   6.396   1.00 22.43  ? 40  ALA H C   1 
ATOM   1892 O  O   . ALA B 2 40  ? -3.456  7.368   7.339   1.00 21.66  ? 40  ALA H O   1 
ATOM   1893 C  CB  . ALA B 2 40  ? -4.402  9.876   5.485   1.00 17.51  ? 40  ALA H CB  1 
ATOM   1894 N  N   . PRO B 2 41  ? -1.706  8.323   6.300   1.00 23.23  ? 41  PRO H N   1 
ATOM   1895 C  CA  . PRO B 2 41  ? -0.761  7.879   7.331   1.00 26.27  ? 41  PRO H CA  1 
ATOM   1896 C  C   . PRO B 2 41  ? -1.220  8.258   8.743   1.00 25.24  ? 41  PRO H C   1 
ATOM   1897 O  O   . PRO B 2 41  ? -1.439  9.432   9.036   1.00 25.25  ? 41  PRO H O   1 
ATOM   1898 C  CB  . PRO B 2 41  ? 0.532   8.615   6.958   1.00 28.68  ? 41  PRO H CB  1 
ATOM   1899 C  CG  . PRO B 2 41  ? 0.441   8.789   5.464   1.00 20.53  ? 41  PRO H CG  1 
ATOM   1900 C  CD  . PRO B 2 41  ? -1.032  9.069   5.216   1.00 23.91  ? 41  PRO H CD  1 
ATOM   1901 N  N   . GLY B 2 42  ? -1.396  7.248   9.591   1.00 28.14  ? 42  GLY H N   1 
ATOM   1902 C  CA  . GLY B 2 42  ? -1.808  7.458   10.969  1.00 29.88  ? 42  GLY H CA  1 
ATOM   1903 C  C   . GLY B 2 42  ? -3.280  7.776   11.177  1.00 31.05  ? 42  GLY H C   1 
ATOM   1904 O  O   . GLY B 2 42  ? -3.679  8.124   12.283  1.00 27.44  ? 42  GLY H O   1 
ATOM   1905 N  N   . LYS B 2 43  ? -4.090  7.645   10.125  1.00 29.08  ? 43  LYS H N   1 
ATOM   1906 C  CA  . LYS B 2 43  ? -5.509  7.993   10.209  1.00 24.32  ? 43  LYS H CA  1 
ATOM   1907 C  C   . LYS B 2 43  ? -6.424  6.782   9.985   1.00 22.90  ? 43  LYS H C   1 
ATOM   1908 O  O   . LYS B 2 43  ? -5.953  5.640   9.914   1.00 20.00  ? 43  LYS H O   1 
ATOM   1909 C  CB  . LYS B 2 43  ? -5.854  9.121   9.217   1.00 24.36  ? 43  LYS H CB  1 
ATOM   1910 C  CG  . LYS B 2 43  ? -5.025  10.395  9.398   1.00 27.28  ? 43  LYS H CG  1 
ATOM   1911 C  CD  . LYS B 2 43  ? -4.961  10.799  10.865  1.00 45.44  ? 43  LYS H CD  1 
ATOM   1912 C  CE  . LYS B 2 43  ? -4.201  12.109  11.066  1.00 58.86  ? 43  LYS H CE  1 
ATOM   1913 N  NZ  . LYS B 2 43  ? -4.101  12.478  12.512  1.00 59.40  ? 43  LYS H NZ  1 
ATOM   1914 N  N   . GLY B 2 44  ? -7.730  7.042   9.874   1.00 16.19  ? 44  GLY H N   1 
ATOM   1915 C  CA  . GLY B 2 44  ? -8.714  5.977   9.794   1.00 19.60  ? 44  GLY H CA  1 
ATOM   1916 C  C   . GLY B 2 44  ? -9.024  5.547   8.370   1.00 24.43  ? 44  GLY H C   1 
ATOM   1917 O  O   . GLY B 2 44  ? -8.503  6.120   7.408   1.00 22.36  ? 44  GLY H O   1 
ATOM   1918 N  N   . LEU B 2 45  ? -9.861  4.522   8.240   1.00 15.55  ? 45  LEU H N   1 
ATOM   1919 C  CA  . LEU B 2 45  ? -10.257 3.995   6.937   1.00 17.76  ? 45  LEU H CA  1 
ATOM   1920 C  C   . LEU B 2 45  ? -11.338 4.900   6.355   1.00 14.51  ? 45  LEU H C   1 
ATOM   1921 O  O   . LEU B 2 45  ? -12.188 5.378   7.094   1.00 17.82  ? 45  LEU H O   1 
ATOM   1922 C  CB  . LEU B 2 45  ? -10.816 2.573   7.101   1.00 13.29  ? 45  LEU H CB  1 
ATOM   1923 C  CG  . LEU B 2 45  ? -9.882  1.472   7.621   1.00 20.11  ? 45  LEU H CG  1 
ATOM   1924 C  CD1 . LEU B 2 45  ? -10.681 0.194   7.874   1.00 19.92  ? 45  LEU H CD1 1 
ATOM   1925 C  CD2 . LEU B 2 45  ? -8.707  1.193   6.654   1.00 12.73  ? 45  LEU H CD2 1 
ATOM   1926 N  N   . GLU B 2 46  ? -11.300 5.122   5.043   1.00 15.16  ? 46  GLU H N   1 
ATOM   1927 C  CA  . GLU B 2 46  ? -12.273 5.973   4.344   1.00 17.80  ? 46  GLU H CA  1 
ATOM   1928 C  C   . GLU B 2 46  ? -12.759 5.311   3.032   1.00 18.48  ? 46  GLU H C   1 
ATOM   1929 O  O   . GLU B 2 46  ? -11.959 4.945   2.179   1.00 17.25  ? 46  GLU H O   1 
ATOM   1930 C  CB  . GLU B 2 46  ? -11.654 7.360   4.066   1.00 14.31  ? 46  GLU H CB  1 
ATOM   1931 C  CG  . GLU B 2 46  ? -12.577 8.377   3.399   1.00 16.91  ? 46  GLU H CG  1 
ATOM   1932 C  CD  . GLU B 2 46  ? -11.927 9.762   3.225   1.00 21.37  ? 46  GLU H CD  1 
ATOM   1933 O  OE1 . GLU B 2 46  ? -10.748 9.853   2.814   1.00 19.78  ? 46  GLU H OE1 1 
ATOM   1934 O  OE2 . GLU B 2 46  ? -12.594 10.766  3.513   1.00 20.80  ? 46  GLU H OE2 1 
ATOM   1935 N  N   . TRP B 2 47  ? -14.070 5.149   2.885   1.00 16.10  ? 47  TRP H N   1 
ATOM   1936 C  CA  . TRP B 2 47  ? -14.633 4.496   1.698   1.00 15.26  ? 47  TRP H CA  1 
ATOM   1937 C  C   . TRP B 2 47  ? -14.539 5.442   0.511   1.00 18.22  ? 47  TRP H C   1 
ATOM   1938 O  O   . TRP B 2 47  ? -14.849 6.627   0.646   1.00 14.77  ? 47  TRP H O   1 
ATOM   1939 C  CB  . TRP B 2 47  ? -16.105 4.150   1.940   1.00 15.00  ? 47  TRP H CB  1 
ATOM   1940 C  CG  . TRP B 2 47  ? -16.778 3.518   0.750   1.00 14.84  ? 47  TRP H CG  1 
ATOM   1941 C  CD1 . TRP B 2 47  ? -16.420 2.353   0.122   1.00 15.43  ? 47  TRP H CD1 1 
ATOM   1942 C  CD2 . TRP B 2 47  ? -17.940 4.001   0.061   1.00 13.91  ? 47  TRP H CD2 1 
ATOM   1943 N  NE1 . TRP B 2 47  ? -17.282 2.093   -0.918  1.00 16.32  ? 47  TRP H NE1 1 
ATOM   1944 C  CE2 . TRP B 2 47  ? -18.226 3.082   -0.975  1.00 14.09  ? 47  TRP H CE2 1 
ATOM   1945 C  CE3 . TRP B 2 47  ? -18.752 5.124   0.206   1.00 16.31  ? 47  TRP H CE3 1 
ATOM   1946 C  CZ2 . TRP B 2 47  ? -19.291 3.258   -1.864  1.00 20.67  ? 47  TRP H CZ2 1 
ATOM   1947 C  CZ3 . TRP B 2 47  ? -19.828 5.292   -0.673  1.00 16.66  ? 47  TRP H CZ3 1 
ATOM   1948 C  CH2 . TRP B 2 47  ? -20.075 4.372   -1.701  1.00 17.00  ? 47  TRP H CH2 1 
ATOM   1949 N  N   . ILE B 2 48  ? -14.132 4.919   -0.645  1.00 14.29  ? 48  ILE H N   1 
ATOM   1950 C  CA  . ILE B 2 48  ? -14.059 5.704   -1.871  1.00 15.68  ? 48  ILE H CA  1 
ATOM   1951 C  C   . ILE B 2 48  ? -15.234 5.430   -2.824  1.00 15.54  ? 48  ILE H C   1 
ATOM   1952 O  O   . ILE B 2 48  ? -15.925 6.354   -3.253  1.00 15.57  ? 48  ILE H O   1 
ATOM   1953 C  CB  . ILE B 2 48  ? -12.740 5.457   -2.639  1.00 17.39  ? 48  ILE H CB  1 
ATOM   1954 C  CG1 . ILE B 2 48  ? -11.525 5.830   -1.769  1.00 15.25  ? 48  ILE H CG1 1 
ATOM   1955 C  CG2 . ILE B 2 48  ? -12.747 6.266   -3.950  1.00 17.87  ? 48  ILE H CG2 1 
ATOM   1956 C  CD1 . ILE B 2 48  ? -10.193 5.398   -2.360  1.00 17.33  ? 48  ILE H CD1 1 
ATOM   1957 N  N   . GLY B 2 49  ? -15.447 4.159   -3.163  1.00 15.75  ? 49  GLY H N   1 
ATOM   1958 C  CA  . GLY B 2 49  ? -16.538 3.786   -4.052  1.00 16.99  ? 49  GLY H CA  1 
ATOM   1959 C  C   . GLY B 2 49  ? -16.524 2.298   -4.352  1.00 17.48  ? 49  GLY H C   1 
ATOM   1960 O  O   . GLY B 2 49  ? -15.643 1.592   -3.866  1.00 15.74  ? 49  GLY H O   1 
ATOM   1961 N  N   . CYS B 2 50  ? -17.493 1.830   -5.140  1.00 16.86  ? 50  CYS H N   1 
ATOM   1962 C  CA  . CYS B 2 50  ? -17.599 0.406   -5.517  1.00 19.68  ? 50  CYS H CA  1 
ATOM   1963 C  C   . CYS B 2 50  ? -18.047 0.226   -6.969  1.00 22.36  ? 50  CYS H C   1 
ATOM   1964 O  O   . CYS B 2 50  ? -18.706 1.092   -7.540  1.00 18.72  ? 50  CYS H O   1 
ATOM   1965 C  CB  . CYS B 2 50  ? -18.646 -0.328  -4.655  1.00 19.81  ? 50  CYS H CB  1 
ATOM   1966 S  SG  . CYS B 2 50  ? -18.381 -0.431  -2.843  1.00 21.83  ? 50  CYS H SG  1 
ATOM   1967 N  N   . ILE B 2 51  ? -17.714 -0.930  -7.537  1.00 21.02  ? 51  ILE H N   1 
ATOM   1968 C  CA  . ILE B 2 51  ? -18.327 -1.402  -8.776  1.00 23.76  ? 51  ILE H CA  1 
ATOM   1969 C  C   . ILE B 2 51  ? -18.814 -2.849  -8.579  1.00 19.97  ? 51  ILE H C   1 
ATOM   1970 O  O   . ILE B 2 51  ? -18.066 -3.689  -8.097  1.00 17.24  ? 51  ILE H O   1 
ATOM   1971 C  CB  . ILE B 2 51  ? -17.339 -1.316  -9.982  1.00 18.05  ? 51  ILE H CB  1 
ATOM   1972 C  CG1 . ILE B 2 51  ? -18.008 -1.815  -11.264 1.00 22.17  ? 51  ILE H CG1 1 
ATOM   1973 C  CG2 . ILE B 2 51  ? -16.031 -2.094  -9.742  1.00 19.48  ? 51  ILE H CG2 1 
ATOM   1974 C  CD1 . ILE B 2 51  ? -18.645 -0.726  -12.052 1.00 21.44  ? 51  ILE H CD1 1 
ATOM   1975 N  N   . GLU B 2 52  ? -20.075 -3.120  -8.915  1.00 17.33  ? 52  GLU H N   1 
ATOM   1976 C  CA  . GLU B 2 52  ? -20.610 -4.482  -8.924  1.00 22.97  ? 52  GLU H CA  1 
ATOM   1977 C  C   . GLU B 2 52  ? -20.162 -5.184  -10.182 1.00 25.29  ? 52  GLU H C   1 
ATOM   1978 O  O   . GLU B 2 52  ? -20.252 -4.624  -11.270 1.00 25.12  ? 52  GLU H O   1 
ATOM   1979 C  CB  . GLU B 2 52  ? -22.132 -4.476  -8.971  1.00 28.31  ? 52  GLU H CB  1 
ATOM   1980 C  CG  . GLU B 2 52  ? -22.843 -4.082  -7.718  1.00 30.02  ? 52  GLU H CG  1 
ATOM   1981 C  CD  . GLU B 2 52  ? -24.341 -4.187  -7.899  1.00 44.16  ? 52  GLU H CD  1 
ATOM   1982 O  OE1 . GLU B 2 52  ? -24.845 -3.710  -8.950  1.00 42.52  ? 52  GLU H OE1 1 
ATOM   1983 O  OE2 . GLU B 2 52  ? -24.997 -4.777  -7.015  1.00 42.04  ? 52  GLU H OE2 1 
ATOM   1984 N  N   . THR B 2 53  A -19.725 -6.426  -10.057 1.00 21.69  ? 52  THR H N   1 
ATOM   1985 C  CA  . THR B 2 53  A -19.284 -7.153  -11.239 1.00 24.92  ? 52  THR H CA  1 
ATOM   1986 C  C   . THR B 2 53  A -20.363 -8.103  -11.766 1.00 38.52  ? 52  THR H C   1 
ATOM   1987 O  O   . THR B 2 53  A -20.143 -8.835  -12.734 1.00 41.67  ? 52  THR H O   1 
ATOM   1988 C  CB  . THR B 2 53  A -17.986 -7.917  -10.965 1.00 32.99  ? 52  THR H CB  1 
ATOM   1989 O  OG1 . THR B 2 53  A -18.220 -8.901  -9.949  1.00 29.84  ? 52  THR H OG1 1 
ATOM   1990 C  CG2 . THR B 2 53  A -16.915 -6.951  -10.497 1.00 26.76  ? 52  THR H CG2 1 
ATOM   1991 N  N   . GLY B 2 54  B -21.525 -8.086  -11.120 1.00 32.29  ? 52  GLY H N   1 
ATOM   1992 C  CA  . GLY B 2 54  B -22.699 -8.787  -11.620 1.00 50.67  ? 52  GLY H CA  1 
ATOM   1993 C  C   . GLY B 2 54  B -23.683 -7.877  -12.336 1.00 48.77  ? 52  GLY H C   1 
ATOM   1994 O  O   . GLY B 2 54  B -23.370 -6.711  -12.635 1.00 43.18  ? 52  GLY H O   1 
ATOM   1995 N  N   . SER B 2 55  ? -24.877 -8.410  -12.601 1.00 39.16  ? 53  SER H N   1 
ATOM   1996 C  CA  . SER B 2 55  ? -25.906 -7.647  -13.295 1.00 49.00  ? 53  SER H CA  1 
ATOM   1997 C  C   . SER B 2 55  ? -26.195 -6.369  -12.518 1.00 48.38  ? 53  SER H C   1 
ATOM   1998 O  O   . SER B 2 55  ? -25.912 -6.292  -11.315 1.00 49.77  ? 53  SER H O   1 
ATOM   1999 C  CB  . SER B 2 55  ? -27.182 -8.469  -13.505 1.00 55.41  ? 53  SER H CB  1 
ATOM   2000 O  OG  . SER B 2 55  ? -28.002 -8.466  -12.348 1.00 66.84  ? 53  SER H OG  1 
ATOM   2001 N  N   . SER B 2 56  ? -26.763 -5.390  -13.223 1.00 56.59  ? 54  SER H N   1 
ATOM   2002 C  CA  . SER B 2 56  ? -26.818 -3.974  -12.811 1.00 51.72  ? 54  SER H CA  1 
ATOM   2003 C  C   . SER B 2 56  ? -25.489 -3.227  -13.044 1.00 47.67  ? 54  SER H C   1 
ATOM   2004 O  O   . SER B 2 56  ? -25.523 -2.060  -13.457 1.00 43.59  ? 54  SER H O   1 
ATOM   2005 C  CB  . SER B 2 56  ? -27.384 -3.744  -11.389 1.00 52.70  ? 54  SER H CB  1 
ATOM   2006 O  OG  . SER B 2 56  ? -26.442 -4.036  -10.362 1.00 45.32  ? 54  SER H OG  1 
ATOM   2007 N  N   . ASP B 2 57  ? -24.346 -3.908  -12.839 1.00 33.52  ? 55  ASP H N   1 
ATOM   2008 C  CA  . ASP B 2 57  ? -23.010 -3.307  -13.013 1.00 33.01  ? 55  ASP H CA  1 
ATOM   2009 C  C   . ASP B 2 57  ? -22.950 -1.870  -12.502 1.00 24.30  ? 55  ASP H C   1 
ATOM   2010 O  O   . ASP B 2 57  ? -22.487 -0.957  -13.193 1.00 23.30  ? 55  ASP H O   1 
ATOM   2011 C  CB  . ASP B 2 57  ? -22.537 -3.350  -14.468 1.00 30.54  ? 55  ASP H CB  1 
ATOM   2012 C  CG  . ASP B 2 57  ? -23.610 -3.794  -15.424 1.00 44.84  ? 55  ASP H CG  1 
ATOM   2013 O  OD1 . ASP B 2 57  ? -23.624 -5.000  -15.757 1.00 39.95  ? 55  ASP H OD1 1 
ATOM   2014 O  OD2 . ASP B 2 57  ? -24.431 -2.941  -15.843 1.00 40.69  ? 55  ASP H OD2 1 
ATOM   2015 N  N   . SER B 2 58  ? -23.442 -1.688  -11.287 1.00 18.86  ? 56  SER H N   1 
ATOM   2016 C  CA  . SER B 2 58  ? -23.573 -0.366  -10.721 1.00 22.48  ? 56  SER H CA  1 
ATOM   2017 C  C   . SER B 2 58  ? -22.262 0.131   -10.125 1.00 19.16  ? 56  SER H C   1 
ATOM   2018 O  O   . SER B 2 58  ? -21.656 -0.552  -9.320  1.00 18.01  ? 56  SER H O   1 
ATOM   2019 C  CB  . SER B 2 58  ? -24.649 -0.369  -9.642  1.00 21.46  ? 56  SER H CB  1 
ATOM   2020 O  OG  . SER B 2 58  ? -24.553 0.805   -8.857  1.00 22.51  ? 56  SER H OG  1 
ATOM   2021 N  N   . ALA B 2 59  ? -21.872 1.342   -10.516 1.00 19.65  ? 57  ALA H N   1 
ATOM   2022 C  CA  . ALA B 2 59  ? -20.804 2.104   -9.864  1.00 18.80  ? 57  ALA H CA  1 
ATOM   2023 C  C   . ALA B 2 59  ? -21.427 3.121   -8.904  1.00 17.17  ? 57  ALA H C   1 
ATOM   2024 O  O   . ALA B 2 59  ? -22.394 3.781   -9.255  1.00 18.49  ? 57  ALA H O   1 
ATOM   2025 C  CB  . ALA B 2 59  ? -19.950 2.844   -10.930 1.00 15.79  ? 57  ALA H CB  1 
ATOM   2026 N  N   . ALA B 2 60  ? -20.870 3.246   -7.702  1.00 16.01  ? 58  ALA H N   1 
ATOM   2027 C  CA  . ALA B 2 60  ? -21.347 4.231   -6.713  1.00 15.37  ? 58  ALA H CA  1 
ATOM   2028 C  C   . ALA B 2 60  ? -20.152 4.810   -5.967  1.00 18.73  ? 58  ALA H C   1 
ATOM   2029 O  O   . ALA B 2 60  ? -19.155 4.120   -5.776  1.00 14.88  ? 58  ALA H O   1 
ATOM   2030 C  CB  . ALA B 2 60  ? -22.314 3.592   -5.723  1.00 17.02  ? 58  ALA H CB  1 
ATOM   2031 N  N   . TYR B 2 61  ? -20.270 6.062   -5.516  1.00 21.47  ? 59  TYR H N   1 
ATOM   2032 C  CA  . TYR B 2 61  ? -19.138 6.775   -4.924  1.00 16.97  ? 59  TYR H CA  1 
ATOM   2033 C  C   . TYR B 2 61  ? -19.506 7.500   -3.632  1.00 22.66  ? 59  TYR H C   1 
ATOM   2034 O  O   . TYR B 2 61  ? -20.674 7.847   -3.409  1.00 15.61  ? 59  TYR H O   1 
ATOM   2035 C  CB  . TYR B 2 61  ? -18.597 7.804   -5.947  1.00 15.43  ? 59  TYR H CB  1 
ATOM   2036 C  CG  . TYR B 2 61  ? -18.189 7.163   -7.263  1.00 19.19  ? 59  TYR H CG  1 
ATOM   2037 C  CD1 . TYR B 2 61  ? -19.105 7.006   -8.305  1.00 15.37  ? 59  TYR H CD1 1 
ATOM   2038 C  CD2 . TYR B 2 61  ? -16.899 6.672   -7.445  1.00 15.35  ? 59  TYR H CD2 1 
ATOM   2039 C  CE1 . TYR B 2 61  ? -18.735 6.382   -9.501  1.00 16.98  ? 59  TYR H CE1 1 
ATOM   2040 C  CE2 . TYR B 2 61  ? -16.522 6.052   -8.625  1.00 15.96  ? 59  TYR H CE2 1 
ATOM   2041 C  CZ  . TYR B 2 61  ? -17.438 5.913   -9.652  1.00 16.06  ? 59  TYR H CZ  1 
ATOM   2042 O  OH  . TYR B 2 61  ? -17.030 5.309   -10.820 1.00 15.66  ? 59  TYR H OH  1 
ATOM   2043 N  N   . ALA B 2 62  ? -18.509 7.737   -2.778  1.00 17.42  ? 60  ALA H N   1 
ATOM   2044 C  CA  . ALA B 2 62  ? -18.688 8.678   -1.680  1.00 17.07  ? 60  ALA H CA  1 
ATOM   2045 C  C   . ALA B 2 62  ? -18.932 10.072  -2.276  1.00 16.40  ? 60  ALA H C   1 
ATOM   2046 O  O   . ALA B 2 62  ? -18.405 10.412  -3.340  1.00 16.16  ? 60  ALA H O   1 
ATOM   2047 C  CB  . ALA B 2 62  ? -17.455 8.685   -0.754  1.00 14.06  ? 60  ALA H CB  1 
ATOM   2048 N  N   . THR B 2 63  ? -19.724 10.890  -1.597  1.00 22.69  ? 61  THR H N   1 
ATOM   2049 C  CA  . THR B 2 63  ? -20.001 12.228  -2.121  1.00 19.52  ? 61  THR H CA  1 
ATOM   2050 C  C   . THR B 2 63  ? -18.710 13.003  -2.436  1.00 18.17  ? 61  THR H C   1 
ATOM   2051 O  O   . THR B 2 63  ? -18.608 13.652  -3.489  1.00 18.03  ? 61  THR H O   1 
ATOM   2052 C  CB  . THR B 2 63  ? -20.927 13.035  -1.189  1.00 26.32  ? 61  THR H CB  1 
ATOM   2053 O  OG1 . THR B 2 63  ? -22.250 12.475  -1.251  1.00 20.24  ? 61  THR H OG1 1 
ATOM   2054 C  CG2 . THR B 2 63  ? -20.974 14.516  -1.623  1.00 20.27  ? 61  THR H CG2 1 
ATOM   2055 N  N   . TRP B 2 64  ? -17.705 12.905  -1.565  1.00 19.28  ? 62  TRP H N   1 
ATOM   2056 C  CA  . TRP B 2 64  ? -16.463 13.653  -1.790  1.00 19.60  ? 62  TRP H CA  1 
ATOM   2057 C  C   . TRP B 2 64  ? -15.731 13.227  -3.064  1.00 23.83  ? 62  TRP H C   1 
ATOM   2058 O  O   . TRP B 2 64  ? -15.076 14.063  -3.706  1.00 25.09  ? 62  TRP H O   1 
ATOM   2059 C  CB  . TRP B 2 64  ? -15.508 13.609  -0.568  1.00 20.35  ? 62  TRP H CB  1 
ATOM   2060 C  CG  . TRP B 2 64  ? -14.997 12.249  -0.240  1.00 19.58  ? 62  TRP H CG  1 
ATOM   2061 C  CD1 . TRP B 2 64  ? -15.521 11.373  0.665   1.00 16.54  ? 62  TRP H CD1 1 
ATOM   2062 C  CD2 . TRP B 2 64  ? -13.865 11.596  -0.828  1.00 19.31  ? 62  TRP H CD2 1 
ATOM   2063 N  NE1 . TRP B 2 64  ? -14.791 10.202  0.667   1.00 17.11  ? 62  TRP H NE1 1 
ATOM   2064 C  CE2 . TRP B 2 64  ? -13.763 10.320  -0.230  1.00 16.69  ? 62  TRP H CE2 1 
ATOM   2065 C  CE3 . TRP B 2 64  ? -12.927 11.958  -1.800  1.00 18.50  ? 62  TRP H CE3 1 
ATOM   2066 C  CZ2 . TRP B 2 64  ? -12.761 9.408   -0.574  1.00 15.26  ? 62  TRP H CZ2 1 
ATOM   2067 C  CZ3 . TRP B 2 64  ? -11.922 11.054  -2.130  1.00 20.57  ? 62  TRP H CZ3 1 
ATOM   2068 C  CH2 . TRP B 2 64  ? -11.855 9.791   -1.523  1.00 18.17  ? 62  TRP H CH2 1 
ATOM   2069 N  N   . ALA B 2 65  ? -15.841 11.948  -3.430  1.00 17.63  ? 63  ALA H N   1 
ATOM   2070 C  CA  . ALA B 2 65  ? -15.150 11.397  -4.607  1.00 15.22  ? 63  ALA H CA  1 
ATOM   2071 C  C   . ALA B 2 65  ? -15.910 11.540  -5.935  1.00 14.72  ? 63  ALA H C   1 
ATOM   2072 O  O   . ALA B 2 65  ? -15.307 11.495  -7.014  1.00 19.65  ? 63  ALA H O   1 
ATOM   2073 C  CB  . ALA B 2 65  ? -14.841 9.926   -4.368  1.00 18.43  ? 63  ALA H CB  1 
ATOM   2074 N  N   . LYS B 2 66  ? -17.230 11.660  -5.845  1.00 16.38  ? 64  LYS H N   1 
ATOM   2075 C  CA  . LYS B 2 66  ? -18.115 11.567  -7.010  1.00 13.99  ? 64  LYS H CA  1 
ATOM   2076 C  C   . LYS B 2 66  ? -17.745 12.619  -8.030  1.00 15.63  ? 64  LYS H C   1 
ATOM   2077 O  O   . LYS B 2 66  ? -17.632 13.799  -7.688  1.00 13.28  ? 64  LYS H O   1 
ATOM   2078 C  CB  . LYS B 2 66  ? -19.563 11.767  -6.565  1.00 16.97  ? 64  LYS H CB  1 
ATOM   2079 C  CG  . LYS B 2 66  ? -20.595 11.653  -7.677  1.00 19.84  ? 64  LYS H CG  1 
ATOM   2080 C  CD  . LYS B 2 66  ? -22.001 11.958  -7.143  1.00 20.54  ? 64  LYS H CD  1 
ATOM   2081 C  CE  . LYS B 2 66  ? -22.982 12.159  -8.281  1.00 27.52  ? 64  LYS H CE  1 
ATOM   2082 N  NZ  . LYS B 2 66  ? -24.356 12.456  -7.822  1.00 24.66  ? 64  LYS H NZ  1 
ATOM   2083 N  N   . GLY B 2 67  ? -17.538 12.199  -9.274  1.00 18.21  ? 65  GLY H N   1 
ATOM   2084 C  CA  . GLY B 2 67  ? -17.153 13.118  -10.337 1.00 15.94  ? 65  GLY H CA  1 
ATOM   2085 C  C   . GLY B 2 67  ? -15.653 13.370  -10.485 1.00 17.99  ? 65  GLY H C   1 
ATOM   2086 O  O   . GLY B 2 67  ? -15.204 13.806  -11.541 1.00 19.37  ? 65  GLY H O   1 
ATOM   2087 N  N   . ARG B 2 68  ? -14.869 13.108  -9.440  1.00 20.92  ? 66  ARG H N   1 
ATOM   2088 C  CA  . ARG B 2 68  ? -13.408 13.305  -9.531  1.00 20.17  ? 66  ARG H CA  1 
ATOM   2089 C  C   . ARG B 2 68  ? -12.659 11.987  -9.753  1.00 20.22  ? 66  ARG H C   1 
ATOM   2090 O  O   . ARG B 2 68  ? -11.627 11.965  -10.418 1.00 21.58  ? 66  ARG H O   1 
ATOM   2091 C  CB  . ARG B 2 68  ? -12.858 14.068  -8.297  1.00 21.92  ? 66  ARG H CB  1 
ATOM   2092 C  CG  . ARG B 2 68  ? -11.330 14.398  -8.355  1.00 21.11  ? 66  ARG H CG  1 
ATOM   2093 C  CD  . ARG B 2 68  ? -10.932 15.510  -7.374  1.00 25.76  ? 66  ARG H CD  1 
ATOM   2094 N  NE  . ARG B 2 68  ? -10.993 15.090  -5.977  1.00 20.89  ? 66  ARG H NE  1 
ATOM   2095 C  CZ  . ARG B 2 68  ? -9.952  14.628  -5.285  1.00 24.91  ? 66  ARG H CZ  1 
ATOM   2096 N  NH1 . ARG B 2 68  ? -8.755  14.529  -5.844  1.00 20.07  ? 66  ARG H NH1 1 
ATOM   2097 N  NH2 . ARG B 2 68  ? -10.107 14.272  -4.022  1.00 21.88  ? 66  ARG H NH2 1 
ATOM   2098 N  N   . PHE B 2 69  ? -13.179 10.894  -9.190  1.00 17.88  ? 67  PHE H N   1 
ATOM   2099 C  CA  . PHE B 2 69  ? -12.590 9.564   -9.338  1.00 17.14  ? 67  PHE H CA  1 
ATOM   2100 C  C   . PHE B 2 69  ? -13.536 8.666   -10.144 1.00 20.39  ? 67  PHE H C   1 
ATOM   2101 O  O   . PHE B 2 69  ? -14.753 8.855   -10.094 1.00 19.25  ? 67  PHE H O   1 
ATOM   2102 C  CB  . PHE B 2 69  ? -12.383 8.893   -7.971  1.00 22.30  ? 67  PHE H CB  1 
ATOM   2103 C  CG  . PHE B 2 69  ? -11.336 9.547   -7.094  1.00 24.22  ? 67  PHE H CG  1 
ATOM   2104 C  CD1 . PHE B 2 69  ? -11.032 9.003   -5.858  1.00 22.21  ? 67  PHE H CD1 1 
ATOM   2105 C  CD2 . PHE B 2 69  ? -10.667 10.695  -7.496  1.00 28.32  ? 67  PHE H CD2 1 
ATOM   2106 C  CE1 . PHE B 2 69  ? -10.080 9.580   -5.035  1.00 18.37  ? 67  PHE H CE1 1 
ATOM   2107 C  CE2 . PHE B 2 69  ? -9.705  11.281  -6.678  1.00 26.74  ? 67  PHE H CE2 1 
ATOM   2108 C  CZ  . PHE B 2 69  ? -9.420  10.719  -5.444  1.00 24.77  ? 67  PHE H CZ  1 
ATOM   2109 N  N   . THR B 2 70  ? -12.992 7.684   -10.862 1.00 16.26  ? 68  THR H N   1 
ATOM   2110 C  CA  . THR B 2 70  ? -13.824 6.627   -11.454 1.00 16.69  ? 68  THR H CA  1 
ATOM   2111 C  C   . THR B 2 70  ? -13.337 5.240   -11.052 1.00 17.93  ? 68  THR H C   1 
ATOM   2112 O  O   . THR B 2 70  ? -12.143 5.025   -10.831 1.00 20.63  ? 68  THR H O   1 
ATOM   2113 C  CB  . THR B 2 70  ? -13.858 6.654   -12.998 1.00 16.01  ? 68  THR H CB  1 
ATOM   2114 O  OG1 . THR B 2 70  ? -12.577 6.279   -13.529 1.00 18.79  ? 68  THR H OG1 1 
ATOM   2115 C  CG2 . THR B 2 70  ? -14.271 8.037   -13.530 1.00 18.71  ? 68  THR H CG2 1 
ATOM   2116 N  N   . ILE B 2 71  ? -14.272 4.301   -10.973 1.00 19.82  ? 69  ILE H N   1 
ATOM   2117 C  CA  . ILE B 2 71  ? -13.926 2.904   -10.754 1.00 12.03  ? 69  ILE H CA  1 
ATOM   2118 C  C   . ILE B 2 71  ? -14.517 2.087   -11.899 1.00 18.51  ? 69  ILE H C   1 
ATOM   2119 O  O   . ILE B 2 71  ? -15.696 2.239   -12.228 1.00 16.55  ? 69  ILE H O   1 
ATOM   2120 C  CB  . ILE B 2 71  ? -14.460 2.415   -9.396  1.00 18.91  ? 69  ILE H CB  1 
ATOM   2121 C  CG1 . ILE B 2 71  ? -13.814 3.233   -8.270  1.00 19.00  ? 69  ILE H CG1 1 
ATOM   2122 C  CG2 . ILE B 2 71  ? -14.233 0.899   -9.231  1.00 14.30  ? 69  ILE H CG2 1 
ATOM   2123 C  CD1 . ILE B 2 71  ? -14.439 2.995   -6.881  1.00 22.77  ? 69  ILE H CD1 1 
ATOM   2124 N  N   . SER B 2 72  ? -13.710 1.249   -12.543 1.00 15.96  ? 70  SER H N   1 
ATOM   2125 C  CA  . SER B 2 72  ? -14.269 0.454   -13.629 1.00 19.48  ? 70  SER H CA  1 
ATOM   2126 C  C   . SER B 2 72  ? -13.641 -0.943  -13.757 1.00 25.36  ? 70  SER H C   1 
ATOM   2127 O  O   . SER B 2 72  ? -12.503 -1.163  -13.362 1.00 26.36  ? 70  SER H O   1 
ATOM   2128 C  CB  . SER B 2 72  ? -14.231 1.234   -14.958 1.00 20.59  ? 70  SER H CB  1 
ATOM   2129 O  OG  . SER B 2 72  ? -12.914 1.506   -15.359 1.00 30.23  ? 70  SER H OG  1 
ATOM   2130 N  N   . LYS B 2 73  ? -14.408 -1.886  -14.292 1.00 19.88  ? 71  LYS H N   1 
ATOM   2131 C  CA  . LYS B 2 73  ? -13.919 -3.247  -14.513 1.00 28.05  ? 71  LYS H CA  1 
ATOM   2132 C  C   . LYS B 2 73  ? -13.277 -3.339  -15.881 1.00 32.93  ? 71  LYS H C   1 
ATOM   2133 O  O   . LYS B 2 73  ? -13.972 -3.206  -16.892 1.00 38.25  ? 71  LYS H O   1 
ATOM   2134 C  CB  . LYS B 2 73  ? -15.099 -4.203  -14.444 1.00 23.66  ? 71  LYS H CB  1 
ATOM   2135 C  CG  . LYS B 2 73  ? -14.827 -5.632  -14.860 1.00 38.25  ? 71  LYS H CG  1 
ATOM   2136 C  CD  . LYS B 2 73  ? -16.113 -6.457  -14.721 1.00 30.33  ? 71  LYS H CD  1 
ATOM   2137 C  CE  . LYS B 2 73  ? -17.208 -6.027  -15.718 1.00 37.49  ? 71  LYS H CE  1 
ATOM   2138 N  NZ  . LYS B 2 73  ? -18.512 -6.751  -15.542 1.00 36.11  ? 71  LYS H NZ  1 
ATOM   2139 N  N   . THR B 2 74  ? -11.967 -3.577  -15.926 1.00 25.20  ? 72  THR H N   1 
ATOM   2140 C  CA  . THR B 2 74  ? -11.249 -3.511  -17.193 1.00 24.76  ? 72  THR H CA  1 
ATOM   2141 C  C   . THR B 2 74  ? -10.884 -4.853  -17.861 1.00 26.05  ? 72  THR H C   1 
ATOM   2142 O  O   . THR B 2 74  ? -10.402 -4.872  -18.988 1.00 30.95  ? 72  THR H O   1 
ATOM   2143 C  CB  . THR B 2 74  ? -10.023 -2.592  -17.093 1.00 28.81  ? 72  THR H CB  1 
ATOM   2144 O  OG1 . THR B 2 74  ? -9.049  -3.152  -16.202 1.00 25.56  ? 72  THR H OG1 1 
ATOM   2145 C  CG2 . THR B 2 74  ? -10.435 -1.213  -16.583 1.00 26.16  ? 72  THR H CG2 1 
ATOM   2146 N  N   . SER B 2 75  ? -11.111 -5.955  -17.158 1.00 25.56  ? 73  SER H N   1 
ATOM   2147 C  CA  . SER B 2 75  ? -10.943 -7.304  -17.698 1.00 26.85  ? 73  SER H CA  1 
ATOM   2148 C  C   . SER B 2 75  ? -11.553 -8.239  -16.667 1.00 29.89  ? 73  SER H C   1 
ATOM   2149 O  O   . SER B 2 75  ? -12.006 -7.784  -15.619 1.00 20.49  ? 73  SER H O   1 
ATOM   2150 C  CB  . SER B 2 75  ? -9.469  -7.649  -17.878 1.00 32.98  ? 73  SER H CB  1 
ATOM   2151 O  OG  . SER B 2 75  ? -8.925  -8.114  -16.655 1.00 32.13  ? 73  SER H OG  1 
ATOM   2152 N  N   . SER B 2 76  ? -11.554 -9.541  -16.934 1.00 23.83  ? 74  SER H N   1 
ATOM   2153 C  CA  . SER B 2 76  ? -12.153 -10.480 -15.995 1.00 23.93  ? 74  SER H CA  1 
ATOM   2154 C  C   . SER B 2 76  ? -11.349 -10.588 -14.688 1.00 24.81  ? 74  SER H C   1 
ATOM   2155 O  O   . SER B 2 76  ? -11.837 -11.155 -13.708 1.00 29.02  ? 74  SER H O   1 
ATOM   2156 C  CB  . SER B 2 76  ? -12.310 -11.867 -16.627 1.00 30.23  ? 74  SER H CB  1 
ATOM   2157 O  OG  . SER B 2 76  ? -11.044 -12.420 -16.950 1.00 32.15  ? 74  SER H OG  1 
ATOM   2158 N  N   . THR B 2 77  ? -10.134 -10.044 -14.674 1.00 24.87  ? 75  THR H N   1 
ATOM   2159 C  CA  . THR B 2 77  ? -9.314  -10.054 -13.454 1.00 28.55  ? 75  THR H CA  1 
ATOM   2160 C  C   . THR B 2 77  ? -8.729  -8.692  -13.032 1.00 26.15  ? 75  THR H C   1 
ATOM   2161 O  O   . THR B 2 77  ? -7.856  -8.649  -12.164 1.00 27.61  ? 75  THR H O   1 
ATOM   2162 C  CB  . THR B 2 77  ? -8.131  -11.035 -13.574 1.00 25.72  ? 75  THR H CB  1 
ATOM   2163 O  OG1 . THR B 2 77  ? -7.338  -10.670 -14.706 1.00 28.58  ? 75  THR H OG1 1 
ATOM   2164 C  CG2 . THR B 2 77  ? -8.620  -12.458 -13.737 1.00 29.77  ? 75  THR H CG2 1 
ATOM   2165 N  N   . THR B 2 78  ? -9.182  -7.588  -13.630 1.00 28.35  ? 76  THR H N   1 
ATOM   2166 C  CA  . THR B 2 78  ? -8.674  -6.267  -13.226 1.00 26.61  ? 76  THR H CA  1 
ATOM   2167 C  C   . THR B 2 78  ? -9.785  -5.237  -13.020 1.00 26.45  ? 76  THR H C   1 
ATOM   2168 O  O   . THR B 2 78  ? -10.685 -5.121  -13.847 1.00 21.92  ? 76  THR H O   1 
ATOM   2169 C  CB  . THR B 2 78  ? -7.636  -5.682  -14.230 1.00 27.75  ? 76  THR H CB  1 
ATOM   2170 O  OG1 . THR B 2 78  ? -8.217  -5.599  -15.542 1.00 29.61  ? 76  THR H OG1 1 
ATOM   2171 C  CG2 . THR B 2 78  ? -6.365  -6.531  -14.271 1.00 26.39  ? 76  THR H CG2 1 
ATOM   2172 N  N   . VAL B 2 79  ? -9.703  -4.495  -11.915 1.00 22.54  ? 77  VAL H N   1 
ATOM   2173 C  CA  . VAL B 2 79  ? -10.534 -3.307  -11.673 1.00 16.68  ? 77  VAL H CA  1 
ATOM   2174 C  C   . VAL B 2 79  ? -9.601  -2.107  -11.424 1.00 25.70  ? 77  VAL H C   1 
ATOM   2175 O  O   . VAL B 2 79  ? -8.566  -2.244  -10.753 1.00 24.17  ? 77  VAL H O   1 
ATOM   2176 C  CB  . VAL B 2 79  ? -11.496 -3.509  -10.466 1.00 21.59  ? 77  VAL H CB  1 
ATOM   2177 C  CG1 . VAL B 2 79  ? -12.049 -2.178  -9.972  1.00 22.81  ? 77  VAL H CG1 1 
ATOM   2178 C  CG2 . VAL B 2 79  ? -12.652 -4.417  -10.838 1.00 24.59  ? 77  VAL H CG2 1 
ATOM   2179 N  N   . THR B 2 80  ? -9.946  -0.939  -11.962 1.00 17.93  ? 78  THR H N   1 
ATOM   2180 C  CA  . THR B 2 80  ? -9.094  0.240   -11.805 1.00 18.47  ? 78  THR H CA  1 
ATOM   2181 C  C   . THR B 2 80  ? -9.749  1.322   -10.950 1.00 18.20  ? 78  THR H C   1 
ATOM   2182 O  O   . THR B 2 80  ? -10.972 1.356   -10.812 1.00 21.43  ? 78  THR H O   1 
ATOM   2183 C  CB  . THR B 2 80  ? -8.720  0.865   -13.173 1.00 26.07  ? 78  THR H CB  1 
ATOM   2184 O  OG1 . THR B 2 80  ? -9.923  1.205   -13.874 1.00 22.62  ? 78  THR H OG1 1 
ATOM   2185 C  CG2 . THR B 2 80  ? -7.872  -0.116  -14.029 1.00 20.39  ? 78  THR H CG2 1 
ATOM   2186 N  N   . LEU B 2 81  ? -8.916  2.183   -10.363 1.00 16.60  ? 79  LEU H N   1 
ATOM   2187 C  CA  . LEU B 2 81  ? -9.355  3.439   -9.754  1.00 18.26  ? 79  LEU H CA  1 
ATOM   2188 C  C   . LEU B 2 81  ? -8.622  4.577   -10.447 1.00 19.97  ? 79  LEU H C   1 
ATOM   2189 O  O   . LEU B 2 81  ? -7.401  4.705   -10.319 1.00 20.93  ? 79  LEU H O   1 
ATOM   2190 C  CB  . LEU B 2 81  ? -9.030  3.471   -8.256  1.00 18.18  ? 79  LEU H CB  1 
ATOM   2191 C  CG  . LEU B 2 81  ? -9.268  4.813   -7.543  1.00 19.47  ? 79  LEU H CG  1 
ATOM   2192 C  CD1 . LEU B 2 81  ? -10.768 5.181   -7.545  1.00 14.69  ? 79  LEU H CD1 1 
ATOM   2193 C  CD2 . LEU B 2 81  ? -8.721  4.807   -6.095  1.00 17.81  ? 79  LEU H CD2 1 
ATOM   2194 N  N   . GLN B 2 82  ? -9.347  5.401   -11.194 1.00 17.48  ? 80  GLN H N   1 
ATOM   2195 C  CA  . GLN B 2 82  ? -8.705  6.554   -11.838 1.00 21.35  ? 80  GLN H CA  1 
ATOM   2196 C  C   . GLN B 2 82  ? -8.921  7.819   -10.999 1.00 19.30  ? 80  GLN H C   1 
ATOM   2197 O  O   . GLN B 2 82  ? -10.053 8.148   -10.639 1.00 18.40  ? 80  GLN H O   1 
ATOM   2198 C  CB  . GLN B 2 82  ? -9.230  6.737   -13.266 1.00 20.66  ? 80  GLN H CB  1 
ATOM   2199 C  CG  . GLN B 2 82  ? -8.812  8.044   -13.923 1.00 21.96  ? 80  GLN H CG  1 
ATOM   2200 C  CD  . GLN B 2 82  ? -9.554  8.328   -15.225 1.00 27.46  ? 80  GLN H CD  1 
ATOM   2201 O  OE1 . GLN B 2 82  ? -10.314 9.294   -15.319 1.00 31.95  ? 80  GLN H OE1 1 
ATOM   2202 N  NE2 . GLN B 2 82  ? -9.323  7.496   -16.235 1.00 20.90  ? 80  GLN H NE2 1 
ATOM   2203 N  N   . MET B 2 83  ? -7.835  8.509   -10.663 1.00 13.27  ? 81  MET H N   1 
ATOM   2204 C  CA  . MET B 2 83  ? -7.915  9.703   -9.819  1.00 20.91  ? 81  MET H CA  1 
ATOM   2205 C  C   . MET B 2 83  ? -7.435  10.936  -10.582 1.00 17.90  ? 81  MET H C   1 
ATOM   2206 O  O   . MET B 2 83  ? -6.461  10.870  -11.324 1.00 19.35  ? 81  MET H O   1 
ATOM   2207 C  CB  . MET B 2 83  ? -7.087  9.540   -8.539  1.00 20.23  ? 81  MET H CB  1 
ATOM   2208 C  CG  . MET B 2 83  ? -7.550  8.400   -7.637  1.00 27.02  ? 81  MET H CG  1 
ATOM   2209 S  SD  . MET B 2 83  ? -6.673  8.344   -6.061  1.00 25.36  ? 81  MET H SD  1 
ATOM   2210 C  CE  . MET B 2 83  ? -5.080  7.749   -6.616  1.00 16.36  ? 81  MET H CE  1 
ATOM   2211 N  N   . THR B 2 84  ? -8.111  12.060  -10.386 1.00 19.45  ? 82  THR H N   1 
ATOM   2212 C  CA  . THR B 2 84  ? -7.715  13.307  -11.049 1.00 20.00  ? 82  THR H CA  1 
ATOM   2213 C  C   . THR B 2 84  ? -7.599  14.455  -10.041 1.00 26.46  ? 82  THR H C   1 
ATOM   2214 O  O   . THR B 2 84  ? -8.133  14.378  -8.926  1.00 21.92  ? 82  THR H O   1 
ATOM   2215 C  CB  . THR B 2 84  ? -8.730  13.719  -12.139 1.00 20.51  ? 82  THR H CB  1 
ATOM   2216 O  OG1 . THR B 2 84  ? -9.977  14.056  -11.521 1.00 24.09  ? 82  THR H OG1 1 
ATOM   2217 C  CG2 . THR B 2 84  ? -8.966  12.573  -13.130 1.00 21.83  ? 82  THR H CG2 1 
ATOM   2218 N  N   . SER B 2 85  A -6.894  15.518  -10.435 1.00 23.08  ? 82  SER H N   1 
ATOM   2219 C  CA  . SER B 2 85  A -6.741  16.708  -9.593  1.00 23.51  ? 82  SER H CA  1 
ATOM   2220 C  C   . SER B 2 85  A -6.240  16.405  -8.175  1.00 20.56  ? 82  SER H C   1 
ATOM   2221 O  O   . SER B 2 85  A -6.772  16.914  -7.181  1.00 20.85  ? 82  SER H O   1 
ATOM   2222 C  CB  . SER B 2 85  A -8.052  17.493  -9.542  1.00 23.65  ? 82  SER H CB  1 
ATOM   2223 O  OG  . SER B 2 85  A -8.460  17.866  -10.851 1.00 31.67  ? 82  SER H OG  1 
ATOM   2224 N  N   . LEU B 2 86  B -5.206  15.584  -8.079  1.00 24.23  ? 82  LEU H N   1 
ATOM   2225 C  CA  . LEU B 2 86  B -4.744  15.126  -6.772  1.00 20.62  ? 82  LEU H CA  1 
ATOM   2226 C  C   . LEU B 2 86  B -4.171  16.277  -5.928  1.00 27.26  ? 82  LEU H C   1 
ATOM   2227 O  O   . LEU B 2 86  B -3.511  17.176  -6.458  1.00 27.63  ? 82  LEU H O   1 
ATOM   2228 C  CB  . LEU B 2 86  B -3.712  14.021  -6.951  1.00 20.17  ? 82  LEU H CB  1 
ATOM   2229 C  CG  . LEU B 2 86  B -4.322  12.733  -7.510  1.00 23.76  ? 82  LEU H CG  1 
ATOM   2230 C  CD1 . LEU B 2 86  B -3.233  11.762  -7.935  1.00 21.76  ? 82  LEU H CD1 1 
ATOM   2231 C  CD2 . LEU B 2 86  B -5.244  12.096  -6.457  1.00 22.61  ? 82  LEU H CD2 1 
ATOM   2232 N  N   . THR B 2 87  ? -4.458  16.262  -4.627  1.00 23.20  ? 83  THR H N   1 
ATOM   2233 C  CA  . THR B 2 87  ? -3.786  17.144  -3.665  1.00 21.82  ? 83  THR H CA  1 
ATOM   2234 C  C   . THR B 2 87  ? -3.224  16.360  -2.475  1.00 31.32  ? 83  THR H C   1 
ATOM   2235 O  O   . THR B 2 87  ? -3.361  15.116  -2.396  1.00 21.83  ? 83  THR H O   1 
ATOM   2236 C  CB  . THR B 2 87  ? -4.700  18.277  -3.127  1.00 26.62  ? 83  THR H CB  1 
ATOM   2237 O  OG1 . THR B 2 87  ? -5.567  17.761  -2.109  1.00 26.51  ? 83  THR H OG1 1 
ATOM   2238 C  CG2 . THR B 2 87  ? -5.519  18.931  -4.252  1.00 23.52  ? 83  THR H CG2 1 
ATOM   2239 N  N   . ALA B 2 88  ? -2.583  17.083  -1.552  1.00 21.95  ? 84  ALA H N   1 
ATOM   2240 C  CA  . ALA B 2 88  ? -1.986  16.453  -0.376  1.00 27.52  ? 84  ALA H CA  1 
ATOM   2241 C  C   . ALA B 2 88  ? -3.037  15.720  0.450   1.00 27.70  ? 84  ALA H C   1 
ATOM   2242 O  O   . ALA B 2 88  ? -2.727  14.743  1.131   1.00 23.75  ? 84  ALA H O   1 
ATOM   2243 C  CB  . ALA B 2 88  ? -1.259  17.485  0.492   1.00 26.19  ? 84  ALA H CB  1 
ATOM   2244 N  N   . ALA B 2 89  ? -4.281  16.188  0.379   1.00 21.71  ? 85  ALA H N   1 
ATOM   2245 C  CA  . ALA B 2 89  ? -5.391  15.525  1.066   1.00 22.47  ? 85  ALA H CA  1 
ATOM   2246 C  C   . ALA B 2 89  ? -5.628  14.088  0.557   1.00 25.46  ? 85  ALA H C   1 
ATOM   2247 O  O   . ALA B 2 89  ? -6.294  13.291  1.225   1.00 19.68  ? 85  ALA H O   1 
ATOM   2248 C  CB  . ALA B 2 89  ? -6.667  16.358  0.938   1.00 24.92  ? 85  ALA H CB  1 
ATOM   2249 N  N   . ASP B 2 90  ? -5.082  13.764  -0.616  1.00 19.38  ? 86  ASP H N   1 
ATOM   2250 C  CA  . ASP B 2 90  ? -5.244  12.425  -1.206  1.00 19.95  ? 86  ASP H CA  1 
ATOM   2251 C  C   . ASP B 2 90  ? -4.080  11.461  -0.920  1.00 19.18  ? 86  ASP H C   1 
ATOM   2252 O  O   . ASP B 2 90  ? -4.097  10.292  -1.361  1.00 20.37  ? 86  ASP H O   1 
ATOM   2253 C  CB  . ASP B 2 90  ? -5.480  12.537  -2.715  1.00 16.30  ? 86  ASP H CB  1 
ATOM   2254 C  CG  . ASP B 2 90  ? -6.709  13.372  -3.052  1.00 21.83  ? 86  ASP H CG  1 
ATOM   2255 O  OD1 . ASP B 2 90  ? -6.590  14.339  -3.836  1.00 26.40  ? 86  ASP H OD1 1 
ATOM   2256 O  OD2 . ASP B 2 90  ? -7.799  13.069  -2.524  1.00 22.80  ? 86  ASP H OD2 1 
ATOM   2257 N  N   . THR B 2 91  ? -3.067  11.940  -0.201  1.00 17.58  ? 87  THR H N   1 
ATOM   2258 C  CA  . THR B 2 91  ? -1.935  11.089  0.173   1.00 19.17  ? 87  THR H CA  1 
ATOM   2259 C  C   . THR B 2 91  ? -2.433  9.978   1.093   1.00 19.13  ? 87  THR H C   1 
ATOM   2260 O  O   . THR B 2 91  ? -3.070  10.265  2.105   1.00 20.22  ? 87  THR H O   1 
ATOM   2261 C  CB  . THR B 2 91  ? -0.825  11.902  0.882   1.00 24.87  ? 87  THR H CB  1 
ATOM   2262 O  OG1 . THR B 2 91  ? -0.116  12.689  -0.085  1.00 23.78  ? 87  THR H OG1 1 
ATOM   2263 C  CG2 . THR B 2 91  ? 0.172   10.981  1.583   1.00 22.12  ? 87  THR H CG2 1 
ATOM   2264 N  N   . ALA B 2 92  ? -2.166  8.720   0.733   1.00 18.14  ? 88  ALA H N   1 
ATOM   2265 C  CA  . ALA B 2 92  ? -2.676  7.573   1.504   1.00 18.66  ? 88  ALA H CA  1 
ATOM   2266 C  C   . ALA B 2 92  ? -2.224  6.234   0.941   1.00 18.26  ? 88  ALA H C   1 
ATOM   2267 O  O   . ALA B 2 92  ? -1.712  6.165   -0.181  1.00 18.00  ? 88  ALA H O   1 
ATOM   2268 C  CB  . ALA B 2 92  ? -4.243  7.610   1.553   1.00 15.33  ? 88  ALA H CB  1 
ATOM   2269 N  N   . THR B 2 93  ? -2.447  5.168   1.716   1.00 17.86  ? 89  THR H N   1 
ATOM   2270 C  CA  . THR B 2 93  ? -2.458  3.803   1.180   1.00 14.36  ? 89  THR H CA  1 
ATOM   2271 C  C   . THR B 2 93  ? -3.873  3.501   0.638   1.00 17.99  ? 89  THR H C   1 
ATOM   2272 O  O   . THR B 2 93  ? -4.868  3.767   1.324   1.00 18.13  ? 89  THR H O   1 
ATOM   2273 C  CB  . THR B 2 93  ? -2.116  2.769   2.275   1.00 20.42  ? 89  THR H CB  1 
ATOM   2274 O  OG1 . THR B 2 93  ? -0.808  3.032   2.797   1.00 24.37  ? 89  THR H OG1 1 
ATOM   2275 C  CG2 . THR B 2 93  ? -2.171  1.313   1.716   1.00 17.84  ? 89  THR H CG2 1 
ATOM   2276 N  N   . TYR B 2 94  ? -3.942  2.944   -0.571  1.00 16.28  ? 90  TYR H N   1 
ATOM   2277 C  CA  . TYR B 2 94  ? -5.197  2.599   -1.244  1.00 15.52  ? 90  TYR H CA  1 
ATOM   2278 C  C   . TYR B 2 94  ? -5.380  1.086   -1.313  1.00 19.34  ? 90  TYR H C   1 
ATOM   2279 O  O   . TYR B 2 94  ? -4.543  0.389   -1.866  1.00 18.85  ? 90  TYR H O   1 
ATOM   2280 C  CB  . TYR B 2 94  ? -5.205  3.198   -2.654  1.00 12.86  ? 90  TYR H CB  1 
ATOM   2281 C  CG  . TYR B 2 94  ? -5.427  4.714   -2.643  1.00 17.31  ? 90  TYR H CG  1 
ATOM   2282 C  CD1 . TYR B 2 94  ? -6.639  5.264   -3.049  1.00 14.37  ? 90  TYR H CD1 1 
ATOM   2283 C  CD2 . TYR B 2 94  ? -4.436  5.579   -2.189  1.00 18.15  ? 90  TYR H CD2 1 
ATOM   2284 C  CE1 . TYR B 2 94  ? -6.862  6.636   -3.014  1.00 14.99  ? 90  TYR H CE1 1 
ATOM   2285 C  CE2 . TYR B 2 94  ? -4.653  6.961   -2.145  1.00 17.24  ? 90  TYR H CE2 1 
ATOM   2286 C  CZ  . TYR B 2 94  ? -5.864  7.479   -2.558  1.00 17.16  ? 90  TYR H CZ  1 
ATOM   2287 O  OH  . TYR B 2 94  ? -6.055  8.849   -2.517  1.00 19.26  ? 90  TYR H OH  1 
ATOM   2288 N  N   . PHE B 2 95  ? -6.470  0.584   -0.735  1.00 19.43  ? 91  PHE H N   1 
ATOM   2289 C  CA  . PHE B 2 95  ? -6.768  -0.854  -0.720  1.00 15.75  ? 91  PHE H CA  1 
ATOM   2290 C  C   . PHE B 2 95  ? -7.923  -1.149  -1.682  1.00 18.83  ? 91  PHE H C   1 
ATOM   2291 O  O   . PHE B 2 95  ? -8.822  -0.323  -1.838  1.00 15.62  ? 91  PHE H O   1 
ATOM   2292 C  CB  . PHE B 2 95  ? -7.256  -1.287  0.673   1.00 12.19  ? 91  PHE H CB  1 
ATOM   2293 C  CG  . PHE B 2 95  ? -6.241  -1.113  1.781   1.00 15.85  ? 91  PHE H CG  1 
ATOM   2294 C  CD1 . PHE B 2 95  ? -5.253  -2.061  1.987   1.00 19.18  ? 91  PHE H CD1 1 
ATOM   2295 C  CD2 . PHE B 2 95  ? -6.311  -0.030  2.630   1.00 18.59  ? 91  PHE H CD2 1 
ATOM   2296 C  CE1 . PHE B 2 95  ? -4.329  -1.927  3.028   1.00 17.50  ? 91  PHE H CE1 1 
ATOM   2297 C  CE2 . PHE B 2 95  ? -5.390  0.121   3.683   1.00 20.75  ? 91  PHE H CE2 1 
ATOM   2298 C  CZ  . PHE B 2 95  ? -4.398  -0.830  3.876   1.00 16.95  ? 91  PHE H CZ  1 
ATOM   2299 N  N   . CYS B 2 96  ? -7.936  -2.330  -2.296  1.00 15.02  ? 92  CYS H N   1 
ATOM   2300 C  CA  . CYS B 2 96  ? -9.179  -2.778  -2.927  1.00 16.55  ? 92  CYS H CA  1 
ATOM   2301 C  C   . CYS B 2 96  ? -9.670  -4.005  -2.175  1.00 15.92  ? 92  CYS H C   1 
ATOM   2302 O  O   . CYS B 2 96  ? -8.884  -4.679  -1.532  1.00 16.67  ? 92  CYS H O   1 
ATOM   2303 C  CB  . CYS B 2 96  ? -9.019  -3.055  -4.421  1.00 19.55  ? 92  CYS H CB  1 
ATOM   2304 S  SG  . CYS B 2 96  ? -8.066  -4.541  -4.854  1.00 35.53  ? 92  CYS H SG  1 
ATOM   2305 N  N   . ALA B 2 97  ? -10.975 -4.261  -2.216  1.00 15.90  ? 93  ALA H N   1 
ATOM   2306 C  CA  . ALA B 2 97  ? -11.538 -5.383  -1.479  1.00 20.52  ? 93  ALA H CA  1 
ATOM   2307 C  C   . ALA B 2 97  ? -12.700 -6.015  -2.231  1.00 19.92  ? 93  ALA H C   1 
ATOM   2308 O  O   . ALA B 2 97  ? -13.409 -5.332  -2.963  1.00 19.78  ? 93  ALA H O   1 
ATOM   2309 C  CB  . ALA B 2 97  ? -11.999 -4.936  -0.094  1.00 19.82  ? 93  ALA H CB  1 
ATOM   2310 N  N   . ARG B 2 98  ? -12.897 -7.315  -2.025  1.00 15.54  ? 94  ARG H N   1 
ATOM   2311 C  CA  . ARG B 2 98  ? -14.044 -8.025  -2.568  1.00 18.04  ? 94  ARG H CA  1 
ATOM   2312 C  C   . ARG B 2 98  ? -15.086 -8.262  -1.462  1.00 17.01  ? 94  ARG H C   1 
ATOM   2313 O  O   . ARG B 2 98  ? -14.825 -9.020  -0.519  1.00 20.12  ? 94  ARG H O   1 
ATOM   2314 C  CB  . ARG B 2 98  ? -13.581 -9.373  -3.161  1.00 15.66  ? 94  ARG H CB  1 
ATOM   2315 C  CG  . ARG B 2 98  ? -14.695 -10.186 -3.828  1.00 19.44  ? 94  ARG H CG  1 
ATOM   2316 C  CD  . ARG B 2 98  ? -14.170 -11.566 -4.282  1.00 22.37  ? 94  ARG H CD  1 
ATOM   2317 N  NE  . ARG B 2 98  ? -14.209 -12.550 -3.190  1.00 22.07  ? 94  ARG H NE  1 
ATOM   2318 C  CZ  . ARG B 2 98  ? -13.802 -13.816 -3.299  1.00 35.51  ? 94  ARG H CZ  1 
ATOM   2319 N  NH1 . ARG B 2 98  ? -13.891 -14.630 -2.256  1.00 28.58  ? 94  ARG H NH1 1 
ATOM   2320 N  NH2 . ARG B 2 98  ? -13.299 -14.270 -4.443  1.00 28.98  ? 94  ARG H NH2 1 
ATOM   2321 N  N   . ASN B 2 99  ? -16.260 -7.637  -1.581  1.00 17.24  ? 95  ASN H N   1 
ATOM   2322 C  CA  . ASN B 2 99  ? -17.297 -7.721  -0.541  1.00 20.05  ? 95  ASN H CA  1 
ATOM   2323 C  C   . ASN B 2 99  ? -16.754 -7.369  0.863   1.00 23.90  ? 95  ASN H C   1 
ATOM   2324 O  O   . ASN B 2 99  ? -17.230 -7.918  1.879   1.00 18.52  ? 95  ASN H O   1 
ATOM   2325 C  CB  . ASN B 2 99  ? -17.928 -9.131  -0.491  1.00 18.06  ? 95  ASN H CB  1 
ATOM   2326 C  CG  . ASN B 2 99  ? -18.684 -9.504  -1.770  1.00 27.33  ? 95  ASN H CG  1 
ATOM   2327 O  OD1 . ASN B 2 99  ? -18.892 -8.677  -2.644  1.00 25.21  ? 95  ASN H OD1 1 
ATOM   2328 N  ND2 . ASN B 2 99  ? -19.102 -10.763 -1.867  1.00 26.38  ? 95  ASN H ND2 1 
ATOM   2329 N  N   . PHE B 2 100 ? -15.734 -6.503  0.911   1.00 16.67  ? 96  PHE H N   1 
ATOM   2330 C  CA  . PHE B 2 100 ? -15.101 -6.098  2.179   1.00 19.10  ? 96  PHE H CA  1 
ATOM   2331 C  C   . PHE B 2 100 ? -14.584 -7.285  3.001   1.00 22.10  ? 96  PHE H C   1 
ATOM   2332 O  O   . PHE B 2 100 ? -14.409 -7.182  4.214   1.00 19.98  ? 96  PHE H O   1 
ATOM   2333 C  CB  . PHE B 2 100 ? -16.056 -5.223  3.015   1.00 18.37  ? 96  PHE H CB  1 
ATOM   2334 C  CG  . PHE B 2 100 ? -16.368 -3.888  2.371   1.00 15.44  ? 96  PHE H CG  1 
ATOM   2335 C  CD1 . PHE B 2 100 ? -17.511 -3.727  1.591   1.00 17.01  ? 96  PHE H CD1 1 
ATOM   2336 C  CD2 . PHE B 2 100 ? -15.501 -2.823  2.509   1.00 18.53  ? 96  PHE H CD2 1 
ATOM   2337 C  CE1 . PHE B 2 100 ? -17.784 -2.526  0.978   1.00 15.87  ? 96  PHE H CE1 1 
ATOM   2338 C  CE2 . PHE B 2 100 ? -15.765 -1.598  1.892   1.00 15.89  ? 96  PHE H CE2 1 
ATOM   2339 C  CZ  . PHE B 2 100 ? -16.909 -1.452  1.126   1.00 16.98  ? 96  PHE H CZ  1 
ATOM   2340 N  N   . ASP B 2 101 ? -14.300 -8.389  2.313   1.00 19.25  ? 101 ASP H N   1 
ATOM   2341 C  CA  . ASP B 2 101 ? -13.985 -9.672  2.936   1.00 15.23  ? 101 ASP H CA  1 
ATOM   2342 C  C   . ASP B 2 101 ? -12.555 -10.104 2.539   1.00 23.06  ? 101 ASP H C   1 
ATOM   2343 O  O   . ASP B 2 101 ? -11.704 -10.340 3.390   1.00 21.19  ? 101 ASP H O   1 
ATOM   2344 C  CB  . ASP B 2 101 ? -15.062 -10.668 2.490   1.00 23.11  ? 101 ASP H CB  1 
ATOM   2345 C  CG  . ASP B 2 101 ? -14.804 -12.087 2.936   1.00 35.59  ? 101 ASP H CG  1 
ATOM   2346 O  OD1 . ASP B 2 101 ? -14.098 -12.313 3.940   1.00 27.47  ? 101 ASP H OD1 1 
ATOM   2347 O  OD2 . ASP B 2 101 ? -15.344 -12.990 2.264   1.00 48.00  ? 101 ASP H OD2 1 
ATOM   2348 N  N   . LEU B 2 102 ? -12.293 -10.174 1.242   1.00 23.62  ? 102 LEU H N   1 
ATOM   2349 C  CA  . LEU B 2 102 ? -10.943 -10.387 0.723   1.00 21.90  ? 102 LEU H CA  1 
ATOM   2350 C  C   . LEU B 2 102 ? -10.295 -9.015  0.481   1.00 22.76  ? 102 LEU H C   1 
ATOM   2351 O  O   . LEU B 2 102 ? -10.884 -8.189  -0.209  1.00 18.15  ? 102 LEU H O   1 
ATOM   2352 C  CB  . LEU B 2 102 ? -11.044 -11.138 -0.614  1.00 22.26  ? 102 LEU H CB  1 
ATOM   2353 C  CG  . LEU B 2 102 ? -10.106 -12.284 -0.987  1.00 33.13  ? 102 LEU H CG  1 
ATOM   2354 C  CD1 . LEU B 2 102 ? -10.005 -12.435 -2.512  1.00 28.59  ? 102 LEU H CD1 1 
ATOM   2355 C  CD2 . LEU B 2 102 ? -8.739  -12.160 -0.350  1.00 32.62  ? 102 LEU H CD2 1 
ATOM   2356 N  N   . TRP B 2 103 ? -9.092  -8.781  1.017   1.00 18.64  ? 103 TRP H N   1 
ATOM   2357 C  CA  . TRP B 2 103 ? -8.380  -7.505  0.849   1.00 20.00  ? 103 TRP H CA  1 
ATOM   2358 C  C   . TRP B 2 103 ? -6.970  -7.664  0.244   1.00 23.70  ? 103 TRP H C   1 
ATOM   2359 O  O   . TRP B 2 103 ? -6.280  -8.648  0.500   1.00 19.50  ? 103 TRP H O   1 
ATOM   2360 C  CB  . TRP B 2 103 ? -8.230  -6.777  2.198   1.00 20.34  ? 103 TRP H CB  1 
ATOM   2361 C  CG  . TRP B 2 103 ? -9.516  -6.328  2.865   1.00 19.36  ? 103 TRP H CG  1 
ATOM   2362 C  CD1 . TRP B 2 103 ? -10.440 -7.124  3.474   1.00 21.46  ? 103 TRP H CD1 1 
ATOM   2363 C  CD2 . TRP B 2 103 ? -9.980  -4.973  3.041   1.00 17.21  ? 103 TRP H CD2 1 
ATOM   2364 N  NE1 . TRP B 2 103 ? -11.460 -6.360  3.995   1.00 14.58  ? 103 TRP H NE1 1 
ATOM   2365 C  CE2 . TRP B 2 103 ? -11.204 -5.039  3.739   1.00 15.98  ? 103 TRP H CE2 1 
ATOM   2366 C  CE3 . TRP B 2 103 ? -9.489  -3.723  2.661   1.00 17.43  ? 103 TRP H CE3 1 
ATOM   2367 C  CZ2 . TRP B 2 103 ? -11.935 -3.900  4.075   1.00 17.96  ? 103 TRP H CZ2 1 
ATOM   2368 C  CZ3 . TRP B 2 103 ? -10.220 -2.594  2.985   1.00 20.48  ? 103 TRP H CZ3 1 
ATOM   2369 C  CH2 . TRP B 2 103 ? -11.434 -2.690  3.689   1.00 15.90  ? 103 TRP H CH2 1 
ATOM   2370 N  N   . GLY B 2 104 ? -6.547  -6.675  -0.546  1.00 18.93  ? 104 GLY H N   1 
ATOM   2371 C  CA  . GLY B 2 104 ? -5.167  -6.579  -0.991  1.00 18.00  ? 104 GLY H CA  1 
ATOM   2372 C  C   . GLY B 2 104 ? -4.273  -5.966  0.080   1.00 17.67  ? 104 GLY H C   1 
ATOM   2373 O  O   . GLY B 2 104 ? -4.760  -5.406  1.070   1.00 18.05  ? 104 GLY H O   1 
ATOM   2374 N  N   . PRO B 2 105 ? -2.954  -6.075  -0.098  1.00 18.92  ? 105 PRO H N   1 
ATOM   2375 C  CA  . PRO B 2 105 ? -2.026  -5.504  0.884   1.00 24.46  ? 105 PRO H CA  1 
ATOM   2376 C  C   . PRO B 2 105 ? -1.941  -3.982  0.807   1.00 26.05  ? 105 PRO H C   1 
ATOM   2377 O  O   . PRO B 2 105 ? -1.378  -3.374  1.720   1.00 21.38  ? 105 PRO H O   1 
ATOM   2378 C  CB  . PRO B 2 105 ? -0.677  -6.132  0.500   1.00 23.51  ? 105 PRO H CB  1 
ATOM   2379 C  CG  . PRO B 2 105 ? -0.804  -6.406  -0.949  1.00 29.46  ? 105 PRO H CG  1 
ATOM   2380 C  CD  . PRO B 2 105 ? -2.252  -6.751  -1.203  1.00 24.01  ? 105 PRO H CD  1 
ATOM   2381 N  N   . GLY B 2 106 ? -2.479  -3.376  -0.252  1.00 18.86  ? 106 GLY H N   1 
ATOM   2382 C  CA  . GLY B 2 106 ? -2.476  -1.919  -0.363  1.00 21.73  ? 106 GLY H CA  1 
ATOM   2383 C  C   . GLY B 2 106 ? -1.356  -1.361  -1.226  1.00 25.70  ? 106 GLY H C   1 
ATOM   2384 O  O   . GLY B 2 106 ? -0.313  -1.994  -1.376  1.00 24.68  ? 106 GLY H O   1 
ATOM   2385 N  N   . THR B 2 107 ? -1.575  -0.187  -1.812  1.00 21.97  ? 107 THR H N   1 
ATOM   2386 C  CA  . THR B 2 107 ? -0.529  0.479   -2.600  1.00 23.36  ? 107 THR H CA  1 
ATOM   2387 C  C   . THR B 2 107 ? -0.495  1.956   -2.197  1.00 25.22  ? 107 THR H C   1 
ATOM   2388 O  O   . THR B 2 107 ? -1.545  2.581   -1.991  1.00 20.71  ? 107 THR H O   1 
ATOM   2389 C  CB  . THR B 2 107 ? -0.714  0.269   -4.135  1.00 24.70  ? 107 THR H CB  1 
ATOM   2390 O  OG1 . THR B 2 107 ? 0.425   0.767   -4.856  1.00 21.55  ? 107 THR H OG1 1 
ATOM   2391 C  CG2 . THR B 2 107 ? -1.975  0.951   -4.650  1.00 21.02  ? 107 THR H CG2 1 
ATOM   2392 N  N   . LEU B 2 108 ? 0.710   2.498   -2.052  1.00 18.31  ? 108 LEU H N   1 
ATOM   2393 C  CA  . LEU B 2 108 ? 0.897   3.821   -1.458  1.00 19.30  ? 108 LEU H CA  1 
ATOM   2394 C  C   . LEU B 2 108 ? 0.923   4.957   -2.487  1.00 25.18  ? 108 LEU H C   1 
ATOM   2395 O  O   . LEU B 2 108 ? 1.656   4.900   -3.467  1.00 25.25  ? 108 LEU H O   1 
ATOM   2396 C  CB  . LEU B 2 108 ? 2.184   3.845   -0.613  1.00 23.11  ? 108 LEU H CB  1 
ATOM   2397 C  CG  . LEU B 2 108 ? 2.514   5.165   0.088   1.00 27.41  ? 108 LEU H CG  1 
ATOM   2398 C  CD1 . LEU B 2 108 ? 1.481   5.505   1.150   1.00 24.71  ? 108 LEU H CD1 1 
ATOM   2399 C  CD2 . LEU B 2 108 ? 3.928   5.136   0.682   1.00 36.33  ? 108 LEU H CD2 1 
ATOM   2400 N  N   . VAL B 2 109 ? 0.134   6.000   -2.246  1.00 25.36  ? 109 VAL H N   1 
ATOM   2401 C  CA  . VAL B 2 109 ? 0.155   7.182   -3.096  1.00 21.75  ? 109 VAL H CA  1 
ATOM   2402 C  C   . VAL B 2 109 ? 0.610   8.398   -2.289  1.00 24.16  ? 109 VAL H C   1 
ATOM   2403 O  O   . VAL B 2 109 ? 0.067   8.677   -1.222  1.00 21.06  ? 109 VAL H O   1 
ATOM   2404 C  CB  . VAL B 2 109 ? -1.245  7.482   -3.707  1.00 20.68  ? 109 VAL H CB  1 
ATOM   2405 C  CG1 . VAL B 2 109 ? -1.237  8.823   -4.431  1.00 21.47  ? 109 VAL H CG1 1 
ATOM   2406 C  CG2 . VAL B 2 109 ? -1.674  6.344   -4.664  1.00 19.82  ? 109 VAL H CG2 1 
ATOM   2407 N  N   . ILE B 2 110 ? 1.610   9.115   -2.795  1.00 24.01  ? 110 ILE H N   1 
ATOM   2408 C  CA  . ILE B 2 110 ? 2.109   10.313  -2.122  1.00 21.32  ? 110 ILE H CA  1 
ATOM   2409 C  C   . ILE B 2 110 ? 1.977   11.510  -3.065  1.00 24.01  ? 110 ILE H C   1 
ATOM   2410 O  O   . ILE B 2 110 ? 2.557   11.518  -4.149  1.00 25.04  ? 110 ILE H O   1 
ATOM   2411 C  CB  . ILE B 2 110 ? 3.607   10.194  -1.751  1.00 28.19  ? 110 ILE H CB  1 
ATOM   2412 C  CG1 . ILE B 2 110 ? 3.915   8.854   -1.084  1.00 29.32  ? 110 ILE H CG1 1 
ATOM   2413 C  CG2 . ILE B 2 110 ? 4.013   11.337  -0.837  1.00 20.20  ? 110 ILE H CG2 1 
ATOM   2414 C  CD1 . ILE B 2 110 ? 3.370   8.755   0.325   1.00 31.37  ? 110 ILE H CD1 1 
ATOM   2415 N  N   . VAL B 2 111 ? 1.225   12.520  -2.663  1.00 26.84  ? 111 VAL H N   1 
ATOM   2416 C  CA  . VAL B 2 111 ? 1.082   13.707  -3.505  1.00 26.35  ? 111 VAL H CA  1 
ATOM   2417 C  C   . VAL B 2 111 ? 1.849   14.864  -2.889  1.00 26.45  ? 111 VAL H C   1 
ATOM   2418 O  O   . VAL B 2 111 ? 1.458   15.392  -1.846  1.00 26.82  ? 111 VAL H O   1 
ATOM   2419 C  CB  . VAL B 2 111 ? -0.389  14.112  -3.705  1.00 23.12  ? 111 VAL H CB  1 
ATOM   2420 C  CG1 . VAL B 2 111 ? -0.480  15.324  -4.625  1.00 22.37  ? 111 VAL H CG1 1 
ATOM   2421 C  CG2 . VAL B 2 111 ? -1.193  12.934  -4.273  1.00 21.52  ? 111 VAL H CG2 1 
ATOM   2422 N  N   . SER B 2 112 ? 2.932   15.267  -3.554  1.00 28.44  ? 112 SER H N   1 
ATOM   2423 C  CA  . SER B 2 112 ? 3.857   16.254  -3.004  1.00 29.23  ? 112 SER H CA  1 
ATOM   2424 C  C   . SER B 2 112 ? 4.768   16.829  -4.079  1.00 29.82  ? 112 SER H C   1 
ATOM   2425 O  O   . SER B 2 112 ? 5.094   16.151  -5.052  1.00 32.00  ? 112 SER H O   1 
ATOM   2426 C  CB  . SER B 2 112 ? 4.716   15.598  -1.915  1.00 36.04  ? 112 SER H CB  1 
ATOM   2427 O  OG  . SER B 2 112 ? 5.829   16.403  -1.561  1.00 31.93  ? 112 SER H OG  1 
ATOM   2428 N  N   . SER B 2 113 ? 5.196   18.070  -3.891  1.00 26.69  ? 113 SER H N   1 
ATOM   2429 C  CA  . SER B 2 113 ? 6.129   18.691  -4.826  1.00 41.43  ? 113 SER H CA  1 
ATOM   2430 C  C   . SER B 2 113 ? 7.581   18.505  -4.373  1.00 39.44  ? 113 SER H C   1 
ATOM   2431 O  O   . SER B 2 113 ? 8.510   18.939  -5.048  1.00 45.91  ? 113 SER H O   1 
ATOM   2432 C  CB  . SER B 2 113 ? 5.797   20.173  -5.012  1.00 35.75  ? 113 SER H CB  1 
ATOM   2433 O  OG  . SER B 2 113 ? 5.645   20.801  -3.755  1.00 38.72  ? 113 SER H OG  1 
ATOM   2434 N  N   . GLY B 2 114 ? 7.774   17.847  -3.233  1.00 41.19  ? 114 GLY H N   1 
ATOM   2435 C  CA  . GLY B 2 114 ? 9.112   17.578  -2.720  1.00 40.00  ? 114 GLY H CA  1 
ATOM   2436 C  C   . GLY B 2 114 ? 9.936   16.717  -3.658  1.00 36.48  ? 114 GLY H C   1 
ATOM   2437 O  O   . GLY B 2 114 ? 9.385   15.855  -4.342  1.00 42.50  ? 114 GLY H O   1 
ATOM   2438 N  N   . GLN B 2 115 ? 11.248  16.935  -3.716  1.00 39.75  ? 115 GLN H N   1 
ATOM   2439 C  CA  . GLN B 2 115 ? 12.052  16.118  -4.617  1.00 34.60  ? 115 GLN H CA  1 
ATOM   2440 C  C   . GLN B 2 115 ? 12.639  14.925  -3.872  1.00 31.10  ? 115 GLN H C   1 
ATOM   2441 O  O   . GLN B 2 115 ? 13.044  15.051  -2.722  1.00 31.17  ? 115 GLN H O   1 
ATOM   2442 C  CB  . GLN B 2 115 ? 13.124  16.951  -5.323  1.00 45.58  ? 115 GLN H CB  1 
ATOM   2443 C  CG  . GLN B 2 115 ? 12.548  18.082  -6.201  1.00 51.09  ? 115 GLN H CG  1 
ATOM   2444 C  CD  . GLN B 2 115 ? 11.708  17.584  -7.380  1.00 52.29  ? 115 GLN H CD  1 
ATOM   2445 O  OE1 . GLN B 2 115 ? 12.112  16.678  -8.113  1.00 49.65  ? 115 GLN H OE1 1 
ATOM   2446 N  NE2 . GLN B 2 115 ? 10.530  18.181  -7.561  1.00 53.50  ? 115 GLN H NE2 1 
ATOM   2447 N  N   . PRO B 2 116 ? 12.657  13.752  -4.523  1.00 29.32  ? 116 PRO H N   1 
ATOM   2448 C  CA  . PRO B 2 116 ? 13.105  12.529  -3.856  1.00 28.08  ? 116 PRO H CA  1 
ATOM   2449 C  C   . PRO B 2 116 ? 14.562  12.640  -3.438  1.00 34.52  ? 116 PRO H C   1 
ATOM   2450 O  O   . PRO B 2 116 ? 15.336  13.333  -4.106  1.00 29.83  ? 116 PRO H O   1 
ATOM   2451 C  CB  . PRO B 2 116 ? 12.967  11.463  -4.945  1.00 32.97  ? 116 PRO H CB  1 
ATOM   2452 C  CG  . PRO B 2 116 ? 12.047  12.049  -5.965  1.00 35.17  ? 116 PRO H CG  1 
ATOM   2453 C  CD  . PRO B 2 116 ? 12.289  13.515  -5.927  1.00 31.81  ? 116 PRO H CD  1 
ATOM   2454 N  N   . LYS B 2 117 ? 14.918  11.977  -2.342  1.00 25.99  ? 117 LYS H N   1 
ATOM   2455 C  CA  . LYS B 2 117 ? 16.303  11.921  -1.878  1.00 25.39  ? 117 LYS H CA  1 
ATOM   2456 C  C   . LYS B 2 117 ? 16.623  10.522  -1.343  1.00 28.36  ? 117 LYS H C   1 
ATOM   2457 O  O   . LYS B 2 117 ? 15.912  9.995   -0.490  1.00 25.96  ? 117 LYS H O   1 
ATOM   2458 C  CB  . LYS B 2 117 ? 16.543  12.988  -0.807  1.00 30.68  ? 117 LYS H CB  1 
ATOM   2459 C  CG  . LYS B 2 117 ? 17.960  13.035  -0.278  1.00 41.13  ? 117 LYS H CG  1 
ATOM   2460 C  CD  . LYS B 2 117 ? 18.134  14.207  0.673   1.00 46.06  ? 117 LYS H CD  1 
ATOM   2461 C  CE  . LYS B 2 117 ? 19.540  14.237  1.270   1.00 47.25  ? 117 LYS H CE  1 
ATOM   2462 N  NZ  . LYS B 2 117 ? 19.832  13.077  2.164   1.00 43.02  ? 117 LYS H NZ  1 
ATOM   2463 N  N   . ALA B 2 118 ? 17.682  9.914   -1.868  1.00 21.74  ? 118 ALA H N   1 
ATOM   2464 C  CA  . ALA B 2 118 ? 18.057  8.554   -1.502  1.00 25.88  ? 118 ALA H CA  1 
ATOM   2465 C  C   . ALA B 2 118 ? 18.664  8.516   -0.100  1.00 24.97  ? 118 ALA H C   1 
ATOM   2466 O  O   . ALA B 2 118 ? 19.297  9.479   0.330   1.00 25.17  ? 118 ALA H O   1 
ATOM   2467 C  CB  . ALA B 2 118 ? 19.044  7.993   -2.527  1.00 30.06  ? 118 ALA H CB  1 
ATOM   2468 N  N   . PRO B 2 119 ? 18.478  7.397   0.616   1.00 22.91  ? 119 PRO H N   1 
ATOM   2469 C  CA  . PRO B 2 119 ? 18.962  7.294   1.997   1.00 23.05  ? 119 PRO H CA  1 
ATOM   2470 C  C   . PRO B 2 119 ? 20.477  7.122   2.083   1.00 20.71  ? 119 PRO H C   1 
ATOM   2471 O  O   . PRO B 2 119 ? 21.068  6.552   1.184   1.00 23.99  ? 119 PRO H O   1 
ATOM   2472 C  CB  . PRO B 2 119 ? 18.313  6.006   2.485   1.00 22.69  ? 119 PRO H CB  1 
ATOM   2473 C  CG  . PRO B 2 119 ? 18.168  5.188   1.266   1.00 26.02  ? 119 PRO H CG  1 
ATOM   2474 C  CD  . PRO B 2 119 ? 17.804  6.164   0.184   1.00 23.53  ? 119 PRO H CD  1 
ATOM   2475 N  N   . SER B 2 120 ? 21.077  7.604   3.166   1.00 23.75  ? 120 SER H N   1 
ATOM   2476 C  CA  . SER B 2 120 ? 22.414  7.176   3.551   1.00 28.02  ? 120 SER H CA  1 
ATOM   2477 C  C   . SER B 2 120 ? 22.265  6.018   4.541   1.00 30.59  ? 120 SER H C   1 
ATOM   2478 O  O   . SER B 2 120 ? 21.405  6.053   5.433   1.00 29.51  ? 120 SER H O   1 
ATOM   2479 C  CB  . SER B 2 120 ? 23.189  8.341   4.180   1.00 30.38  ? 120 SER H CB  1 
ATOM   2480 O  OG  . SER B 2 120 ? 23.355  9.394   3.237   1.00 32.87  ? 120 SER H OG  1 
ATOM   2481 N  N   . VAL B 2 121 ? 23.086  4.988   4.376   1.00 25.63  ? 121 VAL H N   1 
ATOM   2482 C  CA  . VAL B 2 121 ? 23.038  3.827   5.259   1.00 23.43  ? 121 VAL H CA  1 
ATOM   2483 C  C   . VAL B 2 121 ? 24.346  3.681   6.058   1.00 29.03  ? 121 VAL H C   1 
ATOM   2484 O  O   . VAL B 2 121 ? 25.427  3.631   5.473   1.00 24.80  ? 121 VAL H O   1 
ATOM   2485 C  CB  . VAL B 2 121 ? 22.787  2.553   4.449   1.00 22.19  ? 121 VAL H CB  1 
ATOM   2486 C  CG1 . VAL B 2 121 ? 22.670  1.351   5.385   1.00 27.87  ? 121 VAL H CG1 1 
ATOM   2487 C  CG2 . VAL B 2 121 ? 21.507  2.700   3.591   1.00 21.39  ? 121 VAL H CG2 1 
ATOM   2488 N  N   . PHE B 2 122 ? 24.243  3.605   7.384   1.00 23.09  ? 122 PHE H N   1 
ATOM   2489 C  CA  . PHE B 2 122 ? 25.416  3.436   8.246   1.00 24.19  ? 122 PHE H CA  1 
ATOM   2490 C  C   . PHE B 2 122 ? 25.253  2.211   9.131   1.00 27.89  ? 122 PHE H C   1 
ATOM   2491 O  O   . PHE B 2 122 ? 24.145  1.931   9.575   1.00 28.00  ? 122 PHE H O   1 
ATOM   2492 C  CB  . PHE B 2 122 ? 25.586  4.649   9.140   1.00 23.41  ? 122 PHE H CB  1 
ATOM   2493 C  CG  . PHE B 2 122 ? 25.742  5.949   8.384   1.00 29.37  ? 122 PHE H CG  1 
ATOM   2494 C  CD1 . PHE B 2 122 ? 26.965  6.300   7.826   1.00 27.15  ? 122 PHE H CD1 1 
ATOM   2495 C  CD2 . PHE B 2 122 ? 24.669  6.811   8.236   1.00 22.17  ? 122 PHE H CD2 1 
ATOM   2496 C  CE1 . PHE B 2 122 ? 27.116  7.482   7.134   1.00 27.22  ? 122 PHE H CE1 1 
ATOM   2497 C  CE2 . PHE B 2 122 ? 24.811  8.010   7.549   1.00 36.38  ? 122 PHE H CE2 1 
ATOM   2498 C  CZ  . PHE B 2 122 ? 26.041  8.346   6.993   1.00 32.02  ? 122 PHE H CZ  1 
ATOM   2499 N  N   . PRO B 2 123 ? 26.353  1.487   9.410   1.00 28.79  ? 123 PRO H N   1 
ATOM   2500 C  CA  . PRO B 2 123 ? 26.254  0.285   10.250  1.00 29.82  ? 123 PRO H CA  1 
ATOM   2501 C  C   . PRO B 2 123 ? 26.114  0.625   11.738  1.00 27.39  ? 123 PRO H C   1 
ATOM   2502 O  O   . PRO B 2 123 ? 26.565  1.687   12.179  1.00 26.44  ? 123 PRO H O   1 
ATOM   2503 C  CB  . PRO B 2 123 ? 27.591  -0.426  9.995   1.00 29.20  ? 123 PRO H CB  1 
ATOM   2504 C  CG  . PRO B 2 123 ? 28.528  0.675   9.665   1.00 33.92  ? 123 PRO H CG  1 
ATOM   2505 C  CD  . PRO B 2 123 ? 27.720  1.680   8.889   1.00 30.76  ? 123 PRO H CD  1 
ATOM   2506 N  N   . LEU B 2 124 ? 25.484  -0.276  12.488  1.00 27.96  ? 124 LEU H N   1 
ATOM   2507 C  CA  . LEU B 2 124 ? 25.351  -0.151  13.938  1.00 26.84  ? 124 LEU H CA  1 
ATOM   2508 C  C   . LEU B 2 124 ? 25.990  -1.364  14.589  1.00 28.31  ? 124 LEU H C   1 
ATOM   2509 O  O   . LEU B 2 124 ? 25.618  -2.510  14.294  1.00 27.52  ? 124 LEU H O   1 
ATOM   2510 C  CB  . LEU B 2 124 ? 23.870  -0.080  14.355  1.00 20.53  ? 124 LEU H CB  1 
ATOM   2511 C  CG  . LEU B 2 124 ? 23.011  1.061   13.774  1.00 26.95  ? 124 LEU H CG  1 
ATOM   2512 C  CD1 . LEU B 2 124 ? 21.530  0.886   14.139  1.00 20.85  ? 124 LEU H CD1 1 
ATOM   2513 C  CD2 . LEU B 2 124 ? 23.505  2.422   14.244  1.00 21.64  ? 124 LEU H CD2 1 
ATOM   2514 N  N   . ALA B 2 125 ? 26.943  -1.114  15.478  1.00 26.86  ? 125 ALA H N   1 
ATOM   2515 C  CA  . ALA B 2 125 ? 27.626  -2.197  16.178  1.00 31.73  ? 125 ALA H CA  1 
ATOM   2516 C  C   . ALA B 2 125 ? 28.087  -1.706  17.546  1.00 30.78  ? 125 ALA H C   1 
ATOM   2517 O  O   . ALA B 2 125 ? 28.385  -0.528  17.706  1.00 29.53  ? 125 ALA H O   1 
ATOM   2518 C  CB  . ALA B 2 125 ? 28.800  -2.698  15.355  1.00 32.36  ? 125 ALA H CB  1 
ATOM   2519 N  N   . PRO B 2 126 ? 28.138  -2.608  18.543  1.00 38.07  ? 126 PRO H N   1 
ATOM   2520 C  CA  . PRO B 2 126 ? 28.581  -2.229  19.889  1.00 41.16  ? 126 PRO H CA  1 
ATOM   2521 C  C   . PRO B 2 126 ? 29.967  -1.592  19.876  1.00 44.66  ? 126 PRO H C   1 
ATOM   2522 O  O   . PRO B 2 126 ? 30.766  -1.877  18.981  1.00 44.38  ? 126 PRO H O   1 
ATOM   2523 C  CB  . PRO B 2 126 ? 28.617  -3.568  20.640  1.00 45.06  ? 126 PRO H CB  1 
ATOM   2524 C  CG  . PRO B 2 126 ? 28.655  -4.624  19.566  1.00 47.93  ? 126 PRO H CG  1 
ATOM   2525 C  CD  . PRO B 2 126 ? 27.838  -4.049  18.452  1.00 38.34  ? 126 PRO H CD  1 
ATOM   2526 N  N   . CYS B 2 127 ? 30.238  -0.730  20.851  1.00 44.96  ? 127 CYS H N   1 
ATOM   2527 C  CA  . CYS B 2 127 ? 31.515  -0.026  20.908  1.00 47.58  ? 127 CYS H CA  1 
ATOM   2528 C  C   . CYS B 2 127 ? 32.690  -0.994  21.014  1.00 57.86  ? 127 CYS H C   1 
ATOM   2529 O  O   . CYS B 2 127 ? 32.610  -2.026  21.692  1.00 52.58  ? 127 CYS H O   1 
ATOM   2530 C  CB  . CYS B 2 127 ? 31.545  0.977   22.068  1.00 43.73  ? 127 CYS H CB  1 
ATOM   2531 S  SG  . CYS B 2 127 ? 33.014  2.096   22.093  1.00 45.17  ? 127 CYS H SG  1 
ATOM   2532 N  N   . CYS B 2 128 ? 33.765  -0.650  20.309  1.00 67.64  ? 128 CYS H N   1 
ATOM   2533 C  CA  . CYS B 2 128 ? 35.021  -1.381  20.381  1.00 75.58  ? 128 CYS H CA  1 
ATOM   2534 C  C   . CYS B 2 128 ? 35.488  -1.408  21.836  1.00 71.46  ? 128 CYS H C   1 
ATOM   2535 O  O   . CYS B 2 128 ? 36.038  -0.430  22.348  1.00 75.76  ? 128 CYS H O   1 
ATOM   2536 C  CB  . CYS B 2 128 ? 36.069  -0.721  19.473  1.00 64.30  ? 128 CYS H CB  1 
ATOM   2537 S  SG  . CYS B 2 128 ? 37.630  -1.618  19.326  1.00 98.89  ? 128 CYS H SG  1 
ATOM   2538 N  N   . GLY B 2 129 ? 35.241  -2.527  22.506  1.00 72.64  ? 129 GLY H N   1 
ATOM   2539 C  CA  . GLY B 2 129 ? 35.549  -2.646  23.918  1.00 87.63  ? 129 GLY H CA  1 
ATOM   2540 C  C   . GLY B 2 129 ? 34.425  -3.317  24.679  1.00 88.07  ? 129 GLY H C   1 
ATOM   2541 O  O   . GLY B 2 129 ? 34.592  -3.708  25.836  1.00 91.42  ? 129 GLY H O   1 
ATOM   2542 N  N   . ASP B 2 130 ? 33.271  -3.444  24.030  1.00 85.58  ? 130 ASP H N   1 
ATOM   2543 C  CA  . ASP B 2 130 ? 32.141  -4.152  24.619  1.00 99.43  ? 130 ASP H CA  1 
ATOM   2544 C  C   . ASP B 2 130 ? 32.494  -5.635  24.723  1.00 108.34 ? 130 ASP H C   1 
ATOM   2545 O  O   . ASP B 2 130 ? 32.912  -6.255  23.743  1.00 107.88 ? 130 ASP H O   1 
ATOM   2546 C  CB  . ASP B 2 130 ? 30.870  -3.948  23.786  1.00 87.47  ? 130 ASP H CB  1 
ATOM   2547 C  CG  . ASP B 2 130 ? 29.664  -3.563  24.636  1.00 85.92  ? 130 ASP H CG  1 
ATOM   2548 O  OD1 . ASP B 2 130 ? 28.525  -3.919  24.256  1.00 77.82  ? 130 ASP H OD1 1 
ATOM   2549 O  OD2 . ASP B 2 130 ? 29.853  -2.899  25.680  1.00 82.14  ? 130 ASP H OD2 1 
ATOM   2550 N  N   . THR B 2 131 ? 32.328  -6.191  25.918  1.00 108.32 ? 131 THR H N   1 
ATOM   2551 C  CA  . THR B 2 131 ? 32.790  -7.543  26.224  1.00 116.96 ? 131 THR H CA  1 
ATOM   2552 C  C   . THR B 2 131 ? 31.868  -8.664  25.702  1.00 126.10 ? 131 THR H C   1 
ATOM   2553 O  O   . THR B 2 131 ? 30.671  -8.446  25.501  1.00 126.00 ? 131 THR H O   1 
ATOM   2554 C  CB  . THR B 2 131 ? 33.025  -7.701  27.753  1.00 114.64 ? 131 THR H CB  1 
ATOM   2555 O  OG1 . THR B 2 131 ? 32.086  -6.889  28.471  1.00 102.49 ? 131 THR H OG1 1 
ATOM   2556 C  CG2 . THR B 2 131 ? 34.439  -7.268  28.126  1.00 94.00  ? 131 THR H CG2 1 
ATOM   2557 N  N   . PRO B 2 132 ? 32.440  -9.864  25.462  1.00 127.65 ? 132 PRO H N   1 
ATOM   2558 C  CA  . PRO B 2 132 ? 31.769  -11.143 25.177  1.00 118.96 ? 132 PRO H CA  1 
ATOM   2559 C  C   . PRO B 2 132 ? 30.555  -11.414 26.096  1.00 120.41 ? 132 PRO H C   1 
ATOM   2560 O  O   . PRO B 2 132 ? 30.448  -10.757 27.133  1.00 121.35 ? 132 PRO H O   1 
ATOM   2561 C  CB  . PRO B 2 132 ? 32.899  -12.173 25.410  1.00 115.82 ? 132 PRO H CB  1 
ATOM   2562 C  CG  . PRO B 2 132 ? 34.110  -11.391 25.864  1.00 118.03 ? 132 PRO H CG  1 
ATOM   2563 C  CD  . PRO B 2 132 ? 33.899  -10.013 25.348  1.00 125.29 ? 132 PRO H CD  1 
ATOM   2564 N  N   . SER B 2 133 ? 29.670  -12.360 25.766  1.00 119.01 ? 133 SER H N   1 
ATOM   2565 C  CA  . SER B 2 133 ? 29.832  -13.321 24.674  1.00 110.99 ? 133 SER H CA  1 
ATOM   2566 C  C   . SER B 2 133 ? 28.500  -13.755 24.078  1.00 97.00  ? 133 SER H C   1 
ATOM   2567 O  O   . SER B 2 133 ? 27.488  -13.066 24.203  1.00 96.99  ? 133 SER H O   1 
ATOM   2568 C  CB  . SER B 2 133 ? 30.529  -14.575 25.204  1.00 110.80 ? 133 SER H CB  1 
ATOM   2569 O  OG  . SER B 2 133 ? 29.856  -15.079 26.347  1.00 114.90 ? 133 SER H OG  1 
ATOM   2570 N  N   . SER B 2 134 ? 28.533  -14.914 23.425  1.00 91.28  ? 134 SER H N   1 
ATOM   2571 C  CA  . SER B 2 134 ? 27.341  -15.630 22.969  1.00 84.91  ? 134 SER H CA  1 
ATOM   2572 C  C   . SER B 2 134 ? 26.547  -14.915 21.873  1.00 84.09  ? 134 SER H C   1 
ATOM   2573 O  O   . SER B 2 134 ? 26.609  -15.301 20.706  1.00 81.58  ? 134 SER H O   1 
ATOM   2574 C  CB  . SER B 2 134 ? 26.434  -15.993 24.151  1.00 85.96  ? 134 SER H CB  1 
ATOM   2575 O  OG  . SER B 2 134 ? 25.579  -17.073 23.818  1.00 94.07  ? 134 SER H OG  1 
ATOM   2576 N  N   . THR B 2 135 ? 25.786  -13.892 22.245  1.00 81.71  ? 135 THR H N   1 
ATOM   2577 C  CA  . THR B 2 135 ? 25.008  -13.153 21.259  1.00 72.15  ? 135 THR H CA  1 
ATOM   2578 C  C   . THR B 2 135 ? 25.584  -11.778 20.962  1.00 58.24  ? 135 THR H C   1 
ATOM   2579 O  O   . THR B 2 135 ? 26.419  -11.257 21.701  1.00 58.05  ? 135 THR H O   1 
ATOM   2580 C  CB  . THR B 2 135 ? 23.539  -12.978 21.686  1.00 68.43  ? 135 THR H CB  1 
ATOM   2581 O  OG1 . THR B 2 135 ? 23.451  -12.996 23.116  1.00 79.58  ? 135 THR H OG1 1 
ATOM   2582 C  CG2 . THR B 2 135 ? 22.679  -14.086 21.100  1.00 55.60  ? 135 THR H CG2 1 
ATOM   2583 N  N   . VAL B 2 136 ? 25.124  -11.201 19.862  1.00 45.08  ? 136 VAL H N   1 
ATOM   2584 C  CA  . VAL B 2 136 ? 25.460  -9.832  19.516  1.00 44.10  ? 136 VAL H CA  1 
ATOM   2585 C  C   . VAL B 2 136 ? 24.338  -9.255  18.650  1.00 38.70  ? 136 VAL H C   1 
ATOM   2586 O  O   . VAL B 2 136 ? 23.778  -9.937  17.784  1.00 31.48  ? 136 VAL H O   1 
ATOM   2587 C  CB  . VAL B 2 136 ? 26.847  -9.725  18.828  1.00 42.12  ? 136 VAL H CB  1 
ATOM   2588 C  CG1 . VAL B 2 136 ? 26.788  -10.201 17.385  1.00 41.11  ? 136 VAL H CG1 1 
ATOM   2589 C  CG2 . VAL B 2 136 ? 27.361  -8.303  18.891  1.00 39.85  ? 136 VAL H CG2 1 
ATOM   2590 N  N   . THR B 2 137 ? 23.974  -8.008  18.923  1.00 39.36  ? 137 THR H N   1 
ATOM   2591 C  CA  . THR B 2 137 ? 22.948  -7.341  18.135  1.00 33.10  ? 137 THR H CA  1 
ATOM   2592 C  C   . THR B 2 137 ? 23.617  -6.325  17.226  1.00 30.15  ? 137 THR H C   1 
ATOM   2593 O  O   . THR B 2 137 ? 24.356  -5.470  17.695  1.00 28.32  ? 137 THR H O   1 
ATOM   2594 C  CB  . THR B 2 137 ? 21.915  -6.638  19.029  1.00 30.56  ? 137 THR H CB  1 
ATOM   2595 O  OG1 . THR B 2 137 ? 21.248  -7.613  19.834  1.00 28.60  ? 137 THR H OG1 1 
ATOM   2596 C  CG2 . THR B 2 137 ? 20.881  -5.890  18.182  1.00 21.94  ? 137 THR H CG2 1 
ATOM   2597 N  N   . LEU B 2 138 ? 23.362  -6.445  15.925  1.00 31.70  ? 138 LEU H N   1 
ATOM   2598 C  CA  . LEU B 2 138 ? 23.929  -5.549  14.926  1.00 24.09  ? 138 LEU H CA  1 
ATOM   2599 C  C   . LEU B 2 138 ? 22.789  -4.856  14.196  1.00 27.08  ? 138 LEU H C   1 
ATOM   2600 O  O   . LEU B 2 138 ? 21.624  -5.256  14.335  1.00 27.49  ? 138 LEU H O   1 
ATOM   2601 C  CB  . LEU B 2 138 ? 24.792  -6.345  13.936  1.00 24.82  ? 138 LEU H CB  1 
ATOM   2602 C  CG  . LEU B 2 138 ? 25.930  -7.190  14.520  1.00 32.87  ? 138 LEU H CG  1 
ATOM   2603 C  CD1 . LEU B 2 138 ? 26.561  -8.098  13.447  1.00 32.19  ? 138 LEU H CD1 1 
ATOM   2604 C  CD2 . LEU B 2 138 ? 26.991  -6.300  15.179  1.00 27.97  ? 138 LEU H CD2 1 
ATOM   2605 N  N   . GLY B 2 139 ? 23.101  -3.823  13.411  1.00 25.41  ? 139 GLY H N   1 
ATOM   2606 C  CA  . GLY B 2 139 ? 22.040  -3.097  12.738  1.00 20.21  ? 139 GLY H CA  1 
ATOM   2607 C  C   . GLY B 2 139 ? 22.480  -2.134  11.653  1.00 24.63  ? 139 GLY H C   1 
ATOM   2608 O  O   . GLY B 2 139 ? 23.672  -1.986  11.381  1.00 21.18  ? 139 GLY H O   1 
ATOM   2609 N  N   . CYS B 2 140 ? 21.494  -1.504  11.016  1.00 22.10  ? 140 CYS H N   1 
ATOM   2610 C  CA  . CYS B 2 140 ? 21.733  -0.440  10.038  1.00 22.36  ? 140 CYS H CA  1 
ATOM   2611 C  C   . CYS B 2 140 ? 20.811  0.753   10.319  1.00 25.55  ? 140 CYS H C   1 
ATOM   2612 O  O   . CYS B 2 140 ? 19.604  0.587   10.524  1.00 22.77  ? 140 CYS H O   1 
ATOM   2613 C  CB  . CYS B 2 140 ? 21.490  -0.942  8.613   1.00 20.84  ? 140 CYS H CB  1 
ATOM   2614 S  SG  . CYS B 2 140 ? 22.763  -2.089  7.938   1.00 29.64  ? 140 CYS H SG  1 
ATOM   2615 N  N   . LEU B 2 141 ? 21.396  1.941   10.321  1.00 20.55  ? 141 LEU H N   1 
ATOM   2616 C  CA  . LEU B 2 141 ? 20.665  3.197   10.411  1.00 24.41  ? 141 LEU H CA  1 
ATOM   2617 C  C   . LEU B 2 141 ? 20.458  3.735   9.001   1.00 31.45  ? 141 LEU H C   1 
ATOM   2618 O  O   . LEU B 2 141 ? 21.415  3.872   8.226   1.00 22.39  ? 141 LEU H O   1 
ATOM   2619 C  CB  . LEU B 2 141 ? 21.452  4.201   11.258  1.00 22.58  ? 141 LEU H CB  1 
ATOM   2620 C  CG  . LEU B 2 141 ? 21.019  5.672   11.233  1.00 27.11  ? 141 LEU H CG  1 
ATOM   2621 C  CD1 . LEU B 2 141 ? 19.639  5.902   11.878  1.00 21.84  ? 141 LEU H CD1 1 
ATOM   2622 C  CD2 . LEU B 2 141 ? 22.080  6.518   11.913  1.00 24.32  ? 141 LEU H CD2 1 
ATOM   2623 N  N   . VAL B 2 142 ? 19.200  4.001   8.657   1.00 18.22  ? 142 VAL H N   1 
ATOM   2624 C  CA  . VAL B 2 142 ? 18.848  4.479   7.322   1.00 20.72  ? 142 VAL H CA  1 
ATOM   2625 C  C   . VAL B 2 142 ? 18.352  5.914   7.451   1.00 26.89  ? 142 VAL H C   1 
ATOM   2626 O  O   . VAL B 2 142 ? 17.311  6.163   8.051   1.00 25.93  ? 142 VAL H O   1 
ATOM   2627 C  CB  . VAL B 2 142 ? 17.747  3.605   6.698   1.00 25.92  ? 142 VAL H CB  1 
ATOM   2628 C  CG1 . VAL B 2 142 ? 17.412  4.095   5.296   1.00 21.55  ? 142 VAL H CG1 1 
ATOM   2629 C  CG2 . VAL B 2 142 ? 18.173  2.145   6.692   1.00 18.56  ? 142 VAL H CG2 1 
ATOM   2630 N  N   . LYS B 2 143 ? 19.093  6.858   6.883   1.00 24.93  ? 143 LYS H N   1 
ATOM   2631 C  CA  . LYS B 2 143 ? 18.950  8.252   7.265   1.00 25.96  ? 143 LYS H CA  1 
ATOM   2632 C  C   . LYS B 2 143 ? 18.775  9.185   6.061   1.00 24.79  ? 143 LYS H C   1 
ATOM   2633 O  O   . LYS B 2 143 ? 19.333  8.956   4.991   1.00 21.14  ? 143 LYS H O   1 
ATOM   2634 C  CB  . LYS B 2 143 ? 20.175  8.667   8.100   1.00 24.79  ? 143 LYS H CB  1 
ATOM   2635 C  CG  . LYS B 2 143 ? 20.151  10.085  8.625   1.00 36.08  ? 143 LYS H CG  1 
ATOM   2636 C  CD  . LYS B 2 143 ? 21.425  10.414  9.390   1.00 34.72  ? 143 LYS H CD  1 
ATOM   2637 C  CE  . LYS B 2 143 ? 21.388  11.851  9.909   1.00 36.93  ? 143 LYS H CE  1 
ATOM   2638 N  NZ  . LYS B 2 143 ? 22.555  12.135  10.788  1.00 48.86  ? 143 LYS H NZ  1 
ATOM   2639 N  N   . GLY B 2 144 ? 17.980  10.232  6.245   1.00 28.31  ? 144 GLY H N   1 
ATOM   2640 C  CA  . GLY B 2 144 ? 17.851  11.285  5.250   1.00 29.77  ? 144 GLY H CA  1 
ATOM   2641 C  C   . GLY B 2 144 ? 17.172  10.942  3.934   1.00 27.60  ? 144 GLY H C   1 
ATOM   2642 O  O   . GLY B 2 144 ? 17.607  11.425  2.893   1.00 30.22  ? 144 GLY H O   1 
ATOM   2643 N  N   . TYR B 2 145 ? 16.102  10.147  3.958   1.00 22.57  ? 145 TYR H N   1 
ATOM   2644 C  CA  . TYR B 2 145 ? 15.383  9.820   2.715   1.00 21.84  ? 145 TYR H CA  1 
ATOM   2645 C  C   . TYR B 2 145 ? 14.021  10.512  2.557   1.00 26.42  ? 145 TYR H C   1 
ATOM   2646 O  O   . TYR B 2 145 ? 13.403  10.939  3.535   1.00 21.65  ? 145 TYR H O   1 
ATOM   2647 C  CB  . TYR B 2 145 ? 15.225  8.306   2.536   1.00 20.05  ? 145 TYR H CB  1 
ATOM   2648 C  CG  . TYR B 2 145 ? 14.376  7.598   3.569   1.00 20.45  ? 145 TYR H CG  1 
ATOM   2649 C  CD1 . TYR B 2 145 ? 14.942  7.075   4.739   1.00 22.20  ? 145 TYR H CD1 1 
ATOM   2650 C  CD2 . TYR B 2 145 ? 13.015  7.402   3.355   1.00 22.82  ? 145 TYR H CD2 1 
ATOM   2651 C  CE1 . TYR B 2 145 ? 14.162  6.403   5.678   1.00 17.06  ? 145 TYR H CE1 1 
ATOM   2652 C  CE2 . TYR B 2 145 ? 12.231  6.727   4.283   1.00 18.73  ? 145 TYR H CE2 1 
ATOM   2653 C  CZ  . TYR B 2 145 ? 12.811  6.229   5.439   1.00 20.29  ? 145 TYR H CZ  1 
ATOM   2654 O  OH  . TYR B 2 145 ? 12.029  5.574   6.362   1.00 28.60  ? 145 TYR H OH  1 
ATOM   2655 N  N   . LEU B 2 146 ? 13.558  10.600  1.312   1.00 22.17  ? 146 LEU H N   1 
ATOM   2656 C  CA  . LEU B 2 146 ? 12.275  11.221  1.009   1.00 25.86  ? 146 LEU H CA  1 
ATOM   2657 C  C   . LEU B 2 146 ? 11.873  10.798  -0.387  1.00 26.79  ? 146 LEU H C   1 
ATOM   2658 O  O   . LEU B 2 146 ? 12.712  10.735  -1.270  1.00 24.51  ? 146 LEU H O   1 
ATOM   2659 C  CB  . LEU B 2 146 ? 12.393  12.752  1.068   1.00 25.47  ? 146 LEU H CB  1 
ATOM   2660 C  CG  . LEU B 2 146 ? 11.108  13.568  0.934   1.00 32.54  ? 146 LEU H CG  1 
ATOM   2661 C  CD1 . LEU B 2 146 ? 10.322  13.531  2.231   1.00 33.52  ? 146 LEU H CD1 1 
ATOM   2662 C  CD2 . LEU B 2 146 ? 11.411  15.008  0.533   1.00 42.57  ? 146 LEU H CD2 1 
ATOM   2663 N  N   . PRO B 2 147 ? 10.596  10.447  -0.583  1.00 25.41  ? 147 PRO H N   1 
ATOM   2664 C  CA  . PRO B 2 147 ? 9.582   10.242  0.448   1.00 29.27  ? 147 PRO H CA  1 
ATOM   2665 C  C   . PRO B 2 147 ? 9.643   8.812   0.982   1.00 29.20  ? 147 PRO H C   1 
ATOM   2666 O  O   . PRO B 2 147 ? 10.570  8.063   0.651   1.00 25.37  ? 147 PRO H O   1 
ATOM   2667 C  CB  . PRO B 2 147 ? 8.284   10.425  -0.333  1.00 27.52  ? 147 PRO H CB  1 
ATOM   2668 C  CG  . PRO B 2 147 ? 8.595   9.840   -1.658  1.00 25.10  ? 147 PRO H CG  1 
ATOM   2669 C  CD  . PRO B 2 147 ? 10.050  10.203  -1.930  1.00 24.24  ? 147 PRO H CD  1 
ATOM   2670 N  N   . GLU B 2 148 ? 8.660   8.443   1.800   1.00 22.67  ? 148 GLU H N   1 
ATOM   2671 C  CA  . GLU B 2 148 ? 8.508   7.062   2.249   1.00 24.25  ? 148 GLU H CA  1 
ATOM   2672 C  C   . GLU B 2 148 ? 7.999   6.198   1.107   1.00 28.79  ? 148 GLU H C   1 
ATOM   2673 O  O   . GLU B 2 148 ? 7.398   6.730   0.167   1.00 25.98  ? 148 GLU H O   1 
ATOM   2674 C  CB  . GLU B 2 148 ? 7.515   7.006   3.403   1.00 29.45  ? 148 GLU H CB  1 
ATOM   2675 C  CG  . GLU B 2 148 ? 8.065   7.487   4.707   1.00 29.85  ? 148 GLU H CG  1 
ATOM   2676 C  CD  . GLU B 2 148 ? 7.193   7.066   5.860   1.00 34.99  ? 148 GLU H CD  1 
ATOM   2677 O  OE1 . GLU B 2 148 ? 6.038   7.522   5.933   1.00 43.64  ? 148 GLU H OE1 1 
ATOM   2678 O  OE2 . GLU B 2 148 ? 7.659   6.260   6.680   1.00 42.00  ? 148 GLU H OE2 1 
ATOM   2679 N  N   . PRO B 2 149 ? 8.220   4.863   1.179   1.00 26.67  ? 149 PRO H N   1 
ATOM   2680 C  CA  . PRO B 2 149 ? 8.930   4.103   2.214   1.00 30.20  ? 149 PRO H CA  1 
ATOM   2681 C  C   . PRO B 2 149 ? 10.319  3.632   1.790   1.00 28.58  ? 149 PRO H C   1 
ATOM   2682 O  O   . PRO B 2 149 ? 10.735  3.835   0.654   1.00 24.78  ? 149 PRO H O   1 
ATOM   2683 C  CB  . PRO B 2 149 ? 8.055   2.858   2.352   1.00 32.92  ? 149 PRO H CB  1 
ATOM   2684 C  CG  . PRO B 2 149 ? 7.619   2.590   0.913   1.00 29.56  ? 149 PRO H CG  1 
ATOM   2685 C  CD  . PRO B 2 149 ? 7.566   3.952   0.218   1.00 25.77  ? 149 PRO H CD  1 
ATOM   2686 N  N   . VAL B 2 150 ? 11.032  3.008   2.721   1.00 24.87  ? 150 VAL H N   1 
ATOM   2687 C  CA  . VAL B 2 150 ? 12.159  2.156   2.362   1.00 29.07  ? 150 VAL H CA  1 
ATOM   2688 C  C   . VAL B 2 150 ? 11.782  0.739   2.803   1.00 28.38  ? 150 VAL H C   1 
ATOM   2689 O  O   . VAL B 2 150 ? 10.905  0.570   3.663   1.00 25.12  ? 150 VAL H O   1 
ATOM   2690 C  CB  . VAL B 2 150 ? 13.476  2.571   3.054   1.00 24.07  ? 150 VAL H CB  1 
ATOM   2691 C  CG1 . VAL B 2 150 ? 13.983  3.930   2.535   1.00 22.90  ? 150 VAL H CG1 1 
ATOM   2692 C  CG2 . VAL B 2 150 ? 13.307  2.586   4.558   1.00 26.41  ? 150 VAL H CG2 1 
ATOM   2693 N  N   . THR B 2 151 ? 12.419  -0.262  2.209   1.00 23.81  ? 151 THR H N   1 
ATOM   2694 C  CA  . THR B 2 151 ? 12.280  -1.640  2.654   1.00 27.50  ? 151 THR H CA  1 
ATOM   2695 C  C   . THR B 2 151 ? 13.647  -2.153  3.088   1.00 31.32  ? 151 THR H C   1 
ATOM   2696 O  O   . THR B 2 151 ? 14.656  -1.925  2.411   1.00 29.67  ? 151 THR H O   1 
ATOM   2697 C  CB  . THR B 2 151 ? 11.741  -2.556  1.525   1.00 30.68  ? 151 THR H CB  1 
ATOM   2698 O  OG1 . THR B 2 151 ? 12.631  -2.514  0.406   1.00 38.29  ? 151 THR H OG1 1 
ATOM   2699 C  CG2 . THR B 2 151 ? 10.366  -2.119  1.074   1.00 28.61  ? 151 THR H CG2 1 
ATOM   2700 N  N   . VAL B 2 152 ? 13.695  -2.830  4.225   1.00 22.61  ? 152 VAL H N   1 
ATOM   2701 C  CA  . VAL B 2 152 ? 14.953  -3.375  4.712   1.00 22.87  ? 152 VAL H CA  1 
ATOM   2702 C  C   . VAL B 2 152 ? 14.857  -4.894  4.822   1.00 30.13  ? 152 VAL H C   1 
ATOM   2703 O  O   . VAL B 2 152 ? 13.912  -5.410  5.400   1.00 25.71  ? 152 VAL H O   1 
ATOM   2704 C  CB  . VAL B 2 152 ? 15.315  -2.799  6.085   1.00 24.88  ? 152 VAL H CB  1 
ATOM   2705 C  CG1 . VAL B 2 152 ? 16.626  -3.376  6.569   1.00 21.87  ? 152 VAL H CG1 1 
ATOM   2706 C  CG2 . VAL B 2 152 ? 15.406  -1.268  6.014   1.00 25.32  ? 152 VAL H CG2 1 
ATOM   2707 N  N   . THR B 2 153 ? 15.823  -5.606  4.245   1.00 28.59  ? 153 THR H N   1 
ATOM   2708 C  CA  . THR B 2 153 ? 15.952  -7.040  4.480   1.00 24.47  ? 153 THR H CA  1 
ATOM   2709 C  C   . THR B 2 153 ? 17.354  -7.340  4.965   1.00 27.62  ? 153 THR H C   1 
ATOM   2710 O  O   . THR B 2 153 ? 18.245  -6.489  4.876   1.00 23.89  ? 153 THR H O   1 
ATOM   2711 C  CB  . THR B 2 153 ? 15.732  -7.878  3.200   1.00 27.97  ? 153 THR H CB  1 
ATOM   2712 O  OG1 . THR B 2 153 ? 16.681  -7.478  2.199   1.00 29.59  ? 153 THR H OG1 1 
ATOM   2713 C  CG2 . THR B 2 153 ? 14.305  -7.724  2.678   1.00 26.51  ? 153 THR H CG2 1 
ATOM   2714 N  N   . TRP B 2 154 ? 17.549  -8.560  5.463   1.00 24.22  ? 154 TRP H N   1 
ATOM   2715 C  CA  . TRP B 2 154 ? 18.862  -9.008  5.903   1.00 24.77  ? 154 TRP H CA  1 
ATOM   2716 C  C   . TRP B 2 154 ? 19.257  -10.273 5.143   1.00 30.48  ? 154 TRP H C   1 
ATOM   2717 O  O   . TRP B 2 154 ? 18.428  -11.171 4.953   1.00 29.24  ? 154 TRP H O   1 
ATOM   2718 C  CB  . TRP B 2 154 ? 18.872  -9.254  7.406   1.00 26.79  ? 154 TRP H CB  1 
ATOM   2719 C  CG  . TRP B 2 154 ? 18.793  -7.994  8.219   1.00 26.67  ? 154 TRP H CG  1 
ATOM   2720 C  CD1 . TRP B 2 154 ? 17.659  -7.377  8.664   1.00 25.24  ? 154 TRP H CD1 1 
ATOM   2721 C  CD2 . TRP B 2 154 ? 19.894  -7.194  8.667   1.00 21.03  ? 154 TRP H CD2 1 
ATOM   2722 N  NE1 . TRP B 2 154 ? 17.988  -6.244  9.373   1.00 25.77  ? 154 TRP H NE1 1 
ATOM   2723 C  CE2 . TRP B 2 154 ? 19.353  -6.112  9.393   1.00 23.50  ? 154 TRP H CE2 1 
ATOM   2724 C  CE3 . TRP B 2 154 ? 21.286  -7.295  8.545   1.00 21.10  ? 154 TRP H CE3 1 
ATOM   2725 C  CZ2 . TRP B 2 154 ? 20.152  -5.137  9.977   1.00 22.63  ? 154 TRP H CZ2 1 
ATOM   2726 C  CZ3 . TRP B 2 154 ? 22.073  -6.331  9.116   1.00 21.40  ? 154 TRP H CZ3 1 
ATOM   2727 C  CH2 . TRP B 2 154 ? 21.507  -5.255  9.820   1.00 25.45  ? 154 TRP H CH2 1 
ATOM   2728 N  N   . ASN B 2 155 ? 20.517  -10.324 4.716   1.00 28.93  ? 155 ASN H N   1 
ATOM   2729 C  CA  . ASN B 2 155 ? 21.017  -11.373 3.829   1.00 32.51  ? 155 ASN H CA  1 
ATOM   2730 C  C   . ASN B 2 155 ? 20.037  -11.765 2.730   1.00 35.86  ? 155 ASN H C   1 
ATOM   2731 O  O   . ASN B 2 155 ? 19.702  -12.942 2.568   1.00 37.12  ? 155 ASN H O   1 
ATOM   2732 C  CB  . ASN B 2 155 ? 21.470  -12.594 4.634   1.00 32.24  ? 155 ASN H CB  1 
ATOM   2733 C  CG  . ASN B 2 155 ? 22.617  -12.266 5.577   1.00 35.12  ? 155 ASN H CG  1 
ATOM   2734 O  OD1 . ASN B 2 155 ? 23.232  -11.200 5.478   1.00 37.76  ? 155 ASN H OD1 1 
ATOM   2735 N  ND2 . ASN B 2 155 ? 22.922  -13.190 6.492   1.00 32.39  ? 155 ASN H ND2 1 
ATOM   2736 N  N   . SER B 2 156 ? 19.566  -10.754 2.002   1.00 32.29  ? 156 SER H N   1 
ATOM   2737 C  CA  . SER B 2 156 ? 18.640  -10.925 0.882   1.00 31.32  ? 156 SER H CA  1 
ATOM   2738 C  C   . SER B 2 156 ? 17.365  -11.685 1.243   1.00 35.19  ? 156 SER H C   1 
ATOM   2739 O  O   . SER B 2 156 ? 16.762  -12.339 0.395   1.00 35.66  ? 156 SER H O   1 
ATOM   2740 C  CB  . SER B 2 156 ? 19.355  -11.561 -0.317  1.00 33.56  ? 156 SER H CB  1 
ATOM   2741 O  OG  . SER B 2 156 ? 20.548  -10.844 -0.623  1.00 35.36  ? 156 SER H OG  1 
ATOM   2742 N  N   . GLY B 2 157 ? 16.949  -11.588 2.500   1.00 30.57  ? 157 GLY H N   1 
ATOM   2743 C  CA  . GLY B 2 157 ? 15.690  -12.182 2.914   1.00 32.29  ? 157 GLY H CA  1 
ATOM   2744 C  C   . GLY B 2 157 ? 15.819  -13.562 3.534   1.00 35.01  ? 157 GLY H C   1 
ATOM   2745 O  O   . GLY B 2 157 ? 14.815  -14.168 3.900   1.00 36.90  ? 157 GLY H O   1 
ATOM   2746 N  N   . THR B 2 158 ? 17.044  -14.063 3.664   1.00 40.51  ? 158 THR H N   1 
ATOM   2747 C  CA  . THR B 2 158 ? 17.255  -15.388 4.253   1.00 38.36  ? 158 THR H CA  1 
ATOM   2748 C  C   . THR B 2 158 ? 17.419  -15.312 5.771   1.00 42.66  ? 158 THR H C   1 
ATOM   2749 O  O   . THR B 2 158 ? 17.322  -16.327 6.467   1.00 37.81  ? 158 THR H O   1 
ATOM   2750 C  CB  . THR B 2 158 ? 18.477  -16.109 3.647   1.00 35.26  ? 158 THR H CB  1 
ATOM   2751 O  OG1 . THR B 2 158 ? 19.680  -15.411 3.996   1.00 35.86  ? 158 THR H OG1 1 
ATOM   2752 C  CG2 . THR B 2 158 ? 18.351  -16.209 2.129   1.00 30.76  ? 158 THR H CG2 1 
ATOM   2753 N  N   . LEU B 2 159 ? 17.677  -14.108 6.276   1.00 36.09  ? 159 LEU H N   1 
ATOM   2754 C  CA  . LEU B 2 159 ? 17.763  -13.875 7.718   1.00 34.60  ? 159 LEU H CA  1 
ATOM   2755 C  C   . LEU B 2 159 ? 16.509  -13.136 8.165   1.00 42.14  ? 159 LEU H C   1 
ATOM   2756 O  O   . LEU B 2 159 ? 16.292  -11.971 7.817   1.00 38.22  ? 159 LEU H O   1 
ATOM   2757 C  CB  . LEU B 2 159 ? 19.027  -13.088 8.074   1.00 38.09  ? 159 LEU H CB  1 
ATOM   2758 C  CG  . LEU B 2 159 ? 19.263  -12.757 9.547   1.00 36.12  ? 159 LEU H CG  1 
ATOM   2759 C  CD1 . LEU B 2 159 ? 19.006  -13.974 10.412  1.00 43.61  ? 159 LEU H CD1 1 
ATOM   2760 C  CD2 . LEU B 2 159 ? 20.687  -12.258 9.757   1.00 30.52  ? 159 LEU H CD2 1 
ATOM   2761 N  N   . THR B 2 160 ? 15.692  -13.825 8.949   1.00 43.12  ? 160 THR H N   1 
ATOM   2762 C  CA  . THR B 2 160 ? 14.311  -13.430 9.171   1.00 38.63  ? 160 THR H CA  1 
ATOM   2763 C  C   . THR B 2 160 ? 13.983  -13.315 10.662  1.00 44.46  ? 160 THR H C   1 
ATOM   2764 O  O   . THR B 2 160 ? 13.240  -12.419 11.085  1.00 41.69  ? 160 THR H O   1 
ATOM   2765 C  CB  . THR B 2 160 ? 13.377  -14.474 8.510   1.00 51.55  ? 160 THR H CB  1 
ATOM   2766 O  OG1 . THR B 2 160 ? 12.029  -14.276 8.942   1.00 55.27  ? 160 THR H OG1 1 
ATOM   2767 C  CG2 . THR B 2 160 ? 13.818  -15.897 8.876   1.00 49.95  ? 160 THR H CG2 1 
ATOM   2768 N  N   . ASN B 2 161 ? 14.543  -14.226 11.454  1.00 36.82  ? 161 ASN H N   1 
ATOM   2769 C  CA  . ASN B 2 161 ? 14.277  -14.263 12.885  1.00 47.35  ? 161 ASN H CA  1 
ATOM   2770 C  C   . ASN B 2 161 ? 15.192  -13.326 13.651  1.00 40.79  ? 161 ASN H C   1 
ATOM   2771 O  O   . ASN B 2 161 ? 16.385  -13.235 13.361  1.00 41.34  ? 161 ASN H O   1 
ATOM   2772 C  CB  . ASN B 2 161 ? 14.452  -15.683 13.431  1.00 45.59  ? 161 ASN H CB  1 
ATOM   2773 C  CG  . ASN B 2 161 ? 13.491  -16.678 12.800  1.00 53.83  ? 161 ASN H CG  1 
ATOM   2774 O  OD1 . ASN B 2 161 ? 12.300  -16.399 12.632  1.00 54.78  ? 161 ASN H OD1 1 
ATOM   2775 N  ND2 . ASN B 2 161 ? 14.010  -17.850 12.443  1.00 47.44  ? 161 ASN H ND2 1 
ATOM   2776 N  N   . GLY B 2 162 ? 14.634  -12.646 14.643  1.00 33.88  ? 162 GLY H N   1 
ATOM   2777 C  CA  . GLY B 2 162 ? 15.436  -11.797 15.502  1.00 38.82  ? 162 GLY H CA  1 
ATOM   2778 C  C   . GLY B 2 162 ? 15.680  -10.437 14.879  1.00 38.82  ? 162 GLY H C   1 
ATOM   2779 O  O   . GLY B 2 162 ? 16.632  -9.743  15.251  1.00 37.43  ? 162 GLY H O   1 
ATOM   2780 N  N   . VAL B 2 163 ? 14.815  -10.061 13.937  1.00 34.75  ? 163 VAL H N   1 
ATOM   2781 C  CA  . VAL B 2 163 ? 14.911  -8.770  13.256  1.00 31.48  ? 163 VAL H CA  1 
ATOM   2782 C  C   . VAL B 2 163 ? 13.870  -7.785  13.779  1.00 32.70  ? 163 VAL H C   1 
ATOM   2783 O  O   . VAL B 2 163 ? 12.678  -8.090  13.801  1.00 28.81  ? 163 VAL H O   1 
ATOM   2784 C  CB  . VAL B 2 163 ? 14.707  -8.925  11.734  1.00 31.12  ? 163 VAL H CB  1 
ATOM   2785 C  CG1 . VAL B 2 163 ? 14.685  -7.552  11.053  1.00 34.31  ? 163 VAL H CG1 1 
ATOM   2786 C  CG2 . VAL B 2 163 ? 15.795  -9.784  11.142  1.00 30.55  ? 163 VAL H CG2 1 
ATOM   2787 N  N   . ARG B 2 164 ? 14.316  -6.606  14.209  1.00 28.52  ? 164 ARG H N   1 
ATOM   2788 C  CA  . ARG B 2 164 ? 13.384  -5.546  14.587  1.00 28.79  ? 164 ARG H CA  1 
ATOM   2789 C  C   . ARG B 2 164 ? 13.629  -4.329  13.708  1.00 27.73  ? 164 ARG H C   1 
ATOM   2790 O  O   . ARG B 2 164 ? 14.719  -3.767  13.721  1.00 20.97  ? 164 ARG H O   1 
ATOM   2791 C  CB  . ARG B 2 164 ? 13.557  -5.141  16.050  1.00 27.68  ? 164 ARG H CB  1 
ATOM   2792 C  CG  . ARG B 2 164 ? 12.895  -6.069  17.061  1.00 36.07  ? 164 ARG H CG  1 
ATOM   2793 C  CD  . ARG B 2 164 ? 13.887  -7.075  17.577  1.00 39.35  ? 164 ARG H CD  1 
ATOM   2794 N  NE  . ARG B 2 164 ? 14.873  -6.480  18.476  1.00 47.92  ? 164 ARG H NE  1 
ATOM   2795 C  CZ  . ARG B 2 164 ? 16.112  -6.945  18.637  1.00 49.32  ? 164 ARG H CZ  1 
ATOM   2796 N  NH1 . ARG B 2 164 ? 16.945  -6.348  19.491  1.00 38.08  ? 164 ARG H NH1 1 
ATOM   2797 N  NH2 . ARG B 2 164 ? 16.519  -8.005  17.942  1.00 43.55  ? 164 ARG H NH2 1 
ATOM   2798 N  N   . THR B 2 165 ? 12.614  -3.939  12.945  1.00 22.58  ? 165 THR H N   1 
ATOM   2799 C  CA  . THR B 2 165 ? 12.708  -2.754  12.087  1.00 25.76  ? 165 THR H CA  1 
ATOM   2800 C  C   . THR B 2 165 ? 11.710  -1.719  12.563  1.00 21.54  ? 165 THR H C   1 
ATOM   2801 O  O   . THR B 2 165 ? 10.492  -1.902  12.435  1.00 27.81  ? 165 THR H O   1 
ATOM   2802 C  CB  . THR B 2 165 ? 12.445  -3.105  10.615  1.00 30.93  ? 165 THR H CB  1 
ATOM   2803 O  OG1 . THR B 2 165 ? 13.395  -4.093  10.194  1.00 24.92  ? 165 THR H OG1 1 
ATOM   2804 C  CG2 . THR B 2 165 ? 12.567  -1.855  9.721   1.00 25.66  ? 165 THR H CG2 1 
ATOM   2805 N  N   . PHE B 2 166 ? 12.232  -0.650  13.138  1.00 22.37  ? 166 PHE H N   1 
ATOM   2806 C  CA  . PHE B 2 166 ? 11.406  0.355   13.794  1.00 21.75  ? 166 PHE H CA  1 
ATOM   2807 C  C   . PHE B 2 166 ? 10.665  1.214   12.777  1.00 25.19  ? 166 PHE H C   1 
ATOM   2808 O  O   . PHE B 2 166 ? 11.117  1.368   11.634  1.00 22.13  ? 166 PHE H O   1 
ATOM   2809 C  CB  . PHE B 2 166 ? 12.268  1.190   14.742  1.00 19.72  ? 166 PHE H CB  1 
ATOM   2810 C  CG  . PHE B 2 166 ? 12.895  0.379   15.833  1.00 22.98  ? 166 PHE H CG  1 
ATOM   2811 C  CD1 . PHE B 2 166 ? 12.221  0.170   17.035  1.00 21.93  ? 166 PHE H CD1 1 
ATOM   2812 C  CD2 . PHE B 2 166 ? 14.143  -0.207  15.655  1.00 20.88  ? 166 PHE H CD2 1 
ATOM   2813 C  CE1 . PHE B 2 166 ? 12.798  -0.604  18.058  1.00 15.99  ? 166 PHE H CE1 1 
ATOM   2814 C  CE2 . PHE B 2 166 ? 14.715  -0.980  16.661  1.00 23.61  ? 166 PHE H CE2 1 
ATOM   2815 C  CZ  . PHE B 2 166 ? 14.039  -1.173  17.865  1.00 22.55  ? 166 PHE H CZ  1 
ATOM   2816 N  N   . PRO B 2 167 ? 9.492   1.737   13.170  1.00 20.14  ? 167 PRO H N   1 
ATOM   2817 C  CA  . PRO B 2 167 ? 8.768   2.630   12.260  1.00 24.90  ? 167 PRO H CA  1 
ATOM   2818 C  C   . PRO B 2 167 ? 9.596   3.889   11.990  1.00 22.17  ? 167 PRO H C   1 
ATOM   2819 O  O   . PRO B 2 167 ? 10.375  4.313   12.834  1.00 19.96  ? 167 PRO H O   1 
ATOM   2820 C  CB  . PRO B 2 167 ? 7.480   2.964   13.036  1.00 27.21  ? 167 PRO H CB  1 
ATOM   2821 C  CG  . PRO B 2 167 ? 7.349   1.849   14.060  1.00 25.61  ? 167 PRO H CG  1 
ATOM   2822 C  CD  . PRO B 2 167 ? 8.760   1.503   14.427  1.00 23.62  ? 167 PRO H CD  1 
ATOM   2823 N  N   . SER B 2 168 ? 9.448   4.460   10.806  1.00 17.00  ? 168 SER H N   1 
ATOM   2824 C  CA  . SER B 2 168 ? 10.228  5.632   10.444  1.00 24.13  ? 168 SER H CA  1 
ATOM   2825 C  C   . SER B 2 168 ? 9.788   6.814   11.285  1.00 26.39  ? 168 SER H C   1 
ATOM   2826 O  O   . SER B 2 168 ? 8.688   6.799   11.842  1.00 24.38  ? 168 SER H O   1 
ATOM   2827 C  CB  . SER B 2 168 ? 10.001  5.968   8.978   1.00 28.09  ? 168 SER H CB  1 
ATOM   2828 O  OG  . SER B 2 168 ? 8.664   6.380   8.788   1.00 35.25  ? 168 SER H OG  1 
ATOM   2829 N  N   . VAL B 2 169 ? 10.657  7.820   11.393  1.00 25.83  ? 169 VAL H N   1 
ATOM   2830 C  CA  . VAL B 2 169 ? 10.298  9.109   11.988  1.00 25.57  ? 169 VAL H CA  1 
ATOM   2831 C  C   . VAL B 2 169 ? 10.738  10.229  11.045  1.00 27.08  ? 169 VAL H C   1 
ATOM   2832 O  O   . VAL B 2 169 ? 11.802  10.144  10.436  1.00 27.84  ? 169 VAL H O   1 
ATOM   2833 C  CB  . VAL B 2 169 ? 10.949  9.338   13.376  1.00 33.01  ? 169 VAL H CB  1 
ATOM   2834 C  CG1 . VAL B 2 169 ? 10.422  8.347   14.395  1.00 35.23  ? 169 VAL H CG1 1 
ATOM   2835 C  CG2 . VAL B 2 169 ? 12.466  9.262   13.285  1.00 38.44  ? 169 VAL H CG2 1 
ATOM   2836 N  N   . ARG B 2 170 ? 9.898   11.247  10.897  1.00 33.48  ? 170 ARG H N   1 
ATOM   2837 C  CA  . ARG B 2 170 ? 10.205  12.405  10.061  1.00 29.77  ? 170 ARG H CA  1 
ATOM   2838 C  C   . ARG B 2 170 ? 11.004  13.379  10.922  1.00 37.91  ? 170 ARG H C   1 
ATOM   2839 O  O   . ARG B 2 170 ? 10.446  14.007  11.820  1.00 40.40  ? 170 ARG H O   1 
ATOM   2840 C  CB  . ARG B 2 170 ? 8.907   13.033  9.542   1.00 34.97  ? 170 ARG H CB  1 
ATOM   2841 C  CG  . ARG B 2 170 ? 9.062   14.160  8.518   1.00 33.75  ? 170 ARG H CG  1 
ATOM   2842 C  CD  . ARG B 2 170 ? 7.731   14.371  7.791   1.00 47.89  ? 170 ARG H CD  1 
ATOM   2843 N  NE  . ARG B 2 170 ? 7.650   15.668  7.127   1.00 61.76  ? 170 ARG H NE  1 
ATOM   2844 C  CZ  . ARG B 2 170 ? 7.480   15.837  5.818   1.00 65.51  ? 170 ARG H CZ  1 
ATOM   2845 N  NH1 . ARG B 2 170 ? 7.365   14.787  5.010   1.00 61.73  ? 170 ARG H NH1 1 
ATOM   2846 N  NH2 . ARG B 2 170 ? 7.417   17.064  5.317   1.00 62.94  ? 170 ARG H NH2 1 
ATOM   2847 N  N   . GLN B 2 171 ? 12.321  13.449  10.684  1.00 30.87  ? 171 GLN H N   1 
ATOM   2848 C  CA  . GLN B 2 171 ? 13.257  14.264  11.478  1.00 32.91  ? 171 GLN H CA  1 
ATOM   2849 C  C   . GLN B 2 171 ? 13.120  15.779  11.252  1.00 36.47  ? 171 GLN H C   1 
ATOM   2850 O  O   . GLN B 2 171 ? 12.330  16.217  10.412  1.00 35.39  ? 171 GLN H O   1 
ATOM   2851 C  CB  . GLN B 2 171 ? 14.703  13.847  11.191  1.00 36.55  ? 171 GLN H CB  1 
ATOM   2852 C  CG  . GLN B 2 171 ? 14.999  12.354  11.396  1.00 46.56  ? 171 GLN H CG  1 
ATOM   2853 C  CD  . GLN B 2 171 ? 15.604  12.032  12.760  1.00 44.43  ? 171 GLN H CD  1 
ATOM   2854 O  OE1 . GLN B 2 171 ? 16.180  12.896  13.427  1.00 43.41  ? 171 GLN H OE1 1 
ATOM   2855 N  NE2 . GLN B 2 171 ? 15.474  10.776  13.178  1.00 53.57  ? 171 GLN H NE2 1 
ATOM   2856 N  N   . SER B 2 172 ? 13.901  16.568  11.995  1.00 35.13  ? 172 SER H N   1 
ATOM   2857 C  CA  . SER B 2 172 ? 13.769  18.036  11.988  1.00 38.45  ? 172 SER H CA  1 
ATOM   2858 C  C   . SER B 2 172 ? 14.177  18.640  10.646  1.00 39.13  ? 172 SER H C   1 
ATOM   2859 O  O   . SER B 2 172 ? 13.784  19.758  10.310  1.00 37.72  ? 172 SER H O   1 
ATOM   2860 C  CB  . SER B 2 172 ? 14.589  18.675  13.118  1.00 37.91  ? 172 SER H CB  1 
ATOM   2861 O  OG  . SER B 2 172 ? 15.927  18.920  12.712  1.00 36.52  ? 172 SER H OG  1 
ATOM   2862 N  N   . SER B 2 173 ? 14.975  17.890  9.894   1.00 37.46  ? 173 SER H N   1 
ATOM   2863 C  CA  . SER B 2 173 ? 15.383  18.276  8.557   1.00 29.33  ? 173 SER H CA  1 
ATOM   2864 C  C   . SER B 2 173 ? 14.255  18.172  7.526   1.00 31.72  ? 173 SER H C   1 
ATOM   2865 O  O   . SER B 2 173 ? 14.378  18.718  6.432   1.00 35.39  ? 173 SER H O   1 
ATOM   2866 C  CB  . SER B 2 173 ? 16.530  17.374  8.094   1.00 38.67  ? 173 SER H CB  1 
ATOM   2867 O  OG  . SER B 2 173 ? 16.081  16.028  7.996   1.00 29.72  ? 173 SER H OG  1 
ATOM   2868 N  N   . GLY B 2 174 ? 13.186  17.445  7.852   1.00 34.72  ? 174 GLY H N   1 
ATOM   2869 C  CA  . GLY B 2 174 ? 12.106  17.177  6.906   1.00 29.80  ? 174 GLY H CA  1 
ATOM   2870 C  C   . GLY B 2 174 ? 12.222  15.826  6.200   1.00 28.60  ? 174 GLY H C   1 
ATOM   2871 O  O   . GLY B 2 174 ? 11.338  15.399  5.478   1.00 27.98  ? 174 GLY H O   1 
ATOM   2872 N  N   . LEU B 2 175 ? 13.333  15.149  6.425   1.00 29.81  ? 175 LEU H N   1 
ATOM   2873 C  CA  . LEU B 2 175 ? 13.659  13.868  5.794   1.00 28.86  ? 175 LEU H CA  1 
ATOM   2874 C  C   . LEU B 2 175 ? 13.400  12.735  6.777   1.00 23.91  ? 175 LEU H C   1 
ATOM   2875 O  O   . LEU B 2 175 ? 13.326  12.974  7.973   1.00 31.26  ? 175 LEU H O   1 
ATOM   2876 C  CB  . LEU B 2 175 ? 15.132  13.888  5.416   1.00 27.53  ? 175 LEU H CB  1 
ATOM   2877 C  CG  . LEU B 2 175 ? 15.542  15.069  4.522   1.00 33.06  ? 175 LEU H CG  1 
ATOM   2878 C  CD1 . LEU B 2 175 ? 17.059  15.117  4.375   1.00 31.21  ? 175 LEU H CD1 1 
ATOM   2879 C  CD2 . LEU B 2 175 ? 14.867  14.977  3.156   1.00 30.22  ? 175 LEU H CD2 1 
ATOM   2880 N  N   . TYR B 2 176 ? 13.274  11.509  6.287   1.00 20.79  ? 176 TYR H N   1 
ATOM   2881 C  CA  . TYR B 2 176 ? 12.939  10.387  7.165   1.00 23.29  ? 176 TYR H CA  1 
ATOM   2882 C  C   . TYR B 2 176 ? 14.151  9.591   7.631   1.00 25.23  ? 176 TYR H C   1 
ATOM   2883 O  O   . TYR B 2 176 ? 15.197  9.548   6.974   1.00 23.30  ? 176 TYR H O   1 
ATOM   2884 C  CB  . TYR B 2 176 ? 11.945  9.444   6.479   1.00 19.88  ? 176 TYR H CB  1 
ATOM   2885 C  CG  . TYR B 2 176 ? 10.569  10.043  6.326   1.00 25.65  ? 176 TYR H CG  1 
ATOM   2886 C  CD1 . TYR B 2 176 ? 9.581   9.822   7.287   1.00 26.28  ? 176 TYR H CD1 1 
ATOM   2887 C  CD2 . TYR B 2 176 ? 10.252  10.830  5.222   1.00 25.07  ? 176 TYR H CD2 1 
ATOM   2888 C  CE1 . TYR B 2 176 ? 8.301   10.372  7.144   1.00 29.65  ? 176 TYR H CE1 1 
ATOM   2889 C  CE2 . TYR B 2 176 ? 8.983   11.377  5.072   1.00 26.42  ? 176 TYR H CE2 1 
ATOM   2890 C  CZ  . TYR B 2 176 ? 8.014   11.145  6.039   1.00 33.95  ? 176 TYR H CZ  1 
ATOM   2891 O  OH  . TYR B 2 176 ? 6.753   11.689  5.897   1.00 39.62  ? 176 TYR H OH  1 
ATOM   2892 N  N   . SER B 2 177 ? 13.994  8.929   8.763   1.00 20.42  ? 177 SER H N   1 
ATOM   2893 C  CA  . SER B 2 177 ? 15.028  8.057   9.256   1.00 24.54  ? 177 SER H CA  1 
ATOM   2894 C  C   . SER B 2 177 ? 14.416  6.843   9.970   1.00 22.26  ? 177 SER H C   1 
ATOM   2895 O  O   . SER B 2 177 ? 13.384  6.952   10.620  1.00 21.27  ? 177 SER H O   1 
ATOM   2896 C  CB  . SER B 2 177 ? 15.918  8.840   10.213  1.00 28.44  ? 177 SER H CB  1 
ATOM   2897 O  OG  . SER B 2 177 ? 17.020  8.059   10.597  1.00 38.19  ? 177 SER H OG  1 
ATOM   2898 N  N   . LEU B 2 178 ? 15.045  5.686   9.823   1.00 26.95  ? 178 LEU H N   1 
ATOM   2899 C  CA  . LEU B 2 178 ? 14.716  4.534   10.653  1.00 27.39  ? 178 LEU H CA  1 
ATOM   2900 C  C   . LEU B 2 178 ? 15.944  3.680   10.910  1.00 26.83  ? 178 LEU H C   1 
ATOM   2901 O  O   . LEU B 2 178 ? 16.978  3.849   10.252  1.00 21.74  ? 178 LEU H O   1 
ATOM   2902 C  CB  . LEU B 2 178 ? 13.582  3.700   10.036  1.00 24.54  ? 178 LEU H CB  1 
ATOM   2903 C  CG  . LEU B 2 178 ? 13.737  2.933   8.721   1.00 28.07  ? 178 LEU H CG  1 
ATOM   2904 C  CD1 . LEU B 2 178 ? 14.613  1.689   8.832   1.00 23.65  ? 178 LEU H CD1 1 
ATOM   2905 C  CD2 . LEU B 2 178 ? 12.344  2.532   8.205   1.00 30.77  ? 178 LEU H CD2 1 
ATOM   2906 N  N   . SER B 2 179 ? 15.810  2.756   11.859  1.00 25.08  ? 179 SER H N   1 
ATOM   2907 C  CA  . SER B 2 179 ? 16.847  1.776   12.183  1.00 23.62  ? 179 SER H CA  1 
ATOM   2908 C  C   . SER B 2 179 ? 16.299  0.358   12.075  1.00 23.01  ? 179 SER H C   1 
ATOM   2909 O  O   . SER B 2 179 ? 15.121  0.128   12.313  1.00 17.65  ? 179 SER H O   1 
ATOM   2910 C  CB  . SER B 2 179 ? 17.356  1.987   13.607  1.00 24.90  ? 179 SER H CB  1 
ATOM   2911 O  OG  . SER B 2 179 ? 18.324  3.022   13.659  1.00 38.64  ? 179 SER H OG  1 
ATOM   2912 N  N   . SER B 2 180 ? 17.156  -0.585  11.699  1.00 22.29  ? 180 SER H N   1 
ATOM   2913 C  CA  . SER B 2 180 ? 16.803  -2.002  11.759  1.00 26.55  ? 180 SER H CA  1 
ATOM   2914 C  C   . SER B 2 180 ? 17.927  -2.731  12.466  1.00 23.39  ? 180 SER H C   1 
ATOM   2915 O  O   . SER B 2 180 ? 19.095  -2.497  12.161  1.00 23.90  ? 180 SER H O   1 
ATOM   2916 C  CB  . SER B 2 180 ? 16.583  -2.581  10.356  1.00 25.13  ? 180 SER H CB  1 
ATOM   2917 O  OG  . SER B 2 180 ? 16.253  -3.968  10.401  1.00 24.53  ? 180 SER H OG  1 
ATOM   2918 N  N   . VAL B 2 181 ? 17.581  -3.591  13.422  1.00 19.85  ? 181 VAL H N   1 
ATOM   2919 C  CA  . VAL B 2 181 ? 18.591  -4.355  14.153  1.00 20.05  ? 181 VAL H CA  1 
ATOM   2920 C  C   . VAL B 2 181 ? 18.276  -5.854  14.136  1.00 26.70  ? 181 VAL H C   1 
ATOM   2921 O  O   . VAL B 2 181 ? 17.119  -6.265  13.975  1.00 28.08  ? 181 VAL H O   1 
ATOM   2922 C  CB  . VAL B 2 181 ? 18.731  -3.910  15.632  1.00 20.97  ? 181 VAL H CB  1 
ATOM   2923 C  CG1 . VAL B 2 181 ? 19.161  -2.456  15.724  1.00 19.76  ? 181 VAL H CG1 1 
ATOM   2924 C  CG2 . VAL B 2 181 ? 17.433  -4.158  16.389  1.00 24.43  ? 181 VAL H CG2 1 
ATOM   2925 N  N   . VAL B 2 182 ? 19.309  -6.665  14.321  1.00 23.22  ? 182 VAL H N   1 
ATOM   2926 C  CA  . VAL B 2 182 ? 19.158  -8.119  14.277  1.00 25.24  ? 182 VAL H CA  1 
ATOM   2927 C  C   . VAL B 2 182 ? 20.124  -8.797  15.261  1.00 25.32  ? 182 VAL H C   1 
ATOM   2928 O  O   . VAL B 2 182 ? 21.296  -8.440  15.361  1.00 27.98  ? 182 VAL H O   1 
ATOM   2929 C  CB  . VAL B 2 182 ? 19.351  -8.688  12.836  1.00 25.50  ? 182 VAL H CB  1 
ATOM   2930 C  CG1 . VAL B 2 182 ? 20.742  -8.363  12.290  1.00 26.08  ? 182 VAL H CG1 1 
ATOM   2931 C  CG2 . VAL B 2 182 ? 19.108  -10.210 12.802  1.00 30.34  ? 182 VAL H CG2 1 
ATOM   2932 N  N   . SER B 2 183 ? 19.610  -9.778  15.987  1.00 28.87  ? 183 SER H N   1 
ATOM   2933 C  CA  . SER B 2 183 ? 20.398  -10.482 16.978  1.00 34.81  ? 183 SER H CA  1 
ATOM   2934 C  C   . SER B 2 183 ? 20.962  -11.738 16.341  1.00 35.49  ? 183 SER H C   1 
ATOM   2935 O  O   . SER B 2 183 ? 20.245  -12.531 15.733  1.00 33.90  ? 183 SER H O   1 
ATOM   2936 C  CB  . SER B 2 183 ? 19.536  -10.841 18.184  1.00 32.54  ? 183 SER H CB  1 
ATOM   2937 O  OG  . SER B 2 183 ? 18.981  -9.676  18.767  1.00 46.23  ? 183 SER H OG  1 
ATOM   2938 N  N   . VAL B 2 184 ? 22.261  -11.913 16.491  1.00 30.95  ? 184 VAL H N   1 
ATOM   2939 C  CA  . VAL B 2 184 ? 22.969  -12.935 15.763  1.00 49.48  ? 184 VAL H CA  1 
ATOM   2940 C  C   . VAL B 2 184 ? 23.984  -13.595 16.694  1.00 56.59  ? 184 VAL H C   1 
ATOM   2941 O  O   . VAL B 2 184 ? 24.654  -12.911 17.468  1.00 51.93  ? 184 VAL H O   1 
ATOM   2942 C  CB  . VAL B 2 184 ? 23.618  -12.244 14.547  1.00 50.09  ? 184 VAL H CB  1 
ATOM   2943 C  CG1 . VAL B 2 184 ? 25.127  -12.482 14.437  1.00 49.08  ? 184 VAL H CG1 1 
ATOM   2944 C  CG2 . VAL B 2 184 ? 22.790  -12.402 13.276  1.00 47.80  ? 184 VAL H CG2 1 
ATOM   2945 N  N   . THR B 2 185 ? 24.065  -14.923 16.638  1.00 61.77  ? 185 THR H N   1 
ATOM   2946 C  CA  . THR B 2 185 ? 24.933  -15.679 17.536  1.00 69.34  ? 185 THR H CA  1 
ATOM   2947 C  C   . THR B 2 185 ? 26.392  -15.169 17.314  1.00 73.53  ? 185 THR H C   1 
ATOM   2948 O  O   . THR B 2 185 ? 26.966  -15.249 16.203  1.00 75.47  ? 185 THR H O   1 
ATOM   2949 C  CB  . THR B 2 185 ? 24.795  -17.188 17.296  1.00 60.28  ? 185 THR H CB  1 
ATOM   2950 O  OG1 . THR B 2 185 ? 24.910  -17.477 15.895  1.00 59.60  ? 185 THR H OG1 1 
ATOM   2951 C  CG2 . THR B 2 185 ? 23.435  -17.668 17.784  1.00 56.56  ? 185 THR H CG2 1 
ATOM   2952 N  N   . SER B 2 186 ? 26.986  -14.624 18.379  1.00 77.84  ? 186 SER H N   1 
ATOM   2953 C  CA  . SER B 2 186 ? 28.152  -13.716 18.279  1.00 73.88  ? 186 SER H CA  1 
ATOM   2954 C  C   . SER B 2 186 ? 29.384  -14.302 17.591  1.00 81.75  ? 186 SER H C   1 
ATOM   2955 O  O   . SER B 2 186 ? 29.605  -15.514 17.614  1.00 86.74  ? 186 SER H O   1 
ATOM   2956 C  CB  . SER B 2 186 ? 28.530  -13.146 19.663  1.00 74.10  ? 186 SER H CB  1 
ATOM   2957 O  OG  . SER B 2 186 ? 29.134  -14.134 20.470  1.00 82.66  ? 186 SER H OG  1 
ATOM   2958 N  N   . SER B 2 187 ? 30.159  -13.414 16.969  1.00 81.53  ? 187 SER H N   1 
ATOM   2959 C  CA  . SER B 2 187 ? 31.433  -13.752 16.340  1.00 82.56  ? 187 SER H CA  1 
ATOM   2960 C  C   . SER B 2 187 ? 31.290  -14.715 15.157  1.00 88.91  ? 187 SER H C   1 
ATOM   2961 O  O   . SER B 2 187 ? 32.214  -15.461 14.833  1.00 90.67  ? 187 SER H O   1 
ATOM   2962 C  CB  . SER B 2 187 ? 32.408  -14.313 17.381  1.00 86.54  ? 187 SER H CB  1 
ATOM   2963 O  OG  . SER B 2 187 ? 33.667  -14.601 16.808  1.00 87.91  ? 187 SER H OG  1 
ATOM   2964 N  N   . SER B 2 188 ? 30.134  -14.685 14.502  1.00 86.92  ? 188 SER H N   1 
ATOM   2965 C  CA  . SER B 2 188 ? 29.848  -15.619 13.413  1.00 76.87  ? 188 SER H CA  1 
ATOM   2966 C  C   . SER B 2 188 ? 29.549  -14.910 12.086  1.00 80.69  ? 188 SER H C   1 
ATOM   2967 O  O   . SER B 2 188 ? 30.455  -14.429 11.394  1.00 75.44  ? 188 SER H O   1 
ATOM   2968 C  CB  . SER B 2 188 ? 28.671  -16.538 13.781  1.00 74.97  ? 188 SER H CB  1 
ATOM   2969 O  OG  . SER B 2 188 ? 29.029  -17.569 14.694  1.00 75.19  ? 188 SER H OG  1 
ATOM   2970 N  N   . GLN B 2 189 ? 28.262  -14.861 11.751  1.00 76.68  ? 189 GLN H N   1 
ATOM   2971 C  CA  . GLN B 2 189 ? 27.798  -14.280 10.503  1.00 76.02  ? 189 GLN H CA  1 
ATOM   2972 C  C   . GLN B 2 189 ? 28.304  -12.863 10.349  1.00 77.91  ? 189 GLN H C   1 
ATOM   2973 O  O   . GLN B 2 189 ? 28.105  -12.033 11.239  1.00 81.81  ? 189 GLN H O   1 
ATOM   2974 C  CB  . GLN B 2 189 ? 26.264  -14.253 10.455  1.00 61.58  ? 189 GLN H CB  1 
ATOM   2975 C  CG  . GLN B 2 189 ? 25.584  -15.597 10.255  1.00 68.00  ? 189 GLN H CG  1 
ATOM   2976 C  CD  . GLN B 2 189 ? 24.813  -16.049 11.483  1.00 67.60  ? 189 GLN H CD  1 
ATOM   2977 O  OE1 . GLN B 2 189 ? 23.593  -16.235 11.436  1.00 66.11  ? 189 GLN H OE1 1 
ATOM   2978 N  NE2 . GLN B 2 189 ? 25.522  -16.231 12.593  1.00 70.08  ? 189 GLN H NE2 1 
ATOM   2979 N  N   . PRO B 2 190 ? 29.017  -12.595 9.247   1.00 80.89  ? 190 PRO H N   1 
ATOM   2980 C  CA  . PRO B 2 190 ? 28.979  -11.222 8.758   1.00 65.93  ? 190 PRO H CA  1 
ATOM   2981 C  C   . PRO B 2 190 ? 27.616  -11.109 8.106   1.00 55.20  ? 190 PRO H C   1 
ATOM   2982 O  O   . PRO B 2 190 ? 27.294  -11.899 7.218   1.00 54.52  ? 190 PRO H O   1 
ATOM   2983 C  CB  . PRO B 2 190 ? 30.080  -11.193 7.698   1.00 69.54  ? 190 PRO H CB  1 
ATOM   2984 C  CG  . PRO B 2 190 ? 30.962  -12.350 8.031   1.00 71.73  ? 190 PRO H CG  1 
ATOM   2985 C  CD  . PRO B 2 190 ? 30.026  -13.398 8.543   1.00 82.12  ? 190 PRO H CD  1 
ATOM   2986 N  N   . VAL B 2 191 ? 26.809  -10.172 8.579   1.00 44.50  ? 191 VAL H N   1 
ATOM   2987 C  CA  . VAL B 2 191 ? 25.452  -10.014 8.088   1.00 41.25  ? 191 VAL H CA  1 
ATOM   2988 C  C   . VAL B 2 191 ? 25.361  -8.757  7.243   1.00 33.37  ? 191 VAL H C   1 
ATOM   2989 O  O   . VAL B 2 191 ? 26.117  -7.810  7.450   1.00 34.57  ? 191 VAL H O   1 
ATOM   2990 C  CB  . VAL B 2 191 ? 24.461  -9.921  9.255   1.00 38.34  ? 191 VAL H CB  1 
ATOM   2991 C  CG1 . VAL B 2 191 ? 24.415  -11.229 10.001  1.00 49.46  ? 191 VAL H CG1 1 
ATOM   2992 C  CG2 . VAL B 2 191 ? 24.864  -8.797  10.188  1.00 35.12  ? 191 VAL H CG2 1 
ATOM   2993 N  N   . THR B 2 192 ? 24.423  -8.746  6.300   1.00 33.76  ? 192 THR H N   1 
ATOM   2994 C  CA  . THR B 2 192 ? 24.292  -7.627  5.371   1.00 30.68  ? 192 THR H CA  1 
ATOM   2995 C  C   . THR B 2 192 ? 22.863  -7.125  5.335   1.00 28.74  ? 192 THR H C   1 
ATOM   2996 O  O   . THR B 2 192 ? 21.938  -7.905  5.104   1.00 30.69  ? 192 THR H O   1 
ATOM   2997 C  CB  . THR B 2 192 ? 24.697  -8.057  3.942   1.00 32.92  ? 192 THR H CB  1 
ATOM   2998 O  OG1 . THR B 2 192 ? 26.050  -8.514  3.954   1.00 31.13  ? 192 THR H OG1 1 
ATOM   2999 C  CG2 . THR B 2 192 ? 24.576  -6.907  2.953   1.00 30.24  ? 192 THR H CG2 1 
ATOM   3000 N  N   . CYS B 2 193 ? 22.671  -5.826  5.560   1.00 29.99  ? 193 CYS H N   1 
ATOM   3001 C  CA  . CYS B 2 193 ? 21.349  -5.249  5.364   1.00 27.69  ? 193 CYS H CA  1 
ATOM   3002 C  C   . CYS B 2 193 ? 21.191  -4.771  3.925   1.00 24.41  ? 193 CYS H C   1 
ATOM   3003 O  O   . CYS B 2 193 ? 22.104  -4.188  3.355   1.00 28.27  ? 193 CYS H O   1 
ATOM   3004 C  CB  . CYS B 2 193 ? 21.072  -4.104  6.356   1.00 27.03  ? 193 CYS H CB  1 
ATOM   3005 S  SG  . CYS B 2 193 ? 22.040  -2.606  6.123   1.00 27.10  ? 193 CYS H SG  1 
ATOM   3006 N  N   . ASN B 2 194 ? 20.030  -5.036  3.341   1.00 23.88  ? 194 ASN H N   1 
ATOM   3007 C  CA  . ASN B 2 194 ? 19.715  -4.573  2.000   1.00 29.06  ? 194 ASN H CA  1 
ATOM   3008 C  C   . ASN B 2 194 ? 18.621  -3.518  2.095   1.00 28.05  ? 194 ASN H C   1 
ATOM   3009 O  O   . ASN B 2 194 ? 17.512  -3.824  2.512   1.00 25.34  ? 194 ASN H O   1 
ATOM   3010 C  CB  . ASN B 2 194 ? 19.220  -5.734  1.132   1.00 28.70  ? 194 ASN H CB  1 
ATOM   3011 C  CG  . ASN B 2 194 ? 19.862  -7.064  1.507   1.00 33.49  ? 194 ASN H CG  1 
ATOM   3012 O  OD1 . ASN B 2 194 ? 19.198  -7.967  2.018   1.00 30.67  ? 194 ASN H OD1 1 
ATOM   3013 N  ND2 . ASN B 2 194 ? 21.158  -7.186  1.248   1.00 31.77  ? 194 ASN H ND2 1 
ATOM   3014 N  N   . VAL B 2 195 ? 18.938  -2.282  1.714   1.00 27.70  ? 195 VAL H N   1 
ATOM   3015 C  CA  . VAL B 2 195 ? 18.006  -1.184  1.878   1.00 23.85  ? 195 VAL H CA  1 
ATOM   3016 C  C   . VAL B 2 195 ? 17.580  -0.706  0.506   1.00 27.80  ? 195 VAL H C   1 
ATOM   3017 O  O   . VAL B 2 195 ? 18.406  -0.241  -0.271  1.00 27.28  ? 195 VAL H O   1 
ATOM   3018 C  CB  . VAL B 2 195 ? 18.660  -0.009  2.636   1.00 27.04  ? 195 VAL H CB  1 
ATOM   3019 C  CG1 . VAL B 2 195 ? 17.668  1.140   2.792   1.00 22.76  ? 195 VAL H CG1 1 
ATOM   3020 C  CG2 . VAL B 2 195 ? 19.191  -0.469  3.998   1.00 23.04  ? 195 VAL H CG2 1 
ATOM   3021 N  N   . ALA B 2 196 ? 16.293  -0.810  0.209   1.00 24.70  ? 196 ALA H N   1 
ATOM   3022 C  CA  . ALA B 2 196 ? 15.778  -0.350  -1.068  1.00 23.39  ? 196 ALA H CA  1 
ATOM   3023 C  C   . ALA B 2 196 ? 14.890  0.867   -0.869  1.00 29.74  ? 196 ALA H C   1 
ATOM   3024 O  O   . ALA B 2 196 ? 14.108  0.911   0.081   1.00 28.25  ? 196 ALA H O   1 
ATOM   3025 C  CB  . ALA B 2 196 ? 14.999  -1.461  -1.744  1.00 32.76  ? 196 ALA H CB  1 
ATOM   3026 N  N   . HIS B 2 197 ? 15.011  1.830   -1.783  1.00 22.59  ? 197 HIS H N   1 
ATOM   3027 C  CA  . HIS B 2 197 ? 14.218  3.059   -1.797  1.00 22.45  ? 197 HIS H CA  1 
ATOM   3028 C  C   . HIS B 2 197 ? 13.641  3.270   -3.197  1.00 27.84  ? 197 HIS H C   1 
ATOM   3029 O  O   . HIS B 2 197 ? 14.272  3.894   -4.045  1.00 24.53  ? 197 HIS H O   1 
ATOM   3030 C  CB  . HIS B 2 197 ? 15.087  4.264   -1.413  1.00 20.78  ? 197 HIS H CB  1 
ATOM   3031 C  CG  . HIS B 2 197 ? 14.322  5.545   -1.257  1.00 23.55  ? 197 HIS H CG  1 
ATOM   3032 N  ND1 . HIS B 2 197 ? 14.647  6.692   -1.948  1.00 20.26  ? 197 HIS H ND1 1 
ATOM   3033 C  CD2 . HIS B 2 197 ? 13.254  5.857   -0.483  1.00 20.39  ? 197 HIS H CD2 1 
ATOM   3034 C  CE1 . HIS B 2 197 ? 13.808  7.660   -1.608  1.00 23.69  ? 197 HIS H CE1 1 
ATOM   3035 N  NE2 . HIS B 2 197 ? 12.962  7.183   -0.711  1.00 21.50  ? 197 HIS H NE2 1 
ATOM   3036 N  N   . PRO B 2 198 ? 12.438  2.738   -3.444  1.00 29.97  ? 198 PRO H N   1 
ATOM   3037 C  CA  . PRO B 2 198 ? 11.805  2.744   -4.770  1.00 27.25  ? 198 PRO H CA  1 
ATOM   3038 C  C   . PRO B 2 198 ? 11.724  4.126   -5.428  1.00 26.58  ? 198 PRO H C   1 
ATOM   3039 O  O   . PRO B 2 198 ? 11.912  4.226   -6.634  1.00 31.08  ? 198 PRO H O   1 
ATOM   3040 C  CB  . PRO B 2 198 ? 10.407  2.199   -4.485  1.00 30.99  ? 198 PRO H CB  1 
ATOM   3041 C  CG  . PRO B 2 198 ? 10.582  1.342   -3.275  1.00 29.62  ? 198 PRO H CG  1 
ATOM   3042 C  CD  . PRO B 2 198 ? 11.606  2.050   -2.444  1.00 27.28  ? 198 PRO H CD  1 
ATOM   3043 N  N   . ALA B 2 199 ? 11.471  5.177   -4.655  1.00 28.70  ? 199 ALA H N   1 
ATOM   3044 C  CA  . ALA B 2 199 ? 11.346  6.517   -5.228  1.00 23.33  ? 199 ALA H CA  1 
ATOM   3045 C  C   . ALA B 2 199 ? 12.611  7.034   -5.918  1.00 30.56  ? 199 ALA H C   1 
ATOM   3046 O  O   . ALA B 2 199 ? 12.535  7.886   -6.798  1.00 31.01  ? 199 ALA H O   1 
ATOM   3047 C  CB  . ALA B 2 199 ? 10.881  7.514   -4.169  1.00 30.98  ? 199 ALA H CB  1 
ATOM   3048 N  N   . THR B 2 200 ? 13.774  6.536   -5.513  1.00 26.01  ? 200 THR H N   1 
ATOM   3049 C  CA  . THR B 2 200 ? 15.021  6.950   -6.160  1.00 22.40  ? 200 THR H CA  1 
ATOM   3050 C  C   . THR B 2 200 ? 15.656  5.815   -6.955  1.00 25.59  ? 200 THR H C   1 
ATOM   3051 O  O   . THR B 2 200 ? 16.755  5.968   -7.475  1.00 31.15  ? 200 THR H O   1 
ATOM   3052 C  CB  . THR B 2 200 ? 16.040  7.482   -5.140  1.00 26.28  ? 200 THR H CB  1 
ATOM   3053 O  OG1 . THR B 2 200 ? 16.292  6.483   -4.142  1.00 21.73  ? 200 THR H OG1 1 
ATOM   3054 C  CG2 . THR B 2 200 ? 15.514  8.746   -4.474  1.00 23.68  ? 200 THR H CG2 1 
ATOM   3055 N  N   . ASN B 2 201 ? 14.956  4.683   -7.034  1.00 27.55  ? 201 ASN H N   1 
ATOM   3056 C  CA  . ASN B 2 201 ? 15.443  3.498   -7.746  1.00 30.16  ? 201 ASN H CA  1 
ATOM   3057 C  C   . ASN B 2 201 ? 16.767  2.968   -7.195  1.00 29.25  ? 201 ASN H C   1 
ATOM   3058 O  O   . ASN B 2 201 ? 17.581  2.407   -7.931  1.00 29.43  ? 201 ASN H O   1 
ATOM   3059 C  CB  . ASN B 2 201 ? 15.559  3.774   -9.255  1.00 32.65  ? 201 ASN H CB  1 
ATOM   3060 C  CG  . ASN B 2 201 ? 14.231  4.189   -9.874  1.00 35.63  ? 201 ASN H CG  1 
ATOM   3061 O  OD1 . ASN B 2 201 ? 13.301  3.387   -9.971  1.00 37.88  ? 201 ASN H OD1 1 
ATOM   3062 N  ND2 . ASN B 2 201 ? 14.137  5.447   -10.286 1.00 36.57  ? 201 ASN H ND2 1 
ATOM   3063 N  N   . THR B 2 202 ? 16.976  3.129   -5.895  1.00 27.44  ? 202 THR H N   1 
ATOM   3064 C  CA  . THR B 2 202 ? 18.244  2.733   -5.302  1.00 25.51  ? 202 THR H CA  1 
ATOM   3065 C  C   . THR B 2 202 ? 18.089  1.520   -4.399  1.00 25.77  ? 202 THR H C   1 
ATOM   3066 O  O   . THR B 2 202 ? 17.035  1.288   -3.797  1.00 25.26  ? 202 THR H O   1 
ATOM   3067 C  CB  . THR B 2 202 ? 18.869  3.882   -4.501  1.00 33.05  ? 202 THR H CB  1 
ATOM   3068 O  OG1 . THR B 2 202 ? 17.973  4.261   -3.458  1.00 27.68  ? 202 THR H OG1 1 
ATOM   3069 C  CG2 . THR B 2 202 ? 19.126  5.099   -5.397  1.00 29.19  ? 202 THR H CG2 1 
ATOM   3070 N  N   . LYS B 2 203 ? 19.150  0.736   -4.329  1.00 25.07  ? 203 LYS H N   1 
ATOM   3071 C  CA  . LYS B 2 203 ? 19.251  -0.342  -3.361  1.00 24.80  ? 203 LYS H CA  1 
ATOM   3072 C  C   . LYS B 2 203 ? 20.678  -0.368  -2.845  1.00 26.52  ? 203 LYS H C   1 
ATOM   3073 O  O   . LYS B 2 203 ? 21.630  -0.438  -3.632  1.00 30.23  ? 203 LYS H O   1 
ATOM   3074 C  CB  . LYS B 2 203 ? 18.894  -1.679  -4.001  1.00 24.10  ? 203 LYS H CB  1 
ATOM   3075 C  CG  . LYS B 2 203 ? 18.957  -2.844  -3.023  1.00 36.53  ? 203 LYS H CG  1 
ATOM   3076 C  CD  . LYS B 2 203 ? 17.967  -3.922  -3.395  1.00 45.42  ? 203 LYS H CD  1 
ATOM   3077 C  CE  . LYS B 2 203 ? 17.970  -5.046  -2.372  1.00 44.88  ? 203 LYS H CE  1 
ATOM   3078 N  NZ  . LYS B 2 203 ? 16.909  -6.045  -2.676  1.00 44.18  ? 203 LYS H NZ  1 
ATOM   3079 N  N   . VAL B 2 204 ? 20.832  -0.293  -1.530  1.00 19.96  ? 204 VAL H N   1 
ATOM   3080 C  CA  . VAL B 2 204 ? 22.164  -0.284  -0.921  1.00 24.80  ? 204 VAL H CA  1 
ATOM   3081 C  C   . VAL B 2 204 ? 22.365  -1.499  -0.027  1.00 31.08  ? 204 VAL H C   1 
ATOM   3082 O  O   . VAL B 2 204 ? 21.460  -1.875  0.717   1.00 24.80  ? 204 VAL H O   1 
ATOM   3083 C  CB  . VAL B 2 204 ? 22.391  1.013   -0.095  1.00 29.51  ? 204 VAL H CB  1 
ATOM   3084 C  CG1 . VAL B 2 204 ? 23.639  0.908   0.776   1.00 32.13  ? 204 VAL H CG1 1 
ATOM   3085 C  CG2 . VAL B 2 204 ? 22.480  2.228   -1.025  1.00 32.32  ? 204 VAL H CG2 1 
ATOM   3086 N  N   . ASP B 2 205 ? 23.540  -2.120  -0.117  1.00 29.17  ? 205 ASP H N   1 
ATOM   3087 C  CA  . ASP B 2 205 ? 23.919  -3.187  0.809   1.00 30.81  ? 205 ASP H CA  1 
ATOM   3088 C  C   . ASP B 2 205 ? 24.967  -2.678  1.787   1.00 32.60  ? 205 ASP H C   1 
ATOM   3089 O  O   . ASP B 2 205 ? 25.856  -1.914  1.425   1.00 38.49  ? 205 ASP H O   1 
ATOM   3090 C  CB  . ASP B 2 205 ? 24.445  -4.424  0.068   1.00 32.23  ? 205 ASP H CB  1 
ATOM   3091 C  CG  . ASP B 2 205 ? 23.385  -5.082  -0.780  1.00 38.24  ? 205 ASP H CG  1 
ATOM   3092 O  OD1 . ASP B 2 205 ? 23.672  -5.421  -1.949  1.00 53.34  ? 205 ASP H OD1 1 
ATOM   3093 O  OD2 . ASP B 2 205 ? 22.251  -5.248  -0.287  1.00 41.00  ? 205 ASP H OD2 1 
ATOM   3094 N  N   . LYS B 2 206 ? 24.856  -3.091  3.040   1.00 28.37  ? 206 LYS H N   1 
ATOM   3095 C  CA  . LYS B 2 206 ? 25.854  -2.729  4.034   1.00 25.49  ? 206 LYS H CA  1 
ATOM   3096 C  C   . LYS B 2 206 ? 26.171  -3.942  4.894   1.00 35.09  ? 206 LYS H C   1 
ATOM   3097 O  O   . LYS B 2 206 ? 25.314  -4.440  5.623   1.00 31.15  ? 206 LYS H O   1 
ATOM   3098 C  CB  . LYS B 2 206 ? 25.362  -1.574  4.909   1.00 27.56  ? 206 LYS H CB  1 
ATOM   3099 C  CG  . LYS B 2 206 ? 26.445  -0.951  5.763   1.00 33.22  ? 206 LYS H CG  1 
ATOM   3100 C  CD  . LYS B 2 206 ? 27.423  -0.178  4.899   1.00 39.09  ? 206 LYS H CD  1 
ATOM   3101 C  CE  . LYS B 2 206 ? 26.681  0.859   4.070   1.00 35.94  ? 206 LYS H CE  1 
ATOM   3102 N  NZ  . LYS B 2 206 ? 27.577  1.586   3.122   1.00 51.92  ? 206 LYS H NZ  1 
ATOM   3103 N  N   . THR B 2 207 ? 27.405  -4.422  4.803   1.00 33.77  ? 207 THR H N   1 
ATOM   3104 C  CA  . THR B 2 207 ? 27.810  -5.584  5.580   1.00 33.96  ? 207 THR H CA  1 
ATOM   3105 C  C   . THR B 2 207 ? 28.314  -5.135  6.936   1.00 33.62  ? 207 THR H C   1 
ATOM   3106 O  O   . THR B 2 207 ? 29.177  -4.263  7.028   1.00 34.98  ? 207 THR H O   1 
ATOM   3107 C  CB  . THR B 2 207 ? 28.872  -6.419  4.834   1.00 36.06  ? 207 THR H CB  1 
ATOM   3108 O  OG1 . THR B 2 207 ? 28.290  -6.921  3.626   1.00 35.20  ? 207 THR H OG1 1 
ATOM   3109 C  CG2 . THR B 2 207 ? 29.323  -7.596  5.686   1.00 37.29  ? 207 THR H CG2 1 
ATOM   3110 N  N   . VAL B 2 208 ? 27.749  -5.706  7.995   1.00 31.95  ? 208 VAL H N   1 
ATOM   3111 C  CA  . VAL B 2 208 ? 28.111  -5.306  9.347   1.00 36.45  ? 208 VAL H CA  1 
ATOM   3112 C  C   . VAL B 2 208 ? 28.827  -6.437  10.072  1.00 45.52  ? 208 VAL H C   1 
ATOM   3113 O  O   . VAL B 2 208 ? 28.344  -7.568  10.126  1.00 41.68  ? 208 VAL H O   1 
ATOM   3114 C  CB  . VAL B 2 208 ? 26.883  -4.908  10.179  1.00 35.04  ? 208 VAL H CB  1 
ATOM   3115 C  CG1 . VAL B 2 208 ? 27.322  -4.153  11.432  1.00 31.87  ? 208 VAL H CG1 1 
ATOM   3116 C  CG2 . VAL B 2 208 ? 25.929  -4.067  9.351   1.00 34.88  ? 208 VAL H CG2 1 
ATOM   3117 N  N   . ALA B 2 209 ? 29.988  -6.125  10.630  1.00 49.65  ? 209 ALA H N   1 
ATOM   3118 C  CA  . ALA B 2 209 ? 30.762  -7.115  11.367  1.00 61.92  ? 209 ALA H CA  1 
ATOM   3119 C  C   . ALA B 2 209 ? 30.724  -6.739  12.834  1.00 61.50  ? 209 ALA H C   1 
ATOM   3120 O  O   . ALA B 2 209 ? 30.732  -5.552  13.159  1.00 63.37  ? 209 ALA H O   1 
ATOM   3121 C  CB  . ALA B 2 209 ? 32.205  -7.161  10.865  1.00 69.83  ? 209 ALA H CB  1 
ATOM   3122 N  N   . PRO B 2 210 ? 30.674  -7.741  13.728  1.00 57.95  ? 210 PRO H N   1 
ATOM   3123 C  CA  . PRO B 2 210 ? 30.725  -7.464  15.171  1.00 67.01  ? 210 PRO H CA  1 
ATOM   3124 C  C   . PRO B 2 210 ? 31.997  -6.667  15.462  1.00 75.38  ? 210 PRO H C   1 
ATOM   3125 O  O   . PRO B 2 210 ? 32.938  -6.801  14.692  1.00 79.93  ? 210 PRO H O   1 
ATOM   3126 C  CB  . PRO B 2 210 ? 30.850  -8.864  15.782  1.00 67.03  ? 210 PRO H CB  1 
ATOM   3127 C  CG  . PRO B 2 210 ? 31.438  -9.712  14.683  1.00 67.05  ? 210 PRO H CG  1 
ATOM   3128 C  CD  . PRO B 2 210 ? 30.812  -9.180  13.435  1.00 64.00  ? 210 PRO H CD  1 
ATOM   3129 N  N   . SER B 2 211 ? 32.089  -5.868  16.518  1.00 79.07  ? 211 SER H N   1 
ATOM   3130 C  CA  . SER B 2 211 ? 33.366  -5.167  16.717  1.00 80.67  ? 211 SER H CA  1 
ATOM   3131 C  C   . SER B 2 211 ? 34.420  -5.994  17.469  1.00 83.20  ? 211 SER H C   1 
ATOM   3132 O  O   . SER B 2 211 ? 34.324  -6.180  18.682  1.00 87.53  ? 211 SER H O   1 
ATOM   3133 C  CB  . SER B 2 211 ? 33.175  -3.802  17.386  1.00 80.31  ? 211 SER H CB  1 
ATOM   3134 O  OG  . SER B 2 211 ? 34.409  -3.094  17.426  1.00 77.31  ? 211 SER H OG  1 
ATOM   3135 N  N   . THR B 2 212 ? 35.423  -6.490  16.743  1.00 84.46  ? 212 THR H N   1 
ATOM   3136 C  CA  . THR B 2 212 ? 36.569  -7.158  17.366  1.00 78.18  ? 212 THR H CA  1 
ATOM   3137 C  C   . THR B 2 212 ? 37.542  -6.119  17.915  1.00 80.52  ? 212 THR H C   1 
ATOM   3138 O  O   . THR B 2 212 ? 37.244  -4.923  17.891  1.00 85.45  ? 212 THR H O   1 
ATOM   3139 C  CB  . THR B 2 212 ? 37.325  -8.070  16.375  1.00 75.43  ? 212 THR H CB  1 
ATOM   3140 O  OG1 . THR B 2 212 ? 37.531  -7.373  15.140  1.00 70.23  ? 212 THR H OG1 1 
ATOM   3141 C  CG2 . THR B 2 212 ? 36.543  -9.348  16.108  1.00 80.60  ? 212 THR H CG2 1 
ATOM   3142 N  N   . CYS B 2 213 ? 38.698  -6.581  18.396  1.00 74.80  ? 213 CYS H N   1 
ATOM   3143 C  CA  . CYS B 2 213 ? 39.741  -5.709  18.950  1.00 55.51  ? 213 CYS H CA  1 
ATOM   3144 C  C   . CYS B 2 213 ? 41.012  -6.489  19.315  1.00 59.57  ? 213 CYS H C   1 
ATOM   3145 O  O   . CYS B 2 213 ? 41.345  -7.509  18.704  1.00 61.91  ? 213 CYS H O   1 
ATOM   3146 C  CB  . CYS B 2 213 ? 39.237  -4.956  20.192  1.00 72.59  ? 213 CYS H CB  1 
ATOM   3147 S  SG  . CYS B 2 213 ? 38.732  -3.224  19.924  1.00 94.25  ? 213 CYS H SG  1 
ATOM   3148 N  N   . THR C 3 3   ? -30.846 -3.444  -9.536  1.00 54.36  ? 303 THR P N   1 
ATOM   3149 C  CA  . THR C 3 3   ? -30.360 -2.163  -9.026  1.00 55.19  ? 303 THR P CA  1 
ATOM   3150 C  C   . THR C 3 3   ? -29.696 -2.316  -7.652  1.00 49.16  ? 303 THR P C   1 
ATOM   3151 O  O   . THR C 3 3   ? -30.122 -3.128  -6.824  1.00 44.57  ? 303 THR P O   1 
ATOM   3152 C  CB  . THR C 3 3   ? -31.490 -1.107  -8.931  1.00 54.61  ? 303 THR P CB  1 
ATOM   3153 O  OG1 . THR C 3 3   ? -32.314 -1.375  -7.787  1.00 57.65  ? 303 THR P OG1 1 
ATOM   3154 C  CG2 . THR C 3 3   ? -32.349 -1.117  -10.190 1.00 54.06  ? 303 THR P CG2 1 
ATOM   3155 N  N   . ARG C 3 4   ? -28.650 -1.528  -7.428  1.00 42.03  ? 304 ARG P N   1 
ATOM   3156 C  CA  . ARG C 3 4   ? -27.905 -1.540  -6.172  1.00 38.99  ? 304 ARG P CA  1 
ATOM   3157 C  C   . ARG C 3 4   ? -28.691 -0.857  -5.057  1.00 30.91  ? 304 ARG P C   1 
ATOM   3158 O  O   . ARG C 3 4   ? -29.163 0.268   -5.220  1.00 35.01  ? 304 ARG P O   1 
ATOM   3159 C  CB  . ARG C 3 4   ? -26.566 -0.815  -6.347  1.00 30.91  ? 304 ARG P CB  1 
ATOM   3160 C  CG  . ARG C 3 4   ? -25.819 -0.562  -5.028  1.00 30.95  ? 304 ARG P CG  1 
ATOM   3161 C  CD  . ARG C 3 4   ? -24.682 0.470   -5.189  1.00 22.55  ? 304 ARG P CD  1 
ATOM   3162 N  NE  . ARG C 3 4   ? -23.563 -0.048  -5.973  1.00 19.41  ? 304 ARG P NE  1 
ATOM   3163 C  CZ  . ARG C 3 4   ? -22.567 -0.772  -5.468  1.00 22.12  ? 304 ARG P CZ  1 
ATOM   3164 N  NH1 . ARG C 3 4   ? -22.557 -1.072  -4.172  1.00 23.65  ? 304 ARG P NH1 1 
ATOM   3165 N  NH2 . ARG C 3 4   ? -21.580 -1.195  -6.253  1.00 19.82  ? 304 ARG P NH2 1 
ATOM   3166 N  N   . LYS C 3 5   ? -28.797 -1.524  -3.914  1.00 29.28  ? 305 LYS P N   1 
ATOM   3167 C  CA  . LYS C 3 5   ? -29.473 -0.950  -2.754  1.00 26.91  ? 305 LYS P CA  1 
ATOM   3168 C  C   . LYS C 3 5   ? -28.489 -0.342  -1.755  1.00 23.46  ? 305 LYS P C   1 
ATOM   3169 O  O   . LYS C 3 5   ? -28.758 0.724   -1.177  1.00 23.41  ? 305 LYS P O   1 
ATOM   3170 C  CB  . LYS C 3 5   ? -30.323 -2.024  -2.061  1.00 32.70  ? 305 LYS P CB  1 
ATOM   3171 C  CG  . LYS C 3 5   ? -31.290 -2.736  -3.002  1.00 41.18  ? 305 LYS P CG  1 
ATOM   3172 C  CD  . LYS C 3 5   ? -32.281 -1.748  -3.612  1.00 41.65  ? 305 LYS P CD  1 
ATOM   3173 C  CE  . LYS C 3 5   ? -33.009 -2.362  -4.802  1.00 59.71  ? 305 LYS P CE  1 
ATOM   3174 N  NZ  . LYS C 3 5   ? -33.548 -3.714  -4.495  1.00 69.36  ? 305 LYS P NZ  1 
ATOM   3175 N  N   . SER C 3 6   ? -27.360 -1.024  -1.547  1.00 22.14  ? 306 SER P N   1 
ATOM   3176 C  CA  . SER C 3 6   ? -26.399 -0.650  -0.509  1.00 22.74  ? 306 SER P CA  1 
ATOM   3177 C  C   . SER C 3 6   ? -24.981 -1.079  -0.910  1.00 27.04  ? 306 SER P C   1 
ATOM   3178 O  O   . SER C 3 6   ? -24.661 -1.152  -2.094  1.00 27.86  ? 306 SER P O   1 
ATOM   3179 C  CB  . SER C 3 6   ? -26.795 -1.294  0.834   1.00 22.37  ? 306 SER P CB  1 
ATOM   3180 O  OG  . SER C 3 6   ? -26.055 -0.764  1.939   1.00 22.48  ? 306 SER P OG  1 
ATOM   3181 N  N   . ILE C 3 7   ? -24.119 -1.342  0.068   1.00 17.16  ? 307 ILE P N   1 
ATOM   3182 C  CA  . ILE C 3 7   ? -22.887 -2.079  -0.220  1.00 21.58  ? 307 ILE P CA  1 
ATOM   3183 C  C   . ILE C 3 7   ? -23.056 -3.516  0.274   1.00 19.14  ? 307 ILE P C   1 
ATOM   3184 O  O   . ILE C 3 7   ? -23.775 -3.768  1.250   1.00 20.15  ? 307 ILE P O   1 
ATOM   3185 C  CB  . ILE C 3 7   ? -21.638 -1.468  0.459   1.00 17.78  ? 307 ILE P CB  1 
ATOM   3186 C  CG1 . ILE C 3 7   ? -21.885 -1.270  1.962   1.00 16.76  ? 307 ILE P CG1 1 
ATOM   3187 C  CG2 . ILE C 3 7   ? -21.219 -0.178  -0.225  1.00 23.98  ? 307 ILE P CG2 1 
ATOM   3188 C  CD1 . ILE C 3 7   ? -20.618 -1.070  2.756   1.00 18.05  ? 307 ILE P CD1 1 
ATOM   3189 N  N   . HIS C 3 8   ? -22.420 -4.472  -0.392  1.00 25.49  ? 308 HIS P N   1 
ATOM   3190 C  CA  . HIS C 3 8   ? -22.510 -5.855  0.087   1.00 22.31  ? 308 HIS P CA  1 
ATOM   3191 C  C   . HIS C 3 8   ? -21.288 -6.231  0.924   1.00 24.70  ? 308 HIS P C   1 
ATOM   3192 O  O   . HIS C 3 8   ? -20.158 -6.112  0.448   1.00 19.42  ? 308 HIS P O   1 
ATOM   3193 C  CB  . HIS C 3 8   ? -22.676 -6.838  -1.071  1.00 24.75  ? 308 HIS P CB  1 
ATOM   3194 C  CG  . HIS C 3 8   ? -22.950 -8.241  -0.621  1.00 33.13  ? 308 HIS P CG  1 
ATOM   3195 N  ND1 . HIS C 3 8   ? -24.219 -8.693  -0.324  1.00 41.52  ? 308 HIS P ND1 1 
ATOM   3196 C  CD2 . HIS C 3 8   ? -22.116 -9.274  -0.370  1.00 32.87  ? 308 HIS P CD2 1 
ATOM   3197 C  CE1 . HIS C 3 8   ? -24.157 -9.952  0.069   1.00 39.60  ? 308 HIS P CE1 1 
ATOM   3198 N  NE2 . HIS C 3 8   ? -22.892 -10.333 0.049   1.00 34.27  ? 308 HIS P NE2 1 
ATOM   3199 N  N   . ILE C 3 9   ? -21.523 -6.679  2.159   1.00 21.25  ? 309 ILE P N   1 
ATOM   3200 C  CA  . ILE C 3 9   ? -20.442 -7.059  3.084   1.00 21.10  ? 309 ILE P CA  1 
ATOM   3201 C  C   . ILE C 3 9   ? -20.529 -8.556  3.426   1.00 25.48  ? 309 ILE P C   1 
ATOM   3202 O  O   . ILE C 3 9   ? -21.573 -9.038  3.852   1.00 25.25  ? 309 ILE P O   1 
ATOM   3203 C  CB  . ILE C 3 9   ? -20.503 -6.250  4.422   1.00 23.99  ? 309 ILE P CB  1 
ATOM   3204 C  CG1 . ILE C 3 9   ? -20.520 -4.737  4.172   1.00 18.72  ? 309 ILE P CG1 1 
ATOM   3205 C  CG2 . ILE C 3 9   ? -19.324 -6.616  5.336   1.00 21.78  ? 309 ILE P CG2 1 
ATOM   3206 C  CD1 . ILE C 3 9   ? -20.713 -3.908  5.449   1.00 18.38  ? 309 ILE P CD1 1 
ATOM   3207 N  N   . GLY C 3 10  ? -19.438 -9.282  3.218   1.00 20.40  ? 312 GLY P N   1 
ATOM   3208 C  CA  . GLY C 3 10  ? -19.354 -10.675 3.601   1.00 26.58  ? 312 GLY P CA  1 
ATOM   3209 C  C   . GLY C 3 10  ? -19.734 -11.611 2.466   1.00 32.12  ? 312 GLY P C   1 
ATOM   3210 O  O   . GLY C 3 10  ? -19.940 -11.170 1.334   1.00 28.44  ? 312 GLY P O   1 
ATOM   3211 N  N   . PRO C 3 11  ? -19.860 -12.913 2.773   1.00 40.73  ? 313 PRO P N   1 
ATOM   3212 C  CA  . PRO C 3 11  ? -20.185 -13.963 1.794   1.00 40.63  ? 313 PRO P CA  1 
ATOM   3213 C  C   . PRO C 3 11  ? -21.479 -13.679 1.034   1.00 46.59  ? 313 PRO P C   1 
ATOM   3214 O  O   . PRO C 3 11  ? -22.439 -13.155 1.608   1.00 49.02  ? 313 PRO P O   1 
ATOM   3215 C  CB  . PRO C 3 11  ? -20.362 -15.210 2.664   1.00 51.92  ? 313 PRO P CB  1 
ATOM   3216 C  CG  . PRO C 3 11  ? -19.617 -14.906 3.931   1.00 50.67  ? 313 PRO P CG  1 
ATOM   3217 C  CD  . PRO C 3 11  ? -19.805 -13.439 4.147   1.00 40.97  ? 313 PRO P CD  1 
ATOM   3218 N  N   . GLY C 3 12  ? -21.502 -14.023 -0.249  1.00 54.95  ? 314 GLY P N   1 
ATOM   3219 C  CA  . GLY C 3 12  ? -22.648 -13.730 -1.090  1.00 55.47  ? 314 GLY P CA  1 
ATOM   3220 C  C   . GLY C 3 12  ? -23.664 -14.855 -1.114  1.00 61.64  ? 314 GLY P C   1 
ATOM   3221 O  O   . GLY C 3 12  ? -24.530 -14.894 -1.988  1.00 68.05  ? 314 GLY P O   1 
ATOM   3222 N  N   . GLN D 1 1   ? 6.617   -45.330 36.232  1.00 21.04  ? 2   GLN M N   1 
ATOM   3223 C  CA  . GLN D 1 1   ? 6.552   -44.300 35.219  1.00 24.53  ? 2   GLN M CA  1 
ATOM   3224 C  C   . GLN D 1 1   ? 7.862   -44.378 34.450  1.00 25.23  ? 2   GLN M C   1 
ATOM   3225 O  O   . GLN D 1 1   ? 8.939   -44.365 35.037  1.00 21.02  ? 2   GLN M O   1 
ATOM   3226 C  CB  . GLN D 1 1   ? 6.339   -42.918 35.857  1.00 20.68  ? 2   GLN M CB  1 
ATOM   3227 C  CG  . GLN D 1 1   ? 6.440   -42.900 37.384  1.00 24.88  ? 2   GLN M CG  1 
ATOM   3228 C  CD  . GLN D 1 1   ? 5.461   -43.825 38.086  1.00 37.50  ? 2   GLN M CD  1 
ATOM   3229 O  OE1 . GLN D 1 1   ? 4.256   -43.575 38.095  1.00 53.83  ? 2   GLN M OE1 1 
ATOM   3230 N  NE2 . GLN D 1 1   ? 5.978   -44.910 38.677  1.00 18.29  ? 2   GLN M NE2 1 
ATOM   3231 N  N   . VAL D 1 2   ? 7.762   -44.526 33.138  1.00 22.66  ? 3   VAL M N   1 
ATOM   3232 C  CA  . VAL D 1 2   ? 8.942   -44.663 32.301  1.00 21.22  ? 3   VAL M CA  1 
ATOM   3233 C  C   . VAL D 1 2   ? 8.878   -43.574 31.237  1.00 20.49  ? 3   VAL M C   1 
ATOM   3234 O  O   . VAL D 1 2   ? 7.841   -43.382 30.603  1.00 20.23  ? 3   VAL M O   1 
ATOM   3235 C  CB  . VAL D 1 2   ? 8.977   -46.054 31.638  1.00 27.11  ? 3   VAL M CB  1 
ATOM   3236 C  CG1 . VAL D 1 2   ? 10.155  -46.174 30.680  1.00 21.90  ? 3   VAL M CG1 1 
ATOM   3237 C  CG2 . VAL D 1 2   ? 9.044   -47.158 32.710  1.00 27.77  ? 3   VAL M CG2 1 
ATOM   3238 N  N   . LEU D 1 3   ? 9.973   -42.841 31.068  1.00 22.77  ? 4   LEU M N   1 
ATOM   3239 C  CA  . LEU D 1 3   ? 10.029  -41.728 30.117  1.00 18.07  ? 4   LEU M CA  1 
ATOM   3240 C  C   . LEU D 1 3   ? 11.031  -42.094 29.030  1.00 24.03  ? 4   LEU M C   1 
ATOM   3241 O  O   . LEU D 1 3   ? 12.229  -42.133 29.295  1.00 17.58  ? 4   LEU M O   1 
ATOM   3242 C  CB  . LEU D 1 3   ? 10.507  -40.446 30.818  1.00 19.82  ? 4   LEU M CB  1 
ATOM   3243 C  CG  . LEU D 1 3   ? 9.696   -39.155 30.829  1.00 27.13  ? 4   LEU M CG  1 
ATOM   3244 C  CD1 . LEU D 1 3   ? 10.553  -37.931 31.164  1.00 20.88  ? 4   LEU M CD1 1 
ATOM   3245 C  CD2 . LEU D 1 3   ? 8.911   -38.952 29.536  1.00 22.12  ? 4   LEU M CD2 1 
ATOM   3246 N  N   . THR D 1 4   ? 10.550  -42.360 27.814  1.00 20.80  ? 5   THR M N   1 
ATOM   3247 C  CA  . THR D 1 4   ? 11.412  -42.891 26.758  1.00 16.94  ? 5   THR M CA  1 
ATOM   3248 C  C   . THR D 1 4   ? 11.895  -41.752 25.867  1.00 20.02  ? 5   THR M C   1 
ATOM   3249 O  O   . THR D 1 4   ? 11.085  -41.087 25.211  1.00 18.46  ? 5   THR M O   1 
ATOM   3250 C  CB  . THR D 1 4   ? 10.663  -43.935 25.903  1.00 22.29  ? 5   THR M CB  1 
ATOM   3251 O  OG1 . THR D 1 4   ? 10.199  -45.015 26.740  1.00 22.10  ? 5   THR M OG1 1 
ATOM   3252 C  CG2 . THR D 1 4   ? 11.573  -44.492 24.812  1.00 24.53  ? 5   THR M CG2 1 
ATOM   3253 N  N   . GLN D 1 5   ? 13.205  -41.511 25.858  1.00 17.06  ? 6   GLN M N   1 
ATOM   3254 C  CA  . GLN D 1 5   ? 13.769  -40.380 25.109  1.00 21.67  ? 6   GLN M CA  1 
ATOM   3255 C  C   . GLN D 1 5   ? 14.448  -40.826 23.808  1.00 23.74  ? 6   GLN M C   1 
ATOM   3256 O  O   . GLN D 1 5   ? 15.250  -41.766 23.806  1.00 20.85  ? 6   GLN M O   1 
ATOM   3257 C  CB  . GLN D 1 5   ? 14.755  -39.591 25.985  1.00 17.49  ? 6   GLN M CB  1 
ATOM   3258 C  CG  . GLN D 1 5   ? 15.352  -38.369 25.282  1.00 20.92  ? 6   GLN M CG  1 
ATOM   3259 C  CD  . GLN D 1 5   ? 16.174  -37.480 26.214  1.00 20.27  ? 6   GLN M CD  1 
ATOM   3260 O  OE1 . GLN D 1 5   ? 16.077  -37.580 27.441  1.00 18.37  ? 6   GLN M OE1 1 
ATOM   3261 N  NE2 . GLN D 1 5   ? 16.985  -36.606 25.629  1.00 20.02  ? 6   GLN M NE2 1 
ATOM   3262 N  N   . THR D 1 6   ? 14.111  -40.169 22.700  1.00 17.39  ? 7   THR M N   1 
ATOM   3263 C  CA  . THR D 1 6   ? 14.685  -40.527 21.401  1.00 21.28  ? 7   THR M CA  1 
ATOM   3264 C  C   . THR D 1 6   ? 15.026  -39.261 20.605  1.00 20.57  ? 7   THR M C   1 
ATOM   3265 O  O   . THR D 1 6   ? 14.354  -38.244 20.744  1.00 21.59  ? 7   THR M O   1 
ATOM   3266 C  CB  . THR D 1 6   ? 13.695  -41.358 20.552  1.00 20.67  ? 7   THR M CB  1 
ATOM   3267 O  OG1 . THR D 1 6   ? 12.511  -40.582 20.341  1.00 24.76  ? 7   THR M OG1 1 
ATOM   3268 C  CG2 . THR D 1 6   ? 13.323  -42.679 21.229  1.00 23.02  ? 7   THR M CG2 1 
ATOM   3269 N  N   . PRO D 1 7   ? 16.071  -39.312 19.767  1.00 19.68  ? 8   PRO M N   1 
ATOM   3270 C  CA  . PRO D 1 7   ? 16.985  -40.436 19.547  1.00 16.67  ? 8   PRO M CA  1 
ATOM   3271 C  C   . PRO D 1 7   ? 18.038  -40.455 20.644  1.00 20.68  ? 8   PRO M C   1 
ATOM   3272 O  O   . PRO D 1 7   ? 18.161  -39.487 21.386  1.00 17.30  ? 8   PRO M O   1 
ATOM   3273 C  CB  . PRO D 1 7   ? 17.655  -40.065 18.227  1.00 19.85  ? 8   PRO M CB  1 
ATOM   3274 C  CG  . PRO D 1 7   ? 17.771  -38.537 18.323  1.00 19.21  ? 8   PRO M CG  1 
ATOM   3275 C  CD  . PRO D 1 7   ? 16.479  -38.111 19.007  1.00 16.78  ? 8   PRO M CD  1 
ATOM   3276 N  N   . SER D 1 8   ? 18.810  -41.530 20.730  1.00 17.74  ? 9   SER M N   1 
ATOM   3277 C  CA  . SER D 1 8   ? 19.871  -41.602 21.716  1.00 21.61  ? 9   SER M CA  1 
ATOM   3278 C  C   . SER D 1 8   ? 21.067  -40.737 21.318  1.00 19.84  ? 9   SER M C   1 
ATOM   3279 O  O   . SER D 1 8   ? 21.853  -40.313 22.173  1.00 17.45  ? 9   SER M O   1 
ATOM   3280 C  CB  . SER D 1 8   ? 20.308  -43.048 21.925  1.00 20.45  ? 9   SER M CB  1 
ATOM   3281 O  OG  . SER D 1 8   ? 21.023  -43.491 20.789  1.00 32.44  ? 9   SER M OG  1 
ATOM   3282 N  N   . SER D 1 9   ? 21.213  -40.475 20.022  1.00 18.04  ? 10  SER M N   1 
ATOM   3283 C  CA  . SER D 1 9   ? 22.242  -39.519 19.562  1.00 19.93  ? 10  SER M CA  1 
ATOM   3284 C  C   . SER D 1 9   ? 21.847  -38.931 18.221  1.00 20.99  ? 10  SER M C   1 
ATOM   3285 O  O   . SER D 1 9   ? 21.046  -39.520 17.495  1.00 17.71  ? 10  SER M O   1 
ATOM   3286 C  CB  . SER D 1 9   ? 23.630  -40.162 19.464  1.00 20.08  ? 10  SER M CB  1 
ATOM   3287 O  OG  . SER D 1 9   ? 23.624  -41.219 18.522  1.00 32.99  ? 10  SER M OG  1 
ATOM   3288 N  N   . VAL D 1 10  ? 22.401  -37.762 17.911  1.00 17.86  ? 11  VAL M N   1 
ATOM   3289 C  CA  . VAL D 1 10  ? 22.160  -37.110 16.630  1.00 18.66  ? 11  VAL M CA  1 
ATOM   3290 C  C   . VAL D 1 10  ? 23.342  -36.203 16.321  1.00 18.80  ? 11  VAL M C   1 
ATOM   3291 O  O   . VAL D 1 10  ? 23.931  -35.602 17.224  1.00 19.65  ? 11  VAL M O   1 
ATOM   3292 C  CB  . VAL D 1 10  ? 20.818  -36.311 16.620  1.00 18.67  ? 11  VAL M CB  1 
ATOM   3293 C  CG1 . VAL D 1 10  ? 20.864  -35.132 17.613  1.00 17.99  ? 11  VAL M CG1 1 
ATOM   3294 C  CG2 . VAL D 1 10  ? 20.470  -35.803 15.206  1.00 18.26  ? 11  VAL M CG2 1 
ATOM   3295 N  N   . SER D 1 11  ? 23.704  -36.136 15.045  1.00 16.06  ? 12  SER M N   1 
ATOM   3296 C  CA  . SER D 1 11  ? 24.702  -35.202 14.555  1.00 14.16  ? 12  SER M CA  1 
ATOM   3297 C  C   . SER D 1 11  ? 24.049  -34.170 13.644  1.00 14.06  ? 12  SER M C   1 
ATOM   3298 O  O   . SER D 1 11  ? 23.315  -34.531 12.729  1.00 17.45  ? 12  SER M O   1 
ATOM   3299 C  CB  . SER D 1 11  ? 25.789  -35.962 13.777  1.00 20.88  ? 12  SER M CB  1 
ATOM   3300 O  OG  . SER D 1 11  ? 26.619  -35.056 13.071  1.00 18.96  ? 12  SER M OG  1 
ATOM   3301 N  N   . THR D 1 12  ? 24.316  -32.889 13.882  1.00 15.73  ? 13  THR M N   1 
ATOM   3302 C  CA  . THR D 1 12  ? 23.628  -31.827 13.144  1.00 14.41  ? 13  THR M CA  1 
ATOM   3303 C  C   . THR D 1 12  ? 24.554  -30.642 12.882  1.00 18.51  ? 13  THR M C   1 
ATOM   3304 O  O   . THR D 1 12  ? 25.520  -30.426 13.622  1.00 18.21  ? 13  THR M O   1 
ATOM   3305 C  CB  . THR D 1 12  ? 22.303  -31.409 13.881  1.00 17.76  ? 13  THR M CB  1 
ATOM   3306 O  OG1 . THR D 1 12  ? 21.340  -30.902 12.948  1.00 17.72  ? 13  THR M OG1 1 
ATOM   3307 C  CG2 . THR D 1 12  ? 22.557  -30.379 14.963  1.00 16.74  ? 13  THR M CG2 1 
ATOM   3308 N  N   . ALA D 1 13  ? 24.287  -29.885 11.814  1.00 18.12  ? 14  ALA M N   1 
ATOM   3309 C  CA  . ALA D 1 13  ? 25.207  -28.824 11.391  1.00 17.76  ? 14  ALA M CA  1 
ATOM   3310 C  C   . ALA D 1 13  ? 25.009  -27.538 12.177  1.00 21.70  ? 14  ALA M C   1 
ATOM   3311 O  O   . ALA D 1 13  ? 23.889  -27.246 12.605  1.00 17.09  ? 14  ALA M O   1 
ATOM   3312 C  CB  . ALA D 1 13  ? 25.042  -28.543 9.900   1.00 19.71  ? 14  ALA M CB  1 
ATOM   3313 N  N   . VAL D 1 14  ? 26.085  -26.769 12.364  1.00 17.31  ? 15  VAL M N   1 
ATOM   3314 C  CA  . VAL D 1 14  ? 25.951  -25.389 12.846  1.00 15.61  ? 15  VAL M CA  1 
ATOM   3315 C  C   . VAL D 1 14  ? 24.929  -24.673 11.957  1.00 22.28  ? 15  VAL M C   1 
ATOM   3316 O  O   . VAL D 1 14  ? 24.988  -24.765 10.727  1.00 21.56  ? 15  VAL M O   1 
ATOM   3317 C  CB  . VAL D 1 14  ? 27.286  -24.595 12.770  1.00 29.57  ? 15  VAL M CB  1 
ATOM   3318 C  CG1 . VAL D 1 14  ? 27.040  -23.119 13.090  1.00 26.78  ? 15  VAL M CG1 1 
ATOM   3319 C  CG2 . VAL D 1 14  ? 28.324  -25.180 13.732  1.00 26.82  ? 15  VAL M CG2 1 
ATOM   3320 N  N   . GLY D 1 15  ? 23.979  -23.980 12.574  1.00 25.11  ? 16  GLY M N   1 
ATOM   3321 C  CA  . GLY D 1 15  ? 23.000  -23.225 11.821  1.00 24.10  ? 16  GLY M CA  1 
ATOM   3322 C  C   . GLY D 1 15  ? 21.729  -23.992 11.497  1.00 26.04  ? 16  GLY M C   1 
ATOM   3323 O  O   . GLY D 1 15  ? 20.745  -23.408 11.028  1.00 20.13  ? 16  GLY M O   1 
ATOM   3324 N  N   . SER D 1 16  ? 21.738  -25.300 11.739  1.00 20.30  ? 17  SER M N   1 
ATOM   3325 C  CA  . SER D 1 16  ? 20.517  -26.093 11.564  1.00 16.94  ? 17  SER M CA  1 
ATOM   3326 C  C   . SER D 1 16  ? 19.615  -25.949 12.781  1.00 15.93  ? 17  SER M C   1 
ATOM   3327 O  O   . SER D 1 16  ? 19.974  -25.290 13.760  1.00 20.24  ? 17  SER M O   1 
ATOM   3328 C  CB  . SER D 1 16  ? 20.850  -27.576 11.337  1.00 20.09  ? 17  SER M CB  1 
ATOM   3329 O  OG  . SER D 1 16  ? 21.413  -28.168 12.504  1.00 17.84  ? 17  SER M OG  1 
ATOM   3330 N  N   . ALA D 1 17  ? 18.434  -26.561 12.714  1.00 13.63  ? 18  ALA M N   1 
ATOM   3331 C  CA  . ALA D 1 17  ? 17.621  -26.745 13.895  1.00 17.18  ? 18  ALA M CA  1 
ATOM   3332 C  C   . ALA D 1 17  ? 17.592  -28.254 14.179  1.00 17.45  ? 18  ALA M C   1 
ATOM   3333 O  O   . ALA D 1 17  ? 17.795  -29.064 13.272  1.00 15.93  ? 18  ALA M O   1 
ATOM   3334 C  CB  . ALA D 1 17  ? 16.201  -26.161 13.687  1.00 17.89  ? 18  ALA M CB  1 
ATOM   3335 N  N   . VAL D 1 18  ? 17.387  -28.630 15.440  1.00 18.92  ? 19  VAL M N   1 
ATOM   3336 C  CA  . VAL D 1 18  ? 17.434  -30.036 15.828  1.00 16.12  ? 19  VAL M CA  1 
ATOM   3337 C  C   . VAL D 1 18  ? 16.328  -30.325 16.848  1.00 16.81  ? 19  VAL M C   1 
ATOM   3338 O  O   . VAL D 1 18  ? 16.023  -29.482 17.693  1.00 17.13  ? 19  VAL M O   1 
ATOM   3339 C  CB  . VAL D 1 18  ? 18.854  -30.407 16.387  1.00 17.47  ? 19  VAL M CB  1 
ATOM   3340 C  CG1 . VAL D 1 18  ? 19.161  -29.633 17.685  1.00 17.60  ? 19  VAL M CG1 1 
ATOM   3341 C  CG2 . VAL D 1 18  ? 18.986  -31.911 16.593  1.00 15.73  ? 19  VAL M CG2 1 
ATOM   3342 N  N   . THR D 1 19  ? 15.699  -31.496 16.761  1.00 17.93  ? 20  THR M N   1 
ATOM   3343 C  CA  . THR D 1 19  ? 14.559  -31.812 17.638  1.00 14.97  ? 20  THR M CA  1 
ATOM   3344 C  C   . THR D 1 19  ? 14.725  -33.156 18.363  1.00 17.99  ? 20  THR M C   1 
ATOM   3345 O  O   . THR D 1 19  ? 15.177  -34.129 17.767  1.00 18.51  ? 20  THR M O   1 
ATOM   3346 C  CB  . THR D 1 19  ? 13.217  -31.785 16.850  1.00 18.37  ? 20  THR M CB  1 
ATOM   3347 O  OG1 . THR D 1 19  ? 13.021  -30.481 16.278  1.00 16.32  ? 20  THR M OG1 1 
ATOM   3348 C  CG2 . THR D 1 19  ? 12.021  -32.130 17.766  1.00 17.89  ? 20  THR M CG2 1 
ATOM   3349 N  N   . ILE D 1 20  ? 14.350  -33.188 19.640  1.00 16.34  ? 21  ILE M N   1 
ATOM   3350 C  CA  . ILE D 1 20  ? 14.422  -34.377 20.488  1.00 21.18  ? 21  ILE M CA  1 
ATOM   3351 C  C   . ILE D 1 20  ? 13.020  -34.694 21.004  1.00 20.94  ? 21  ILE M C   1 
ATOM   3352 O  O   . ILE D 1 20  ? 12.223  -33.787 21.192  1.00 18.89  ? 21  ILE M O   1 
ATOM   3353 C  CB  . ILE D 1 20  ? 15.389  -34.136 21.691  1.00 19.51  ? 21  ILE M CB  1 
ATOM   3354 C  CG1 . ILE D 1 20  ? 16.810  -33.912 21.200  1.00 25.76  ? 21  ILE M CG1 1 
ATOM   3355 C  CG2 . ILE D 1 20  ? 15.383  -35.310 22.675  1.00 29.98  ? 21  ILE M CG2 1 
ATOM   3356 C  CD1 . ILE D 1 20  ? 17.752  -33.532 22.332  1.00 33.71  ? 21  ILE M CD1 1 
ATOM   3357 N  N   . ASN D 1 21  ? 12.717  -35.972 21.235  1.00 19.49  ? 22  ASN M N   1 
ATOM   3358 C  CA  . ASN D 1 21  ? 11.368  -36.395 21.621  1.00 19.97  ? 22  ASN M CA  1 
ATOM   3359 C  C   . ASN D 1 21  ? 11.384  -37.104 22.978  1.00 24.65  ? 22  ASN M C   1 
ATOM   3360 O  O   . ASN D 1 21  ? 12.360  -37.761 23.331  1.00 19.32  ? 22  ASN M O   1 
ATOM   3361 C  CB  . ASN D 1 21  ? 10.768  -37.323 20.547  1.00 20.17  ? 22  ASN M CB  1 
ATOM   3362 C  CG  . ASN D 1 21  ? 9.258   -37.581 20.743  1.00 37.31  ? 22  ASN M CG  1 
ATOM   3363 O  OD1 . ASN D 1 21  ? 8.426   -36.756 20.365  1.00 38.80  ? 22  ASN M OD1 1 
ATOM   3364 N  ND2 . ASN D 1 21  ? 8.909   -38.748 21.304  1.00 34.79  ? 22  ASN M ND2 1 
ATOM   3365 N  N   . CYS D 1 22  ? 10.318  -36.946 23.750  1.00 20.27  ? 23  CYS M N   1 
ATOM   3366 C  CA  . CYS D 1 22  ? 10.136  -37.743 24.965  1.00 20.55  ? 23  CYS M CA  1 
ATOM   3367 C  C   . CYS D 1 22  ? 8.692   -38.197 25.072  1.00 24.36  ? 23  CYS M C   1 
ATOM   3368 O  O   . CYS D 1 22  ? 7.766   -37.391 24.965  1.00 25.44  ? 23  CYS M O   1 
ATOM   3369 C  CB  . CYS D 1 22  ? 10.561  -36.994 26.242  1.00 22.52  ? 23  CYS M CB  1 
ATOM   3370 S  SG  . CYS D 1 22  ? 12.343  -37.105 26.612  1.00 31.33  ? 23  CYS M SG  1 
ATOM   3371 N  N   . GLN D 1 23  ? 8.523   -39.497 25.293  1.00 22.11  ? 24  GLN M N   1 
ATOM   3372 C  CA  . GLN D 1 23  ? 7.230   -40.144 25.344  1.00 22.66  ? 24  GLN M CA  1 
ATOM   3373 C  C   . GLN D 1 23  ? 7.089   -40.850 26.702  1.00 23.90  ? 24  GLN M C   1 
ATOM   3374 O  O   . GLN D 1 23  ? 7.961   -41.640 27.092  1.00 22.82  ? 24  GLN M O   1 
ATOM   3375 C  CB  . GLN D 1 23  ? 7.152   -41.179 24.208  1.00 22.90  ? 24  GLN M CB  1 
ATOM   3376 C  CG  . GLN D 1 23  ? 5.922   -42.059 24.261  1.00 36.81  ? 24  GLN M CG  1 
ATOM   3377 C  CD  . GLN D 1 23  ? 4.712   -41.383 23.650  1.00 52.37  ? 24  GLN M CD  1 
ATOM   3378 O  OE1 . GLN D 1 23  ? 4.842   -40.542 22.750  1.00 49.02  ? 24  GLN M OE1 1 
ATOM   3379 N  NE2 . GLN D 1 23  ? 3.524   -41.740 24.137  1.00 56.18  ? 24  GLN M NE2 1 
ATOM   3380 N  N   . SER D 1 24  ? 5.996   -40.568 27.408  1.00 18.82  ? 25  SER M N   1 
ATOM   3381 C  CA  . SER D 1 24  ? 5.801   -41.025 28.783  1.00 18.31  ? 25  SER M CA  1 
ATOM   3382 C  C   . SER D 1 24  ? 4.775   -42.168 28.852  1.00 22.96  ? 25  SER M C   1 
ATOM   3383 O  O   . SER D 1 24  ? 3.796   -42.175 28.107  1.00 20.25  ? 25  SER M O   1 
ATOM   3384 C  CB  . SER D 1 24  ? 5.380   -39.824 29.652  1.00 21.18  ? 25  SER M CB  1 
ATOM   3385 O  OG  . SER D 1 24  ? 5.215   -40.177 31.019  1.00 16.43  ? 25  SER M OG  1 
ATOM   3386 N  N   . SER D 1 25  ? 5.017   -43.144 29.724  1.00 21.14  ? 26  SER M N   1 
ATOM   3387 C  CA  . SER D 1 25  ? 4.098   -44.273 29.921  1.00 26.13  ? 26  SER M CA  1 
ATOM   3388 C  C   . SER D 1 25  ? 2.773   -43.890 30.599  1.00 22.06  ? 26  SER M C   1 
ATOM   3389 O  O   . SER D 1 25  ? 1.834   -44.671 30.597  1.00 23.79  ? 26  SER M O   1 
ATOM   3390 C  CB  . SER D 1 25  ? 4.779   -45.381 30.738  1.00 22.57  ? 26  SER M CB  1 
ATOM   3391 O  OG  . SER D 1 25  ? 5.152   -44.892 32.029  1.00 21.05  ? 26  SER M OG  1 
ATOM   3392 N  N   . GLN D 1 26  ? 2.726   -42.706 31.201  1.00 20.05  ? 27  GLN M N   1 
ATOM   3393 C  CA  . GLN D 1 26  ? 1.528   -42.181 31.859  1.00 26.17  ? 27  GLN M CA  1 
ATOM   3394 C  C   . GLN D 1 26  ? 1.596   -40.651 31.806  1.00 26.03  ? 27  GLN M C   1 
ATOM   3395 O  O   . GLN D 1 26  ? 2.678   -40.093 31.604  1.00 24.58  ? 27  GLN M O   1 
ATOM   3396 C  CB  . GLN D 1 26  ? 1.449   -42.667 33.312  1.00 25.98  ? 27  GLN M CB  1 
ATOM   3397 C  CG  . GLN D 1 26  ? 2.443   -41.967 34.255  1.00 21.22  ? 27  GLN M CG  1 
ATOM   3398 C  CD  . GLN D 1 26  ? 2.500   -42.592 35.648  1.00 30.22  ? 27  GLN M CD  1 
ATOM   3399 O  OE1 . GLN D 1 26  ? 2.224   -41.930 36.654  1.00 27.12  ? 27  GLN M OE1 1 
ATOM   3400 N  NE2 . GLN D 1 26  ? 2.873   -43.871 35.710  1.00 24.76  ? 27  GLN M NE2 1 
ATOM   3401 N  N   . ASN D 1 27  A 0.459   -39.967 31.958  1.00 22.82  ? 27  ASN M N   1 
ATOM   3402 C  CA  . ASN D 1 27  A 0.461   -38.508 31.945  1.00 23.85  ? 27  ASN M CA  1 
ATOM   3403 C  C   . ASN D 1 27  A 1.326   -37.964 33.063  1.00 21.03  ? 27  ASN M C   1 
ATOM   3404 O  O   . ASN D 1 27  A 1.274   -38.465 34.176  1.00 18.94  ? 27  ASN M O   1 
ATOM   3405 C  CB  . ASN D 1 27  A -0.959  -37.935 32.090  1.00 21.36  ? 27  ASN M CB  1 
ATOM   3406 C  CG  . ASN D 1 27  A -1.837  -38.250 30.888  1.00 34.90  ? 27  ASN M CG  1 
ATOM   3407 O  OD1 . ASN D 1 27  A -2.293  -39.377 30.720  1.00 41.33  ? 27  ASN M OD1 1 
ATOM   3408 N  ND2 . ASN D 1 27  A -2.066  -37.258 30.049  1.00 31.22  ? 27  ASN M ND2 1 
ATOM   3409 N  N   . VAL D 1 28  B 2.109   -36.932 32.759  1.00 25.52  ? 27  VAL M N   1 
ATOM   3410 C  CA  . VAL D 1 28  B 2.855   -36.224 33.786  1.00 25.16  ? 27  VAL M CA  1 
ATOM   3411 C  C   . VAL D 1 28  B 1.875   -35.428 34.642  1.00 27.38  ? 27  VAL M C   1 
ATOM   3412 O  O   . VAL D 1 28  B 0.744   -35.183 34.231  1.00 22.03  ? 27  VAL M O   1 
ATOM   3413 C  CB  . VAL D 1 28  B 3.926   -35.291 33.177  1.00 20.91  ? 27  VAL M CB  1 
ATOM   3414 C  CG1 . VAL D 1 28  B 4.945   -36.119 32.390  1.00 15.97  ? 27  VAL M CG1 1 
ATOM   3415 C  CG2 . VAL D 1 28  B 3.280   -34.189 32.294  1.00 21.84  ? 27  VAL M CG2 1 
ATOM   3416 N  N   . TYR D 1 29  ? 2.302   -35.043 35.836  1.00 21.73  ? 28  TYR M N   1 
ATOM   3417 C  CA  . TYR D 1 29  ? 1.418   -34.320 36.755  1.00 22.93  ? 28  TYR M CA  1 
ATOM   3418 C  C   . TYR D 1 29  ? 0.865   -33.026 36.146  1.00 24.32  ? 28  TYR M C   1 
ATOM   3419 O  O   . TYR D 1 29  ? 1.620   -32.223 35.589  1.00 26.93  ? 28  TYR M O   1 
ATOM   3420 C  CB  . TYR D 1 29  ? 2.137   -34.037 38.074  1.00 18.71  ? 28  TYR M CB  1 
ATOM   3421 C  CG  . TYR D 1 29  ? 1.240   -33.427 39.133  1.00 25.23  ? 28  TYR M CG  1 
ATOM   3422 C  CD1 . TYR D 1 29  ? 1.314   -32.078 39.437  1.00 28.15  ? 28  TYR M CD1 1 
ATOM   3423 C  CD2 . TYR D 1 29  ? 0.322   -34.203 39.821  1.00 31.82  ? 28  TYR M CD2 1 
ATOM   3424 C  CE1 . TYR D 1 29  ? 0.493   -31.519 40.406  1.00 39.29  ? 28  TYR M CE1 1 
ATOM   3425 C  CE2 . TYR D 1 29  ? -0.502  -33.657 40.788  1.00 32.68  ? 28  TYR M CE2 1 
ATOM   3426 C  CZ  . TYR D 1 29  ? -0.414  -32.316 41.074  1.00 32.38  ? 28  TYR M CZ  1 
ATOM   3427 O  OH  . TYR D 1 29  ? -1.228  -31.768 42.040  1.00 50.33  ? 28  TYR M OH  1 
ATOM   3428 N  N   . SER D 1 30  ? -0.452  -32.835 36.257  1.00 28.44  ? 29  SER M N   1 
ATOM   3429 C  CA  . SER D 1 30  ? -1.144  -31.705 35.637  1.00 24.59  ? 29  SER M CA  1 
ATOM   3430 C  C   . SER D 1 30  ? -0.922  -31.610 34.133  1.00 25.15  ? 29  SER M C   1 
ATOM   3431 O  O   . SER D 1 30  ? -1.021  -30.527 33.561  1.00 28.12  ? 29  SER M O   1 
ATOM   3432 C  CB  . SER D 1 30  ? -0.723  -30.372 36.273  1.00 27.68  ? 29  SER M CB  1 
ATOM   3433 O  OG  . SER D 1 30  ? -0.809  -30.428 37.682  1.00 39.33  ? 29  SER M OG  1 
ATOM   3434 N  N   . ASN D 1 31  ? -0.609  -32.735 33.499  1.00 23.88  ? 30  ASN M N   1 
ATOM   3435 C  CA  . ASN D 1 31  ? -0.295  -32.769 32.066  1.00 29.12  ? 30  ASN M CA  1 
ATOM   3436 C  C   . ASN D 1 31  ? 0.881   -31.913 31.596  1.00 21.90  ? 30  ASN M C   1 
ATOM   3437 O  O   . ASN D 1 31  ? 1.225   -31.963 30.406  1.00 23.52  ? 30  ASN M O   1 
ATOM   3438 C  CB  . ASN D 1 31  ? -1.528  -32.456 31.197  1.00 24.40  ? 30  ASN M CB  1 
ATOM   3439 C  CG  . ASN D 1 31  ? -2.558  -33.536 31.250  1.00 32.13  ? 30  ASN M CG  1 
ATOM   3440 O  OD1 . ASN D 1 31  ? -2.225  -34.723 31.261  1.00 30.90  ? 30  ASN M OD1 1 
ATOM   3441 N  ND2 . ASN D 1 31  ? -3.830  -33.142 31.299  1.00 41.83  ? 30  ASN M ND2 1 
ATOM   3442 N  N   . ASN D 1 32  ? 1.510   -31.136 32.482  1.00 20.78  ? 31  ASN M N   1 
ATOM   3443 C  CA  . ASN D 1 32  ? 2.675   -30.358 32.032  1.00 21.62  ? 31  ASN M CA  1 
ATOM   3444 C  C   . ASN D 1 32  ? 3.918   -30.312 32.932  1.00 22.94  ? 31  ASN M C   1 
ATOM   3445 O  O   . ASN D 1 32  ? 4.810   -29.497 32.696  1.00 20.43  ? 31  ASN M O   1 
ATOM   3446 C  CB  . ASN D 1 32  ? 2.266   -28.922 31.716  1.00 25.13  ? 31  ASN M CB  1 
ATOM   3447 C  CG  . ASN D 1 32  ? 1.934   -28.132 32.967  1.00 28.76  ? 31  ASN M CG  1 
ATOM   3448 O  OD1 . ASN D 1 32  ? 1.631   -28.705 34.016  1.00 26.11  ? 31  ASN M OD1 1 
ATOM   3449 N  ND2 . ASN D 1 32  ? 1.978   -26.818 32.862  1.00 31.08  ? 31  ASN M ND2 1 
ATOM   3450 N  N   . ASN D 1 33  ? 3.985   -31.148 33.965  1.00 18.05  ? 32  ASN M N   1 
ATOM   3451 C  CA  . ASN D 1 33  ? 5.168   -31.138 34.831  1.00 15.82  ? 32  ASN M CA  1 
ATOM   3452 C  C   . ASN D 1 33  ? 6.287   -31.897 34.133  1.00 21.33  ? 32  ASN M C   1 
ATOM   3453 O  O   . ASN D 1 33  ? 6.512   -33.086 34.399  1.00 18.33  ? 32  ASN M O   1 
ATOM   3454 C  CB  . ASN D 1 33  ? 4.860   -31.760 36.191  1.00 20.90  ? 32  ASN M CB  1 
ATOM   3455 C  CG  . ASN D 1 33  ? 5.852   -31.350 37.269  1.00 21.47  ? 32  ASN M CG  1 
ATOM   3456 O  OD1 . ASN D 1 33  ? 6.651   -30.423 37.096  1.00 19.06  ? 32  ASN M OD1 1 
ATOM   3457 N  ND2 . ASN D 1 33  ? 5.796   -32.043 38.403  1.00 20.07  ? 32  ASN M ND2 1 
ATOM   3458 N  N   . LEU D 1 34  ? 6.974   -31.199 33.225  1.00 20.86  ? 33  LEU M N   1 
ATOM   3459 C  CA  . LEU D 1 34  ? 8.013   -31.802 32.378  1.00 19.87  ? 33  LEU M CA  1 
ATOM   3460 C  C   . LEU D 1 34  ? 9.080   -30.752 32.115  1.00 23.24  ? 33  LEU M C   1 
ATOM   3461 O  O   . LEU D 1 34  ? 8.747   -29.599 31.798  1.00 22.07  ? 33  LEU M O   1 
ATOM   3462 C  CB  . LEU D 1 34  ? 7.392   -32.280 31.054  1.00 20.61  ? 33  LEU M CB  1 
ATOM   3463 C  CG  . LEU D 1 34  ? 8.118   -33.144 30.006  1.00 23.39  ? 33  LEU M CG  1 
ATOM   3464 C  CD1 . LEU D 1 34  ? 9.240   -32.395 29.256  1.00 18.75  ? 33  LEU M CD1 1 
ATOM   3465 C  CD2 . LEU D 1 34  ? 8.597   -34.494 30.570  1.00 19.85  ? 33  LEU M CD2 1 
ATOM   3466 N  N   . ALA D 1 35  ? 10.354  -31.136 32.240  1.00 19.73  ? 34  ALA M N   1 
ATOM   3467 C  CA  . ALA D 1 35  ? 11.453  -30.190 32.069  1.00 17.88  ? 34  ALA M CA  1 
ATOM   3468 C  C   . ALA D 1 35  ? 12.572  -30.741 31.171  1.00 19.79  ? 34  ALA M C   1 
ATOM   3469 O  O   . ALA D 1 35  ? 12.708  -31.944 31.013  1.00 17.59  ? 34  ALA M O   1 
ATOM   3470 C  CB  . ALA D 1 35  ? 12.019  -29.786 33.425  1.00 18.09  ? 34  ALA M CB  1 
ATOM   3471 N  N   . TRP D 1 36  ? 13.365  -29.847 30.588  1.00 16.99  ? 35  TRP M N   1 
ATOM   3472 C  CA  . TRP D 1 36  ? 14.512  -30.245 29.774  1.00 16.01  ? 35  TRP M CA  1 
ATOM   3473 C  C   . TRP D 1 36  ? 15.813  -29.663 30.302  1.00 16.77  ? 35  TRP M C   1 
ATOM   3474 O  O   . TRP D 1 36  ? 15.853  -28.501 30.748  1.00 16.35  ? 35  TRP M O   1 
ATOM   3475 C  CB  . TRP D 1 36  ? 14.326  -29.767 28.329  1.00 17.98  ? 35  TRP M CB  1 
ATOM   3476 C  CG  . TRP D 1 36  ? 13.173  -30.416 27.625  1.00 16.93  ? 35  TRP M CG  1 
ATOM   3477 C  CD1 . TRP D 1 36  ? 11.867  -29.988 27.598  1.00 19.41  ? 35  TRP M CD1 1 
ATOM   3478 C  CD2 . TRP D 1 36  ? 13.219  -31.615 26.854  1.00 16.48  ? 35  TRP M CD2 1 
ATOM   3479 N  NE1 . TRP D 1 36  ? 11.111  -30.839 26.834  1.00 15.42  ? 35  TRP M NE1 1 
ATOM   3480 C  CE2 . TRP D 1 36  ? 11.913  -31.848 26.364  1.00 16.01  ? 35  TRP M CE2 1 
ATOM   3481 C  CE3 . TRP D 1 36  ? 14.244  -32.504 26.508  1.00 15.96  ? 35  TRP M CE3 1 
ATOM   3482 C  CZ2 . TRP D 1 36  ? 11.601  -32.945 25.551  1.00 16.39  ? 35  TRP M CZ2 1 
ATOM   3483 C  CZ3 . TRP D 1 36  ? 13.937  -33.591 25.699  1.00 16.53  ? 35  TRP M CZ3 1 
ATOM   3484 C  CH2 . TRP D 1 36  ? 12.621  -33.806 25.234  1.00 18.67  ? 35  TRP M CH2 1 
ATOM   3485 N  N   . PHE D 1 37  ? 16.883  -30.449 30.201  1.00 16.42  ? 36  PHE M N   1 
ATOM   3486 C  CA  . PHE D 1 37  ? 18.184  -30.087 30.752  1.00 15.56  ? 36  PHE M CA  1 
ATOM   3487 C  C   . PHE D 1 37  ? 19.304  -30.236 29.741  1.00 19.03  ? 36  PHE M C   1 
ATOM   3488 O  O   . PHE D 1 37  ? 19.230  -31.078 28.843  1.00 17.73  ? 36  PHE M O   1 
ATOM   3489 C  CB  . PHE D 1 37  ? 18.555  -30.991 31.944  1.00 15.98  ? 36  PHE M CB  1 
ATOM   3490 C  CG  . PHE D 1 37  ? 17.658  -30.832 33.138  1.00 16.78  ? 36  PHE M CG  1 
ATOM   3491 C  CD1 . PHE D 1 37  ? 16.483  -31.551 33.225  1.00 16.18  ? 36  PHE M CD1 1 
ATOM   3492 C  CD2 . PHE D 1 37  ? 17.997  -29.968 34.178  1.00 16.66  ? 36  PHE M CD2 1 
ATOM   3493 C  CE1 . PHE D 1 37  ? 15.649  -31.412 34.320  1.00 16.46  ? 36  PHE M CE1 1 
ATOM   3494 C  CE2 . PHE D 1 37  ? 17.162  -29.819 35.274  1.00 13.73  ? 36  PHE M CE2 1 
ATOM   3495 C  CZ  . PHE D 1 37  ? 15.986  -30.546 35.343  1.00 16.78  ? 36  PHE M CZ  1 
ATOM   3496 N  N   . GLN D 1 38  ? 20.371  -29.467 29.944  1.00 14.55  ? 37  GLN M N   1 
ATOM   3497 C  CA  . GLN D 1 38  ? 21.600  -29.619 29.164  1.00 20.03  ? 37  GLN M CA  1 
ATOM   3498 C  C   . GLN D 1 38  ? 22.706  -30.018 30.128  1.00 21.45  ? 37  GLN M C   1 
ATOM   3499 O  O   . GLN D 1 38  ? 22.826  -29.419 31.190  1.00 16.62  ? 37  GLN M O   1 
ATOM   3500 C  CB  . GLN D 1 38  ? 21.991  -28.291 28.508  1.00 17.05  ? 37  GLN M CB  1 
ATOM   3501 C  CG  . GLN D 1 38  ? 23.298  -28.346 27.670  1.00 16.87  ? 37  GLN M CG  1 
ATOM   3502 C  CD  . GLN D 1 38  ? 23.747  -26.959 27.195  1.00 27.89  ? 37  GLN M CD  1 
ATOM   3503 O  OE1 . GLN D 1 38  ? 23.719  -25.992 27.956  1.00 25.17  ? 37  GLN M OE1 1 
ATOM   3504 N  NE2 . GLN D 1 38  ? 24.176  -26.867 25.941  1.00 20.99  ? 37  GLN M NE2 1 
ATOM   3505 N  N   . GLN D 1 39  ? 23.516  -31.014 29.770  1.00 15.90  ? 38  GLN M N   1 
ATOM   3506 C  CA  . GLN D 1 39  ? 24.680  -31.345 30.604  1.00 18.90  ? 38  GLN M CA  1 
ATOM   3507 C  C   . GLN D 1 39  ? 25.970  -31.519 29.795  1.00 21.22  ? 38  GLN M C   1 
ATOM   3508 O  O   . GLN D 1 39  ? 26.035  -32.332 28.867  1.00 20.82  ? 38  GLN M O   1 
ATOM   3509 C  CB  . GLN D 1 39  ? 24.426  -32.619 31.421  1.00 17.15  ? 38  GLN M CB  1 
ATOM   3510 C  CG  . GLN D 1 39  ? 25.598  -32.972 32.374  1.00 17.98  ? 38  GLN M CG  1 
ATOM   3511 C  CD  . GLN D 1 39  ? 25.436  -34.313 33.078  1.00 21.35  ? 38  GLN M CD  1 
ATOM   3512 O  OE1 . GLN D 1 39  ? 24.893  -35.264 32.522  1.00 23.19  ? 38  GLN M OE1 1 
ATOM   3513 N  NE2 . GLN D 1 39  ? 25.910  -34.387 34.313  1.00 20.12  ? 38  GLN M NE2 1 
ATOM   3514 N  N   . LYS D 1 40  ? 26.998  -30.766 30.151  1.00 21.08  ? 39  LYS M N   1 
ATOM   3515 C  CA  . LYS D 1 40  ? 28.306  -30.945 29.524  1.00 24.33  ? 39  LYS M CA  1 
ATOM   3516 C  C   . LYS D 1 40  ? 29.176  -31.797 30.428  1.00 27.74  ? 39  LYS M C   1 
ATOM   3517 O  O   . LYS D 1 40  ? 28.924  -31.853 31.620  1.00 26.96  ? 39  LYS M O   1 
ATOM   3518 C  CB  . LYS D 1 40  ? 28.952  -29.593 29.243  1.00 28.05  ? 39  LYS M CB  1 
ATOM   3519 C  CG  . LYS D 1 40  ? 28.230  -28.816 28.156  1.00 27.68  ? 39  LYS M CG  1 
ATOM   3520 C  CD  . LYS D 1 40  ? 28.976  -27.564 27.758  1.00 33.42  ? 39  LYS M CD  1 
ATOM   3521 C  CE  . LYS D 1 40  ? 28.324  -26.956 26.526  1.00 32.18  ? 39  LYS M CE  1 
ATOM   3522 N  NZ  . LYS D 1 40  ? 29.008  -25.726 26.061  1.00 26.60  ? 39  LYS M NZ  1 
ATOM   3523 N  N   . PRO D 1 41  ? 30.187  -32.484 29.858  1.00 34.83  ? 40  PRO M N   1 
ATOM   3524 C  CA  . PRO D 1 41  ? 31.052  -33.382 30.636  1.00 34.07  ? 40  PRO M CA  1 
ATOM   3525 C  C   . PRO D 1 41  ? 31.700  -32.716 31.853  1.00 31.24  ? 40  PRO M C   1 
ATOM   3526 O  O   . PRO D 1 41  ? 32.226  -31.609 31.748  1.00 29.03  ? 40  PRO M O   1 
ATOM   3527 C  CB  . PRO D 1 41  ? 32.121  -33.795 29.621  1.00 40.85  ? 40  PRO M CB  1 
ATOM   3528 C  CG  . PRO D 1 41  ? 31.426  -33.706 28.308  1.00 35.71  ? 40  PRO M CG  1 
ATOM   3529 C  CD  . PRO D 1 41  ? 30.517  -32.523 28.418  1.00 37.79  ? 40  PRO M CD  1 
ATOM   3530 N  N   . GLY D 1 42  ? 31.627  -33.393 32.999  1.00 32.11  ? 41  GLY M N   1 
ATOM   3531 C  CA  . GLY D 1 42  ? 32.191  -32.897 34.239  1.00 29.84  ? 41  GLY M CA  1 
ATOM   3532 C  C   . GLY D 1 42  ? 31.343  -31.869 34.967  1.00 33.02  ? 41  GLY M C   1 
ATOM   3533 O  O   . GLY D 1 42  ? 31.712  -31.426 36.052  1.00 31.86  ? 41  GLY M O   1 
ATOM   3534 N  N   . GLN D 1 43  ? 30.201  -31.505 34.387  1.00 24.39  ? 42  GLN M N   1 
ATOM   3535 C  CA  . GLN D 1 43  ? 29.357  -30.445 34.942  1.00 28.31  ? 42  GLN M CA  1 
ATOM   3536 C  C   . GLN D 1 43  ? 28.012  -30.975 35.402  1.00 19.50  ? 42  GLN M C   1 
ATOM   3537 O  O   . GLN D 1 43  ? 27.597  -32.049 34.971  1.00 22.51  ? 42  GLN M O   1 
ATOM   3538 C  CB  . GLN D 1 43  ? 29.122  -29.375 33.875  1.00 32.50  ? 42  GLN M CB  1 
ATOM   3539 C  CG  . GLN D 1 43  ? 30.376  -28.721 33.388  1.00 32.29  ? 42  GLN M CG  1 
ATOM   3540 C  CD  . GLN D 1 43  ? 30.346  -27.250 33.644  1.00 60.34  ? 42  GLN M CD  1 
ATOM   3541 O  OE1 . GLN D 1 43  ? 29.870  -26.475 32.810  1.00 68.47  ? 42  GLN M OE1 1 
ATOM   3542 N  NE2 . GLN D 1 43  ? 30.832  -26.843 34.818  1.00 58.29  ? 42  GLN M NE2 1 
ATOM   3543 N  N   . PRO D 1 44  ? 27.330  -30.238 36.295  1.00 18.38  ? 43  PRO M N   1 
ATOM   3544 C  CA  . PRO D 1 44  ? 25.954  -30.610 36.647  1.00 22.02  ? 43  PRO M CA  1 
ATOM   3545 C  C   . PRO D 1 44  ? 24.991  -30.199 35.527  1.00 21.40  ? 43  PRO M C   1 
ATOM   3546 O  O   . PRO D 1 44  ? 25.317  -29.311 34.734  1.00 22.28  ? 43  PRO M O   1 
ATOM   3547 C  CB  . PRO D 1 44  ? 25.671  -29.751 37.888  1.00 26.77  ? 43  PRO M CB  1 
ATOM   3548 C  CG  . PRO D 1 44  ? 26.555  -28.526 37.701  1.00 23.44  ? 43  PRO M CG  1 
ATOM   3549 C  CD  . PRO D 1 44  ? 27.804  -29.057 37.055  1.00 25.43  ? 43  PRO M CD  1 
ATOM   3550 N  N   . PRO D 1 45  ? 23.808  -30.816 35.482  1.00 20.12  ? 44  PRO M N   1 
ATOM   3551 C  CA  . PRO D 1 45  ? 22.741  -30.441 34.550  1.00 16.62  ? 44  PRO M CA  1 
ATOM   3552 C  C   . PRO D 1 45  ? 22.328  -28.993 34.746  1.00 20.81  ? 44  PRO M C   1 
ATOM   3553 O  O   . PRO D 1 45  ? 22.399  -28.487 35.865  1.00 20.91  ? 44  PRO M O   1 
ATOM   3554 C  CB  . PRO D 1 45  ? 21.584  -31.350 34.982  1.00 20.37  ? 44  PRO M CB  1 
ATOM   3555 C  CG  . PRO D 1 45  ? 22.226  -32.480 35.659  1.00 23.05  ? 44  PRO M CG  1 
ATOM   3556 C  CD  . PRO D 1 45  ? 23.385  -31.908 36.375  1.00 18.61  ? 44  PRO M CD  1 
ATOM   3557 N  N   . ARG D 1 46  ? 21.887  -28.353 33.667  1.00 22.90  ? 45  ARG M N   1 
ATOM   3558 C  CA  . ARG D 1 46  ? 21.411  -26.970 33.678  1.00 19.11  ? 45  ARG M CA  1 
ATOM   3559 C  C   . ARG D 1 46  ? 19.952  -26.981 33.206  1.00 18.58  ? 45  ARG M C   1 
ATOM   3560 O  O   . ARG D 1 46  ? 19.651  -27.545 32.150  1.00 15.75  ? 45  ARG M O   1 
ATOM   3561 C  CB  . ARG D 1 46  ? 22.262  -26.150 32.710  1.00 22.35  ? 45  ARG M CB  1 
ATOM   3562 C  CG  . ARG D 1 46  ? 21.791  -24.726 32.446  1.00 28.59  ? 45  ARG M CG  1 
ATOM   3563 C  CD  . ARG D 1 46  ? 22.483  -24.204 31.184  1.00 30.10  ? 45  ARG M CD  1 
ATOM   3564 N  NE  . ARG D 1 46  ? 22.215  -22.798 30.909  1.00 39.96  ? 45  ARG M NE  1 
ATOM   3565 C  CZ  . ARG D 1 46  ? 22.364  -22.233 29.711  1.00 44.19  ? 45  ARG M CZ  1 
ATOM   3566 N  NH1 . ARG D 1 46  ? 22.106  -20.943 29.559  1.00 30.64  ? 45  ARG M NH1 1 
ATOM   3567 N  NH2 . ARG D 1 46  ? 22.764  -22.962 28.661  1.00 36.73  ? 45  ARG M NH2 1 
ATOM   3568 N  N   . LEU D 1 47  ? 19.056  -26.377 33.987  1.00 14.64  ? 46  LEU M N   1 
ATOM   3569 C  CA  . LEU D 1 47  ? 17.642  -26.328 33.636  1.00 19.43  ? 46  LEU M CA  1 
ATOM   3570 C  C   . LEU D 1 47  ? 17.455  -25.373 32.467  1.00 17.78  ? 46  LEU M C   1 
ATOM   3571 O  O   . LEU D 1 47  ? 17.888  -24.232 32.539  1.00 19.81  ? 46  LEU M O   1 
ATOM   3572 C  CB  . LEU D 1 47  ? 16.798  -25.845 34.838  1.00 17.29  ? 46  LEU M CB  1 
ATOM   3573 C  CG  . LEU D 1 47  ? 15.286  -25.718 34.624  1.00 20.34  ? 46  LEU M CG  1 
ATOM   3574 C  CD1 . LEU D 1 47  ? 14.656  -27.066 34.256  1.00 16.79  ? 46  LEU M CD1 1 
ATOM   3575 C  CD2 . LEU D 1 47  ? 14.586  -25.124 35.849  1.00 19.24  ? 46  LEU M CD2 1 
ATOM   3576 N  N   . LEU D 1 48  ? 16.792  -25.832 31.409  1.00 19.30  ? 47  LEU M N   1 
ATOM   3577 C  CA  . LEU D 1 48  ? 16.516  -24.999 30.235  1.00 19.59  ? 47  LEU M CA  1 
ATOM   3578 C  C   . LEU D 1 48  ? 15.029  -24.630 30.128  1.00 24.30  ? 47  LEU M C   1 
ATOM   3579 O  O   . LEU D 1 48  ? 14.675  -23.452 29.949  1.00 20.04  ? 47  LEU M O   1 
ATOM   3580 C  CB  . LEU D 1 48  ? 16.947  -25.719 28.959  1.00 18.22  ? 47  LEU M CB  1 
ATOM   3581 C  CG  . LEU D 1 48  ? 18.413  -26.147 28.839  1.00 22.64  ? 47  LEU M CG  1 
ATOM   3582 C  CD1 . LEU D 1 48  ? 18.627  -26.997 27.582  1.00 21.52  ? 47  LEU M CD1 1 
ATOM   3583 C  CD2 . LEU D 1 48  ? 19.336  -24.935 28.821  1.00 19.90  ? 47  LEU M CD2 1 
ATOM   3584 N  N   . ILE D 1 49  ? 14.162  -25.637 30.232  1.00 20.03  ? 48  ILE M N   1 
ATOM   3585 C  CA  . ILE D 1 49  ? 12.719  -25.451 30.087  1.00 22.53  ? 48  ILE M CA  1 
ATOM   3586 C  C   . ILE D 1 49  ? 11.997  -26.162 31.231  1.00 25.06  ? 48  ILE M C   1 
ATOM   3587 O  O   . ILE D 1 49  ? 12.383  -27.266 31.606  1.00 22.23  ? 48  ILE M O   1 
ATOM   3588 C  CB  . ILE D 1 49  ? 12.212  -26.091 28.782  1.00 20.01  ? 48  ILE M CB  1 
ATOM   3589 C  CG1 . ILE D 1 49  ? 13.008  -25.607 27.567  1.00 23.84  ? 48  ILE M CG1 1 
ATOM   3590 C  CG2 . ILE D 1 49  ? 10.720  -25.864 28.604  1.00 23.30  ? 48  ILE M CG2 1 
ATOM   3591 C  CD1 . ILE D 1 49  ? 12.594  -24.243 27.066  1.00 29.03  ? 48  ILE M CD1 1 
ATOM   3592 N  N   . TYR D 1 50  ? 10.948  -25.553 31.779  1.00 22.30  ? 49  TYR M N   1 
ATOM   3593 C  CA  . TYR D 1 50  ? 10.096  -26.256 32.741  1.00 20.38  ? 49  TYR M CA  1 
ATOM   3594 C  C   . TYR D 1 50  ? 8.632   -25.998 32.422  1.00 24.31  ? 49  TYR M C   1 
ATOM   3595 O  O   . TYR D 1 50  ? 8.319   -25.133 31.589  1.00 21.96  ? 49  TYR M O   1 
ATOM   3596 C  CB  . TYR D 1 50  ? 10.429  -25.859 34.188  1.00 21.66  ? 49  TYR M CB  1 
ATOM   3597 C  CG  . TYR D 1 50  ? 10.138  -24.402 34.501  1.00 26.06  ? 49  TYR M CG  1 
ATOM   3598 C  CD1 . TYR D 1 50  ? 11.061  -23.402 34.190  1.00 30.38  ? 49  TYR M CD1 1 
ATOM   3599 C  CD2 . TYR D 1 50  ? 8.938   -24.027 35.094  1.00 27.10  ? 49  TYR M CD2 1 
ATOM   3600 C  CE1 . TYR D 1 50  ? 10.797  -22.062 34.468  1.00 30.30  ? 49  TYR M CE1 1 
ATOM   3601 C  CE2 . TYR D 1 50  ? 8.663   -22.697 35.375  1.00 35.44  ? 49  TYR M CE2 1 
ATOM   3602 C  CZ  . TYR D 1 50  ? 9.593   -21.720 35.062  1.00 34.66  ? 49  TYR M CZ  1 
ATOM   3603 O  OH  . TYR D 1 50  ? 9.318   -20.403 35.345  1.00 46.03  ? 49  TYR M OH  1 
ATOM   3604 N  N   . ASP D 1 51  ? 7.743   -26.764 33.059  1.00 20.38  ? 50  ASP M N   1 
ATOM   3605 C  CA  . ASP D 1 51  ? 6.318   -26.698 32.750  1.00 25.83  ? 50  ASP M CA  1 
ATOM   3606 C  C   . ASP D 1 51  ? 6.066   -26.903 31.244  1.00 27.45  ? 50  ASP M C   1 
ATOM   3607 O  O   . ASP D 1 51  ? 5.202   -26.237 30.653  1.00 22.85  ? 50  ASP M O   1 
ATOM   3608 C  CB  . ASP D 1 51  ? 5.729   -25.352 33.214  1.00 24.83  ? 50  ASP M CB  1 
ATOM   3609 C  CG  . ASP D 1 51  ? 5.516   -25.279 34.728  1.00 33.77  ? 50  ASP M CG  1 
ATOM   3610 O  OD1 . ASP D 1 51  ? 5.009   -24.241 35.201  1.00 32.16  ? 50  ASP M OD1 1 
ATOM   3611 O  OD2 . ASP D 1 51  ? 5.840   -26.245 35.447  1.00 25.37  ? 50  ASP M OD2 1 
ATOM   3612 N  N   . ALA D 1 52  ? 6.838   -27.812 30.640  1.00 22.64  ? 51  ALA M N   1 
ATOM   3613 C  CA  . ALA D 1 52  ? 6.730   -28.194 29.213  1.00 20.94  ? 51  ALA M CA  1 
ATOM   3614 C  C   . ALA D 1 52  ? 7.268   -27.155 28.222  1.00 22.75  ? 51  ALA M C   1 
ATOM   3615 O  O   . ALA D 1 52  ? 7.929   -27.515 27.229  1.00 19.98  ? 51  ALA M O   1 
ATOM   3616 C  CB  . ALA D 1 52  ? 5.288   -28.620 28.836  1.00 22.34  ? 51  ALA M CB  1 
ATOM   3617 N  N   . SER D 1 53  ? 7.014   -25.874 28.497  1.00 16.82  ? 52  SER M N   1 
ATOM   3618 C  CA  . SER D 1 53  ? 7.313   -24.817 27.522  1.00 19.39  ? 52  SER M CA  1 
ATOM   3619 C  C   . SER D 1 53  ? 7.829   -23.490 28.067  1.00 22.13  ? 52  SER M C   1 
ATOM   3620 O  O   . SER D 1 53  ? 8.098   -22.581 27.283  1.00 24.65  ? 52  SER M O   1 
ATOM   3621 C  CB  . SER D 1 53  ? 6.074   -24.536 26.658  1.00 24.06  ? 52  SER M CB  1 
ATOM   3622 O  OG  . SER D 1 53  ? 5.021   -24.058 27.481  1.00 24.77  ? 52  SER M OG  1 
ATOM   3623 N  N   . LYS D 1 54  ? 7.983   -23.360 29.383  1.00 21.71  ? 53  LYS M N   1 
ATOM   3624 C  CA  . LYS D 1 54  ? 8.480   -22.106 29.942  1.00 23.61  ? 53  LYS M CA  1 
ATOM   3625 C  C   . LYS D 1 54  ? 10.002  -22.075 29.973  1.00 26.83  ? 53  LYS M C   1 
ATOM   3626 O  O   . LYS D 1 54  ? 10.643  -23.047 30.382  1.00 21.14  ? 53  LYS M O   1 
ATOM   3627 C  CB  . LYS D 1 54  ? 7.906   -21.850 31.340  1.00 26.88  ? 53  LYS M CB  1 
ATOM   3628 C  CG  . LYS D 1 54  ? 6.388   -21.671 31.338  1.00 35.57  ? 53  LYS M CG  1 
ATOM   3629 C  CD  . LYS D 1 54  ? 5.781   -21.666 32.741  1.00 39.69  ? 53  LYS M CD  1 
ATOM   3630 C  CE  . LYS D 1 54  ? 4.252   -21.680 32.658  1.00 42.57  ? 53  LYS M CE  1 
ATOM   3631 N  NZ  . LYS D 1 54  ? 3.621   -22.469 33.751  1.00 37.31  ? 53  LYS M NZ  1 
ATOM   3632 N  N   . LEU D 1 55  ? 10.571  -20.948 29.547  1.00 22.00  ? 54  LEU M N   1 
ATOM   3633 C  CA  . LEU D 1 55  ? 12.025  -20.761 29.455  1.00 23.42  ? 54  LEU M CA  1 
ATOM   3634 C  C   . LEU D 1 55  ? 12.598  -20.369 30.811  1.00 30.37  ? 54  LEU M C   1 
ATOM   3635 O  O   . LEU D 1 55  ? 12.129  -19.411 31.430  1.00 30.86  ? 54  LEU M O   1 
ATOM   3636 C  CB  . LEU D 1 55  ? 12.339  -19.623 28.485  1.00 31.26  ? 54  LEU M CB  1 
ATOM   3637 C  CG  . LEU D 1 55  ? 13.071  -19.804 27.157  1.00 39.68  ? 54  LEU M CG  1 
ATOM   3638 C  CD1 . LEU D 1 55  ? 13.641  -18.447 26.716  1.00 33.75  ? 54  LEU M CD1 1 
ATOM   3639 C  CD2 . LEU D 1 55  ? 14.162  -20.857 27.213  1.00 26.66  ? 54  LEU M CD2 1 
ATOM   3640 N  N   . ALA D 1 56  ? 13.616  -21.084 31.274  1.00 30.13  ? 55  ALA M N   1 
ATOM   3641 C  CA  . ALA D 1 56  ? 14.255  -20.722 32.537  1.00 33.74  ? 55  ALA M CA  1 
ATOM   3642 C  C   . ALA D 1 56  ? 14.956  -19.380 32.375  1.00 27.98  ? 55  ALA M C   1 
ATOM   3643 O  O   . ALA D 1 56  ? 15.417  -19.043 31.288  1.00 24.31  ? 55  ALA M O   1 
ATOM   3644 C  CB  . ALA D 1 56  ? 15.243  -21.795 32.987  1.00 31.65  ? 55  ALA M CB  1 
ATOM   3645 N  N   . SER D 1 57  ? 15.018  -18.609 33.455  1.00 33.31  ? 56  SER M N   1 
ATOM   3646 C  CA  . SER D 1 57  ? 15.586  -17.270 33.394  1.00 33.73  ? 56  SER M CA  1 
ATOM   3647 C  C   . SER D 1 57  ? 17.034  -17.321 32.895  1.00 30.67  ? 56  SER M C   1 
ATOM   3648 O  O   . SER D 1 57  ? 17.834  -18.119 33.376  1.00 32.70  ? 56  SER M O   1 
ATOM   3649 C  CB  . SER D 1 57  ? 15.496  -16.602 34.775  1.00 44.20  ? 56  SER M CB  1 
ATOM   3650 O  OG  . SER D 1 57  ? 15.939  -15.256 34.731  1.00 49.65  ? 56  SER M OG  1 
ATOM   3651 N  N   . GLY D 1 58  ? 17.359  -16.510 31.891  1.00 28.36  ? 57  GLY M N   1 
ATOM   3652 C  CA  . GLY D 1 58  ? 18.718  -16.461 31.368  1.00 29.76  ? 57  GLY M CA  1 
ATOM   3653 C  C   . GLY D 1 58  ? 19.056  -17.490 30.294  1.00 33.89  ? 57  GLY M C   1 
ATOM   3654 O  O   . GLY D 1 58  ? 20.205  -17.601 29.861  1.00 34.91  ? 57  GLY M O   1 
ATOM   3655 N  N   . VAL D 1 59  ? 18.060  -18.253 29.862  1.00 33.00  ? 58  VAL M N   1 
ATOM   3656 C  CA  . VAL D 1 59  ? 18.261  -19.242 28.804  1.00 27.34  ? 58  VAL M CA  1 
ATOM   3657 C  C   . VAL D 1 59  ? 17.863  -18.629 27.458  1.00 28.77  ? 58  VAL M C   1 
ATOM   3658 O  O   . VAL D 1 59  ? 16.800  -18.005 27.356  1.00 27.06  ? 58  VAL M O   1 
ATOM   3659 C  CB  . VAL D 1 59  ? 17.440  -20.511 29.098  1.00 27.18  ? 58  VAL M CB  1 
ATOM   3660 C  CG1 . VAL D 1 59  ? 17.534  -21.512 27.955  1.00 27.20  ? 58  VAL M CG1 1 
ATOM   3661 C  CG2 . VAL D 1 59  ? 17.926  -21.143 30.396  1.00 28.60  ? 58  VAL M CG2 1 
ATOM   3662 N  N   . PRO D 1 60  ? 18.717  -18.786 26.429  1.00 28.62  ? 59  PRO M N   1 
ATOM   3663 C  CA  . PRO D 1 60  ? 18.471  -18.228 25.086  1.00 30.90  ? 59  PRO M CA  1 
ATOM   3664 C  C   . PRO D 1 60  ? 17.148  -18.705 24.488  1.00 34.13  ? 59  PRO M C   1 
ATOM   3665 O  O   . PRO D 1 60  ? 16.775  -19.869 24.667  1.00 29.26  ? 59  PRO M O   1 
ATOM   3666 C  CB  . PRO D 1 60  ? 19.633  -18.784 24.253  1.00 32.79  ? 59  PRO M CB  1 
ATOM   3667 C  CG  . PRO D 1 60  ? 20.705  -19.095 25.241  1.00 37.38  ? 59  PRO M CG  1 
ATOM   3668 C  CD  . PRO D 1 60  ? 20.001  -19.506 26.504  1.00 34.21  ? 59  PRO M CD  1 
ATOM   3669 N  N   . SER D 1 61  ? 16.461  -17.828 23.765  1.00 27.35  ? 60  SER M N   1 
ATOM   3670 C  CA  . SER D 1 61  ? 15.131  -18.145 23.235  1.00 33.56  ? 60  SER M CA  1 
ATOM   3671 C  C   . SER D 1 61  ? 15.149  -19.034 21.987  1.00 26.01  ? 60  SER M C   1 
ATOM   3672 O  O   . SER D 1 61  ? 14.093  -19.363 21.433  1.00 25.80  ? 60  SER M O   1 
ATOM   3673 C  CB  . SER D 1 61  ? 14.379  -16.861 22.914  1.00 30.39  ? 60  SER M CB  1 
ATOM   3674 O  OG  . SER D 1 61  ? 15.109  -16.128 21.945  1.00 39.99  ? 60  SER M OG  1 
ATOM   3675 N  N   . ARG D 1 62  ? 16.338  -19.411 21.531  1.00 28.07  ? 61  ARG M N   1 
ATOM   3676 C  CA  . ARG D 1 62  ? 16.421  -20.413 20.468  1.00 28.06  ? 61  ARG M CA  1 
ATOM   3677 C  C   . ARG D 1 62  ? 16.167  -21.825 21.005  1.00 24.88  ? 61  ARG M C   1 
ATOM   3678 O  O   . ARG D 1 62  ? 16.060  -22.786 20.229  1.00 23.62  ? 61  ARG M O   1 
ATOM   3679 C  CB  . ARG D 1 62  ? 17.749  -20.320 19.723  1.00 31.00  ? 61  ARG M CB  1 
ATOM   3680 C  CG  . ARG D 1 62  ? 18.942  -20.357 20.615  1.00 34.78  ? 61  ARG M CG  1 
ATOM   3681 C  CD  . ARG D 1 62  ? 20.206  -19.833 19.904  1.00 38.13  ? 61  ARG M CD  1 
ATOM   3682 N  NE  . ARG D 1 62  ? 21.348  -20.109 20.764  1.00 36.72  ? 61  ARG M NE  1 
ATOM   3683 C  CZ  . ARG D 1 62  ? 21.926  -21.298 20.836  1.00 32.50  ? 61  ARG M CZ  1 
ATOM   3684 N  NH1 . ARG D 1 62  ? 22.928  -21.500 21.673  1.00 24.91  ? 61  ARG M NH1 1 
ATOM   3685 N  NH2 . ARG D 1 62  ? 21.487  -22.283 20.060  1.00 22.02  ? 61  ARG M NH2 1 
ATOM   3686 N  N   . PHE D 1 63  ? 16.051  -21.944 22.328  1.00 21.11  ? 62  PHE M N   1 
ATOM   3687 C  CA  . PHE D 1 63  ? 15.587  -23.190 22.962  1.00 21.16  ? 62  PHE M CA  1 
ATOM   3688 C  C   . PHE D 1 63  ? 14.089  -23.144 23.156  1.00 26.79  ? 62  PHE M C   1 
ATOM   3689 O  O   . PHE D 1 63  ? 13.565  -22.195 23.725  1.00 24.23  ? 62  PHE M O   1 
ATOM   3690 C  CB  . PHE D 1 63  ? 16.235  -23.411 24.332  1.00 24.59  ? 62  PHE M CB  1 
ATOM   3691 C  CG  . PHE D 1 63  ? 17.710  -23.669 24.277  1.00 26.93  ? 62  PHE M CG  1 
ATOM   3692 C  CD1 . PHE D 1 63  ? 18.203  -24.794 23.654  1.00 29.24  ? 62  PHE M CD1 1 
ATOM   3693 C  CD2 . PHE D 1 63  ? 18.602  -22.808 24.880  1.00 35.48  ? 62  PHE M CD2 1 
ATOM   3694 C  CE1 . PHE D 1 63  ? 19.565  -25.038 23.605  1.00 33.76  ? 62  PHE M CE1 1 
ATOM   3695 C  CE2 . PHE D 1 63  ? 19.963  -23.053 24.837  1.00 36.99  ? 62  PHE M CE2 1 
ATOM   3696 C  CZ  . PHE D 1 63  ? 20.443  -24.170 24.199  1.00 25.44  ? 62  PHE M CZ  1 
ATOM   3697 N  N   . LYS D 1 64  ? 13.400  -24.191 22.719  1.00 20.95  ? 63  LYS M N   1 
ATOM   3698 C  CA  . LYS D 1 64  ? 11.955  -24.205 22.792  1.00 19.88  ? 63  LYS M CA  1 
ATOM   3699 C  C   . LYS D 1 64  ? 11.434  -25.606 23.129  1.00 22.43  ? 63  LYS M C   1 
ATOM   3700 O  O   . LYS D 1 64  ? 11.918  -26.600 22.593  1.00 24.09  ? 63  LYS M O   1 
ATOM   3701 C  CB  . LYS D 1 64  ? 11.396  -23.681 21.459  1.00 22.29  ? 63  LYS M CB  1 
ATOM   3702 C  CG  . LYS D 1 64  ? 9.970   -24.034 21.166  1.00 32.92  ? 63  LYS M CG  1 
ATOM   3703 C  CD  . LYS D 1 64  ? 9.498   -23.384 19.848  1.00 49.68  ? 63  LYS M CD  1 
ATOM   3704 C  CE  . LYS D 1 64  ? 10.486  -23.607 18.688  1.00 61.11  ? 63  LYS M CE  1 
ATOM   3705 N  NZ  . LYS D 1 64  ? 10.207  -24.793 17.806  1.00 52.84  ? 63  LYS M NZ  1 
ATOM   3706 N  N   . GLY D 1 65  ? 10.462  -25.689 24.035  1.00 18.84  ? 64  GLY M N   1 
ATOM   3707 C  CA  . GLY D 1 65  ? 9.786   -26.942 24.308  1.00 19.74  ? 64  GLY M CA  1 
ATOM   3708 C  C   . GLY D 1 65  ? 8.290   -26.865 24.016  1.00 30.93  ? 64  GLY M C   1 
ATOM   3709 O  O   . GLY D 1 65  ? 7.688   -25.791 24.091  1.00 24.23  ? 64  GLY M O   1 
ATOM   3710 N  N   . SER D 1 66  ? 7.685   -27.994 23.663  1.00 20.02  ? 65  SER M N   1 
ATOM   3711 C  CA  . SER D 1 66  ? 6.223   -28.061 23.566  1.00 25.67  ? 65  SER M CA  1 
ATOM   3712 C  C   . SER D 1 66  ? 5.695   -29.467 23.825  1.00 27.49  ? 65  SER M C   1 
ATOM   3713 O  O   . SER D 1 66  ? 6.472   -30.427 23.932  1.00 24.32  ? 65  SER M O   1 
ATOM   3714 C  CB  . SER D 1 66  ? 5.733   -27.559 22.202  1.00 35.45  ? 65  SER M CB  1 
ATOM   3715 O  OG  . SER D 1 66  ? 6.085   -28.469 21.187  1.00 37.98  ? 65  SER M OG  1 
ATOM   3716 N  N   . GLY D 1 67  ? 4.371   -29.591 23.940  1.00 21.82  ? 66  GLY M N   1 
ATOM   3717 C  CA  . GLY D 1 67  ? 3.761   -30.883 24.181  1.00 24.88  ? 66  GLY M CA  1 
ATOM   3718 C  C   . GLY D 1 67  ? 2.918   -30.866 25.436  1.00 25.94  ? 66  GLY M C   1 
ATOM   3719 O  O   . GLY D 1 67  ? 2.851   -29.852 26.121  1.00 27.56  ? 66  GLY M O   1 
ATOM   3720 N  N   . SER D 1 68  ? 2.300   -31.999 25.750  1.00 24.53  ? 67  SER M N   1 
ATOM   3721 C  CA  . SER D 1 68  ? 1.369   -32.085 26.869  1.00 26.46  ? 67  SER M CA  1 
ATOM   3722 C  C   . SER D 1 68  ? 0.978   -33.547 27.103  1.00 29.99  ? 67  SER M C   1 
ATOM   3723 O  O   . SER D 1 68  ? 1.068   -34.370 26.194  1.00 31.28  ? 67  SER M O   1 
ATOM   3724 C  CB  . SER D 1 68  ? 0.131   -31.231 26.561  1.00 41.71  ? 67  SER M CB  1 
ATOM   3725 O  OG  . SER D 1 68  ? -0.879  -31.335 27.558  1.00 43.95  ? 67  SER M OG  1 
ATOM   3726 N  N   . GLY D 1 69  ? 0.565   -33.885 28.318  1.00 24.76  ? 68  GLY M N   1 
ATOM   3727 C  CA  . GLY D 1 69  ? 0.120   -35.240 28.575  1.00 24.38  ? 68  GLY M CA  1 
ATOM   3728 C  C   . GLY D 1 69  ? 1.274   -36.228 28.599  1.00 26.98  ? 68  GLY M C   1 
ATOM   3729 O  O   . GLY D 1 69  ? 2.027   -36.271 29.574  1.00 25.01  ? 68  GLY M O   1 
ATOM   3730 N  N   . THR D 1 70  ? 1.413   -37.016 27.532  1.00 25.06  ? 69  THR M N   1 
ATOM   3731 C  CA  . THR D 1 70  ? 2.464   -38.021 27.438  1.00 23.25  ? 69  THR M CA  1 
ATOM   3732 C  C   . THR D 1 70  ? 3.468   -37.785 26.306  1.00 23.52  ? 69  THR M C   1 
ATOM   3733 O  O   . THR D 1 70  ? 4.388   -38.573 26.149  1.00 26.43  ? 69  THR M O   1 
ATOM   3734 C  CB  . THR D 1 70  ? 1.889   -39.452 27.239  1.00 24.38  ? 69  THR M CB  1 
ATOM   3735 O  OG1 . THR D 1 70  ? 1.226   -39.521 25.972  1.00 29.84  ? 69  THR M OG1 1 
ATOM   3736 C  CG2 . THR D 1 70  ? 0.921   -39.814 28.352  1.00 22.69  ? 69  THR M CG2 1 
ATOM   3737 N  N   . GLN D 1 71  ? 3.291   -36.725 25.519  1.00 22.95  ? 70  GLN M N   1 
ATOM   3738 C  CA  . GLN D 1 71  ? 4.126   -36.509 24.330  1.00 24.55  ? 70  GLN M CA  1 
ATOM   3739 C  C   . GLN D 1 71  ? 4.761   -35.125 24.311  1.00 23.18  ? 70  GLN M C   1 
ATOM   3740 O  O   . GLN D 1 71  ? 4.064   -34.116 24.325  1.00 24.07  ? 70  GLN M O   1 
ATOM   3741 C  CB  . GLN D 1 71  ? 3.294   -36.746 23.058  1.00 29.89  ? 70  GLN M CB  1 
ATOM   3742 C  CG  . GLN D 1 71  ? 2.694   -38.157 23.000  1.00 36.64  ? 70  GLN M CG  1 
ATOM   3743 C  CD  . GLN D 1 71  ? 1.492   -38.283 22.065  1.00 62.16  ? 70  GLN M CD  1 
ATOM   3744 O  OE1 . GLN D 1 71  ? 1.631   -38.727 20.922  1.00 60.05  ? 70  GLN M OE1 1 
ATOM   3745 N  NE2 . GLN D 1 71  ? 0.302   -37.911 22.557  1.00 50.38  ? 70  GLN M NE2 1 
ATOM   3746 N  N   . PHE D 1 72  ? 6.091   -35.073 24.289  1.00 24.09  ? 71  PHE M N   1 
ATOM   3747 C  CA  . PHE D 1 72  ? 6.816   -33.809 24.398  1.00 20.16  ? 71  PHE M CA  1 
ATOM   3748 C  C   . PHE D 1 72  ? 7.985   -33.733 23.406  1.00 21.80  ? 71  PHE M C   1 
ATOM   3749 O  O   . PHE D 1 72  ? 8.586   -34.755 23.067  1.00 20.28  ? 71  PHE M O   1 
ATOM   3750 C  CB  . PHE D 1 72  ? 7.345   -33.621 25.827  1.00 21.12  ? 71  PHE M CB  1 
ATOM   3751 C  CG  . PHE D 1 72  ? 6.282   -33.718 26.880  1.00 24.89  ? 71  PHE M CG  1 
ATOM   3752 C  CD1 . PHE D 1 72  ? 5.922   -34.948 27.415  1.00 19.52  ? 71  PHE M CD1 1 
ATOM   3753 C  CD2 . PHE D 1 72  ? 5.635   -32.581 27.332  1.00 22.21  ? 71  PHE M CD2 1 
ATOM   3754 C  CE1 . PHE D 1 72  ? 4.936   -35.036 28.377  1.00 25.33  ? 71  PHE M CE1 1 
ATOM   3755 C  CE2 . PHE D 1 72  ? 4.645   -32.665 28.298  1.00 23.85  ? 71  PHE M CE2 1 
ATOM   3756 C  CZ  . PHE D 1 72  ? 4.295   -33.890 28.818  1.00 20.48  ? 71  PHE M CZ  1 
ATOM   3757 N  N   . THR D 1 73  ? 8.284   -32.532 22.919  1.00 17.47  ? 72  THR M N   1 
ATOM   3758 C  CA  . THR D 1 73  ? 9.429   -32.332 22.032  1.00 22.24  ? 72  THR M CA  1 
ATOM   3759 C  C   . THR D 1 73  ? 10.213  -31.116 22.473  1.00 22.53  ? 72  THR M C   1 
ATOM   3760 O  O   . THR D 1 73  ? 9.672   -30.213 23.118  1.00 24.02  ? 72  THR M O   1 
ATOM   3761 C  CB  . THR D 1 73  ? 9.009   -32.119 20.553  1.00 28.90  ? 72  THR M CB  1 
ATOM   3762 O  OG1 . THR D 1 73  ? 8.293   -30.890 20.443  1.00 23.72  ? 72  THR M OG1 1 
ATOM   3763 C  CG2 . THR D 1 73  ? 8.134   -33.276 20.053  1.00 25.70  ? 72  THR M CG2 1 
ATOM   3764 N  N   . PHE D 1 74  ? 11.490  -31.101 22.119  1.00 20.62  ? 73  PHE M N   1 
ATOM   3765 C  CA  . PHE D 1 74  ? 12.418  -30.029 22.474  1.00 19.67  ? 73  PHE M CA  1 
ATOM   3766 C  C   . PHE D 1 74  ? 13.218  -29.682 21.217  1.00 24.46  ? 73  PHE M C   1 
ATOM   3767 O  O   . PHE D 1 74  ? 13.767  -30.576 20.562  1.00 22.09  ? 73  PHE M O   1 
ATOM   3768 C  CB  . PHE D 1 74  ? 13.338  -30.509 23.597  1.00 17.77  ? 73  PHE M CB  1 
ATOM   3769 C  CG  . PHE D 1 74  ? 14.522  -29.627 23.855  1.00 18.14  ? 73  PHE M CG  1 
ATOM   3770 C  CD1 . PHE D 1 74  ? 14.402  -28.483 24.646  1.00 16.94  ? 73  PHE M CD1 1 
ATOM   3771 C  CD2 . PHE D 1 74  ? 15.771  -29.956 23.343  1.00 23.68  ? 73  PHE M CD2 1 
ATOM   3772 C  CE1 . PHE D 1 74  ? 15.487  -27.679 24.899  1.00 21.19  ? 73  PHE M CE1 1 
ATOM   3773 C  CE2 . PHE D 1 74  ? 16.874  -29.155 23.605  1.00 15.66  ? 73  PHE M CE2 1 
ATOM   3774 C  CZ  . PHE D 1 74  ? 16.727  -28.014 24.373  1.00 15.33  ? 73  PHE M CZ  1 
ATOM   3775 N  N   . THR D 1 75  ? 13.273  -28.401 20.867  1.00 16.97  ? 74  THR M N   1 
ATOM   3776 C  CA  . THR D 1 75  ? 13.921  -27.981 19.618  1.00 17.05  ? 74  THR M CA  1 
ATOM   3777 C  C   . THR D 1 75  ? 14.929  -26.853 19.850  1.00 21.63  ? 74  THR M C   1 
ATOM   3778 O  O   . THR D 1 75  ? 14.614  -25.823 20.459  1.00 20.73  ? 74  THR M O   1 
ATOM   3779 C  CB  . THR D 1 75  ? 12.876  -27.535 18.544  1.00 22.78  ? 74  THR M CB  1 
ATOM   3780 O  OG1 . THR D 1 75  ? 12.128  -28.672 18.088  1.00 17.69  ? 74  THR M OG1 1 
ATOM   3781 C  CG2 . THR D 1 75  ? 13.561  -26.864 17.330  1.00 17.00  ? 74  THR M CG2 1 
ATOM   3782 N  N   . ILE D 1 76  ? 16.146  -27.055 19.364  1.00 19.89  ? 75  ILE M N   1 
ATOM   3783 C  CA  . ILE D 1 76  ? 17.141  -25.990 19.349  1.00 20.52  ? 75  ILE M CA  1 
ATOM   3784 C  C   . ILE D 1 76  ? 17.164  -25.362 17.956  1.00 20.38  ? 75  ILE M C   1 
ATOM   3785 O  O   . ILE D 1 76  ? 17.384  -26.056 16.972  1.00 16.42  ? 75  ILE M O   1 
ATOM   3786 C  CB  . ILE D 1 76  ? 18.552  -26.519 19.667  1.00 19.65  ? 75  ILE M CB  1 
ATOM   3787 C  CG1 . ILE D 1 76  ? 18.561  -27.278 20.998  1.00 25.11  ? 75  ILE M CG1 1 
ATOM   3788 C  CG2 . ILE D 1 76  ? 19.554  -25.368 19.677  1.00 19.60  ? 75  ILE M CG2 1 
ATOM   3789 C  CD1 . ILE D 1 76  ? 19.939  -27.888 21.320  1.00 25.26  ? 75  ILE M CD1 1 
ATOM   3790 N  N   . SER D 1 77  ? 16.906  -24.056 17.885  1.00 18.25  ? 76  SER M N   1 
ATOM   3791 C  CA  . SER D 1 77  ? 17.056  -23.283 16.647  1.00 23.84  ? 76  SER M CA  1 
ATOM   3792 C  C   . SER D 1 77  ? 18.461  -22.712 16.526  1.00 25.15  ? 76  SER M C   1 
ATOM   3793 O  O   . SER D 1 77  ? 19.086  -22.371 17.538  1.00 22.15  ? 76  SER M O   1 
ATOM   3794 C  CB  . SER D 1 77  ? 16.057  -22.111 16.621  1.00 24.69  ? 76  SER M CB  1 
ATOM   3795 O  OG  . SER D 1 77  ? 14.741  -22.590 16.430  1.00 28.98  ? 76  SER M OG  1 
ATOM   3796 N  N   . ASP D 1 78  ? 18.928  -22.583 15.283  1.00 25.08  ? 77  ASP M N   1 
ATOM   3797 C  CA  . ASP D 1 78  ? 20.225  -21.982 14.974  1.00 25.48  ? 77  ASP M CA  1 
ATOM   3798 C  C   . ASP D 1 78  ? 21.333  -22.578 15.866  1.00 22.39  ? 77  ASP M C   1 
ATOM   3799 O  O   . ASP D 1 78  ? 21.961  -21.865 16.642  1.00 19.25  ? 77  ASP M O   1 
ATOM   3800 C  CB  . ASP D 1 78  ? 20.140  -20.453 15.124  1.00 23.45  ? 77  ASP M CB  1 
ATOM   3801 C  CG  . ASP D 1 78  ? 21.372  -19.739 14.595  1.00 30.07  ? 77  ASP M CG  1 
ATOM   3802 O  OD1 . ASP D 1 78  ? 21.569  -18.557 14.950  1.00 39.08  ? 77  ASP M OD1 1 
ATOM   3803 O  OD2 . ASP D 1 78  ? 22.150  -20.355 13.833  1.00 33.10  ? 77  ASP M OD2 1 
ATOM   3804 N  N   . VAL D 1 79  ? 21.527  -23.892 15.745  1.00 20.80  ? 78  VAL M N   1 
ATOM   3805 C  CA  . VAL D 1 79  ? 22.443  -24.658 16.585  1.00 16.28  ? 78  VAL M CA  1 
ATOM   3806 C  C   . VAL D 1 79  ? 23.867  -24.098 16.529  1.00 16.90  ? 78  VAL M C   1 
ATOM   3807 O  O   . VAL D 1 79  ? 24.369  -23.769 15.452  1.00 19.78  ? 78  VAL M O   1 
ATOM   3808 C  CB  . VAL D 1 79  ? 22.478  -26.149 16.130  1.00 17.14  ? 78  VAL M CB  1 
ATOM   3809 C  CG1 . VAL D 1 79  ? 23.653  -26.908 16.778  1.00 14.76  ? 78  VAL M CG1 1 
ATOM   3810 C  CG2 . VAL D 1 79  ? 21.164  -26.806 16.408  1.00 15.70  ? 78  VAL M CG2 1 
ATOM   3811 N  N   . GLN D 1 80  ? 24.504  -23.995 17.690  1.00 16.95  ? 79  GLN M N   1 
ATOM   3812 C  CA  . GLN D 1 80  ? 25.862  -23.457 17.796  1.00 18.66  ? 79  GLN M CA  1 
ATOM   3813 C  C   . GLN D 1 80  ? 26.814  -24.496 18.367  1.00 22.58  ? 79  GLN M C   1 
ATOM   3814 O  O   . GLN D 1 80  ? 26.386  -25.434 19.039  1.00 20.15  ? 79  GLN M O   1 
ATOM   3815 C  CB  . GLN D 1 80  ? 25.876  -22.226 18.720  1.00 22.28  ? 79  GLN M CB  1 
ATOM   3816 C  CG  . GLN D 1 80  ? 25.079  -21.035 18.196  1.00 28.83  ? 79  GLN M CG  1 
ATOM   3817 C  CD  . GLN D 1 80  ? 25.485  -20.634 16.787  1.00 29.82  ? 79  GLN M CD  1 
ATOM   3818 O  OE1 . GLN D 1 80  ? 26.659  -20.367 16.523  1.00 37.67  ? 79  GLN M OE1 1 
ATOM   3819 N  NE2 . GLN D 1 80  ? 24.515  -20.620 15.864  1.00 29.42  ? 79  GLN M NE2 1 
ATOM   3820 N  N   . CYS D 1 81  ? 28.111  -24.320 18.128  1.00 18.90  ? 80  CYS M N   1 
ATOM   3821 C  CA  . CYS D 1 81  ? 29.094  -25.232 18.712  1.00 22.12  ? 80  CYS M CA  1 
ATOM   3822 C  C   . CYS D 1 81  ? 28.937  -25.334 20.234  1.00 20.13  ? 80  CYS M C   1 
ATOM   3823 O  O   . CYS D 1 81  ? 29.116  -26.402 20.809  1.00 19.12  ? 80  CYS M O   1 
ATOM   3824 C  CB  . CYS D 1 81  ? 30.515  -24.805 18.338  1.00 19.14  ? 80  CYS M CB  1 
ATOM   3825 S  SG  . CYS D 1 81  ? 30.820  -24.948 16.582  1.00 23.88  ? 80  CYS M SG  1 
ATOM   3826 N  N   . ASP D 1 82  ? 28.566  -24.226 20.876  1.00 21.83  ? 81  ASP M N   1 
ATOM   3827 C  CA  . ASP D 1 82  ? 28.368  -24.202 22.332  1.00 23.20  ? 81  ASP M CA  1 
ATOM   3828 C  C   . ASP D 1 82  ? 27.241  -25.127 22.808  1.00 24.81  ? 81  ASP M C   1 
ATOM   3829 O  O   . ASP D 1 82  ? 27.160  -25.467 23.995  1.00 22.25  ? 81  ASP M O   1 
ATOM   3830 C  CB  . ASP D 1 82  ? 28.098  -22.769 22.819  1.00 24.94  ? 81  ASP M CB  1 
ATOM   3831 C  CG  . ASP D 1 82  ? 28.162  -22.643 24.340  1.00 34.62  ? 81  ASP M CG  1 
ATOM   3832 O  OD1 . ASP D 1 82  ? 27.179  -22.166 24.946  1.00 40.06  ? 81  ASP M OD1 1 
ATOM   3833 O  OD2 . ASP D 1 82  ? 29.185  -23.033 24.937  1.00 25.63  ? 81  ASP M OD2 1 
ATOM   3834 N  N   . ASP D 1 83  ? 26.371  -25.549 21.891  1.00 21.83  ? 82  ASP M N   1 
ATOM   3835 C  CA  . ASP D 1 83  ? 25.235  -26.392 22.269  1.00 22.22  ? 82  ASP M CA  1 
ATOM   3836 C  C   . ASP D 1 83  ? 25.590  -27.877 22.392  1.00 21.82  ? 82  ASP M C   1 
ATOM   3837 O  O   . ASP D 1 83  ? 24.797  -28.648 22.941  1.00 20.20  ? 82  ASP M O   1 
ATOM   3838 C  CB  . ASP D 1 83  ? 24.082  -26.265 21.263  1.00 20.25  ? 82  ASP M CB  1 
ATOM   3839 C  CG  . ASP D 1 83  ? 23.555  -24.845 21.142  1.00 24.18  ? 82  ASP M CG  1 
ATOM   3840 O  OD1 . ASP D 1 83  ? 23.633  -24.088 22.135  1.00 22.86  ? 82  ASP M OD1 1 
ATOM   3841 O  OD2 . ASP D 1 83  ? 23.051  -24.492 20.051  1.00 20.12  ? 82  ASP M OD2 1 
ATOM   3842 N  N   . ALA D 1 84  ? 26.743  -28.273 21.850  1.00 16.18  ? 83  ALA M N   1 
ATOM   3843 C  CA  . ALA D 1 84  ? 27.153  -29.682 21.852  1.00 21.84  ? 83  ALA M CA  1 
ATOM   3844 C  C   . ALA D 1 84  ? 27.207  -30.213 23.291  1.00 25.00  ? 83  ALA M C   1 
ATOM   3845 O  O   . ALA D 1 84  ? 28.013  -29.757 24.100  1.00 22.08  ? 83  ALA M O   1 
ATOM   3846 C  CB  . ALA D 1 84  ? 28.518  -29.862 21.149  1.00 16.85  ? 83  ALA M CB  1 
ATOM   3847 N  N   . ALA D 1 85  ? 26.323  -31.157 23.600  1.00 22.07  ? 84  ALA M N   1 
ATOM   3848 C  CA  . ALA D 1 85  ? 26.147  -31.648 24.966  1.00 23.47  ? 84  ALA M CA  1 
ATOM   3849 C  C   . ALA D 1 85  ? 25.232  -32.855 24.953  1.00 21.02  ? 84  ALA M C   1 
ATOM   3850 O  O   . ALA D 1 85  ? 24.812  -33.312 23.888  1.00 17.61  ? 84  ALA M O   1 
ATOM   3851 C  CB  . ALA D 1 85  ? 25.535  -30.550 25.864  1.00 15.14  ? 84  ALA M CB  1 
ATOM   3852 N  N   . THR D 1 86  ? 24.930  -33.368 26.141  1.00 14.00  ? 85  THR M N   1 
ATOM   3853 C  CA  . THR D 1 86  ? 23.858  -34.338 26.308  1.00 16.50  ? 85  THR M CA  1 
ATOM   3854 C  C   . THR D 1 86  ? 22.648  -33.638 26.931  1.00 16.96  ? 85  THR M C   1 
ATOM   3855 O  O   . THR D 1 86  ? 22.782  -32.896 27.910  1.00 17.79  ? 85  THR M O   1 
ATOM   3856 C  CB  . THR D 1 86  ? 24.292  -35.496 27.225  1.00 21.25  ? 85  THR M CB  1 
ATOM   3857 O  OG1 . THR D 1 86  ? 25.492  -36.087 26.715  1.00 22.19  ? 85  THR M OG1 1 
ATOM   3858 C  CG2 . THR D 1 86  ? 23.212  -36.550 27.301  1.00 19.55  ? 85  THR M CG2 1 
ATOM   3859 N  N   . PHE D 1 87  ? 21.470  -33.882 26.361  1.00 16.65  ? 86  PHE M N   1 
ATOM   3860 C  CA  . PHE D 1 87  ? 20.233  -33.283 26.861  1.00 15.99  ? 86  PHE M CA  1 
ATOM   3861 C  C   . PHE D 1 87  ? 19.324  -34.345 27.467  1.00 15.04  ? 86  PHE M C   1 
ATOM   3862 O  O   . PHE D 1 87  ? 19.294  -35.473 26.978  1.00 16.52  ? 86  PHE M O   1 
ATOM   3863 C  CB  . PHE D 1 87  ? 19.508  -32.563 25.722  1.00 17.69  ? 86  PHE M CB  1 
ATOM   3864 C  CG  . PHE D 1 87  ? 20.281  -31.390 25.175  1.00 17.87  ? 86  PHE M CG  1 
ATOM   3865 C  CD1 . PHE D 1 87  ? 21.343  -31.593 24.300  1.00 14.84  ? 86  PHE M CD1 1 
ATOM   3866 C  CD2 . PHE D 1 87  ? 19.973  -30.100 25.558  1.00 15.46  ? 86  PHE M CD2 1 
ATOM   3867 C  CE1 . PHE D 1 87  ? 22.055  -30.521 23.801  1.00 16.14  ? 86  PHE M CE1 1 
ATOM   3868 C  CE2 . PHE D 1 87  ? 20.690  -29.023 25.070  1.00 16.09  ? 86  PHE M CE2 1 
ATOM   3869 C  CZ  . PHE D 1 87  ? 21.737  -29.236 24.193  1.00 15.16  ? 86  PHE M CZ  1 
ATOM   3870 N  N   . TYR D 1 88  ? 18.588  -33.974 28.514  1.00 13.10  ? 87  TYR M N   1 
ATOM   3871 C  CA  . TYR D 1 88  ? 17.681  -34.891 29.206  1.00 16.45  ? 87  TYR M CA  1 
ATOM   3872 C  C   . TYR D 1 88  ? 16.305  -34.268 29.436  1.00 17.13  ? 87  TYR M C   1 
ATOM   3873 O  O   . TYR D 1 88  ? 16.199  -33.084 29.776  1.00 17.43  ? 87  TYR M O   1 
ATOM   3874 C  CB  . TYR D 1 88  ? 18.236  -35.250 30.589  1.00 18.51  ? 87  TYR M CB  1 
ATOM   3875 C  CG  . TYR D 1 88  ? 19.535  -36.018 30.599  1.00 15.29  ? 87  TYR M CG  1 
ATOM   3876 C  CD1 . TYR D 1 88  ? 19.538  -37.405 30.581  1.00 15.29  ? 87  TYR M CD1 1 
ATOM   3877 C  CD2 . TYR D 1 88  ? 20.752  -35.363 30.660  1.00 16.74  ? 87  TYR M CD2 1 
ATOM   3878 C  CE1 . TYR D 1 88  ? 20.713  -38.125 30.592  1.00 16.02  ? 87  TYR M CE1 1 
ATOM   3879 C  CE2 . TYR D 1 88  ? 21.939  -36.072 30.690  1.00 20.44  ? 87  TYR M CE2 1 
ATOM   3880 C  CZ  . TYR D 1 88  ? 21.910  -37.462 30.643  1.00 19.20  ? 87  TYR M CZ  1 
ATOM   3881 O  OH  . TYR D 1 88  ? 23.082  -38.183 30.669  1.00 18.07  ? 87  TYR M OH  1 
ATOM   3882 N  N   . CYS D 1 89  ? 15.260  -35.076 29.302  1.00 17.90  ? 88  CYS M N   1 
ATOM   3883 C  CA  . CYS D 1 89  ? 13.940  -34.703 29.797  1.00 17.28  ? 88  CYS M CA  1 
ATOM   3884 C  C   . CYS D 1 89  ? 13.687  -35.313 31.186  1.00 15.40  ? 88  CYS M C   1 
ATOM   3885 O  O   . CYS D 1 89  ? 14.215  -36.386 31.510  1.00 17.23  ? 88  CYS M O   1 
ATOM   3886 C  CB  . CYS D 1 89  ? 12.852  -35.123 28.795  1.00 13.01  ? 88  CYS M CB  1 
ATOM   3887 S  SG  . CYS D 1 89  ? 12.749  -36.914 28.580  1.00 21.71  ? 88  CYS M SG  1 
ATOM   3888 N  N   . LEU D 1 90  ? 12.898  -34.626 32.012  1.00 15.18  ? 89  LEU M N   1 
ATOM   3889 C  CA  . LEU D 1 90  ? 12.547  -35.124 33.337  1.00 17.47  ? 89  LEU M CA  1 
ATOM   3890 C  C   . LEU D 1 90  ? 11.049  -34.953 33.585  1.00 18.29  ? 89  LEU M C   1 
ATOM   3891 O  O   . LEU D 1 90  ? 10.535  -33.849 33.500  1.00 18.25  ? 89  LEU M O   1 
ATOM   3892 C  CB  . LEU D 1 90  ? 13.307  -34.364 34.437  1.00 13.83  ? 89  LEU M CB  1 
ATOM   3893 C  CG  . LEU D 1 90  ? 12.775  -34.480 35.877  1.00 18.59  ? 89  LEU M CG  1 
ATOM   3894 C  CD1 . LEU D 1 90  ? 13.068  -35.875 36.456  1.00 17.64  ? 89  LEU M CD1 1 
ATOM   3895 C  CD2 . LEU D 1 90  ? 13.315  -33.372 36.811  1.00 15.47  ? 89  LEU M CD2 1 
ATOM   3896 N  N   . GLY D 1 91  ? 10.369  -36.043 33.926  1.00 15.81  ? 90  GLY M N   1 
ATOM   3897 C  CA  . GLY D 1 91  ? 8.941   -35.993 34.233  1.00 14.90  ? 90  GLY M CA  1 
ATOM   3898 C  C   . GLY D 1 91  ? 8.633   -35.990 35.722  1.00 21.41  ? 90  GLY M C   1 
ATOM   3899 O  O   . GLY D 1 91  ? 9.272   -36.720 36.489  1.00 17.01  ? 90  GLY M O   1 
ATOM   3900 N  N   . GLY D 1 92  ? 7.676   -35.148 36.130  1.00 20.45  ? 91  GLY M N   1 
ATOM   3901 C  CA  . GLY D 1 92  ? 7.112   -35.168 37.473  1.00 21.04  ? 91  GLY M CA  1 
ATOM   3902 C  C   . GLY D 1 92  ? 5.735   -35.817 37.417  1.00 21.58  ? 91  GLY M C   1 
ATOM   3903 O  O   . GLY D 1 92  ? 4.937   -35.499 36.532  1.00 20.79  ? 91  GLY M O   1 
ATOM   3904 N  N   . TYR D 1 93  ? 5.462   -36.739 38.340  1.00 21.19  ? 92  TYR M N   1 
ATOM   3905 C  CA  . TYR D 1 93  ? 4.261   -37.581 38.265  1.00 17.57  ? 92  TYR M CA  1 
ATOM   3906 C  C   . TYR D 1 93  ? 3.384   -37.492 39.511  1.00 24.14  ? 92  TYR M C   1 
ATOM   3907 O  O   . TYR D 1 93  ? 3.801   -36.945 40.528  1.00 20.64  ? 92  TYR M O   1 
ATOM   3908 C  CB  . TYR D 1 93  ? 4.652   -39.041 37.997  1.00 18.31  ? 92  TYR M CB  1 
ATOM   3909 C  CG  . TYR D 1 93  ? 5.307   -39.210 36.647  1.00 21.48  ? 92  TYR M CG  1 
ATOM   3910 C  CD1 . TYR D 1 93  ? 4.533   -39.370 35.501  1.00 23.05  ? 92  TYR M CD1 1 
ATOM   3911 C  CD2 . TYR D 1 93  ? 6.698   -39.156 36.509  1.00 17.28  ? 92  TYR M CD2 1 
ATOM   3912 C  CE1 . TYR D 1 93  ? 5.118   -39.495 34.254  1.00 20.10  ? 92  TYR M CE1 1 
ATOM   3913 C  CE2 . TYR D 1 93  ? 7.298   -39.283 35.258  1.00 16.74  ? 92  TYR M CE2 1 
ATOM   3914 C  CZ  . TYR D 1 93  ? 6.495   -39.452 34.137  1.00 22.04  ? 92  TYR M CZ  1 
ATOM   3915 O  OH  . TYR D 1 93  ? 7.063   -39.576 32.889  1.00 19.20  ? 92  TYR M OH  1 
ATOM   3916 N  N   . ASP D 1 94  ? 2.170   -38.035 39.435  1.00 19.19  ? 93  ASP M N   1 
ATOM   3917 C  CA  . ASP D 1 94  ? 1.309   -38.103 40.619  1.00 23.82  ? 93  ASP M CA  1 
ATOM   3918 C  C   . ASP D 1 94  ? 1.883   -39.095 41.648  1.00 20.40  ? 93  ASP M C   1 
ATOM   3919 O  O   . ASP D 1 94  ? 1.894   -40.304 41.400  1.00 22.52  ? 93  ASP M O   1 
ATOM   3920 C  CB  . ASP D 1 94  ? -0.110  -38.523 40.203  1.00 25.74  ? 93  ASP M CB  1 
ATOM   3921 C  CG  . ASP D 1 94  ? -1.114  -38.402 41.337  1.00 38.23  ? 93  ASP M CG  1 
ATOM   3922 O  OD1 . ASP D 1 94  ? -0.814  -38.814 42.484  1.00 29.11  ? 93  ASP M OD1 1 
ATOM   3923 O  OD2 . ASP D 1 94  ? -2.216  -37.881 41.073  1.00 43.19  ? 93  ASP M OD2 1 
ATOM   3924 N  N   . CYS D 1 95  ? 2.345   -38.595 42.796  1.00 19.05  ? 94  CYS M N   1 
ATOM   3925 C  CA  . CYS D 1 95  ? 2.982   -39.452 43.807  1.00 22.70  ? 94  CYS M CA  1 
ATOM   3926 C  C   . CYS D 1 95  ? 2.086   -40.567 44.360  1.00 30.49  ? 94  CYS M C   1 
ATOM   3927 O  O   . CYS D 1 95  ? 2.588   -41.564 44.885  1.00 22.96  ? 94  CYS M O   1 
ATOM   3928 C  CB  . CYS D 1 95  ? 3.497   -38.626 44.995  1.00 23.21  ? 94  CYS M CB  1 
ATOM   3929 S  SG  . CYS D 1 95  ? 4.844   -37.505 44.620  1.00 32.44  ? 94  CYS M SG  1 
ATOM   3930 N  N   . SER D 1 96  ? 0.768   -40.396 44.258  1.00 26.24  ? 95  SER M N   1 
ATOM   3931 C  CA  . SER D 1 96  ? -0.165  -41.356 44.840  1.00 29.85  ? 95  SER M CA  1 
ATOM   3932 C  C   . SER D 1 96  ? -0.413  -42.573 43.947  1.00 34.42  ? 95  SER M C   1 
ATOM   3933 O  O   . SER D 1 96  ? -1.027  -43.543 44.378  1.00 35.88  ? 95  SER M O   1 
ATOM   3934 C  CB  . SER D 1 96  ? -1.498  -40.679 45.198  1.00 26.50  ? 95  SER M CB  1 
ATOM   3935 O  OG  . SER D 1 96  ? -2.194  -40.258 44.035  1.00 28.96  ? 95  SER M OG  1 
ATOM   3936 N  N   . SER D 1 97  A 0.068   -42.538 42.710  1.00 28.96  ? 95  SER M N   1 
ATOM   3937 C  CA  . SER D 1 97  A -0.181  -43.653 41.805  1.00 28.72  ? 95  SER M CA  1 
ATOM   3938 C  C   . SER D 1 97  A 1.089   -44.292 41.265  1.00 32.29  ? 95  SER M C   1 
ATOM   3939 O  O   . SER D 1 97  A 1.030   -45.147 40.388  1.00 31.62  ? 95  SER M O   1 
ATOM   3940 C  CB  . SER D 1 97  A -1.063  -43.204 40.643  1.00 33.69  ? 95  SER M CB  1 
ATOM   3941 O  OG  . SER D 1 97  A -0.380  -42.276 39.820  1.00 38.06  ? 95  SER M OG  1 
ATOM   3942 N  N   . GLY D 1 98  B 2.237   -43.871 41.778  1.00 25.51  ? 95  GLY M N   1 
ATOM   3943 C  CA  . GLY D 1 98  B 3.507   -44.409 41.324  1.00 27.18  ? 95  GLY M CA  1 
ATOM   3944 C  C   . GLY D 1 98  B 4.631   -43.558 41.883  1.00 25.69  ? 95  GLY M C   1 
ATOM   3945 O  O   . GLY D 1 98  B 4.412   -42.862 42.871  1.00 21.53  ? 95  GLY M O   1 
ATOM   3946 N  N   . ASP D 1 99  C 5.811   -43.617 41.254  1.00 23.01  ? 95  ASP M N   1 
ATOM   3947 C  CA  . ASP D 1 99  C 6.975   -42.832 41.668  1.00 22.24  ? 95  ASP M CA  1 
ATOM   3948 C  C   . ASP D 1 99  C 6.749   -41.359 41.310  1.00 23.23  ? 95  ASP M C   1 
ATOM   3949 O  O   . ASP D 1 99  C 6.013   -41.049 40.365  1.00 20.69  ? 95  ASP M O   1 
ATOM   3950 C  CB  . ASP D 1 99  C 8.251   -43.349 40.988  1.00 20.88  ? 95  ASP M CB  1 
ATOM   3951 C  CG  . ASP D 1 99  C 8.872   -44.549 41.713  1.00 26.57  ? 95  ASP M CG  1 
ATOM   3952 O  OD1 . ASP D 1 99  C 8.185   -45.174 42.544  1.00 23.63  ? 95  ASP M OD1 1 
ATOM   3953 O  OD2 . ASP D 1 99  C 10.057  -44.875 41.447  1.00 19.57  ? 95  ASP M OD2 1 
ATOM   3954 N  N   . CYS D 1 100 D 7.362   -40.460 42.074  1.00 16.62  ? 95  CYS M N   1 
ATOM   3955 C  CA  . CYS D 1 100 D 7.165   -39.026 41.878  1.00 19.15  ? 95  CYS M CA  1 
ATOM   3956 C  C   . CYS D 1 100 D 7.847   -38.453 40.629  1.00 18.51  ? 95  CYS M C   1 
ATOM   3957 O  O   . CYS D 1 100 D 7.489   -37.363 40.187  1.00 15.77  ? 95  CYS M O   1 
ATOM   3958 C  CB  . CYS D 1 100 D 7.641   -38.237 43.101  1.00 20.62  ? 95  CYS M CB  1 
ATOM   3959 S  SG  . CYS D 1 100 D 6.644   -38.473 44.600  1.00 26.94  ? 95  CYS M SG  1 
ATOM   3960 N  N   . ALA D 1 101 ? 8.824   -39.169 40.076  1.00 18.24  ? 96  ALA M N   1 
ATOM   3961 C  CA  . ALA D 1 101 ? 9.643   -38.612 38.992  1.00 20.32  ? 96  ALA M CA  1 
ATOM   3962 C  C   . ALA D 1 101 ? 10.365  -39.690 38.169  1.00 17.72  ? 96  ALA M C   1 
ATOM   3963 O  O   . ALA D 1 101 ? 10.540  -40.807 38.640  1.00 18.58  ? 96  ALA M O   1 
ATOM   3964 C  CB  . ALA D 1 101 ? 10.644  -37.615 39.554  1.00 18.60  ? 96  ALA M CB  1 
ATOM   3965 N  N   . ALA D 1 102 ? 10.768  -39.340 36.945  1.00 15.35  ? 97  ALA M N   1 
ATOM   3966 C  CA  . ALA D 1 102 ? 11.579  -40.210 36.085  1.00 15.74  ? 97  ALA M CA  1 
ATOM   3967 C  C   . ALA D 1 102 ? 12.326  -39.370 35.058  1.00 20.47  ? 97  ALA M C   1 
ATOM   3968 O  O   . ALA D 1 102 ? 11.745  -38.468 34.464  1.00 18.05  ? 97  ALA M O   1 
ATOM   3969 C  CB  . ALA D 1 102 ? 10.691  -41.234 35.348  1.00 13.84  ? 97  ALA M CB  1 
ATOM   3970 N  N   . PHE D 1 103 ? 13.606  -39.673 34.849  1.00 20.58  ? 98  PHE M N   1 
ATOM   3971 C  CA  . PHE D 1 103 ? 14.406  -39.062 33.783  1.00 19.86  ? 98  PHE M CA  1 
ATOM   3972 C  C   . PHE D 1 103 ? 14.319  -39.885 32.493  1.00 14.88  ? 98  PHE M C   1 
ATOM   3973 O  O   . PHE D 1 103 ? 14.187  -41.093 32.554  1.00 13.12  ? 98  PHE M O   1 
ATOM   3974 C  CB  . PHE D 1 103 ? 15.884  -39.002 34.205  1.00 13.88  ? 98  PHE M CB  1 
ATOM   3975 C  CG  . PHE D 1 103 ? 16.213  -37.845 35.106  1.00 14.07  ? 98  PHE M CG  1 
ATOM   3976 C  CD1 . PHE D 1 103 ? 16.371  -36.566 34.585  1.00 13.96  ? 98  PHE M CD1 1 
ATOM   3977 C  CD2 . PHE D 1 103 ? 16.368  -38.038 36.469  1.00 13.13  ? 98  PHE M CD2 1 
ATOM   3978 C  CE1 . PHE D 1 103 ? 16.685  -35.498 35.413  1.00 14.11  ? 98  PHE M CE1 1 
ATOM   3979 C  CE2 . PHE D 1 103 ? 16.668  -36.965 37.316  1.00 16.36  ? 98  PHE M CE2 1 
ATOM   3980 C  CZ  . PHE D 1 103 ? 16.836  -35.701 36.793  1.00 11.83  ? 98  PHE M CZ  1 
ATOM   3981 N  N   . GLY D 1 104 ? 14.394  -39.232 31.334  1.00 21.02  ? 99  GLY M N   1 
ATOM   3982 C  CA  . GLY D 1 104 ? 14.610  -39.946 30.077  1.00 19.11  ? 99  GLY M CA  1 
ATOM   3983 C  C   . GLY D 1 104 ? 16.078  -40.358 30.004  1.00 19.09  ? 99  GLY M C   1 
ATOM   3984 O  O   . GLY D 1 104 ? 16.871  -39.904 30.812  1.00 16.00  ? 99  GLY M O   1 
ATOM   3985 N  N   . GLY D 1 105 ? 16.446  -41.195 29.040  1.00 13.62  ? 100 GLY M N   1 
ATOM   3986 C  CA  . GLY D 1 105 ? 17.796  -41.733 28.988  1.00 20.71  ? 100 GLY M CA  1 
ATOM   3987 C  C   . GLY D 1 105 ? 18.847  -40.836 28.350  1.00 21.39  ? 100 GLY M C   1 
ATOM   3988 O  O   . GLY D 1 105 ? 20.025  -41.192 28.328  1.00 20.75  ? 100 GLY M O   1 
ATOM   3989 N  N   . GLY D 1 106 ? 18.432  -39.686 27.814  1.00 15.33  ? 101 GLY M N   1 
ATOM   3990 C  CA  . GLY D 1 106 ? 19.374  -38.730 27.253  1.00 16.47  ? 101 GLY M CA  1 
ATOM   3991 C  C   . GLY D 1 106 ? 19.555  -38.762 25.737  1.00 15.67  ? 101 GLY M C   1 
ATOM   3992 O  O   . GLY D 1 106 ? 19.307  -39.776 25.084  1.00 19.24  ? 101 GLY M O   1 
ATOM   3993 N  N   . THR D 1 107 ? 19.978  -37.633 25.185  1.00 16.95  ? 102 THR M N   1 
ATOM   3994 C  CA  . THR D 1 107 ? 20.335  -37.528 23.776  1.00 19.85  ? 102 THR M CA  1 
ATOM   3995 C  C   . THR D 1 107 ? 21.662  -36.810 23.633  1.00 18.07  ? 102 THR M C   1 
ATOM   3996 O  O   . THR D 1 107 ? 21.802  -35.663 24.052  1.00 19.26  ? 102 THR M O   1 
ATOM   3997 C  CB  . THR D 1 107 ? 19.306  -36.717 22.972  1.00 16.92  ? 102 THR M CB  1 
ATOM   3998 O  OG1 . THR D 1 107 ? 18.008  -37.313 23.101  1.00 18.42  ? 102 THR M OG1 1 
ATOM   3999 C  CG2 . THR D 1 107 ? 19.696  -36.701 21.509  1.00 15.97  ? 102 THR M CG2 1 
ATOM   4000 N  N   . GLU D 1 108 ? 22.633  -37.474 23.022  1.00 17.04  ? 103 GLU M N   1 
ATOM   4001 C  CA  . GLU D 1 108 ? 23.922  -36.837 22.772  1.00 19.57  ? 103 GLU M CA  1 
ATOM   4002 C  C   . GLU D 1 108 ? 23.849  -36.048 21.460  1.00 19.12  ? 103 GLU M C   1 
ATOM   4003 O  O   . GLU D 1 108 ? 23.575  -36.613 20.410  1.00 18.17  ? 103 GLU M O   1 
ATOM   4004 C  CB  . GLU D 1 108 ? 25.032  -37.881 22.661  1.00 20.67  ? 103 GLU M CB  1 
ATOM   4005 C  CG  . GLU D 1 108 ? 25.255  -38.701 23.922  1.00 36.97  ? 103 GLU M CG  1 
ATOM   4006 C  CD  . GLU D 1 108 ? 26.426  -39.664 23.780  1.00 47.09  ? 103 GLU M CD  1 
ATOM   4007 O  OE1 . GLU D 1 108 ? 27.054  -39.677 22.700  1.00 53.72  ? 103 GLU M OE1 1 
ATOM   4008 O  OE2 . GLU D 1 108 ? 26.720  -40.404 24.741  1.00 43.49  ? 103 GLU M OE2 1 
ATOM   4009 N  N   . VAL D 1 109 ? 24.091  -34.750 21.524  1.00 17.24  ? 104 VAL M N   1 
ATOM   4010 C  CA  . VAL D 1 109 ? 24.038  -33.911 20.325  1.00 15.18  ? 104 VAL M CA  1 
ATOM   4011 C  C   . VAL D 1 109 ? 25.462  -33.527 19.891  1.00 17.26  ? 104 VAL M C   1 
ATOM   4012 O  O   . VAL D 1 109 ? 26.187  -32.860 20.622  1.00 17.00  ? 104 VAL M O   1 
ATOM   4013 C  CB  . VAL D 1 109 ? 23.191  -32.651 20.562  1.00 16.80  ? 104 VAL M CB  1 
ATOM   4014 C  CG1 . VAL D 1 109 ? 23.278  -31.718 19.354  1.00 22.66  ? 104 VAL M CG1 1 
ATOM   4015 C  CG2 . VAL D 1 109 ? 21.728  -33.038 20.831  1.00 13.26  ? 104 VAL M CG2 1 
ATOM   4016 N  N   . VAL D 1 110 ? 25.869  -34.010 18.724  1.00 16.33  ? 105 VAL M N   1 
ATOM   4017 C  CA  . VAL D 1 110 ? 27.156  -33.648 18.127  1.00 16.69  ? 105 VAL M CA  1 
ATOM   4018 C  C   . VAL D 1 110 ? 26.916  -32.566 17.083  1.00 19.91  ? 105 VAL M C   1 
ATOM   4019 O  O   . VAL D 1 110 ? 25.954  -32.666 16.319  1.00 17.35  ? 105 VAL M O   1 
ATOM   4020 C  CB  . VAL D 1 110 ? 27.823  -34.896 17.486  1.00 20.48  ? 105 VAL M CB  1 
ATOM   4021 C  CG1 . VAL D 1 110 ? 28.981  -34.485 16.584  1.00 17.60  ? 105 VAL M CG1 1 
ATOM   4022 C  CG2 . VAL D 1 110 ? 28.266  -35.885 18.603  1.00 17.21  ? 105 VAL M CG2 1 
ATOM   4023 N  N   . VAL D 1 111 ? 27.746  -31.517 17.072  1.00 15.03  ? 106 VAL M N   1 
ATOM   4024 C  CA  . VAL D 1 111 ? 27.519  -30.361 16.189  1.00 17.07  ? 106 VAL M CA  1 
ATOM   4025 C  C   . VAL D 1 111 ? 28.632  -30.235 15.142  1.00 18.69  ? 106 VAL M C   1 
ATOM   4026 O  O   . VAL D 1 111 ? 29.814  -30.164 15.491  1.00 17.43  ? 106 VAL M O   1 
ATOM   4027 C  CB  . VAL D 1 111 ? 27.462  -29.051 17.019  1.00 14.33  ? 106 VAL M CB  1 
ATOM   4028 C  CG1 . VAL D 1 111 ? 27.321  -27.806 16.123  1.00 15.95  ? 106 VAL M CG1 1 
ATOM   4029 C  CG2 . VAL D 1 111 ? 26.311  -29.118 18.037  1.00 15.34  ? 106 VAL M CG2 1 
ATOM   4030 N  N   . ARG D 1 112 ? 28.256  -30.203 13.865  1.00 19.01  ? 107 ARG M N   1 
ATOM   4031 C  CA  . ARG D 1 112 ? 29.238  -30.156 12.782  1.00 24.45  ? 107 ARG M CA  1 
ATOM   4032 C  C   . ARG D 1 112 ? 29.625  -28.733 12.395  1.00 25.06  ? 107 ARG M C   1 
ATOM   4033 O  O   . ARG D 1 112 ? 28.820  -27.992 11.835  1.00 25.20  ? 107 ARG M O   1 
ATOM   4034 C  CB  . ARG D 1 112 ? 28.734  -30.914 11.548  1.00 19.90  ? 107 ARG M CB  1 
ATOM   4035 C  CG  . ARG D 1 112 ? 28.518  -32.388 11.797  1.00 23.08  ? 107 ARG M CG  1 
ATOM   4036 C  CD  . ARG D 1 112 ? 28.258  -33.221 10.541  1.00 25.10  ? 107 ARG M CD  1 
ATOM   4037 N  NE  . ARG D 1 112 ? 27.207  -32.714 9.700   1.00 28.37  ? 107 ARG M NE  1 
ATOM   4038 C  CZ  . ARG D 1 112 ? 25.901  -32.948 9.708   1.00 23.23  ? 107 ARG M CZ  1 
ATOM   4039 N  NH1 . ARG D 1 112 ? 25.288  -33.744 10.569  1.00 19.33  ? 107 ARG M NH1 1 
ATOM   4040 N  NH2 . ARG D 1 112 ? 25.200  -32.322 8.776   1.00 23.15  ? 107 ARG M NH2 1 
ATOM   4041 N  N   . GLY D 1 113 ? 30.872  -28.367 12.678  1.00 22.87  ? 108 GLY M N   1 
ATOM   4042 C  CA  . GLY D 1 113 ? 31.363  -27.039 12.354  1.00 22.32  ? 108 GLY M CA  1 
ATOM   4043 C  C   . GLY D 1 113 ? 32.240  -27.034 11.114  1.00 21.80  ? 108 GLY M C   1 
ATOM   4044 O  O   . GLY D 1 113 ? 32.324  -28.019 10.381  1.00 21.89  ? 108 GLY M O   1 
ATOM   4045 N  N   . ASP D 1 114 ? 32.886  -25.906 10.861  1.00 26.19  ? 109 ASP M N   1 
ATOM   4046 C  CA  . ASP D 1 114 ? 33.825  -25.825 9.753   1.00 25.76  ? 109 ASP M CA  1 
ATOM   4047 C  C   . ASP D 1 114 ? 35.005  -26.777 9.953   1.00 27.47  ? 109 ASP M C   1 
ATOM   4048 O  O   . ASP D 1 114 ? 35.519  -26.912 11.060  1.00 25.82  ? 109 ASP M O   1 
ATOM   4049 C  CB  . ASP D 1 114 ? 34.332  -24.391 9.601   1.00 30.23  ? 109 ASP M CB  1 
ATOM   4050 C  CG  . ASP D 1 114 ? 33.219  -23.409 9.249   1.00 39.97  ? 109 ASP M CG  1 
ATOM   4051 O  OD1 . ASP D 1 114 ? 32.268  -23.795 8.526   1.00 32.91  ? 109 ASP M OD1 1 
ATOM   4052 O  OD2 . ASP D 1 114 ? 33.300  -22.250 9.700   1.00 48.52  ? 109 ASP M OD2 1 
ATOM   4053 N  N   . PRO D 1 115 ? 35.444  -27.437 8.878   1.00 25.30  ? 110 PRO M N   1 
ATOM   4054 C  CA  . PRO D 1 115 ? 36.561  -28.380 8.984   1.00 26.28  ? 110 PRO M CA  1 
ATOM   4055 C  C   . PRO D 1 115 ? 37.888  -27.701 9.318   1.00 30.16  ? 110 PRO M C   1 
ATOM   4056 O  O   . PRO D 1 115 ? 38.165  -26.608 8.831   1.00 24.64  ? 110 PRO M O   1 
ATOM   4057 C  CB  . PRO D 1 115 ? 36.615  -29.025 7.592   1.00 29.82  ? 110 PRO M CB  1 
ATOM   4058 C  CG  . PRO D 1 115 ? 35.956  -28.022 6.689   1.00 41.38  ? 110 PRO M CG  1 
ATOM   4059 C  CD  . PRO D 1 115 ? 34.892  -27.370 7.513   1.00 32.95  ? 110 PRO M CD  1 
ATOM   4060 N  N   . VAL D 1 116 ? 38.685  -28.350 10.163  1.00 24.70  ? 111 VAL M N   1 
ATOM   4061 C  CA  . VAL D 1 116 ? 40.002  -27.849 10.553  1.00 20.57  ? 111 VAL M CA  1 
ATOM   4062 C  C   . VAL D 1 116 ? 40.964  -29.028 10.578  1.00 26.42  ? 111 VAL M C   1 
ATOM   4063 O  O   . VAL D 1 116 ? 40.668  -30.063 11.184  1.00 22.34  ? 111 VAL M O   1 
ATOM   4064 C  CB  . VAL D 1 116 ? 39.979  -27.176 11.953  1.00 22.12  ? 111 VAL M CB  1 
ATOM   4065 C  CG1 . VAL D 1 116 ? 41.370  -26.638 12.339  1.00 23.15  ? 111 VAL M CG1 1 
ATOM   4066 C  CG2 . VAL D 1 116 ? 38.958  -26.062 12.016  1.00 20.42  ? 111 VAL M CG2 1 
ATOM   4067 N  N   . ALA D 1 117 ? 42.106  -28.896 9.906   1.00 22.39  ? 112 ALA M N   1 
ATOM   4068 C  CA  . ALA D 1 117 ? 43.107  -29.962 9.925   1.00 22.48  ? 112 ALA M CA  1 
ATOM   4069 C  C   . ALA D 1 117 ? 43.904  -29.931 11.231  1.00 18.71  ? 112 ALA M C   1 
ATOM   4070 O  O   . ALA D 1 117 ? 44.222  -28.858 11.746  1.00 21.55  ? 112 ALA M O   1 
ATOM   4071 C  CB  . ALA D 1 117 ? 44.051  -29.853 8.707   1.00 22.50  ? 112 ALA M CB  1 
ATOM   4072 N  N   . PRO D 1 118 ? 44.233  -31.110 11.784  1.00 16.83  ? 113 PRO M N   1 
ATOM   4073 C  CA  . PRO D 1 118 ? 44.959  -31.142 13.059  1.00 19.76  ? 113 PRO M CA  1 
ATOM   4074 C  C   . PRO D 1 118 ? 46.449  -30.812 12.913  1.00 21.46  ? 113 PRO M C   1 
ATOM   4075 O  O   . PRO D 1 118 ? 47.007  -31.045 11.845  1.00 21.34  ? 113 PRO M O   1 
ATOM   4076 C  CB  . PRO D 1 118 ? 44.820  -32.601 13.486  1.00 19.73  ? 113 PRO M CB  1 
ATOM   4077 C  CG  . PRO D 1 118 ? 44.750  -33.340 12.213  1.00 19.80  ? 113 PRO M CG  1 
ATOM   4078 C  CD  . PRO D 1 118 ? 44.028  -32.459 11.231  1.00 20.00  ? 113 PRO M CD  1 
ATOM   4079 N  N   . THR D 1 119 ? 47.077  -30.275 13.959  1.00 22.78  ? 114 THR M N   1 
ATOM   4080 C  CA  . THR D 1 119 ? 48.536  -30.358 14.070  1.00 24.86  ? 114 THR M CA  1 
ATOM   4081 C  C   . THR D 1 119 ? 48.841  -31.511 15.041  1.00 28.95  ? 114 THR M C   1 
ATOM   4082 O  O   . THR D 1 119 ? 47.988  -31.885 15.831  1.00 22.70  ? 114 THR M O   1 
ATOM   4083 C  CB  . THR D 1 119 ? 49.171  -29.055 14.565  1.00 27.51  ? 114 THR M CB  1 
ATOM   4084 O  OG1 . THR D 1 119 ? 48.576  -28.677 15.815  1.00 25.09  ? 114 THR M OG1 1 
ATOM   4085 C  CG2 . THR D 1 119 ? 48.985  -27.929 13.519  1.00 29.47  ? 114 THR M CG2 1 
ATOM   4086 N  N   . VAL D 1 120 ? 50.039  -32.080 14.971  1.00 23.65  ? 115 VAL M N   1 
ATOM   4087 C  CA  . VAL D 1 120 ? 50.330  -33.309 15.706  1.00 20.27  ? 115 VAL M CA  1 
ATOM   4088 C  C   . VAL D 1 120 ? 51.648  -33.224 16.490  1.00 20.35  ? 115 VAL M C   1 
ATOM   4089 O  O   . VAL D 1 120 ? 52.627  -32.664 16.002  1.00 19.64  ? 115 VAL M O   1 
ATOM   4090 C  CB  . VAL D 1 120 ? 50.382  -34.543 14.745  1.00 19.20  ? 115 VAL M CB  1 
ATOM   4091 C  CG1 . VAL D 1 120 ? 50.714  -35.838 15.520  1.00 21.59  ? 115 VAL M CG1 1 
ATOM   4092 C  CG2 . VAL D 1 120 ? 49.055  -34.708 13.976  1.00 19.53  ? 115 VAL M CG2 1 
ATOM   4093 N  N   . LEU D 1 121 ? 51.659  -33.789 17.697  1.00 16.92  ? 116 LEU M N   1 
ATOM   4094 C  CA  . LEU D 1 121 ? 52.844  -33.803 18.546  1.00 22.16  ? 116 LEU M CA  1 
ATOM   4095 C  C   . LEU D 1 121 ? 53.113  -35.225 19.006  1.00 24.69  ? 116 LEU M C   1 
ATOM   4096 O  O   . LEU D 1 121 ? 52.178  -35.959 19.297  1.00 20.23  ? 116 LEU M O   1 
ATOM   4097 C  CB  . LEU D 1 121 ? 52.621  -32.935 19.778  1.00 18.09  ? 116 LEU M CB  1 
ATOM   4098 C  CG  . LEU D 1 121 ? 52.166  -31.493 19.549  1.00 28.57  ? 116 LEU M CG  1 
ATOM   4099 C  CD1 . LEU D 1 121 ? 51.496  -30.974 20.793  1.00 30.95  ? 116 LEU M CD1 1 
ATOM   4100 C  CD2 . LEU D 1 121 ? 53.356  -30.622 19.218  1.00 28.47  ? 116 LEU M CD2 1 
ATOM   4101 N  N   . ILE D 1 122 ? 54.384  -35.613 19.071  1.00 20.40  ? 117 ILE M N   1 
ATOM   4102 C  CA  . ILE D 1 122 ? 54.738  -36.912 19.633  1.00 19.57  ? 117 ILE M CA  1 
ATOM   4103 C  C   . ILE D 1 122 ? 55.734  -36.728 20.768  1.00 25.85  ? 117 ILE M C   1 
ATOM   4104 O  O   . ILE D 1 122 ? 56.688  -35.936 20.653  1.00 20.32  ? 117 ILE M O   1 
ATOM   4105 C  CB  . ILE D 1 122 ? 55.240  -37.907 18.544  1.00 24.21  ? 117 ILE M CB  1 
ATOM   4106 C  CG1 . ILE D 1 122 ? 55.385  -39.325 19.118  1.00 22.54  ? 117 ILE M CG1 1 
ATOM   4107 C  CG2 . ILE D 1 122 ? 56.545  -37.413 17.872  1.00 21.62  ? 117 ILE M CG2 1 
ATOM   4108 C  CD1 . ILE D 1 122 ? 55.508  -40.374 18.060  1.00 24.20  ? 117 ILE M CD1 1 
ATOM   4109 N  N   . PHE D 1 123 ? 55.496  -37.438 21.873  1.00 21.60  ? 118 PHE M N   1 
ATOM   4110 C  CA  . PHE D 1 123 ? 56.348  -37.336 23.057  1.00 19.94  ? 118 PHE M CA  1 
ATOM   4111 C  C   . PHE D 1 123 ? 57.000  -38.668 23.381  1.00 29.19  ? 118 PHE M C   1 
ATOM   4112 O  O   . PHE D 1 123 ? 56.309  -39.627 23.725  1.00 25.82  ? 118 PHE M O   1 
ATOM   4113 C  CB  . PHE D 1 123 ? 55.551  -36.896 24.274  1.00 20.38  ? 118 PHE M CB  1 
ATOM   4114 C  CG  . PHE D 1 123 ? 54.876  -35.581 24.115  1.00 25.37  ? 118 PHE M CG  1 
ATOM   4115 C  CD1 . PHE D 1 123 ? 55.577  -34.401 24.300  1.00 22.71  ? 118 PHE M CD1 1 
ATOM   4116 C  CD2 . PHE D 1 123 ? 53.527  -35.515 23.802  1.00 30.81  ? 118 PHE M CD2 1 
ATOM   4117 C  CE1 . PHE D 1 123 ? 54.945  -33.177 24.164  1.00 23.94  ? 118 PHE M CE1 1 
ATOM   4118 C  CE2 . PHE D 1 123 ? 52.896  -34.283 23.667  1.00 30.98  ? 118 PHE M CE2 1 
ATOM   4119 C  CZ  . PHE D 1 123 ? 53.612  -33.123 23.848  1.00 25.67  ? 118 PHE M CZ  1 
ATOM   4120 N  N   . PRO D 1 124 ? 58.336  -38.728 23.292  1.00 26.56  ? 119 PRO M N   1 
ATOM   4121 C  CA  . PRO D 1 124 ? 59.074  -39.933 23.699  1.00 26.78  ? 119 PRO M CA  1 
ATOM   4122 C  C   . PRO D 1 124 ? 58.966  -40.186 25.208  1.00 23.61  ? 119 PRO M C   1 
ATOM   4123 O  O   . PRO D 1 124 ? 58.665  -39.279 25.986  1.00 23.65  ? 119 PRO M O   1 
ATOM   4124 C  CB  . PRO D 1 124 ? 60.521  -39.627 23.275  1.00 32.32  ? 119 PRO M CB  1 
ATOM   4125 C  CG  . PRO D 1 124 ? 60.590  -38.133 23.185  1.00 35.92  ? 119 PRO M CG  1 
ATOM   4126 C  CD  . PRO D 1 124 ? 59.221  -37.671 22.771  1.00 27.56  ? 119 PRO M CD  1 
ATOM   4127 N  N   . PRO D 1 125 ? 59.185  -41.436 25.631  1.00 24.14  ? 120 PRO M N   1 
ATOM   4128 C  CA  . PRO D 1 125 ? 59.057  -41.785 27.052  1.00 28.82  ? 120 PRO M CA  1 
ATOM   4129 C  C   . PRO D 1 125 ? 60.124  -41.085 27.883  1.00 32.84  ? 120 PRO M C   1 
ATOM   4130 O  O   . PRO D 1 125 ? 61.275  -41.075 27.465  1.00 32.59  ? 120 PRO M O   1 
ATOM   4131 C  CB  . PRO D 1 125 ? 59.326  -43.294 27.076  1.00 29.63  ? 120 PRO M CB  1 
ATOM   4132 C  CG  . PRO D 1 125 ? 59.322  -43.740 25.658  1.00 28.49  ? 120 PRO M CG  1 
ATOM   4133 C  CD  . PRO D 1 125 ? 59.651  -42.566 24.814  1.00 29.87  ? 120 PRO M CD  1 
ATOM   4134 N  N   . ALA D 1 126 ? 59.751  -40.504 29.021  1.00 29.53  ? 121 ALA M N   1 
ATOM   4135 C  CA  . ALA D 1 126 ? 60.734  -39.916 29.924  1.00 33.68  ? 121 ALA M CA  1 
ATOM   4136 C  C   . ALA D 1 126 ? 61.706  -41.000 30.379  1.00 36.76  ? 121 ALA M C   1 
ATOM   4137 O  O   . ALA D 1 126 ? 61.324  -42.162 30.502  1.00 29.13  ? 121 ALA M O   1 
ATOM   4138 C  CB  . ALA D 1 126 ? 60.048  -39.289 31.117  1.00 29.58  ? 121 ALA M CB  1 
ATOM   4139 N  N   . ALA D 1 127 ? 62.957  -40.616 30.620  1.00 40.04  ? 122 ALA M N   1 
ATOM   4140 C  CA  . ALA D 1 127 ? 64.011  -41.565 30.986  1.00 38.19  ? 122 ALA M CA  1 
ATOM   4141 C  C   . ALA D 1 127 ? 63.625  -42.458 32.170  1.00 34.73  ? 122 ALA M C   1 
ATOM   4142 O  O   . ALA D 1 127 ? 63.922  -43.650 32.184  1.00 42.88  ? 122 ALA M O   1 
ATOM   4143 C  CB  . ALA D 1 127 ? 65.318  -40.825 31.270  1.00 43.35  ? 122 ALA M CB  1 
ATOM   4144 N  N   . ASP D 1 128 ? 62.926  -41.880 33.140  1.00 42.59  ? 123 ASP M N   1 
ATOM   4145 C  CA  . ASP D 1 128 ? 62.434  -42.630 34.294  1.00 40.37  ? 123 ASP M CA  1 
ATOM   4146 C  C   . ASP D 1 128 ? 61.530  -43.813 33.959  1.00 42.98  ? 123 ASP M C   1 
ATOM   4147 O  O   . ASP D 1 128 ? 61.360  -44.713 34.782  1.00 41.03  ? 123 ASP M O   1 
ATOM   4148 C  CB  . ASP D 1 128 ? 61.669  -41.708 35.238  1.00 42.83  ? 123 ASP M CB  1 
ATOM   4149 C  CG  . ASP D 1 128 ? 62.571  -40.754 35.974  1.00 63.01  ? 123 ASP M CG  1 
ATOM   4150 O  OD1 . ASP D 1 128 ? 63.799  -40.991 35.999  1.00 62.56  ? 123 ASP M OD1 1 
ATOM   4151 O  OD2 . ASP D 1 128 ? 62.047  -39.769 36.537  1.00 75.82  ? 123 ASP M OD2 1 
ATOM   4152 N  N   . GLN D 1 129 ? 60.925  -43.805 32.775  1.00 39.94  ? 124 GLN M N   1 
ATOM   4153 C  CA  . GLN D 1 129 ? 59.949  -44.841 32.432  1.00 36.46  ? 124 GLN M CA  1 
ATOM   4154 C  C   . GLN D 1 129 ? 60.536  -46.228 32.194  1.00 44.41  ? 124 GLN M C   1 
ATOM   4155 O  O   . GLN D 1 129 ? 60.000  -47.222 32.699  1.00 37.64  ? 124 GLN M O   1 
ATOM   4156 C  CB  . GLN D 1 129 ? 59.111  -44.438 31.217  1.00 43.05  ? 124 GLN M CB  1 
ATOM   4157 C  CG  . GLN D 1 129 ? 58.008  -43.458 31.530  1.00 32.16  ? 124 GLN M CG  1 
ATOM   4158 C  CD  . GLN D 1 129 ? 56.916  -43.441 30.471  1.00 34.87  ? 124 GLN M CD  1 
ATOM   4159 O  OE1 . GLN D 1 129 ? 56.266  -44.456 30.222  1.00 35.56  ? 124 GLN M OE1 1 
ATOM   4160 N  NE2 . GLN D 1 129 ? 56.704  -42.275 29.846  1.00 32.48  ? 124 GLN M NE2 1 
ATOM   4161 N  N   . VAL D 1 130 ? 61.615  -46.297 31.412  1.00 40.98  ? 125 VAL M N   1 
ATOM   4162 C  CA  . VAL D 1 130 ? 62.202  -47.581 31.033  1.00 42.12  ? 125 VAL M CA  1 
ATOM   4163 C  C   . VAL D 1 130 ? 62.579  -48.420 32.250  1.00 38.31  ? 125 VAL M C   1 
ATOM   4164 O  O   . VAL D 1 130 ? 62.526  -49.647 32.200  1.00 43.79  ? 125 VAL M O   1 
ATOM   4165 C  CB  . VAL D 1 130 ? 63.434  -47.423 30.109  1.00 48.81  ? 125 VAL M CB  1 
ATOM   4166 C  CG1 . VAL D 1 130 ? 63.057  -46.657 28.858  1.00 57.08  ? 125 VAL M CG1 1 
ATOM   4167 C  CG2 . VAL D 1 130 ? 64.574  -46.727 30.836  1.00 56.07  ? 125 VAL M CG2 1 
ATOM   4168 N  N   . ALA D 1 131 ? 62.926  -47.751 33.345  1.00 40.54  ? 126 ALA M N   1 
ATOM   4169 C  CA  . ALA D 1 131 ? 63.331  -48.435 34.562  1.00 41.54  ? 126 ALA M CA  1 
ATOM   4170 C  C   . ALA D 1 131 ? 62.190  -49.259 35.145  1.00 52.14  ? 126 ALA M C   1 
ATOM   4171 O  O   . ALA D 1 131 ? 62.426  -50.283 35.786  1.00 51.63  ? 126 ALA M O   1 
ATOM   4172 C  CB  . ALA D 1 131 ? 63.842  -47.434 35.586  1.00 43.20  ? 126 ALA M CB  1 
ATOM   4173 N  N   . THR D 1 132 ? 60.955  -48.820 34.914  1.00 41.09  ? 127 THR M N   1 
ATOM   4174 C  CA  . THR D 1 132 ? 59.798  -49.496 35.488  1.00 40.78  ? 127 THR M CA  1 
ATOM   4175 C  C   . THR D 1 132 ? 59.491  -50.811 34.778  1.00 38.67  ? 127 THR M C   1 
ATOM   4176 O  O   . THR D 1 132 ? 58.727  -51.625 35.289  1.00 45.06  ? 127 THR M O   1 
ATOM   4177 C  CB  . THR D 1 132 ? 58.526  -48.621 35.420  1.00 38.81  ? 127 THR M CB  1 
ATOM   4178 O  OG1 . THR D 1 132 ? 58.092  -48.525 34.059  1.00 34.66  ? 127 THR M OG1 1 
ATOM   4179 C  CG2 . THR D 1 132 ? 58.784  -47.229 35.992  1.00 31.45  ? 127 THR M CG2 1 
ATOM   4180 N  N   . GLY D 1 133 ? 60.052  -50.997 33.588  1.00 34.19  ? 128 GLY M N   1 
ATOM   4181 C  CA  . GLY D 1 133 ? 59.775  -52.187 32.802  1.00 38.27  ? 128 GLY M CA  1 
ATOM   4182 C  C   . GLY D 1 133 ? 58.772  -51.996 31.679  1.00 41.12  ? 128 GLY M C   1 
ATOM   4183 O  O   . GLY D 1 133 ? 58.721  -52.794 30.734  1.00 31.07  ? 128 GLY M O   1 
ATOM   4184 N  N   . THR D 1 134 ? 57.966  -50.940 31.780  1.00 40.78  ? 129 THR M N   1 
ATOM   4185 C  CA  . THR D 1 134 ? 57.025  -50.597 30.719  1.00 38.04  ? 129 THR M CA  1 
ATOM   4186 C  C   . THR D 1 134 ? 57.154  -49.123 30.306  1.00 35.76  ? 129 THR M C   1 
ATOM   4187 O  O   . THR D 1 134 ? 57.512  -48.257 31.110  1.00 33.48  ? 129 THR M O   1 
ATOM   4188 C  CB  . THR D 1 134 ? 55.555  -50.905 31.106  1.00 42.89  ? 129 THR M CB  1 
ATOM   4189 O  OG1 . THR D 1 134 ? 55.209  -50.186 32.294  1.00 50.21  ? 129 THR M OG1 1 
ATOM   4190 C  CG2 . THR D 1 134 ? 55.347  -52.405 31.337  1.00 43.67  ? 129 THR M CG2 1 
ATOM   4191 N  N   . VAL D 1 135 ? 56.844  -48.859 29.044  1.00 30.42  ? 130 VAL M N   1 
ATOM   4192 C  CA  . VAL D 1 135 ? 57.096  -47.563 28.424  1.00 30.33  ? 130 VAL M CA  1 
ATOM   4193 C  C   . VAL D 1 135 ? 55.833  -47.134 27.687  1.00 32.73  ? 130 VAL M C   1 
ATOM   4194 O  O   . VAL D 1 135 ? 55.208  -47.942 26.988  1.00 27.34  ? 130 VAL M O   1 
ATOM   4195 C  CB  . VAL D 1 135 ? 58.296  -47.679 27.462  1.00 31.00  ? 130 VAL M CB  1 
ATOM   4196 C  CG1 . VAL D 1 135 ? 58.077  -46.905 26.192  1.00 36.39  ? 130 VAL M CG1 1 
ATOM   4197 C  CG2 . VAL D 1 135 ? 59.593  -47.265 28.168  1.00 32.41  ? 130 VAL M CG2 1 
ATOM   4198 N  N   . THR D 1 136 ? 55.451  -45.871 27.867  1.00 30.65  ? 131 THR M N   1 
ATOM   4199 C  CA  . THR D 1 136 ? 54.265  -45.304 27.223  1.00 27.04  ? 131 THR M CA  1 
ATOM   4200 C  C   . THR D 1 136 ? 54.622  -44.115 26.319  1.00 23.31  ? 131 THR M C   1 
ATOM   4201 O  O   . THR D 1 136 ? 55.167  -43.104 26.790  1.00 24.52  ? 131 THR M O   1 
ATOM   4202 C  CB  . THR D 1 136 ? 53.231  -44.863 28.288  1.00 32.40  ? 131 THR M CB  1 
ATOM   4203 O  OG1 . THR D 1 136 ? 52.805  -46.004 29.038  1.00 38.76  ? 131 THR M OG1 1 
ATOM   4204 C  CG2 . THR D 1 136 ? 52.003  -44.227 27.639  1.00 28.01  ? 131 THR M CG2 1 
ATOM   4205 N  N   . ILE D 1 137 ? 54.341  -44.239 25.021  1.00 17.94  ? 132 ILE M N   1 
ATOM   4206 C  CA  . ILE D 1 137 ? 54.616  -43.149 24.089  1.00 19.60  ? 132 ILE M CA  1 
ATOM   4207 C  C   . ILE D 1 137 ? 53.326  -42.386 23.830  1.00 25.60  ? 132 ILE M C   1 
ATOM   4208 O  O   . ILE D 1 137 ? 52.293  -43.011 23.647  1.00 25.69  ? 132 ILE M O   1 
ATOM   4209 C  CB  . ILE D 1 137 ? 55.192  -43.660 22.757  1.00 22.91  ? 132 ILE M CB  1 
ATOM   4210 C  CG1 . ILE D 1 137 ? 56.336  -44.652 23.029  1.00 29.10  ? 132 ILE M CG1 1 
ATOM   4211 C  CG2 . ILE D 1 137 ? 55.638  -42.468 21.871  1.00 19.56  ? 132 ILE M CG2 1 
ATOM   4212 C  CD1 . ILE D 1 137 ? 56.757  -45.450 21.820  1.00 34.86  ? 132 ILE M CD1 1 
ATOM   4213 N  N   . VAL D 1 138 ? 53.377  -41.050 23.829  1.00 23.42  ? 133 VAL M N   1 
ATOM   4214 C  CA  . VAL D 1 138 ? 52.151  -40.253 23.728  1.00 21.02  ? 133 VAL M CA  1 
ATOM   4215 C  C   . VAL D 1 138 ? 52.103  -39.437 22.446  1.00 24.56  ? 133 VAL M C   1 
ATOM   4216 O  O   . VAL D 1 138 ? 53.051  -38.744 22.117  1.00 21.42  ? 133 VAL M O   1 
ATOM   4217 C  CB  . VAL D 1 138 ? 51.960  -39.302 24.947  1.00 17.96  ? 133 VAL M CB  1 
ATOM   4218 C  CG1 . VAL D 1 138 ? 50.658  -38.503 24.814  1.00 19.86  ? 133 VAL M CG1 1 
ATOM   4219 C  CG2 . VAL D 1 138 ? 51.963  -40.090 26.255  1.00 21.57  ? 133 VAL M CG2 1 
ATOM   4220 N  N   . CYS D 1 139 ? 50.984  -39.527 21.731  1.00 20.58  ? 134 CYS M N   1 
ATOM   4221 C  CA  . CYS D 1 139 ? 50.754  -38.729 20.535  1.00 18.04  ? 134 CYS M CA  1 
ATOM   4222 C  C   . CYS D 1 139 ? 49.530  -37.870 20.743  1.00 22.79  ? 134 CYS M C   1 
ATOM   4223 O  O   . CYS D 1 139 ? 48.506  -38.361 21.231  1.00 21.17  ? 134 CYS M O   1 
ATOM   4224 C  CB  . CYS D 1 139 ? 50.541  -39.653 19.325  1.00 16.06  ? 134 CYS M CB  1 
ATOM   4225 S  SG  . CYS D 1 139 ? 50.256  -38.800 17.774  1.00 22.42  ? 134 CYS M SG  1 
ATOM   4226 N  N   . VAL D 1 140 ? 49.618  -36.597 20.371  1.00 19.03  ? 135 VAL M N   1 
ATOM   4227 C  CA  . VAL D 1 140 ? 48.473  -35.689 20.492  1.00 20.24  ? 135 VAL M CA  1 
ATOM   4228 C  C   . VAL D 1 140 ? 48.084  -35.067 19.139  1.00 21.96  ? 135 VAL M C   1 
ATOM   4229 O  O   . VAL D 1 140 ? 48.945  -34.602 18.392  1.00 19.35  ? 135 VAL M O   1 
ATOM   4230 C  CB  . VAL D 1 140 ? 48.756  -34.541 21.475  1.00 25.80  ? 135 VAL M CB  1 
ATOM   4231 C  CG1 . VAL D 1 140 ? 47.588  -33.585 21.486  1.00 26.55  ? 135 VAL M CG1 1 
ATOM   4232 C  CG2 . VAL D 1 140 ? 49.043  -35.081 22.886  1.00 23.37  ? 135 VAL M CG2 1 
ATOM   4233 N  N   . ALA D 1 141 ? 46.787  -35.067 18.834  1.00 17.99  ? 136 ALA M N   1 
ATOM   4234 C  CA  . ALA D 1 141 ? 46.268  -34.344 17.682  1.00 18.92  ? 136 ALA M CA  1 
ATOM   4235 C  C   . ALA D 1 141 ? 45.446  -33.157 18.184  1.00 20.73  ? 136 ALA M C   1 
ATOM   4236 O  O   . ALA D 1 141 ? 44.452  -33.353 18.891  1.00 21.11  ? 136 ALA M O   1 
ATOM   4237 C  CB  . ALA D 1 141 ? 45.415  -35.274 16.814  1.00 18.90  ? 136 ALA M CB  1 
ATOM   4238 N  N   . ASN D 1 142 ? 45.872  -31.940 17.823  1.00 21.80  ? 137 ASN M N   1 
ATOM   4239 C  CA  . ASN D 1 142 ? 45.289  -30.683 18.324  1.00 26.21  ? 137 ASN M CA  1 
ATOM   4240 C  C   . ASN D 1 142 ? 44.211  -30.066 17.422  1.00 24.35  ? 137 ASN M C   1 
ATOM   4241 O  O   . ASN D 1 142 ? 44.430  -29.909 16.226  1.00 22.86  ? 137 ASN M O   1 
ATOM   4242 C  CB  . ASN D 1 142 ? 46.372  -29.603 18.429  1.00 23.86  ? 137 ASN M CB  1 
ATOM   4243 C  CG  . ASN D 1 142 ? 47.605  -30.056 19.177  1.00 37.48  ? 137 ASN M CG  1 
ATOM   4244 O  OD1 . ASN D 1 142 ? 47.515  -30.636 20.262  1.00 35.11  ? 137 ASN M OD1 1 
ATOM   4245 N  ND2 . ASN D 1 142 ? 48.784  -29.762 18.607  1.00 32.08  ? 137 ASN M ND2 1 
ATOM   4246 N  N   . LYS D 1 143 ? 43.084  -29.675 18.015  1.00 21.80  ? 138 LYS M N   1 
ATOM   4247 C  CA  . LYS D 1 143 ? 42.151  -28.722 17.405  1.00 22.01  ? 138 LYS M CA  1 
ATOM   4248 C  C   . LYS D 1 143 ? 41.724  -29.110 15.979  1.00 18.55  ? 138 LYS M C   1 
ATOM   4249 O  O   . LYS D 1 143 ? 42.102  -28.466 15.011  1.00 23.84  ? 138 LYS M O   1 
ATOM   4250 C  CB  . LYS D 1 143 ? 42.779  -27.318 17.430  1.00 23.54  ? 138 LYS M CB  1 
ATOM   4251 C  CG  . LYS D 1 143 ? 41.861  -26.160 17.052  1.00 22.76  ? 138 LYS M CG  1 
ATOM   4252 C  CD  . LYS D 1 143 ? 42.592  -24.841 17.307  1.00 32.70  ? 138 LYS M CD  1 
ATOM   4253 C  CE  . LYS D 1 143 ? 41.880  -23.641 16.706  1.00 47.59  ? 138 LYS M CE  1 
ATOM   4254 N  NZ  . LYS D 1 143 ? 40.657  -23.284 17.486  1.00 49.64  ? 138 LYS M NZ  1 
ATOM   4255 N  N   . TYR D 1 144 ? 40.945  -30.176 15.847  1.00 17.99  ? 139 TYR M N   1 
ATOM   4256 C  CA  . TYR D 1 144 ? 40.554  -30.639 14.517  1.00 17.49  ? 139 TYR M CA  1 
ATOM   4257 C  C   . TYR D 1 144 ? 39.052  -30.932 14.416  1.00 23.10  ? 139 TYR M C   1 
ATOM   4258 O  O   . TYR D 1 144 ? 38.371  -31.123 15.417  1.00 19.32  ? 139 TYR M O   1 
ATOM   4259 C  CB  . TYR D 1 144 ? 41.344  -31.901 14.156  1.00 15.73  ? 139 TYR M CB  1 
ATOM   4260 C  CG  . TYR D 1 144 ? 41.027  -33.075 15.071  1.00 19.46  ? 139 TYR M CG  1 
ATOM   4261 C  CD1 . TYR D 1 144 ? 39.958  -33.923 14.801  1.00 20.34  ? 139 TYR M CD1 1 
ATOM   4262 C  CD2 . TYR D 1 144 ? 41.793  -33.328 16.213  1.00 17.80  ? 139 TYR M CD2 1 
ATOM   4263 C  CE1 . TYR D 1 144 ? 39.649  -34.998 15.643  1.00 18.72  ? 139 TYR M CE1 1 
ATOM   4264 C  CE2 . TYR D 1 144 ? 41.493  -34.403 17.054  1.00 16.38  ? 139 TYR M CE2 1 
ATOM   4265 C  CZ  . TYR D 1 144 ? 40.423  -35.227 16.770  1.00 18.73  ? 139 TYR M CZ  1 
ATOM   4266 O  OH  . TYR D 1 144 ? 40.111  -36.287 17.612  1.00 19.30  ? 139 TYR M OH  1 
ATOM   4267 N  N   . PHE D 1 145 ? 38.560  -30.996 13.188  1.00 17.53  ? 140 PHE M N   1 
ATOM   4268 C  CA  . PHE D 1 145 ? 37.217  -31.464 12.895  1.00 19.72  ? 140 PHE M CA  1 
ATOM   4269 C  C   . PHE D 1 145 ? 37.173  -31.677 11.395  1.00 24.07  ? 140 PHE M C   1 
ATOM   4270 O  O   . PHE D 1 145 ? 37.700  -30.853 10.650  1.00 26.24  ? 140 PHE M O   1 
ATOM   4271 C  CB  . PHE D 1 145 ? 36.150  -30.439 13.298  1.00 19.57  ? 140 PHE M CB  1 
ATOM   4272 C  CG  . PHE D 1 145 ? 34.751  -30.969 13.190  1.00 19.62  ? 140 PHE M CG  1 
ATOM   4273 C  CD1 . PHE D 1 145 ? 34.147  -31.569 14.273  1.00 21.22  ? 140 PHE M CD1 1 
ATOM   4274 C  CD2 . PHE D 1 145 ? 34.054  -30.906 11.992  1.00 23.50  ? 140 PHE M CD2 1 
ATOM   4275 C  CE1 . PHE D 1 145 ? 32.859  -32.083 14.181  1.00 22.10  ? 140 PHE M CE1 1 
ATOM   4276 C  CE2 . PHE D 1 145 ? 32.770  -31.428 11.888  1.00 19.36  ? 140 PHE M CE2 1 
ATOM   4277 C  CZ  . PHE D 1 145 ? 32.175  -32.010 12.988  1.00 22.75  ? 140 PHE M CZ  1 
ATOM   4278 N  N   . PRO D 1 146 ? 36.549  -32.773 10.933  1.00 25.12  ? 141 PRO M N   1 
ATOM   4279 C  CA  . PRO D 1 146 ? 35.850  -33.845 11.667  1.00 23.79  ? 141 PRO M CA  1 
ATOM   4280 C  C   . PRO D 1 146 ? 36.808  -34.880 12.246  1.00 22.64  ? 141 PRO M C   1 
ATOM   4281 O  O   . PRO D 1 146 ? 38.028  -34.644 12.244  1.00 21.43  ? 141 PRO M O   1 
ATOM   4282 C  CB  . PRO D 1 146 ? 34.999  -34.497 10.580  1.00 24.13  ? 141 PRO M CB  1 
ATOM   4283 C  CG  . PRO D 1 146 ? 35.867  -34.351 9.330   1.00 26.62  ? 141 PRO M CG  1 
ATOM   4284 C  CD  . PRO D 1 146 ? 36.479  -32.969 9.468   1.00 26.62  ? 141 PRO M CD  1 
ATOM   4285 N  N   . ASP D 1 147 ? 36.269  -36.006 12.717  1.00 18.59  ? 142 ASP M N   1 
ATOM   4286 C  CA  . ASP D 1 147 ? 37.068  -37.041 13.367  1.00 20.36  ? 142 ASP M CA  1 
ATOM   4287 C  C   . ASP D 1 147 ? 38.260  -37.522 12.535  1.00 27.34  ? 142 ASP M C   1 
ATOM   4288 O  O   . ASP D 1 147 ? 38.241  -37.420 11.309  1.00 23.20  ? 142 ASP M O   1 
ATOM   4289 C  CB  . ASP D 1 147 ? 36.193  -38.231 13.745  1.00 27.78  ? 142 ASP M CB  1 
ATOM   4290 C  CG  . ASP D 1 147 ? 35.390  -37.980 15.016  1.00 29.71  ? 142 ASP M CG  1 
ATOM   4291 O  OD1 . ASP D 1 147 ? 35.994  -37.619 16.045  1.00 24.15  ? 142 ASP M OD1 1 
ATOM   4292 O  OD2 . ASP D 1 147 ? 34.155  -38.126 14.982  1.00 29.28  ? 142 ASP M OD2 1 
ATOM   4293 N  N   . VAL D 1 148 ? 39.290  -38.029 13.223  1.00 23.14  ? 143 VAL M N   1 
ATOM   4294 C  CA  . VAL D 1 148 ? 40.492  -38.566 12.582  1.00 18.33  ? 143 VAL M CA  1 
ATOM   4295 C  C   . VAL D 1 148 ? 40.672  -40.035 12.937  1.00 25.69  ? 143 VAL M C   1 
ATOM   4296 O  O   . VAL D 1 148 ? 39.977  -40.563 13.807  1.00 25.15  ? 143 VAL M O   1 
ATOM   4297 C  CB  . VAL D 1 148 ? 41.779  -37.827 13.045  1.00 20.74  ? 143 VAL M CB  1 
ATOM   4298 C  CG1 . VAL D 1 148 ? 41.759  -36.339 12.619  1.00 21.62  ? 143 VAL M CG1 1 
ATOM   4299 C  CG2 . VAL D 1 148 ? 41.970  -37.973 14.541  1.00 17.13  ? 143 VAL M CG2 1 
ATOM   4300 N  N   . THR D 1 149 ? 41.605  -40.697 12.262  1.00 24.27  ? 144 THR M N   1 
ATOM   4301 C  CA  . THR D 1 149 ? 42.045  -42.024 12.674  1.00 25.09  ? 144 THR M CA  1 
ATOM   4302 C  C   . THR D 1 149 ? 43.543  -41.944 12.960  1.00 25.96  ? 144 THR M C   1 
ATOM   4303 O  O   . THR D 1 149 ? 44.245  -41.124 12.375  1.00 23.45  ? 144 THR M O   1 
ATOM   4304 C  CB  . THR D 1 149 ? 41.785  -43.084 11.583  1.00 27.39  ? 144 THR M CB  1 
ATOM   4305 O  OG1 . THR D 1 149 ? 42.373  -42.648 10.354  1.00 33.88  ? 144 THR M OG1 1 
ATOM   4306 C  CG2 . THR D 1 149 ? 40.290  -43.281 11.371  1.00 33.58  ? 144 THR M CG2 1 
ATOM   4307 N  N   . VAL D 1 150 ? 44.026  -42.773 13.875  1.00 22.70  ? 145 VAL M N   1 
ATOM   4308 C  CA  . VAL D 1 150 ? 45.431  -42.758 14.242  1.00 24.82  ? 145 VAL M CA  1 
ATOM   4309 C  C   . VAL D 1 150 ? 46.050  -44.106 13.933  1.00 32.14  ? 145 VAL M C   1 
ATOM   4310 O  O   . VAL D 1 150 ? 45.458  -45.142 14.233  1.00 31.16  ? 145 VAL M O   1 
ATOM   4311 C  CB  . VAL D 1 150 ? 45.615  -42.495 15.743  1.00 27.14  ? 145 VAL M CB  1 
ATOM   4312 C  CG1 . VAL D 1 150 ? 47.098  -42.401 16.091  1.00 22.09  ? 145 VAL M CG1 1 
ATOM   4313 C  CG2 . VAL D 1 150 ? 44.916  -41.221 16.134  1.00 32.24  ? 145 VAL M CG2 1 
ATOM   4314 N  N   . THR D 1 151 ? 47.244  -44.082 13.346  1.00 31.08  ? 146 THR M N   1 
ATOM   4315 C  CA  . THR D 1 151 ? 48.023  -45.290 13.070  1.00 35.82  ? 146 THR M CA  1 
ATOM   4316 C  C   . THR D 1 151 ? 49.403  -45.197 13.715  1.00 31.17  ? 146 THR M C   1 
ATOM   4317 O  O   . THR D 1 151 ? 50.118  -44.211 13.539  1.00 29.85  ? 146 THR M O   1 
ATOM   4318 C  CB  . THR D 1 151 ? 48.224  -45.497 11.544  1.00 33.29  ? 146 THR M CB  1 
ATOM   4319 O  OG1 . THR D 1 151 ? 46.971  -45.814 10.930  1.00 41.17  ? 146 THR M OG1 1 
ATOM   4320 C  CG2 . THR D 1 151 ? 49.216  -46.619 11.268  1.00 39.97  ? 146 THR M CG2 1 
ATOM   4321 N  N   . TRP D 1 152 ? 49.775  -46.221 14.467  1.00 29.42  ? 147 TRP M N   1 
ATOM   4322 C  CA  . TRP D 1 152 ? 51.116  -46.287 15.023  1.00 32.24  ? 147 TRP M CA  1 
ATOM   4323 C  C   . TRP D 1 152 ? 51.973  -47.241 14.185  1.00 41.95  ? 147 TRP M C   1 
ATOM   4324 O  O   . TRP D 1 152 ? 51.500  -48.300 13.759  1.00 36.41  ? 147 TRP M O   1 
ATOM   4325 C  CB  . TRP D 1 152 ? 51.067  -46.761 16.468  1.00 32.13  ? 147 TRP M CB  1 
ATOM   4326 C  CG  . TRP D 1 152 ? 50.639  -45.717 17.474  1.00 35.00  ? 147 TRP M CG  1 
ATOM   4327 C  CD1 . TRP D 1 152 ? 49.360  -45.451 17.902  1.00 30.98  ? 147 TRP M CD1 1 
ATOM   4328 C  CD2 . TRP D 1 152 ? 51.495  -44.827 18.199  1.00 29.79  ? 147 TRP M CD2 1 
ATOM   4329 N  NE1 . TRP D 1 152 ? 49.376  -44.442 18.845  1.00 29.27  ? 147 TRP M NE1 1 
ATOM   4330 C  CE2 . TRP D 1 152 ? 50.675  -44.044 19.039  1.00 32.43  ? 147 TRP M CE2 1 
ATOM   4331 C  CE3 . TRP D 1 152 ? 52.878  -44.610 18.212  1.00 26.82  ? 147 TRP M CE3 1 
ATOM   4332 C  CZ2 . TRP D 1 152 ? 51.193  -43.070 19.881  1.00 27.65  ? 147 TRP M CZ2 1 
ATOM   4333 C  CZ3 . TRP D 1 152 ? 53.388  -43.638 19.051  1.00 29.87  ? 147 TRP M CZ3 1 
ATOM   4334 C  CH2 . TRP D 1 152 ? 52.549  -42.881 19.873  1.00 29.41  ? 147 TRP M CH2 1 
ATOM   4335 N  N   . GLU D 1 153 ? 53.223  -46.852 13.938  1.00 34.87  ? 148 GLU M N   1 
ATOM   4336 C  CA  . GLU D 1 153 ? 54.187  -47.711 13.244  1.00 36.89  ? 148 GLU M CA  1 
ATOM   4337 C  C   . GLU D 1 153 ? 55.511  -47.749 13.999  1.00 40.13  ? 148 GLU M C   1 
ATOM   4338 O  O   . GLU D 1 153 ? 56.012  -46.712 14.449  1.00 36.91  ? 148 GLU M O   1 
ATOM   4339 C  CB  . GLU D 1 153 ? 54.446  -47.211 11.828  1.00 35.17  ? 148 GLU M CB  1 
ATOM   4340 C  CG  . GLU D 1 153 ? 53.264  -47.299 10.903  1.00 48.31  ? 148 GLU M CG  1 
ATOM   4341 C  CD  . GLU D 1 153 ? 53.581  -46.737 9.538   1.00 57.04  ? 148 GLU M CD  1 
ATOM   4342 O  OE1 . GLU D 1 153 ? 54.776  -46.744 9.175   1.00 65.46  ? 148 GLU M OE1 1 
ATOM   4343 O  OE2 . GLU D 1 153 ? 52.649  -46.281 8.834   1.00 57.39  ? 148 GLU M OE2 1 
ATOM   4344 N  N   . VAL D 1 154 ? 56.064  -48.949 14.148  1.00 38.84  ? 149 VAL M N   1 
ATOM   4345 C  CA  . VAL D 1 154 ? 57.368  -49.141 14.773  1.00 37.19  ? 149 VAL M CA  1 
ATOM   4346 C  C   . VAL D 1 154 ? 58.303  -49.802 13.761  1.00 47.83  ? 149 VAL M C   1 
ATOM   4347 O  O   . VAL D 1 154 ? 58.087  -50.948 13.357  1.00 47.92  ? 149 VAL M O   1 
ATOM   4348 C  CB  . VAL D 1 154 ? 57.271  -50.002 16.039  1.00 39.90  ? 149 VAL M CB  1 
ATOM   4349 C  CG1 . VAL D 1 154 ? 58.648  -50.229 16.639  1.00 40.89  ? 149 VAL M CG1 1 
ATOM   4350 C  CG2 . VAL D 1 154 ? 56.351  -49.350 17.061  1.00 37.86  ? 149 VAL M CG2 1 
ATOM   4351 N  N   . ASP D 1 155 ? 59.329  -49.060 13.350  1.00 44.57  ? 150 ASP M N   1 
ATOM   4352 C  CA  . ASP D 1 155 ? 60.238  -49.486 12.290  1.00 43.79  ? 150 ASP M CA  1 
ATOM   4353 C  C   . ASP D 1 155 ? 59.491  -49.937 11.039  1.00 51.21  ? 150 ASP M C   1 
ATOM   4354 O  O   . ASP D 1 155 ? 59.861  -50.925 10.407  1.00 50.06  ? 150 ASP M O   1 
ATOM   4355 C  CB  . ASP D 1 155 ? 61.192  -50.583 12.784  1.00 42.39  ? 150 ASP M CB  1 
ATOM   4356 C  CG  . ASP D 1 155 ? 62.312  -50.030 13.657  1.00 42.61  ? 150 ASP M CG  1 
ATOM   4357 O  OD1 . ASP D 1 155 ? 62.667  -48.843 13.489  1.00 46.40  ? 150 ASP M OD1 1 
ATOM   4358 O  OD2 . ASP D 1 155 ? 62.835  -50.768 14.513  1.00 38.75  ? 150 ASP M OD2 1 
ATOM   4359 N  N   . GLY D 1 156 ? 58.432  -49.211 10.692  1.00 46.39  ? 151 GLY M N   1 
ATOM   4360 C  CA  . GLY D 1 156 ? 57.690  -49.489 9.474   1.00 45.34  ? 151 GLY M CA  1 
ATOM   4361 C  C   . GLY D 1 156 ? 56.501  -50.420 9.651   1.00 47.11  ? 151 GLY M C   1 
ATOM   4362 O  O   . GLY D 1 156 ? 55.623  -50.480 8.788   1.00 53.20  ? 151 GLY M O   1 
ATOM   4363 N  N   . THR D 1 157 ? 56.467  -51.138 10.770  1.00 41.94  ? 152 THR M N   1 
ATOM   4364 C  CA  . THR D 1 157 ? 55.420  -52.116 11.027  1.00 46.33  ? 152 THR M CA  1 
ATOM   4365 C  C   . THR D 1 157 ? 54.234  -51.527 11.797  1.00 45.61  ? 152 THR M C   1 
ATOM   4366 O  O   . THR D 1 157 ? 54.391  -51.047 12.920  1.00 40.19  ? 152 THR M O   1 
ATOM   4367 C  CB  . THR D 1 157 ? 55.981  -53.306 11.818  1.00 48.66  ? 152 THR M CB  1 
ATOM   4368 O  OG1 . THR D 1 157 ? 57.035  -53.918 11.065  1.00 54.10  ? 152 THR M OG1 1 
ATOM   4369 C  CG2 . THR D 1 157 ? 54.888  -54.331 12.094  1.00 46.03  ? 152 THR M CG2 1 
ATOM   4370 N  N   . THR D 1 158 ? 53.050  -51.574 11.191  1.00 42.27  ? 153 THR M N   1 
ATOM   4371 C  CA  . THR D 1 158 ? 51.837  -51.108 11.854  1.00 43.77  ? 153 THR M CA  1 
ATOM   4372 C  C   . THR D 1 158 ? 51.544  -51.873 13.151  1.00 45.83  ? 153 THR M C   1 
ATOM   4373 O  O   . THR D 1 158 ? 51.510  -53.099 13.155  1.00 47.39  ? 153 THR M O   1 
ATOM   4374 C  CB  . THR D 1 158 ? 50.627  -51.224 10.922  1.00 44.16  ? 153 THR M CB  1 
ATOM   4375 O  OG1 . THR D 1 158 ? 50.820  -50.365 9.792   1.00 48.10  ? 153 THR M OG1 1 
ATOM   4376 C  CG2 . THR D 1 158 ? 49.344  -50.822 11.653  1.00 43.50  ? 153 THR M CG2 1 
ATOM   4377 N  N   . GLN D 1 159 ? 51.339  -51.141 14.245  1.00 40.65  ? 154 GLN M N   1 
ATOM   4378 C  CA  . GLN D 1 159 ? 50.977  -51.740 15.529  1.00 34.91  ? 154 GLN M CA  1 
ATOM   4379 C  C   . GLN D 1 159 ? 49.491  -52.057 15.583  1.00 41.34  ? 154 GLN M C   1 
ATOM   4380 O  O   . GLN D 1 159 ? 48.676  -51.322 15.041  1.00 42.35  ? 154 GLN M O   1 
ATOM   4381 C  CB  . GLN D 1 159 ? 51.338  -50.802 16.682  1.00 38.66  ? 154 GLN M CB  1 
ATOM   4382 C  CG  . GLN D 1 159 ? 52.810  -50.462 16.749  1.00 33.04  ? 154 GLN M CG  1 
ATOM   4383 C  CD  . GLN D 1 159 ? 53.670  -51.692 16.942  1.00 35.36  ? 154 GLN M CD  1 
ATOM   4384 O  OE1 . GLN D 1 159 ? 53.784  -52.212 18.049  1.00 36.34  ? 154 GLN M OE1 1 
ATOM   4385 N  NE2 . GLN D 1 159 ? 54.272  -52.171 15.861  1.00 42.83  ? 154 GLN M NE2 1 
ATOM   4386 N  N   . THR D 1 160 ? 49.143  -53.149 16.254  1.00 37.70  ? 155 THR M N   1 
ATOM   4387 C  CA  . THR D 1 160 ? 47.758  -53.599 16.310  1.00 43.58  ? 155 THR M CA  1 
ATOM   4388 C  C   . THR D 1 160 ? 47.312  -53.859 17.744  1.00 47.91  ? 155 THR M C   1 
ATOM   4389 O  O   . THR D 1 160 ? 46.183  -54.288 17.980  1.00 45.84  ? 155 THR M O   1 
ATOM   4390 C  CB  . THR D 1 160 ? 47.549  -54.883 15.479  1.00 44.99  ? 155 THR M CB  1 
ATOM   4391 O  OG1 . THR D 1 160 ? 48.547  -55.849 15.829  1.00 44.42  ? 155 THR M OG1 1 
ATOM   4392 C  CG2 . THR D 1 160 ? 47.664  -54.586 14.001  1.00 48.50  ? 155 THR M CG2 1 
ATOM   4393 N  N   . THR D 1 161 ? 48.201  -53.598 18.699  1.00 36.21  ? 156 THR M N   1 
ATOM   4394 C  CA  . THR D 1 161 ? 47.880  -53.803 20.105  1.00 34.55  ? 156 THR M CA  1 
ATOM   4395 C  C   . THR D 1 161 ? 48.612  -52.786 20.991  1.00 35.05  ? 156 THR M C   1 
ATOM   4396 O  O   . THR D 1 161 ? 49.578  -52.162 20.554  1.00 39.21  ? 156 THR M O   1 
ATOM   4397 C  CB  . THR D 1 161 ? 48.250  -55.234 20.528  1.00 43.62  ? 156 THR M CB  1 
ATOM   4398 O  OG1 . THR D 1 161 ? 47.707  -55.510 21.827  1.00 52.13  ? 156 THR M OG1 1 
ATOM   4399 C  CG2 . THR D 1 161 ? 49.758  -55.407 20.549  1.00 34.77  ? 156 THR M CG2 1 
ATOM   4400 N  N   . GLY D 1 162 ? 48.148  -52.619 22.225  1.00 27.00  ? 157 GLY M N   1 
ATOM   4401 C  CA  . GLY D 1 162 ? 48.762  -51.692 23.161  1.00 34.42  ? 157 GLY M CA  1 
ATOM   4402 C  C   . GLY D 1 162 ? 48.391  -50.221 22.963  1.00 33.70  ? 157 GLY M C   1 
ATOM   4403 O  O   . GLY D 1 162 ? 49.047  -49.330 23.497  1.00 29.24  ? 157 GLY M O   1 
ATOM   4404 N  N   . ILE D 1 163 ? 47.323  -49.964 22.217  1.00 31.40  ? 158 ILE M N   1 
ATOM   4405 C  CA  . ILE D 1 163 ? 46.937  -48.595 21.899  1.00 28.55  ? 158 ILE M CA  1 
ATOM   4406 C  C   . ILE D 1 163 ? 45.654  -48.157 22.608  1.00 35.10  ? 158 ILE M C   1 
ATOM   4407 O  O   . ILE D 1 163 ? 44.691  -48.918 22.692  1.00 33.36  ? 158 ILE M O   1 
ATOM   4408 C  CB  . ILE D 1 163 ? 46.771  -48.420 20.389  1.00 32.36  ? 158 ILE M CB  1 
ATOM   4409 C  CG1 . ILE D 1 163 ? 48.074  -48.777 19.677  1.00 30.84  ? 158 ILE M CG1 1 
ATOM   4410 C  CG2 . ILE D 1 163 ? 46.367  -46.991 20.047  1.00 32.94  ? 158 ILE M CG2 1 
ATOM   4411 C  CD1 . ILE D 1 163 ? 47.911  -48.934 18.191  1.00 31.48  ? 158 ILE M CD1 1 
ATOM   4412 N  N   . GLU D 1 164 ? 45.651  -46.916 23.097  1.00 28.83  ? 159 GLU M N   1 
ATOM   4413 C  CA  . GLU D 1 164 ? 44.524  -46.364 23.839  1.00 29.85  ? 159 GLU M CA  1 
ATOM   4414 C  C   . GLU D 1 164 ? 44.272  -44.905 23.414  1.00 31.17  ? 159 GLU M C   1 
ATOM   4415 O  O   . GLU D 1 164 ? 45.173  -44.067 23.496  1.00 21.83  ? 159 GLU M O   1 
ATOM   4416 C  CB  . GLU D 1 164 ? 44.859  -46.394 25.327  1.00 27.28  ? 159 GLU M CB  1 
ATOM   4417 C  CG  . GLU D 1 164 ? 43.674  -46.422 26.242  1.00 43.87  ? 159 GLU M CG  1 
ATOM   4418 C  CD  . GLU D 1 164 ? 43.177  -47.836 26.476  1.00 59.79  ? 159 GLU M CD  1 
ATOM   4419 O  OE1 . GLU D 1 164 ? 42.097  -48.190 25.944  1.00 58.24  ? 159 GLU M OE1 1 
ATOM   4420 O  OE2 . GLU D 1 164 ? 43.873  -48.591 27.189  1.00 57.38  ? 159 GLU M OE2 1 
ATOM   4421 N  N   . ASN D 1 165 ? 43.048  -44.602 22.991  1.00 27.21  ? 160 ASN M N   1 
ATOM   4422 C  CA  . ASN D 1 165 ? 42.680  -43.251 22.573  1.00 26.20  ? 160 ASN M CA  1 
ATOM   4423 C  C   . ASN D 1 165 ? 41.706  -42.543 23.530  1.00 25.58  ? 160 ASN M C   1 
ATOM   4424 O  O   . ASN D 1 165 ? 40.781  -43.152 24.071  1.00 26.87  ? 160 ASN M O   1 
ATOM   4425 C  CB  . ASN D 1 165 ? 42.103  -43.264 21.150  1.00 24.77  ? 160 ASN M CB  1 
ATOM   4426 C  CG  . ASN D 1 165 ? 43.090  -43.804 20.115  1.00 35.01  ? 160 ASN M CG  1 
ATOM   4427 O  OD1 . ASN D 1 165 ? 44.297  -43.662 20.261  1.00 27.60  ? 160 ASN M OD1 1 
ATOM   4428 N  ND2 . ASN D 1 165 ? 42.569  -44.418 19.060  1.00 32.59  ? 160 ASN M ND2 1 
ATOM   4429 N  N   . SER D 1 166 ? 41.913  -41.250 23.719  1.00 19.37  ? 161 SER M N   1 
ATOM   4430 C  CA  . SER D 1 166 ? 41.028  -40.432 24.536  1.00 21.52  ? 161 SER M CA  1 
ATOM   4431 C  C   . SER D 1 166 ? 40.772  -39.069 23.874  1.00 24.86  ? 161 SER M C   1 
ATOM   4432 O  O   . SER D 1 166 ? 41.706  -38.330 23.586  1.00 20.20  ? 161 SER M O   1 
ATOM   4433 C  CB  . SER D 1 166 ? 41.627  -40.240 25.924  1.00 24.31  ? 161 SER M CB  1 
ATOM   4434 O  OG  . SER D 1 166 ? 40.745  -39.501 26.743  1.00 24.65  ? 161 SER M OG  1 
ATOM   4435 N  N   . LYS D 1 167 ? 39.499  -38.746 23.648  1.00 22.61  ? 162 LYS M N   1 
ATOM   4436 C  CA  . LYS D 1 167 ? 39.088  -37.536 22.923  1.00 22.28  ? 162 LYS M CA  1 
ATOM   4437 C  C   . LYS D 1 167 ? 38.339  -36.557 23.838  1.00 25.27  ? 162 LYS M C   1 
ATOM   4438 O  O   . LYS D 1 167 ? 37.480  -36.967 24.630  1.00 22.90  ? 162 LYS M O   1 
ATOM   4439 C  CB  . LYS D 1 167 ? 38.210  -37.947 21.732  1.00 22.00  ? 162 LYS M CB  1 
ATOM   4440 C  CG  . LYS D 1 167 ? 37.941  -36.852 20.719  1.00 22.31  ? 162 LYS M CG  1 
ATOM   4441 C  CD  . LYS D 1 167 ? 37.274  -37.411 19.453  1.00 23.37  ? 162 LYS M CD  1 
ATOM   4442 C  CE  . LYS D 1 167 ? 35.813  -37.795 19.704  1.00 26.95  ? 162 LYS M CE  1 
ATOM   4443 N  NZ  . LYS D 1 167 ? 35.171  -38.374 18.480  1.00 24.94  ? 162 LYS M NZ  1 
ATOM   4444 N  N   . THR D 1 168 ? 38.673  -35.269 23.744  1.00 17.46  ? 163 THR M N   1 
ATOM   4445 C  CA  . THR D 1 168 ? 38.028  -34.229 24.557  1.00 21.01  ? 163 THR M CA  1 
ATOM   4446 C  C   . THR D 1 168 ? 36.594  -33.940 24.075  1.00 23.17  ? 163 THR M C   1 
ATOM   4447 O  O   . THR D 1 168 ? 36.201  -34.381 22.999  1.00 19.98  ? 163 THR M O   1 
ATOM   4448 C  CB  . THR D 1 168 ? 38.811  -32.902 24.489  1.00 23.29  ? 163 THR M CB  1 
ATOM   4449 O  OG1 . THR D 1 168 ? 38.816  -32.410 23.140  1.00 27.56  ? 163 THR M OG1 1 
ATOM   4450 C  CG2 . THR D 1 168 ? 40.246  -33.077 24.995  1.00 23.19  ? 163 THR M CG2 1 
ATOM   4451 N  N   . PRO D 1 169 ? 35.802  -33.217 24.882  1.00 21.52  ? 164 PRO M N   1 
ATOM   4452 C  CA  . PRO D 1 169 ? 34.519  -32.720 24.352  1.00 25.18  ? 164 PRO M CA  1 
ATOM   4453 C  C   . PRO D 1 169 ? 34.758  -31.672 23.268  1.00 28.99  ? 164 PRO M C   1 
ATOM   4454 O  O   . PRO D 1 169 ? 35.866  -31.131 23.170  1.00 19.91  ? 164 PRO M O   1 
ATOM   4455 C  CB  . PRO D 1 169 ? 33.859  -32.063 25.572  1.00 26.46  ? 164 PRO M CB  1 
ATOM   4456 C  CG  . PRO D 1 169 ? 34.487  -32.762 26.762  1.00 28.95  ? 164 PRO M CG  1 
ATOM   4457 C  CD  . PRO D 1 169 ? 35.925  -32.989 26.337  1.00 25.18  ? 164 PRO M CD  1 
ATOM   4458 N  N   . GLN D 1 170 ? 33.742  -31.402 22.456  1.00 18.56  ? 165 GLN M N   1 
ATOM   4459 C  CA  . GLN D 1 170 ? 33.857  -30.390 21.408  1.00 18.09  ? 165 GLN M CA  1 
ATOM   4460 C  C   . GLN D 1 170 ? 34.094  -29.010 21.998  1.00 21.33  ? 165 GLN M C   1 
ATOM   4461 O  O   . GLN D 1 170 ? 33.505  -28.660 23.006  1.00 22.02  ? 165 GLN M O   1 
ATOM   4462 C  CB  . GLN D 1 170 ? 32.582  -30.370 20.554  1.00 16.97  ? 165 GLN M CB  1 
ATOM   4463 C  CG  . GLN D 1 170 ? 32.349  -31.667 19.752  1.00 16.64  ? 165 GLN M CG  1 
ATOM   4464 C  CD  . GLN D 1 170 ? 31.217  -31.521 18.738  1.00 20.20  ? 165 GLN M CD  1 
ATOM   4465 O  OE1 . GLN D 1 170 ? 30.096  -31.927 19.001  1.00 19.23  ? 165 GLN M OE1 1 
ATOM   4466 N  NE2 . GLN D 1 170 ? 31.512  -30.908 17.585  1.00 19.90  ? 165 GLN M NE2 1 
ATOM   4467 N  N   . ASN D 1 171 ? 34.957  -28.228 21.354  1.00 23.11  ? 166 ASN M N   1 
ATOM   4468 C  CA  . ASN D 1 171 ? 35.170  -26.829 21.726  1.00 24.65  ? 166 ASN M CA  1 
ATOM   4469 C  C   . ASN D 1 171 ? 33.911  -25.989 21.544  1.00 25.52  ? 166 ASN M C   1 
ATOM   4470 O  O   . ASN D 1 171 ? 33.297  -26.026 20.490  1.00 22.00  ? 166 ASN M O   1 
ATOM   4471 C  CB  . ASN D 1 171 ? 36.306  -26.231 20.894  1.00 22.16  ? 166 ASN M CB  1 
ATOM   4472 C  CG  . ASN D 1 171 ? 36.683  -24.822 21.345  1.00 32.16  ? 166 ASN M CG  1 
ATOM   4473 O  OD1 . ASN D 1 171 ? 36.088  -23.844 20.913  1.00 26.63  ? 166 ASN M OD1 1 
ATOM   4474 N  ND2 . ASN D 1 171 ? 37.689  -24.721 22.209  1.00 31.61  ? 166 ASN M ND2 1 
ATOM   4475 N  N   . SER D 1 172 ? 33.544  -25.214 22.559  1.00 26.71  ? 167 SER M N   1 
ATOM   4476 C  CA  . SER D 1 172 ? 32.288  -24.462 22.519  1.00 26.32  ? 167 SER M CA  1 
ATOM   4477 C  C   . SER D 1 172 ? 32.315  -23.322 21.507  1.00 25.73  ? 167 SER M C   1 
ATOM   4478 O  O   . SER D 1 172 ? 31.273  -22.799 21.126  1.00 31.91  ? 167 SER M O   1 
ATOM   4479 C  CB  . SER D 1 172 ? 31.926  -23.934 23.909  1.00 31.38  ? 167 SER M CB  1 
ATOM   4480 O  OG  . SER D 1 172 ? 32.841  -22.944 24.325  1.00 46.80  ? 167 SER M OG  1 
ATOM   4481 N  N   . ALA D 1 173 ? 33.506  -22.953 21.049  1.00 23.81  ? 168 ALA M N   1 
ATOM   4482 C  CA  . ALA D 1 173 ? 33.620  -21.890 20.051  1.00 26.96  ? 168 ALA M CA  1 
ATOM   4483 C  C   . ALA D 1 173 ? 33.642  -22.363 18.597  1.00 33.63  ? 168 ALA M C   1 
ATOM   4484 O  O   . ALA D 1 173 ? 32.988  -21.755 17.745  1.00 31.83  ? 168 ALA M O   1 
ATOM   4485 C  CB  . ALA D 1 173 ? 34.827  -21.004 20.337  1.00 33.67  ? 168 ALA M CB  1 
ATOM   4486 N  N   . ASP D 1 174 ? 34.388  -23.432 18.302  1.00 23.07  ? 169 ASP M N   1 
ATOM   4487 C  CA  . ASP D 1 174 ? 34.557  -23.850 16.908  1.00 23.82  ? 169 ASP M CA  1 
ATOM   4488 C  C   . ASP D 1 174 ? 34.303  -25.335 16.627  1.00 21.90  ? 169 ASP M C   1 
ATOM   4489 O  O   . ASP D 1 174 ? 34.630  -25.810 15.549  1.00 21.27  ? 169 ASP M O   1 
ATOM   4490 C  CB  . ASP D 1 174 ? 35.945  -23.453 16.392  1.00 22.45  ? 169 ASP M CB  1 
ATOM   4491 C  CG  . ASP D 1 174 ? 37.076  -24.178 17.118  1.00 30.82  ? 169 ASP M CG  1 
ATOM   4492 O  OD1 . ASP D 1 174 ? 38.241  -23.800 16.898  1.00 30.67  ? 169 ASP M OD1 1 
ATOM   4493 O  OD2 . ASP D 1 174 ? 36.821  -25.128 17.898  1.00 23.45  ? 169 ASP M OD2 1 
ATOM   4494 N  N   . CYS D 1 175 ? 33.752  -26.054 17.604  1.00 19.83  ? 170 CYS M N   1 
ATOM   4495 C  CA  . CYS D 1 175 ? 33.361  -27.458 17.429  1.00 20.07  ? 170 CYS M CA  1 
ATOM   4496 C  C   . CYS D 1 175 ? 34.538  -28.448 17.390  1.00 18.88  ? 170 CYS M C   1 
ATOM   4497 O  O   . CYS D 1 175 ? 34.320  -29.658 17.298  1.00 19.52  ? 170 CYS M O   1 
ATOM   4498 C  CB  . CYS D 1 175 ? 32.456  -27.641 16.183  1.00 16.87  ? 170 CYS M CB  1 
ATOM   4499 S  SG  . CYS D 1 175 ? 30.738  -26.977 16.291  1.00 23.28  ? 170 CYS M SG  1 
ATOM   4500 N  N   . THR D 1 176 ? 35.776  -27.965 17.478  1.00 19.71  ? 171 THR M N   1 
ATOM   4501 C  CA  . THR D 1 176 ? 36.931  -28.865 17.328  1.00 19.88  ? 171 THR M CA  1 
ATOM   4502 C  C   . THR D 1 176 ? 37.168  -29.817 18.501  1.00 19.59  ? 171 THR M C   1 
ATOM   4503 O  O   . THR D 1 176 ? 36.785  -29.547 19.639  1.00 20.02  ? 171 THR M O   1 
ATOM   4504 C  CB  . THR D 1 176 ? 38.264  -28.121 17.038  1.00 17.99  ? 171 THR M CB  1 
ATOM   4505 O  OG1 . THR D 1 176 ? 38.506  -27.155 18.075  1.00 19.55  ? 171 THR M OG1 1 
ATOM   4506 C  CG2 . THR D 1 176 ? 38.219  -27.439 15.678  1.00 19.49  ? 171 THR M CG2 1 
ATOM   4507 N  N   . TYR D 1 177 ? 37.814  -30.938 18.187  1.00 20.39  ? 172 TYR M N   1 
ATOM   4508 C  CA  . TYR D 1 177 ? 38.216  -31.943 19.163  1.00 18.65  ? 172 TYR M CA  1 
ATOM   4509 C  C   . TYR D 1 177 ? 39.706  -31.829 19.420  1.00 20.92  ? 172 TYR M C   1 
ATOM   4510 O  O   . TYR D 1 177 ? 40.439  -31.190 18.651  1.00 16.46  ? 172 TYR M O   1 
ATOM   4511 C  CB  . TYR D 1 177 ? 37.967  -33.351 18.610  1.00 16.08  ? 172 TYR M CB  1 
ATOM   4512 C  CG  . TYR D 1 177 ? 36.530  -33.745 18.444  1.00 22.04  ? 172 TYR M CG  1 
ATOM   4513 C  CD1 . TYR D 1 177 ? 35.984  -33.949 17.176  1.00 22.56  ? 172 TYR M CD1 1 
ATOM   4514 C  CD2 . TYR D 1 177 ? 35.707  -33.934 19.556  1.00 17.61  ? 172 TYR M CD2 1 
ATOM   4515 C  CE1 . TYR D 1 177 ? 34.655  -34.334 17.026  1.00 20.57  ? 172 TYR M CE1 1 
ATOM   4516 C  CE2 . TYR D 1 177 ? 34.403  -34.319 19.406  1.00 16.03  ? 172 TYR M CE2 1 
ATOM   4517 C  CZ  . TYR D 1 177 ? 33.875  -34.507 18.154  1.00 20.77  ? 172 TYR M CZ  1 
ATOM   4518 O  OH  . TYR D 1 177 ? 32.555  -34.878 18.044  1.00 24.23  ? 172 TYR M OH  1 
ATOM   4519 N  N   . ASN D 1 178 ? 40.150  -32.471 20.495  1.00 20.79  ? 173 ASN M N   1 
ATOM   4520 C  CA  . ASN D 1 178 ? 41.562  -32.791 20.683  1.00 17.79  ? 173 ASN M CA  1 
ATOM   4521 C  C   . ASN D 1 178 ? 41.639  -34.280 21.043  1.00 21.52  ? 173 ASN M C   1 
ATOM   4522 O  O   . ASN D 1 178 ? 40.702  -34.824 21.640  1.00 18.03  ? 173 ASN M O   1 
ATOM   4523 C  CB  . ASN D 1 178 ? 42.181  -31.957 21.787  1.00 16.18  ? 173 ASN M CB  1 
ATOM   4524 C  CG  . ASN D 1 178 ? 42.092  -30.460 21.516  1.00 25.62  ? 173 ASN M CG  1 
ATOM   4525 O  OD1 . ASN D 1 178 ? 42.948  -29.888 20.846  1.00 17.13  ? 173 ASN M OD1 1 
ATOM   4526 N  ND2 . ASN D 1 178 ? 41.058  -29.823 22.047  1.00 21.14  ? 173 ASN M ND2 1 
ATOM   4527 N  N   . LEU D 1 179 ? 42.728  -34.938 20.658  1.00 18.14  ? 174 LEU M N   1 
ATOM   4528 C  CA  . LEU D 1 179 ? 42.878  -36.378 20.875  1.00 18.29  ? 174 LEU M CA  1 
ATOM   4529 C  C   . LEU D 1 179 ? 44.243  -36.765 21.430  1.00 21.95  ? 174 LEU M C   1 
ATOM   4530 O  O   . LEU D 1 179 ? 45.267  -36.283 20.953  1.00 21.01  ? 174 LEU M O   1 
ATOM   4531 C  CB  . LEU D 1 179 ? 42.659  -37.131 19.568  1.00 21.55  ? 174 LEU M CB  1 
ATOM   4532 C  CG  . LEU D 1 179 ? 42.721  -38.658 19.693  1.00 24.91  ? 174 LEU M CG  1 
ATOM   4533 C  CD1 . LEU D 1 179 ? 41.422  -39.186 20.257  1.00 30.66  ? 174 LEU M CD1 1 
ATOM   4534 C  CD2 . LEU D 1 179 ? 43.004  -39.297 18.363  1.00 31.68  ? 174 LEU M CD2 1 
ATOM   4535 N  N   . SER D 1 180 ? 44.264  -37.635 22.440  1.00 17.09  ? 175 SER M N   1 
ATOM   4536 C  CA  . SER D 1 180 ? 45.526  -38.225 22.872  1.00 20.90  ? 175 SER M CA  1 
ATOM   4537 C  C   . SER D 1 180 ? 45.510  -39.702 22.492  1.00 23.54  ? 175 SER M C   1 
ATOM   4538 O  O   . SER D 1 180 ? 44.515  -40.386 22.708  1.00 25.42  ? 175 SER M O   1 
ATOM   4539 C  CB  . SER D 1 180 ? 45.724  -38.082 24.373  1.00 23.83  ? 175 SER M CB  1 
ATOM   4540 O  OG  . SER D 1 180 ? 44.852  -38.955 25.067  1.00 25.14  ? 175 SER M OG  1 
ATOM   4541 N  N   . SER D 1 181 ? 46.589  -40.183 21.889  1.00 22.42  ? 176 SER M N   1 
ATOM   4542 C  CA  . SER D 1 181 ? 46.719  -41.607 21.606  1.00 23.91  ? 176 SER M CA  1 
ATOM   4543 C  C   . SER D 1 181 ? 48.021  -42.097 22.235  1.00 30.11  ? 176 SER M C   1 
ATOM   4544 O  O   . SER D 1 181 ? 49.069  -41.483 22.040  1.00 25.12  ? 176 SER M O   1 
ATOM   4545 C  CB  . SER D 1 181 ? 46.711  -41.866 20.098  1.00 21.27  ? 176 SER M CB  1 
ATOM   4546 O  OG  . SER D 1 181 ? 46.827  -43.259 19.796  1.00 24.36  ? 176 SER M OG  1 
ATOM   4547 N  N   . THR D 1 182 ? 47.954  -43.181 23.008  1.00 23.33  ? 177 THR M N   1 
ATOM   4548 C  CA  . THR D 1 182 ? 49.151  -43.715 23.663  1.00 24.88  ? 177 THR M CA  1 
ATOM   4549 C  C   . THR D 1 182 ? 49.478  -45.127 23.193  1.00 31.52  ? 177 THR M C   1 
ATOM   4550 O  O   . THR D 1 182 ? 48.581  -45.950 23.015  1.00 38.27  ? 177 THR M O   1 
ATOM   4551 C  CB  . THR D 1 182 ? 48.985  -43.744 25.171  1.00 31.67  ? 177 THR M CB  1 
ATOM   4552 O  OG1 . THR D 1 182 ? 47.933  -44.657 25.504  1.00 34.72  ? 177 THR M OG1 1 
ATOM   4553 C  CG2 . THR D 1 182 ? 48.627  -42.352 25.680  1.00 25.19  ? 177 THR M CG2 1 
ATOM   4554 N  N   . LEU D 1 183 ? 50.762  -45.391 22.973  1.00 29.05  ? 178 LEU M N   1 
ATOM   4555 C  CA  . LEU D 1 183 ? 51.247  -46.738 22.652  1.00 24.43  ? 178 LEU M CA  1 
ATOM   4556 C  C   . LEU D 1 183 ? 52.097  -47.245 23.813  1.00 33.02  ? 178 LEU M C   1 
ATOM   4557 O  O   . LEU D 1 183 ? 53.062  -46.586 24.231  1.00 29.76  ? 178 LEU M O   1 
ATOM   4558 C  CB  . LEU D 1 183 ? 52.085  -46.731 21.374  1.00 27.82  ? 178 LEU M CB  1 
ATOM   4559 C  CG  . LEU D 1 183 ? 52.769  -48.053 21.014  1.00 30.65  ? 178 LEU M CG  1 
ATOM   4560 C  CD1 . LEU D 1 183 ? 51.729  -49.108 20.669  1.00 31.25  ? 178 LEU M CD1 1 
ATOM   4561 C  CD2 . LEU D 1 183 ? 53.733  -47.856 19.859  1.00 28.40  ? 178 LEU M CD2 1 
ATOM   4562 N  N   . THR D 1 184 ? 51.726  -48.412 24.337  1.00 25.99  ? 179 THR M N   1 
ATOM   4563 C  CA  . THR D 1 184 ? 52.415  -48.996 25.483  1.00 33.42  ? 179 THR M CA  1 
ATOM   4564 C  C   . THR D 1 184 ? 53.177  -50.285 25.123  1.00 29.51  ? 179 THR M C   1 
ATOM   4565 O  O   . THR D 1 184 ? 52.623  -51.184 24.506  1.00 30.28  ? 179 THR M O   1 
ATOM   4566 C  CB  . THR D 1 184 ? 51.420  -49.275 26.611  1.00 33.98  ? 179 THR M CB  1 
ATOM   4567 O  OG1 . THR D 1 184 ? 50.741  -48.056 26.946  1.00 36.07  ? 179 THR M OG1 1 
ATOM   4568 C  CG2 . THR D 1 184 ? 52.135  -49.825 27.839  1.00 33.14  ? 179 THR M CG2 1 
ATOM   4569 N  N   . LEU D 1 185 ? 54.445  -50.354 25.519  1.00 32.55  ? 180 LEU M N   1 
ATOM   4570 C  CA  . LEU D 1 185 ? 55.302  -51.501 25.223  1.00 33.46  ? 180 LEU M CA  1 
ATOM   4571 C  C   . LEU D 1 185 ? 56.143  -51.844 26.441  1.00 39.38  ? 180 LEU M C   1 
ATOM   4572 O  O   . LEU D 1 185 ? 56.294  -51.022 27.353  1.00 32.56  ? 180 LEU M O   1 
ATOM   4573 C  CB  . LEU D 1 185 ? 56.262  -51.178 24.079  1.00 34.80  ? 180 LEU M CB  1 
ATOM   4574 C  CG  . LEU D 1 185 ? 55.755  -50.750 22.704  1.00 39.84  ? 180 LEU M CG  1 
ATOM   4575 C  CD1 . LEU D 1 185 ? 56.930  -50.225 21.897  1.00 42.99  ? 180 LEU M CD1 1 
ATOM   4576 C  CD2 . LEU D 1 185 ? 55.079  -51.906 21.981  1.00 42.89  ? 180 LEU M CD2 1 
ATOM   4577 N  N   . THR D 1 186 ? 56.711  -53.049 26.449  1.00 29.10  ? 181 THR M N   1 
ATOM   4578 C  CA  . THR D 1 186 ? 57.669  -53.404 27.488  1.00 40.29  ? 181 THR M CA  1 
ATOM   4579 C  C   . THR D 1 186 ? 58.962  -52.664 27.175  1.00 26.65  ? 181 THR M C   1 
ATOM   4580 O  O   . THR D 1 186 ? 59.183  -52.256 26.042  1.00 35.52  ? 181 THR M O   1 
ATOM   4581 C  CB  . THR D 1 186 ? 57.953  -54.915 27.523  1.00 33.77  ? 181 THR M CB  1 
ATOM   4582 O  OG1 . THR D 1 186 ? 58.703  -55.284 26.357  1.00 38.16  ? 181 THR M OG1 1 
ATOM   4583 C  CG2 . THR D 1 186 ? 56.650  -55.701 27.576  1.00 35.30  ? 181 THR M CG2 1 
ATOM   4584 N  N   . SER D 1 187 ? 59.804  -52.471 28.182  1.00 37.30  ? 182 SER M N   1 
ATOM   4585 C  CA  . SER D 1 187 ? 61.104  -51.851 27.964  1.00 34.23  ? 182 SER M CA  1 
ATOM   4586 C  C   . SER D 1 187 ? 61.945  -52.678 27.004  1.00 43.02  ? 182 SER M C   1 
ATOM   4587 O  O   . SER D 1 187 ? 62.660  -52.129 26.163  1.00 47.07  ? 182 SER M O   1 
ATOM   4588 C  CB  . SER D 1 187 ? 61.834  -51.665 29.287  1.00 46.16  ? 182 SER M CB  1 
ATOM   4589 O  OG  . SER D 1 187 ? 61.099  -50.809 30.140  1.00 39.93  ? 182 SER M OG  1 
ATOM   4590 N  N   . THR D 1 188 ? 61.842  -54.000 27.125  1.00 43.81  ? 183 THR M N   1 
ATOM   4591 C  CA  . THR D 1 188 ? 62.549  -54.915 26.243  1.00 40.94  ? 183 THR M CA  1 
ATOM   4592 C  C   . THR D 1 188 ? 62.168  -54.641 24.799  1.00 43.39  ? 183 THR M C   1 
ATOM   4593 O  O   . THR D 1 188 ? 63.036  -54.482 23.938  1.00 47.02  ? 183 THR M O   1 
ATOM   4594 C  CB  . THR D 1 188 ? 62.234  -56.382 26.603  1.00 45.02  ? 183 THR M CB  1 
ATOM   4595 O  OG1 . THR D 1 188 ? 62.748  -56.665 27.909  1.00 52.90  ? 183 THR M OG1 1 
ATOM   4596 C  CG2 . THR D 1 188 ? 62.852  -57.334 25.597  1.00 46.16  ? 183 THR M CG2 1 
ATOM   4597 N  N   . GLN D 1 189 ? 60.866  -54.568 24.542  1.00 42.57  ? 184 GLN M N   1 
ATOM   4598 C  CA  . GLN D 1 189 ? 60.362  -54.281 23.204  1.00 34.87  ? 184 GLN M CA  1 
ATOM   4599 C  C   . GLN D 1 189 ? 60.854  -52.929 22.713  1.00 39.44  ? 184 GLN M C   1 
ATOM   4600 O  O   . GLN D 1 189 ? 61.364  -52.813 21.598  1.00 43.79  ? 184 GLN M O   1 
ATOM   4601 C  CB  . GLN D 1 189 ? 58.830  -54.302 23.193  1.00 40.55  ? 184 GLN M CB  1 
ATOM   4602 C  CG  . GLN D 1 189 ? 58.218  -55.690 23.213  1.00 45.20  ? 184 GLN M CG  1 
ATOM   4603 C  CD  . GLN D 1 189 ? 56.708  -55.643 23.302  1.00 50.62  ? 184 GLN M CD  1 
ATOM   4604 O  OE1 . GLN D 1 189 ? 56.143  -54.786 23.986  1.00 41.56  ? 184 GLN M OE1 1 
ATOM   4605 N  NE2 . GLN D 1 189 ? 56.043  -56.559 22.602  1.00 53.86  ? 184 GLN M NE2 1 
ATOM   4606 N  N   . TYR D 1 190 ? 60.698  -51.910 23.557  1.00 41.78  ? 185 TYR M N   1 
ATOM   4607 C  CA  . TYR D 1 190 ? 61.060  -50.542 23.204  1.00 39.00  ? 185 TYR M CA  1 
ATOM   4608 C  C   . TYR D 1 190 ? 62.537  -50.456 22.845  1.00 44.27  ? 185 TYR M C   1 
ATOM   4609 O  O   . TYR D 1 190 ? 62.914  -49.842 21.847  1.00 36.92  ? 185 TYR M O   1 
ATOM   4610 C  CB  . TYR D 1 190 ? 60.740  -49.582 24.355  1.00 40.74  ? 185 TYR M CB  1 
ATOM   4611 C  CG  . TYR D 1 190 ? 61.106  -48.132 24.083  1.00 37.55  ? 185 TYR M CG  1 
ATOM   4612 C  CD1 . TYR D 1 190 ? 60.477  -47.414 23.069  1.00 32.22  ? 185 TYR M CD1 1 
ATOM   4613 C  CD2 . TYR D 1 190 ? 62.075  -47.484 24.842  1.00 35.09  ? 185 TYR M CD2 1 
ATOM   4614 C  CE1 . TYR D 1 190 ? 60.806  -46.091 22.810  1.00 35.57  ? 185 TYR M CE1 1 
ATOM   4615 C  CE2 . TYR D 1 190 ? 62.413  -46.163 24.598  1.00 35.16  ? 185 TYR M CE2 1 
ATOM   4616 C  CZ  . TYR D 1 190 ? 61.774  -45.469 23.582  1.00 36.80  ? 185 TYR M CZ  1 
ATOM   4617 O  OH  . TYR D 1 190 ? 62.098  -44.156 23.332  1.00 33.41  ? 185 TYR M OH  1 
ATOM   4618 N  N   . ASN D 1 191 ? 63.369  -51.101 23.648  1.00 46.09  ? 186 ASN M N   1 
ATOM   4619 C  CA  . ASN D 1 191 ? 64.808  -51.065 23.415  1.00 52.29  ? 186 ASN M CA  1 
ATOM   4620 C  C   . ASN D 1 191 ? 65.257  -51.801 22.154  1.00 51.72  ? 186 ASN M C   1 
ATOM   4621 O  O   . ASN D 1 191 ? 66.384  -51.606 21.688  1.00 53.99  ? 186 ASN M O   1 
ATOM   4622 C  CB  . ASN D 1 191 ? 65.572  -51.561 24.647  1.00 49.31  ? 186 ASN M CB  1 
ATOM   4623 C  CG  . ASN D 1 191 ? 65.663  -50.506 25.729  1.00 53.63  ? 186 ASN M CG  1 
ATOM   4624 O  OD1 . ASN D 1 191 ? 65.555  -49.309 25.447  1.00 53.07  ? 186 ASN M OD1 1 
ATOM   4625 N  ND2 . ASN D 1 191 ? 65.862  -50.937 26.972  1.00 51.88  ? 186 ASN M ND2 1 
ATOM   4626 N  N   . SER D 1 192 ? 64.379  -52.623 21.587  1.00 45.13  ? 187 SER M N   1 
ATOM   4627 C  CA  . SER D 1 192 ? 64.755  -53.409 20.415  1.00 44.81  ? 187 SER M CA  1 
ATOM   4628 C  C   . SER D 1 192 ? 64.294  -52.783 19.104  1.00 50.28  ? 187 SER M C   1 
ATOM   4629 O  O   . SER D 1 192 ? 64.351  -53.420 18.046  1.00 45.94  ? 187 SER M O   1 
ATOM   4630 C  CB  . SER D 1 192 ? 64.229  -54.844 20.530  1.00 49.69  ? 187 SER M CB  1 
ATOM   4631 O  OG  . SER D 1 192 ? 62.867  -54.919 20.151  1.00 59.75  ? 187 SER M OG  1 
ATOM   4632 N  N   . HIS D 1 193 ? 63.843  -51.533 19.160  1.00 43.43  ? 188 HIS M N   1 
ATOM   4633 C  CA  . HIS D 1 193 ? 63.468  -50.838 17.936  1.00 38.16  ? 188 HIS M CA  1 
ATOM   4634 C  C   . HIS D 1 193 ? 63.957  -49.395 17.857  1.00 35.75  ? 188 HIS M C   1 
ATOM   4635 O  O   . HIS D 1 193 ? 64.410  -48.813 18.848  1.00 34.62  ? 188 HIS M O   1 
ATOM   4636 C  CB  . HIS D 1 193 ? 61.964  -50.925 17.700  1.00 42.95  ? 188 HIS M CB  1 
ATOM   4637 C  CG  . HIS D 1 193 ? 61.480  -52.323 17.488  1.00 45.73  ? 188 HIS M CG  1 
ATOM   4638 N  ND1 . HIS D 1 193 ? 61.078  -53.134 18.527  1.00 52.32  ? 188 HIS M ND1 1 
ATOM   4639 C  CD2 . HIS D 1 193 ? 61.367  -53.063 16.364  1.00 46.78  ? 188 HIS M CD2 1 
ATOM   4640 C  CE1 . HIS D 1 193 ? 60.717  -54.311 18.048  1.00 51.57  ? 188 HIS M CE1 1 
ATOM   4641 N  NE2 . HIS D 1 193 ? 60.883  -54.295 16.738  1.00 50.72  ? 188 HIS M NE2 1 
ATOM   4642 N  N   . LYS D 1 194 ? 63.857  -48.824 16.663  1.00 39.27  ? 189 LYS M N   1 
ATOM   4643 C  CA  . LYS D 1 194 ? 64.452  -47.523 16.403  1.00 42.90  ? 189 LYS M CA  1 
ATOM   4644 C  C   . LYS D 1 194 ? 63.440  -46.400 16.176  1.00 31.51  ? 189 LYS M C   1 
ATOM   4645 O  O   . LYS D 1 194 ? 63.416  -45.417 16.914  1.00 33.10  ? 189 LYS M O   1 
ATOM   4646 C  CB  . LYS D 1 194 ? 65.403  -47.604 15.202  1.00 34.20  ? 189 LYS M CB  1 
ATOM   4647 C  CG  . LYS D 1 194 ? 66.203  -46.336 14.967  1.00 43.73  ? 189 LYS M CG  1 
ATOM   4648 C  CD  . LYS D 1 194 ? 66.943  -46.365 13.635  1.00 45.75  ? 189 LYS M CD  1 
ATOM   4649 C  CE  . LYS D 1 194 ? 67.817  -45.127 13.473  1.00 64.64  ? 189 LYS M CE  1 
ATOM   4650 N  NZ  . LYS D 1 194 ? 68.623  -45.151 12.221  1.00 64.34  ? 189 LYS M NZ  1 
ATOM   4651 N  N   . GLU D 1 195 ? 62.634  -46.537 15.132  1.00 33.21  ? 190 GLU M N   1 
ATOM   4652 C  CA  . GLU D 1 195 ? 61.773  -45.449 14.692  1.00 34.95  ? 190 GLU M CA  1 
ATOM   4653 C  C   . GLU D 1 195 ? 60.350  -45.604 15.206  1.00 36.66  ? 190 GLU M C   1 
ATOM   4654 O  O   . GLU D 1 195 ? 59.730  -46.649 15.044  1.00 41.12  ? 190 GLU M O   1 
ATOM   4655 C  CB  . GLU D 1 195 ? 61.758  -45.371 13.168  1.00 36.54  ? 190 GLU M CB  1 
ATOM   4656 C  CG  . GLU D 1 195 ? 61.054  -44.149 12.624  1.00 42.31  ? 190 GLU M CG  1 
ATOM   4657 C  CD  . GLU D 1 195 ? 60.838  -44.227 11.130  1.00 52.73  ? 190 GLU M CD  1 
ATOM   4658 O  OE1 . GLU D 1 195 ? 60.388  -45.287 10.645  1.00 61.10  ? 190 GLU M OE1 1 
ATOM   4659 O  OE2 . GLU D 1 195 ? 61.126  -43.232 10.438  1.00 53.75  ? 190 GLU M OE2 1 
ATOM   4660 N  N   . TYR D 1 196 ? 59.833  -44.549 15.822  1.00 40.71  ? 191 TYR M N   1 
ATOM   4661 C  CA  . TYR D 1 196 ? 58.484  -44.571 16.377  1.00 32.04  ? 191 TYR M CA  1 
ATOM   4662 C  C   . TYR D 1 196 ? 57.634  -43.493 15.730  1.00 34.22  ? 191 TYR M C   1 
ATOM   4663 O  O   . TYR D 1 196 ? 57.941  -42.308 15.827  1.00 27.66  ? 191 TYR M O   1 
ATOM   4664 C  CB  . TYR D 1 196 ? 58.530  -44.422 17.898  1.00 30.21  ? 191 TYR M CB  1 
ATOM   4665 C  CG  . TYR D 1 196 ? 59.122  -45.638 18.571  1.00 35.43  ? 191 TYR M CG  1 
ATOM   4666 C  CD1 . TYR D 1 196 ? 58.308  -46.672 19.010  1.00 33.13  ? 191 TYR M CD1 1 
ATOM   4667 C  CD2 . TYR D 1 196 ? 60.502  -45.768 18.742  1.00 38.17  ? 191 TYR M CD2 1 
ATOM   4668 C  CE1 . TYR D 1 196 ? 58.838  -47.791 19.617  1.00 36.25  ? 191 TYR M CE1 1 
ATOM   4669 C  CE2 . TYR D 1 196 ? 61.043  -46.887 19.346  1.00 34.02  ? 191 TYR M CE2 1 
ATOM   4670 C  CZ  . TYR D 1 196 ? 60.207  -47.900 19.777  1.00 39.79  ? 191 TYR M CZ  1 
ATOM   4671 O  OH  . TYR D 1 196 ? 60.735  -49.017 20.378  1.00 35.39  ? 191 TYR M OH  1 
ATOM   4672 N  N   . THR D 1 197 ? 56.563  -43.912 15.065  1.00 27.81  ? 192 THR M N   1 
ATOM   4673 C  CA  . THR D 1 197 ? 55.805  -43.012 14.208  1.00 30.17  ? 192 THR M CA  1 
ATOM   4674 C  C   . THR D 1 197 ? 54.318  -42.952 14.554  1.00 33.71  ? 192 THR M C   1 
ATOM   4675 O  O   . THR D 1 197 ? 53.666  -43.984 14.712  1.00 27.99  ? 192 THR M O   1 
ATOM   4676 C  CB  . THR D 1 197 ? 55.966  -43.423 12.737  1.00 29.89  ? 192 THR M CB  1 
ATOM   4677 O  OG1 . THR D 1 197 ? 57.332  -43.251 12.349  1.00 35.99  ? 192 THR M OG1 1 
ATOM   4678 C  CG2 . THR D 1 197 ? 55.077  -42.587 11.838  1.00 31.48  ? 192 THR M CG2 1 
ATOM   4679 N  N   . CYS D 1 198 ? 53.788  -41.736 14.673  1.00 27.62  ? 193 CYS M N   1 
ATOM   4680 C  CA  . CYS D 1 198 ? 52.362  -41.535 14.885  1.00 20.44  ? 193 CYS M CA  1 
ATOM   4681 C  C   . CYS D 1 198 ? 51.789  -40.873 13.643  1.00 25.90  ? 193 CYS M C   1 
ATOM   4682 O  O   . CYS D 1 198 ? 52.232  -39.794 13.256  1.00 27.12  ? 193 CYS M O   1 
ATOM   4683 C  CB  . CYS D 1 198 ? 52.119  -40.648 16.108  1.00 22.51  ? 193 CYS M CB  1 
ATOM   4684 S  SG  . CYS D 1 198 ? 50.371  -40.303 16.410  1.00 31.73  ? 193 CYS M SG  1 
ATOM   4685 N  N   . LYS D 1 199 ? 50.812  -41.519 13.013  1.00 23.61  ? 194 LYS M N   1 
ATOM   4686 C  CA  . LYS D 1 199 ? 50.187  -40.972 11.813  1.00 26.17  ? 194 LYS M CA  1 
ATOM   4687 C  C   . LYS D 1 199 ? 48.702  -40.680 12.035  1.00 22.23  ? 194 LYS M C   1 
ATOM   4688 O  O   . LYS D 1 199 ? 47.920  -41.580 12.348  1.00 27.55  ? 194 LYS M O   1 
ATOM   4689 C  CB  . LYS D 1 199 ? 50.363  -41.916 10.616  1.00 23.66  ? 194 LYS M CB  1 
ATOM   4690 C  CG  . LYS D 1 199 ? 49.585  -41.462 9.382   1.00 24.47  ? 194 LYS M CG  1 
ATOM   4691 C  CD  . LYS D 1 199 ? 50.077  -42.114 8.099   1.00 34.32  ? 194 LYS M CD  1 
ATOM   4692 C  CE  . LYS D 1 199 ? 49.594  -43.538 7.958   1.00 43.83  ? 194 LYS M CE  1 
ATOM   4693 N  NZ  . LYS D 1 199 ? 49.914  -44.079 6.604   1.00 54.31  ? 194 LYS M NZ  1 
ATOM   4694 N  N   . VAL D 1 200 ? 48.319  -39.421 11.863  1.00 21.25  ? 195 VAL M N   1 
ATOM   4695 C  CA  . VAL D 1 200 ? 46.942  -38.991 12.114  1.00 19.33  ? 195 VAL M CA  1 
ATOM   4696 C  C   . VAL D 1 200 ? 46.327  -38.645 10.770  1.00 27.99  ? 195 VAL M C   1 
ATOM   4697 O  O   . VAL D 1 200 ? 46.864  -37.818 10.036  1.00 26.21  ? 195 VAL M O   1 
ATOM   4698 C  CB  . VAL D 1 200 ? 46.893  -37.761 13.061  1.00 24.50  ? 195 VAL M CB  1 
ATOM   4699 C  CG1 . VAL D 1 200 ? 45.455  -37.197 13.175  1.00 22.76  ? 195 VAL M CG1 1 
ATOM   4700 C  CG2 . VAL D 1 200 ? 47.440  -38.135 14.446  1.00 19.95  ? 195 VAL M CG2 1 
ATOM   4701 N  N   . THR D 1 201 ? 45.210  -39.290 10.451  1.00 22.54  ? 196 THR M N   1 
ATOM   4702 C  CA  . THR D 1 201 ? 44.609  -39.207 9.127   1.00 25.19  ? 196 THR M CA  1 
ATOM   4703 C  C   . THR D 1 201 ? 43.210  -38.600 9.153   1.00 24.25  ? 196 THR M C   1 
ATOM   4704 O  O   . THR D 1 201 ? 42.342  -39.044 9.902   1.00 25.00  ? 196 THR M O   1 
ATOM   4705 C  CB  . THR D 1 201 ? 44.534  -40.605 8.478   1.00 29.01  ? 196 THR M CB  1 
ATOM   4706 O  OG1 . THR D 1 201 ? 45.863  -41.115 8.319   1.00 24.12  ? 196 THR M OG1 1 
ATOM   4707 C  CG2 . THR D 1 201 ? 43.836  -40.547 7.117   1.00 29.28  ? 196 THR M CG2 1 
ATOM   4708 N  N   . GLN D 1 202 ? 43.009  -37.586 8.322   1.00 23.43  ? 197 GLN M N   1 
ATOM   4709 C  CA  . GLN D 1 202 ? 41.719  -36.944 8.172   1.00 32.37  ? 197 GLN M CA  1 
ATOM   4710 C  C   . GLN D 1 202 ? 41.342  -36.933 6.694   1.00 31.80  ? 197 GLN M C   1 
ATOM   4711 O  O   . GLN D 1 202 ? 41.893  -36.162 5.902   1.00 31.31  ? 197 GLN M O   1 
ATOM   4712 C  CB  . GLN D 1 202 ? 41.790  -35.524 8.724   1.00 28.07  ? 197 GLN M CB  1 
ATOM   4713 C  CG  . GLN D 1 202 ? 40.467  -34.887 8.968   1.00 26.80  ? 197 GLN M CG  1 
ATOM   4714 C  CD  . GLN D 1 202 ? 40.605  -33.457 9.451   1.00 29.91  ? 197 GLN M CD  1 
ATOM   4715 O  OE1 . GLN D 1 202 ? 41.333  -32.656 8.858   1.00 30.53  ? 197 GLN M OE1 1 
ATOM   4716 N  NE2 . GLN D 1 202 ? 39.918  -33.131 10.534  1.00 17.70  ? 197 GLN M NE2 1 
ATOM   4717 N  N   . GLY D 1 203 ? 40.412  -37.804 6.320   1.00 32.12  ? 198 GLY M N   1 
ATOM   4718 C  CA  . GLY D 1 203 ? 40.075  -37.982 4.921   1.00 37.24  ? 198 GLY M CA  1 
ATOM   4719 C  C   . GLY D 1 203 ? 41.203  -38.723 4.230   1.00 27.47  ? 198 GLY M C   1 
ATOM   4720 O  O   . GLY D 1 203 ? 41.532  -39.844 4.609   1.00 34.90  ? 198 GLY M O   1 
ATOM   4721 N  N   . THR D 1 204 ? 41.805  -38.096 3.223   1.00 31.52  ? 199 THR M N   1 
ATOM   4722 C  CA  . THR D 1 204 ? 42.958  -38.688 2.549   1.00 35.35  ? 199 THR M CA  1 
ATOM   4723 C  C   . THR D 1 204 ? 44.266  -37.961 2.856   1.00 36.12  ? 199 THR M C   1 
ATOM   4724 O  O   . THR D 1 204 ? 45.284  -38.197 2.200   1.00 30.58  ? 199 THR M O   1 
ATOM   4725 C  CB  . THR D 1 204 ? 42.747  -38.733 1.030   1.00 34.35  ? 199 THR M CB  1 
ATOM   4726 O  OG1 . THR D 1 204 ? 42.420  -37.421 0.555   1.00 37.44  ? 199 THR M OG1 1 
ATOM   4727 C  CG2 . THR D 1 204 ? 41.610  -39.702 0.687   1.00 33.70  ? 199 THR M CG2 1 
ATOM   4728 N  N   . THR D 1 205 ? 44.237  -37.075 3.849   1.00 32.88  ? 200 THR M N   1 
ATOM   4729 C  CA  . THR D 1 205 ? 45.422  -36.298 4.199   1.00 27.67  ? 200 THR M CA  1 
ATOM   4730 C  C   . THR D 1 205 ? 45.902  -36.638 5.592   1.00 35.07  ? 200 THR M C   1 
ATOM   4731 O  O   . THR D 1 205 ? 45.142  -36.556 6.552   1.00 33.68  ? 200 THR M O   1 
ATOM   4732 C  CB  . THR D 1 205 ? 45.150  -34.795 4.147   1.00 37.91  ? 200 THR M CB  1 
ATOM   4733 O  OG1 . THR D 1 205 ? 44.731  -34.436 2.826   1.00 37.42  ? 200 THR M OG1 1 
ATOM   4734 C  CG2 . THR D 1 205 ? 46.416  -33.996 4.534   1.00 36.66  ? 200 THR M CG2 1 
ATOM   4735 N  N   . SER D 1 206 ? 47.169  -37.013 5.701   1.00 29.75  ? 201 SER M N   1 
ATOM   4736 C  CA  . SER D 1 206 ? 47.732  -37.388 6.979   1.00 22.41  ? 201 SER M CA  1 
ATOM   4737 C  C   . SER D 1 206 ? 48.779  -36.390 7.436   1.00 32.29  ? 201 SER M C   1 
ATOM   4738 O  O   . SER D 1 206 ? 49.401  -35.710 6.617   1.00 28.32  ? 201 SER M O   1 
ATOM   4739 C  CB  . SER D 1 206 ? 48.357  -38.778 6.899   1.00 26.16  ? 201 SER M CB  1 
ATOM   4740 O  OG  . SER D 1 206 ? 47.384  -39.770 6.610   1.00 27.61  ? 201 SER M OG  1 
ATOM   4741 N  N   . VAL D 1 207 ? 48.938  -36.286 8.753   1.00 30.76  ? 202 VAL M N   1 
ATOM   4742 C  CA  . VAL D 1 207 ? 50.074  -35.590 9.356   1.00 24.72  ? 202 VAL M CA  1 
ATOM   4743 C  C   . VAL D 1 207 ? 50.853  -36.644 10.108  1.00 27.61  ? 202 VAL M C   1 
ATOM   4744 O  O   . VAL D 1 207 ? 50.266  -37.450 10.826  1.00 29.57  ? 202 VAL M O   1 
ATOM   4745 C  CB  . VAL D 1 207 ? 49.627  -34.459 10.306  1.00 30.96  ? 202 VAL M CB  1 
ATOM   4746 C  CG1 . VAL D 1 207 ? 50.824  -33.854 11.024  1.00 27.69  ? 202 VAL M CG1 1 
ATOM   4747 C  CG2 . VAL D 1 207 ? 48.886  -33.375 9.532   1.00 27.72  ? 202 VAL M CG2 1 
ATOM   4748 N  N   . VAL D 1 208 ? 52.168  -36.668 9.919   1.00 30.93  ? 203 VAL M N   1 
ATOM   4749 C  CA  . VAL D 1 208 ? 53.002  -37.733 10.470  1.00 30.21  ? 203 VAL M CA  1 
ATOM   4750 C  C   . VAL D 1 208 ? 54.095  -37.157 11.367  1.00 30.45  ? 203 VAL M C   1 
ATOM   4751 O  O   . VAL D 1 208 ? 54.805  -36.238 10.968  1.00 37.51  ? 203 VAL M O   1 
ATOM   4752 C  CB  . VAL D 1 208 ? 53.681  -38.551 9.339   1.00 37.84  ? 203 VAL M CB  1 
ATOM   4753 C  CG1 . VAL D 1 208 ? 54.571  -39.630 9.925   1.00 33.27  ? 203 VAL M CG1 1 
ATOM   4754 C  CG2 . VAL D 1 208 ? 52.643  -39.170 8.411   1.00 34.00  ? 203 VAL M CG2 1 
ATOM   4755 N  N   . GLN D 1 209 ? 54.226  -37.682 12.581  1.00 35.03  ? 204 GLN M N   1 
ATOM   4756 C  CA  . GLN D 1 209 ? 55.309  -37.269 13.468  1.00 28.19  ? 204 GLN M CA  1 
ATOM   4757 C  C   . GLN D 1 209 ? 56.083  -38.488 13.941  1.00 29.72  ? 204 GLN M C   1 
ATOM   4758 O  O   . GLN D 1 209 ? 55.482  -39.496 14.303  1.00 22.61  ? 204 GLN M O   1 
ATOM   4759 C  CB  . GLN D 1 209 ? 54.769  -36.483 14.674  1.00 27.25  ? 204 GLN M CB  1 
ATOM   4760 C  CG  . GLN D 1 209 ? 54.149  -35.120 14.338  1.00 23.12  ? 204 GLN M CG  1 
ATOM   4761 C  CD  . GLN D 1 209 ? 55.179  -34.093 13.901  1.00 35.13  ? 204 GLN M CD  1 
ATOM   4762 O  OE1 . GLN D 1 209 ? 56.385  -34.335 13.974  1.00 31.07  ? 204 GLN M OE1 1 
ATOM   4763 N  NE2 . GLN D 1 209 ? 54.708  -32.939 13.433  1.00 32.79  ? 204 GLN M NE2 1 
ATOM   4764 N  N   . SER D 1 210 ? 57.416  -38.390 13.943  1.00 32.69  ? 205 SER M N   1 
ATOM   4765 C  CA  . SER D 1 210 ? 58.271  -39.503 14.356  1.00 27.55  ? 205 SER M CA  1 
ATOM   4766 C  C   . SER D 1 210 ? 59.457  -39.049 15.198  1.00 30.75  ? 205 SER M C   1 
ATOM   4767 O  O   . SER D 1 210 ? 59.843  -37.872 15.167  1.00 27.50  ? 205 SER M O   1 
ATOM   4768 C  CB  . SER D 1 210 ? 58.804  -40.238 13.124  1.00 31.71  ? 205 SER M CB  1 
ATOM   4769 O  OG  . SER D 1 210 ? 57.752  -40.638 12.271  1.00 40.65  ? 205 SER M OG  1 
ATOM   4770 N  N   . PHE D 1 211 ? 60.032  -39.987 15.949  1.00 26.98  ? 206 PHE M N   1 
ATOM   4771 C  CA  . PHE D 1 211 ? 61.345  -39.790 16.571  1.00 27.40  ? 206 PHE M CA  1 
ATOM   4772 C  C   . PHE D 1 211 ? 62.125  -41.102 16.522  1.00 34.91  ? 206 PHE M C   1 
ATOM   4773 O  O   . PHE D 1 211 ? 61.533  -42.165 16.333  1.00 31.61  ? 206 PHE M O   1 
ATOM   4774 C  CB  . PHE D 1 211 ? 61.232  -39.295 18.022  1.00 26.94  ? 206 PHE M CB  1 
ATOM   4775 C  CG  . PHE D 1 211 ? 60.672  -40.321 18.976  1.00 32.60  ? 206 PHE M CG  1 
ATOM   4776 C  CD1 . PHE D 1 211 ? 61.510  -41.156 19.694  1.00 29.33  ? 206 PHE M CD1 1 
ATOM   4777 C  CD2 . PHE D 1 211 ? 59.299  -40.441 19.159  1.00 28.92  ? 206 PHE M CD2 1 
ATOM   4778 C  CE1 . PHE D 1 211 ? 60.995  -42.109 20.572  1.00 33.38  ? 206 PHE M CE1 1 
ATOM   4779 C  CE2 . PHE D 1 211 ? 58.773  -41.390 20.035  1.00 27.80  ? 206 PHE M CE2 1 
ATOM   4780 C  CZ  . PHE D 1 211 ? 59.622  -42.223 20.744  1.00 25.77  ? 206 PHE M CZ  1 
ATOM   4781 N  N   . ASN D 1 212 ? 63.445  -41.021 16.679  1.00 35.63  ? 207 ASN M N   1 
ATOM   4782 C  CA  . ASN D 1 212 ? 64.282  -42.210 16.855  1.00 34.95  ? 207 ASN M CA  1 
ATOM   4783 C  C   . ASN D 1 212 ? 64.651  -42.359 18.318  1.00 40.36  ? 207 ASN M C   1 
ATOM   4784 O  O   . ASN D 1 212 ? 65.035  -41.382 18.970  1.00 38.94  ? 207 ASN M O   1 
ATOM   4785 C  CB  . ASN D 1 212 ? 65.556  -42.120 16.018  1.00 44.74  ? 207 ASN M CB  1 
ATOM   4786 C  CG  . ASN D 1 212 ? 65.284  -42.162 14.535  1.00 41.60  ? 207 ASN M CG  1 
ATOM   4787 O  OD1 . ASN D 1 212 ? 64.423  -42.903 14.068  1.00 47.89  ? 207 ASN M OD1 1 
ATOM   4788 N  ND2 . ASN D 1 212 ? 66.023  -41.361 13.778  1.00 55.75  ? 207 ASN M ND2 1 
ATOM   4789 N  N   . ARG D 1 213 ? 64.532  -43.578 18.832  1.00 37.86  ? 208 ARG M N   1 
ATOM   4790 C  CA  . ARG D 1 213 ? 64.764  -43.835 20.251  1.00 36.81  ? 208 ARG M CA  1 
ATOM   4791 C  C   . ARG D 1 213 ? 66.095  -43.284 20.757  1.00 46.05  ? 208 ARG M C   1 
ATOM   4792 O  O   . ARG D 1 213 ? 66.159  -42.648 21.813  1.00 48.40  ? 208 ARG M O   1 
ATOM   4793 C  CB  . ARG D 1 213 ? 64.682  -45.331 20.539  1.00 37.26  ? 208 ARG M CB  1 
ATOM   4794 C  CG  . ARG D 1 213 ? 65.104  -45.721 21.944  1.00 37.86  ? 208 ARG M CG  1 
ATOM   4795 C  CD  . ARG D 1 213 ? 64.934  -47.227 22.131  1.00 50.06  ? 208 ARG M CD  1 
ATOM   4796 N  NE  . ARG D 1 213 ? 65.577  -47.970 21.048  1.00 49.51  ? 208 ARG M NE  1 
ATOM   4797 C  CZ  . ARG D 1 213 ? 66.868  -48.287 21.035  1.00 48.04  ? 208 ARG M CZ  1 
ATOM   4798 N  NH1 . ARG D 1 213 ? 67.643  -47.929 22.053  1.00 38.92  ? 208 ARG M NH1 1 
ATOM   4799 N  NH2 . ARG D 1 213 ? 67.385  -48.955 20.013  1.00 42.92  ? 208 ARG M NH2 1 
ATOM   4800 N  N   . GLY D 1 214 ? 67.157  -43.519 19.994  1.00 44.20  ? 209 GLY M N   1 
ATOM   4801 C  CA  . GLY D 1 214 ? 68.485  -43.104 20.404  1.00 50.01  ? 209 GLY M CA  1 
ATOM   4802 C  C   . GLY D 1 214 ? 68.797  -41.639 20.166  1.00 50.84  ? 209 GLY M C   1 
ATOM   4803 O  O   . GLY D 1 214 ? 69.924  -41.199 20.389  1.00 59.98  ? 209 GLY M O   1 
ATOM   4804 N  N   . ASP D 1 215 ? 67.805  -40.875 19.718  1.00 48.92  ? 210 ASP M N   1 
ATOM   4805 C  CA  . ASP D 1 215 ? 68.001  -39.447 19.466  1.00 44.55  ? 210 ASP M CA  1 
ATOM   4806 C  C   . ASP D 1 215 ? 67.510  -38.551 20.609  1.00 46.70  ? 210 ASP M C   1 
ATOM   4807 O  O   . ASP D 1 215 ? 67.768  -37.349 20.607  1.00 53.29  ? 210 ASP M O   1 
ATOM   4808 C  CB  . ASP D 1 215 ? 67.319  -39.034 18.154  1.00 52.46  ? 210 ASP M CB  1 
ATOM   4809 C  CG  . ASP D 1 215 ? 68.055  -39.538 16.923  1.00 62.98  ? 210 ASP M CG  1 
ATOM   4810 O  OD1 . ASP D 1 215 ? 69.076  -40.247 17.073  1.00 59.96  ? 210 ASP M OD1 1 
ATOM   4811 O  OD2 . ASP D 1 215 ? 67.600  -39.230 15.800  1.00 57.43  ? 210 ASP M OD2 1 
ATOM   4812 N  N   . CYS D 1 216 ? 66.804  -39.126 21.582  1.00 50.84  ? 211 CYS M N   1 
ATOM   4813 C  CA  . CYS D 1 216 ? 66.166  -38.323 22.632  1.00 52.80  ? 211 CYS M CA  1 
ATOM   4814 C  C   . CYS D 1 216 ? 66.938  -38.313 23.946  1.00 48.89  ? 211 CYS M C   1 
ATOM   4815 O  O   . CYS D 1 216 ? 67.949  -38.997 24.089  1.00 56.32  ? 211 CYS M O   1 
ATOM   4816 C  CB  . CYS D 1 216 ? 64.733  -38.796 22.888  1.00 49.57  ? 211 CYS M CB  1 
ATOM   4817 S  SG  . CYS D 1 216 ? 63.676  -38.826 21.445  1.00 50.26  ? 211 CYS M SG  1 
ATOM   4818 N  N   . GLN E 2 1   ? 23.677  -17.561 45.897  1.00 47.10  ? 2   GLN I N   1 
ATOM   4819 C  CA  . GLN E 2 1   ? 23.045  -18.785 46.363  1.00 33.13  ? 2   GLN I CA  1 
ATOM   4820 C  C   . GLN E 2 1   ? 23.614  -19.975 45.598  1.00 32.68  ? 2   GLN I C   1 
ATOM   4821 O  O   . GLN E 2 1   ? 23.682  -19.952 44.370  1.00 26.51  ? 2   GLN I O   1 
ATOM   4822 C  CB  . GLN E 2 1   ? 21.518  -18.695 46.224  1.00 40.60  ? 2   GLN I CB  1 
ATOM   4823 C  CG  . GLN E 2 1   ? 20.990  -18.348 44.828  1.00 50.96  ? 2   GLN I CG  1 
ATOM   4824 C  CD  . GLN E 2 1   ? 21.322  -16.932 44.375  1.00 57.05  ? 2   GLN I CD  1 
ATOM   4825 O  OE1 . GLN E 2 1   ? 22.129  -16.240 44.993  1.00 44.36  ? 2   GLN I OE1 1 
ATOM   4826 N  NE2 . GLN E 2 1   ? 20.702  -16.500 43.277  1.00 64.51  ? 2   GLN I NE2 1 
ATOM   4827 N  N   . SER E 2 2   ? 24.034  -21.003 46.331  1.00 28.14  ? 3   SER I N   1 
ATOM   4828 C  CA  . SER E 2 2   ? 24.705  -22.152 45.732  1.00 29.18  ? 3   SER I CA  1 
ATOM   4829 C  C   . SER E 2 2   ? 24.638  -23.396 46.629  1.00 25.04  ? 3   SER I C   1 
ATOM   4830 O  O   . SER E 2 2   ? 24.314  -23.313 47.819  1.00 27.17  ? 3   SER I O   1 
ATOM   4831 C  CB  . SER E 2 2   ? 26.166  -21.809 45.447  1.00 29.08  ? 3   SER I CB  1 
ATOM   4832 O  OG  . SER E 2 2   ? 26.878  -21.601 46.661  1.00 30.54  ? 3   SER I OG  1 
ATOM   4833 N  N   . LEU E 2 3   ? 24.957  -24.542 46.046  1.00 27.23  ? 4   LEU I N   1 
ATOM   4834 C  CA  . LEU E 2 3   ? 24.938  -25.801 46.773  1.00 26.69  ? 4   LEU I CA  1 
ATOM   4835 C  C   . LEU E 2 3   ? 26.281  -26.488 46.647  1.00 22.50  ? 4   LEU I C   1 
ATOM   4836 O  O   . LEU E 2 3   ? 26.947  -26.368 45.625  1.00 24.66  ? 4   LEU I O   1 
ATOM   4837 C  CB  . LEU E 2 3   ? 23.847  -26.716 46.219  1.00 20.84  ? 4   LEU I CB  1 
ATOM   4838 C  CG  . LEU E 2 3   ? 22.416  -26.217 46.421  1.00 22.79  ? 4   LEU I CG  1 
ATOM   4839 C  CD1 . LEU E 2 3   ? 21.453  -27.011 45.554  1.00 19.75  ? 4   LEU I CD1 1 
ATOM   4840 C  CD2 . LEU E 2 3   ? 22.016  -26.307 47.880  1.00 20.05  ? 4   LEU I CD2 1 
ATOM   4841 N  N   . GLU E 2 4   ? 26.684  -27.204 47.689  1.00 21.48  ? 5   GLU I N   1 
ATOM   4842 C  CA  . GLU E 2 4   ? 27.868  -28.050 47.590  1.00 21.52  ? 5   GLU I CA  1 
ATOM   4843 C  C   . GLU E 2 4   ? 27.664  -29.376 48.307  1.00 23.65  ? 5   GLU I C   1 
ATOM   4844 O  O   . GLU E 2 4   ? 27.230  -29.404 49.471  1.00 22.72  ? 5   GLU I O   1 
ATOM   4845 C  CB  . GLU E 2 4   ? 29.117  -27.347 48.133  1.00 25.81  ? 5   GLU I CB  1 
ATOM   4846 C  CG  . GLU E 2 4   ? 30.384  -28.178 47.914  1.00 31.79  ? 5   GLU I CG  1 
ATOM   4847 C  CD  . GLU E 2 4   ? 31.652  -27.504 48.420  1.00 47.52  ? 5   GLU I CD  1 
ATOM   4848 O  OE1 . GLU E 2 4   ? 31.558  -26.466 49.114  1.00 46.48  ? 5   GLU I OE1 1 
ATOM   4849 O  OE2 . GLU E 2 4   ? 32.747  -28.025 48.121  1.00 50.56  ? 5   GLU I OE2 1 
ATOM   4850 N  N   . GLU E 2 5   ? 27.975  -30.467 47.604  1.00 23.71  ? 6   GLU I N   1 
ATOM   4851 C  CA  . GLU E 2 5   ? 27.880  -31.815 48.162  1.00 19.72  ? 6   GLU I CA  1 
ATOM   4852 C  C   . GLU E 2 5   ? 29.244  -32.248 48.680  1.00 25.86  ? 6   GLU I C   1 
ATOM   4853 O  O   . GLU E 2 5   ? 30.277  -31.897 48.101  1.00 23.93  ? 6   GLU I O   1 
ATOM   4854 C  CB  . GLU E 2 5   ? 27.417  -32.837 47.106  1.00 20.80  ? 6   GLU I CB  1 
ATOM   4855 C  CG  . GLU E 2 5   ? 26.118  -32.490 46.356  1.00 19.41  ? 6   GLU I CG  1 
ATOM   4856 C  CD  . GLU E 2 5   ? 26.380  -31.698 45.072  1.00 21.72  ? 6   GLU I CD  1 
ATOM   4857 O  OE1 . GLU E 2 5   ? 25.462  -31.553 44.247  1.00 19.39  ? 6   GLU I OE1 1 
ATOM   4858 O  OE2 . GLU E 2 5   ? 27.512  -31.209 44.888  1.00 22.98  ? 6   GLU I OE2 1 
ATOM   4859 N  N   . SER E 2 6   ? 29.256  -33.045 49.742  1.00 21.63  ? 7   SER I N   1 
ATOM   4860 C  CA  . SER E 2 6   ? 30.515  -33.588 50.258  1.00 25.81  ? 7   SER I CA  1 
ATOM   4861 C  C   . SER E 2 6   ? 30.306  -34.956 50.890  1.00 29.97  ? 7   SER I C   1 
ATOM   4862 O  O   . SER E 2 6   ? 29.174  -35.354 51.150  1.00 24.32  ? 7   SER I O   1 
ATOM   4863 C  CB  . SER E 2 6   ? 31.119  -32.637 51.290  1.00 22.56  ? 7   SER I CB  1 
ATOM   4864 O  OG  . SER E 2 6   ? 30.272  -32.548 52.421  1.00 25.19  ? 7   SER I OG  1 
ATOM   4865 N  N   . GLY E 2 7   ? 31.404  -35.669 51.135  1.00 25.21  ? 8   GLY I N   1 
ATOM   4866 C  CA  . GLY E 2 7   ? 31.349  -36.992 51.748  1.00 23.84  ? 8   GLY I CA  1 
ATOM   4867 C  C   . GLY E 2 7   ? 31.592  -38.147 50.792  1.00 22.52  ? 8   GLY I C   1 
ATOM   4868 O  O   . GLY E 2 7   ? 31.645  -39.302 51.213  1.00 28.20  ? 8   GLY I O   1 
ATOM   4869 N  N   . GLY E 2 8   ? 31.721  -37.855 49.500  1.00 27.49  ? 9   GLY I N   1 
ATOM   4870 C  CA  . GLY E 2 8   ? 32.073  -38.885 48.534  1.00 24.19  ? 9   GLY I CA  1 
ATOM   4871 C  C   . GLY E 2 8   ? 33.365  -39.583 48.942  1.00 31.90  ? 9   GLY I C   1 
ATOM   4872 O  O   . GLY E 2 8   ? 34.261  -38.947 49.477  1.00 26.99  ? 9   GLY I O   1 
ATOM   4873 N  N   . ASP E 2 9   ? 33.466  -40.883 48.693  1.00 28.92  ? 10  ASP I N   1 
ATOM   4874 C  CA  . ASP E 2 9   ? 34.632  -41.638 49.131  1.00 29.95  ? 10  ASP I CA  1 
ATOM   4875 C  C   . ASP E 2 9   ? 34.652  -43.011 48.473  1.00 32.61  ? 10  ASP I C   1 
ATOM   4876 O  O   . ASP E 2 9   ? 33.673  -43.434 47.855  1.00 26.84  ? 10  ASP I O   1 
ATOM   4877 C  CB  . ASP E 2 9   ? 34.615  -41.791 50.659  1.00 32.59  ? 10  ASP I CB  1 
ATOM   4878 C  CG  . ASP E 2 9   ? 35.997  -42.110 51.243  1.00 40.83  ? 10  ASP I CG  1 
ATOM   4879 O  OD1 . ASP E 2 9   ? 36.090  -42.266 52.476  1.00 47.66  ? 10  ASP I OD1 1 
ATOM   4880 O  OD2 . ASP E 2 9   ? 36.978  -42.217 50.478  1.00 35.97  ? 10  ASP I OD2 1 
ATOM   4881 N  N   . LEU E 2 10  ? 35.778  -43.703 48.596  1.00 29.85  ? 11  LEU I N   1 
ATOM   4882 C  CA  . LEU E 2 10  ? 35.872  -45.097 48.180  1.00 28.00  ? 11  LEU I CA  1 
ATOM   4883 C  C   . LEU E 2 10  ? 35.430  -45.952 49.375  1.00 29.90  ? 11  LEU I C   1 
ATOM   4884 O  O   . LEU E 2 10  ? 35.918  -45.746 50.488  1.00 33.29  ? 11  LEU I O   1 
ATOM   4885 C  CB  . LEU E 2 10  ? 37.318  -45.425 47.803  1.00 31.50  ? 11  LEU I CB  1 
ATOM   4886 C  CG  . LEU E 2 10  ? 37.706  -46.902 47.667  1.00 26.76  ? 11  LEU I CG  1 
ATOM   4887 C  CD1 . LEU E 2 10  ? 37.179  -47.473 46.375  1.00 27.90  ? 11  LEU I CD1 1 
ATOM   4888 C  CD2 . LEU E 2 10  ? 39.212  -47.085 47.737  1.00 36.05  ? 11  LEU I CD2 1 
ATOM   4889 N  N   . VAL E 2 11  ? 34.505  -46.890 49.166  1.00 28.70  ? 12  VAL I N   1 
ATOM   4890 C  CA  . VAL E 2 11  ? 34.044  -47.746 50.265  1.00 24.80  ? 12  VAL I CA  1 
ATOM   4891 C  C   . VAL E 2 11  ? 33.914  -49.191 49.814  1.00 28.84  ? 12  VAL I C   1 
ATOM   4892 O  O   . VAL E 2 11  ? 33.812  -49.468 48.622  1.00 29.66  ? 12  VAL I O   1 
ATOM   4893 C  CB  . VAL E 2 11  ? 32.690  -47.270 50.872  1.00 30.45  ? 12  VAL I CB  1 
ATOM   4894 C  CG1 . VAL E 2 11  ? 32.806  -45.867 51.432  1.00 29.34  ? 12  VAL I CG1 1 
ATOM   4895 C  CG2 . VAL E 2 11  ? 31.570  -47.348 49.834  1.00 25.52  ? 12  VAL I CG2 1 
ATOM   4896 N  N   . GLN E 2 12  ? 33.921  -50.116 50.772  1.00 30.92  ? 13  GLN I N   1 
ATOM   4897 C  CA  . GLN E 2 12  ? 33.815  -51.535 50.454  1.00 27.50  ? 13  GLN I CA  1 
ATOM   4898 C  C   . GLN E 2 12  ? 32.348  -51.928 50.226  1.00 26.40  ? 13  GLN I C   1 
ATOM   4899 O  O   . GLN E 2 12  ? 31.435  -51.288 50.757  1.00 24.63  ? 13  GLN I O   1 
ATOM   4900 C  CB  . GLN E 2 12  ? 34.430  -52.378 51.584  1.00 42.44  ? 13  GLN I CB  1 
ATOM   4901 C  CG  . GLN E 2 12  ? 35.780  -51.858 52.112  1.00 47.58  ? 13  GLN I CG  1 
ATOM   4902 C  CD  . GLN E 2 12  ? 36.977  -52.658 51.610  1.00 61.26  ? 13  GLN I CD  1 
ATOM   4903 O  OE1 . GLN E 2 12  ? 36.853  -53.497 50.713  1.00 59.44  ? 13  GLN I OE1 1 
ATOM   4904 N  NE2 . GLN E 2 12  ? 38.145  -52.405 52.197  1.00 64.48  ? 13  GLN I NE2 1 
ATOM   4905 N  N   . PRO E 2 13  ? 32.115  -52.961 49.409  1.00 28.09  ? 14  PRO I N   1 
ATOM   4906 C  CA  . PRO E 2 13  ? 30.759  -53.501 49.251  1.00 28.79  ? 14  PRO I CA  1 
ATOM   4907 C  C   . PRO E 2 13  ? 30.167  -53.829 50.626  1.00 35.39  ? 14  PRO I C   1 
ATOM   4908 O  O   . PRO E 2 13  ? 30.901  -54.307 51.496  1.00 27.33  ? 14  PRO I O   1 
ATOM   4909 C  CB  . PRO E 2 13  ? 30.993  -54.789 48.470  1.00 28.83  ? 14  PRO I CB  1 
ATOM   4910 C  CG  . PRO E 2 13  ? 32.237  -54.533 47.684  1.00 34.24  ? 14  PRO I CG  1 
ATOM   4911 C  CD  . PRO E 2 13  ? 33.098  -53.663 48.562  1.00 30.81  ? 14  PRO I CD  1 
ATOM   4912 N  N   . GLY E 2 14  ? 28.883  -53.543 50.828  1.00 30.87  ? 15  GLY I N   1 
ATOM   4913 C  CA  . GLY E 2 14  ? 28.235  -53.763 52.110  1.00 24.26  ? 15  GLY I CA  1 
ATOM   4914 C  C   . GLY E 2 14  ? 28.228  -52.545 53.019  1.00 26.72  ? 15  GLY I C   1 
ATOM   4915 O  O   . GLY E 2 14  ? 27.474  -52.488 53.993  1.00 26.96  ? 15  GLY I O   1 
ATOM   4916 N  N   . ALA E 2 15  ? 29.047  -51.550 52.703  1.00 21.90  ? 16  ALA I N   1 
ATOM   4917 C  CA  . ALA E 2 15  ? 29.211  -50.404 53.597  1.00 24.90  ? 16  ALA I CA  1 
ATOM   4918 C  C   . ALA E 2 15  ? 28.026  -49.435 53.633  1.00 26.78  ? 16  ALA I C   1 
ATOM   4919 O  O   . ALA E 2 15  ? 27.122  -49.488 52.794  1.00 19.78  ? 16  ALA I O   1 
ATOM   4920 C  CB  . ALA E 2 15  ? 30.499  -49.637 53.250  1.00 29.91  ? 16  ALA I CB  1 
ATOM   4921 N  N   . SER E 2 16  ? 28.054  -48.546 54.624  1.00 24.49  ? 17  SER I N   1 
ATOM   4922 C  CA  . SER E 2 16  ? 27.142  -47.421 54.721  1.00 26.40  ? 17  SER I CA  1 
ATOM   4923 C  C   . SER E 2 16  ? 27.923  -46.115 54.534  1.00 26.28  ? 17  SER I C   1 
ATOM   4924 O  O   . SER E 2 16  ? 29.128  -46.056 54.781  1.00 28.54  ? 17  SER I O   1 
ATOM   4925 C  CB  . SER E 2 16  ? 26.425  -47.415 56.078  1.00 26.78  ? 17  SER I CB  1 
ATOM   4926 O  OG  . SER E 2 16  ? 25.594  -48.555 56.220  1.00 31.82  ? 17  SER I OG  1 
ATOM   4927 N  N   . LEU E 2 17  ? 27.231  -45.072 54.099  1.00 22.73  ? 18  LEU I N   1 
ATOM   4928 C  CA  . LEU E 2 17  ? 27.868  -43.778 53.827  1.00 20.74  ? 18  LEU I CA  1 
ATOM   4929 C  C   . LEU E 2 17  ? 26.835  -42.650 53.828  1.00 22.08  ? 18  LEU I C   1 
ATOM   4930 O  O   . LEU E 2 17  ? 25.739  -42.803 53.290  1.00 21.73  ? 18  LEU I O   1 
ATOM   4931 C  CB  . LEU E 2 17  ? 28.613  -43.831 52.480  1.00 21.99  ? 18  LEU I CB  1 
ATOM   4932 C  CG  . LEU E 2 17  ? 29.386  -42.572 52.050  1.00 19.71  ? 18  LEU I CG  1 
ATOM   4933 C  CD1 . LEU E 2 17  ? 30.532  -42.280 53.012  1.00 26.03  ? 18  LEU I CD1 1 
ATOM   4934 C  CD2 . LEU E 2 17  ? 29.922  -42.743 50.625  1.00 20.11  ? 18  LEU I CD2 1 
ATOM   4935 N  N   . THR E 2 18  ? 27.180  -41.520 54.439  1.00 19.04  ? 19  THR I N   1 
ATOM   4936 C  CA  . THR E 2 18  ? 26.291  -40.368 54.484  1.00 20.67  ? 19  THR I CA  1 
ATOM   4937 C  C   . THR E 2 18  ? 26.873  -39.165 53.710  1.00 26.04  ? 19  THR I C   1 
ATOM   4938 O  O   . THR E 2 18  ? 27.991  -38.723 53.980  1.00 23.76  ? 19  THR I O   1 
ATOM   4939 C  CB  . THR E 2 18  ? 26.004  -39.966 55.940  1.00 26.65  ? 19  THR I CB  1 
ATOM   4940 O  OG1 . THR E 2 18  ? 25.287  -41.026 56.585  1.00 23.00  ? 19  THR I OG1 1 
ATOM   4941 C  CG2 . THR E 2 18  ? 25.178  -38.692 56.005  1.00 21.36  ? 19  THR I CG2 1 
ATOM   4942 N  N   . LEU E 2 19  ? 26.128  -38.659 52.729  1.00 17.80  ? 20  LEU I N   1 
ATOM   4943 C  CA  . LEU E 2 19  ? 26.550  -37.483 51.973  1.00 18.55  ? 20  LEU I CA  1 
ATOM   4944 C  C   . LEU E 2 19  ? 25.838  -36.262 52.531  1.00 21.37  ? 20  LEU I C   1 
ATOM   4945 O  O   . LEU E 2 19  ? 24.724  -36.362 53.066  1.00 21.45  ? 20  LEU I O   1 
ATOM   4946 C  CB  . LEU E 2 19  ? 26.247  -37.642 50.476  1.00 20.18  ? 20  LEU I CB  1 
ATOM   4947 C  CG  . LEU E 2 19  ? 26.754  -38.905 49.786  1.00 22.94  ? 20  LEU I CG  1 
ATOM   4948 C  CD1 . LEU E 2 19  ? 26.343  -38.900 48.302  1.00 18.08  ? 20  LEU I CD1 1 
ATOM   4949 C  CD2 . LEU E 2 19  ? 28.278  -39.006 49.937  1.00 21.00  ? 20  LEU I CD2 1 
ATOM   4950 N  N   . THR E 2 20  ? 26.467  -35.103 52.403  1.00 20.36  ? 21  THR I N   1 
ATOM   4951 C  CA  . THR E 2 20  ? 25.863  -33.855 52.879  1.00 21.95  ? 21  THR I CA  1 
ATOM   4952 C  C   . THR E 2 20  ? 25.741  -32.837 51.759  1.00 25.98  ? 21  THR I C   1 
ATOM   4953 O  O   . THR E 2 20  ? 26.667  -32.692 50.958  1.00 24.32  ? 21  THR I O   1 
ATOM   4954 C  CB  . THR E 2 20  ? 26.704  -33.236 54.008  1.00 22.33  ? 21  THR I CB  1 
ATOM   4955 O  OG1 . THR E 2 20  ? 26.779  -34.157 55.098  1.00 25.00  ? 21  THR I OG1 1 
ATOM   4956 C  CG2 . THR E 2 20  ? 26.087  -31.926 54.500  1.00 25.31  ? 21  THR I CG2 1 
ATOM   4957 N  N   . CYS E 2 21  ? 24.593  -32.160 51.699  1.00 16.58  ? 22  CYS I N   1 
ATOM   4958 C  CA  . CYS E 2 21  ? 24.357  -31.059 50.769  1.00 24.17  ? 22  CYS I CA  1 
ATOM   4959 C  C   . CYS E 2 21  ? 24.286  -29.755 51.568  1.00 23.07  ? 22  CYS I C   1 
ATOM   4960 O  O   . CYS E 2 21  ? 23.361  -29.562 52.368  1.00 23.95  ? 22  CYS I O   1 
ATOM   4961 C  CB  . CYS E 2 21  ? 23.039  -31.280 50.008  1.00 22.42  ? 22  CYS I CB  1 
ATOM   4962 S  SG  . CYS E 2 21  ? 22.536  -29.926 48.921  1.00 30.86  ? 22  CYS I SG  1 
ATOM   4963 N  N   . LYS E 2 22  ? 25.252  -28.865 51.346  1.00 19.39  ? 23  LYS I N   1 
ATOM   4964 C  CA  . LYS E 2 22  ? 25.344  -27.608 52.104  1.00 24.18  ? 23  LYS I CA  1 
ATOM   4965 C  C   . LYS E 2 22  ? 24.859  -26.402 51.314  1.00 22.78  ? 23  LYS I C   1 
ATOM   4966 O  O   . LYS E 2 22  ? 25.334  -26.143 50.197  1.00 21.51  ? 23  LYS I O   1 
ATOM   4967 C  CB  . LYS E 2 22  ? 26.789  -27.367 52.550  1.00 24.88  ? 23  LYS I CB  1 
ATOM   4968 C  CG  . LYS E 2 22  ? 27.034  -25.994 53.190  1.00 27.12  ? 23  LYS I CG  1 
ATOM   4969 C  CD  . LYS E 2 22  ? 26.448  -25.913 54.606  1.00 26.08  ? 23  LYS I CD  1 
ATOM   4970 C  CE  . LYS E 2 22  ? 26.955  -24.709 55.367  1.00 30.14  ? 23  LYS I CE  1 
ATOM   4971 N  NZ  . LYS E 2 22  ? 26.511  -24.752 56.796  1.00 36.03  ? 23  LYS I NZ  1 
ATOM   4972 N  N   . ALA E 2 23  ? 23.923  -25.656 51.895  1.00 21.55  ? 24  ALA I N   1 
ATOM   4973 C  CA  . ALA E 2 23  ? 23.389  -24.468 51.247  1.00 26.88  ? 24  ALA I CA  1 
ATOM   4974 C  C   . ALA E 2 23  ? 24.181  -23.222 51.645  1.00 30.26  ? 24  ALA I C   1 
ATOM   4975 O  O   . ALA E 2 23  ? 24.566  -23.070 52.800  1.00 26.83  ? 24  ALA I O   1 
ATOM   4976 C  CB  . ALA E 2 23  ? 21.908  -24.291 51.586  1.00 20.59  ? 24  ALA I CB  1 
ATOM   4977 N  N   . SER E 2 24  ? 24.422  -22.342 50.679  1.00 28.46  ? 25  SER I N   1 
ATOM   4978 C  CA  . SER E 2 24  ? 25.088  -21.066 50.932  1.00 30.21  ? 25  SER I CA  1 
ATOM   4979 C  C   . SER E 2 24  ? 24.250  -19.948 50.347  1.00 34.93  ? 25  SER I C   1 
ATOM   4980 O  O   . SER E 2 24  ? 23.746  -20.057 49.230  1.00 32.45  ? 25  SER I O   1 
ATOM   4981 C  CB  . SER E 2 24  ? 26.491  -21.025 50.314  1.00 29.36  ? 25  SER I CB  1 
ATOM   4982 O  OG  . SER E 2 24  ? 27.378  -21.904 50.985  1.00 34.69  ? 25  SER I OG  1 
ATOM   4983 N  N   . GLY E 2 25  ? 24.096  -18.868 51.102  1.00 36.79  ? 26  GLY I N   1 
ATOM   4984 C  CA  . GLY E 2 25  ? 23.374  -17.715 50.610  1.00 33.21  ? 26  GLY I CA  1 
ATOM   4985 C  C   . GLY E 2 25  ? 21.877  -17.854 50.667  1.00 36.56  ? 26  GLY I C   1 
ATOM   4986 O  O   . GLY E 2 25  ? 21.145  -17.003 50.161  1.00 39.42  ? 26  GLY I O   1 
ATOM   4987 N  N   . PHE E 2 26  ? 21.421  -18.937 51.286  1.00 36.41  ? 27  PHE I N   1 
ATOM   4988 C  CA  . PHE E 2 26  ? 20.005  -19.101 51.626  1.00 30.53  ? 27  PHE I CA  1 
ATOM   4989 C  C   . PHE E 2 26  ? 19.863  -20.209 52.675  1.00 25.46  ? 27  PHE I C   1 
ATOM   4990 O  O   . PHE E 2 26  ? 20.860  -20.787 53.103  1.00 36.05  ? 27  PHE I O   1 
ATOM   4991 C  CB  . PHE E 2 26  ? 19.159  -19.397 50.389  1.00 30.70  ? 27  PHE I CB  1 
ATOM   4992 C  CG  . PHE E 2 26  ? 19.361  -20.775 49.833  1.00 34.81  ? 27  PHE I CG  1 
ATOM   4993 C  CD1 . PHE E 2 26  ? 18.405  -21.751 50.021  1.00 29.66  ? 27  PHE I CD1 1 
ATOM   4994 C  CD2 . PHE E 2 26  ? 20.516  -21.100 49.141  1.00 33.70  ? 27  PHE I CD2 1 
ATOM   4995 C  CE1 . PHE E 2 26  ? 18.585  -23.034 49.533  1.00 33.96  ? 27  PHE I CE1 1 
ATOM   4996 C  CE2 . PHE E 2 26  ? 20.706  -22.374 48.642  1.00 33.15  ? 27  PHE I CE2 1 
ATOM   4997 C  CZ  . PHE E 2 26  ? 19.739  -23.352 48.838  1.00 29.64  ? 27  PHE I CZ  1 
ATOM   4998 N  N   . SER E 2 27  ? 18.636  -20.489 53.102  1.00 34.31  ? 28  SER I N   1 
ATOM   4999 C  CA  . SER E 2 27  ? 18.419  -21.453 54.183  1.00 33.80  ? 28  SER I CA  1 
ATOM   5000 C  C   . SER E 2 27  ? 17.160  -22.301 53.981  1.00 34.97  ? 28  SER I C   1 
ATOM   5001 O  O   . SER E 2 27  ? 16.222  -21.899 53.293  1.00 33.46  ? 28  SER I O   1 
ATOM   5002 C  CB  . SER E 2 27  ? 18.331  -20.748 55.546  1.00 41.84  ? 28  SER I CB  1 
ATOM   5003 O  OG  . SER E 2 27  ? 16.972  -20.472 55.879  1.00 32.14  ? 28  SER I OG  1 
ATOM   5004 N  N   . PHE E 2 28  ? 17.139  -23.476 54.611  1.00 32.02  ? 29  PHE I N   1 
ATOM   5005 C  CA  . PHE E 2 28  ? 16.045  -24.428 54.435  1.00 28.22  ? 29  PHE I CA  1 
ATOM   5006 C  C   . PHE E 2 28  ? 14.814  -24.123 55.288  1.00 34.61  ? 29  PHE I C   1 
ATOM   5007 O  O   . PHE E 2 28  ? 13.897  -24.930 55.365  1.00 37.70  ? 29  PHE I O   1 
ATOM   5008 C  CB  . PHE E 2 28  ? 16.533  -25.858 54.698  1.00 30.77  ? 29  PHE I CB  1 
ATOM   5009 C  CG  . PHE E 2 28  ? 17.568  -26.321 53.722  1.00 29.27  ? 29  PHE I CG  1 
ATOM   5010 C  CD1 . PHE E 2 28  ? 18.712  -26.973 54.160  1.00 26.47  ? 29  PHE I CD1 1 
ATOM   5011 C  CD2 . PHE E 2 28  ? 17.412  -26.079 52.364  1.00 27.98  ? 29  PHE I CD2 1 
ATOM   5012 C  CE1 . PHE E 2 28  ? 19.691  -27.390 53.254  1.00 27.20  ? 29  PHE I CE1 1 
ATOM   5013 C  CE2 . PHE E 2 28  ? 18.382  -26.489 51.454  1.00 23.53  ? 29  PHE I CE2 1 
ATOM   5014 C  CZ  . PHE E 2 28  ? 19.520  -27.148 51.897  1.00 30.89  ? 29  PHE I CZ  1 
ATOM   5015 N  N   . GLY E 2 29  ? 14.793  -22.961 55.929  1.00 32.67  ? 30  GLY I N   1 
ATOM   5016 C  CA  . GLY E 2 29  ? 13.593  -22.494 56.592  1.00 32.97  ? 30  GLY I CA  1 
ATOM   5017 C  C   . GLY E 2 29  ? 12.512  -22.041 55.617  1.00 33.83  ? 30  GLY I C   1 
ATOM   5018 O  O   . GLY E 2 29  ? 11.356  -21.890 56.004  1.00 36.80  ? 30  GLY I O   1 
ATOM   5019 N  N   . ASN E 2 30  ? 12.886  -21.793 54.365  1.00 32.14  ? 31  ASN I N   1 
ATOM   5020 C  CA  . ASN E 2 30  ? 11.906  -21.501 53.313  1.00 34.56  ? 31  ASN I CA  1 
ATOM   5021 C  C   . ASN E 2 30  ? 11.493  -22.798 52.610  1.00 34.91  ? 31  ASN I C   1 
ATOM   5022 O  O   . ASN E 2 30  ? 12.073  -23.850 52.869  1.00 31.80  ? 31  ASN I O   1 
ATOM   5023 C  CB  . ASN E 2 30  ? 12.479  -20.513 52.293  1.00 34.53  ? 31  ASN I CB  1 
ATOM   5024 C  CG  . ASN E 2 30  ? 12.731  -19.150 52.886  1.00 46.43  ? 31  ASN I CG  1 
ATOM   5025 O  OD1 . ASN E 2 30  ? 11.797  -18.381 53.086  1.00 42.48  ? 31  ASN I OD1 1 
ATOM   5026 N  ND2 . ASN E 2 30  ? 13.996  -18.843 53.176  1.00 44.25  ? 31  ASN I ND2 1 
ATOM   5027 N  N   . ASN E 2 31  ? 10.507  -22.716 51.724  1.00 29.44  ? 32  ASN I N   1 
ATOM   5028 C  CA  . ASN E 2 31  ? 9.933   -23.899 51.074  1.00 31.00  ? 32  ASN I CA  1 
ATOM   5029 C  C   . ASN E 2 31  ? 10.614  -24.288 49.759  1.00 34.13  ? 32  ASN I C   1 
ATOM   5030 O  O   . ASN E 2 31  ? 10.494  -23.575 48.757  1.00 33.38  ? 32  ASN I O   1 
ATOM   5031 C  CB  . ASN E 2 31  ? 8.449   -23.654 50.796  1.00 38.42  ? 32  ASN I CB  1 
ATOM   5032 C  CG  . ASN E 2 31  ? 7.753   -22.961 51.945  1.00 52.92  ? 32  ASN I CG  1 
ATOM   5033 O  OD1 . ASN E 2 31  ? 8.030   -23.243 53.116  1.00 44.08  ? 32  ASN I OD1 1 
ATOM   5034 N  ND2 . ASN E 2 31  ? 6.849   -22.035 51.621  1.00 57.75  ? 32  ASN I ND2 1 
ATOM   5035 N  N   . TYR E 2 32  ? 11.306  -25.424 49.757  1.00 21.86  ? 33  TYR I N   1 
ATOM   5036 C  CA  . TYR E 2 32  ? 11.965  -25.925 48.544  1.00 21.57  ? 33  TYR I CA  1 
ATOM   5037 C  C   . TYR E 2 32  ? 11.816  -27.427 48.478  1.00 20.81  ? 33  TYR I C   1 
ATOM   5038 O  O   . TYR E 2 32  ? 11.579  -28.053 49.504  1.00 22.54  ? 33  TYR I O   1 
ATOM   5039 C  CB  . TYR E 2 32  ? 13.466  -25.614 48.574  1.00 19.66  ? 33  TYR I CB  1 
ATOM   5040 C  CG  . TYR E 2 32  ? 13.799  -24.166 48.750  1.00 26.62  ? 33  TYR I CG  1 
ATOM   5041 C  CD1 . TYR E 2 32  ? 13.527  -23.246 47.743  1.00 28.51  ? 33  TYR I CD1 1 
ATOM   5042 C  CD2 . TYR E 2 32  ? 14.401  -23.709 49.922  1.00 26.74  ? 33  TYR I CD2 1 
ATOM   5043 C  CE1 . TYR E 2 32  ? 13.833  -21.898 47.899  1.00 31.49  ? 33  TYR I CE1 1 
ATOM   5044 C  CE2 . TYR E 2 32  ? 14.707  -22.368 50.088  1.00 30.62  ? 33  TYR I CE2 1 
ATOM   5045 C  CZ  . TYR E 2 32  ? 14.423  -21.467 49.073  1.00 37.92  ? 33  TYR I CZ  1 
ATOM   5046 O  OH  . TYR E 2 32  ? 14.727  -20.128 49.223  1.00 39.01  ? 33  TYR I OH  1 
ATOM   5047 N  N   . ASP E 2 33  ? 11.976  -28.000 47.280  1.00 16.40  ? 34  ASP I N   1 
ATOM   5048 C  CA  . ASP E 2 33  ? 12.057  -29.455 47.117  1.00 17.75  ? 34  ASP I CA  1 
ATOM   5049 C  C   . ASP E 2 33  ? 13.535  -29.782 46.925  1.00 16.97  ? 34  ASP I C   1 
ATOM   5050 O  O   . ASP E 2 33  ? 14.093  -29.514 45.861  1.00 16.13  ? 34  ASP I O   1 
ATOM   5051 C  CB  . ASP E 2 33  ? 11.251  -29.904 45.888  1.00 22.11  ? 34  ASP I CB  1 
ATOM   5052 C  CG  . ASP E 2 33  ? 10.591  -31.267 46.076  1.00 25.86  ? 34  ASP I CG  1 
ATOM   5053 O  OD1 . ASP E 2 33  ? 9.696   -31.621 45.269  1.00 23.25  ? 34  ASP I OD1 1 
ATOM   5054 O  OD2 . ASP E 2 33  ? 10.962  -31.985 47.036  1.00 28.18  ? 34  ASP I OD2 1 
ATOM   5055 N  N   . MET E 2 34  ? 14.184  -30.292 47.974  1.00 18.65  ? 35  MET I N   1 
ATOM   5056 C  CA  . MET E 2 34  ? 15.601  -30.622 47.907  1.00 12.06  ? 35  MET I CA  1 
ATOM   5057 C  C   . MET E 2 34  ? 15.749  -32.100 47.530  1.00 17.30  ? 35  MET I C   1 
ATOM   5058 O  O   . MET E 2 34  ? 15.330  -32.987 48.276  1.00 17.91  ? 35  MET I O   1 
ATOM   5059 C  CB  . MET E 2 34  ? 16.291  -30.347 49.246  1.00 14.06  ? 35  MET I CB  1 
ATOM   5060 C  CG  . MET E 2 34  ? 16.226  -28.902 49.705  1.00 18.76  ? 35  MET I CG  1 
ATOM   5061 S  SD  . MET E 2 34  ? 16.935  -27.800 48.465  1.00 20.34  ? 35  MET I SD  1 
ATOM   5062 C  CE  . MET E 2 34  ? 18.619  -28.418 48.370  1.00 18.40  ? 35  MET I CE  1 
ATOM   5063 N  N   . CYS E 2 35  A 16.375  -32.372 46.394  1.00 17.37  ? 35  CYS I N   1 
ATOM   5064 C  CA  . CYS E 2 35  A 16.388  -33.736 45.880  1.00 16.48  ? 35  CYS I CA  1 
ATOM   5065 C  C   . CYS E 2 35  A 17.798  -34.201 45.571  1.00 21.20  ? 35  CYS I C   1 
ATOM   5066 O  O   . CYS E 2 35  A 18.701  -33.383 45.352  1.00 21.97  ? 35  CYS I O   1 
ATOM   5067 C  CB  . CYS E 2 35  A 15.513  -33.844 44.614  1.00 15.96  ? 35  CYS I CB  1 
ATOM   5068 S  SG  . CYS E 2 35  A 13.802  -33.189 44.758  1.00 22.58  ? 35  CYS I SG  1 
ATOM   5069 N  N   . TRP E 2 36  ? 17.985  -35.522 45.564  1.00 19.92  ? 36  TRP I N   1 
ATOM   5070 C  CA  . TRP E 2 36  ? 19.262  -36.104 45.186  1.00 12.25  ? 36  TRP I CA  1 
ATOM   5071 C  C   . TRP E 2 36  ? 19.100  -36.881 43.874  1.00 17.06  ? 36  TRP I C   1 
ATOM   5072 O  O   . TRP E 2 36  ? 18.086  -37.577 43.653  1.00 16.09  ? 36  TRP I O   1 
ATOM   5073 C  CB  . TRP E 2 36  ? 19.782  -37.038 46.287  1.00 18.94  ? 36  TRP I CB  1 
ATOM   5074 C  CG  . TRP E 2 36  ? 20.320  -36.355 47.539  1.00 17.92  ? 36  TRP I CG  1 
ATOM   5075 C  CD1 . TRP E 2 36  ? 19.616  -36.027 48.664  1.00 17.21  ? 36  TRP I CD1 1 
ATOM   5076 C  CD2 . TRP E 2 36  ? 21.685  -35.968 47.794  1.00 15.11  ? 36  TRP I CD2 1 
ATOM   5077 N  NE1 . TRP E 2 36  ? 20.455  -35.444 49.594  1.00 20.08  ? 36  TRP I NE1 1 
ATOM   5078 C  CE2 . TRP E 2 36  ? 21.725  -35.392 49.083  1.00 17.19  ? 36  TRP I CE2 1 
ATOM   5079 C  CE3 . TRP E 2 36  ? 22.870  -36.043 47.049  1.00 17.52  ? 36  TRP I CE3 1 
ATOM   5080 C  CZ2 . TRP E 2 36  ? 22.903  -34.909 49.651  1.00 18.13  ? 36  TRP I CZ2 1 
ATOM   5081 C  CZ3 . TRP E 2 36  ? 24.048  -35.557 47.611  1.00 19.22  ? 36  TRP I CZ3 1 
ATOM   5082 C  CH2 . TRP E 2 36  ? 24.055  -34.993 48.900  1.00 17.65  ? 36  TRP I CH2 1 
ATOM   5083 N  N   . VAL E 2 37  ? 20.110  -36.756 43.015  1.00 16.73  ? 37  VAL I N   1 
ATOM   5084 C  CA  . VAL E 2 37  ? 20.136  -37.376 41.692  1.00 14.35  ? 37  VAL I CA  1 
ATOM   5085 C  C   . VAL E 2 37  ? 21.531  -37.964 41.498  1.00 16.00  ? 37  VAL I C   1 
ATOM   5086 O  O   . VAL E 2 37  ? 22.517  -37.334 41.891  1.00 20.36  ? 37  VAL I O   1 
ATOM   5087 C  CB  . VAL E 2 37  ? 19.877  -36.336 40.570  1.00 15.51  ? 37  VAL I CB  1 
ATOM   5088 C  CG1 . VAL E 2 37  ? 20.094  -36.972 39.182  1.00 15.83  ? 37  VAL I CG1 1 
ATOM   5089 C  CG2 . VAL E 2 37  ? 18.455  -35.757 40.678  1.00 14.85  ? 37  VAL I CG2 1 
ATOM   5090 N  N   . ARG E 2 38  ? 21.643  -39.153 40.913  1.00 16.34  ? 38  ARG I N   1 
ATOM   5091 C  CA  . ARG E 2 38  ? 22.980  -39.721 40.691  1.00 15.63  ? 38  ARG I CA  1 
ATOM   5092 C  C   . ARG E 2 38  ? 23.219  -40.083 39.238  1.00 17.26  ? 38  ARG I C   1 
ATOM   5093 O  O   . ARG E 2 38  ? 22.279  -40.156 38.448  1.00 15.30  ? 38  ARG I O   1 
ATOM   5094 C  CB  . ARG E 2 38  ? 23.225  -40.932 41.595  1.00 16.47  ? 38  ARG I CB  1 
ATOM   5095 C  CG  . ARG E 2 38  ? 22.507  -42.214 41.156  1.00 18.69  ? 38  ARG I CG  1 
ATOM   5096 C  CD  . ARG E 2 38  ? 22.769  -43.390 42.122  1.00 14.79  ? 38  ARG I CD  1 
ATOM   5097 N  NE  . ARG E 2 38  ? 22.041  -44.594 41.682  1.00 17.76  ? 38  ARG I NE  1 
ATOM   5098 C  CZ  . ARG E 2 38  ? 22.011  -45.752 42.347  1.00 21.02  ? 38  ARG I CZ  1 
ATOM   5099 N  NH1 . ARG E 2 38  ? 22.656  -45.895 43.508  1.00 16.22  ? 38  ARG I NH1 1 
ATOM   5100 N  NH2 . ARG E 2 38  ? 21.325  -46.775 41.858  1.00 18.55  ? 38  ARG I NH2 1 
ATOM   5101 N  N   . GLN E 2 39  ? 24.491  -40.301 38.897  1.00 18.28  ? 39  GLN I N   1 
ATOM   5102 C  CA  . GLN E 2 39  ? 24.907  -40.592 37.527  1.00 16.74  ? 39  GLN I CA  1 
ATOM   5103 C  C   . GLN E 2 39  ? 26.128  -41.522 37.537  1.00 20.70  ? 39  GLN I C   1 
ATOM   5104 O  O   . GLN E 2 39  ? 27.228  -41.126 37.973  1.00 17.35  ? 39  GLN I O   1 
ATOM   5105 C  CB  . GLN E 2 39  ? 25.237  -39.273 36.810  1.00 18.20  ? 39  GLN I CB  1 
ATOM   5106 C  CG  . GLN E 2 39  ? 25.723  -39.381 35.358  1.00 18.02  ? 39  GLN I CG  1 
ATOM   5107 C  CD  . GLN E 2 39  ? 25.688  -38.027 34.616  1.00 18.77  ? 39  GLN I CD  1 
ATOM   5108 O  OE1 . GLN E 2 39  ? 26.182  -37.014 35.120  1.00 19.88  ? 39  GLN I OE1 1 
ATOM   5109 N  NE2 . GLN E 2 39  ? 25.087  -38.014 33.420  1.00 16.56  ? 39  GLN I NE2 1 
ATOM   5110 N  N   . ALA E 2 40  ? 25.949  -42.758 37.075  1.00 22.32  ? 40  ALA I N   1 
ATOM   5111 C  CA  . ALA E 2 40  ? 27.077  -43.684 36.975  1.00 19.67  ? 40  ALA I CA  1 
ATOM   5112 C  C   . ALA E 2 40  ? 28.009  -43.232 35.857  1.00 24.00  ? 40  ALA I C   1 
ATOM   5113 O  O   . ALA E 2 40  ? 27.562  -42.603 34.906  1.00 23.62  ? 40  ALA I O   1 
ATOM   5114 C  CB  . ALA E 2 40  ? 26.590  -45.106 36.720  1.00 21.87  ? 40  ALA I CB  1 
ATOM   5115 N  N   . PRO E 2 41  ? 29.311  -43.557 35.961  1.00 28.13  ? 41  PRO I N   1 
ATOM   5116 C  CA  . PRO E 2 41  ? 30.262  -43.126 34.926  1.00 24.79  ? 41  PRO I CA  1 
ATOM   5117 C  C   . PRO E 2 41  ? 29.807  -43.488 33.511  1.00 23.88  ? 41  PRO I C   1 
ATOM   5118 O  O   . PRO E 2 41  ? 29.568  -44.655 33.198  1.00 24.42  ? 41  PRO I O   1 
ATOM   5119 C  CB  . PRO E 2 41  ? 31.543  -43.883 35.297  1.00 30.04  ? 41  PRO I CB  1 
ATOM   5120 C  CG  . PRO E 2 41  ? 31.455  -44.051 36.783  1.00 23.91  ? 41  PRO I CG  1 
ATOM   5121 C  CD  . PRO E 2 41  ? 29.979  -44.285 37.059  1.00 25.42  ? 41  PRO I CD  1 
ATOM   5122 N  N   . GLY E 2 42  ? 29.640  -42.472 32.673  1.00 27.04  ? 42  GLY I N   1 
ATOM   5123 C  CA  . GLY E 2 42  ? 29.210  -42.682 31.297  1.00 31.24  ? 42  GLY I CA  1 
ATOM   5124 C  C   . GLY E 2 42  ? 27.732  -42.982 31.089  1.00 31.72  ? 42  GLY I C   1 
ATOM   5125 O  O   . GLY E 2 42  ? 27.307  -43.325 29.985  1.00 28.15  ? 42  GLY I O   1 
ATOM   5126 N  N   . LYS E 2 43  ? 26.938  -42.866 32.148  1.00 27.69  ? 43  LYS I N   1 
ATOM   5127 C  CA  . LYS E 2 43  ? 25.523  -43.216 32.058  1.00 25.89  ? 43  LYS I CA  1 
ATOM   5128 C  C   . LYS E 2 43  ? 24.626  -41.992 32.278  1.00 23.48  ? 43  LYS I C   1 
ATOM   5129 O  O   . LYS E 2 43  ? 25.114  -40.856 32.352  1.00 20.78  ? 43  LYS I O   1 
ATOM   5130 C  CB  . LYS E 2 43  ? 25.167  -44.346 33.047  1.00 21.50  ? 43  LYS I CB  1 
ATOM   5131 C  CG  . LYS E 2 43  ? 25.986  -45.624 32.858  1.00 30.01  ? 43  LYS I CG  1 
ATOM   5132 C  CD  . LYS E 2 43  ? 26.068  -46.022 31.390  1.00 43.61  ? 43  LYS I CD  1 
ATOM   5133 C  CE  . LYS E 2 43  ? 26.846  -47.324 31.196  1.00 59.23  ? 43  LYS I CE  1 
ATOM   5134 N  NZ  . LYS E 2 43  ? 26.947  -47.715 29.753  1.00 59.16  ? 43  LYS I NZ  1 
ATOM   5135 N  N   . GLY E 2 44  ? 23.318  -42.233 32.377  1.00 16.31  ? 44  GLY I N   1 
ATOM   5136 C  CA  . GLY E 2 44  ? 22.348  -41.161 32.447  1.00 19.55  ? 44  GLY I CA  1 
ATOM   5137 C  C   . GLY E 2 44  ? 22.006  -40.764 33.870  1.00 24.44  ? 44  GLY I C   1 
ATOM   5138 O  O   . GLY E 2 44  ? 22.474  -41.392 34.819  1.00 21.30  ? 44  GLY I O   1 
ATOM   5139 N  N   . LEU E 2 45  ? 21.185  -39.720 34.004  1.00 13.63  ? 45  LEU I N   1 
ATOM   5140 C  CA  . LEU E 2 45  ? 20.747  -39.224 35.293  1.00 17.44  ? 45  LEU I CA  1 
ATOM   5141 C  C   . LEU E 2 45  ? 19.668  -40.143 35.880  1.00 14.39  ? 45  LEU I C   1 
ATOM   5142 O  O   . LEU E 2 45  ? 18.826  -40.644 35.146  1.00 19.14  ? 45  LEU I O   1 
ATOM   5143 C  CB  . LEU E 2 45  ? 20.177  -37.809 35.132  1.00 13.17  ? 45  LEU I CB  1 
ATOM   5144 C  CG  . LEU E 2 45  ? 21.114  -36.703 34.633  1.00 16.23  ? 45  LEU I CG  1 
ATOM   5145 C  CD1 . LEU E 2 45  ? 20.331  -35.434 34.378  1.00 17.09  ? 45  LEU I CD1 1 
ATOM   5146 C  CD2 . LEU E 2 45  ? 22.249  -36.432 35.627  1.00 13.12  ? 45  LEU I CD2 1 
ATOM   5147 N  N   . GLU E 2 46  ? 19.686  -40.335 37.194  1.00 14.60  ? 46  GLU I N   1 
ATOM   5148 C  CA  . GLU E 2 46  ? 18.710  -41.198 37.880  1.00 15.02  ? 46  GLU I CA  1 
ATOM   5149 C  C   . GLU E 2 46  ? 18.246  -40.554 39.193  1.00 20.16  ? 46  GLU I C   1 
ATOM   5150 O  O   . GLU E 2 46  ? 19.067  -40.223 40.062  1.00 19.88  ? 46  GLU I O   1 
ATOM   5151 C  CB  . GLU E 2 46  ? 19.329  -42.588 38.144  1.00 14.17  ? 46  GLU I CB  1 
ATOM   5152 C  CG  . GLU E 2 46  ? 18.411  -43.598 38.853  1.00 16.24  ? 46  GLU I CG  1 
ATOM   5153 C  CD  . GLU E 2 46  ? 19.070  -44.978 39.022  1.00 24.25  ? 46  GLU I CD  1 
ATOM   5154 O  OE1 . GLU E 2 46  ? 20.242  -45.044 39.454  1.00 17.28  ? 46  GLU I OE1 1 
ATOM   5155 O  OE2 . GLU E 2 46  ? 18.408  -45.993 38.716  1.00 19.19  ? 46  GLU I OE2 1 
ATOM   5156 N  N   . TRP E 2 47  ? 16.937  -40.360 39.330  1.00 14.10  ? 47  TRP I N   1 
ATOM   5157 C  CA  . TRP E 2 47  ? 16.366  -39.719 40.512  1.00 16.03  ? 47  TRP I CA  1 
ATOM   5158 C  C   . TRP E 2 47  ? 16.446  -40.673 41.698  1.00 16.78  ? 47  TRP I C   1 
ATOM   5159 O  O   . TRP E 2 47  ? 16.122  -41.862 41.559  1.00 14.37  ? 47  TRP I O   1 
ATOM   5160 C  CB  . TRP E 2 47  ? 14.892  -39.374 40.253  1.00 13.99  ? 47  TRP I CB  1 
ATOM   5161 C  CG  . TRP E 2 47  ? 14.217  -38.738 41.446  1.00 15.46  ? 47  TRP I CG  1 
ATOM   5162 C  CD1 . TRP E 2 47  ? 14.571  -37.563 42.065  1.00 15.71  ? 47  TRP I CD1 1 
ATOM   5163 C  CD2 . TRP E 2 47  ? 13.060  -39.222 42.142  1.00 14.19  ? 47  TRP I CD2 1 
ATOM   5164 N  NE1 . TRP E 2 47  ? 13.712  -37.303 43.112  1.00 16.76  ? 47  TRP I NE1 1 
ATOM   5165 C  CE2 . TRP E 2 47  ? 12.774  -38.303 43.176  1.00 15.82  ? 47  TRP I CE2 1 
ATOM   5166 C  CE3 . TRP E 2 47  ? 12.241  -40.348 41.997  1.00 16.36  ? 47  TRP I CE3 1 
ATOM   5167 C  CZ2 . TRP E 2 47  ? 11.702  -38.475 44.056  1.00 18.30  ? 47  TRP I CZ2 1 
ATOM   5168 C  CZ3 . TRP E 2 47  ? 11.180  -40.518 42.878  1.00 15.64  ? 47  TRP I CZ3 1 
ATOM   5169 C  CH2 . TRP E 2 47  ? 10.921  -39.591 43.890  1.00 17.05  ? 47  TRP I CH2 1 
ATOM   5170 N  N   . ILE E 2 48  ? 16.860  -40.157 42.853  1.00 16.06  ? 48  ILE I N   1 
ATOM   5171 C  CA  . ILE E 2 48  ? 16.922  -40.951 44.081  1.00 16.00  ? 48  ILE I CA  1 
ATOM   5172 C  C   . ILE E 2 48  ? 15.746  -40.683 45.029  1.00 14.52  ? 48  ILE I C   1 
ATOM   5173 O  O   . ILE E 2 48  ? 15.082  -41.632 45.477  1.00 14.60  ? 48  ILE I O   1 
ATOM   5174 C  CB  . ILE E 2 48  ? 18.236  -40.713 44.857  1.00 18.34  ? 48  ILE I CB  1 
ATOM   5175 C  CG1 . ILE E 2 48  ? 19.454  -41.094 43.997  1.00 14.31  ? 48  ILE I CG1 1 
ATOM   5176 C  CG2 . ILE E 2 48  ? 18.196  -41.502 46.174  1.00 17.26  ? 48  ILE I CG2 1 
ATOM   5177 C  CD1 . ILE E 2 48  ? 20.783  -40.642 44.585  1.00 16.64  ? 48  ILE I CD1 1 
ATOM   5178 N  N   . GLY E 2 49  ? 15.515  -39.403 45.358  1.00 13.19  ? 49  GLY I N   1 
ATOM   5179 C  CA  . GLY E 2 49  ? 14.459  -39.020 46.282  1.00 13.96  ? 49  GLY I CA  1 
ATOM   5180 C  C   . GLY E 2 49  ? 14.457  -37.527 46.577  1.00 17.44  ? 49  GLY I C   1 
ATOM   5181 O  O   . GLY E 2 49  ? 15.329  -36.809 46.101  1.00 14.45  ? 49  GLY I O   1 
ATOM   5182 N  N   . CYS E 2 50  ? 13.478  -37.065 47.355  1.00 18.68  ? 50  CYS I N   1 
ATOM   5183 C  CA  . CYS E 2 50  ? 13.354  -35.644 47.729  1.00 17.66  ? 50  CYS I CA  1 
ATOM   5184 C  C   . CYS E 2 50  ? 12.905  -35.463 49.181  1.00 24.45  ? 50  CYS I C   1 
ATOM   5185 O  O   . CYS E 2 50  ? 12.243  -36.345 49.767  1.00 17.83  ? 50  CYS I O   1 
ATOM   5186 C  CB  . CYS E 2 50  ? 12.304  -34.921 46.865  1.00 18.02  ? 50  CYS I CB  1 
ATOM   5187 S  SG  . CYS E 2 50  ? 12.561  -34.778 45.064  1.00 21.03  ? 50  CYS I SG  1 
ATOM   5188 N  N   . ILE E 2 51  ? 13.244  -34.303 49.745  1.00 19.79  ? 51  ILE I N   1 
ATOM   5189 C  CA  . ILE E 2 51  ? 12.623  -33.821 50.973  1.00 21.79  ? 51  ILE I CA  1 
ATOM   5190 C  C   . ILE E 2 51  ? 12.114  -32.380 50.768  1.00 20.36  ? 51  ILE I C   1 
ATOM   5191 O  O   . ILE E 2 51  ? 12.850  -31.524 50.303  1.00 19.19  ? 51  ILE I O   1 
ATOM   5192 C  CB  . ILE E 2 51  ? 13.601  -33.901 52.181  1.00 19.68  ? 51  ILE I CB  1 
ATOM   5193 C  CG1 . ILE E 2 51  ? 12.925  -33.434 53.464  1.00 25.82  ? 51  ILE I CG1 1 
ATOM   5194 C  CG2 . ILE E 2 51  ? 14.888  -33.107 51.940  1.00 21.28  ? 51  ILE I CG2 1 
ATOM   5195 C  CD1 . ILE E 2 51  ? 12.322  -34.557 54.267  1.00 21.20  ? 51  ILE I CD1 1 
ATOM   5196 N  N   . GLU E 2 52  ? 10.849  -32.121 51.080  1.00 15.77  ? 52  GLU I N   1 
ATOM   5197 C  CA  . GLU E 2 52  ? 10.332  -30.753 51.115  1.00 22.12  ? 52  GLU I CA  1 
ATOM   5198 C  C   . GLU E 2 52  ? 10.782  -30.057 52.383  1.00 26.24  ? 52  GLU I C   1 
ATOM   5199 O  O   . GLU E 2 52  ? 10.678  -30.620 53.464  1.00 26.58  ? 52  GLU I O   1 
ATOM   5200 C  CB  . GLU E 2 52  ? 8.810   -30.747 51.161  1.00 29.80  ? 52  GLU I CB  1 
ATOM   5201 C  CG  . GLU E 2 52  ? 8.102   -31.150 49.899  1.00 28.57  ? 52  GLU I CG  1 
ATOM   5202 C  CD  . GLU E 2 52  ? 6.610   -31.062 50.093  1.00 43.52  ? 52  GLU I CD  1 
ATOM   5203 O  OE1 . GLU E 2 52  ? 6.139   -31.537 51.153  1.00 41.41  ? 52  GLU I OE1 1 
ATOM   5204 O  OE2 . GLU E 2 52  ? 5.919   -30.488 49.224  1.00 39.50  ? 52  GLU I OE2 1 
ATOM   5205 N  N   . THR E 2 53  A 11.224  -28.813 52.272  1.00 22.40  ? 52  THR I N   1 
ATOM   5206 C  CA  . THR E 2 53  A 11.663  -28.088 53.457  1.00 27.25  ? 52  THR I CA  1 
ATOM   5207 C  C   . THR E 2 53  A 10.575  -27.139 53.986  1.00 39.14  ? 52  THR I C   1 
ATOM   5208 O  O   . THR E 2 53  A 10.787  -26.400 54.956  1.00 41.68  ? 52  THR I O   1 
ATOM   5209 C  CB  . THR E 2 53  A 12.970  -27.327 53.193  1.00 31.65  ? 52  THR I CB  1 
ATOM   5210 O  OG1 . THR E 2 53  A 12.746  -26.334 52.187  1.00 28.45  ? 52  THR I OG1 1 
ATOM   5211 C  CG2 . THR E 2 53  A 14.036  -28.286 52.723  1.00 28.20  ? 52  THR I CG2 1 
ATOM   5212 N  N   . GLY E 2 54  B 9.411   -27.174 53.345  1.00 31.56  ? 52  GLY I N   1 
ATOM   5213 C  CA  . GLY E 2 54  B 8.227   -26.497 53.843  1.00 48.29  ? 52  GLY I CA  1 
ATOM   5214 C  C   . GLY E 2 54  B 7.236   -27.417 54.555  1.00 49.27  ? 52  GLY I C   1 
ATOM   5215 O  O   . GLY E 2 54  B 7.544   -28.580 54.853  1.00 44.04  ? 52  GLY I O   1 
ATOM   5216 N  N   . SER E 2 55  ? 6.033   -26.888 54.786  1.00 43.55  ? 53  SER I N   1 
ATOM   5217 C  CA  . SER E 2 55  ? 5.026   -27.420 55.730  1.00 46.61  ? 53  SER I CA  1 
ATOM   5218 C  C   . SER E 2 55  ? 4.762   -28.932 55.820  1.00 58.84  ? 53  SER I C   1 
ATOM   5219 O  O   . SER E 2 55  ? 4.748   -29.491 56.921  1.00 61.05  ? 53  SER I O   1 
ATOM   5220 C  CB  . SER E 2 55  ? 3.689   -26.692 55.534  1.00 57.81  ? 53  SER I CB  1 
ATOM   5221 O  OG  . SER E 2 55  ? 3.772   -25.344 55.964  1.00 69.50  ? 53  SER I OG  1 
ATOM   5222 N  N   . SER E 2 56  ? 4.512   -29.593 54.694  1.00 47.51  ? 54  SER I N   1 
ATOM   5223 C  CA  . SER E 2 56  ? 4.229   -31.026 54.755  1.00 47.56  ? 54  SER I CA  1 
ATOM   5224 C  C   . SER E 2 56  ? 5.470   -31.852 55.158  1.00 53.80  ? 54  SER I C   1 
ATOM   5225 O  O   . SER E 2 56  ? 5.332   -32.985 55.642  1.00 39.41  ? 54  SER I O   1 
ATOM   5226 C  CB  . SER E 2 56  ? 3.627   -31.532 53.441  1.00 56.08  ? 54  SER I CB  1 
ATOM   5227 O  OG  . SER E 2 56  ? 4.521   -31.346 52.357  1.00 49.85  ? 54  SER I OG  1 
ATOM   5228 N  N   . ASP E 2 57  ? 6.661   -31.255 55.004  1.00 31.98  ? 55  ASP I N   1 
ATOM   5229 C  CA  . ASP E 2 57  ? 7.957   -31.934 55.215  1.00 31.42  ? 55  ASP I CA  1 
ATOM   5230 C  C   . ASP E 2 57  ? 7.996   -33.376 54.703  1.00 25.36  ? 55  ASP I C   1 
ATOM   5231 O  O   . ASP E 2 57  ? 8.491   -34.282 55.382  1.00 22.25  ? 55  ASP I O   1 
ATOM   5232 C  CB  . ASP E 2 57  ? 8.426   -31.888 56.675  1.00 30.96  ? 55  ASP I CB  1 
ATOM   5233 C  CG  . ASP E 2 57  ? 7.350   -31.448 57.632  1.00 45.01  ? 55  ASP I CG  1 
ATOM   5234 O  OD1 . ASP E 2 57  ? 7.326   -30.242 57.982  1.00 42.52  ? 55  ASP I OD1 1 
ATOM   5235 O  OD2 . ASP E 2 57  ? 6.540   -32.309 58.043  1.00 41.66  ? 55  ASP I OD2 1 
ATOM   5236 N  N   . SER E 2 58  ? 7.469   -33.568 53.501  1.00 18.71  ? 56  SER I N   1 
ATOM   5237 C  CA  . SER E 2 58  ? 7.373   -34.883 52.904  1.00 21.56  ? 56  SER I CA  1 
ATOM   5238 C  C   . SER E 2 58  ? 8.699   -35.371 52.319  1.00 22.01  ? 56  SER I C   1 
ATOM   5239 O  O   . SER E 2 58  ? 9.323   -34.681 51.522  1.00 20.71  ? 56  SER I O   1 
ATOM   5240 C  CB  . SER E 2 58  ? 6.303   -34.872 51.807  1.00 23.82  ? 56  SER I CB  1 
ATOM   5241 O  OG  . SER E 2 58  ? 6.396   -36.045 51.009  1.00 25.87  ? 56  SER I OG  1 
ATOM   5242 N  N   . ALA E 2 59  ? 9.099   -36.573 52.720  1.00 19.53  ? 57  ALA I N   1 
ATOM   5243 C  CA  . ALA E 2 59  ? 10.152  -37.333 52.069  1.00 18.05  ? 57  ALA I CA  1 
ATOM   5244 C  C   . ALA E 2 59  ? 9.512   -38.348 51.106  1.00 17.78  ? 57  ALA I C   1 
ATOM   5245 O  O   . ALA E 2 59  ? 8.533   -39.003 51.458  1.00 17.93  ? 57  ALA I O   1 
ATOM   5246 C  CB  . ALA E 2 59  ? 10.984  -38.093 53.130  1.00 14.99  ? 57  ALA I CB  1 
ATOM   5247 N  N   . ALA E 2 60  ? 10.076  -38.491 49.915  1.00 14.84  ? 58  ALA I N   1 
ATOM   5248 C  CA  . ALA E 2 60  ? 9.605   -39.474 48.930  1.00 14.81  ? 58  ALA I CA  1 
ATOM   5249 C  C   . ALA E 2 60  ? 10.802  -40.048 48.184  1.00 18.18  ? 58  ALA I C   1 
ATOM   5250 O  O   . ALA E 2 60  ? 11.805  -39.353 47.997  1.00 15.34  ? 58  ALA I O   1 
ATOM   5251 C  CB  . ALA E 2 60  ? 8.639   -38.820 47.941  1.00 18.87  ? 58  ALA I CB  1 
ATOM   5252 N  N   . TYR E 2 61  ? 10.684  -41.291 47.718  1.00 17.36  ? 59  TYR I N   1 
ATOM   5253 C  CA  . TYR E 2 61  ? 11.832  -41.988 47.138  1.00 18.10  ? 59  TYR I CA  1 
ATOM   5254 C  C   . TYR E 2 61  ? 11.469  -42.704 45.838  1.00 19.94  ? 59  TYR I C   1 
ATOM   5255 O  O   . TYR E 2 61  ? 10.307  -43.058 45.621  1.00 15.90  ? 59  TYR I O   1 
ATOM   5256 C  CB  . TYR E 2 61  ? 12.402  -43.003 48.144  1.00 14.08  ? 59  TYR I CB  1 
ATOM   5257 C  CG  . TYR E 2 61  ? 12.793  -42.362 49.465  1.00 16.75  ? 59  TYR I CG  1 
ATOM   5258 C  CD1 . TYR E 2 61  ? 11.869  -42.230 50.504  1.00 14.49  ? 59  TYR I CD1 1 
ATOM   5259 C  CD2 . TYR E 2 61  ? 14.073  -41.849 49.652  1.00 15.45  ? 59  TYR I CD2 1 
ATOM   5260 C  CE1 . TYR E 2 61  ? 12.222  -41.610 51.708  1.00 19.89  ? 59  TYR I CE1 1 
ATOM   5261 C  CE2 . TYR E 2 61  ? 14.446  -41.246 50.843  1.00 15.66  ? 59  TYR I CE2 1 
ATOM   5262 C  CZ  . TYR E 2 61  ? 13.521  -41.121 51.866  1.00 18.09  ? 59  TYR I CZ  1 
ATOM   5263 O  OH  . TYR E 2 61  ? 13.905  -40.516 53.033  1.00 16.46  ? 59  TYR I OH  1 
ATOM   5264 N  N   . ALA E 2 62  ? 12.464  -42.932 44.983  1.00 16.50  ? 60  ALA I N   1 
ATOM   5265 C  CA  . ALA E 2 62  ? 12.291  -43.890 43.886  1.00 18.07  ? 60  ALA I CA  1 
ATOM   5266 C  C   . ALA E 2 62  ? 12.027  -45.277 44.496  1.00 18.15  ? 60  ALA I C   1 
ATOM   5267 O  O   . ALA E 2 62  ? 12.521  -45.592 45.593  1.00 15.64  ? 60  ALA I O   1 
ATOM   5268 C  CB  . ALA E 2 62  ? 13.520  -43.918 42.993  1.00 15.44  ? 60  ALA I CB  1 
ATOM   5269 N  N   . THR E 2 63  ? 11.243  -46.101 43.808  1.00 18.88  ? 61  THR I N   1 
ATOM   5270 C  CA  . THR E 2 63  ? 10.987  -47.449 44.320  1.00 18.33  ? 61  THR I CA  1 
ATOM   5271 C  C   . THR E 2 63  ? 12.274  -48.213 44.642  1.00 16.77  ? 61  THR I C   1 
ATOM   5272 O  O   . THR E 2 63  ? 12.372  -48.854 45.697  1.00 18.35  ? 61  THR I O   1 
ATOM   5273 C  CB  . THR E 2 63  ? 10.069  -48.257 43.386  1.00 23.79  ? 61  THR I CB  1 
ATOM   5274 O  OG1 . THR E 2 63  ? 8.742   -47.720 43.464  1.00 19.96  ? 61  THR I OG1 1 
ATOM   5275 C  CG2 . THR E 2 63  ? 10.025  -49.726 43.807  1.00 24.71  ? 61  THR I CG2 1 
ATOM   5276 N  N   . TRP E 2 64  ? 13.276  -48.127 43.766  1.00 18.78  ? 62  TRP I N   1 
ATOM   5277 C  CA  . TRP E 2 64  ? 14.531  -48.876 44.012  1.00 20.36  ? 62  TRP I CA  1 
ATOM   5278 C  C   . TRP E 2 64  ? 15.259  -48.437 45.290  1.00 24.84  ? 62  TRP I C   1 
ATOM   5279 O  O   . TRP E 2 64  ? 15.929  -49.247 45.944  1.00 21.09  ? 62  TRP I O   1 
ATOM   5280 C  CB  . TRP E 2 64  ? 15.484  -48.836 42.801  1.00 18.09  ? 62  TRP I CB  1 
ATOM   5281 C  CG  . TRP E 2 64  ? 15.997  -47.462 42.476  1.00 19.06  ? 62  TRP I CG  1 
ATOM   5282 C  CD1 . TRP E 2 64  ? 15.477  -46.597 41.580  1.00 15.40  ? 62  TRP I CD1 1 
ATOM   5283 C  CD2 . TRP E 2 64  ? 17.126  -46.799 43.069  1.00 19.40  ? 62  TRP I CD2 1 
ATOM   5284 N  NE1 . TRP E 2 64  ? 16.204  -45.423 41.567  1.00 16.44  ? 62  TRP I NE1 1 
ATOM   5285 C  CE2 . TRP E 2 64  ? 17.223  -45.528 42.475  1.00 18.35  ? 62  TRP I CE2 1 
ATOM   5286 C  CE3 . TRP E 2 64  ? 18.056  -47.163 44.047  1.00 16.54  ? 62  TRP I CE3 1 
ATOM   5287 C  CZ2 . TRP E 2 64  ? 18.230  -44.612 42.815  1.00 15.78  ? 62  TRP I CZ2 1 
ATOM   5288 C  CZ3 . TRP E 2 64  ? 19.055  -46.264 44.383  1.00 22.49  ? 62  TRP I CZ3 1 
ATOM   5289 C  CH2 . TRP E 2 64  ? 19.128  -44.991 43.767  1.00 16.95  ? 62  TRP I CH2 1 
ATOM   5290 N  N   . ALA E 2 65  ? 15.111  -47.163 45.654  1.00 15.65  ? 63  ALA I N   1 
ATOM   5291 C  CA  . ALA E 2 65  ? 15.819  -46.596 46.809  1.00 14.52  ? 63  ALA I CA  1 
ATOM   5292 C  C   . ALA E 2 65  ? 15.063  -46.714 48.143  1.00 16.08  ? 63  ALA I C   1 
ATOM   5293 O  O   . ALA E 2 65  ? 15.665  -46.648 49.227  1.00 16.35  ? 63  ALA I O   1 
ATOM   5294 C  CB  . ALA E 2 65  ? 16.127  -45.139 46.542  1.00 14.71  ? 63  ALA I CB  1 
ATOM   5295 N  N   . LYS E 2 66  ? 13.741  -46.832 48.047  1.00 15.43  ? 64  LYS I N   1 
ATOM   5296 C  CA  . LYS E 2 66  ? 12.856  -46.784 49.212  1.00 13.89  ? 64  LYS I CA  1 
ATOM   5297 C  C   . LYS E 2 66  ? 13.246  -47.836 50.237  1.00 17.04  ? 64  LYS I C   1 
ATOM   5298 O  O   . LYS E 2 66  ? 13.362  -49.009 49.896  1.00 14.28  ? 64  LYS I O   1 
ATOM   5299 C  CB  . LYS E 2 66  ? 11.404  -47.009 48.759  1.00 16.19  ? 64  LYS I CB  1 
ATOM   5300 C  CG  . LYS E 2 66  ? 10.361  -46.838 49.854  1.00 20.04  ? 64  LYS I CG  1 
ATOM   5301 C  CD  . LYS E 2 66  ? 8.971   -47.204 49.327  1.00 23.37  ? 64  LYS I CD  1 
ATOM   5302 C  CE  . LYS E 2 66  ? 7.989   -47.400 50.460  1.00 31.50  ? 64  LYS I CE  1 
ATOM   5303 N  NZ  . LYS E 2 66  ? 6.625   -47.705 49.944  1.00 28.34  ? 64  LYS I NZ  1 
ATOM   5304 N  N   . GLY E 2 67  ? 13.456  -47.413 51.484  1.00 19.27  ? 65  GLY I N   1 
ATOM   5305 C  CA  . GLY E 2 67  ? 13.847  -48.328 52.552  1.00 17.24  ? 65  GLY I CA  1 
ATOM   5306 C  C   . GLY E 2 67  ? 15.339  -48.570 52.720  1.00 19.50  ? 65  GLY I C   1 
ATOM   5307 O  O   . GLY E 2 67  ? 15.786  -48.980 53.787  1.00 21.59  ? 65  GLY I O   1 
ATOM   5308 N  N   . ARG E 2 68  ? 16.126  -48.319 51.677  1.00 21.27  ? 66  ARG I N   1 
ATOM   5309 C  CA  . ARG E 2 68  ? 17.574  -48.529 51.772  1.00 20.32  ? 66  ARG I CA  1 
ATOM   5310 C  C   . ARG E 2 68  ? 18.323  -47.202 51.953  1.00 20.16  ? 66  ARG I C   1 
ATOM   5311 O  O   . ARG E 2 68  ? 19.353  -47.150 52.619  1.00 22.42  ? 66  ARG I O   1 
ATOM   5312 C  CB  . ARG E 2 68  ? 18.106  -49.307 50.553  1.00 20.47  ? 66  ARG I CB  1 
ATOM   5313 C  CG  . ARG E 2 68  ? 19.625  -49.654 50.604  1.00 24.22  ? 66  ARG I CG  1 
ATOM   5314 C  CD  . ARG E 2 68  ? 20.002  -50.763 49.598  1.00 22.67  ? 66  ARG I CD  1 
ATOM   5315 N  NE  . ARG E 2 68  ? 19.974  -50.325 48.194  1.00 18.68  ? 66  ARG I NE  1 
ATOM   5316 C  CZ  . ARG E 2 68  ? 21.028  -49.839 47.536  1.00 23.81  ? 66  ARG I CZ  1 
ATOM   5317 N  NH1 . ARG E 2 68  ? 22.199  -49.714 48.144  1.00 18.73  ? 66  ARG I NH1 1 
ATOM   5318 N  NH2 . ARG E 2 68  ? 20.924  -49.477 46.261  1.00 19.40  ? 66  ARG I NH2 1 
ATOM   5319 N  N   . PHE E 2 69  ? 17.797  -46.130 51.369  1.00 20.94  ? 67  PHE I N   1 
ATOM   5320 C  CA  . PHE E 2 69  ? 18.372  -44.785 51.543  1.00 19.02  ? 67  PHE I CA  1 
ATOM   5321 C  C   . PHE E 2 69  ? 17.443  -43.878 52.352  1.00 18.57  ? 67  PHE I C   1 
ATOM   5322 O  O   . PHE E 2 69  ? 16.224  -44.042 52.292  1.00 21.87  ? 67  PHE I O   1 
ATOM   5323 C  CB  . PHE E 2 69  ? 18.592  -44.110 50.186  1.00 21.02  ? 67  PHE I CB  1 
ATOM   5324 C  CG  . PHE E 2 69  ? 19.640  -44.767 49.319  1.00 24.46  ? 67  PHE I CG  1 
ATOM   5325 C  CD1 . PHE E 2 69  ? 19.946  -44.234 48.081  1.00 23.33  ? 67  PHE I CD1 1 
ATOM   5326 C  CD2 . PHE E 2 69  ? 20.330  -45.899 49.742  1.00 28.62  ? 67  PHE I CD2 1 
ATOM   5327 C  CE1 . PHE E 2 69  ? 20.908  -44.817 47.272  1.00 19.07  ? 67  PHE I CE1 1 
ATOM   5328 C  CE2 . PHE E 2 69  ? 21.290  -46.492 48.939  1.00 25.81  ? 67  PHE I CE2 1 
ATOM   5329 C  CZ  . PHE E 2 69  ? 21.570  -45.947 47.694  1.00 25.38  ? 67  PHE I CZ  1 
ATOM   5330 N  N   . THR E 2 70  ? 18.000  -42.904 53.082  1.00 16.20  ? 68  THR I N   1 
ATOM   5331 C  CA  . THR E 2 70  ? 17.167  -41.840 53.660  1.00 15.60  ? 68  THR I CA  1 
ATOM   5332 C  C   . THR E 2 70  ? 17.635  -40.458 53.255  1.00 16.82  ? 68  THR I C   1 
ATOM   5333 O  O   . THR E 2 70  ? 18.829  -40.221 53.052  1.00 21.32  ? 68  THR I O   1 
ATOM   5334 C  CB  . THR E 2 70  ? 17.105  -41.848 55.208  1.00 15.71  ? 68  THR I CB  1 
ATOM   5335 O  OG1 . THR E 2 70  ? 18.376  -41.481 55.754  1.00 19.46  ? 68  THR I OG1 1 
ATOM   5336 C  CG2 . THR E 2 70  ? 16.671  -43.210 55.753  1.00 19.70  ? 68  THR I CG2 1 
ATOM   5337 N  N   . ILE E 2 71  ? 16.692  -39.531 53.189  1.00 18.68  ? 69  ILE I N   1 
ATOM   5338 C  CA  . ILE E 2 71  ? 17.022  -38.126 52.980  1.00 13.72  ? 69  ILE I CA  1 
ATOM   5339 C  C   . ILE E 2 71  ? 16.431  -37.306 54.120  1.00 18.97  ? 69  ILE I C   1 
ATOM   5340 O  O   . ILE E 2 71  ? 15.250  -37.449 54.445  1.00 19.25  ? 69  ILE I O   1 
ATOM   5341 C  CB  . ILE E 2 71  ? 16.489  -37.636 51.611  1.00 19.38  ? 69  ILE I CB  1 
ATOM   5342 C  CG1 . ILE E 2 71  ? 17.154  -38.439 50.487  1.00 20.10  ? 69  ILE I CG1 1 
ATOM   5343 C  CG2 . ILE E 2 71  ? 16.725  -36.112 51.427  1.00 16.28  ? 69  ILE I CG2 1 
ATOM   5344 C  CD1 . ILE E 2 71  ? 16.522  -38.214 49.097  1.00 20.99  ? 69  ILE I CD1 1 
ATOM   5345 N  N   . SER E 2 72  ? 17.234  -36.460 54.754  1.00 17.23  ? 70  SER I N   1 
ATOM   5346 C  CA  . SER E 2 72  ? 16.687  -35.680 55.859  1.00 20.00  ? 70  SER I CA  1 
ATOM   5347 C  C   . SER E 2 72  ? 17.325  -34.304 55.993  1.00 30.04  ? 70  SER I C   1 
ATOM   5348 O  O   . SER E 2 72  ? 18.484  -34.102 55.606  1.00 28.51  ? 70  SER I O   1 
ATOM   5349 C  CB  . SER E 2 72  ? 16.735  -36.471 57.185  1.00 20.79  ? 70  SER I CB  1 
ATOM   5350 O  OG  . SER E 2 72  ? 18.053  -36.780 57.575  1.00 28.35  ? 70  SER I OG  1 
ATOM   5351 N  N   . LYS E 2 73  ? 16.546  -33.358 56.512  1.00 21.44  ? 71  LYS I N   1 
ATOM   5352 C  CA  . LYS E 2 73  ? 17.020  -31.991 56.754  1.00 29.00  ? 71  LYS I CA  1 
ATOM   5353 C  C   . LYS E 2 73  ? 17.689  -31.922 58.124  1.00 32.27  ? 71  LYS I C   1 
ATOM   5354 O  O   . LYS E 2 73  ? 17.021  -32.076 59.145  1.00 38.09  ? 71  LYS I O   1 
ATOM   5355 C  CB  . LYS E 2 73  ? 15.835  -31.023 56.681  1.00 24.49  ? 71  LYS I CB  1 
ATOM   5356 C  CG  . LYS E 2 73  ? 16.112  -29.603 57.119  1.00 38.88  ? 71  LYS I CG  1 
ATOM   5357 C  CD  . LYS E 2 73  ? 14.833  -28.743 57.004  1.00 30.25  ? 71  LYS I CD  1 
ATOM   5358 C  CE  . LYS E 2 73  ? 13.720  -29.207 57.945  1.00 37.14  ? 71  LYS I CE  1 
ATOM   5359 N  NZ  . LYS E 2 73  ? 12.402  -28.502 57.756  1.00 36.31  ? 71  LYS I NZ  1 
ATOM   5360 N  N   . THR E 2 74  ? 19.004  -31.705 58.158  1.00 28.19  ? 72  THR I N   1 
ATOM   5361 C  CA  . THR E 2 74  ? 19.731  -31.731 59.435  1.00 24.12  ? 72  THR I CA  1 
ATOM   5362 C  C   . THR E 2 74  ? 20.102  -30.375 60.094  1.00 27.26  ? 72  THR I C   1 
ATOM   5363 O  O   . THR E 2 74  ? 20.636  -30.343 61.207  1.00 32.29  ? 72  THR I O   1 
ATOM   5364 C  CB  . THR E 2 74  ? 20.960  -32.649 59.363  1.00 29.81  ? 72  THR I CB  1 
ATOM   5365 O  OG1 . THR E 2 74  ? 21.968  -32.079 58.509  1.00 27.19  ? 72  THR I OG1 1 
ATOM   5366 C  CG2 . THR E 2 74  ? 20.550  -34.020 58.842  1.00 29.11  ? 72  THR I CG2 1 
ATOM   5367 N  N   . SER E 2 75  ? 19.826  -29.274 59.406  1.00 27.33  ? 73  SER I N   1 
ATOM   5368 C  CA  . SER E 2 75  ? 20.001  -27.923 59.944  1.00 24.24  ? 73  SER I CA  1 
ATOM   5369 C  C   . SER E 2 75  ? 19.417  -26.999 58.908  1.00 29.64  ? 73  SER I C   1 
ATOM   5370 O  O   . SER E 2 75  ? 19.039  -27.459 57.845  1.00 22.96  ? 73  SER I O   1 
ATOM   5371 C  CB  . SER E 2 75  ? 21.479  -27.576 60.143  1.00 33.27  ? 73  SER I CB  1 
ATOM   5372 O  OG  . SER E 2 75  ? 22.062  -27.096 58.938  1.00 32.41  ? 73  SER I OG  1 
ATOM   5373 N  N   . SER E 2 76  ? 19.361  -25.698 59.186  1.00 23.89  ? 74  SER I N   1 
ATOM   5374 C  CA  . SER E 2 76  ? 18.786  -24.766 58.227  1.00 26.88  ? 74  SER I CA  1 
ATOM   5375 C  C   . SER E 2 76  ? 19.595  -24.667 56.925  1.00 24.68  ? 74  SER I C   1 
ATOM   5376 O  O   . SER E 2 76  ? 19.103  -24.128 55.928  1.00 32.03  ? 74  SER I O   1 
ATOM   5377 C  CB  . SER E 2 76  ? 18.611  -23.377 58.855  1.00 30.24  ? 74  SER I CB  1 
ATOM   5378 O  OG  . SER E 2 76  ? 19.871  -22.846 59.213  1.00 32.04  ? 74  SER I OG  1 
ATOM   5379 N  N   . THR E 2 77  ? 20.819  -25.193 56.923  1.00 25.79  ? 75  THR I N   1 
ATOM   5380 C  CA  . THR E 2 77  ? 21.641  -25.187 55.709  1.00 27.35  ? 75  THR I CA  1 
ATOM   5381 C  C   . THR E 2 77  ? 22.221  -26.544 55.295  1.00 24.63  ? 75  THR I C   1 
ATOM   5382 O  O   . THR E 2 77  ? 23.094  -26.593 54.431  1.00 25.65  ? 75  THR I O   1 
ATOM   5383 C  CB  . THR E 2 77  ? 22.826  -24.196 55.827  1.00 26.58  ? 75  THR I CB  1 
ATOM   5384 O  OG1 . THR E 2 77  ? 23.633  -24.552 56.955  1.00 29.42  ? 75  THR I OG1 1 
ATOM   5385 C  CG2 . THR E 2 77  ? 22.326  -22.773 55.989  1.00 31.60  ? 75  THR I CG2 1 
ATOM   5386 N  N   . THR E 2 78  ? 21.767  -27.642 55.899  1.00 24.66  ? 76  THR I N   1 
ATOM   5387 C  CA  . THR E 2 78  ? 22.282  -28.960 55.501  1.00 25.08  ? 76  THR I CA  1 
ATOM   5388 C  C   . THR E 2 78  ? 21.189  -30.013 55.307  1.00 26.52  ? 76  THR I C   1 
ATOM   5389 O  O   . THR E 2 78  ? 20.314  -30.161 56.160  1.00 20.68  ? 76  THR I O   1 
ATOM   5390 C  CB  . THR E 2 78  ? 23.328  -29.527 56.510  1.00 29.61  ? 76  THR I CB  1 
ATOM   5391 O  OG1 . THR E 2 78  ? 22.753  -29.603 57.826  1.00 29.39  ? 76  THR I OG1 1 
ATOM   5392 C  CG2 . THR E 2 78  ? 24.597  -28.675 56.543  1.00 28.44  ? 76  THR I CG2 1 
ATOM   5393 N  N   . VAL E 2 79  ? 21.265  -30.742 54.189  1.00 24.18  ? 77  VAL I N   1 
ATOM   5394 C  CA  . VAL E 2 79  ? 20.429  -31.925 53.934  1.00 19.19  ? 77  VAL I CA  1 
ATOM   5395 C  C   . VAL E 2 79  ? 21.347  -33.119 53.678  1.00 24.55  ? 77  VAL I C   1 
ATOM   5396 O  O   . VAL E 2 79  ? 22.369  -32.988 52.988  1.00 23.11  ? 77  VAL I O   1 
ATOM   5397 C  CB  . VAL E 2 79  ? 19.482  -31.705 52.713  1.00 23.38  ? 77  VAL I CB  1 
ATOM   5398 C  CG1 . VAL E 2 79  ? 18.942  -33.036 52.181  1.00 24.41  ? 77  VAL I CG1 1 
ATOM   5399 C  CG2 . VAL E 2 79  ? 18.337  -30.799 53.100  1.00 26.84  ? 77  VAL I CG2 1 
ATOM   5400 N  N   . THR E 2 80  ? 21.019  -34.277 54.251  1.00 21.67  ? 78  THR I N   1 
ATOM   5401 C  CA  . THR E 2 80  ? 21.856  -35.452 54.064  1.00 16.42  ? 78  THR I CA  1 
ATOM   5402 C  C   . THR E 2 80  ? 21.201  -36.535 53.185  1.00 17.85  ? 78  THR I C   1 
ATOM   5403 O  O   . THR E 2 80  ? 19.979  -36.573 53.035  1.00 21.72  ? 78  THR I O   1 
ATOM   5404 C  CB  . THR E 2 80  ? 22.243  -36.090 55.427  1.00 26.12  ? 78  THR I CB  1 
ATOM   5405 O  OG1 . THR E 2 80  ? 21.051  -36.406 56.154  1.00 24.97  ? 78  THR I OG1 1 
ATOM   5406 C  CG2 . THR E 2 80  ? 23.109  -35.136 56.264  1.00 22.97  ? 78  THR I CG2 1 
ATOM   5407 N  N   . LEU E 2 81  ? 22.034  -37.402 52.605  1.00 16.30  ? 79  LEU I N   1 
ATOM   5408 C  CA  . LEU E 2 81  ? 21.596  -38.658 51.999  1.00 19.81  ? 79  LEU I CA  1 
ATOM   5409 C  C   . LEU E 2 81  ? 22.351  -39.782 52.686  1.00 20.50  ? 79  LEU I C   1 
ATOM   5410 O  O   . LEU E 2 81  ? 23.572  -39.900 52.532  1.00 22.38  ? 79  LEU I O   1 
ATOM   5411 C  CB  . LEU E 2 81  ? 21.916  -38.694 50.501  1.00 19.03  ? 79  LEU I CB  1 
ATOM   5412 C  CG  . LEU E 2 81  ? 21.680  -40.026 49.773  1.00 20.82  ? 79  LEU I CG  1 
ATOM   5413 C  CD1 . LEU E 2 81  ? 20.173  -40.390 49.744  1.00 15.67  ? 79  LEU I CD1 1 
ATOM   5414 C  CD2 . LEU E 2 81  ? 22.251  -40.010 48.341  1.00 17.79  ? 79  LEU I CD2 1 
ATOM   5415 N  N   . GLN E 2 82  ? 21.647  -40.599 53.457  1.00 15.38  ? 80  GLN I N   1 
ATOM   5416 C  CA  . GLN E 2 82  ? 22.275  -41.758 54.088  1.00 20.94  ? 80  GLN I CA  1 
ATOM   5417 C  C   . GLN E 2 82  ? 22.047  -43.018 53.238  1.00 18.74  ? 80  GLN I C   1 
ATOM   5418 O  O   . GLN E 2 82  ? 20.909  -43.357 52.904  1.00 18.78  ? 80  GLN I O   1 
ATOM   5419 C  CB  . GLN E 2 82  ? 21.744  -41.941 55.521  1.00 20.33  ? 80  GLN I CB  1 
ATOM   5420 C  CG  . GLN E 2 82  ? 22.141  -43.262 56.171  1.00 23.84  ? 80  GLN I CG  1 
ATOM   5421 C  CD  . GLN E 2 82  ? 21.381  -43.548 57.471  1.00 28.50  ? 80  GLN I CD  1 
ATOM   5422 O  OE1 . GLN E 2 82  ? 20.578  -44.487 57.543  1.00 32.07  ? 80  GLN I OE1 1 
ATOM   5423 N  NE2 . GLN E 2 82  ? 21.648  -42.757 58.502  1.00 17.04  ? 80  GLN I NE2 1 
ATOM   5424 N  N   . MET E 2 83  ? 23.130  -43.701 52.876  1.00 13.04  ? 81  MET I N   1 
ATOM   5425 C  CA  . MET E 2 83  ? 23.035  -44.916 52.061  1.00 21.43  ? 81  MET I CA  1 
ATOM   5426 C  C   . MET E 2 83  ? 23.515  -46.142 52.824  1.00 19.28  ? 81  MET I C   1 
ATOM   5427 O  O   . MET E 2 83  ? 24.485  -46.067 53.569  1.00 21.77  ? 81  MET I O   1 
ATOM   5428 C  CB  . MET E 2 83  ? 23.857  -44.771 50.771  1.00 20.87  ? 81  MET I CB  1 
ATOM   5429 C  CG  . MET E 2 83  ? 23.395  -43.645 49.856  1.00 24.10  ? 81  MET I CG  1 
ATOM   5430 S  SD  . MET E 2 83  ? 24.314  -43.582 48.287  1.00 29.77  ? 81  MET I SD  1 
ATOM   5431 C  CE  . MET E 2 83  ? 25.867  -42.940 48.888  1.00 16.03  ? 81  MET I CE  1 
ATOM   5432 N  N   . THR E 2 84  ? 22.844  -47.275 52.627  1.00 21.59  ? 82  THR I N   1 
ATOM   5433 C  CA  . THR E 2 84  ? 23.241  -48.520 53.288  1.00 21.33  ? 82  THR I CA  1 
ATOM   5434 C  C   . THR E 2 84  ? 23.369  -49.663 52.272  1.00 25.05  ? 82  THR I C   1 
ATOM   5435 O  O   . THR E 2 84  ? 22.869  -49.569 51.139  1.00 19.08  ? 82  THR I O   1 
ATOM   5436 C  CB  . THR E 2 84  ? 22.214  -48.928 54.388  1.00 21.43  ? 82  THR I CB  1 
ATOM   5437 O  OG1 . THR E 2 84  ? 20.966  -49.231 53.765  1.00 20.48  ? 82  THR I OG1 1 
ATOM   5438 C  CG2 . THR E 2 84  ? 21.997  -47.795 55.373  1.00 23.23  ? 82  THR I CG2 1 
ATOM   5439 N  N   . SER E 2 85  A 24.049  -50.731 52.683  1.00 20.72  ? 82  SER I N   1 
ATOM   5440 C  CA  . SER E 2 85  A 24.219  -51.935 51.851  1.00 23.65  ? 82  SER I CA  1 
ATOM   5441 C  C   . SER E 2 85  A 24.716  -51.639 50.444  1.00 22.74  ? 82  SER I C   1 
ATOM   5442 O  O   . SER E 2 85  A 24.170  -52.158 49.459  1.00 22.84  ? 82  SER I O   1 
ATOM   5443 C  CB  . SER E 2 85  A 22.910  -52.743 51.789  1.00 24.47  ? 82  SER I CB  1 
ATOM   5444 O  OG  . SER E 2 85  A 22.483  -53.101 53.096  1.00 27.06  ? 82  SER I OG  1 
ATOM   5445 N  N   . LEU E 2 86  B 25.772  -50.831 50.346  1.00 24.22  ? 82  LEU I N   1 
ATOM   5446 C  CA  . LEU E 2 86  B 26.242  -50.368 49.043  1.00 23.03  ? 82  LEU I CA  1 
ATOM   5447 C  C   . LEU E 2 86  B 26.827  -51.498 48.204  1.00 26.46  ? 82  LEU I C   1 
ATOM   5448 O  O   . LEU E 2 86  B 27.521  -52.370 48.730  1.00 26.44  ? 82  LEU I O   1 
ATOM   5449 C  CB  . LEU E 2 86  B 27.260  -49.240 49.211  1.00 19.23  ? 82  LEU I CB  1 
ATOM   5450 C  CG  . LEU E 2 86  B 26.658  -47.954 49.767  1.00 24.08  ? 82  LEU I CG  1 
ATOM   5451 C  CD1 . LEU E 2 86  B 27.752  -46.983 50.149  1.00 22.78  ? 82  LEU I CD1 1 
ATOM   5452 C  CD2 . LEU E 2 86  B 25.717  -47.329 48.722  1.00 23.34  ? 82  LEU I CD2 1 
ATOM   5453 N  N   . THR E 2 87  ? 26.516  -51.497 46.908  1.00 20.32  ? 83  THR I N   1 
ATOM   5454 C  CA  . THR E 2 87  ? 27.197  -52.376 45.959  1.00 20.85  ? 83  THR I CA  1 
ATOM   5455 C  C   . THR E 2 87  ? 27.760  -51.594 44.770  1.00 27.00  ? 83  THR I C   1 
ATOM   5456 O  O   . THR E 2 87  ? 27.585  -50.365 44.673  1.00 19.23  ? 83  THR I O   1 
ATOM   5457 C  CB  . THR E 2 87  ? 26.287  -53.508 45.424  1.00 22.68  ? 83  THR I CB  1 
ATOM   5458 O  OG1 . THR E 2 87  ? 25.418  -53.000 44.415  1.00 24.66  ? 83  THR I OG1 1 
ATOM   5459 C  CG2 . THR E 2 87  ? 25.484  -54.162 46.545  1.00 23.32  ? 83  THR I CG2 1 
ATOM   5460 N  N   . ALA E 2 88  ? 28.417  -52.311 43.857  1.00 22.71  ? 84  ALA I N   1 
ATOM   5461 C  CA  . ALA E 2 88  ? 29.001  -51.685 42.669  1.00 26.87  ? 84  ALA I CA  1 
ATOM   5462 C  C   . ALA E 2 88  ? 27.945  -50.959 41.834  1.00 27.55  ? 84  ALA I C   1 
ATOM   5463 O  O   . ALA E 2 88  ? 28.255  -50.001 41.125  1.00 22.55  ? 84  ALA I O   1 
ATOM   5464 C  CB  . ALA E 2 88  ? 29.732  -52.727 41.814  1.00 28.14  ? 84  ALA I CB  1 
ATOM   5465 N  N   . ALA E 2 89  ? 26.691  -51.400 41.940  1.00 20.88  ? 85  ALA I N   1 
ATOM   5466 C  CA  . ALA E 2 89  ? 25.596  -50.766 41.217  1.00 21.01  ? 85  ALA I CA  1 
ATOM   5467 C  C   . ALA E 2 89  ? 25.346  -49.337 41.729  1.00 24.56  ? 85  ALA I C   1 
ATOM   5468 O  O   . ALA E 2 89  ? 24.649  -48.546 41.079  1.00 20.83  ? 85  ALA I O   1 
ATOM   5469 C  CB  . ALA E 2 89  ? 24.323  -51.608 41.327  1.00 25.82  ? 85  ALA I CB  1 
ATOM   5470 N  N   . ASP E 2 90  ? 25.922  -49.009 42.882  1.00 14.16  ? 86  ASP I N   1 
ATOM   5471 C  CA  . ASP E 2 90  ? 25.765  -47.672 43.468  1.00 19.60  ? 86  ASP I CA  1 
ATOM   5472 C  C   . ASP E 2 90  ? 26.923  -46.696 43.199  1.00 20.32  ? 86  ASP I C   1 
ATOM   5473 O  O   . ASP E 2 90  ? 26.891  -45.536 43.646  1.00 19.79  ? 86  ASP I O   1 
ATOM   5474 C  CB  . ASP E 2 90  ? 25.509  -47.782 44.965  1.00 14.59  ? 86  ASP I CB  1 
ATOM   5475 C  CG  . ASP E 2 90  ? 24.281  -48.623 45.284  1.00 19.09  ? 86  ASP I CG  1 
ATOM   5476 O  OD1 . ASP E 2 90  ? 24.409  -49.585 46.073  1.00 22.20  ? 86  ASP I OD1 1 
ATOM   5477 O  OD2 . ASP E 2 90  ? 23.191  -48.336 44.739  1.00 19.81  ? 86  ASP I OD2 1 
ATOM   5478 N  N   . THR E 2 91  ? 27.948  -47.162 42.490  1.00 18.07  ? 87  THR I N   1 
ATOM   5479 C  CA  . THR E 2 91  ? 29.057  -46.306 42.100  1.00 19.16  ? 87  THR I CA  1 
ATOM   5480 C  C   . THR E 2 91  ? 28.543  -45.212 41.173  1.00 19.64  ? 87  THR I C   1 
ATOM   5481 O  O   . THR E 2 91  ? 27.930  -45.515 40.153  1.00 19.95  ? 87  THR I O   1 
ATOM   5482 C  CB  . THR E 2 91  ? 30.170  -47.134 41.393  1.00 26.16  ? 87  THR I CB  1 
ATOM   5483 O  OG1 . THR E 2 91  ? 30.848  -47.944 42.366  1.00 22.09  ? 87  THR I OG1 1 
ATOM   5484 C  CG2 . THR E 2 91  ? 31.185  -46.217 40.703  1.00 22.86  ? 87  THR I CG2 1 
ATOM   5485 N  N   . ALA E 2 92  ? 28.783  -43.950 41.534  1.00 20.36  ? 88  ALA I N   1 
ATOM   5486 C  CA  . ALA E 2 92  ? 28.298  -42.809 40.739  1.00 18.95  ? 88  ALA I CA  1 
ATOM   5487 C  C   . ALA E 2 92  ? 28.747  -41.471 41.304  1.00 19.52  ? 88  ALA I C   1 
ATOM   5488 O  O   . ALA E 2 92  ? 29.257  -41.401 42.425  1.00 20.47  ? 88  ALA I O   1 
ATOM   5489 C  CB  . ALA E 2 92  ? 26.739  -42.827 40.671  1.00 15.62  ? 88  ALA I CB  1 
ATOM   5490 N  N   . THR E 2 93  ? 28.532  -40.403 40.527  1.00 17.49  ? 89  THR I N   1 
ATOM   5491 C  CA  . THR E 2 93  ? 28.507  -39.048 41.077  1.00 14.53  ? 89  THR I CA  1 
ATOM   5492 C  C   . THR E 2 93  ? 27.111  -38.739 41.627  1.00 16.11  ? 89  THR I C   1 
ATOM   5493 O  O   . THR E 2 93  ? 26.100  -39.005 40.962  1.00 17.91  ? 89  THR I O   1 
ATOM   5494 C  CB  . THR E 2 93  ? 28.862  -38.010 39.996  1.00 18.62  ? 89  THR I CB  1 
ATOM   5495 O  OG1 . THR E 2 93  ? 30.170  -38.286 39.512  1.00 21.01  ? 89  THR I OG1 1 
ATOM   5496 C  CG2 . THR E 2 93  ? 28.821  -36.565 40.569  1.00 16.84  ? 89  THR I CG2 1 
ATOM   5497 N  N   . TYR E 2 94  ? 27.059  -38.186 42.838  1.00 14.91  ? 90  TYR I N   1 
ATOM   5498 C  CA  . TYR E 2 94  ? 25.801  -37.833 43.492  1.00 17.77  ? 90  TYR I CA  1 
ATOM   5499 C  C   . TYR E 2 94  ? 25.622  -36.314 43.553  1.00 17.58  ? 90  TYR I C   1 
ATOM   5500 O  O   . TYR E 2 94  ? 26.446  -35.615 44.139  1.00 18.26  ? 90  TYR I O   1 
ATOM   5501 C  CB  . TYR E 2 94  ? 25.752  -38.426 44.909  1.00 14.47  ? 90  TYR I CB  1 
ATOM   5502 C  CG  . TYR E 2 94  ? 25.531  -39.937 44.905  1.00 16.59  ? 90  TYR I CG  1 
ATOM   5503 C  CD1 . TYR E 2 94  ? 24.317  -40.479 45.300  1.00 15.00  ? 90  TYR I CD1 1 
ATOM   5504 C  CD2 . TYR E 2 94  ? 26.529  -40.807 44.467  1.00 18.03  ? 90  TYR I CD2 1 
ATOM   5505 C  CE1 . TYR E 2 94  ? 24.098  -41.862 45.267  1.00 17.67  ? 90  TYR I CE1 1 
ATOM   5506 C  CE2 . TYR E 2 94  ? 26.322  -42.192 44.420  1.00 17.17  ? 90  TYR I CE2 1 
ATOM   5507 C  CZ  . TYR E 2 94  ? 25.104  -42.710 44.826  1.00 17.54  ? 90  TYR I CZ  1 
ATOM   5508 O  OH  . TYR E 2 94  ? 24.896  -44.077 44.788  1.00 17.69  ? 90  TYR I OH  1 
ATOM   5509 N  N   . PHE E 2 95  ? 24.535  -35.820 42.967  1.00 17.78  ? 91  PHE I N   1 
ATOM   5510 C  CA  . PHE E 2 95  ? 24.220  -34.382 42.962  1.00 17.18  ? 91  PHE I CA  1 
ATOM   5511 C  C   . PHE E 2 95  ? 23.076  -34.103 43.911  1.00 19.44  ? 91  PHE I C   1 
ATOM   5512 O  O   . PHE E 2 95  ? 22.198  -34.950 44.066  1.00 17.37  ? 91  PHE I O   1 
ATOM   5513 C  CB  . PHE E 2 95  ? 23.737  -33.942 41.577  1.00 13.14  ? 91  PHE I CB  1 
ATOM   5514 C  CG  . PHE E 2 95  ? 24.746  -34.114 40.478  1.00 15.44  ? 91  PHE I CG  1 
ATOM   5515 C  CD1 . PHE E 2 95  ? 25.726  -33.156 40.264  1.00 20.84  ? 91  PHE I CD1 1 
ATOM   5516 C  CD2 . PHE E 2 95  ? 24.686  -35.213 39.628  1.00 16.24  ? 91  PHE I CD2 1 
ATOM   5517 C  CE1 . PHE E 2 95  ? 26.653  -33.298 39.228  1.00 16.92  ? 91  PHE I CE1 1 
ATOM   5518 C  CE2 . PHE E 2 95  ? 25.605  -35.360 38.589  1.00 18.96  ? 91  PHE I CE2 1 
ATOM   5519 C  CZ  . PHE E 2 95  ? 26.588  -34.404 38.388  1.00 16.03  ? 91  PHE I CZ  1 
ATOM   5520 N  N   . CYS E 2 96  ? 23.052  -32.917 44.524  1.00 16.21  ? 92  CYS I N   1 
ATOM   5521 C  CA  . CYS E 2 96  ? 21.821  -32.446 45.147  1.00 14.50  ? 92  CYS I CA  1 
ATOM   5522 C  C   . CYS E 2 96  ? 21.315  -31.218 44.410  1.00 16.83  ? 92  CYS I C   1 
ATOM   5523 O  O   . CYS E 2 96  ? 22.089  -30.507 43.779  1.00 19.26  ? 92  CYS I O   1 
ATOM   5524 C  CB  . CYS E 2 96  ? 21.992  -32.165 46.644  1.00 21.07  ? 92  CYS I CB  1 
ATOM   5525 S  SG  . CYS E 2 96  ? 22.968  -30.698 47.078  1.00 33.76  ? 92  CYS I SG  1 
ATOM   5526 N  N   . ALA E 2 97  ? 20.011  -30.975 44.461  1.00 15.83  ? 93  ALA I N   1 
ATOM   5527 C  CA  . ALA E 2 97  ? 19.449  -29.849 43.720  1.00 20.67  ? 93  ALA I CA  1 
ATOM   5528 C  C   . ALA E 2 97  ? 18.285  -29.207 44.474  1.00 19.36  ? 93  ALA I C   1 
ATOM   5529 O  O   . ALA E 2 97  ? 17.578  -29.871 45.221  1.00 18.40  ? 93  ALA I O   1 
ATOM   5530 C  CB  . ALA E 2 97  ? 19.003  -30.293 42.320  1.00 18.55  ? 93  ALA I CB  1 
ATOM   5531 N  N   . ARG E 2 98  ? 18.105  -27.908 44.275  1.00 14.62  ? 94  ARG I N   1 
ATOM   5532 C  CA  . ARG E 2 98  ? 16.945  -27.198 44.793  1.00 16.69  ? 94  ARG I CA  1 
ATOM   5533 C  C   . ARG E 2 98  ? 15.919  -26.991 43.668  1.00 16.03  ? 94  ARG I C   1 
ATOM   5534 O  O   . ARG E 2 98  ? 16.185  -26.235 42.719  1.00 17.13  ? 94  ARG I O   1 
ATOM   5535 C  CB  . ARG E 2 98  ? 17.390  -25.823 45.323  1.00 16.18  ? 94  ARG I CB  1 
ATOM   5536 C  CG  . ARG E 2 98  ? 16.296  -25.044 46.027  1.00 20.59  ? 94  ARG I CG  1 
ATOM   5537 C  CD  . ARG E 2 98  ? 16.810  -23.675 46.482  1.00 23.25  ? 94  ARG I CD  1 
ATOM   5538 N  NE  . ARG E 2 98  ? 16.749  -22.689 45.405  1.00 21.53  ? 94  ARG I NE  1 
ATOM   5539 C  CZ  . ARG E 2 98  ? 17.155  -21.424 45.518  1.00 39.27  ? 94  ARG I CZ  1 
ATOM   5540 N  NH1 . ARG E 2 98  ? 17.059  -20.601 44.480  1.00 30.75  ? 94  ARG I NH1 1 
ATOM   5541 N  NH2 . ARG E 2 98  ? 17.652  -20.976 46.667  1.00 33.42  ? 94  ARG I NH2 1 
ATOM   5542 N  N   . ASN E 2 99  ? 14.744  -27.604 43.788  1.00 18.39  ? 95  ASN I N   1 
ATOM   5543 C  CA  . ASN E 2 99  ? 13.706  -27.506 42.750  1.00 20.07  ? 95  ASN I CA  1 
ATOM   5544 C  C   . ASN E 2 99  ? 14.260  -27.849 41.349  1.00 22.69  ? 95  ASN I C   1 
ATOM   5545 O  O   . ASN E 2 99  ? 13.819  -27.278 40.346  1.00 24.28  ? 95  ASN I O   1 
ATOM   5546 C  CB  . ASN E 2 99  ? 13.095  -26.088 42.699  1.00 21.47  ? 95  ASN I CB  1 
ATOM   5547 C  CG  . ASN E 2 99  ? 12.294  -25.715 43.965  1.00 28.06  ? 95  ASN I CG  1 
ATOM   5548 O  OD1 . ASN E 2 99  ? 12.019  -26.546 44.823  1.00 25.93  ? 95  ASN I OD1 1 
ATOM   5549 N  ND2 . ASN E 2 99  ? 11.909  -24.448 44.056  1.00 25.14  ? 95  ASN I ND2 1 
ATOM   5550 N  N   . PHE E 2 100 ? 15.257  -28.732 41.295  1.00 18.38  ? 96  PHE I N   1 
ATOM   5551 C  CA  . PHE E 2 100 ? 15.912  -29.135 40.031  1.00 19.18  ? 96  PHE I CA  1 
ATOM   5552 C  C   . PHE E 2 100 ? 16.458  -27.951 39.205  1.00 24.79  ? 96  PHE I C   1 
ATOM   5553 O  O   . PHE E 2 100 ? 16.632  -28.047 37.991  1.00 17.48  ? 96  PHE I O   1 
ATOM   5554 C  CB  . PHE E 2 100 ? 14.971  -30.006 39.191  1.00 16.89  ? 96  PHE I CB  1 
ATOM   5555 C  CG  . PHE E 2 100 ? 14.650  -31.334 39.836  1.00 15.64  ? 96  PHE I CG  1 
ATOM   5556 C  CD1 . PHE E 2 100 ? 13.493  -31.490 40.604  1.00 18.60  ? 96  PHE I CD1 1 
ATOM   5557 C  CD2 . PHE E 2 100 ? 15.516  -32.405 39.709  1.00 17.89  ? 96  PHE I CD2 1 
ATOM   5558 C  CE1 . PHE E 2 100 ? 13.195  -32.695 41.214  1.00 18.25  ? 96  PHE I CE1 1 
ATOM   5559 C  CE2 . PHE E 2 100 ? 15.227  -33.630 40.317  1.00 15.99  ? 96  PHE I CE2 1 
ATOM   5560 C  CZ  . PHE E 2 100 ? 14.064  -33.774 41.065  1.00 18.30  ? 96  PHE I CZ  1 
ATOM   5561 N  N   . ASP E 2 101 ? 16.757  -26.859 39.898  1.00 19.10  ? 101 ASP I N   1 
ATOM   5562 C  CA  . ASP E 2 101 ? 17.048  -25.556 39.290  1.00 18.72  ? 101 ASP I CA  1 
ATOM   5563 C  C   . ASP E 2 101 ? 18.474  -25.137 39.692  1.00 24.70  ? 101 ASP I C   1 
ATOM   5564 O  O   . ASP E 2 101 ? 19.342  -24.940 38.841  1.00 26.22  ? 101 ASP I O   1 
ATOM   5565 C  CB  . ASP E 2 101 ? 15.982  -24.561 39.771  1.00 21.70  ? 101 ASP I CB  1 
ATOM   5566 C  CG  . ASP E 2 101 ? 16.239  -23.127 39.330  1.00 36.12  ? 101 ASP I CG  1 
ATOM   5567 O  OD1 . ASP E 2 101 ? 16.995  -22.879 38.366  1.00 25.53  ? 101 ASP I OD1 1 
ATOM   5568 O  OD2 . ASP E 2 101 ? 15.652  -22.232 39.968  1.00 43.28  ? 101 ASP I OD2 1 
ATOM   5569 N  N   . LEU E 2 102 ? 18.725  -25.049 40.992  1.00 23.54  ? 102 LEU I N   1 
ATOM   5570 C  CA  . LEU E 2 102 ? 20.075  -24.856 41.515  1.00 22.91  ? 102 LEU I CA  1 
ATOM   5571 C  C   . LEU E 2 102 ? 20.721  -26.229 41.749  1.00 23.32  ? 102 LEU I C   1 
ATOM   5572 O  O   . LEU E 2 102 ? 20.127  -27.069 42.424  1.00 20.31  ? 102 LEU I O   1 
ATOM   5573 C  CB  . LEU E 2 102 ? 19.974  -24.119 42.858  1.00 23.46  ? 102 LEU I CB  1 
ATOM   5574 C  CG  . LEU E 2 102 ? 20.887  -22.954 43.211  1.00 35.54  ? 102 LEU I CG  1 
ATOM   5575 C  CD1 . LEU E 2 102 ? 20.990  -22.783 44.736  1.00 26.51  ? 102 LEU I CD1 1 
ATOM   5576 C  CD2 . LEU E 2 102 ? 22.274  -23.087 42.577  1.00 34.64  ? 102 LEU I CD2 1 
ATOM   5577 N  N   . TRP E 2 103 ? 21.920  -26.465 41.209  1.00 17.96  ? 103 TRP I N   1 
ATOM   5578 C  CA  . TRP E 2 103 ? 22.618  -27.751 41.392  1.00 21.01  ? 103 TRP I CA  1 
ATOM   5579 C  C   . TRP E 2 103 ? 24.022  -27.588 41.996  1.00 23.63  ? 103 TRP I C   1 
ATOM   5580 O  O   . TRP E 2 103 ? 24.704  -26.600 41.744  1.00 19.15  ? 103 TRP I O   1 
ATOM   5581 C  CB  . TRP E 2 103 ? 22.778  -28.503 40.055  1.00 21.53  ? 103 TRP I CB  1 
ATOM   5582 C  CG  . TRP E 2 103 ? 21.508  -28.934 39.366  1.00 19.22  ? 103 TRP I CG  1 
ATOM   5583 C  CD1 . TRP E 2 103 ? 20.587  -28.126 38.754  1.00 21.28  ? 103 TRP I CD1 1 
ATOM   5584 C  CD2 . TRP E 2 103 ? 21.038  -30.276 39.199  1.00 16.55  ? 103 TRP I CD2 1 
ATOM   5585 N  NE1 . TRP E 2 103 ? 19.568  -28.885 38.229  1.00 17.00  ? 103 TRP I NE1 1 
ATOM   5586 C  CE2 . TRP E 2 103 ? 19.819  -30.206 38.488  1.00 17.29  ? 103 TRP I CE2 1 
ATOM   5587 C  CE3 . TRP E 2 103 ? 21.519  -31.531 39.589  1.00 18.29  ? 103 TRP I CE3 1 
ATOM   5588 C  CZ2 . TRP E 2 103 ? 19.080  -31.344 38.155  1.00 18.97  ? 103 TRP I CZ2 1 
ATOM   5589 C  CZ3 . TRP E 2 103 ? 20.792  -32.666 39.241  1.00 19.71  ? 103 TRP I CZ3 1 
ATOM   5590 C  CH2 . TRP E 2 103 ? 19.584  -32.563 38.538  1.00 18.93  ? 103 TRP I CH2 1 
ATOM   5591 N  N   . GLY E 2 104 ? 24.455  -28.578 42.772  1.00 18.05  ? 104 GLY I N   1 
ATOM   5592 C  CA  . GLY E 2 104 ? 25.831  -28.642 43.226  1.00 16.28  ? 104 GLY I CA  1 
ATOM   5593 C  C   . GLY E 2 104 ? 26.729  -29.264 42.163  1.00 17.56  ? 104 GLY I C   1 
ATOM   5594 O  O   . GLY E 2 104 ? 26.247  -29.797 41.164  1.00 18.33  ? 104 GLY I O   1 
ATOM   5595 N  N   . PRO E 2 105 ? 28.049  -29.209 42.373  1.00 19.23  ? 105 PRO I N   1 
ATOM   5596 C  CA  . PRO E 2 105 ? 28.977  -29.754 41.379  1.00 22.93  ? 105 PRO I CA  1 
ATOM   5597 C  C   . PRO E 2 105 ? 29.084  -31.275 41.462  1.00 24.29  ? 105 PRO I C   1 
ATOM   5598 O  O   . PRO E 2 105 ? 29.669  -31.875 40.572  1.00 19.60  ? 105 PRO I O   1 
ATOM   5599 C  CB  . PRO E 2 105 ? 30.317  -29.113 41.756  1.00 23.15  ? 105 PRO I CB  1 
ATOM   5600 C  CG  . PRO E 2 105 ? 30.196  -28.824 43.212  1.00 27.03  ? 105 PRO I CG  1 
ATOM   5601 C  CD  . PRO E 2 105 ? 28.750  -28.486 43.450  1.00 23.61  ? 105 PRO I CD  1 
ATOM   5602 N  N   . GLY E 2 106 ? 28.534  -31.885 42.509  1.00 19.75  ? 106 GLY I N   1 
ATOM   5603 C  CA  . GLY E 2 106 ? 28.527  -33.337 42.609  1.00 20.96  ? 106 GLY I CA  1 
ATOM   5604 C  C   . GLY E 2 106 ? 29.636  -33.882 43.501  1.00 26.74  ? 106 GLY I C   1 
ATOM   5605 O  O   . GLY E 2 106 ? 30.664  -33.236 43.677  1.00 23.35  ? 106 GLY I O   1 
ATOM   5606 N  N   . THR E 2 107 ? 29.424  -35.059 44.084  1.00 21.69  ? 107 THR I N   1 
ATOM   5607 C  CA  . THR E 2 107 ? 30.473  -35.719 44.876  1.00 22.58  ? 107 THR I CA  1 
ATOM   5608 C  C   . THR E 2 107 ? 30.498  -37.189 44.478  1.00 25.22  ? 107 THR I C   1 
ATOM   5609 O  O   . THR E 2 107 ? 29.443  -37.813 44.266  1.00 19.56  ? 107 THR I O   1 
ATOM   5610 C  CB  . THR E 2 107 ? 30.283  -35.505 46.415  1.00 26.23  ? 107 THR I CB  1 
ATOM   5611 O  OG1 . THR E 2 107 ? 31.432  -35.974 47.149  1.00 21.83  ? 107 THR I OG1 1 
ATOM   5612 C  CG2 . THR E 2 107 ? 29.036  -36.197 46.929  1.00 16.50  ? 107 THR I CG2 1 
ATOM   5613 N  N   . LEU E 2 108 ? 31.699  -37.734 44.333  1.00 18.44  ? 108 LEU I N   1 
ATOM   5614 C  CA  . LEU E 2 108 ? 31.868  -39.062 43.730  1.00 20.92  ? 108 LEU I CA  1 
ATOM   5615 C  C   . LEU E 2 108 ? 31.883  -40.197 44.762  1.00 25.38  ? 108 LEU I C   1 
ATOM   5616 O  O   . LEU E 2 108 ? 32.602  -40.134 45.759  1.00 27.08  ? 108 LEU I O   1 
ATOM   5617 C  CB  . LEU E 2 108 ? 33.154  -39.095 42.899  1.00 22.30  ? 108 LEU I CB  1 
ATOM   5618 C  CG  . LEU E 2 108 ? 33.501  -40.414 42.206  1.00 25.63  ? 108 LEU I CG  1 
ATOM   5619 C  CD1 . LEU E 2 108 ? 32.472  -40.768 41.134  1.00 22.70  ? 108 LEU I CD1 1 
ATOM   5620 C  CD2 . LEU E 2 108 ? 34.894  -40.368 41.611  1.00 34.06  ? 108 LEU I CD2 1 
ATOM   5621 N  N   . VAL E 2 109 ? 31.110  -41.249 44.510  1.00 26.00  ? 109 VAL I N   1 
ATOM   5622 C  CA  . VAL E 2 109 ? 31.122  -42.425 45.380  1.00 20.66  ? 109 VAL I CA  1 
ATOM   5623 C  C   . VAL E 2 109 ? 31.578  -43.638 44.580  1.00 23.25  ? 109 VAL I C   1 
ATOM   5624 O  O   . VAL E 2 109 ? 31.052  -43.905 43.502  1.00 23.79  ? 109 VAL I O   1 
ATOM   5625 C  CB  . VAL E 2 109 ? 29.735  -42.716 45.983  1.00 21.15  ? 109 VAL I CB  1 
ATOM   5626 C  CG1 . VAL E 2 109 ? 29.745  -44.061 46.692  1.00 22.99  ? 109 VAL I CG1 1 
ATOM   5627 C  CG2 . VAL E 2 109 ? 29.320  -41.614 46.949  1.00 18.77  ? 109 VAL I CG2 1 
ATOM   5628 N  N   . ILE E 2 110 ? 32.586  -44.350 45.083  1.00 26.14  ? 110 ILE I N   1 
ATOM   5629 C  CA  . ILE E 2 110 ? 33.089  -45.544 44.411  1.00 21.74  ? 110 ILE I CA  1 
ATOM   5630 C  C   . ILE E 2 110 ? 32.951  -46.733 45.355  1.00 24.71  ? 110 ILE I C   1 
ATOM   5631 O  O   . ILE E 2 110 ? 33.499  -46.713 46.456  1.00 25.89  ? 110 ILE I O   1 
ATOM   5632 C  CB  . ILE E 2 110 ? 34.584  -45.420 44.043  1.00 28.46  ? 110 ILE I CB  1 
ATOM   5633 C  CG1 . ILE E 2 110 ? 34.882  -44.064 43.388  1.00 29.56  ? 110 ILE I CG1 1 
ATOM   5634 C  CG2 . ILE E 2 110 ? 34.984  -46.548 43.116  1.00 22.24  ? 110 ILE I CG2 1 
ATOM   5635 C  CD1 . ILE E 2 110 ? 34.341  -43.964 41.988  1.00 32.92  ? 110 ILE I CD1 1 
ATOM   5636 N  N   . VAL E 2 111 ? 32.228  -47.766 44.935  1.00 27.12  ? 111 VAL I N   1 
ATOM   5637 C  CA  . VAL E 2 111 ? 32.061  -48.956 45.780  1.00 25.85  ? 111 VAL I CA  1 
ATOM   5638 C  C   . VAL E 2 111 ? 32.835  -50.124 45.188  1.00 25.55  ? 111 VAL I C   1 
ATOM   5639 O  O   . VAL E 2 111 ? 32.465  -50.658 44.149  1.00 25.17  ? 111 VAL I O   1 
ATOM   5640 C  CB  . VAL E 2 111 ? 30.575  -49.354 45.965  1.00 24.02  ? 111 VAL I CB  1 
ATOM   5641 C  CG1 . VAL E 2 111 ? 30.455  -50.577 46.897  1.00 19.89  ? 111 VAL I CG1 1 
ATOM   5642 C  CG2 . VAL E 2 111 ? 29.766  -48.170 46.520  1.00 19.42  ? 111 VAL I CG2 1 
ATOM   5643 N  N   . SER E 2 112 ? 33.919  -50.506 45.859  1.00 25.76  ? 112 SER I N   1 
ATOM   5644 C  CA  . SER E 2 112 ? 34.847  -51.485 45.314  1.00 32.37  ? 112 SER I CA  1 
ATOM   5645 C  C   . SER E 2 112 ? 35.736  -52.058 46.412  1.00 31.32  ? 112 SER I C   1 
ATOM   5646 O  O   . SER E 2 112 ? 36.040  -51.374 47.396  1.00 31.25  ? 112 SER I O   1 
ATOM   5647 C  CB  . SER E 2 112 ? 35.722  -50.821 44.244  1.00 34.38  ? 112 SER I CB  1 
ATOM   5648 O  OG  . SER E 2 112 ? 36.813  -51.645 43.875  1.00 35.21  ? 112 SER I OG  1 
ATOM   5649 N  N   . SER E 2 113 ? 36.160  -53.306 46.234  1.00 32.09  ? 113 SER I N   1 
ATOM   5650 C  CA  . SER E 2 113 ? 37.097  -53.934 47.172  1.00 41.67  ? 113 SER I CA  1 
ATOM   5651 C  C   . SER E 2 113 ? 38.548  -53.708 46.740  1.00 40.87  ? 113 SER I C   1 
ATOM   5652 O  O   . SER E 2 113 ? 39.495  -54.148 47.396  1.00 44.25  ? 113 SER I O   1 
ATOM   5653 C  CB  . SER E 2 113 ? 36.800  -55.427 47.322  1.00 35.11  ? 113 SER I CB  1 
ATOM   5654 O  OG  . SER E 2 113 ? 36.696  -56.045 46.053  1.00 40.41  ? 113 SER I OG  1 
ATOM   5655 N  N   . GLY E 2 114 ? 38.717  -53.007 45.633  1.00 34.52  ? 114 GLY I N   1 
ATOM   5656 C  CA  . GLY E 2 114 ? 40.040  -52.584 45.226  1.00 36.00  ? 114 GLY I CA  1 
ATOM   5657 C  C   . GLY E 2 114 ? 40.639  -51.677 46.277  1.00 37.96  ? 114 GLY I C   1 
ATOM   5658 O  O   . GLY E 2 114 ? 39.949  -50.967 47.008  1.00 35.50  ? 114 GLY I O   1 
ATOM   5659 N  N   . GLN E 2 115 ? 41.952  -51.703 46.364  1.00 42.22  ? 115 GLN I N   1 
ATOM   5660 C  CA  . GLN E 2 115 ? 42.645  -50.826 47.285  1.00 37.54  ? 115 GLN I CA  1 
ATOM   5661 C  C   . GLN E 2 115 ? 43.241  -49.650 46.513  1.00 32.10  ? 115 GLN I C   1 
ATOM   5662 O  O   . GLN E 2 115 ? 43.681  -49.817 45.379  1.00 35.55  ? 115 GLN I O   1 
ATOM   5663 C  CB  . GLN E 2 115 ? 43.708  -51.617 48.046  1.00 47.06  ? 115 GLN I CB  1 
ATOM   5664 C  CG  . GLN E 2 115 ? 43.112  -52.752 48.912  1.00 53.00  ? 115 GLN I CG  1 
ATOM   5665 C  CD  . GLN E 2 115 ? 42.249  -52.232 50.065  1.00 56.83  ? 115 GLN I CD  1 
ATOM   5666 O  OE1 . GLN E 2 115 ? 42.641  -51.309 50.781  1.00 57.75  ? 115 GLN I OE1 1 
ATOM   5667 N  NE2 . GLN E 2 115 ? 41.068  -52.823 50.241  1.00 62.57  ? 115 GLN I NE2 1 
ATOM   5668 N  N   . PRO E 2 116 ? 43.246  -48.458 47.123  1.00 26.91  ? 116 PRO I N   1 
ATOM   5669 C  CA  . PRO E 2 116 ? 43.703  -47.257 46.424  1.00 28.36  ? 116 PRO I CA  1 
ATOM   5670 C  C   . PRO E 2 116 ? 45.156  -47.392 46.010  1.00 33.01  ? 116 PRO I C   1 
ATOM   5671 O  O   . PRO E 2 116 ? 45.927  -48.060 46.698  1.00 32.82  ? 116 PRO I O   1 
ATOM   5672 C  CB  . PRO E 2 116 ? 43.583  -46.156 47.486  1.00 33.32  ? 116 PRO I CB  1 
ATOM   5673 C  CG  . PRO E 2 116 ? 42.677  -46.705 48.531  1.00 35.40  ? 116 PRO I CG  1 
ATOM   5674 C  CD  . PRO E 2 116 ? 42.902  -48.183 48.527  1.00 31.25  ? 116 PRO I CD  1 
ATOM   5675 N  N   . LYS E 2 117 ? 45.520  -46.760 44.900  1.00 27.13  ? 117 LYS I N   1 
ATOM   5676 C  CA  . LYS E 2 117 ? 46.900  -46.750 44.422  1.00 27.67  ? 117 LYS I CA  1 
ATOM   5677 C  C   . LYS E 2 117 ? 47.253  -45.373 43.847  1.00 31.98  ? 117 LYS I C   1 
ATOM   5678 O  O   . LYS E 2 117 ? 46.540  -44.851 42.980  1.00 28.46  ? 117 LYS I O   1 
ATOM   5679 C  CB  . LYS E 2 117 ? 47.108  -47.854 43.380  1.00 30.76  ? 117 LYS I CB  1 
ATOM   5680 C  CG  . LYS E 2 117 ? 48.523  -47.927 42.830  1.00 40.59  ? 117 LYS I CG  1 
ATOM   5681 C  CD  . LYS E 2 117 ? 48.678  -49.115 41.899  1.00 47.77  ? 117 LYS I CD  1 
ATOM   5682 C  CE  . LYS E 2 117 ? 50.084  -49.190 41.318  1.00 45.16  ? 117 LYS I CE  1 
ATOM   5683 N  NZ  . LYS E 2 117 ? 50.377  -48.041 40.417  1.00 47.58  ? 117 LYS I NZ  1 
ATOM   5684 N  N   . ALA E 2 118 ? 48.338  -44.784 44.345  1.00 24.24  ? 118 ALA I N   1 
ATOM   5685 C  CA  . ALA E 2 118 ? 48.729  -43.432 43.967  1.00 27.98  ? 118 ALA I CA  1 
ATOM   5686 C  C   . ALA E 2 118 ? 49.323  -43.428 42.559  1.00 25.52  ? 118 ALA I C   1 
ATOM   5687 O  O   . ALA E 2 118 ? 49.916  -44.412 42.138  1.00 31.15  ? 118 ALA I O   1 
ATOM   5688 C  CB  . ALA E 2 118 ? 49.728  -42.871 44.982  1.00 30.54  ? 118 ALA I CB  1 
ATOM   5689 N  N   . PRO E 2 119 ? 49.149  -42.323 41.820  1.00 25.31  ? 119 PRO I N   1 
ATOM   5690 C  CA  . PRO E 2 119 ? 49.642  -42.246 40.440  1.00 23.52  ? 119 PRO I CA  1 
ATOM   5691 C  C   . PRO E 2 119 ? 51.164  -42.086 40.358  1.00 20.28  ? 119 PRO I C   1 
ATOM   5692 O  O   . PRO E 2 119 ? 51.778  -41.530 41.262  1.00 22.67  ? 119 PRO I O   1 
ATOM   5693 C  CB  . PRO E 2 119 ? 48.988  -40.970 39.922  1.00 25.29  ? 119 PRO I CB  1 
ATOM   5694 C  CG  . PRO E 2 119 ? 48.880  -40.107 41.127  1.00 25.83  ? 119 PRO I CG  1 
ATOM   5695 C  CD  . PRO E 2 119 ? 48.531  -41.060 42.252  1.00 22.85  ? 119 PRO I CD  1 
ATOM   5696 N  N   . SER E 2 120 ? 51.748  -42.585 39.280  1.00 21.86  ? 120 SER I N   1 
ATOM   5697 C  CA  . SER E 2 120 ? 53.090  -42.211 38.887  1.00 27.58  ? 120 SER I CA  1 
ATOM   5698 C  C   . SER E 2 120 ? 52.979  -41.072 37.871  1.00 29.40  ? 120 SER I C   1 
ATOM   5699 O  O   . SER E 2 120 ? 52.128  -41.104 36.973  1.00 28.22  ? 120 SER I O   1 
ATOM   5700 C  CB  . SER E 2 120 ? 53.809  -43.405 38.269  1.00 28.35  ? 120 SER I CB  1 
ATOM   5701 O  OG  . SER E 2 120 ? 53.957  -44.442 39.225  1.00 38.19  ? 120 SER I OG  1 
ATOM   5702 N  N   . VAL E 2 121 ? 53.822  -40.058 38.019  1.00 26.96  ? 121 VAL I N   1 
ATOM   5703 C  CA  . VAL E 2 121 ? 53.789  -38.903 37.121  1.00 23.91  ? 121 VAL I CA  1 
ATOM   5704 C  C   . VAL E 2 121 ? 55.093  -38.784 36.311  1.00 29.98  ? 121 VAL I C   1 
ATOM   5705 O  O   . VAL E 2 121 ? 56.193  -38.766 36.881  1.00 24.80  ? 121 VAL I O   1 
ATOM   5706 C  CB  . VAL E 2 121 ? 53.539  -37.611 37.903  1.00 26.11  ? 121 VAL I CB  1 
ATOM   5707 C  CG1 . VAL E 2 121 ? 53.410  -36.425 36.942  1.00 27.85  ? 121 VAL I CG1 1 
ATOM   5708 C  CG2 . VAL E 2 121 ? 52.279  -37.745 38.775  1.00 21.22  ? 121 VAL I CG2 1 
ATOM   5709 N  N   . PHE E 2 122 ? 54.972  -38.719 34.985  1.00 23.15  ? 122 PHE I N   1 
ATOM   5710 C  CA  . PHE E 2 122 ? 56.143  -38.607 34.107  1.00 21.84  ? 122 PHE I CA  1 
ATOM   5711 C  C   . PHE E 2 122 ? 56.014  -37.390 33.194  1.00 26.88  ? 122 PHE I C   1 
ATOM   5712 O  O   . PHE E 2 122 ? 54.921  -37.085 32.721  1.00 21.81  ? 122 PHE I O   1 
ATOM   5713 C  CB  . PHE E 2 122 ? 56.291  -39.850 33.242  1.00 20.03  ? 122 PHE I CB  1 
ATOM   5714 C  CG  . PHE E 2 122 ? 56.427  -41.129 34.029  1.00 28.10  ? 122 PHE I CG  1 
ATOM   5715 C  CD1 . PHE E 2 122 ? 57.647  -41.488 34.589  1.00 27.10  ? 122 PHE I CD1 1 
ATOM   5716 C  CD2 . PHE E 2 122 ? 55.337  -41.968 34.207  1.00 24.83  ? 122 PHE I CD2 1 
ATOM   5717 C  CE1 . PHE E 2 122 ? 57.779  -42.658 35.320  1.00 31.83  ? 122 PHE I CE1 1 
ATOM   5718 C  CE2 . PHE E 2 122 ? 55.458  -43.155 34.931  1.00 35.71  ? 122 PHE I CE2 1 
ATOM   5719 C  CZ  . PHE E 2 122 ? 56.685  -43.498 35.489  1.00 32.59  ? 122 PHE I CZ  1 
ATOM   5720 N  N   . PRO E 2 123 ? 57.132  -36.698 32.919  1.00 27.12  ? 123 PRO I N   1 
ATOM   5721 C  CA  . PRO E 2 123 ? 57.059  -35.508 32.062  1.00 28.96  ? 123 PRO I CA  1 
ATOM   5722 C  C   . PRO E 2 123 ? 56.930  -35.855 30.573  1.00 27.57  ? 123 PRO I C   1 
ATOM   5723 O  O   . PRO E 2 123 ? 57.397  -36.907 30.132  1.00 26.34  ? 123 PRO I O   1 
ATOM   5724 C  CB  . PRO E 2 123 ? 58.395  -34.803 32.330  1.00 32.41  ? 123 PRO I CB  1 
ATOM   5725 C  CG  . PRO E 2 123 ? 59.330  -35.911 32.699  1.00 36.48  ? 123 PRO I CG  1 
ATOM   5726 C  CD  . PRO E 2 123 ? 58.486  -36.904 33.468  1.00 30.14  ? 123 PRO I CD  1 
ATOM   5727 N  N   . LEU E 2 124 ? 56.274  -34.977 29.819  1.00 27.37  ? 124 LEU I N   1 
ATOM   5728 C  CA  . LEU E 2 124 ? 56.146  -35.134 28.377  1.00 26.84  ? 124 LEU I CA  1 
ATOM   5729 C  C   . LEU E 2 124 ? 56.799  -33.928 27.715  1.00 29.55  ? 124 LEU I C   1 
ATOM   5730 O  O   . LEU E 2 124 ? 56.450  -32.771 28.016  1.00 24.80  ? 124 LEU I O   1 
ATOM   5731 C  CB  . LEU E 2 124 ? 54.677  -35.212 27.961  1.00 20.73  ? 124 LEU I CB  1 
ATOM   5732 C  CG  . LEU E 2 124 ? 53.797  -36.314 28.557  1.00 25.72  ? 124 LEU I CG  1 
ATOM   5733 C  CD1 . LEU E 2 124 ? 52.340  -36.085 28.162  1.00 20.76  ? 124 LEU I CD1 1 
ATOM   5734 C  CD2 . LEU E 2 124 ? 54.279  -37.689 28.088  1.00 18.88  ? 124 LEU I CD2 1 
ATOM   5735 N  N   . ALA E 2 125 ? 57.751  -34.199 26.828  1.00 23.86  ? 125 ALA I N   1 
ATOM   5736 C  CA  . ALA E 2 125 ? 58.452  -33.150 26.101  1.00 33.12  ? 125 ALA I CA  1 
ATOM   5737 C  C   . ALA E 2 125 ? 58.925  -33.687 24.758  1.00 29.57  ? 125 ALA I C   1 
ATOM   5738 O  O   . ALA E 2 125 ? 59.231  -34.866 24.649  1.00 27.25  ? 125 ALA I O   1 
ATOM   5739 C  CB  . ALA E 2 125 ? 59.631  -32.648 26.914  1.00 30.16  ? 125 ALA I CB  1 
ATOM   5740 N  N   . PRO E 2 126 ? 58.984  -32.821 23.731  1.00 34.42  ? 126 PRO I N   1 
ATOM   5741 C  CA  . PRO E 2 126 ? 59.401  -33.239 22.384  1.00 40.58  ? 126 PRO I CA  1 
ATOM   5742 C  C   . PRO E 2 126 ? 60.773  -33.895 22.389  1.00 42.21  ? 126 PRO I C   1 
ATOM   5743 O  O   . PRO E 2 126 ? 61.574  -33.614 23.273  1.00 38.94  ? 126 PRO I O   1 
ATOM   5744 C  CB  . PRO E 2 126 ? 59.459  -31.917 21.600  1.00 46.31  ? 126 PRO I CB  1 
ATOM   5745 C  CG  . PRO E 2 126 ? 59.496  -30.836 22.650  1.00 47.95  ? 126 PRO I CG  1 
ATOM   5746 C  CD  . PRO E 2 126 ? 58.700  -31.377 23.795  1.00 36.98  ? 126 PRO I CD  1 
ATOM   5747 N  N   . CYS E 2 127 ? 61.031  -34.774 21.430  1.00 42.01  ? 127 CYS I N   1 
ATOM   5748 C  CA  . CYS E 2 127 ? 62.301  -35.488 21.384  1.00 42.93  ? 127 CYS I CA  1 
ATOM   5749 C  C   . CYS E 2 127 ? 63.465  -34.519 21.235  1.00 52.38  ? 127 CYS I C   1 
ATOM   5750 O  O   . CYS E 2 127 ? 63.363  -33.516 20.525  1.00 42.10  ? 127 CYS I O   1 
ATOM   5751 C  CB  . CYS E 2 127 ? 62.316  -36.502 20.245  1.00 41.58  ? 127 CYS I CB  1 
ATOM   5752 S  SG  . CYS E 2 127 ? 63.885  -37.387 20.069  1.00 42.53  ? 127 CYS I SG  1 
ATOM   5753 N  N   . CYS E 2 128 ? 64.556  -34.818 21.930  1.00 50.54  ? 128 CYS I N   1 
ATOM   5754 C  CA  . CYS E 2 128 ? 65.776  -34.011 21.903  1.00 61.71  ? 128 CYS I CA  1 
ATOM   5755 C  C   . CYS E 2 128 ? 66.147  -33.487 20.510  1.00 61.22  ? 128 CYS I C   1 
ATOM   5756 O  O   . CYS E 2 128 ? 66.406  -34.266 19.589  1.00 55.22  ? 128 CYS I O   1 
ATOM   5757 C  CB  . CYS E 2 128 ? 66.937  -34.831 22.493  1.00 61.68  ? 128 CYS I CB  1 
ATOM   5758 S  SG  . CYS E 2 128 ? 68.623  -34.194 22.201  1.00 73.69  ? 128 CYS I SG  1 
ATOM   5759 N  N   . GLY E 2 129 ? 66.140  -32.165 20.359  1.00 58.78  ? 129 GLY I N   1 
ATOM   5760 C  CA  . GLY E 2 129 ? 66.578  -31.532 19.125  1.00 61.03  ? 129 GLY I CA  1 
ATOM   5761 C  C   . GLY E 2 129 ? 65.555  -31.360 18.010  1.00 65.15  ? 129 GLY I C   1 
ATOM   5762 O  O   . GLY E 2 129 ? 65.915  -30.962 16.903  1.00 58.50  ? 129 GLY I O   1 
ATOM   5763 N  N   . ASP E 2 130 ? 64.285  -31.647 18.286  1.00 62.03  ? 130 ASP I N   1 
ATOM   5764 C  CA  . ASP E 2 130 ? 63.226  -31.437 17.295  1.00 60.46  ? 130 ASP I CA  1 
ATOM   5765 C  C   . ASP E 2 130 ? 63.128  -29.955 16.897  1.00 75.14  ? 130 ASP I C   1 
ATOM   5766 O  O   . ASP E 2 130 ? 63.699  -29.089 17.563  1.00 78.05  ? 130 ASP I O   1 
ATOM   5767 C  CB  . ASP E 2 130 ? 61.871  -31.944 17.822  1.00 65.01  ? 130 ASP I CB  1 
ATOM   5768 C  CG  . ASP E 2 130 ? 61.638  -33.431 17.539  1.00 61.74  ? 130 ASP I CG  1 
ATOM   5769 O  OD1 . ASP E 2 130 ? 62.569  -34.114 17.049  1.00 60.39  ? 130 ASP I OD1 1 
ATOM   5770 O  OD2 . ASP E 2 130 ? 60.518  -33.918 17.821  1.00 57.00  ? 130 ASP I OD2 1 
ATOM   5771 N  N   . THR E 2 131 ? 62.410  -29.670 15.812  1.00 79.06  ? 131 THR I N   1 
ATOM   5772 C  CA  . THR E 2 131 ? 62.267  -28.299 15.313  1.00 89.32  ? 131 THR I CA  1 
ATOM   5773 C  C   . THR E 2 131 ? 61.010  -27.601 15.848  1.00 95.33  ? 131 THR I C   1 
ATOM   5774 O  O   . THR E 2 131 ? 59.890  -28.022 15.548  1.00 95.26  ? 131 THR I O   1 
ATOM   5775 C  CB  . THR E 2 131 ? 62.236  -28.259 13.769  1.00 88.40  ? 131 THR I CB  1 
ATOM   5776 O  OG1 . THR E 2 131 ? 63.494  -28.709 13.249  1.00 77.44  ? 131 THR I OG1 1 
ATOM   5777 C  CG2 . THR E 2 131 ? 61.965  -26.844 13.275  1.00 90.03  ? 131 THR I CG2 1 
ATOM   5778 N  N   . PRO E 2 132 ? 61.197  -26.526 16.641  1.00 99.90  ? 132 PRO I N   1 
ATOM   5779 C  CA  . PRO E 2 132 ? 60.102  -25.746 17.238  1.00 99.98  ? 132 PRO I CA  1 
ATOM   5780 C  C   . PRO E 2 132 ? 59.654  -24.569 16.360  1.00 99.07  ? 132 PRO I C   1 
ATOM   5781 O  O   . PRO E 2 132 ? 58.900  -24.773 15.404  1.00 92.18  ? 132 PRO I O   1 
ATOM   5782 C  CB  . PRO E 2 132 ? 60.723  -25.236 18.542  1.00 97.28  ? 132 PRO I CB  1 
ATOM   5783 C  CG  . PRO E 2 132 ? 62.192  -25.094 18.224  1.00 90.77  ? 132 PRO I CG  1 
ATOM   5784 C  CD  . PRO E 2 132 ? 62.519  -26.084 17.126  1.00 93.00  ? 132 PRO I CD  1 
ATOM   5785 N  N   . SER E 2 133 ? 60.094  -23.361 16.720  1.00 102.49 ? 133 SER I N   1 
ATOM   5786 C  CA  . SER E 2 133 ? 59.966  -22.146 15.900  1.00 99.87  ? 133 SER I CA  1 
ATOM   5787 C  C   . SER E 2 133 ? 58.591  -21.461 15.891  1.00 95.63  ? 133 SER I C   1 
ATOM   5788 O  O   . SER E 2 133 ? 58.343  -20.566 15.075  1.00 72.99  ? 133 SER I O   1 
ATOM   5789 C  CB  . SER E 2 133 ? 60.477  -22.377 14.469  1.00 101.65 ? 133 SER I CB  1 
ATOM   5790 O  OG  . SER E 2 133 ? 61.857  -22.706 14.470  1.00 95.28  ? 133 SER I OG  1 
ATOM   5791 N  N   . SER E 2 134 ? 57.709  -21.876 16.796  1.00 93.91  ? 134 SER I N   1 
ATOM   5792 C  CA  . SER E 2 134 ? 56.457  -21.156 17.027  1.00 76.96  ? 134 SER I CA  1 
ATOM   5793 C  C   . SER E 2 134 ? 56.078  -21.247 18.500  1.00 74.62  ? 134 SER I C   1 
ATOM   5794 O  O   . SER E 2 134 ? 56.136  -20.252 19.223  1.00 60.83  ? 134 SER I O   1 
ATOM   5795 C  CB  . SER E 2 134 ? 55.326  -21.691 16.146  1.00 75.78  ? 134 SER I CB  1 
ATOM   5796 O  OG  . SER E 2 134 ? 54.176  -20.862 16.241  1.00 59.71  ? 134 SER I OG  1 
ATOM   5797 N  N   . THR E 2 135 ? 55.708  -22.451 18.934  1.00 68.24  ? 135 THR I N   1 
ATOM   5798 C  CA  . THR E 2 135 ? 55.369  -22.715 20.328  1.00 59.60  ? 135 THR I CA  1 
ATOM   5799 C  C   . THR E 2 135 ? 56.052  -24.004 20.803  1.00 55.94  ? 135 THR I C   1 
ATOM   5800 O  O   . THR E 2 135 ? 56.600  -24.759 19.994  1.00 53.10  ? 135 THR I O   1 
ATOM   5801 C  CB  . THR E 2 135 ? 53.846  -22.884 20.497  1.00 52.26  ? 135 THR I CB  1 
ATOM   5802 O  OG1 . THR E 2 135 ? 53.167  -22.145 19.477  1.00 65.20  ? 135 THR I OG1 1 
ATOM   5803 C  CG2 . THR E 2 135 ? 53.392  -22.393 21.868  1.00 59.59  ? 135 THR I CG2 1 
ATOM   5804 N  N   . VAL E 2 136 ? 56.045  -24.252 22.110  1.00 46.15  ? 136 VAL I N   1 
ATOM   5805 C  CA  . VAL E 2 136 ? 56.382  -25.589 22.583  1.00 46.32  ? 136 VAL I CA  1 
ATOM   5806 C  C   . VAL E 2 136 ? 55.256  -26.122 23.461  1.00 36.10  ? 136 VAL I C   1 
ATOM   5807 O  O   . VAL E 2 136 ? 54.700  -25.411 24.298  1.00 34.03  ? 136 VAL I O   1 
ATOM   5808 C  CB  . VAL E 2 136 ? 57.762  -25.671 23.285  1.00 44.46  ? 136 VAL I CB  1 
ATOM   5809 C  CG1 . VAL E 2 136 ? 57.687  -25.164 24.716  1.00 42.00  ? 136 VAL I CG1 1 
ATOM   5810 C  CG2 . VAL E 2 136 ? 58.268  -27.099 23.269  1.00 39.47  ? 136 VAL I CG2 1 
ATOM   5811 N  N   . THR E 2 137 ? 54.883  -27.371 23.226  1.00 39.61  ? 137 THR I N   1 
ATOM   5812 C  CA  . THR E 2 137 ? 53.858  -28.001 24.035  1.00 31.31  ? 137 THR I CA  1 
ATOM   5813 C  C   . THR E 2 137 ? 54.526  -29.004 24.972  1.00 32.17  ? 137 THR I C   1 
ATOM   5814 O  O   . THR E 2 137 ? 55.276  -29.878 24.532  1.00 29.40  ? 137 THR I O   1 
ATOM   5815 C  CB  . THR E 2 137 ? 52.818  -28.691 23.158  1.00 31.32  ? 137 THR I CB  1 
ATOM   5816 O  OG1 . THR E 2 137 ? 52.189  -27.710 22.323  1.00 31.34  ? 137 THR I OG1 1 
ATOM   5817 C  CG2 . THR E 2 137 ? 51.763  -29.389 24.014  1.00 22.03  ? 137 THR I CG2 1 
ATOM   5818 N  N   . LEU E 2 138 ? 54.270  -28.847 26.268  1.00 30.17  ? 138 LEU I N   1 
ATOM   5819 C  CA  . LEU E 2 138 ? 54.810  -29.732 27.287  1.00 21.79  ? 138 LEU I CA  1 
ATOM   5820 C  C   . LEU E 2 138 ? 53.651  -30.401 28.023  1.00 27.98  ? 138 LEU I C   1 
ATOM   5821 O  O   . LEU E 2 138 ? 52.494  -29.994 27.860  1.00 25.08  ? 138 LEU I O   1 
ATOM   5822 C  CB  . LEU E 2 138 ? 55.672  -28.936 28.269  1.00 21.99  ? 138 LEU I CB  1 
ATOM   5823 C  CG  . LEU E 2 138 ? 56.814  -28.111 27.658  1.00 31.90  ? 138 LEU I CG  1 
ATOM   5824 C  CD1 . LEU E 2 138 ? 57.440  -27.191 28.707  1.00 31.40  ? 138 LEU I CD1 1 
ATOM   5825 C  CD2 . LEU E 2 138 ? 57.882  -29.002 27.019  1.00 27.22  ? 138 LEU I CD2 1 
ATOM   5826 N  N   . GLY E 2 139 ? 53.948  -31.413 28.840  1.00 22.75  ? 139 GLY I N   1 
ATOM   5827 C  CA  . GLY E 2 139 ? 52.887  -32.121 29.523  1.00 19.60  ? 139 GLY I CA  1 
ATOM   5828 C  C   . GLY E 2 139 ? 53.296  -33.068 30.634  1.00 24.78  ? 139 GLY I C   1 
ATOM   5829 O  O   . GLY E 2 139 ? 54.475  -33.232 30.944  1.00 21.92  ? 139 GLY I O   1 
ATOM   5830 N  N   . CYS E 2 140 ? 52.294  -33.688 31.243  1.00 22.45  ? 140 CYS I N   1 
ATOM   5831 C  CA  . CYS E 2 140 ? 52.517  -34.723 32.247  1.00 23.31  ? 140 CYS I CA  1 
ATOM   5832 C  C   . CYS E 2 140 ? 51.576  -35.902 31.996  1.00 24.93  ? 140 CYS I C   1 
ATOM   5833 O  O   . CYS E 2 140 ? 50.360  -35.722 31.821  1.00 23.53  ? 140 CYS I O   1 
ATOM   5834 C  CB  . CYS E 2 140 ? 52.283  -34.176 33.667  1.00 21.73  ? 140 CYS I CB  1 
ATOM   5835 S  SG  . CYS E 2 140 ? 53.602  -33.077 34.323  1.00 27.16  ? 140 CYS I SG  1 
ATOM   5836 N  N   . LEU E 2 141 ? 52.152  -37.098 31.979  1.00 21.01  ? 141 LEU I N   1 
ATOM   5837 C  CA  . LEU E 2 141 ? 51.401  -38.344 31.948  1.00 24.57  ? 141 LEU I CA  1 
ATOM   5838 C  C   . LEU E 2 141 ? 51.204  -38.846 33.372  1.00 27.86  ? 141 LEU I C   1 
ATOM   5839 O  O   . LEU E 2 141 ? 52.171  -38.970 34.138  1.00 22.97  ? 141 LEU I O   1 
ATOM   5840 C  CB  . LEU E 2 141 ? 52.152  -39.380 31.118  1.00 24.10  ? 141 LEU I CB  1 
ATOM   5841 C  CG  . LEU E 2 141 ? 51.692  -40.838 31.196  1.00 27.79  ? 141 LEU I CG  1 
ATOM   5842 C  CD1 . LEU E 2 141 ? 50.328  -41.039 30.514  1.00 22.58  ? 141 LEU I CD1 1 
ATOM   5843 C  CD2 . LEU E 2 141 ? 52.731  -41.744 30.565  1.00 24.41  ? 141 LEU I CD2 1 
ATOM   5844 N  N   . VAL E 2 142 ? 49.950  -39.117 33.726  1.00 21.35  ? 142 VAL I N   1 
ATOM   5845 C  CA  . VAL E 2 142 ? 49.573  -39.535 35.077  1.00 21.18  ? 142 VAL I CA  1 
ATOM   5846 C  C   . VAL E 2 142 ? 49.037  -40.953 34.979  1.00 29.14  ? 142 VAL I C   1 
ATOM   5847 O  O   . VAL E 2 142 ? 47.983  -41.183 34.391  1.00 28.61  ? 142 VAL I O   1 
ATOM   5848 C  CB  . VAL E 2 142 ? 48.482  -38.621 35.659  1.00 27.38  ? 142 VAL I CB  1 
ATOM   5849 C  CG1 . VAL E 2 142 ? 48.106  -39.062 37.067  1.00 24.86  ? 142 VAL I CG1 1 
ATOM   5850 C  CG2 . VAL E 2 142 ? 48.951  -37.181 35.659  1.00 19.60  ? 142 VAL I CG2 1 
ATOM   5851 N  N   . LYS E 2 143 ? 49.765  -41.903 35.555  1.00 24.70  ? 143 LYS I N   1 
ATOM   5852 C  CA  . LYS E 2 143 ? 49.583  -43.303 35.193  1.00 25.82  ? 143 LYS I CA  1 
ATOM   5853 C  C   . LYS E 2 143 ? 49.390  -44.191 36.423  1.00 26.15  ? 143 LYS I C   1 
ATOM   5854 O  O   . LYS E 2 143 ? 49.984  -43.946 37.471  1.00 23.70  ? 143 LYS I O   1 
ATOM   5855 C  CB  . LYS E 2 143 ? 50.799  -43.767 34.372  1.00 25.81  ? 143 LYS I CB  1 
ATOM   5856 C  CG  . LYS E 2 143 ? 50.767  -45.191 33.896  1.00 38.30  ? 143 LYS I CG  1 
ATOM   5857 C  CD  . LYS E 2 143 ? 52.042  -45.541 33.145  1.00 33.50  ? 143 LYS I CD  1 
ATOM   5858 C  CE  . LYS E 2 143 ? 51.975  -46.971 32.629  1.00 40.31  ? 143 LYS I CE  1 
ATOM   5859 N  NZ  . LYS E 2 143 ? 53.127  -47.290 31.741  1.00 49.36  ? 143 LYS I NZ  1 
ATOM   5860 N  N   . GLY E 2 144 ? 48.543  -45.210 36.282  1.00 30.72  ? 144 GLY I N   1 
ATOM   5861 C  CA  . GLY E 2 144 ? 48.427  -46.268 37.276  1.00 30.73  ? 144 GLY I CA  1 
ATOM   5862 C  C   . GLY E 2 144 ? 47.753  -45.916 38.589  1.00 29.78  ? 144 GLY I C   1 
ATOM   5863 O  O   . GLY E 2 144 ? 48.171  -46.395 39.642  1.00 31.39  ? 144 GLY I O   1 
ATOM   5864 N  N   . TYR E 2 145 ? 46.695  -45.107 38.544  1.00 26.87  ? 145 TYR I N   1 
ATOM   5865 C  CA  . TYR E 2 145 ? 46.003  -44.725 39.781  1.00 23.72  ? 145 TYR I CA  1 
ATOM   5866 C  C   . TYR E 2 145 ? 44.622  -45.368 39.970  1.00 24.53  ? 145 TYR I C   1 
ATOM   5867 O  O   . TYR E 2 145 ? 43.965  -45.781 39.013  1.00 25.81  ? 145 TYR I O   1 
ATOM   5868 C  CB  . TYR E 2 145 ? 45.911  -43.207 39.933  1.00 22.26  ? 145 TYR I CB  1 
ATOM   5869 C  CG  . TYR E 2 145 ? 45.055  -42.501 38.894  1.00 22.03  ? 145 TYR I CG  1 
ATOM   5870 C  CD1 . TYR E 2 145 ? 45.618  -42.003 37.719  1.00 20.64  ? 145 TYR I CD1 1 
ATOM   5871 C  CD2 . TYR E 2 145 ? 43.694  -42.288 39.114  1.00 24.69  ? 145 TYR I CD2 1 
ATOM   5872 C  CE1 . TYR E 2 145 ? 44.849  -41.327 36.782  1.00 18.90  ? 145 TYR I CE1 1 
ATOM   5873 C  CE2 . TYR E 2 145 ? 42.908  -41.610 38.182  1.00 19.95  ? 145 TYR I CE2 1 
ATOM   5874 C  CZ  . TYR E 2 145 ? 43.484  -41.138 37.019  1.00 23.61  ? 145 TYR I CZ  1 
ATOM   5875 O  OH  . TYR E 2 145 ? 42.691  -40.488 36.101  1.00 27.25  ? 145 TYR I OH  1 
ATOM   5876 N  N   . LEU E 2 146 ? 44.190  -45.447 41.219  1.00 22.80  ? 146 LEU I N   1 
ATOM   5877 C  CA  . LEU E 2 146 ? 42.891  -46.032 41.548  1.00 26.81  ? 146 LEU I CA  1 
ATOM   5878 C  C   . LEU E 2 146 ? 42.503  -45.569 42.936  1.00 30.51  ? 146 LEU I C   1 
ATOM   5879 O  O   . LEU E 2 146 ? 43.348  -45.533 43.832  1.00 27.90  ? 146 LEU I O   1 
ATOM   5880 C  CB  . LEU E 2 146 ? 42.977  -47.563 41.519  1.00 29.51  ? 146 LEU I CB  1 
ATOM   5881 C  CG  . LEU E 2 146 ? 41.672  -48.349 41.703  1.00 37.02  ? 146 LEU I CG  1 
ATOM   5882 C  CD1 . LEU E 2 146 ? 40.879  -48.305 40.415  1.00 41.03  ? 146 LEU I CD1 1 
ATOM   5883 C  CD2 . LEU E 2 146 ? 41.950  -49.781 42.112  1.00 44.37  ? 146 LEU I CD2 1 
ATOM   5884 N  N   . PRO E 2 147 ? 41.241  -45.155 43.120  1.00 27.93  ? 147 PRO I N   1 
ATOM   5885 C  CA  . PRO E 2 147 ? 40.229  -44.952 42.085  1.00 33.21  ? 147 PRO I CA  1 
ATOM   5886 C  C   . PRO E 2 147 ? 40.303  -43.526 41.546  1.00 29.59  ? 147 PRO I C   1 
ATOM   5887 O  O   . PRO E 2 147 ? 41.211  -42.769 41.886  1.00 26.08  ? 147 PRO I O   1 
ATOM   5888 C  CB  . PRO E 2 147 ? 38.924  -45.112 42.864  1.00 27.38  ? 147 PRO I CB  1 
ATOM   5889 C  CG  . PRO E 2 147 ? 39.238  -44.511 44.180  1.00 26.54  ? 147 PRO I CG  1 
ATOM   5890 C  CD  . PRO E 2 147 ? 40.697  -44.887 44.460  1.00 28.59  ? 147 PRO I CD  1 
ATOM   5891 N  N   . GLU E 2 148 ? 39.339  -43.168 40.712  1.00 22.57  ? 148 GLU I N   1 
ATOM   5892 C  CA  . GLU E 2 148 ? 39.194  -41.806 40.227  1.00 23.10  ? 148 GLU I CA  1 
ATOM   5893 C  C   . GLU E 2 148 ? 38.674  -40.919 41.352  1.00 29.60  ? 148 GLU I C   1 
ATOM   5894 O  O   . GLU E 2 148 ? 38.026  -41.415 42.275  1.00 27.20  ? 148 GLU I O   1 
ATOM   5895 C  CB  . GLU E 2 148 ? 38.190  -41.782 39.079  1.00 31.55  ? 148 GLU I CB  1 
ATOM   5896 C  CG  . GLU E 2 148 ? 38.711  -42.335 37.784  1.00 28.53  ? 148 GLU I CG  1 
ATOM   5897 C  CD  . GLU E 2 148 ? 37.854  -41.891 36.623  1.00 37.25  ? 148 GLU I CD  1 
ATOM   5898 O  OE1 . GLU E 2 148 ? 36.681  -42.310 36.563  1.00 40.90  ? 148 GLU I OE1 1 
ATOM   5899 O  OE2 . GLU E 2 148 ? 38.341  -41.095 35.796  1.00 42.02  ? 148 GLU I OE2 1 
ATOM   5900 N  N   . PRO E 2 149 ? 38.931  -39.598 41.273  1.00 25.90  ? 149 PRO I N   1 
ATOM   5901 C  CA  . PRO E 2 149 ? 39.654  -38.877 40.217  1.00 30.72  ? 149 PRO I CA  1 
ATOM   5902 C  C   . PRO E 2 149 ? 41.043  -38.417 40.628  1.00 27.87  ? 149 PRO I C   1 
ATOM   5903 O  O   . PRO E 2 149 ? 41.435  -38.569 41.782  1.00 25.95  ? 149 PRO I O   1 
ATOM   5904 C  CB  . PRO E 2 149 ? 38.796  -37.629 40.041  1.00 33.02  ? 149 PRO I CB  1 
ATOM   5905 C  CG  . PRO E 2 149 ? 38.354  -37.317 41.473  1.00 31.68  ? 149 PRO I CG  1 
ATOM   5906 C  CD  . PRO E 2 149 ? 38.274  -38.658 42.200  1.00 26.68  ? 149 PRO I CD  1 
ATOM   5907 N  N   . VAL E 2 150 ? 41.783  -37.862 39.675  1.00 26.05  ? 150 VAL I N   1 
ATOM   5908 C  CA  . VAL E 2 150 ? 42.924  -37.008 39.998  1.00 29.68  ? 150 VAL I CA  1 
ATOM   5909 C  C   . VAL E 2 150 ? 42.574  -35.592 39.542  1.00 29.93  ? 150 VAL I C   1 
ATOM   5910 O  O   . VAL E 2 150 ? 41.708  -35.419 38.680  1.00 22.83  ? 150 VAL I O   1 
ATOM   5911 C  CB  . VAL E 2 150 ? 44.239  -37.459 39.308  1.00 25.87  ? 150 VAL I CB  1 
ATOM   5912 C  CG1 . VAL E 2 150 ? 44.747  -38.780 39.889  1.00 23.94  ? 150 VAL I CG1 1 
ATOM   5913 C  CG2 . VAL E 2 150 ? 44.068  -37.543 37.796  1.00 23.94  ? 150 VAL I CG2 1 
ATOM   5914 N  N   . THR E 2 151 ? 43.216  -34.589 40.133  1.00 22.96  ? 151 THR I N   1 
ATOM   5915 C  CA  . THR E 2 151 ? 43.086  -33.210 39.653  1.00 28.32  ? 151 THR I CA  1 
ATOM   5916 C  C   . THR E 2 151 ? 44.459  -32.720 39.203  1.00 31.44  ? 151 THR I C   1 
ATOM   5917 O  O   . THR E 2 151 ? 45.454  -32.928 39.897  1.00 29.91  ? 151 THR I O   1 
ATOM   5918 C  CB  . THR E 2 151 ? 42.571  -32.262 40.752  1.00 30.55  ? 151 THR I CB  1 
ATOM   5919 O  OG1 . THR E 2 151 ? 43.470  -32.299 41.864  1.00 38.89  ? 151 THR I OG1 1 
ATOM   5920 C  CG2 . THR E 2 151 ? 41.200  -32.686 41.231  1.00 29.30  ? 151 THR I CG2 1 
ATOM   5921 N  N   . VAL E 2 152 ? 44.519  -32.084 38.041  1.00 23.90  ? 152 VAL I N   1 
ATOM   5922 C  CA  . VAL E 2 152 ? 45.778  -31.567 37.530  1.00 24.15  ? 152 VAL I CA  1 
ATOM   5923 C  C   . VAL E 2 152 ? 45.706  -30.046 37.388  1.00 30.76  ? 152 VAL I C   1 
ATOM   5924 O  O   . VAL E 2 152 ? 44.768  -29.527 36.781  1.00 26.11  ? 152 VAL I O   1 
ATOM   5925 C  CB  . VAL E 2 152 ? 46.122  -32.165 36.153  1.00 25.96  ? 152 VAL I CB  1 
ATOM   5926 C  CG1 . VAL E 2 152 ? 47.445  -31.602 35.644  1.00 22.26  ? 152 VAL I CG1 1 
ATOM   5927 C  CG2 . VAL E 2 152 ? 46.170  -33.703 36.218  1.00 25.15  ? 152 VAL I CG2 1 
ATOM   5928 N  N   . THR E 2 153 ? 46.689  -29.343 37.950  1.00 23.65  ? 153 THR I N   1 
ATOM   5929 C  CA  . THR E 2 153 ? 46.860  -27.913 37.691  1.00 25.00  ? 153 THR I CA  1 
ATOM   5930 C  C   . THR E 2 153 ? 48.272  -27.654 37.192  1.00 27.30  ? 153 THR I C   1 
ATOM   5931 O  O   . THR E 2 153 ? 49.145  -28.515 37.301  1.00 23.76  ? 153 THR I O   1 
ATOM   5932 C  CB  . THR E 2 153 ? 46.652  -27.041 38.951  1.00 27.55  ? 153 THR I CB  1 
ATOM   5933 O  OG1 . THR E 2 153 ? 47.579  -27.438 39.970  1.00 26.96  ? 153 THR I OG1 1 
ATOM   5934 C  CG2 . THR E 2 153 ? 45.219  -27.155 39.473  1.00 27.09  ? 153 THR I CG2 1 
ATOM   5935 N  N   . TRP E 2 154 ? 48.486  -26.463 36.650  1.00 22.45  ? 154 TRP I N   1 
ATOM   5936 C  CA  . TRP E 2 154 ? 49.808  -26.033 36.214  1.00 26.30  ? 154 TRP I CA  1 
ATOM   5937 C  C   . TRP E 2 154 ? 50.206  -24.760 36.959  1.00 29.16  ? 154 TRP I C   1 
ATOM   5938 O  O   . TRP E 2 154 ? 49.389  -23.855 37.122  1.00 25.36  ? 154 TRP I O   1 
ATOM   5939 C  CB  . TRP E 2 154 ? 49.812  -25.801 34.705  1.00 24.91  ? 154 TRP I CB  1 
ATOM   5940 C  CG  . TRP E 2 154 ? 49.707  -27.083 33.931  1.00 24.99  ? 154 TRP I CG  1 
ATOM   5941 C  CD1 . TRP E 2 154 ? 48.560  -27.702 33.512  1.00 23.51  ? 154 TRP I CD1 1 
ATOM   5942 C  CD2 . TRP E 2 154 ? 50.794  -27.916 33.503  1.00 23.44  ? 154 TRP I CD2 1 
ATOM   5943 N  NE1 . TRP E 2 154 ? 48.871  -28.863 32.835  1.00 25.67  ? 154 TRP I NE1 1 
ATOM   5944 C  CE2 . TRP E 2 154 ? 50.236  -29.012 32.812  1.00 24.39  ? 154 TRP I CE2 1 
ATOM   5945 C  CE3 . TRP E 2 154 ? 52.188  -27.827 33.617  1.00 22.31  ? 154 TRP I CE3 1 
ATOM   5946 C  CZ2 . TRP E 2 154 ? 51.023  -30.019 32.251  1.00 23.78  ? 154 TRP I CZ2 1 
ATOM   5947 C  CZ3 . TRP E 2 154 ? 52.964  -28.826 33.070  1.00 22.94  ? 154 TRP I CZ3 1 
ATOM   5948 C  CH2 . TRP E 2 154 ? 52.380  -29.914 32.396  1.00 23.20  ? 154 TRP I CH2 1 
ATOM   5949 N  N   . ASN E 2 155 ? 51.458  -24.718 37.409  1.00 27.55  ? 155 ASN I N   1 
ATOM   5950 C  CA  . ASN E 2 155 ? 51.977  -23.649 38.259  1.00 30.97  ? 155 ASN I CA  1 
ATOM   5951 C  C   . ASN E 2 155 ? 50.994  -23.217 39.340  1.00 34.00  ? 155 ASN I C   1 
ATOM   5952 O  O   . ASN E 2 155 ? 50.675  -22.034 39.482  1.00 32.48  ? 155 ASN I O   1 
ATOM   5953 C  CB  . ASN E 2 155 ? 52.460  -22.459 37.418  1.00 28.27  ? 155 ASN I CB  1 
ATOM   5954 C  CG  . ASN E 2 155 ? 53.604  -22.833 36.497  1.00 35.53  ? 155 ASN I CG  1 
ATOM   5955 O  OD1 . ASN E 2 155 ? 54.180  -23.915 36.622  1.00 34.32  ? 155 ASN I OD1 1 
ATOM   5956 N  ND2 . ASN E 2 155 ? 53.951  -21.935 35.577  1.00 32.61  ? 155 ASN I ND2 1 
ATOM   5957 N  N   . SER E 2 156 ? 50.492  -24.205 40.071  1.00 27.12  ? 156 SER I N   1 
ATOM   5958 C  CA  . SER E 2 156 ? 49.587  -23.987 41.195  1.00 27.02  ? 156 SER I CA  1 
ATOM   5959 C  C   . SER E 2 156 ? 48.330  -23.206 40.822  1.00 31.86  ? 156 SER I C   1 
ATOM   5960 O  O   . SER E 2 156 ? 47.744  -22.512 41.648  1.00 31.89  ? 156 SER I O   1 
ATOM   5961 C  CB  . SER E 2 156 ? 50.330  -23.341 42.374  1.00 31.30  ? 156 SER I CB  1 
ATOM   5962 O  OG  . SER E 2 156 ? 51.493  -24.095 42.704  1.00 36.05  ? 156 SER I OG  1 
ATOM   5963 N  N   . GLY E 2 157 ? 47.913  -23.332 39.571  1.00 28.85  ? 157 GLY I N   1 
ATOM   5964 C  CA  . GLY E 2 157 ? 46.670  -22.728 39.128  1.00 31.48  ? 157 GLY I CA  1 
ATOM   5965 C  C   . GLY E 2 157 ? 46.830  -21.353 38.504  1.00 33.41  ? 157 GLY I C   1 
ATOM   5966 O  O   . GLY E 2 157 ? 45.845  -20.723 38.150  1.00 35.75  ? 157 GLY I O   1 
ATOM   5967 N  N   . THR E 2 158 ? 48.065  -20.882 38.361  1.00 39.69  ? 158 THR I N   1 
ATOM   5968 C  CA  . THR E 2 158 ? 48.304  -19.578 37.741  1.00 36.05  ? 158 THR I CA  1 
ATOM   5969 C  C   . THR E 2 158 ? 48.489  -19.695 36.230  1.00 39.80  ? 158 THR I C   1 
ATOM   5970 O  O   . THR E 2 158 ? 48.448  -18.695 35.512  1.00 37.28  ? 158 THR I O   1 
ATOM   5971 C  CB  . THR E 2 158 ? 49.534  -18.880 38.331  1.00 35.25  ? 158 THR I CB  1 
ATOM   5972 O  OG1 . THR E 2 158 ? 50.710  -19.626 37.997  1.00 34.90  ? 158 THR I OG1 1 
ATOM   5973 C  CG2 . THR E 2 158 ? 49.405  -18.750 39.849  1.00 26.71  ? 158 THR I CG2 1 
ATOM   5974 N  N   . LEU E 2 159 ? 48.701  -20.918 35.752  1.00 35.16  ? 159 LEU I N   1 
ATOM   5975 C  CA  . LEU E 2 159 ? 48.779  -21.179 34.314  1.00 37.06  ? 159 LEU I CA  1 
ATOM   5976 C  C   . LEU E 2 159 ? 47.512  -21.895 33.873  1.00 37.93  ? 159 LEU I C   1 
ATOM   5977 O  O   . LEU E 2 159 ? 47.269  -23.041 34.230  1.00 38.64  ? 159 LEU I O   1 
ATOM   5978 C  CB  . LEU E 2 159 ? 50.031  -21.990 33.967  1.00 38.51  ? 159 LEU I CB  1 
ATOM   5979 C  CG  . LEU E 2 159 ? 50.260  -22.372 32.502  1.00 36.16  ? 159 LEU I CG  1 
ATOM   5980 C  CD1 . LEU E 2 159 ? 50.013  -21.179 31.595  1.00 45.11  ? 159 LEU I CD1 1 
ATOM   5981 C  CD2 . LEU E 2 159 ? 51.680  -22.909 32.316  1.00 29.50  ? 159 LEU I CD2 1 
ATOM   5982 N  N   . THR E 2 160 ? 46.706  -21.204 33.082  1.00 43.36  ? 160 THR I N   1 
ATOM   5983 C  CA  . THR E 2 160 ? 45.320  -21.585 32.876  1.00 40.11  ? 160 THR I CA  1 
ATOM   5984 C  C   . THR E 2 160 ? 44.981  -21.733 31.390  1.00 42.70  ? 160 THR I C   1 
ATOM   5985 O  O   . THR E 2 160 ? 44.219  -22.621 30.993  1.00 40.71  ? 160 THR I O   1 
ATOM   5986 C  CB  . THR E 2 160 ? 44.402  -20.512 33.515  1.00 49.91  ? 160 THR I CB  1 
ATOM   5987 O  OG1 . THR E 2 160 ? 43.050  -20.693 33.083  1.00 52.12  ? 160 THR I OG1 1 
ATOM   5988 C  CG2 . THR E 2 160 ? 44.876  -19.110 33.126  1.00 49.31  ? 160 THR I CG2 1 
ATOM   5989 N  N   . ASN E 2 161 ? 45.561  -20.861 30.573  1.00 34.99  ? 161 ASN I N   1 
ATOM   5990 C  CA  . ASN E 2 161 ? 45.286  -20.848 29.143  1.00 46.17  ? 161 ASN I CA  1 
ATOM   5991 C  C   . ASN E 2 161 ? 46.179  -21.821 28.400  1.00 38.70  ? 161 ASN I C   1 
ATOM   5992 O  O   . ASN E 2 161 ? 47.369  -21.952 28.703  1.00 41.02  ? 161 ASN I O   1 
ATOM   5993 C  CB  . ASN E 2 161 ? 45.475  -19.443 28.569  1.00 41.77  ? 161 ASN I CB  1 
ATOM   5994 C  CG  . ASN E 2 161 ? 44.541  -18.426 29.197  1.00 46.61  ? 161 ASN I CG  1 
ATOM   5995 O  OD1 . ASN E 2 161 ? 43.351  -18.685 29.378  1.00 47.66  ? 161 ASN I OD1 1 
ATOM   5996 N  ND2 . ASN E 2 161 ? 45.078  -17.264 29.534  1.00 40.24  ? 161 ASN I ND2 1 
ATOM   5997 N  N   . GLY E 2 162 ? 45.605  -22.491 27.414  1.00 33.49  ? 162 GLY I N   1 
ATOM   5998 C  CA  . GLY E 2 162 ? 46.380  -23.379 26.567  1.00 36.12  ? 162 GLY I CA  1 
ATOM   5999 C  C   . GLY E 2 162 ? 46.591  -24.733 27.220  1.00 36.00  ? 162 GLY I C   1 
ATOM   6000 O  O   . GLY E 2 162 ? 47.518  -25.463 26.863  1.00 40.79  ? 162 GLY I O   1 
ATOM   6001 N  N   . VAL E 2 163 ? 45.729  -25.067 28.179  1.00 29.78  ? 163 VAL I N   1 
ATOM   6002 C  CA  . VAL E 2 163 ? 45.820  -26.342 28.880  1.00 30.14  ? 163 VAL I CA  1 
ATOM   6003 C  C   . VAL E 2 163 ? 44.775  -27.327 28.367  1.00 30.67  ? 163 VAL I C   1 
ATOM   6004 O  O   . VAL E 2 163 ? 43.585  -27.009 28.322  1.00 28.06  ? 163 VAL I O   1 
ATOM   6005 C  CB  . VAL E 2 163 ? 45.637  -26.163 30.405  1.00 32.53  ? 163 VAL I CB  1 
ATOM   6006 C  CG1 . VAL E 2 163 ? 45.597  -27.518 31.113  1.00 33.40  ? 163 VAL I CG1 1 
ATOM   6007 C  CG2 . VAL E 2 163 ? 46.747  -25.309 30.981  1.00 28.25  ? 163 VAL I CG2 1 
ATOM   6008 N  N   . ARG E 2 164 ? 45.216  -28.519 27.971  1.00 24.78  ? 164 ARG I N   1 
ATOM   6009 C  CA  . ARG E 2 164 ? 44.281  -29.587 27.617  1.00 27.26  ? 164 ARG I CA  1 
ATOM   6010 C  C   . ARG E 2 164 ? 44.508  -30.794 28.515  1.00 26.84  ? 164 ARG I C   1 
ATOM   6011 O  O   . ARG E 2 164 ? 45.594  -31.363 28.513  1.00 20.69  ? 164 ARG I O   1 
ATOM   6012 C  CB  . ARG E 2 164 ? 44.436  -30.017 26.156  1.00 27.22  ? 164 ARG I CB  1 
ATOM   6013 C  CG  . ARG E 2 164 ? 43.781  -29.084 25.141  1.00 31.87  ? 164 ARG I CG  1 
ATOM   6014 C  CD  . ARG E 2 164 ? 44.788  -28.103 24.608  1.00 41.67  ? 164 ARG I CD  1 
ATOM   6015 N  NE  . ARG E 2 164 ? 45.757  -28.728 23.709  1.00 46.67  ? 164 ARG I NE  1 
ATOM   6016 C  CZ  . ARG E 2 164 ? 47.006  -28.296 23.546  1.00 50.22  ? 164 ARG I CZ  1 
ATOM   6017 N  NH1 . ARG E 2 164 ? 47.824  -28.918 22.700  1.00 35.70  ? 164 ARG I NH1 1 
ATOM   6018 N  NH2 . ARG E 2 164 ? 47.440  -27.243 24.236  1.00 40.53  ? 164 ARG I NH2 1 
ATOM   6019 N  N   . THR E 2 165 ? 43.484  -31.173 29.275  1.00 23.45  ? 165 THR I N   1 
ATOM   6020 C  CA  . THR E 2 165 ? 43.543  -32.338 30.154  1.00 24.76  ? 165 THR I CA  1 
ATOM   6021 C  C   . THR E 2 165 ? 42.529  -33.374 29.691  1.00 22.99  ? 165 THR I C   1 
ATOM   6022 O  O   . THR E 2 165 ? 41.317  -33.187 29.811  1.00 27.77  ? 165 THR I O   1 
ATOM   6023 C  CB  . THR E 2 165 ? 43.277  -31.947 31.622  1.00 29.71  ? 165 THR I CB  1 
ATOM   6024 O  OG1 . THR E 2 165 ? 44.256  -30.992 32.029  1.00 25.77  ? 165 THR I OG1 1 
ATOM   6025 C  CG2 . THR E 2 165 ? 43.359  -33.174 32.532  1.00 22.98  ? 165 THR I CG2 1 
ATOM   6026 N  N   . PHE E 2 166 ? 43.041  -34.472 29.144  1.00 22.82  ? 166 PHE I N   1 
ATOM   6027 C  CA  . PHE E 2 166 ? 42.209  -35.469 28.482  1.00 23.63  ? 166 PHE I CA  1 
ATOM   6028 C  C   . PHE E 2 166 ? 41.472  -36.295 29.501  1.00 24.43  ? 166 PHE I C   1 
ATOM   6029 O  O   . PHE E 2 166 ? 41.952  -36.434 30.625  1.00 24.53  ? 166 PHE I O   1 
ATOM   6030 C  CB  . PHE E 2 166 ? 43.081  -36.345 27.574  1.00 20.88  ? 166 PHE I CB  1 
ATOM   6031 C  CG  . PHE E 2 166 ? 43.725  -35.573 26.461  1.00 22.55  ? 166 PHE I CG  1 
ATOM   6032 C  CD1 . PHE E 2 166 ? 43.048  -35.354 25.277  1.00 17.05  ? 166 PHE I CD1 1 
ATOM   6033 C  CD2 . PHE E 2 166 ? 44.979  -35.018 26.619  1.00 18.49  ? 166 PHE I CD2 1 
ATOM   6034 C  CE1 . PHE E 2 166 ? 43.626  -34.613 24.256  1.00 16.15  ? 166 PHE I CE1 1 
ATOM   6035 C  CE2 . PHE E 2 166 ? 45.557  -34.270 25.602  1.00 23.48  ? 166 PHE I CE2 1 
ATOM   6036 C  CZ  . PHE E 2 166 ? 44.875  -34.072 24.418  1.00 19.50  ? 166 PHE I CZ  1 
ATOM   6037 N  N   . PRO E 2 167 ? 40.282  -36.801 29.133  1.00 20.68  ? 167 PRO I N   1 
ATOM   6038 C  CA  . PRO E 2 167 ? 39.520  -37.647 30.058  1.00 23.43  ? 167 PRO I CA  1 
ATOM   6039 C  C   . PRO E 2 167 ? 40.296  -38.922 30.361  1.00 25.30  ? 167 PRO I C   1 
ATOM   6040 O  O   . PRO E 2 167 ? 41.052  -39.409 29.508  1.00 20.82  ? 167 PRO I O   1 
ATOM   6041 C  CB  . PRO E 2 167 ? 38.244  -37.984 29.273  1.00 26.03  ? 167 PRO I CB  1 
ATOM   6042 C  CG  . PRO E 2 167 ? 38.123  -36.877 28.239  1.00 29.46  ? 167 PRO I CG  1 
ATOM   6043 C  CD  . PRO E 2 167 ? 39.548  -36.539 27.878  1.00 23.56  ? 167 PRO I CD  1 
ATOM   6044 N  N   . SER E 2 168 ? 40.115  -39.458 31.557  1.00 17.96  ? 168 SER I N   1 
ATOM   6045 C  CA  . SER E 2 168 ? 40.893  -40.616 31.972  1.00 25.71  ? 168 SER I CA  1 
ATOM   6046 C  C   . SER E 2 168 ? 40.428  -41.828 31.180  1.00 27.11  ? 168 SER I C   1 
ATOM   6047 O  O   . SER E 2 168 ? 39.321  -41.840 30.629  1.00 26.40  ? 168 SER I O   1 
ATOM   6048 C  CB  . SER E 2 168 ? 40.652  -40.872 33.446  1.00 28.69  ? 168 SER I CB  1 
ATOM   6049 O  OG  . SER E 2 168 ? 39.312  -41.304 33.605  1.00 32.73  ? 168 SER I OG  1 
ATOM   6050 N  N   . VAL E 2 169 ? 41.278  -42.839 31.105  1.00 27.69  ? 169 VAL I N   1 
ATOM   6051 C  CA  . VAL E 2 169 ? 40.900  -44.131 30.533  1.00 26.44  ? 169 VAL I CA  1 
ATOM   6052 C  C   . VAL E 2 169 ? 41.304  -45.233 31.503  1.00 28.21  ? 169 VAL I C   1 
ATOM   6053 O  O   . VAL E 2 169 ? 42.384  -45.188 32.105  1.00 30.47  ? 169 VAL I O   1 
ATOM   6054 C  CB  . VAL E 2 169 ? 41.551  -44.403 29.152  1.00 34.51  ? 169 VAL I CB  1 
ATOM   6055 C  CG1 . VAL E 2 169 ? 41.027  -43.427 28.087  1.00 36.43  ? 169 VAL I CG1 1 
ATOM   6056 C  CG2 . VAL E 2 169 ? 43.063  -44.333 29.237  1.00 40.59  ? 169 VAL I CG2 1 
ATOM   6057 N  N   . ARG E 2 170 ? 40.420  -46.210 31.669  1.00 32.45  ? 170 ARG I N   1 
ATOM   6058 C  CA  . ARG E 2 170 ? 40.688  -47.348 32.537  1.00 35.78  ? 170 ARG I CA  1 
ATOM   6059 C  C   . ARG E 2 170 ? 41.403  -48.443 31.777  1.00 36.07  ? 170 ARG I C   1 
ATOM   6060 O  O   . ARG E 2 170 ? 40.863  -48.989 30.825  1.00 38.58  ? 170 ARG I O   1 
ATOM   6061 C  CB  . ARG E 2 170 ? 39.377  -47.893 33.096  1.00 36.37  ? 170 ARG I CB  1 
ATOM   6062 C  CG  . ARG E 2 170 ? 39.524  -49.045 34.084  1.00 34.91  ? 170 ARG I CG  1 
ATOM   6063 C  CD  . ARG E 2 170 ? 38.218  -49.225 34.843  1.00 48.57  ? 170 ARG I CD  1 
ATOM   6064 N  NE  . ARG E 2 170 ? 38.128  -50.514 35.521  1.00 60.64  ? 170 ARG I NE  1 
ATOM   6065 C  CZ  . ARG E 2 170 ? 37.977  -50.666 36.833  1.00 66.13  ? 170 ARG I CZ  1 
ATOM   6066 N  NH1 . ARG E 2 170 ? 37.890  -49.605 37.630  1.00 58.92  ? 170 ARG I NH1 1 
ATOM   6067 N  NH2 . ARG E 2 170 ? 37.905  -51.887 37.350  1.00 65.44  ? 170 ARG I NH2 1 
ATOM   6068 N  N   . GLN E 2 171 ? 42.603  -48.787 32.221  1.00 43.19  ? 171 GLN I N   1 
ATOM   6069 C  CA  . GLN E 2 171 ? 43.348  -49.872 31.596  1.00 42.37  ? 171 GLN I CA  1 
ATOM   6070 C  C   . GLN E 2 171 ? 42.760  -51.222 32.031  1.00 44.75  ? 171 GLN I C   1 
ATOM   6071 O  O   . GLN E 2 171 ? 41.823  -51.270 32.834  1.00 49.96  ? 171 GLN I O   1 
ATOM   6072 C  CB  . GLN E 2 171 ? 44.829  -49.778 31.971  1.00 51.94  ? 171 GLN I CB  1 
ATOM   6073 C  CG  . GLN E 2 171 ? 45.399  -48.356 31.957  1.00 45.30  ? 171 GLN I CG  1 
ATOM   6074 C  CD  . GLN E 2 171 ? 45.296  -47.687 30.593  1.00 55.99  ? 171 GLN I CD  1 
ATOM   6075 O  OE1 . GLN E 2 171 ? 44.848  -46.544 30.485  1.00 48.80  ? 171 GLN I OE1 1 
ATOM   6076 N  NE2 . GLN E 2 171 ? 45.719  -48.394 29.547  1.00 59.87  ? 171 GLN I NE2 1 
ATOM   6077 N  N   . SER E 2 172 ? 43.306  -52.315 31.503  1.00 52.02  ? 172 SER I N   1 
ATOM   6078 C  CA  . SER E 2 172 ? 42.808  -53.657 31.824  1.00 51.76  ? 172 SER I CA  1 
ATOM   6079 C  C   . SER E 2 172 ? 42.976  -53.981 33.308  1.00 56.73  ? 172 SER I C   1 
ATOM   6080 O  O   . SER E 2 172 ? 42.137  -54.662 33.898  1.00 54.92  ? 172 SER I O   1 
ATOM   6081 C  CB  . SER E 2 172 ? 43.501  -54.718 30.959  1.00 54.29  ? 172 SER I CB  1 
ATOM   6082 O  OG  . SER E 2 172 ? 44.907  -54.539 30.957  1.00 53.69  ? 172 SER I OG  1 
ATOM   6083 N  N   . SER E 2 173 ? 44.059  -53.471 33.897  1.00 55.58  ? 173 SER I N   1 
ATOM   6084 C  CA  . SER E 2 173 ? 44.324  -53.564 35.335  1.00 47.27  ? 173 SER I CA  1 
ATOM   6085 C  C   . SER E 2 173 ? 43.164  -53.067 36.167  1.00 51.35  ? 173 SER I C   1 
ATOM   6086 O  O   . SER E 2 173 ? 42.983  -53.458 37.320  1.00 45.28  ? 173 SER I O   1 
ATOM   6087 C  CB  . SER E 2 173 ? 45.516  -52.681 35.689  1.00 44.47  ? 173 SER I CB  1 
ATOM   6088 O  OG  . SER E 2 173 ? 45.309  -51.355 35.228  1.00 49.43  ? 173 SER I OG  1 
ATOM   6089 N  N   . GLY E 2 174 ? 42.394  -52.172 35.578  1.00 46.57  ? 174 GLY I N   1 
ATOM   6090 C  CA  . GLY E 2 174 ? 41.486  -51.378 36.354  1.00 48.68  ? 174 GLY I CA  1 
ATOM   6091 C  C   . GLY E 2 174 ? 42.247  -50.179 36.880  1.00 41.59  ? 174 GLY I C   1 
ATOM   6092 O  O   . GLY E 2 174 ? 41.692  -49.429 37.681  1.00 38.37  ? 174 GLY I O   1 
ATOM   6093 N  N   . LEU E 2 175 ? 43.503  -49.981 36.456  1.00 34.97  ? 175 LEU I N   1 
ATOM   6094 C  CA  . LEU E 2 175 ? 44.153  -48.737 36.861  1.00 33.04  ? 175 LEU I CA  1 
ATOM   6095 C  C   . LEU E 2 175 ? 43.877  -47.662 35.817  1.00 26.32  ? 175 LEU I C   1 
ATOM   6096 O  O   . LEU E 2 175 ? 43.737  -47.953 34.635  1.00 33.63  ? 175 LEU I O   1 
ATOM   6097 C  CB  . LEU E 2 175 ? 45.654  -48.896 37.131  1.00 32.64  ? 175 LEU I CB  1 
ATOM   6098 C  CG  . LEU E 2 175 ? 46.056  -50.018 38.098  1.00 34.51  ? 175 LEU I CG  1 
ATOM   6099 C  CD1 . LEU E 2 175 ? 47.563  -50.071 38.227  1.00 36.39  ? 175 LEU I CD1 1 
ATOM   6100 C  CD2 . LEU E 2 175 ? 45.394  -49.837 39.463  1.00 32.46  ? 175 LEU I CD2 1 
ATOM   6101 N  N   . TYR E 2 176 ? 43.775  -46.418 36.269  1.00 23.54  ? 176 TYR I N   1 
ATOM   6102 C  CA  . TYR E 2 176 ? 43.489  -45.313 35.359  1.00 23.50  ? 176 TYR I CA  1 
ATOM   6103 C  C   . TYR E 2 176 ? 44.730  -44.572 34.900  1.00 23.83  ? 176 TYR I C   1 
ATOM   6104 O  O   . TYR E 2 176 ? 45.763  -44.589 35.568  1.00 25.55  ? 176 TYR I O   1 
ATOM   6105 C  CB  . TYR E 2 176 ? 42.544  -44.335 36.026  1.00 20.16  ? 176 TYR I CB  1 
ATOM   6106 C  CG  . TYR E 2 176 ? 41.163  -44.896 36.224  1.00 24.56  ? 176 TYR I CG  1 
ATOM   6107 C  CD1 . TYR E 2 176 ? 40.167  -44.674 35.280  1.00 27.33  ? 176 TYR I CD1 1 
ATOM   6108 C  CD2 . TYR E 2 176 ? 40.851  -45.672 37.340  1.00 24.38  ? 176 TYR I CD2 1 
ATOM   6109 C  CE1 . TYR E 2 176 ? 38.893  -45.186 35.451  1.00 25.91  ? 176 TYR I CE1 1 
ATOM   6110 C  CE2 . TYR E 2 176 ? 39.581  -46.186 37.515  1.00 25.85  ? 176 TYR I CE2 1 
ATOM   6111 C  CZ  . TYR E 2 176 ? 38.609  -45.940 36.564  1.00 33.02  ? 176 TYR I CZ  1 
ATOM   6112 O  OH  . TYR E 2 176 ? 37.346  -46.453 36.731  1.00 36.43  ? 176 TYR I OH  1 
ATOM   6113 N  N   . SER E 2 177 ? 44.607  -43.920 33.750  1.00 19.12  ? 177 SER I N   1 
ATOM   6114 C  CA  . SER E 2 177 ? 45.660  -43.088 33.210  1.00 26.03  ? 177 SER I CA  1 
ATOM   6115 C  C   . SER E 2 177 ? 45.078  -41.876 32.466  1.00 23.87  ? 177 SER I C   1 
ATOM   6116 O  O   . SER E 2 177 ? 44.046  -41.979 31.793  1.00 21.73  ? 177 SER I O   1 
ATOM   6117 C  CB  . SER E 2 177 ? 46.533  -43.911 32.264  1.00 30.24  ? 177 SER I CB  1 
ATOM   6118 O  OG  . SER E 2 177 ? 47.688  -43.181 31.898  1.00 36.95  ? 177 SER I OG  1 
ATOM   6119 N  N   . LEU E 2 178 ? 45.741  -40.732 32.589  1.00 27.60  ? 178 LEU I N   1 
ATOM   6120 C  CA  . LEU E 2 178 ? 45.429  -39.592 31.730  1.00 28.08  ? 178 LEU I CA  1 
ATOM   6121 C  C   . LEU E 2 178 ? 46.681  -38.774 31.463  1.00 27.33  ? 178 LEU I C   1 
ATOM   6122 O  O   . LEU E 2 178 ? 47.703  -38.968 32.113  1.00 18.93  ? 178 LEU I O   1 
ATOM   6123 C  CB  . LEU E 2 178 ? 44.313  -38.714 32.329  1.00 23.03  ? 178 LEU I CB  1 
ATOM   6124 C  CG  . LEU E 2 178 ? 44.483  -37.955 33.650  1.00 25.38  ? 178 LEU I CG  1 
ATOM   6125 C  CD1 . LEU E 2 178 ? 45.401  -36.722 33.531  1.00 25.22  ? 178 LEU I CD1 1 
ATOM   6126 C  CD2 . LEU E 2 178 ? 43.115  -37.530 34.163  1.00 28.79  ? 178 LEU I CD2 1 
ATOM   6127 N  N   . SER E 2 179 ? 46.573  -37.851 30.510  1.00 24.09  ? 179 SER I N   1 
ATOM   6128 C  CA  . SER E 2 179 ? 47.626  -36.893 30.185  1.00 23.96  ? 179 SER I CA  1 
ATOM   6129 C  C   . SER E 2 179 ? 47.090  -35.469 30.261  1.00 19.99  ? 179 SER I C   1 
ATOM   6130 O  O   . SER E 2 179 ? 45.918  -35.216 29.981  1.00 20.41  ? 179 SER I O   1 
ATOM   6131 C  CB  . SER E 2 179 ? 48.140  -37.127 28.769  1.00 23.70  ? 179 SER I CB  1 
ATOM   6132 O  OG  . SER E 2 179 ? 49.098  -38.168 28.726  1.00 35.21  ? 179 SER I OG  1 
ATOM   6133 N  N   . SER E 2 180 ? 47.954  -34.536 30.616  1.00 21.64  ? 180 SER I N   1 
ATOM   6134 C  CA  . SER E 2 180 ? 47.623  -33.117 30.512  1.00 25.01  ? 180 SER I CA  1 
ATOM   6135 C  C   . SER E 2 180 ? 48.762  -32.415 29.774  1.00 26.32  ? 180 SER I C   1 
ATOM   6136 O  O   . SER E 2 180 ? 49.930  -32.659 30.058  1.00 22.81  ? 180 SER I O   1 
ATOM   6137 C  CB  . SER E 2 180 ? 47.401  -32.506 31.905  1.00 26.99  ? 180 SER I CB  1 
ATOM   6138 O  OG  . SER E 2 180 ? 47.095  -31.112 31.850  1.00 24.91  ? 180 SER I OG  1 
ATOM   6139 N  N   . VAL E 2 181 ? 48.425  -31.568 28.803  1.00 23.92  ? 181 VAL I N   1 
ATOM   6140 C  CA  . VAL E 2 181 ? 49.440  -30.834 28.062  1.00 19.66  ? 181 VAL I CA  1 
ATOM   6141 C  C   . VAL E 2 181 ? 49.150  -29.341 28.055  1.00 25.42  ? 181 VAL I C   1 
ATOM   6142 O  O   . VAL E 2 181 ? 47.994  -28.914 28.185  1.00 27.60  ? 181 VAL I O   1 
ATOM   6143 C  CB  . VAL E 2 181 ? 49.576  -31.315 26.600  1.00 20.45  ? 181 VAL I CB  1 
ATOM   6144 C  CG1 . VAL E 2 181 ? 49.962  -32.789 26.560  1.00 21.78  ? 181 VAL I CG1 1 
ATOM   6145 C  CG2 . VAL E 2 181 ? 48.275  -31.076 25.840  1.00 24.30  ? 181 VAL I CG2 1 
ATOM   6146 N  N   . VAL E 2 182 ? 50.205  -28.550 27.891  1.00 22.64  ? 182 VAL I N   1 
ATOM   6147 C  CA  . VAL E 2 182 ? 50.071  -27.096 27.889  1.00 26.01  ? 182 VAL I CA  1 
ATOM   6148 C  C   . VAL E 2 182 ? 51.037  -26.452 26.882  1.00 28.10  ? 182 VAL I C   1 
ATOM   6149 O  O   . VAL E 2 182 ? 52.205  -26.839 26.762  1.00 29.40  ? 182 VAL I O   1 
ATOM   6150 C  CB  . VAL E 2 182 ? 50.265  -26.499 29.309  1.00 24.92  ? 182 VAL I CB  1 
ATOM   6151 C  CG1 . VAL E 2 182 ? 51.652  -26.826 29.831  1.00 24.94  ? 182 VAL I CG1 1 
ATOM   6152 C  CG2 . VAL E 2 182 ? 50.028  -24.971 29.312  1.00 29.30  ? 182 VAL I CG2 1 
ATOM   6153 N  N   . SER E 2 183 ? 50.528  -25.487 26.133  1.00 31.57  ? 183 SER I N   1 
ATOM   6154 C  CA  . SER E 2 183 ? 51.337  -24.810 25.136  1.00 34.42  ? 183 SER I CA  1 
ATOM   6155 C  C   . SER E 2 183 ? 51.917  -23.550 25.746  1.00 37.28  ? 183 SER I C   1 
ATOM   6156 O  O   . SER E 2 183 ? 51.181  -22.721 26.280  1.00 36.43  ? 183 SER I O   1 
ATOM   6157 C  CB  . SER E 2 183 ? 50.497  -24.470 23.910  1.00 31.98  ? 183 SER I CB  1 
ATOM   6158 O  OG  . SER E 2 183 ? 49.931  -25.644 23.340  1.00 45.60  ? 183 SER I OG  1 
ATOM   6159 N  N   . VAL E 2 184 ? 53.240  -23.437 25.697  1.00 34.87  ? 184 VAL I N   1 
ATOM   6160 C  CA  . VAL E 2 184 ? 53.922  -22.273 26.241  1.00 51.71  ? 184 VAL I CA  1 
ATOM   6161 C  C   . VAL E 2 184 ? 54.934  -21.706 25.261  1.00 60.85  ? 184 VAL I C   1 
ATOM   6162 O  O   . VAL E 2 184 ? 55.596  -22.430 24.501  1.00 57.66  ? 184 VAL I O   1 
ATOM   6163 C  CB  . VAL E 2 184 ? 54.633  -22.488 27.623  1.00 50.94  ? 184 VAL I CB  1 
ATOM   6164 C  CG1 . VAL E 2 184 ? 53.710  -23.066 28.695  1.00 50.36  ? 184 VAL I CG1 1 
ATOM   6165 C  CG2 . VAL E 2 184 ? 56.012  -23.125 27.508  1.00 46.91  ? 184 VAL I CG2 1 
ATOM   6166 N  N   . THR E 2 185 ? 55.041  -20.385 25.292  1.00 65.46  ? 185 THR I N   1 
ATOM   6167 C  CA  . THR E 2 185 ? 55.988  -19.677 24.439  1.00 68.79  ? 185 THR I CA  1 
ATOM   6168 C  C   . THR E 2 185 ? 57.443  -20.132 24.625  1.00 73.70  ? 185 THR I C   1 
ATOM   6169 O  O   . THR E 2 185 ? 57.950  -20.189 25.741  1.00 74.10  ? 185 THR I O   1 
ATOM   6170 C  CB  . THR E 2 185 ? 55.861  -18.156 24.607  1.00 60.01  ? 185 THR I CB  1 
ATOM   6171 O  OG1 . THR E 2 185 ? 55.981  -17.823 25.990  1.00 65.81  ? 185 THR I OG1 1 
ATOM   6172 C  CG2 . THR E 2 185 ? 54.489  -17.694 24.143  1.00 53.78  ? 185 THR I CG2 1 
ATOM   6173 N  N   . SER E 2 186 ? 58.103  -20.408 23.498  1.00 75.97  ? 186 SER I N   1 
ATOM   6174 C  CA  . SER E 2 186 ? 59.451  -20.987 23.441  1.00 74.75  ? 186 SER I CA  1 
ATOM   6175 C  C   . SER E 2 186 ? 60.496  -20.215 24.257  1.00 84.35  ? 186 SER I C   1 
ATOM   6176 O  O   . SER E 2 186 ? 60.444  -18.984 24.341  1.00 80.27  ? 186 SER I O   1 
ATOM   6177 C  CB  . SER E 2 186 ? 59.904  -21.087 21.976  1.00 82.46  ? 186 SER I CB  1 
ATOM   6178 O  OG  . SER E 2 186 ? 60.500  -22.341 21.683  1.00 69.48  ? 186 SER I OG  1 
ATOM   6179 N  N   . SER E 2 187 ? 61.437  -20.956 24.847  1.00 82.92  ? 187 SER I N   1 
ATOM   6180 C  CA  . SER E 2 187 ? 62.526  -20.399 25.666  1.00 85.96  ? 187 SER I CA  1 
ATOM   6181 C  C   . SER E 2 187 ? 62.061  -19.708 26.958  1.00 82.66  ? 187 SER I C   1 
ATOM   6182 O  O   . SER E 2 187 ? 62.722  -18.787 27.447  1.00 73.51  ? 187 SER I O   1 
ATOM   6183 C  CB  . SER E 2 187 ? 63.427  -19.455 24.846  1.00 90.09  ? 187 SER I CB  1 
ATOM   6184 O  OG  . SER E 2 187 ? 64.242  -20.166 23.925  1.00 84.74  ? 187 SER I OG  1 
ATOM   6185 N  N   . SER E 2 188 ? 60.944  -20.167 27.518  1.00 77.52  ? 188 SER I N   1 
ATOM   6186 C  CA  . SER E 2 188 ? 60.365  -19.530 28.704  1.00 78.13  ? 188 SER I CA  1 
ATOM   6187 C  C   . SER E 2 188 ? 60.845  -20.134 30.021  1.00 71.64  ? 188 SER I C   1 
ATOM   6188 O  O   . SER E 2 188 ? 61.729  -20.990 30.043  1.00 71.87  ? 188 SER I O   1 
ATOM   6189 C  CB  . SER E 2 188 ? 58.834  -19.566 28.649  1.00 79.16  ? 188 SER I CB  1 
ATOM   6190 O  OG  . SER E 2 188 ? 58.335  -18.667 27.667  1.00 67.29  ? 188 SER I OG  1 
ATOM   6191 N  N   . GLN E 2 189 ? 60.255  -19.661 31.116  1.00 72.83  ? 189 GLN I N   1 
ATOM   6192 C  CA  . GLN E 2 189 ? 60.548  -20.168 32.454  1.00 84.03  ? 189 GLN I CA  1 
ATOM   6193 C  C   . GLN E 2 189 ? 59.753  -21.445 32.728  1.00 82.79  ? 189 GLN I C   1 
ATOM   6194 O  O   . GLN E 2 189 ? 58.531  -21.455 32.559  1.00 76.47  ? 189 GLN I O   1 
ATOM   6195 C  CB  . GLN E 2 189 ? 60.227  -19.098 33.504  1.00 83.52  ? 189 GLN I CB  1 
ATOM   6196 C  CG  . GLN E 2 189 ? 59.036  -18.210 33.151  1.00 83.70  ? 189 GLN I CG  1 
ATOM   6197 C  CD  . GLN E 2 189 ? 58.728  -17.185 34.231  1.00 94.78  ? 189 GLN I CD  1 
ATOM   6198 O  OE1 . GLN E 2 189 ? 58.115  -16.146 33.968  1.00 88.64  ? 189 GLN I OE1 1 
ATOM   6199 N  NE2 . GLN E 2 189 ? 59.151  -17.476 35.457  1.00 95.02  ? 189 GLN I NE2 1 
ATOM   6200 N  N   . PRO E 2 190 ? 60.449  -22.520 33.159  1.00 83.67  ? 190 PRO I N   1 
ATOM   6201 C  CA  . PRO E 2 190 ? 59.926  -23.889 33.305  1.00 74.55  ? 190 PRO I CA  1 
ATOM   6202 C  C   . PRO E 2 190 ? 58.543  -23.977 33.952  1.00 58.15  ? 190 PRO I C   1 
ATOM   6203 O  O   . PRO E 2 190 ? 58.192  -23.145 34.791  1.00 62.47  ? 190 PRO I O   1 
ATOM   6204 C  CB  . PRO E 2 190 ? 60.981  -24.585 34.184  1.00 74.24  ? 190 PRO I CB  1 
ATOM   6205 C  CG  . PRO E 2 190 ? 61.855  -23.482 34.718  1.00 82.55  ? 190 PRO I CG  1 
ATOM   6206 C  CD  . PRO E 2 190 ? 61.827  -22.423 33.665  1.00 76.46  ? 190 PRO I CD  1 
ATOM   6207 N  N   . VAL E 2 191 ? 57.774  -24.982 33.542  1.00 46.87  ? 191 VAL I N   1 
ATOM   6208 C  CA  . VAL E 2 191 ? 56.412  -25.165 34.015  1.00 38.17  ? 191 VAL I CA  1 
ATOM   6209 C  C   . VAL E 2 191 ? 56.302  -26.417 34.876  1.00 34.77  ? 191 VAL I C   1 
ATOM   6210 O  O   . VAL E 2 191 ? 57.053  -27.376 34.692  1.00 34.82  ? 191 VAL I O   1 
ATOM   6211 C  CB  . VAL E 2 191 ? 55.424  -25.272 32.838  1.00 37.86  ? 191 VAL I CB  1 
ATOM   6212 C  CG1 . VAL E 2 191 ? 55.401  -23.971 32.054  1.00 52.09  ? 191 VAL I CG1 1 
ATOM   6213 C  CG2 . VAL E 2 191 ? 55.797  -26.421 31.937  1.00 34.15  ? 191 VAL I CG2 1 
ATOM   6214 N  N   . THR E 2 192 ? 55.356  -26.408 35.810  1.00 30.34  ? 192 THR I N   1 
ATOM   6215 C  CA  . THR E 2 192 ? 55.215  -27.504 36.764  1.00 31.39  ? 192 THR I CA  1 
ATOM   6216 C  C   . THR E 2 192 ? 53.779  -27.979 36.819  1.00 25.86  ? 192 THR I C   1 
ATOM   6217 O  O   . THR E 2 192 ? 52.880  -27.181 37.052  1.00 26.88  ? 192 THR I O   1 
ATOM   6218 C  CB  . THR E 2 192 ? 55.619  -27.035 38.173  1.00 33.06  ? 192 THR I CB  1 
ATOM   6219 O  OG1 . THR E 2 192 ? 56.960  -26.543 38.138  1.00 31.73  ? 192 THR I OG1 1 
ATOM   6220 C  CG2 . THR E 2 192 ? 55.510  -28.168 39.186  1.00 28.14  ? 192 THR I CG2 1 
ATOM   6221 N  N   . CYS E 2 193 ? 53.550  -29.269 36.585  1.00 28.62  ? 193 CYS I N   1 
ATOM   6222 C  CA  . CYS E 2 193 ? 52.227  -29.823 36.816  1.00 25.18  ? 193 CYS I CA  1 
ATOM   6223 C  C   . CYS E 2 193 ? 52.083  -30.276 38.274  1.00 25.48  ? 193 CYS I C   1 
ATOM   6224 O  O   . CYS E 2 193 ? 53.004  -30.853 38.845  1.00 26.87  ? 193 CYS I O   1 
ATOM   6225 C  CB  . CYS E 2 193 ? 51.938  -30.989 35.865  1.00 26.44  ? 193 CYS I CB  1 
ATOM   6226 S  SG  . CYS E 2 193 ? 52.929  -32.478 36.149  1.00 27.76  ? 193 CYS I SG  1 
ATOM   6227 N  N   . ASN E 2 194 ? 50.922  -30.004 38.859  1.00 23.75  ? 194 ASN I N   1 
ATOM   6228 C  CA  . ASN E 2 194 ? 50.591  -30.411 40.218  1.00 26.08  ? 194 ASN I CA  1 
ATOM   6229 C  C   . ASN E 2 194 ? 49.483  -31.446 40.144  1.00 27.91  ? 194 ASN I C   1 
ATOM   6230 O  O   . ASN E 2 194 ? 48.370  -31.140 39.718  1.00 27.76  ? 194 ASN I O   1 
ATOM   6231 C  CB  . ASN E 2 194 ? 50.099  -29.211 41.054  1.00 27.38  ? 194 ASN I CB  1 
ATOM   6232 C  CG  . ASN E 2 194 ? 50.768  -27.896 40.658  1.00 33.92  ? 194 ASN I CG  1 
ATOM   6233 O  OD1 . ASN E 2 194 ? 50.120  -27.000 40.113  1.00 31.65  ? 194 ASN I OD1 1 
ATOM   6234 N  ND2 . ASN E 2 194 ? 52.065  -27.777 40.935  1.00 30.29  ? 194 ASN I ND2 1 
ATOM   6235 N  N   . VAL E 2 195 ? 49.779  -32.674 40.554  1.00 27.27  ? 195 VAL I N   1 
ATOM   6236 C  CA  . VAL E 2 195 ? 48.825  -33.772 40.402  1.00 24.12  ? 195 VAL I CA  1 
ATOM   6237 C  C   . VAL E 2 195 ? 48.379  -34.234 41.780  1.00 27.33  ? 195 VAL I C   1 
ATOM   6238 O  O   . VAL E 2 195 ? 49.194  -34.696 42.573  1.00 23.96  ? 195 VAL I O   1 
ATOM   6239 C  CB  . VAL E 2 195 ? 49.453  -34.963 39.662  1.00 26.05  ? 195 VAL I CB  1 
ATOM   6240 C  CG1 . VAL E 2 195 ? 48.440  -36.088 39.512  1.00 22.44  ? 195 VAL I CG1 1 
ATOM   6241 C  CG2 . VAL E 2 195 ? 49.998  -34.530 38.296  1.00 25.83  ? 195 VAL I CG2 1 
ATOM   6242 N  N   . ALA E 2 196 ? 47.098  -34.076 42.080  1.00 25.13  ? 196 ALA I N   1 
ATOM   6243 C  CA  . ALA E 2 196 ? 46.575  -34.494 43.373  1.00 24.38  ? 196 ALA I CA  1 
ATOM   6244 C  C   . ALA E 2 196 ? 45.670  -35.707 43.218  1.00 32.21  ? 196 ALA I C   1 
ATOM   6245 O  O   . ALA E 2 196 ? 44.888  -35.787 42.262  1.00 27.25  ? 196 ALA I O   1 
ATOM   6246 C  CB  . ALA E 2 196 ? 45.833  -33.353 44.033  1.00 32.33  ? 196 ALA I CB  1 
ATOM   6247 N  N   . HIS E 2 197 ? 45.794  -36.647 44.158  1.00 22.66  ? 197 HIS I N   1 
ATOM   6248 C  CA  . HIS E 2 197 ? 44.990  -37.858 44.190  1.00 23.19  ? 197 HIS I CA  1 
ATOM   6249 C  C   . HIS E 2 197 ? 44.406  -38.031 45.588  1.00 30.68  ? 197 HIS I C   1 
ATOM   6250 O  O   . HIS E 2 197 ? 45.038  -38.646 46.459  1.00 27.01  ? 197 HIS I O   1 
ATOM   6251 C  CB  . HIS E 2 197 ? 45.830  -39.076 43.816  1.00 20.81  ? 197 HIS I CB  1 
ATOM   6252 C  CG  . HIS E 2 197 ? 45.039  -40.348 43.683  1.00 28.74  ? 197 HIS I CG  1 
ATOM   6253 N  ND1 . HIS E 2 197 ? 45.346  -41.487 44.392  1.00 22.23  ? 197 HIS I ND1 1 
ATOM   6254 C  CD2 . HIS E 2 197 ? 43.965  -40.649 42.914  1.00 22.61  ? 197 HIS I CD2 1 
ATOM   6255 C  CE1 . HIS E 2 197 ? 44.484  -42.447 44.067  1.00 27.89  ? 197 HIS I CE1 1 
ATOM   6256 N  NE2 . HIS E 2 197 ? 43.648  -41.965 43.168  1.00 22.27  ? 197 HIS I NE2 1 
ATOM   6257 N  N   . PRO E 2 198 ? 43.199  -37.480 45.814  1.00 30.95  ? 198 PRO I N   1 
ATOM   6258 C  CA  . PRO E 2 198 ? 42.568  -37.443 47.144  1.00 27.64  ? 198 PRO I CA  1 
ATOM   6259 C  C   . PRO E 2 198 ? 42.463  -38.809 47.835  1.00 29.25  ? 198 PRO I C   1 
ATOM   6260 O  O   . PRO E 2 198 ? 42.621  -38.874 49.053  1.00 33.77  ? 198 PRO I O   1 
ATOM   6261 C  CB  . PRO E 2 198 ? 41.169  -36.879 46.856  1.00 35.03  ? 198 PRO I CB  1 
ATOM   6262 C  CG  . PRO E 2 198 ? 41.343  -36.058 45.611  1.00 31.33  ? 198 PRO I CG  1 
ATOM   6263 C  CD  . PRO E 2 198 ? 42.393  -36.780 44.795  1.00 28.19  ? 198 PRO I CD  1 
ATOM   6264 N  N   . ALA E 2 199 ? 42.233  -39.876 47.080  1.00 28.48  ? 199 ALA I N   1 
ATOM   6265 C  CA  . ALA E 2 199 ? 42.051  -41.202 47.679  1.00 27.75  ? 199 ALA I CA  1 
ATOM   6266 C  C   . ALA E 2 199 ? 43.301  -41.731 48.384  1.00 36.59  ? 199 ALA I C   1 
ATOM   6267 O  O   . ALA E 2 199 ? 43.196  -42.579 49.270  1.00 33.02  ? 199 ALA I O   1 
ATOM   6268 C  CB  . ALA E 2 199 ? 41.589  -42.200 46.652  1.00 28.61  ? 199 ALA I CB  1 
ATOM   6269 N  N   . THR E 2 200 ? 44.477  -41.257 47.979  1.00 29.62  ? 200 THR I N   1 
ATOM   6270 C  CA  . THR E 2 200 ? 45.723  -41.676 48.619  1.00 23.56  ? 200 THR I CA  1 
ATOM   6271 C  C   . THR E 2 200 ? 46.379  -40.540 49.386  1.00 25.74  ? 200 THR I C   1 
ATOM   6272 O  O   . THR E 2 200 ? 47.477  -40.707 49.913  1.00 33.57  ? 200 THR I O   1 
ATOM   6273 C  CB  . THR E 2 200 ? 46.734  -42.238 47.600  1.00 30.57  ? 200 THR I CB  1 
ATOM   6274 O  OG1 . THR E 2 200 ? 46.993  -41.263 46.576  1.00 25.59  ? 200 THR I OG1 1 
ATOM   6275 C  CG2 . THR E 2 200 ? 46.195  -43.508 46.959  1.00 25.43  ? 200 THR I CG2 1 
ATOM   6276 N  N   . ASN E 2 201 ? 45.706  -39.391 49.441  1.00 26.61  ? 201 ASN I N   1 
ATOM   6277 C  CA  . ASN E 2 201 ? 46.207  -38.203 50.128  1.00 29.39  ? 201 ASN I CA  1 
ATOM   6278 C  C   . ASN E 2 201 ? 47.548  -37.704 49.568  1.00 32.77  ? 201 ASN I C   1 
ATOM   6279 O  O   . ASN E 2 201 ? 48.373  -37.133 50.293  1.00 30.13  ? 201 ASN I O   1 
ATOM   6280 C  CB  . ASN E 2 201 ? 46.319  -38.458 51.642  1.00 35.55  ? 201 ASN I CB  1 
ATOM   6281 C  CG  . ASN E 2 201 ? 44.979  -38.805 52.274  1.00 36.98  ? 201 ASN I CG  1 
ATOM   6282 O  OD1 . ASN E 2 201 ? 44.093  -37.960 52.365  1.00 37.75  ? 201 ASN I OD1 1 
ATOM   6283 N  ND2 . ASN E 2 201 ? 44.827  -40.051 52.705  1.00 37.19  ? 201 ASN I ND2 1 
ATOM   6284 N  N   . THR E 2 202 ? 47.761  -37.914 48.277  1.00 29.10  ? 202 THR I N   1 
ATOM   6285 C  CA  . THR E 2 202 ? 49.026  -37.539 47.674  1.00 27.00  ? 202 THR I CA  1 
ATOM   6286 C  C   . THR E 2 202 ? 48.884  -36.343 46.745  1.00 29.05  ? 202 THR I C   1 
ATOM   6287 O  O   . THR E 2 202 ? 47.829  -36.124 46.129  1.00 25.95  ? 202 THR I O   1 
ATOM   6288 C  CB  . THR E 2 202 ? 49.635  -38.707 46.882  1.00 30.18  ? 202 THR I CB  1 
ATOM   6289 O  OG1 . THR E 2 202 ? 48.724  -39.108 45.859  1.00 29.16  ? 202 THR I OG1 1 
ATOM   6290 C  CG2 . THR E 2 202 ? 49.899  -39.899 47.798  1.00 31.82  ? 202 THR I CG2 1 
ATOM   6291 N  N   . LYS E 2 203 ? 49.962  -35.573 46.653  1.00 26.71  ? 203 LYS I N   1 
ATOM   6292 C  CA  . LYS E 2 203 ? 50.076  -34.515 45.662  1.00 24.15  ? 203 LYS I CA  1 
ATOM   6293 C  C   . LYS E 2 203 ? 51.501  -34.518 45.140  1.00 26.43  ? 203 LYS I C   1 
ATOM   6294 O  O   . LYS E 2 203 ? 52.465  -34.437 45.922  1.00 30.76  ? 203 LYS I O   1 
ATOM   6295 C  CB  . LYS E 2 203 ? 49.722  -33.157 46.266  1.00 24.40  ? 203 LYS I CB  1 
ATOM   6296 C  CG  . LYS E 2 203 ? 49.808  -32.009 45.267  1.00 35.07  ? 203 LYS I CG  1 
ATOM   6297 C  CD  . LYS E 2 203 ? 48.847  -30.895 45.630  1.00 46.02  ? 203 LYS I CD  1 
ATOM   6298 C  CE  . LYS E 2 203 ? 48.850  -29.795 44.583  1.00 41.41  ? 203 LYS I CE  1 
ATOM   6299 N  NZ  . LYS E 2 203 ? 47.798  -28.785 44.863  1.00 43.02  ? 203 LYS I NZ  1 
ATOM   6300 N  N   . VAL E 2 204 ? 51.648  -34.651 43.829  1.00 20.82  ? 204 VAL I N   1 
ATOM   6301 C  CA  . VAL E 2 204 ? 52.982  -34.677 43.223  1.00 23.74  ? 204 VAL I CA  1 
ATOM   6302 C  C   . VAL E 2 204 ? 53.202  -33.477 42.305  1.00 31.92  ? 204 VAL I C   1 
ATOM   6303 O  O   . VAL E 2 204 ? 52.306  -33.100 41.545  1.00 23.85  ? 204 VAL I O   1 
ATOM   6304 C  CB  . VAL E 2 204 ? 53.195  -35.984 42.418  1.00 30.32  ? 204 VAL I CB  1 
ATOM   6305 C  CG1 . VAL E 2 204 ? 54.435  -35.897 41.534  1.00 33.88  ? 204 VAL I CG1 1 
ATOM   6306 C  CG2 . VAL E 2 204 ? 53.281  -37.175 43.352  1.00 34.07  ? 204 VAL I CG2 1 
ATOM   6307 N  N   . ASP E 2 205 ? 54.387  -32.870 42.389  1.00 27.33  ? 205 ASP I N   1 
ATOM   6308 C  CA  . ASP E 2 205 ? 54.777  -31.825 41.451  1.00 29.67  ? 205 ASP I CA  1 
ATOM   6309 C  C   . ASP E 2 205 ? 55.814  -32.366 40.481  1.00 33.00  ? 205 ASP I C   1 
ATOM   6310 O  O   . ASP E 2 205 ? 56.707  -33.123 40.861  1.00 36.36  ? 205 ASP I O   1 
ATOM   6311 C  CB  . ASP E 2 205 ? 55.323  -30.588 42.170  1.00 32.10  ? 205 ASP I CB  1 
ATOM   6312 C  CG  . ASP E 2 205 ? 54.274  -29.893 43.002  1.00 39.13  ? 205 ASP I CG  1 
ATOM   6313 O  OD1 . ASP E 2 205 ? 54.556  -29.567 44.174  1.00 54.35  ? 205 ASP I OD1 1 
ATOM   6314 O  OD2 . ASP E 2 205 ? 53.162  -29.675 42.491  1.00 39.28  ? 205 ASP I OD2 1 
ATOM   6315 N  N   . LYS E 2 206 ? 55.681  -32.001 39.213  1.00 31.41  ? 206 LYS I N   1 
ATOM   6316 C  CA  . LYS E 2 206 ? 56.685  -32.380 38.229  1.00 27.72  ? 206 LYS I CA  1 
ATOM   6317 C  C   . LYS E 2 206 ? 57.022  -31.178 37.362  1.00 34.72  ? 206 LYS I C   1 
ATOM   6318 O  O   . LYS E 2 206 ? 56.172  -30.677 36.633  1.00 30.08  ? 206 LYS I O   1 
ATOM   6319 C  CB  . LYS E 2 206 ? 56.191  -33.535 37.365  1.00 27.85  ? 206 LYS I CB  1 
ATOM   6320 C  CG  . LYS E 2 206 ? 57.279  -34.179 36.530  1.00 34.27  ? 206 LYS I CG  1 
ATOM   6321 C  CD  . LYS E 2 206 ? 58.236  -34.963 37.425  1.00 37.66  ? 206 LYS I CD  1 
ATOM   6322 C  CE  . LYS E 2 206 ? 57.467  -35.987 38.254  1.00 37.82  ? 206 LYS I CE  1 
ATOM   6323 N  NZ  . LYS E 2 206 ? 58.325  -36.723 39.229  1.00 50.90  ? 206 LYS I NZ  1 
ATOM   6324 N  N   . THR E 2 207 ? 58.261  -30.712 37.450  1.00 30.86  ? 207 THR I N   1 
ATOM   6325 C  CA  . THR E 2 207 ? 58.688  -29.585 36.630  1.00 35.18  ? 207 THR I CA  1 
ATOM   6326 C  C   . THR E 2 207 ? 59.182  -30.074 35.268  1.00 35.42  ? 207 THR I C   1 
ATOM   6327 O  O   . THR E 2 207 ? 60.032  -30.962 35.193  1.00 30.80  ? 207 THR I O   1 
ATOM   6328 C  CB  . THR E 2 207 ? 59.755  -28.731 37.357  1.00 35.94  ? 207 THR I CB  1 
ATOM   6329 O  OG1 . THR E 2 207 ? 59.173  -28.175 38.546  1.00 28.74  ? 207 THR I OG1 1 
ATOM   6330 C  CG2 . THR E 2 207 ? 60.231  -27.580 36.458  1.00 34.93  ? 207 THR I CG2 1 
ATOM   6331 N  N   . VAL E 2 208 ? 58.627  -29.515 34.192  1.00 31.54  ? 208 VAL I N   1 
ATOM   6332 C  CA  . VAL E 2 208 ? 58.979  -29.954 32.841  1.00 37.21  ? 208 VAL I CA  1 
ATOM   6333 C  C   . VAL E 2 208 ? 59.726  -28.858 32.079  1.00 41.63  ? 208 VAL I C   1 
ATOM   6334 O  O   . VAL E 2 208 ? 59.272  -27.719 31.995  1.00 43.08  ? 208 VAL I O   1 
ATOM   6335 C  CB  . VAL E 2 208 ? 57.740  -30.356 32.030  1.00 33.13  ? 208 VAL I CB  1 
ATOM   6336 C  CG1 . VAL E 2 208 ? 58.157  -31.157 30.807  1.00 31.29  ? 208 VAL I CG1 1 
ATOM   6337 C  CG2 . VAL E 2 208 ? 56.781  -31.156 32.883  1.00 38.22  ? 208 VAL I CG2 1 
ATOM   6338 N  N   . ALA E 2 209 ? 60.885  -29.204 31.536  1.00 46.49  ? 209 ALA I N   1 
ATOM   6339 C  CA  . ALA E 2 209 ? 61.697  -28.243 30.799  1.00 61.08  ? 209 ALA I CA  1 
ATOM   6340 C  C   . ALA E 2 209 ? 61.628  -28.621 29.337  1.00 57.78  ? 209 ALA I C   1 
ATOM   6341 O  O   . ALA E 2 209 ? 61.570  -29.804 29.012  1.00 59.74  ? 209 ALA I O   1 
ATOM   6342 C  CB  . ALA E 2 209 ? 63.137  -28.221 31.309  1.00 68.08  ? 209 ALA I CB  1 
ATOM   6343 N  N   . PRO E 2 210 ? 61.596  -27.613 28.452  1.00 56.47  ? 210 PRO I N   1 
ATOM   6344 C  CA  . PRO E 2 210 ? 61.566  -27.883 27.014  1.00 68.67  ? 210 PRO I CA  1 
ATOM   6345 C  C   . PRO E 2 210 ? 62.696  -28.821 26.683  1.00 74.48  ? 210 PRO I C   1 
ATOM   6346 O  O   . PRO E 2 210 ? 63.777  -28.745 27.297  1.00 80.15  ? 210 PRO I O   1 
ATOM   6347 C  CB  . PRO E 2 210 ? 61.791  -26.508 26.378  1.00 66.46  ? 210 PRO I CB  1 
ATOM   6348 C  CG  . PRO E 2 210 ? 62.390  -25.688 27.465  1.00 67.22  ? 210 PRO I CG  1 
ATOM   6349 C  CD  . PRO E 2 210 ? 61.786  -26.185 28.731  1.00 61.73  ? 210 PRO I CD  1 
ATOM   6350 N  N   . SER E 2 211 ? 62.391  -29.675 25.709  1.00 68.30  ? 211 SER I N   1 
ATOM   6351 C  CA  . SER E 2 211 ? 62.939  -31.020 25.572  1.00 65.56  ? 211 SER I CA  1 
ATOM   6352 C  C   . SER E 2 211 ? 64.054  -31.402 26.582  1.00 76.36  ? 211 SER I C   1 
ATOM   6353 O  O   . SER E 2 211 ? 63.754  -32.115 27.550  1.00 65.54  ? 211 SER I O   1 
ATOM   6354 C  CB  . SER E 2 211 ? 63.191  -31.374 24.096  1.00 63.75  ? 211 SER I CB  1 
ATOM   6355 O  OG  . SER E 2 211 ? 63.547  -32.737 23.963  1.00 74.25  ? 211 SER I OG  1 
ATOM   6356 N  N   . THR E 2 212 ? 65.303  -30.948 26.423  1.00 74.47  ? 212 THR I N   1 
ATOM   6357 C  CA  . THR E 2 212 ? 65.862  -30.316 25.230  1.00 70.87  ? 212 THR I CA  1 
ATOM   6358 C  C   . THR E 2 212 ? 67.173  -31.033 25.002  1.00 75.90  ? 212 THR I C   1 
ATOM   6359 O  O   . THR E 2 212 ? 67.762  -31.536 25.955  1.00 80.14  ? 212 THR I O   1 
ATOM   6360 C  CB  . THR E 2 212 ? 66.071  -28.793 25.387  1.00 74.28  ? 212 THR I CB  1 
ATOM   6361 O  OG1 . THR E 2 212 ? 66.654  -28.258 24.192  1.00 70.48  ? 212 THR I OG1 1 
ATOM   6362 C  CG2 . THR E 2 212 ? 66.964  -28.482 26.585  1.00 79.35  ? 212 THR I CG2 1 
ATOM   6363 N  N   . CYS E 2 213 ? 67.602  -31.143 23.749  1.00 74.46  ? 213 CYS I N   1 
ATOM   6364 C  CA  . CYS E 2 213 ? 68.939  -31.652 23.453  1.00 73.71  ? 213 CYS I CA  1 
ATOM   6365 C  C   . CYS E 2 213 ? 69.593  -30.839 22.343  1.00 68.00  ? 213 CYS I C   1 
ATOM   6366 O  O   . CYS E 2 213 ? 70.590  -30.153 22.578  1.00 62.01  ? 213 CYS I O   1 
ATOM   6367 C  CB  . CYS E 2 213 ? 68.921  -33.134 23.077  1.00 67.81  ? 213 CYS I CB  1 
ATOM   6368 S  SG  . CYS E 2 213 ? 67.790  -34.173 24.049  1.00 77.99  ? 213 CYS I SG  1 
ATOM   6369 N  N   . THR F 3 3   ? 0.178   -31.627 51.764  1.00 56.99  ? 303 THR Q N   1 
ATOM   6370 C  CA  . THR F 3 3   ? 0.653   -32.911 51.252  1.00 56.61  ? 303 THR Q CA  1 
ATOM   6371 C  C   . THR F 3 3   ? 1.314   -32.762 49.882  1.00 49.10  ? 303 THR Q C   1 
ATOM   6372 O  O   . THR F 3 3   ? 0.892   -31.943 49.059  1.00 47.17  ? 303 THR Q O   1 
ATOM   6373 C  CB  . THR F 3 3   ? -0.484  -33.952 51.153  1.00 53.31  ? 303 THR Q CB  1 
ATOM   6374 O  OG1 . THR F 3 3   ? -1.309  -33.665 50.017  1.00 55.51  ? 303 THR Q OG1 1 
ATOM   6375 C  CG2 . THR F 3 3   ? -1.334  -33.937 52.414  1.00 53.41  ? 303 THR Q CG2 1 
ATOM   6376 N  N   . ARG F 3 4   ? 2.346   -33.567 49.648  1.00 40.50  ? 304 ARG Q N   1 
ATOM   6377 C  CA  . ARG F 3 4   ? 3.089   -33.545 48.390  1.00 39.39  ? 304 ARG Q CA  1 
ATOM   6378 C  C   . ARG F 3 4   ? 2.290   -34.199 47.278  1.00 28.45  ? 304 ARG Q C   1 
ATOM   6379 O  O   . ARG F 3 4   ? 1.807   -35.313 47.433  1.00 34.80  ? 304 ARG Q O   1 
ATOM   6380 C  CB  . ARG F 3 4   ? 4.426   -34.284 48.546  1.00 32.85  ? 304 ARG Q CB  1 
ATOM   6381 C  CG  . ARG F 3 4   ? 5.146   -34.539 47.221  1.00 29.07  ? 304 ARG Q CG  1 
ATOM   6382 C  CD  . ARG F 3 4   ? 6.271   -35.558 47.355  1.00 23.07  ? 304 ARG Q CD  1 
ATOM   6383 N  NE  . ARG F 3 4   ? 7.410   -35.084 48.147  1.00 22.70  ? 304 ARG Q NE  1 
ATOM   6384 C  CZ  . ARG F 3 4   ? 8.410   -34.363 47.649  1.00 20.92  ? 304 ARG Q CZ  1 
ATOM   6385 N  NH1 . ARG F 3 4   ? 8.398   -34.027 46.374  1.00 25.35  ? 304 ARG Q NH1 1 
ATOM   6386 N  NH2 . ARG F 3 4   ? 9.419   -33.983 48.418  1.00 20.15  ? 304 ARG Q NH2 1 
ATOM   6387 N  N   . LYS F 3 5   ? 2.180   -33.516 46.149  1.00 24.34  ? 305 LYS Q N   1 
ATOM   6388 C  CA  . LYS F 3 5   ? 1.499   -34.071 44.988  1.00 27.81  ? 305 LYS Q CA  1 
ATOM   6389 C  C   . LYS F 3 5   ? 2.477   -34.686 43.981  1.00 23.90  ? 305 LYS Q C   1 
ATOM   6390 O  O   . LYS F 3 5   ? 2.207   -35.745 43.414  1.00 22.34  ? 305 LYS Q O   1 
ATOM   6391 C  CB  . LYS F 3 5   ? 0.661   -32.984 44.300  1.00 34.09  ? 305 LYS Q CB  1 
ATOM   6392 C  CG  . LYS F 3 5   ? -0.302  -32.269 45.235  1.00 41.26  ? 305 LYS Q CG  1 
ATOM   6393 C  CD  . LYS F 3 5   ? -1.292  -33.245 45.850  1.00 40.71  ? 305 LYS Q CD  1 
ATOM   6394 C  CE  . LYS F 3 5   ? -1.998  -32.632 47.054  1.00 58.29  ? 305 LYS Q CE  1 
ATOM   6395 N  NZ  . LYS F 3 5   ? -2.532  -31.273 46.763  1.00 68.67  ? 305 LYS Q NZ  1 
ATOM   6396 N  N   . SER F 3 6   ? 3.607   -34.014 43.761  1.00 22.25  ? 306 SER Q N   1 
ATOM   6397 C  CA  . SER F 3 6   ? 4.553   -34.411 42.716  1.00 24.89  ? 306 SER Q CA  1 
ATOM   6398 C  C   . SER F 3 6   ? 5.975   -33.991 43.116  1.00 27.13  ? 306 SER Q C   1 
ATOM   6399 O  O   . SER F 3 6   ? 6.296   -33.958 44.301  1.00 27.24  ? 306 SER Q O   1 
ATOM   6400 C  CB  . SER F 3 6   ? 4.147   -33.772 41.376  1.00 21.48  ? 306 SER Q CB  1 
ATOM   6401 O  OG  . SER F 3 6   ? 4.915   -34.266 40.282  1.00 20.56  ? 306 SER Q OG  1 
ATOM   6402 N  N   . ILE F 3 7   ? 6.835   -33.701 42.140  1.00 18.51  ? 307 ILE Q N   1 
ATOM   6403 C  CA  . ILE F 3 7   ? 8.083   -33.011 42.434  1.00 19.60  ? 307 ILE Q CA  1 
ATOM   6404 C  C   . ILE F 3 7   ? 7.934   -31.573 41.945  1.00 19.53  ? 307 ILE Q C   1 
ATOM   6405 O  O   . ILE F 3 7   ? 7.225   -31.305 40.966  1.00 19.65  ? 307 ILE Q O   1 
ATOM   6406 C  CB  . ILE F 3 7   ? 9.322   -33.643 41.734  1.00 21.07  ? 307 ILE Q CB  1 
ATOM   6407 C  CG1 . ILE F 3 7   ? 9.072   -33.827 40.228  1.00 18.15  ? 307 ILE Q CG1 1 
ATOM   6408 C  CG2 . ILE F 3 7   ? 9.749   -34.940 42.417  1.00 24.23  ? 307 ILE Q CG2 1 
ATOM   6409 C  CD1 . ILE F 3 7   ? 10.334  -34.004 39.415  1.00 17.02  ? 307 ILE Q CD1 1 
ATOM   6410 N  N   . HIS F 3 8   ? 8.601   -30.638 42.603  1.00 23.10  ? 308 HIS Q N   1 
ATOM   6411 C  CA  . HIS F 3 8   ? 8.550   -29.260 42.135  1.00 23.56  ? 308 HIS Q CA  1 
ATOM   6412 C  C   . HIS F 3 8   ? 9.775   -28.884 41.280  1.00 21.76  ? 308 HIS Q C   1 
ATOM   6413 O  O   . HIS F 3 8   ? 10.915  -28.961 41.740  1.00 18.50  ? 308 HIS Q O   1 
ATOM   6414 C  CB  . HIS F 3 8   ? 8.373   -28.278 43.304  1.00 25.03  ? 308 HIS Q CB  1 
ATOM   6415 C  CG  . HIS F 3 8   ? 8.110   -26.872 42.855  1.00 34.86  ? 308 HIS Q CG  1 
ATOM   6416 N  ND1 . HIS F 3 8   ? 6.844   -26.410 42.562  1.00 39.96  ? 308 HIS Q ND1 1 
ATOM   6417 C  CD2 . HIS F 3 8   ? 8.954   -25.850 42.597  1.00 29.52  ? 308 HIS Q CD2 1 
ATOM   6418 C  CE1 . HIS F 3 8   ? 6.920   -25.152 42.164  1.00 38.27  ? 308 HIS Q CE1 1 
ATOM   6419 N  NE2 . HIS F 3 8   ? 8.188   -24.787 42.176  1.00 33.14  ? 308 HIS Q NE2 1 
ATOM   6420 N  N   . ILE F 3 9   ? 9.528   -28.463 40.040  1.00 21.81  ? 309 ILE Q N   1 
ATOM   6421 C  CA  . ILE F 3 9   ? 10.592  -28.064 39.120  1.00 19.93  ? 309 ILE Q CA  1 
ATOM   6422 C  C   . ILE F 3 9   ? 10.524  -26.551 38.797  1.00 24.44  ? 309 ILE Q C   1 
ATOM   6423 O  O   . ILE F 3 9   ? 9.495   -26.039 38.368  1.00 25.79  ? 309 ILE Q O   1 
ATOM   6424 C  CB  . ILE F 3 9   ? 10.517  -28.865 37.788  1.00 20.58  ? 309 ILE Q CB  1 
ATOM   6425 C  CG1 . ILE F 3 9   ? 10.465  -30.374 38.048  1.00 17.14  ? 309 ILE Q CG1 1 
ATOM   6426 C  CG2 . ILE F 3 9   ? 11.692  -28.507 36.871  1.00 20.67  ? 309 ILE Q CG2 1 
ATOM   6427 C  CD1 . ILE F 3 9   ? 10.240  -31.197 36.793  1.00 16.58  ? 309 ILE Q CD1 1 
ATOM   6428 N  N   . GLY F 3 10  ? 11.619  -25.841 39.016  1.00 21.60  ? 312 GLY Q N   1 
ATOM   6429 C  CA  . GLY F 3 10  ? 11.703  -24.446 38.628  1.00 24.74  ? 312 GLY Q CA  1 
ATOM   6430 C  C   . GLY F 3 10  ? 11.351  -23.519 39.770  1.00 29.63  ? 312 GLY Q C   1 
ATOM   6431 O  O   . GLY F 3 10  ? 11.182  -23.969 40.899  1.00 30.17  ? 312 GLY Q O   1 
ATOM   6432 N  N   . PRO F 3 11  ? 11.221  -22.215 39.475  1.00 41.85  ? 313 PRO Q N   1 
ATOM   6433 C  CA  . PRO F 3 11  ? 10.942  -21.171 40.474  1.00 39.47  ? 313 PRO Q CA  1 
ATOM   6434 C  C   . PRO F 3 11  ? 9.657   -21.451 41.245  1.00 45.12  ? 313 PRO Q C   1 
ATOM   6435 O  O   . PRO F 3 11  ? 8.690   -21.977 40.684  1.00 48.43  ? 313 PRO Q O   1 
ATOM   6436 C  CB  . PRO F 3 11  ? 10.782  -19.905 39.623  1.00 52.35  ? 313 PRO Q CB  1 
ATOM   6437 C  CG  . PRO F 3 11  ? 11.503  -20.207 38.339  1.00 49.08  ? 313 PRO Q CG  1 
ATOM   6438 C  CD  . PRO F 3 11  ? 11.284  -21.669 38.107  1.00 41.23  ? 313 PRO Q CD  1 
ATOM   6439 N  N   . GLY F 3 12  ? 9.652   -21.103 42.527  1.00 56.24  ? 314 GLY Q N   1 
ATOM   6440 C  CA  . GLY F 3 12  ? 8.508   -21.374 43.380  1.00 56.65  ? 314 GLY Q CA  1 
ATOM   6441 C  C   . GLY F 3 12  ? 7.510   -20.237 43.424  1.00 60.91  ? 314 GLY Q C   1 
ATOM   6442 O  O   . GLY F 3 12  ? 6.655   -20.196 44.307  1.00 65.17  ? 314 GLY Q O   1 
HETATM 6443 CA CA  . CA  G 4 .   ? -15.930 6.562   5.165   1.00 21.88  ? 301 CA  L CA  1 
HETATM 6444 CA CA  . CA  H 4 .   ? -13.556 8.791   22.959  1.00 39.28  ? 302 CA  L CA  1 
HETATM 6445 CA CA  . CA  I 4 .   ? -22.710 7.800   -6.912  1.00 28.29  ? 301 CA  H CA  1 
HETATM 6446 CA CA  . CA  J 4 .   ? 15.069  -41.758 37.032  1.00 19.29  ? 301 CA  M CA  1 
HETATM 6447 CA CA  . CA  K 4 .   ? 8.190   -42.993 49.092  1.00 27.62  ? 301 CA  I CA  1 
HETATM 6448 O  O   . HOH L 5 .   ? -8.699  -4.776  32.300  1.00 13.46  ? 401 HOH L O   1 
HETATM 6449 O  O   . HOH L 5 .   ? -13.847 0.286   26.076  1.00 18.33  ? 402 HOH L O   1 
HETATM 6450 O  O   . HOH L 5 .   ? -22.740 -4.881  16.033  1.00 17.19  ? 403 HOH L O   1 
HETATM 6451 O  O   . HOH L 5 .   ? -12.170 5.647   9.881   1.00 17.16  ? 404 HOH L O   1 
HETATM 6452 O  O   . HOH L 5 .   ? -19.356 8.080   2.250   1.00 20.99  ? 405 HOH L O   1 
HETATM 6453 O  O   . HOH L 5 .   ? 7.684   2.973   25.984  1.00 22.17  ? 406 HOH L O   1 
HETATM 6454 O  O   . HOH L 5 .   ? -18.397 8.306   9.683   1.00 18.61  ? 407 HOH L O   1 
HETATM 6455 O  O   . HOH L 5 .   ? -1.143  -1.669  21.137  1.00 20.54  ? 408 HOH L O   1 
HETATM 6456 O  O   . HOH L 5 .   ? 13.744  -7.734  28.228  1.00 23.06  ? 409 HOH L O   1 
HETATM 6457 O  O   . HOH L 5 .   ? -13.252 6.927   16.949  1.00 19.98  ? 410 HOH L O   1 
HETATM 6458 O  O   . HOH L 5 .   ? -21.468 8.983   4.253   1.00 21.37  ? 411 HOH L O   1 
HETATM 6459 O  O   . HOH L 5 .   ? -6.732  -11.009 17.447  1.00 20.77  ? 412 HOH L O   1 
HETATM 6460 O  O   . HOH L 5 .   ? -13.885 -13.035 29.012  1.00 24.86  ? 413 HOH L O   1 
HETATM 6461 O  O   . HOH L 5 .   ? 0.516   -2.666  19.048  1.00 24.73  ? 414 HOH L O   1 
HETATM 6462 O  O   . HOH L 5 .   ? -3.245  -0.866  19.738  1.00 23.25  ? 415 HOH L O   1 
HETATM 6463 O  O   . HOH L 5 .   ? -1.921  -13.256 25.625  1.00 23.85  ? 416 HOH L O   1 
HETATM 6464 O  O   . HOH L 5 .   ? -1.684  -13.486 22.353  1.00 23.33  ? 417 HOH L O   1 
HETATM 6465 O  O   . HOH L 5 .   ? -20.438 5.832   19.797  1.00 22.86  ? 418 HOH L O   1 
HETATM 6466 O  O   . HOH L 5 .   ? -23.363 -6.831  6.899   1.00 24.23  ? 419 HOH L O   1 
HETATM 6467 O  O   . HOH L 5 .   ? -21.836 -12.059 17.407  1.00 22.76  ? 420 HOH L O   1 
HETATM 6468 O  O   . HOH L 5 .   ? -11.531 4.189   27.059  1.00 21.97  ? 421 HOH L O   1 
HETATM 6469 O  O   . HOH L 5 .   ? 7.153   -5.707  19.725  1.00 27.42  ? 422 HOH L O   1 
HETATM 6470 O  O   . HOH L 5 .   ? -0.921  -4.107  17.150  1.00 24.50  ? 423 HOH L O   1 
HETATM 6471 O  O   . HOH L 5 .   ? -19.245 9.655   7.364   1.00 24.85  ? 424 HOH L O   1 
HETATM 6472 O  O   . HOH L 5 .   ? 24.750  5.533   15.468  1.00 25.05  ? 425 HOH L O   1 
HETATM 6473 O  O   . HOH L 5 .   ? -18.581 8.350   5.113   1.00 24.14  ? 426 HOH L O   1 
HETATM 6474 O  O   . HOH L 5 .   ? -4.904  -6.671  10.263  1.00 26.96  ? 427 HOH L O   1 
HETATM 6475 O  O   . HOH L 5 .   ? 8.940   -7.594  21.713  1.00 24.68  ? 428 HOH L O   1 
HETATM 6476 O  O   . HOH L 5 .   ? -5.633  1.721   11.920  1.00 27.61  ? 429 HOH L O   1 
HETATM 6477 O  O   . HOH L 5 .   ? -8.449  -9.446  5.580   1.00 26.25  ? 430 HOH L O   1 
HETATM 6478 O  O   . HOH L 5 .   ? 2.367   0.983   29.339  1.00 27.40  ? 431 HOH L O   1 
HETATM 6479 O  O   . HOH L 5 .   ? -27.595 6.807   2.678   1.00 25.62  ? 432 HOH L O   1 
HETATM 6480 O  O   . HOH L 5 .   ? -22.967 9.613   14.274  1.00 26.25  ? 433 HOH L O   1 
HETATM 6481 O  O   . HOH L 5 .   ? 15.913  -8.172  26.550  1.00 27.59  ? 434 HOH L O   1 
HETATM 6482 O  O   . HOH L 5 .   ? 17.570  12.400  16.433  1.00 24.96  ? 435 HOH L O   1 
HETATM 6483 O  O   . HOH L 5 .   ? -27.442 10.976  8.296   1.00 29.02  ? 436 HOH L O   1 
HETATM 6484 O  O   . HOH L 5 .   ? -8.153  6.380   17.627  1.00 27.07  ? 437 HOH L O   1 
HETATM 6485 O  O   . HOH L 5 .   ? -29.785 4.269   5.391   1.00 29.61  ? 438 HOH L O   1 
HETATM 6486 O  O   . HOH L 5 .   ? 25.918  4.626   12.877  1.00 29.07  ? 439 HOH L O   1 
HETATM 6487 O  O   . HOH L 5 .   ? -17.617 -11.553 23.684  1.00 27.87  ? 440 HOH L O   1 
HETATM 6488 O  O   . HOH L 5 .   ? 4.279   -9.957  17.110  1.00 29.84  ? 441 HOH L O   1 
HETATM 6489 O  O   . HOH L 5 .   ? 28.347  0.668   22.608  1.00 28.60  ? 442 HOH L O   1 
HETATM 6490 O  O   . HOH L 5 .   ? -27.371 -6.696  6.006   1.00 33.85  ? 443 HOH L O   1 
HETATM 6491 O  O   . HOH L 5 .   ? 14.203  6.839   16.809  1.00 32.63  ? 444 HOH L O   1 
HETATM 6492 O  O   . HOH L 5 .   ? 0.516   0.797   21.506  1.00 29.81  ? 445 HOH L O   1 
HETATM 6493 O  O   . HOH L 5 .   ? 11.896  -8.629  33.961  1.00 29.69  ? 446 HOH L O   1 
HETATM 6494 O  O   . HOH L 5 .   ? -17.038 9.602   11.882  1.00 29.17  ? 447 HOH L O   1 
HETATM 6495 O  O   . HOH L 5 .   ? -0.666  -7.763  18.945  1.00 32.59  ? 448 HOH L O   1 
HETATM 6496 O  O   . HOH L 5 .   ? 10.737  9.334   26.761  1.00 32.32  ? 449 HOH L O   1 
HETATM 6497 O  O   . HOH L 5 .   ? 3.239   0.796   19.482  1.00 29.98  ? 450 HOH L O   1 
HETATM 6498 O  O   . HOH L 5 .   ? 4.346   -9.984  29.356  1.00 31.49  ? 451 HOH L O   1 
HETATM 6499 O  O   . HOH L 5 .   ? -2.173  -1.296  7.540   1.00 30.87  ? 452 HOH L O   1 
HETATM 6500 O  O   . HOH L 5 .   ? -21.232 -6.843  22.159  1.00 33.53  ? 453 HOH L O   1 
HETATM 6501 O  O   . HOH L 5 .   ? -10.014 8.387   13.033  1.00 32.73  ? 454 HOH L O   1 
HETATM 6502 O  O   . HOH L 5 .   ? -1.774  0.984   29.500  1.00 32.33  ? 455 HOH L O   1 
HETATM 6503 O  O   . HOH L 5 .   ? -29.340 8.373   15.279  1.00 31.90  ? 456 HOH L O   1 
HETATM 6504 O  O   . HOH L 5 .   ? 16.996  -4.983  32.581  1.00 36.04  ? 457 HOH L O   1 
HETATM 6505 O  O   . HOH L 5 .   ? 15.288  8.064   31.787  1.00 32.62  ? 458 HOH L O   1 
HETATM 6506 O  O   . HOH L 5 .   ? -2.704  -4.834  34.382  1.00 35.42  ? 459 HOH L O   1 
HETATM 6507 O  O   . HOH L 5 .   ? -25.289 9.562   16.137  1.00 37.61  ? 460 HOH L O   1 
HETATM 6508 O  O   . HOH L 5 .   ? -21.401 8.036   20.452  1.00 38.82  ? 461 HOH L O   1 
HETATM 6509 O  O   . HOH L 5 .   ? -25.993 7.663   -3.224  1.00 36.41  ? 462 HOH L O   1 
HETATM 6510 O  O   . HOH L 5 .   ? -20.039 -13.833 17.851  1.00 34.07  ? 463 HOH L O   1 
HETATM 6511 O  O   . HOH L 5 .   ? -12.072 8.468   10.038  1.00 32.43  ? 464 HOH L O   1 
HETATM 6512 O  O   . HOH L 5 .   ? -17.745 -15.772 6.422   1.00 32.44  ? 465 HOH L O   1 
HETATM 6513 O  O   . HOH L 5 .   ? -23.788 12.420  13.440  1.00 36.79  ? 466 HOH L O   1 
HETATM 6514 O  O   . HOH L 5 .   ? -4.609  -2.697  36.166  1.00 32.35  ? 467 HOH L O   1 
HETATM 6515 O  O   . HOH L 5 .   ? 21.053  18.364  22.229  1.00 31.51  ? 468 HOH L O   1 
HETATM 6516 O  O   . HOH L 5 .   ? 10.458  -10.009 21.144  1.00 42.74  ? 469 HOH L O   1 
HETATM 6517 O  O   . HOH L 5 .   ? 16.825  13.600  27.469  1.00 32.24  ? 470 HOH L O   1 
HETATM 6518 O  O   . HOH L 5 .   ? 4.305   1.020   15.754  1.00 36.36  ? 471 HOH L O   1 
HETATM 6519 O  O   . HOH L 5 .   ? -28.553 10.868  4.252   1.00 36.05  ? 472 HOH L O   1 
HETATM 6520 O  O   . HOH L 5 .   ? 6.177   -12.161 29.684  1.00 34.69  ? 473 HOH L O   1 
HETATM 6521 O  O   . HOH L 5 .   ? 7.877   -7.761  18.506  1.00 32.67  ? 474 HOH L O   1 
HETATM 6522 O  O   . HOH L 5 .   ? 12.770  10.789  25.220  1.00 43.72  ? 475 HOH L O   1 
HETATM 6523 O  O   . HOH L 5 .   ? -28.446 -5.927  3.853   1.00 39.27  ? 476 HOH L O   1 
HETATM 6524 O  O   . HOH L 5 .   ? 13.284  -10.479 28.678  1.00 34.54  ? 477 HOH L O   1 
HETATM 6525 O  O   . HOH L 5 .   ? 13.917  16.573  20.788  1.00 35.70  ? 478 HOH L O   1 
HETATM 6526 O  O   . HOH L 5 .   ? -2.287  -7.601  33.337  1.00 38.16  ? 479 HOH L O   1 
HETATM 6527 O  O   . HOH L 5 .   ? 25.452  -1.929  21.121  1.00 35.85  ? 480 HOH L O   1 
HETATM 6528 O  O   . HOH L 5 .   ? 20.007  -5.108  32.228  1.00 39.29  ? 481 HOH L O   1 
HETATM 6529 O  O   . HOH L 5 .   ? -33.334 -0.007  4.920   1.00 35.79  ? 482 HOH L O   1 
HETATM 6530 O  O   . HOH L 5 .   ? 11.871  -2.066  35.761  1.00 34.52  ? 483 HOH L O   1 
HETATM 6531 O  O   . HOH L 5 .   ? -3.954  -9.937  33.693  1.00 37.92  ? 484 HOH L O   1 
HETATM 6532 O  O   . HOH L 5 .   ? 8.804   -4.566  34.614  1.00 36.07  ? 485 HOH L O   1 
HETATM 6533 O  O   . HOH L 5 .   ? 8.894   -6.038  16.720  1.00 37.33  ? 486 HOH L O   1 
HETATM 6534 O  O   . HOH L 5 .   ? -15.097 9.358   18.326  1.00 40.97  ? 487 HOH L O   1 
HETATM 6535 O  O   . HOH L 5 .   ? 7.890   5.621   25.117  1.00 36.14  ? 488 HOH L O   1 
HETATM 6536 O  O   . HOH L 5 .   ? -0.966  2.611   27.702  1.00 40.35  ? 489 HOH L O   1 
HETATM 6537 O  O   . HOH L 5 .   ? -23.807 10.111  17.665  1.00 39.89  ? 490 HOH L O   1 
HETATM 6538 O  O   . HOH L 5 .   ? -24.856 -9.207  4.238   1.00 40.40  ? 491 HOH L O   1 
HETATM 6539 O  O   . HOH L 5 .   ? 10.627  -8.584  18.200  1.00 40.52  ? 492 HOH L O   1 
HETATM 6540 O  O   . HOH L 5 .   ? 1.106   -6.330  16.558  1.00 37.83  ? 493 HOH L O   1 
HETATM 6541 O  O   . HOH L 5 .   ? -24.834 10.013  -2.682  1.00 40.94  ? 494 HOH L O   1 
HETATM 6542 O  O   . HOH L 5 .   ? -0.707  -13.340 14.925  1.00 40.96  ? 495 HOH L O   1 
HETATM 6543 O  O   . HOH L 5 .   ? -30.427 11.720  9.152   1.00 41.76  ? 496 HOH L O   1 
HETATM 6544 O  O   . HOH L 5 .   ? 9.814   -6.603  36.196  1.00 41.43  ? 497 HOH L O   1 
HETATM 6545 O  O   . HOH L 5 .   ? -28.173 -10.240 5.359   1.00 45.05  ? 498 HOH L O   1 
HETATM 6546 O  O   . HOH L 5 .   ? 22.184  -4.690  26.724  1.00 44.85  ? 499 HOH L O   1 
HETATM 6547 O  O   . HOH L 5 .   ? 20.717  18.849  18.406  1.00 39.19  ? 500 HOH L O   1 
HETATM 6548 O  O   . HOH L 5 .   ? 32.790  7.871   17.502  1.00 42.82  ? 501 HOH L O   1 
HETATM 6549 O  O   . HOH L 5 .   ? -32.593 1.770   6.235   1.00 39.99  ? 502 HOH L O   1 
HETATM 6550 O  O   . HOH L 5 .   ? 0.959   -8.671  16.023  1.00 42.09  ? 503 HOH L O   1 
HETATM 6551 O  O   . HOH L 5 .   ? 14.349  -1.552  34.311  1.00 40.38  ? 504 HOH L O   1 
HETATM 6552 O  O   . HOH L 5 .   ? 9.560   11.314  18.319  1.00 40.17  ? 505 HOH L O   1 
HETATM 6553 O  O   . HOH L 5 .   ? -30.391 -6.632  3.006   1.00 44.16  ? 506 HOH L O   1 
HETATM 6554 O  O   . HOH L 5 .   ? 31.149  2.876   7.689   1.00 43.72  ? 507 HOH L O   1 
HETATM 6555 O  O   . HOH L 5 .   ? 3.735   1.176   13.382  1.00 44.89  ? 508 HOH L O   1 
HETATM 6556 O  O   . HOH L 5 .   ? 21.573  18.487  33.168  1.00 38.14  ? 509 HOH L O   1 
HETATM 6557 O  O   . HOH L 5 .   ? 27.751  23.524  15.762  1.00 39.18  ? 510 HOH L O   1 
HETATM 6558 O  O   . HOH L 5 .   ? 29.389  20.997  12.156  1.00 43.61  ? 511 HOH L O   1 
HETATM 6559 O  O   . HOH L 5 .   ? -2.675  -11.398 13.814  1.00 44.48  ? 512 HOH L O   1 
HETATM 6560 O  O   . HOH L 5 .   ? 1.081   0.194   17.430  1.00 34.82  ? 513 HOH L O   1 
HETATM 6561 O  O   . HOH L 5 .   ? 8.074   -12.614 27.932  1.00 38.15  ? 514 HOH L O   1 
HETATM 6562 O  O   . HOH L 5 .   ? -25.362 -12.718 5.014   1.00 39.79  ? 515 HOH L O   1 
HETATM 6563 O  O   . HOH L 5 .   ? 36.463  6.316   30.771  1.00 41.74  ? 516 HOH L O   1 
HETATM 6564 O  O   . HOH L 5 .   ? 10.897  15.761  14.150  1.00 39.94  ? 517 HOH L O   1 
HETATM 6565 O  O   . HOH L 5 .   ? 15.852  5.287   37.980  1.00 31.10  ? 518 HOH L O   1 
HETATM 6566 O  O   . HOH L 5 .   ? 27.382  5.044   32.654  1.00 46.01  ? 519 HOH L O   1 
HETATM 6567 O  O   . HOH L 5 .   ? 4.737   3.070   32.515  1.00 38.66  ? 520 HOH L O   1 
HETATM 6568 O  O   . HOH L 5 .   ? 17.076  -10.435 28.318  1.00 42.90  ? 521 HOH L O   1 
HETATM 6569 O  O   . HOH L 5 .   ? -21.506 11.517  3.398   1.00 35.43  ? 522 HOH L O   1 
HETATM 6570 O  O   . HOH L 5 .   ? 9.407   -11.809 22.950  1.00 42.92  ? 523 HOH L O   1 
HETATM 6571 O  O   . HOH L 5 .   ? -6.031  -4.805  37.917  1.00 32.26  ? 524 HOH L O   1 
HETATM 6572 O  O   . HOH L 5 .   ? -3.105  -13.082 32.897  1.00 38.17  ? 525 HOH L O   1 
HETATM 6573 O  O   . HOH L 5 .   ? -0.743  -11.825 31.688  1.00 42.26  ? 526 HOH L O   1 
HETATM 6574 O  O   . HOH L 5 .   ? -30.335 -13.248 7.695   1.00 53.81  ? 527 HOH L O   1 
HETATM 6575 O  O   . HOH L 5 .   ? 20.766  -4.227  29.502  1.00 22.44  ? 528 HOH L O   1 
HETATM 6576 O  O   . HOH L 5 .   ? -18.595 -13.956 22.996  1.00 39.01  ? 529 HOH L O   1 
HETATM 6577 O  O   . HOH L 5 .   ? -16.119 8.012   14.504  1.00 24.80  ? 530 HOH L O   1 
HETATM 6578 O  O   . HOH L 5 .   ? 14.639  18.739  17.874  1.00 41.25  ? 531 HOH L O   1 
HETATM 6579 O  O   . HOH L 5 .   ? 15.021  -4.729  20.634  1.00 35.78  ? 532 HOH L O   1 
HETATM 6580 O  O   . HOH L 5 .   ? 8.374   10.149  23.014  1.00 44.21  ? 533 HOH L O   1 
HETATM 6581 O  O   . HOH L 5 .   ? -22.359 -16.194 14.101  1.00 31.42  ? 534 HOH L O   1 
HETATM 6582 O  O   . HOH L 5 .   ? -34.422 1.028   8.038   1.00 43.31  ? 535 HOH L O   1 
HETATM 6583 O  O   . HOH L 5 .   ? -27.188 -13.876 14.072  1.00 49.92  ? 536 HOH L O   1 
HETATM 6584 O  O   . HOH L 5 .   ? 25.410  -1.352  24.313  1.00 29.75  ? 537 HOH L O   1 
HETATM 6585 O  O   . HOH L 5 .   ? 24.900  19.778  25.319  1.00 47.66  ? 538 HOH L O   1 
HETATM 6586 O  O   . HOH L 5 .   ? -11.523 -14.479 31.342  1.00 43.78  ? 539 HOH L O   1 
HETATM 6587 O  O   . HOH L 5 .   ? -15.944 -18.691 13.282  1.00 34.92  ? 540 HOH L O   1 
HETATM 6588 O  O   . HOH L 5 .   ? -22.695 -9.215  23.655  1.00 46.49  ? 541 HOH L O   1 
HETATM 6589 O  O   . HOH L 5 .   ? -21.421 13.384  5.919   1.00 44.50  ? 542 HOH L O   1 
HETATM 6590 O  O   . HOH L 5 .   ? -28.672 -9.947  11.905  1.00 39.15  ? 543 HOH L O   1 
HETATM 6591 O  O   . HOH L 5 .   ? 6.030   -6.445  16.681  1.00 40.70  ? 544 HOH L O   1 
HETATM 6592 O  O   . HOH L 5 .   ? 38.880  2.065   16.849  1.00 38.35  ? 545 HOH L O   1 
HETATM 6593 O  O   . HOH L 5 .   ? 4.650   5.772   23.706  1.00 39.27  ? 546 HOH L O   1 
HETATM 6594 O  O   . HOH L 5 .   ? 7.446   7.079   22.944  1.00 48.26  ? 547 HOH L O   1 
HETATM 6595 O  O   . HOH L 5 .   ? 37.116  2.488   15.486  1.00 43.34  ? 548 HOH L O   1 
HETATM 6596 O  O   . HOH L 5 .   ? 10.377  -12.790 28.912  1.00 36.71  ? 549 HOH L O   1 
HETATM 6597 O  O   . HOH L 5 .   ? -10.562 7.481   24.219  1.00 31.51  ? 550 HOH L O   1 
HETATM 6598 O  O   . HOH L 5 .   ? 1.338   2.012   25.972  1.00 33.63  ? 551 HOH L O   1 
HETATM 6599 O  O   . HOH L 5 .   ? -25.011 12.205  3.069   1.00 39.60  ? 552 HOH L O   1 
HETATM 6600 O  O   . HOH L 5 .   ? -21.649 -16.714 17.180  1.00 54.25  ? 553 HOH L O   1 
HETATM 6601 O  O   . HOH L 5 .   ? -7.904  -16.967 14.344  1.00 45.48  ? 554 HOH L O   1 
HETATM 6602 O  O   . HOH L 5 .   ? 3.168   -2.558  4.417   1.00 49.70  ? 555 HOH L O   1 
HETATM 6603 O  O   . HOH L 5 .   ? -35.378 3.155   -3.170  1.00 34.31  ? 556 HOH L O   1 
HETATM 6604 O  O   . HOH L 5 .   ? -35.483 4.773   -5.529  1.00 43.88  ? 557 HOH L O   1 
HETATM 6605 O  O   . HOH L 5 .   ? 34.355  8.987   5.484   1.00 46.44  ? 558 HOH L O   1 
HETATM 6606 O  O   . HOH L 5 .   ? -3.398  -0.296  13.236  1.00 41.26  ? 559 HOH L O   1 
HETATM 6607 O  O   . HOH L 5 .   ? 30.165  0.873   13.513  1.00 47.69  ? 560 HOH L O   1 
HETATM 6608 O  O   . HOH L 5 .   ? 9.396   -11.129 33.155  1.00 47.00  ? 561 HOH L O   1 
HETATM 6609 O  O   . HOH L 5 .   ? -25.002 6.179   -4.720  1.00 38.57  ? 562 HOH L O   1 
HETATM 6610 O  O   . HOH L 5 .   ? 8.119   -4.566  14.543  1.00 48.40  ? 563 HOH L O   1 
HETATM 6611 O  O   . HOH L 5 .   ? 28.706  0.339   25.408  1.00 45.54  ? 564 HOH L O   1 
HETATM 6612 O  O   . HOH L 5 .   ? 30.507  -1.694  12.003  1.00 46.50  ? 565 HOH L O   1 
HETATM 6613 O  O   . HOH L 5 .   ? 20.208  21.183  25.948  1.00 55.42  ? 566 HOH L O   1 
HETATM 6614 O  O   . HOH L 5 .   ? 1.707   -11.457 29.434  1.00 39.94  ? 567 HOH L O   1 
HETATM 6615 O  O   . HOH L 5 .   ? -3.514  3.527   26.227  1.00 43.95  ? 568 HOH L O   1 
HETATM 6616 O  O   . HOH L 5 .   ? -6.891  8.582   21.340  1.00 42.37  ? 569 HOH L O   1 
HETATM 6617 O  O   . HOH L 5 .   ? 1.752   4.049   28.981  1.00 42.51  ? 570 HOH L O   1 
HETATM 6618 O  O   . HOH L 5 .   ? -12.758 10.433  11.834  1.00 45.81  ? 571 HOH L O   1 
HETATM 6619 O  O   . HOH L 5 .   ? -11.989 -12.610 7.706   1.00 34.77  ? 572 HOH L O   1 
HETATM 6620 O  O   . HOH L 5 .   ? -34.460 -1.632  14.926  1.00 41.46  ? 573 HOH L O   1 
HETATM 6621 O  O   . HOH L 5 .   ? 27.895  1.829   15.422  1.00 34.91  ? 574 HOH L O   1 
HETATM 6622 O  O   . HOH L 5 .   ? 2.348   -6.103  14.421  1.00 35.23  ? 575 HOH L O   1 
HETATM 6623 O  O   . HOH L 5 .   ? -14.593 8.337   9.772   1.00 41.58  ? 576 HOH L O   1 
HETATM 6624 O  O   . HOH L 5 .   ? 2.159   -5.112  12.713  1.00 42.48  ? 577 HOH L O   1 
HETATM 6625 O  O   . HOH L 5 .   ? -26.881 -1.815  21.188  1.00 40.26  ? 578 HOH L O   1 
HETATM 6626 O  O   . HOH L 5 .   ? 7.002   -2.500  36.345  1.00 43.90  ? 579 HOH L O   1 
HETATM 6627 O  O   . HOH L 5 .   ? -32.363 9.886   9.277   1.00 50.57  ? 580 HOH L O   1 
HETATM 6628 O  O   . HOH L 5 .   ? -11.872 9.346   16.739  1.00 47.53  ? 581 HOH L O   1 
HETATM 6629 O  O   . HOH L 5 .   ? -24.285 13.015  6.649   1.00 36.52  ? 582 HOH L O   1 
HETATM 6630 O  O   . HOH L 5 .   ? -7.637  5.527   13.648  1.00 40.35  ? 583 HOH L O   1 
HETATM 6631 O  O   . HOH L 5 .   ? 7.815   4.298   33.500  1.00 43.57  ? 584 HOH L O   1 
HETATM 6632 O  O   . HOH L 5 .   ? 3.884   -2.764  36.453  1.00 42.03  ? 585 HOH L O   1 
HETATM 6633 O  O   . HOH L 5 .   ? 7.314   -0.522  36.307  1.00 44.55  ? 586 HOH L O   1 
HETATM 6634 O  O   . HOH L 5 .   ? 28.204  19.681  3.927   1.00 52.91  ? 587 HOH L O   1 
HETATM 6635 O  O   . HOH L 5 .   ? 9.672   12.101  20.879  1.00 49.17  ? 588 HOH L O   1 
HETATM 6636 O  O   . HOH L 5 .   ? 19.491  -8.168  32.469  1.00 44.54  ? 589 HOH L O   1 
HETATM 6637 O  O   . HOH L 5 .   ? 28.972  19.646  5.733   1.00 53.88  ? 590 HOH L O   1 
HETATM 6638 O  O   . HOH L 5 .   ? -26.609 4.303   -6.058  1.00 30.89  ? 591 HOH L O   1 
HETATM 6639 O  O   . HOH L 5 .   ? 0.374   -0.035  31.177  1.00 40.07  ? 592 HOH L O   1 
HETATM 6640 O  O   . HOH L 5 .   ? 9.216   6.126   33.476  1.00 44.52  ? 593 HOH L O   1 
HETATM 6641 O  O   . HOH L 5 .   ? -29.302 -8.724  13.565  1.00 44.94  ? 594 HOH L O   1 
HETATM 6642 O  O   . HOH L 5 .   ? 18.879  7.756   38.240  1.00 49.56  ? 595 HOH L O   1 
HETATM 6643 O  O   . HOH L 5 .   ? -32.883 6.661   9.831   1.00 42.31  ? 596 HOH L O   1 
HETATM 6644 O  O   . HOH L 5 .   ? 0.765   -2.089  33.309  1.00 36.51  ? 597 HOH L O   1 
HETATM 6645 O  O   . HOH L 5 .   ? 22.260  20.401  16.394  1.00 51.39  ? 598 HOH L O   1 
HETATM 6646 O  O   . HOH M 5 .   ? 28.458  3.608   5.488   1.00 40.26  ? 401 HOH H O   1 
HETATM 6647 O  O   . HOH M 5 .   ? -16.784 3.827   -14.291 1.00 13.45  ? 402 HOH H O   1 
HETATM 6648 O  O   . HOH M 5 .   ? -17.497 9.486   -10.097 1.00 12.77  ? 403 HOH H O   1 
HETATM 6649 O  O   . HOH M 5 .   ? -15.739 -4.709  -1.252  1.00 16.10  ? 404 HOH H O   1 
HETATM 6650 O  O   . HOH M 5 .   ? -11.664 3.684   -13.658 1.00 18.41  ? 405 HOH H O   1 
HETATM 6651 O  O   . HOH M 5 .   ? -3.377  -10.811 -7.695  1.00 19.59  ? 406 HOH H O   1 
HETATM 6652 O  O   . HOH M 5 .   ? -16.922 -0.969  -15.086 1.00 21.59  ? 407 HOH H O   1 
HETATM 6653 O  O   . HOH M 5 .   ? -16.360 8.232   2.403   1.00 21.91  ? 408 HOH H O   1 
HETATM 6654 O  O   . HOH M 5 .   ? -22.824 6.495   -2.399  1.00 19.79  ? 409 HOH H O   1 
HETATM 6655 O  O   . HOH M 5 .   ? -7.754  8.411   6.182   1.00 21.60  ? 410 HOH H O   1 
HETATM 6656 O  O   . HOH M 5 .   ? -7.872  -10.563 2.885   1.00 22.06  ? 411 HOH H O   1 
HETATM 6657 O  O   . HOH M 5 .   ? -6.139  10.414  1.885   1.00 24.61  ? 412 HOH H O   1 
HETATM 6658 O  O   . HOH M 5 .   ? -11.187 -10.379 5.924   1.00 22.03  ? 413 HOH H O   1 
HETATM 6659 O  O   . HOH M 5 .   ? -2.376  1.995   5.557   1.00 24.83  ? 414 HOH H O   1 
HETATM 6660 O  O   . HOH M 5 .   ? -3.353  12.671  3.157   1.00 25.37  ? 415 HOH H O   1 
HETATM 6661 O  O   . HOH M 5 .   ? -5.916  -10.993 -0.934  1.00 24.81  ? 416 HOH H O   1 
HETATM 6662 O  O   . HOH M 5 .   ? -5.345  15.688  -12.937 1.00 26.09  ? 417 HOH H O   1 
HETATM 6663 O  O   . HOH M 5 .   ? -8.053  9.708   3.793   1.00 22.53  ? 418 HOH H O   1 
HETATM 6664 O  O   . HOH M 5 .   ? -0.815  13.838  -14.486 1.00 26.27  ? 419 HOH H O   1 
HETATM 6665 O  O   . HOH M 5 .   ? -2.383  -4.845  -9.716  1.00 26.28  ? 420 HOH H O   1 
HETATM 6666 O  O   . HOH M 5 .   ? -18.619 12.427  1.474   1.00 27.01  ? 421 HOH H O   1 
HETATM 6667 O  O   . HOH M 5 .   ? -2.347  -11.986 -5.192  1.00 25.62  ? 422 HOH H O   1 
HETATM 6668 O  O   . HOH M 5 .   ? -1.668  6.441   -14.028 1.00 29.16  ? 423 HOH H O   1 
HETATM 6669 O  O   . HOH M 5 .   ? 3.199   0.823   -2.684  1.00 27.50  ? 424 HOH H O   1 
HETATM 6670 O  O   . HOH M 5 .   ? 10.434  5.224   -1.858  1.00 28.01  ? 425 HOH H O   1 
HETATM 6671 O  O   . HOH M 5 .   ? 8.023   -1.744  13.805  1.00 25.73  ? 426 HOH H O   1 
HETATM 6672 O  O   . HOH M 5 .   ? -9.889  14.313  -0.397  1.00 33.99  ? 427 HOH H O   1 
HETATM 6673 O  O   . HOH M 5 .   ? 6.365   10.281  2.584   1.00 27.10  ? 428 HOH H O   1 
HETATM 6674 O  O   . HOH M 5 .   ? -22.296 9.767   -4.403  1.00 29.22  ? 429 HOH H O   1 
HETATM 6675 O  O   . HOH M 5 .   ? 9.555   0.465   9.234   1.00 27.96  ? 430 HOH H O   1 
HETATM 6676 O  O   . HOH M 5 .   ? 8.033   2.894   8.657   1.00 29.60  ? 431 HOH H O   1 
HETATM 6677 O  O   . HOH M 5 .   ? -9.297  2.766   -16.305 1.00 26.09  ? 432 HOH H O   1 
HETATM 6678 O  O   . HOH M 5 .   ? -11.833 10.716  -13.039 1.00 30.78  ? 433 HOH H O   1 
HETATM 6679 O  O   . HOH M 5 .   ? 5.479   -1.375  12.408  1.00 32.73  ? 434 HOH H O   1 
HETATM 6680 O  O   . HOH M 5 .   ? -1.249  -9.796  -8.954  1.00 27.79  ? 435 HOH H O   1 
HETATM 6681 O  O   . HOH M 5 .   ? -2.608  1.012   -12.608 1.00 31.93  ? 436 HOH H O   1 
HETATM 6682 O  O   . HOH M 5 .   ? 11.238  -2.923  5.877   1.00 28.71  ? 437 HOH H O   1 
HETATM 6683 O  O   . HOH M 5 .   ? -4.956  -10.987 2.616   1.00 32.70  ? 438 HOH H O   1 
HETATM 6684 O  O   . HOH M 5 .   ? -0.353  -4.583  3.723   1.00 33.29  ? 439 HOH H O   1 
HETATM 6685 O  O   . HOH M 5 .   ? -14.983 10.948  4.603   1.00 29.13  ? 440 HOH H O   1 
HETATM 6686 O  O   . HOH M 5 .   ? -4.220  8.303   -14.949 1.00 31.53  ? 441 HOH H O   1 
HETATM 6687 O  O   . HOH M 5 .   ? -23.928 -4.281  -3.763  1.00 32.08  ? 442 HOH H O   1 
HETATM 6688 O  O   . HOH M 5 .   ? -7.794  16.437  -2.783  1.00 32.01  ? 443 HOH H O   1 
HETATM 6689 O  O   . HOH M 5 .   ? -12.752 -17.111 -4.588  1.00 30.93  ? 444 HOH H O   1 
HETATM 6690 O  O   . HOH M 5 .   ? 2.791   -0.636  -8.459  1.00 32.50  ? 445 HOH H O   1 
HETATM 6691 O  O   . HOH M 5 .   ? 18.851  2.850   -1.152  1.00 34.62  ? 446 HOH H O   1 
HETATM 6692 O  O   . HOH M 5 .   ? -26.981 11.952  -8.504  1.00 32.84  ? 447 HOH H O   1 
HETATM 6693 O  O   . HOH M 5 .   ? 9.765   4.698   5.704   1.00 31.88  ? 448 HOH H O   1 
HETATM 6694 O  O   . HOH M 5 .   ? 1.542   14.586  1.126   1.00 33.26  ? 449 HOH H O   1 
HETATM 6695 O  O   . HOH M 5 .   ? -0.458  -0.622  -12.239 1.00 35.28  ? 450 HOH H O   1 
HETATM 6696 O  O   . HOH M 5 .   ? -8.714  -11.708 -17.130 1.00 31.82  ? 451 HOH H O   1 
HETATM 6697 O  O   . HOH M 5 .   ? -1.517  11.663  7.650   1.00 32.29  ? 452 HOH H O   1 
HETATM 6698 O  O   . HOH M 5 .   ? -0.140  -4.216  -3.323  1.00 31.78  ? 453 HOH H O   1 
HETATM 6699 O  O   . HOH M 5 .   ? -4.824  -13.734 -12.335 1.00 35.49  ? 454 HOH H O   1 
HETATM 6700 O  O   . HOH M 5 .   ? -11.080 -10.321 -19.831 1.00 33.40  ? 455 HOH H O   1 
HETATM 6701 O  O   . HOH M 5 .   ? -3.488  -9.255  1.339   1.00 32.51  ? 456 HOH H O   1 
HETATM 6702 O  O   . HOH M 5 .   ? 12.682  -5.709  7.992   1.00 31.72  ? 457 HOH H O   1 
HETATM 6703 O  O   . HOH M 5 .   ? -22.943 -8.323  -8.392  1.00 33.35  ? 458 HOH H O   1 
HETATM 6704 O  O   . HOH M 5 .   ? -19.562 -4.729  -13.955 1.00 35.35  ? 459 HOH H O   1 
HETATM 6705 O  O   . HOH M 5 .   ? 6.560   13.018  1.722   1.00 33.85  ? 460 HOH H O   1 
HETATM 6706 O  O   . HOH M 5 .   ? -1.220  4.442   8.666   1.00 37.44  ? 461 HOH H O   1 
HETATM 6707 O  O   . HOH M 5 .   ? 3.312   14.179  -11.259 1.00 35.45  ? 462 HOH H O   1 
HETATM 6708 O  O   . HOH M 5 .   ? 15.165  -10.206 5.912   1.00 33.90  ? 463 HOH H O   1 
HETATM 6709 O  O   . HOH M 5 .   ? 20.608  5.105   -1.236  1.00 36.60  ? 464 HOH H O   1 
HETATM 6710 O  O   . HOH M 5 .   ? 0.374   -1.538  2.795   1.00 36.73  ? 465 HOH H O   1 
HETATM 6711 O  O   . HOH M 5 .   ? -9.392  9.373   9.998   1.00 33.36  ? 466 HOH H O   1 
HETATM 6712 O  O   . HOH M 5 .   ? -17.823 10.916  3.725   1.00 35.73  ? 467 HOH H O   1 
HETATM 6713 O  O   . HOH M 5 .   ? 17.338  12.082  8.342   1.00 35.22  ? 468 HOH H O   1 
HETATM 6714 O  O   . HOH M 5 .   ? 7.374   16.074  -6.211  1.00 32.91  ? 469 HOH H O   1 
HETATM 6715 O  O   . HOH M 5 .   ? -18.624 -9.439  -14.858 1.00 35.88  ? 470 HOH H O   1 
HETATM 6716 O  O   . HOH M 5 .   ? -14.837 -15.396 -16.164 1.00 35.61  ? 471 HOH H O   1 
HETATM 6717 O  O   . HOH M 5 .   ? 9.987   -5.719  12.845  1.00 36.14  ? 472 HOH H O   1 
HETATM 6718 O  O   . HOH M 5 .   ? 6.061   5.916   11.219  1.00 36.06  ? 473 HOH H O   1 
HETATM 6719 O  O   . HOH M 5 .   ? -4.931  -1.780  -15.588 1.00 36.66  ? 474 HOH H O   1 
HETATM 6720 O  O   . HOH M 5 .   ? 2.075   -4.426  -6.459  1.00 37.29  ? 475 HOH H O   1 
HETATM 6721 O  O   . HOH M 5 .   ? 18.377  14.223  8.193   1.00 35.39  ? 476 HOH H O   1 
HETATM 6722 O  O   . HOH M 5 .   ? -23.431 12.802  -3.848  1.00 37.45  ? 477 HOH H O   1 
HETATM 6723 O  O   . HOH M 5 .   ? -2.238  -9.420  3.267   1.00 39.82  ? 478 HOH H O   1 
HETATM 6724 O  O   . HOH M 5 .   ? 21.179  11.540  -0.351  1.00 43.32  ? 479 HOH H O   1 
HETATM 6725 O  O   . HOH M 5 .   ? 15.166  -4.548  0.933   1.00 40.90  ? 480 HOH H O   1 
HETATM 6726 O  O   . HOH M 5 .   ? -6.997  -1.937  -16.855 1.00 34.28  ? 481 HOH H O   1 
HETATM 6727 O  O   . HOH M 5 .   ? 25.297  -6.811  21.737  1.00 33.18  ? 482 HOH H O   1 
HETATM 6728 O  O   . HOH M 5 .   ? 24.960  -4.387  20.328  1.00 40.57  ? 483 HOH H O   1 
HETATM 6729 O  O   . HOH M 5 .   ? -18.294 14.900  1.584   1.00 39.06  ? 484 HOH H O   1 
HETATM 6730 O  O   . HOH M 5 .   ? -1.403  -10.627 -2.767  1.00 39.65  ? 485 HOH H O   1 
HETATM 6731 O  O   . HOH M 5 .   ? -0.037  -8.083  3.697   1.00 36.68  ? 486 HOH H O   1 
HETATM 6732 O  O   . HOH M 5 .   ? -27.550 -5.649  -7.101  1.00 39.12  ? 487 HOH H O   1 
HETATM 6733 O  O   . HOH M 5 .   ? -5.342  13.439  5.283   1.00 42.93  ? 488 HOH H O   1 
HETATM 6734 O  O   . HOH M 5 .   ? 2.242   -5.790  -2.837  1.00 45.80  ? 489 HOH H O   1 
HETATM 6735 O  O   . HOH M 5 .   ? 16.171  -7.876  -0.502  1.00 43.45  ? 490 HOH H O   1 
HETATM 6736 O  O   . HOH M 5 .   ? -13.528 -18.014 -1.736  1.00 40.72  ? 491 HOH H O   1 
HETATM 6737 O  O   . HOH M 5 .   ? -25.955 -11.102 -11.792 1.00 38.44  ? 492 HOH H O   1 
HETATM 6738 O  O   . HOH M 5 .   ? -5.014  -16.600 -11.530 1.00 45.51  ? 493 HOH H O   1 
HETATM 6739 O  O   . HOH M 5 .   ? 15.734  15.338  14.594  1.00 38.49  ? 494 HOH H O   1 
HETATM 6740 O  O   . HOH M 5 .   ? 3.664   13.716  2.537   1.00 45.48  ? 495 HOH H O   1 
HETATM 6741 O  O   . HOH M 5 .   ? -4.460  19.566  -12.862 1.00 43.06  ? 496 HOH H O   1 
HETATM 6742 O  O   . HOH M 5 .   ? 3.322   6.140   4.788   1.00 46.36  ? 497 HOH H O   1 
HETATM 6743 O  O   . HOH M 5 .   ? 11.799  -9.838  9.770   1.00 43.30  ? 498 HOH H O   1 
HETATM 6744 O  O   . HOH M 5 .   ? -5.869  19.905  0.102   1.00 41.89  ? 499 HOH H O   1 
HETATM 6745 O  O   . HOH M 5 .   ? 12.998  -8.847  7.644   1.00 39.46  ? 500 HOH H O   1 
HETATM 6746 O  O   . HOH M 5 .   ? 18.805  -7.204  21.569  1.00 42.68  ? 501 HOH H O   1 
HETATM 6747 O  O   . HOH M 5 .   ? 4.444   3.989   4.448   1.00 50.33  ? 502 HOH H O   1 
HETATM 6748 O  O   . HOH M 5 .   ? 27.376  -17.743 11.441  1.00 51.88  ? 503 HOH H O   1 
HETATM 6749 O  O   . HOH M 5 .   ? 7.205   6.101   -2.946  1.00 37.29  ? 504 HOH H O   1 
HETATM 6750 O  O   . HOH M 5 .   ? -12.825 -8.707  -21.596 1.00 40.65  ? 505 HOH H O   1 
HETATM 6751 O  O   . HOH M 5 .   ? 20.541  13.913  6.417   1.00 41.62  ? 506 HOH H O   1 
HETATM 6752 O  O   . HOH M 5 .   ? 2.852   11.596  4.299   1.00 42.92  ? 507 HOH H O   1 
HETATM 6753 O  O   . HOH M 5 .   ? 4.123   9.032   3.882   1.00 47.33  ? 508 HOH H O   1 
HETATM 6754 O  O   . HOH M 5 .   ? -6.809  12.508  -16.605 1.00 46.89  ? 509 HOH H O   1 
HETATM 6755 O  O   . HOH M 5 .   ? -4.500  -13.366 -15.317 1.00 47.56  ? 510 HOH H O   1 
HETATM 6756 O  O   . HOH M 5 .   ? 9.737   17.285  11.265  1.00 37.93  ? 511 HOH H O   1 
HETATM 6757 O  O   . HOH M 5 .   ? 27.068  -19.323 13.224  1.00 50.35  ? 512 HOH H O   1 
HETATM 6758 O  O   . HOH M 5 .   ? 11.068  -15.417 11.288  1.00 49.82  ? 513 HOH H O   1 
HETATM 6759 O  O   . HOH M 5 .   ? 16.777  -18.740 16.446  1.00 35.91  ? 514 HOH H O   1 
HETATM 6760 O  O   . HOH M 5 .   ? 16.499  -19.297 13.498  1.00 42.20  ? 515 HOH H O   1 
HETATM 6761 O  O   . HOH M 5 .   ? -20.902 -10.538 -13.016 1.00 41.16  ? 516 HOH H O   1 
HETATM 6762 O  O   . HOH M 5 .   ? -0.570  -0.244  5.311   1.00 36.17  ? 517 HOH H O   1 
HETATM 6763 O  O   . HOH M 5 .   ? 27.951  -4.995  1.429   1.00 41.87  ? 518 HOH H O   1 
HETATM 6764 O  O   . HOH M 5 .   ? -1.428  20.054  -2.456  1.00 20.22  ? 519 HOH H O   1 
HETATM 6765 O  O   . HOH M 5 .   ? -21.282 -11.659 -3.841  1.00 41.46  ? 520 HOH H O   1 
HETATM 6766 O  O   . HOH M 5 .   ? -3.070  -8.496  -15.986 1.00 42.82  ? 521 HOH H O   1 
HETATM 6767 O  O   . HOH M 5 .   ? -9.223  -12.979 3.798   1.00 42.46  ? 522 HOH H O   1 
HETATM 6768 O  O   . HOH M 5 .   ? 24.843  11.470  9.659   1.00 41.33  ? 523 HOH H O   1 
HETATM 6769 O  O   . HOH M 5 .   ? -2.707  -10.471 -1.025  1.00 40.76  ? 524 HOH H O   1 
HETATM 6770 O  O   . HOH M 5 .   ? -4.316  -18.038 -6.800  1.00 44.11  ? 525 HOH H O   1 
HETATM 6771 O  O   . HOH M 5 .   ? -3.727  -16.818 -4.927  1.00 40.02  ? 526 HOH H O   1 
HETATM 6772 O  O   . HOH M 5 .   ? -7.515  -20.498 -1.263  1.00 42.18  ? 527 HOH H O   1 
HETATM 6773 O  O   . HOH M 5 .   ? -15.361 -14.234 5.604   1.00 43.69  ? 528 HOH H O   1 
HETATM 6774 O  O   . HOH M 5 .   ? -11.076 16.913  -11.694 1.00 39.83  ? 529 HOH H O   1 
HETATM 6775 O  O   . HOH M 5 .   ? 19.467  11.644  -3.823  1.00 32.92  ? 530 HOH H O   1 
HETATM 6776 O  O   . HOH M 5 .   ? -16.429 -16.814 -5.218  1.00 41.35  ? 531 HOH H O   1 
HETATM 6777 O  O   . HOH M 5 .   ? 10.553  21.242  -5.144  1.00 46.98  ? 532 HOH H O   1 
HETATM 6778 O  O   . HOH M 5 .   ? 26.239  -4.818  -3.541  1.00 33.81  ? 533 HOH H O   1 
HETATM 6779 O  O   . HOH M 5 .   ? 20.907  10.708  2.638   1.00 39.75  ? 534 HOH H O   1 
HETATM 6780 O  O   . HOH M 5 .   ? 5.492   16.094  9.385   1.00 39.92  ? 535 HOH H O   1 
HETATM 6781 O  O   . HOH M 5 .   ? -2.154  -12.897 -15.177 1.00 48.94  ? 536 HOH H O   1 
HETATM 6782 O  O   . HOH M 5 .   ? -24.140 13.687  0.166   1.00 42.76  ? 537 HOH H O   1 
HETATM 6783 O  O   . HOH M 5 .   ? 21.748  -4.484  -3.156  1.00 41.83  ? 538 HOH H O   1 
HETATM 6784 O  O   . HOH M 5 .   ? -0.393  -7.162  -9.912  1.00 42.87  ? 539 HOH H O   1 
HETATM 6785 O  O   . HOH M 5 .   ? 19.251  -8.320  -1.907  1.00 42.94  ? 540 HOH H O   1 
HETATM 6786 O  O   . HOH M 5 .   ? 22.996  -10.143 1.088   1.00 30.46  ? 541 HOH H O   1 
HETATM 6787 O  O   . HOH M 5 .   ? -8.130  -16.016 -12.859 1.00 39.11  ? 542 HOH H O   1 
HETATM 6788 O  O   . HOH M 5 .   ? 4.887   5.243   -3.658  1.00 31.93  ? 543 HOH H O   1 
HETATM 6789 O  O   . HOH M 5 .   ? 2.253   -6.041  -9.517  1.00 45.21  ? 544 HOH H O   1 
HETATM 6790 O  O   . HOH M 5 .   ? -15.599 -12.556 -0.463  1.00 37.54  ? 545 HOH H O   1 
HETATM 6791 O  O   . HOH M 5 .   ? -8.511  13.794  3.304   1.00 30.79  ? 546 HOH H O   1 
HETATM 6792 O  O   . HOH M 5 .   ? -12.489 15.902  -2.752  1.00 33.30  ? 547 HOH H O   1 
HETATM 6793 O  O   . HOH M 5 .   ? -13.404 18.688  -3.762  1.00 49.98  ? 548 HOH H O   1 
HETATM 6794 O  O   . HOH M 5 .   ? 14.676  0.217   -5.627  1.00 30.43  ? 549 HOH H O   1 
HETATM 6795 O  O   . HOH M 5 .   ? -14.043 7.928   7.526   1.00 37.34  ? 550 HOH H O   1 
HETATM 6796 O  O   . HOH M 5 .   ? 8.617   -4.198  10.494  1.00 37.46  ? 551 HOH H O   1 
HETATM 6797 O  O   . HOH M 5 .   ? -6.289  9.789   -17.315 1.00 42.37  ? 552 HOH H O   1 
HETATM 6798 O  O   . HOH M 5 .   ? 0.244   18.751  -12.361 1.00 41.29  ? 553 HOH H O   1 
HETATM 6799 O  O   . HOH M 5 .   ? 29.656  -2.820  3.200   1.00 28.92  ? 554 HOH H O   1 
HETATM 6800 O  O   . HOH M 5 .   ? 14.884  -2.907  -5.585  1.00 41.95  ? 555 HOH H O   1 
HETATM 6801 O  O   . HOH M 5 .   ? 31.019  1.069   16.823  1.00 40.28  ? 556 HOH H O   1 
HETATM 6802 O  O   . HOH M 5 .   ? 13.823  9.702   -8.900  1.00 44.76  ? 557 HOH H O   1 
HETATM 6803 O  O   . HOH M 5 .   ? -8.934  18.289  -5.820  1.00 28.69  ? 558 HOH H O   1 
HETATM 6804 O  O   . HOH M 5 .   ? -9.980  17.999  -3.909  1.00 40.02  ? 559 HOH H O   1 
HETATM 6805 O  O   . HOH M 5 .   ? 13.877  17.106  -0.830  1.00 45.08  ? 560 HOH H O   1 
HETATM 6806 O  O   . HOH M 5 .   ? 4.979   10.000  -11.454 1.00 46.49  ? 561 HOH H O   1 
HETATM 6807 O  O   . HOH M 5 .   ? -24.958 9.828   -6.218  1.00 31.58  ? 562 HOH H O   1 
HETATM 6808 O  O   . HOH M 5 .   ? -8.823  10.969  7.184   1.00 45.05  ? 563 HOH H O   1 
HETATM 6809 O  O   . HOH M 5 .   ? 1.730   1.401   6.345   1.00 48.76  ? 564 HOH H O   1 
HETATM 6810 O  O   . HOH M 5 .   ? 30.455  -17.140 16.537  1.00 65.94  ? 565 HOH H O   1 
HETATM 6811 O  O   . HOH M 5 .   ? -5.377  -13.838 0.677   1.00 48.78  ? 566 HOH H O   1 
HETATM 6812 O  O   . HOH M 5 .   ? 26.200  -11.572 3.803   1.00 45.79  ? 567 HOH H O   1 
HETATM 6813 O  O   . HOH M 5 .   ? 8.811   17.832  -11.791 1.00 51.89  ? 568 HOH H O   1 
HETATM 6814 O  O   . HOH M 5 .   ? 9.889   8.530   -7.565  1.00 47.47  ? 569 HOH H O   1 
HETATM 6815 O  O   . HOH M 5 .   ? 25.359  4.876   1.990   1.00 41.76  ? 570 HOH H O   1 
HETATM 6816 O  O   . HOH M 5 .   ? 10.112  5.814   -9.374  1.00 44.90  ? 571 HOH H O   1 
HETATM 6817 O  O   . HOH M 5 .   ? 4.945   7.966   8.355   1.00 36.10  ? 572 HOH H O   1 
HETATM 6818 O  O   . HOH M 5 .   ? -2.729  21.764  -4.379  1.00 49.09  ? 573 HOH H O   1 
HETATM 6819 O  O   . HOH M 5 .   ? -7.639  16.981  -14.935 1.00 49.46  ? 574 HOH H O   1 
HETATM 6820 O  O   . HOH M 5 .   ? -3.287  -10.369 5.155   1.00 52.20  ? 575 HOH H O   1 
HETATM 6821 O  O   . HOH M 5 .   ? -7.442  5.086   -16.204 1.00 28.88  ? 576 HOH H O   1 
HETATM 6822 O  O   . HOH M 5 .   ? -5.364  19.814  -8.062  1.00 35.83  ? 577 HOH H O   1 
HETATM 6823 O  O   . HOH M 5 .   ? -5.434  5.561   -17.851 1.00 38.01  ? 578 HOH H O   1 
HETATM 6824 O  O   . HOH M 5 .   ? 6.357   8.866   9.813   1.00 42.96  ? 579 HOH H O   1 
HETATM 6825 O  O   . HOH M 5 .   ? -1.501  4.713   5.261   1.00 26.83  ? 580 HOH H O   1 
HETATM 6826 O  O   . HOH M 5 .   ? 22.666  9.743   -0.939  1.00 47.93  ? 581 HOH H O   1 
HETATM 6827 O  O   . HOH M 5 .   ? -19.705 -11.009 -17.295 1.00 45.28  ? 582 HOH H O   1 
HETATM 6828 O  O   . HOH M 5 .   ? -7.996  -22.779 0.409   1.00 32.20  ? 583 HOH H O   1 
HETATM 6829 O  O   . HOH M 5 .   ? -27.051 -1.728  -16.273 1.00 40.93  ? 584 HOH H O   1 
HETATM 6830 O  O   . HOH M 5 .   ? -7.443  1.221   -17.806 1.00 35.51  ? 585 HOH H O   1 
HETATM 6831 O  O   . HOH M 5 .   ? -5.785  1.762   -17.317 1.00 41.72  ? 586 HOH H O   1 
HETATM 6832 O  O   . HOH M 5 .   ? 7.475   16.826  -14.116 1.00 55.29  ? 587 HOH H O   1 
HETATM 6833 O  O   . HOH M 5 .   ? -20.452 -5.636  -17.690 1.00 33.22  ? 588 HOH H O   1 
HETATM 6834 O  O   . HOH M 5 .   ? 1.211   4.273   -11.677 1.00 37.83  ? 589 HOH H O   1 
HETATM 6835 O  O   . HOH M 5 .   ? 22.080  6.274   -4.050  1.00 47.47  ? 590 HOH H O   1 
HETATM 6836 O  O   . HOH M 5 .   ? 13.519  4.318   13.748  1.00 36.46  ? 591 HOH H O   1 
HETATM 6837 O  O   . HOH M 5 .   ? -0.204  5.409   3.929   1.00 32.03  ? 592 HOH H O   1 
HETATM 6838 O  O   . HOH M 5 .   ? 23.267  -8.343  -2.039  1.00 47.20  ? 593 HOH H O   1 
HETATM 6839 O  O   . HOH M 5 .   ? -15.751 -18.241 -1.440  1.00 49.94  ? 594 HOH H O   1 
HETATM 6840 O  O   . HOH M 5 .   ? -26.914 -13.987 -11.275 1.00 52.29  ? 595 HOH H O   1 
HETATM 6841 O  O   . HOH N 5 .   ? -24.152 -6.717  3.161   1.00 19.90  ? 401 HOH P O   1 
HETATM 6842 O  O   . HOH N 5 .   ? -27.971 0.228   -9.597  1.00 35.87  ? 402 HOH P O   1 
HETATM 6843 O  O   . HOH N 5 .   ? -30.700 2.339   -4.515  1.00 40.78  ? 403 HOH P O   1 
HETATM 6844 O  O   . HOH N 5 .   ? -23.302 -11.342 3.557   1.00 38.71  ? 404 HOH P O   1 
HETATM 6845 O  O   . HOH N 5 .   ? -28.857 1.712   -7.648  1.00 39.96  ? 405 HOH P O   1 
HETATM 6846 O  O   . HOH N 5 .   ? -18.701 -14.373 -1.999  1.00 42.29  ? 406 HOH P O   1 
HETATM 6847 O  O   . HOH O 5 .   ? 17.062  -35.475 16.148  1.00 16.50  ? 401 HOH M O   1 
HETATM 6848 O  O   . HOH O 5 .   ? 19.558  -39.482 15.229  1.00 17.03  ? 402 HOH M O   1 
HETATM 6849 O  O   . HOH O 5 .   ? 18.625  -31.603 12.858  1.00 15.50  ? 403 HOH M O   1 
HETATM 6850 O  O   . HOH O 5 .   ? 22.212  -30.400 9.913   1.00 16.06  ? 404 HOH M O   1 
HETATM 6851 O  O   . HOH O 5 .   ? 8.271   -30.003 26.406  1.00 18.19  ? 405 HOH M O   1 
HETATM 6852 O  O   . HOH O 5 .   ? 17.555  -42.081 25.265  1.00 18.82  ? 406 HOH M O   1 
HETATM 6853 O  O   . HOH O 5 .   ? 17.325  -43.951 19.374  1.00 17.19  ? 407 HOH M O   1 
HETATM 6854 O  O   . HOH O 5 .   ? 51.847  -30.878 12.853  1.00 19.33  ? 408 HOH M O   1 
HETATM 6855 O  O   . HOH O 5 .   ? 29.791  -33.499 21.141  1.00 20.86  ? 409 HOH M O   1 
HETATM 6856 O  O   . HOH O 5 .   ? 3.422   -41.867 39.531  1.00 22.16  ? 410 HOH M O   1 
HETATM 6857 O  O   . HOH O 5 .   ? 12.433  -43.369 32.341  1.00 22.07  ? 411 HOH M O   1 
HETATM 6858 O  O   . HOH O 5 .   ? 8.202   -41.450 44.584  1.00 20.99  ? 412 HOH M O   1 
HETATM 6859 O  O   . HOH O 5 .   ? 9.445   -22.994 24.844  1.00 23.07  ? 413 HOH M O   1 
HETATM 6860 O  O   . HOH O 5 .   ? 38.572  -38.152 16.225  1.00 17.86  ? 414 HOH M O   1 
HETATM 6861 O  O   . HOH O 5 .   ? 55.726  -40.261 26.904  1.00 21.78  ? 415 HOH M O   1 
HETATM 6862 O  O   . HOH O 5 .   ? 19.076  -22.740 34.482  1.00 23.48  ? 416 HOH M O   1 
HETATM 6863 O  O   . HOH O 5 .   ? 26.361  -28.599 31.956  1.00 24.19  ? 417 HOH M O   1 
HETATM 6864 O  O   . HOH O 5 .   ? 14.843  -43.073 27.544  1.00 21.36  ? 418 HOH M O   1 
HETATM 6865 O  O   . HOH O 5 .   ? 25.374  -36.942 30.137  1.00 23.27  ? 419 HOH M O   1 
HETATM 6866 O  O   . HOH O 5 .   ? 24.360  -23.984 24.856  1.00 23.61  ? 420 HOH M O   1 
HETATM 6867 O  O   . HOH O 5 .   ? 31.286  -32.689 23.183  1.00 22.19  ? 421 HOH M O   1 
HETATM 6868 O  O   . HOH O 5 .   ? 46.686  -26.846 15.972  1.00 26.57  ? 422 HOH M O   1 
HETATM 6869 O  O   . HOH O 5 .   ? 9.513   -44.262 37.909  1.00 21.23  ? 423 HOH M O   1 
HETATM 6870 O  O   . HOH O 5 .   ? 7.791   -28.286 35.441  1.00 23.32  ? 424 HOH M O   1 
HETATM 6871 O  O   . HOH O 5 .   ? 17.216  -22.223 13.276  1.00 25.15  ? 425 HOH M O   1 
HETATM 6872 O  O   . HOH O 5 .   ? 28.855  -21.850 16.776  1.00 23.39  ? 426 HOH M O   1 
HETATM 6873 O  O   . HOH O 5 .   ? 39.686  -27.612 20.413  1.00 27.93  ? 427 HOH M O   1 
HETATM 6874 O  O   . HOH O 5 .   ? 22.782  -25.903 36.739  1.00 24.95  ? 428 HOH M O   1 
HETATM 6875 O  O   . HOH O 5 .   ? 44.583  -27.441 14.170  1.00 26.25  ? 429 HOH M O   1 
HETATM 6876 O  O   . HOH O 5 .   ? 6.656   -28.389 39.066  1.00 25.23  ? 430 HOH M O   1 
HETATM 6877 O  O   . HOH O 5 .   ? 11.683  -44.875 34.877  1.00 24.92  ? 431 HOH M O   1 
HETATM 6878 O  O   . HOH O 5 .   ? 10.619  -40.916 22.491  1.00 27.69  ? 432 HOH M O   1 
HETATM 6879 O  O   . HOH O 5 .   ? 29.155  -21.621 19.793  1.00 25.93  ? 433 HOH M O   1 
HETATM 6880 O  O   . HOH O 5 .   ? 7.559   -44.710 27.908  1.00 27.87  ? 434 HOH M O   1 
HETATM 6881 O  O   . HOH O 5 .   ? 13.543  -23.518 18.456  1.00 28.35  ? 435 HOH M O   1 
HETATM 6882 O  O   . HOH O 5 .   ? 45.088  -41.896 25.145  1.00 28.38  ? 436 HOH M O   1 
HETATM 6883 O  O   . HOH O 5 .   ? 1.889   -44.008 26.824  1.00 30.70  ? 437 HOH M O   1 
HETATM 6884 O  O   . HOH O 5 .   ? 27.651  -34.375 22.675  1.00 28.53  ? 438 HOH M O   1 
HETATM 6885 O  O   . HOH O 5 .   ? 30.037  -27.514 23.570  1.00 27.97  ? 439 HOH M O   1 
HETATM 6886 O  O   . HOH O 5 .   ? 34.175  -36.202 22.767  1.00 27.83  ? 440 HOH M O   1 
HETATM 6887 O  O   . HOH O 5 .   ? 48.384  -47.714 25.766  1.00 27.84  ? 441 HOH M O   1 
HETATM 6888 O  O   . HOH O 5 .   ? 56.507  -33.675 17.915  1.00 27.51  ? 442 HOH M O   1 
HETATM 6889 O  O   . HOH O 5 .   ? 37.971  -29.389 22.340  1.00 30.75  ? 443 HOH M O   1 
HETATM 6890 O  O   . HOH O 5 .   ? 13.923  -44.727 30.303  1.00 33.50  ? 444 HOH M O   1 
HETATM 6891 O  O   . HOH O 5 .   ? 12.296  -43.457 37.161  1.00 29.88  ? 445 HOH M O   1 
HETATM 6892 O  O   . HOH O 5 .   ? 33.371  -36.156 12.905  1.00 26.18  ? 446 HOH M O   1 
HETATM 6893 O  O   . HOH O 5 .   ? 35.268  -25.327 25.096  1.00 30.91  ? 447 HOH M O   1 
HETATM 6894 O  O   . HOH O 5 .   ? 45.113  -39.336 27.875  1.00 30.97  ? 448 HOH M O   1 
HETATM 6895 O  O   . HOH O 5 .   ? 31.364  -35.174 11.069  1.00 32.81  ? 449 HOH M O   1 
HETATM 6896 O  O   . HOH O 5 .   ? 42.796  -26.388 8.294   1.00 29.34  ? 450 HOH M O   1 
HETATM 6897 O  O   . HOH O 5 .   ? 32.196  -36.721 15.953  1.00 31.00  ? 451 HOH M O   1 
HETATM 6898 O  O   . HOH O 5 .   ? 29.973  -31.032 25.267  1.00 29.20  ? 452 HOH M O   1 
HETATM 6899 O  O   . HOH O 5 .   ? 0.946   -38.992 36.934  1.00 30.14  ? 453 HOH M O   1 
HETATM 6900 O  O   . HOH O 5 .   ? 41.921  -44.493 15.331  1.00 27.05  ? 454 HOH M O   1 
HETATM 6901 O  O   . HOH O 5 .   ? 22.571  -41.430 24.553  1.00 27.75  ? 455 HOH M O   1 
HETATM 6902 O  O   . HOH O 5 .   ? 7.264   -47.757 28.650  1.00 32.05  ? 456 HOH M O   1 
HETATM 6903 O  O   . HOH O 5 .   ? 58.917  -37.096 27.477  1.00 31.68  ? 457 HOH M O   1 
HETATM 6904 O  O   . HOH O 5 .   ? 11.024  -20.810 24.299  1.00 30.04  ? 458 HOH M O   1 
HETATM 6905 O  O   . HOH O 5 .   ? 31.422  -35.842 20.690  1.00 29.90  ? 459 HOH M O   1 
HETATM 6906 O  O   . HOH O 5 .   ? 38.462  -40.843 16.998  1.00 34.04  ? 460 HOH M O   1 
HETATM 6907 O  O   . HOH O 5 .   ? 13.022  -20.837 19.354  1.00 31.79  ? 461 HOH M O   1 
HETATM 6908 O  O   . HOH O 5 .   ? 46.346  -42.946 10.271  1.00 33.50  ? 462 HOH M O   1 
HETATM 6909 O  O   . HOH O 5 .   ? 40.949  -46.473 22.533  1.00 31.78  ? 463 HOH M O   1 
HETATM 6910 O  O   . HOH O 5 .   ? 29.191  -35.997 12.666  1.00 29.26  ? 464 HOH M O   1 
HETATM 6911 O  O   . HOH O 5 .   ? 16.380  -43.512 32.070  1.00 36.36  ? 465 HOH M O   1 
HETATM 6912 O  O   . HOH O 5 .   ? 56.354  -33.055 20.656  1.00 29.53  ? 466 HOH M O   1 
HETATM 6913 O  O   . HOH O 5 .   ? 53.007  -29.828 15.445  1.00 37.63  ? 467 HOH M O   1 
HETATM 6914 O  O   . HOH O 5 .   ? 27.610  -34.920 28.840  1.00 35.72  ? 468 HOH M O   1 
HETATM 6915 O  O   . HOH O 5 .   ? 9.496   -46.715 38.827  1.00 33.48  ? 469 HOH M O   1 
HETATM 6916 O  O   . HOH O 5 .   ? 43.488  -30.365 4.855   1.00 35.96  ? 470 HOH M O   1 
HETATM 6917 O  O   . HOH O 5 .   ? 46.774  -31.485 7.197   1.00 32.71  ? 471 HOH M O   1 
HETATM 6918 O  O   . HOH O 5 .   ? 31.825  -29.928 8.234   1.00 35.43  ? 472 HOH M O   1 
HETATM 6919 O  O   . HOH O 5 .   ? 46.763  -39.866 3.879   1.00 37.94  ? 473 HOH M O   1 
HETATM 6920 O  O   . HOH O 5 .   ? 38.701  -27.165 23.992  1.00 39.29  ? 474 HOH M O   1 
HETATM 6921 O  O   . HOH O 5 .   ? 42.776  -32.797 6.406   1.00 35.37  ? 475 HOH M O   1 
HETATM 6922 O  O   . HOH O 5 .   ? 28.279  -30.333 7.898   1.00 35.87  ? 476 HOH M O   1 
HETATM 6923 O  O   . HOH O 5 .   ? 38.912  -39.002 8.870   1.00 37.79  ? 477 HOH M O   1 
HETATM 6924 O  O   . HOH O 5 .   ? 6.612   -25.780 38.010  1.00 32.12  ? 478 HOH M O   1 
HETATM 6925 O  O   . HOH O 5 .   ? 22.101  -17.281 21.650  1.00 35.60  ? 479 HOH M O   1 
HETATM 6926 O  O   . HOH O 5 .   ? 28.896  -34.642 34.270  1.00 35.40  ? 480 HOH M O   1 
HETATM 6927 O  O   . HOH O 5 .   ? -1.971  -41.673 32.539  1.00 37.31  ? 481 HOH M O   1 
HETATM 6928 O  O   . HOH O 5 .   ? 45.228  -26.591 10.331  1.00 39.36  ? 482 HOH M O   1 
HETATM 6929 O  O   . HOH O 5 .   ? 45.069  -33.706 7.684   1.00 39.41  ? 483 HOH M O   1 
HETATM 6930 O  O   . HOH O 5 .   ? 6.140   -45.016 44.841  1.00 37.41  ? 484 HOH M O   1 
HETATM 6931 O  O   . HOH O 5 .   ? 48.067  -29.799 9.549   1.00 37.69  ? 485 HOH M O   1 
HETATM 6932 O  O   . HOH O 5 .   ? 35.166  -24.988 12.962  1.00 35.84  ? 486 HOH M O   1 
HETATM 6933 O  O   . HOH O 5 .   ? -2.187  -34.792 37.384  1.00 36.26  ? 487 HOH M O   1 
HETATM 6934 O  O   . HOH O 5 .   ? 47.890  -48.612 14.577  1.00 35.82  ? 488 HOH M O   1 
HETATM 6935 O  O   . HOH O 5 .   ? 37.121  -22.929 12.618  1.00 36.72  ? 489 HOH M O   1 
HETATM 6936 O  O   . HOH O 5 .   ? 40.015  -40.978 8.886   1.00 38.14  ? 490 HOH M O   1 
HETATM 6937 O  O   . HOH O 5 .   ? 6.296   -44.545 26.036  1.00 38.30  ? 491 HOH M O   1 
HETATM 6938 O  O   . HOH O 5 .   ? 39.903  -30.525 7.567   1.00 35.55  ? 492 HOH M O   1 
HETATM 6939 O  O   . HOH O 5 .   ? 7.339   -21.834 23.287  1.00 40.00  ? 493 HOH M O   1 
HETATM 6940 O  O   . HOH O 5 .   ? 64.539  -38.394 16.033  1.00 39.20  ? 494 HOH M O   1 
HETATM 6941 O  O   . HOH O 5 .   ? 25.437  -26.540 30.698  1.00 37.49  ? 495 HOH M O   1 
HETATM 6942 O  O   . HOH O 5 .   ? 30.568  -34.852 36.882  1.00 39.33  ? 496 HOH M O   1 
HETATM 6943 O  O   . HOH O 5 .   ? 15.300  -16.377 28.842  1.00 42.62  ? 497 HOH M O   1 
HETATM 6944 O  O   . HOH O 5 .   ? 40.140  -29.479 25.878  1.00 39.47  ? 498 HOH M O   1 
HETATM 6945 O  O   . HOH O 5 .   ? 19.084  -20.780 11.506  1.00 43.45  ? 499 HOH M O   1 
HETATM 6946 O  O   . HOH O 5 .   ? 41.061  -28.604 6.134   1.00 43.00  ? 500 HOH M O   1 
HETATM 6947 O  O   . HOH O 5 .   ? 64.198  -42.939 24.424  1.00 43.44  ? 501 HOH M O   1 
HETATM 6948 O  O   . HOH O 5 .   ? 16.006  -45.155 26.544  1.00 40.43  ? 502 HOH M O   1 
HETATM 6949 O  O   . HOH O 5 .   ? 23.339  -21.959 26.296  1.00 44.39  ? 503 HOH M O   1 
HETATM 6950 O  O   . HOH O 5 .   ? 45.017  -27.193 6.551   1.00 42.77  ? 504 HOH M O   1 
HETATM 6951 O  O   . HOH O 5 .   ? 12.452  -15.415 28.823  1.00 36.96  ? 505 HOH M O   1 
HETATM 6952 O  O   . HOH O 5 .   ? 24.831  -24.301 35.178  1.00 38.98  ? 506 HOH M O   1 
HETATM 6953 O  O   . HOH O 5 .   ? 61.018  -35.844 28.791  1.00 47.88  ? 507 HOH M O   1 
HETATM 6954 O  O   . HOH O 5 .   ? 58.042  -46.229 11.894  1.00 44.50  ? 508 HOH M O   1 
HETATM 6955 O  O   . HOH O 5 .   ? 39.276  -22.716 14.508  1.00 43.99  ? 509 HOH M O   1 
HETATM 6956 O  O   . HOH O 5 .   ? 28.020  -34.799 25.446  1.00 38.92  ? 510 HOH M O   1 
HETATM 6957 O  O   . HOH O 5 .   ? 51.056  -55.427 16.293  1.00 46.59  ? 511 HOH M O   1 
HETATM 6958 O  O   . HOH O 5 .   ? 53.127  -53.157 8.917   1.00 48.38  ? 512 HOH M O   1 
HETATM 6959 O  O   . HOH O 5 .   ? 52.300  -44.081 5.622   1.00 47.89  ? 513 HOH M O   1 
HETATM 6960 O  O   . HOH O 5 .   ? 9.049   -43.284 21.608  1.00 39.18  ? 514 HOH M O   1 
HETATM 6961 O  O   . HOH O 5 .   ? 56.422  -52.556 34.731  1.00 46.89  ? 515 HOH M O   1 
HETATM 6962 O  O   . HOH O 5 .   ? 5.514   -24.202 22.900  1.00 44.07  ? 516 HOH M O   1 
HETATM 6963 O  O   . HOH O 5 .   ? 41.664  -22.737 13.073  1.00 41.16  ? 517 HOH M O   1 
HETATM 6964 O  O   . HOH O 5 .   ? 31.677  -33.363 8.860   1.00 36.12  ? 518 HOH M O   1 
HETATM 6965 O  O   . HOH O 5 .   ? 23.991  -19.456 12.239  1.00 40.35  ? 519 HOH M O   1 
HETATM 6966 O  O   . HOH O 5 .   ? 9.657   -28.095 20.224  1.00 35.71  ? 520 HOH M O   1 
HETATM 6967 O  O   . HOH O 5 .   ? 13.165  -23.806 14.301  1.00 28.22  ? 521 HOH M O   1 
HETATM 6968 O  O   . HOH O 5 .   ? 8.954   -26.173 18.907  1.00 43.47  ? 522 HOH M O   1 
HETATM 6969 O  O   . HOH O 5 .   ? 15.459  -16.967 18.932  1.00 39.68  ? 523 HOH M O   1 
HETATM 6970 O  O   . HOH O 5 .   ? 50.908  -29.813 10.162  1.00 29.57  ? 524 HOH M O   1 
HETATM 6971 O  O   . HOH O 5 .   ? 21.280  -21.595 33.322  1.00 31.64  ? 525 HOH M O   1 
HETATM 6972 O  O   . HOH O 5 .   ? 31.046  -25.648 7.428   1.00 42.79  ? 526 HOH M O   1 
HETATM 6973 O  O   . HOH O 5 .   ? 56.599  -54.207 15.370  1.00 43.00  ? 527 HOH M O   1 
HETATM 6974 O  O   . HOH O 5 .   ? 67.880  -37.028 27.104  1.00 40.55  ? 528 HOH M O   1 
HETATM 6975 O  O   . HOH O 5 .   ? 58.813  -35.964 12.638  1.00 34.53  ? 529 HOH M O   1 
HETATM 6976 O  O   . HOH O 5 .   ? 31.873  -28.823 25.491  1.00 29.77  ? 530 HOH M O   1 
HETATM 6977 O  O   . HOH O 5 .   ? 31.840  -27.942 5.471   1.00 42.86  ? 531 HOH M O   1 
HETATM 6978 O  O   . HOH O 5 .   ? 32.657  -25.378 5.372   1.00 41.89  ? 532 HOH M O   1 
HETATM 6979 O  O   . HOH O 5 .   ? 32.595  -29.169 27.555  1.00 39.76  ? 533 HOH M O   1 
HETATM 6980 O  O   . HOH O 5 .   ? 5.023   -43.013 45.460  1.00 31.64  ? 534 HOH M O   1 
HETATM 6981 O  O   . HOH O 5 .   ? 0.727   -46.975 32.756  1.00 43.99  ? 535 HOH M O   1 
HETATM 6982 O  O   . HOH O 5 .   ? 13.591  -19.295 35.947  1.00 38.37  ? 536 HOH M O   1 
HETATM 6983 O  O   . HOH O 5 .   ? 16.908  -16.248 20.690  1.00 42.36  ? 537 HOH M O   1 
HETATM 6984 O  O   . HOH O 5 .   ? 43.782  -26.977 21.184  1.00 38.34  ? 538 HOH M O   1 
HETATM 6985 O  O   . HOH O 5 .   ? 12.578  -46.139 28.001  1.00 38.66  ? 539 HOH M O   1 
HETATM 6986 O  O   . HOH O 5 .   ? 69.610  -36.871 25.483  1.00 36.46  ? 540 HOH M O   1 
HETATM 6987 O  O   . HOH O 5 .   ? 27.306  -39.634 20.064  1.00 43.16  ? 541 HOH M O   1 
HETATM 6988 O  O   . HOH O 5 .   ? 22.628  -40.600 26.870  1.00 33.43  ? 542 HOH M O   1 
HETATM 6989 O  O   . HOH O 5 .   ? 23.536  -40.652 28.685  1.00 33.80  ? 543 HOH M O   1 
HETATM 6990 O  O   . HOH O 5 .   ? 25.885  -26.104 34.486  1.00 41.93  ? 544 HOH M O   1 
HETATM 6991 O  O   . HOH O 5 .   ? 31.972  -35.542 24.995  1.00 36.25  ? 545 HOH M O   1 
HETATM 6992 O  O   . HOH O 5 .   ? 13.800  -19.333 17.615  1.00 41.21  ? 546 HOH M O   1 
HETATM 6993 O  O   . HOH O 5 .   ? 51.685  -53.560 23.483  1.00 45.74  ? 547 HOH M O   1 
HETATM 6994 O  O   . HOH O 5 .   ? 20.788  -43.659 29.454  1.00 32.36  ? 548 HOH M O   1 
HETATM 6995 O  O   . HOH O 5 .   ? 33.120  -30.158 29.596  1.00 39.23  ? 549 HOH M O   1 
HETATM 6996 O  O   . HOH O 5 .   ? 44.941  -51.739 21.218  1.00 40.09  ? 550 HOH M O   1 
HETATM 6997 O  O   . HOH O 5 .   ? 12.865  -47.768 34.780  1.00 41.93  ? 551 HOH M O   1 
HETATM 6998 O  O   . HOH O 5 .   ? 46.871  -50.327 26.182  1.00 34.25  ? 552 HOH M O   1 
HETATM 6999 O  O   . HOH O 5 .   ? 45.987  -30.704 21.518  1.00 29.63  ? 553 HOH M O   1 
HETATM 7000 O  O   . HOH O 5 .   ? 5.449   -22.281 37.645  1.00 47.93  ? 554 HOH M O   1 
HETATM 7001 O  O   . HOH O 5 .   ? 51.456  -27.725 17.562  1.00 43.29  ? 555 HOH M O   1 
HETATM 7002 O  O   . HOH O 5 .   ? 24.084  -44.068 20.880  1.00 40.52  ? 556 HOH M O   1 
HETATM 7003 O  O   . HOH O 5 .   ? 32.487  -23.554 12.684  1.00 35.55  ? 557 HOH M O   1 
HETATM 7004 O  O   . HOH O 5 .   ? 44.306  -24.700 13.175  1.00 37.82  ? 558 HOH M O   1 
HETATM 7005 O  O   . HOH O 5 .   ? 11.629  -43.378 40.000  1.00 21.43  ? 559 HOH M O   1 
HETATM 7006 O  O   . HOH O 5 .   ? 40.527  -42.072 6.308   1.00 43.94  ? 560 HOH M O   1 
HETATM 7007 O  O   . HOH O 5 .   ? -0.985  -44.291 47.669  1.00 35.94  ? 561 HOH M O   1 
HETATM 7008 O  O   . HOH O 5 .   ? 2.607   -46.065 37.989  1.00 40.91  ? 562 HOH M O   1 
HETATM 7009 O  O   . HOH O 5 .   ? -2.011  -40.845 37.198  1.00 44.27  ? 563 HOH M O   1 
HETATM 7010 O  O   . HOH O 5 .   ? 20.312  -44.038 25.453  1.00 41.77  ? 564 HOH M O   1 
HETATM 7011 O  O   . HOH O 5 .   ? 2.630   -24.878 30.401  1.00 37.94  ? 565 HOH M O   1 
HETATM 7012 O  O   . HOH O 5 .   ? 28.297  -37.743 21.615  1.00 46.15  ? 566 HOH M O   1 
HETATM 7013 O  O   . HOH O 5 .   ? 9.362   -48.354 36.594  1.00 46.41  ? 567 HOH M O   1 
HETATM 7014 O  O   . HOH O 5 .   ? 33.991  -32.514 37.526  1.00 55.78  ? 568 HOH M O   1 
HETATM 7015 O  O   . HOH O 5 .   ? 6.659   -47.998 35.714  1.00 36.95  ? 569 HOH M O   1 
HETATM 7016 O  O   . HOH O 5 .   ? 40.433  -42.321 17.312  1.00 48.63  ? 570 HOH M O   1 
HETATM 7017 O  O   . HOH O 5 .   ? 33.114  -26.222 27.564  1.00 45.09  ? 571 HOH M O   1 
HETATM 7018 O  O   . HOH O 5 .   ? 17.360  -20.004 35.448  1.00 42.35  ? 572 HOH M O   1 
HETATM 7019 O  O   . HOH O 5 .   ? 31.870  -26.539 25.557  1.00 36.09  ? 573 HOH M O   1 
HETATM 7020 O  O   . HOH O 5 .   ? 64.180  -52.668 31.914  1.00 50.90  ? 574 HOH M O   1 
HETATM 7021 O  O   . HOH O 5 .   ? 28.337  -28.004 8.695   1.00 39.44  ? 575 HOH M O   1 
HETATM 7022 O  O   . HOH O 5 .   ? 39.609  -46.006 24.842  1.00 42.59  ? 576 HOH M O   1 
HETATM 7023 O  O   . HOH O 5 .   ? 37.618  -45.660 26.225  1.00 50.94  ? 577 HOH M O   1 
HETATM 7024 O  O   . HOH O 5 .   ? 41.191  -25.037 20.805  1.00 50.41  ? 578 HOH M O   1 
HETATM 7025 O  O   . HOH O 5 .   ? 58.182  -39.013 9.568   1.00 48.77  ? 579 HOH M O   1 
HETATM 7026 O  O   . HOH O 5 .   ? 55.234  -46.025 31.753  1.00 42.11  ? 580 HOH M O   1 
HETATM 7027 O  O   . HOH O 5 .   ? 37.487  -41.191 23.391  1.00 35.72  ? 581 HOH M O   1 
HETATM 7028 O  O   . HOH O 5 .   ? 60.819  -55.198 29.047  1.00 47.14  ? 582 HOH M O   1 
HETATM 7029 O  O   . HOH O 5 .   ? 66.958  -50.360 17.322  1.00 45.15  ? 583 HOH M O   1 
HETATM 7030 O  O   . HOH O 5 .   ? -3.986  -30.012 30.446  1.00 47.27  ? 584 HOH M O   1 
HETATM 7031 O  O   . HOH O 5 .   ? 46.918  -45.418 28.265  1.00 46.88  ? 585 HOH M O   1 
HETATM 7032 O  O   . HOH O 5 .   ? 3.407   -46.041 33.970  1.00 27.74  ? 586 HOH M O   1 
HETATM 7033 O  O   . HOH O 5 .   ? 52.075  -53.337 19.531  1.00 40.21  ? 587 HOH M O   1 
HETATM 7034 O  O   . HOH O 5 .   ? 8.931   -18.924 28.191  1.00 40.45  ? 588 HOH M O   1 
HETATM 7035 O  O   . HOH O 5 .   ? 30.222  -24.075 28.230  1.00 45.27  ? 589 HOH M O   1 
HETATM 7036 O  O   . HOH O 5 .   ? 65.057  -55.887 31.092  1.00 49.05  ? 590 HOH M O   1 
HETATM 7037 O  O   . HOH O 5 .   ? 67.327  -54.627 26.492  1.00 45.97  ? 591 HOH M O   1 
HETATM 7038 O  O   . HOH O 5 .   ? 1.039   -46.639 44.035  1.00 40.47  ? 592 HOH M O   1 
HETATM 7039 O  O   . HOH O 5 .   ? 65.810  -53.555 29.319  1.00 48.68  ? 593 HOH M O   1 
HETATM 7040 O  O   . HOH O 5 .   ? 62.284  -40.411 13.093  1.00 41.60  ? 594 HOH M O   1 
HETATM 7041 O  O   . HOH O 5 .   ? 2.616   -45.057 45.338  1.00 47.34  ? 595 HOH M O   1 
HETATM 7042 O  O   . HOH O 5 .   ? 7.303   -19.124 26.989  1.00 51.13  ? 596 HOH M O   1 
HETATM 7043 O  O   . HOH O 5 .   ? 31.840  -38.206 19.152  1.00 49.92  ? 597 HOH M O   1 
HETATM 7044 O  O   . HOH P 5 .   ? 12.352  -40.727 55.120  1.00 12.57  ? 401 HOH I O   1 
HETATM 7045 O  O   . HOH P 5 .   ? 18.974  -40.898 32.406  1.00 14.80  ? 402 HOH I O   1 
HETATM 7046 O  O   . HOH P 5 .   ? 15.197  -30.667 43.364  1.00 15.04  ? 403 HOH I O   1 
HETATM 7047 O  O   . HOH P 5 .   ? 14.114  -39.024 56.409  1.00 17.22  ? 404 HOH I O   1 
HETATM 7048 O  O   . HOH P 5 .   ? 13.386  -44.632 52.355  1.00 18.18  ? 405 HOH I O   1 
HETATM 7049 O  O   . HOH P 5 .   ? 29.833  -54.994 44.786  1.00 15.92  ? 406 HOH I O   1 
HETATM 7050 O  O   . HOH P 5 .   ? 23.390  -43.533 36.032  1.00 19.31  ? 407 HOH I O   1 
HETATM 7051 O  O   . HOH P 5 .   ? 14.560  -43.397 39.679  1.00 18.93  ? 408 HOH I O   1 
HETATM 7052 O  O   . HOH P 5 .   ? 53.837  -24.974 40.957  1.00 18.66  ? 409 HOH I O   1 
HETATM 7053 O  O   . HOH P 5 .   ? 60.512  -32.087 39.029  1.00 20.65  ? 410 HOH I O   1 
HETATM 7054 O  O   . HOH P 5 .   ? 19.374  -38.797 56.002  1.00 21.20  ? 411 HOH I O   1 
HETATM 7055 O  O   . HOH P 5 .   ? 19.970  -24.864 36.238  1.00 21.25  ? 412 HOH I O   1 
HETATM 7056 O  O   . HOH P 5 .   ? 14.078  -34.272 57.375  1.00 20.68  ? 413 HOH I O   1 
HETATM 7057 O  O   . HOH P 5 .   ? 24.841  -45.655 40.477  1.00 25.52  ? 414 HOH I O   1 
HETATM 7058 O  O   . HOH P 5 .   ? 28.421  -37.202 36.645  1.00 22.73  ? 415 HOH I O   1 
HETATM 7059 O  O   . HOH P 5 .   ? 23.262  -24.792 39.304  1.00 23.50  ? 416 HOH I O   1 
HETATM 7060 O  O   . HOH P 5 .   ? 27.453  -24.371 49.797  1.00 22.71  ? 417 HOH I O   1 
HETATM 7061 O  O   . HOH P 5 .   ? 23.116  -51.910 45.439  1.00 23.47  ? 418 HOH I O   1 
HETATM 7062 O  O   . HOH P 5 .   ? 12.338  -47.663 40.797  1.00 25.21  ? 419 HOH I O   1 
HETATM 7063 O  O   . HOH P 5 .   ? 19.132  -43.722 32.040  1.00 25.79  ? 420 HOH I O   1 
HETATM 7064 O  O   . HOH P 5 .   ? 27.431  -48.056 38.875  1.00 26.08  ? 421 HOH I O   1 
HETATM 7065 O  O   . HOH P 5 .   ? 22.069  -53.284 47.913  1.00 28.68  ? 422 HOH I O   1 
HETATM 7066 O  O   . HOH P 5 .   ? 21.885  -37.878 58.571  1.00 27.13  ? 423 HOH I O   1 
HETATM 7067 O  O   . HOH P 5 .   ? 15.814  -46.281 37.854  1.00 26.38  ? 424 HOH I O   1 
HETATM 7068 O  O   . HOH P 5 .   ? 19.330  -45.692 55.076  1.00 28.97  ? 425 HOH I O   1 
HETATM 7069 O  O   . HOH P 5 .   ? 28.319  -36.157 54.839  1.00 28.53  ? 426 HOH I O   1 
HETATM 7070 O  O   . HOH P 5 .   ? 20.975  -49.636 42.339  1.00 26.65  ? 427 HOH I O   1 
HETATM 7071 O  O   . HOH P 5 .   ? 22.512  -48.919 39.231  1.00 27.87  ? 428 HOH I O   1 
HETATM 7072 O  O   . HOH P 5 .   ? 38.818  -33.140 28.385  1.00 24.58  ? 429 HOH I O   1 
HETATM 7073 O  O   . HOH P 5 .   ? 28.582  -30.420 51.944  1.00 28.94  ? 430 HOH I O   1 
HETATM 7074 O  O   . HOH P 5 .   ? 41.871  -32.096 36.418  1.00 31.53  ? 431 HOH I O   1 
HETATM 7075 O  O   . HOH P 5 .   ? 40.846  -29.597 29.122  1.00 32.04  ? 432 HOH I O   1 
HETATM 7076 O  O   . HOH P 5 .   ? 40.325  -35.370 32.735  1.00 29.29  ? 433 HOH I O   1 
HETATM 7077 O  O   . HOH P 5 .   ? 5.976   -45.167 48.508  1.00 27.05  ? 434 HOH I O   1 
HETATM 7078 O  O   . HOH P 5 .   ? 25.182  -24.342 43.286  1.00 27.28  ? 435 HOH I O   1 
HETATM 7079 O  O   . HOH P 5 .   ? 8.411   -44.946 46.663  1.00 31.19  ? 436 HOH I O   1 
HETATM 7080 O  O   . HOH P 5 .   ? 25.404  -50.930 55.263  1.00 29.64  ? 437 HOH I O   1 
HETATM 7081 O  O   . HOH P 5 .   ? 22.890  -44.994 38.301  1.00 28.26  ? 438 HOH I O   1 
HETATM 7082 O  O   . HOH P 5 .   ? 15.492  -18.598 51.520  1.00 27.47  ? 439 HOH I O   1 
HETATM 7083 O  O   . HOH P 5 .   ? 43.420  -40.825 28.996  1.00 31.13  ? 440 HOH I O   1 
HETATM 7084 O  O   . HOH P 5 .   ? 21.164  -52.145 43.415  1.00 31.32  ? 441 HOH I O   1 
HETATM 7085 O  O   . HOH P 5 .   ? 6.931   -30.741 45.782  1.00 33.04  ? 442 HOH I O   1 
HETATM 7086 O  O   . HOH P 5 .   ? 30.698  -30.690 38.564  1.00 31.38  ? 443 HOH I O   1 
HETATM 7087 O  O   . HOH P 5 .   ? 11.508  -30.469 56.197  1.00 33.10  ? 444 HOH I O   1 
HETATM 7088 O  O   . HOH P 5 .   ? 47.471  -40.088 27.793  1.00 31.50  ? 445 HOH I O   1 
HETATM 7089 O  O   . HOH P 5 .   ? 33.790  -34.543 50.505  1.00 30.56  ? 446 HOH I O   1 
HETATM 7090 O  O   . HOH P 5 .   ? 10.594  -50.542 47.268  1.00 31.38  ? 447 HOH I O   1 
HETATM 7091 O  O   . HOH P 5 .   ? 59.270  -35.679 19.711  1.00 28.49  ? 448 HOH I O   1 
HETATM 7092 O  O   . HOH P 5 .   ? 38.536  -37.886 33.568  1.00 33.86  ? 449 HOH I O   1 
HETATM 7093 O  O   . HOH P 5 .   ? 40.631  -43.548 49.883  1.00 34.11  ? 450 HOH I O   1 
HETATM 7094 O  O   . HOH P 5 .   ? 43.478  -29.563 34.212  1.00 31.26  ? 451 HOH I O   1 
HETATM 7095 O  O   . HOH P 5 .   ? 38.226  -50.968 48.840  1.00 32.45  ? 452 HOH I O   1 
HETATM 7096 O  O   . HOH P 5 .   ? 50.341  -26.582 43.958  1.00 40.59  ? 453 HOH I O   1 
HETATM 7097 O  O   . HOH P 5 .   ? 27.302  -26.012 40.820  1.00 32.58  ? 454 HOH I O   1 
HETATM 7098 O  O   . HOH P 5 .   ? 29.999  -48.731 56.829  1.00 34.81  ? 455 HOH I O   1 
HETATM 7099 O  O   . HOH P 5 .   ? 56.389  -28.442 20.584  1.00 33.69  ? 456 HOH I O   1 
HETATM 7100 O  O   . HOH P 5 .   ? 32.442  -49.698 40.895  1.00 39.00  ? 457 HOH I O   1 
HETATM 7101 O  O   . HOH P 5 .   ? 28.357  -23.377 47.244  1.00 38.80  ? 458 HOH I O   1 
HETATM 7102 O  O   . HOH P 5 .   ? 29.773  -25.395 50.909  1.00 35.61  ? 459 HOH I O   1 
HETATM 7103 O  O   . HOH P 5 .   ? 49.403  -21.346 27.868  1.00 36.50  ? 460 HOH I O   1 
HETATM 7104 O  O   . HOH P 5 .   ? 25.836  -24.101 39.298  1.00 35.67  ? 461 HOH I O   1 
HETATM 7105 O  O   . HOH P 5 .   ? 51.076  -39.956 43.511  1.00 30.60  ? 462 HOH I O   1 
HETATM 7106 O  O   . HOH P 5 .   ? 12.829  -45.948 38.768  1.00 37.36  ? 463 HOH I O   1 
HETATM 7107 O  O   . HOH P 5 .   ? 55.881  -30.856 21.797  1.00 37.97  ? 464 HOH I O   1 
HETATM 7108 O  O   . HOH P 5 .   ? 45.901  -32.010 47.871  1.00 35.23  ? 465 HOH I O   1 
HETATM 7109 O  O   . HOH P 5 .   ? 33.139  -30.961 48.562  1.00 38.97  ? 466 HOH I O   1 
HETATM 7110 O  O   . HOH P 5 .   ? 29.568  -47.250 34.468  1.00 36.59  ? 467 HOH I O   1 
HETATM 7111 O  O   . HOH P 5 .   ? 46.218  -30.397 41.376  1.00 37.51  ? 468 HOH I O   1 
HETATM 7112 O  O   . HOH P 5 .   ? 21.925  -22.107 38.689  1.00 36.77  ? 469 HOH I O   1 
HETATM 7113 O  O   . HOH P 5 .   ? 52.813  -40.621 45.030  1.00 34.84  ? 470 HOH I O   1 
HETATM 7114 O  O   . HOH P 5 .   ? 21.481  -53.938 41.465  1.00 32.79  ? 471 HOH I O   1 
HETATM 7115 O  O   . HOH P 5 .   ? 21.501  -44.706 32.488  1.00 36.66  ? 472 HOH I O   1 
HETATM 7116 O  O   . HOH P 5 .   ? 61.508  -33.007 33.015  1.00 38.18  ? 473 HOH I O   1 
HETATM 7117 O  O   . HOH P 5 .   ? 49.876  -45.834 46.784  1.00 34.51  ? 474 HOH I O   1 
HETATM 7118 O  O   . HOH P 5 .   ? 19.101  -53.661 47.380  1.00 39.67  ? 475 HOH I O   1 
HETATM 7119 O  O   . HOH P 5 .   ? 38.637  -30.548 27.453  1.00 37.78  ? 476 HOH I O   1 
HETATM 7120 O  O   . HOH P 5 .   ? 45.789  -34.573 47.685  1.00 37.53  ? 477 HOH I O   1 
HETATM 7121 O  O   . HOH P 5 .   ? 41.761  -20.319 31.339  1.00 38.70  ? 478 HOH I O   1 
HETATM 7122 O  O   . HOH P 5 .   ? 53.686  -26.772 20.147  1.00 32.17  ? 479 HOH I O   1 
HETATM 7123 O  O   . HOH P 5 .   ? 34.909  -36.302 48.367  1.00 36.88  ? 480 HOH I O   1 
HETATM 7124 O  O   . HOH P 5 .   ? 59.155  -38.674 36.659  1.00 39.92  ? 481 HOH I O   1 
HETATM 7125 O  O   . HOH P 5 .   ? 25.239  -51.582 37.263  1.00 39.11  ? 482 HOH I O   1 
HETATM 7126 O  O   . HOH P 5 .   ? 8.170   -26.614 50.887  1.00 37.13  ? 483 HOH I O   1 
HETATM 7127 O  O   . HOH P 5 .   ? 26.968  -53.192 38.715  1.00 39.79  ? 484 HOH I O   1 
HETATM 7128 O  O   . HOH P 5 .   ? 41.943  -28.465 37.609  1.00 44.71  ? 485 HOH I O   1 
HETATM 7129 O  O   . HOH P 5 .   ? 22.817  -55.843 53.184  1.00 42.90  ? 486 HOH I O   1 
HETATM 7130 O  O   . HOH P 5 .   ? 52.656  -42.510 46.667  1.00 39.59  ? 487 HOH I O   1 
HETATM 7131 O  O   . HOH P 5 .   ? 33.948  -34.429 46.482  1.00 40.40  ? 488 HOH I O   1 
HETATM 7132 O  O   . HOH P 5 .   ? 17.232  -20.120 58.611  1.00 38.13  ? 489 HOH I O   1 
HETATM 7133 O  O   . HOH P 5 .   ? 30.644  -34.454 54.359  1.00 38.26  ? 490 HOH I O   1 
HETATM 7134 O  O   . HOH P 5 .   ? 25.687  -48.708 37.124  1.00 40.36  ? 491 HOH I O   1 
HETATM 7135 O  O   . HOH P 5 .   ? 25.325  -20.773 54.330  1.00 38.84  ? 492 HOH I O   1 
HETATM 7136 O  O   . HOH P 5 .   ? 28.990  -56.959 46.926  1.00 41.45  ? 493 HOH I O   1 
HETATM 7137 O  O   . HOH P 5 .   ? 51.520  -17.619 33.960  1.00 43.61  ? 494 HOH I O   1 
HETATM 7138 O  O   . HOH P 5 .   ? 52.351  -18.895 35.861  1.00 41.06  ? 495 HOH I O   1 
HETATM 7139 O  O   . HOH P 5 .   ? 27.701  -26.863 58.123  1.00 44.65  ? 496 HOH I O   1 
HETATM 7140 O  O   . HOH P 5 .   ? 32.944  -29.257 45.264  1.00 42.91  ? 497 HOH I O   1 
HETATM 7141 O  O   . HOH P 5 .   ? 59.177  -35.004 16.718  1.00 49.25  ? 498 HOH I O   1 
HETATM 7142 O  O   . HOH P 5 .   ? 5.029   -24.072 53.862  1.00 39.01  ? 499 HOH I O   1 
HETATM 7143 O  O   . HOH P 5 .   ? 61.246  -33.627 30.169  1.00 44.15  ? 500 HOH I O   1 
HETATM 7144 O  O   . HOH P 5 .   ? 35.017  -54.845 43.966  1.00 41.57  ? 501 HOH I O   1 
HETATM 7145 O  O   . HOH P 5 .   ? 38.795  -33.147 32.147  1.00 40.65  ? 502 HOH I O   1 
HETATM 7146 O  O   . HOH P 5 .   ? 41.786  -31.873 44.263  1.00 49.90  ? 503 HOH I O   1 
HETATM 7147 O  O   . HOH P 5 .   ? 56.914  -29.840 45.941  1.00 37.79  ? 504 HOH I O   1 
HETATM 7148 O  O   . HOH P 5 .   ? 27.146  -58.306 45.647  1.00 39.55  ? 505 HOH I O   1 
HETATM 7149 O  O   . HOH P 5 .   ? 11.272  -21.133 58.984  1.00 46.67  ? 506 HOH I O   1 
HETATM 7150 O  O   . HOH P 5 .   ? 22.754  -47.463 37.425  1.00 43.79  ? 507 HOH I O   1 
HETATM 7151 O  O   . HOH P 5 .   ? 19.388  -48.315 39.813  1.00 28.74  ? 508 HOH I O   1 
HETATM 7152 O  O   . HOH P 5 .   ? 29.541  -39.824 33.574  1.00 38.48  ? 509 HOH I O   1 
HETATM 7153 O  O   . HOH P 5 .   ? 9.829   -23.531 46.027  1.00 31.05  ? 510 HOH I O   1 
HETATM 7154 O  O   . HOH P 5 .   ? 55.453  -40.599 44.266  1.00 47.34  ? 511 HOH I O   1 
HETATM 7155 O  O   . HOH P 5 .   ? 17.285  -43.536 34.929  1.00 37.13  ? 512 HOH I O   1 
HETATM 7156 O  O   . HOH P 5 .   ? 42.739  -25.083 32.649  1.00 40.12  ? 513 HOH I O   1 
HETATM 7157 O  O   . HOH P 5 .   ? 44.047  -25.970 34.413  1.00 44.12  ? 514 HOH I O   1 
HETATM 7158 O  O   . HOH P 5 .   ? 41.197  -39.989 44.438  1.00 36.23  ? 515 HOH I O   1 
HETATM 7159 O  O   . HOH P 5 .   ? 30.443  -28.031 51.888  1.00 41.64  ? 516 HOH I O   1 
HETATM 7160 O  O   . HOH P 5 .   ? 64.687  -35.965 24.499  1.00 48.93  ? 517 HOH I O   1 
HETATM 7161 O  O   . HOH P 5 .   ? 46.778  -41.270 53.759  1.00 47.08  ? 518 HOH I O   1 
HETATM 7162 O  O   . HOH P 5 .   ? 45.924  -24.742 36.125  1.00 29.82  ? 519 HOH I O   1 
HETATM 7163 O  O   . HOH P 5 .   ? 24.575  -44.776 59.628  1.00 40.73  ? 520 HOH I O   1 
HETATM 7164 O  O   . HOH P 5 .   ? 23.791  -47.653 58.793  1.00 46.07  ? 521 HOH I O   1 
HETATM 7165 O  O   . HOH P 5 .   ? 7.642   -27.904 58.887  1.00 48.96  ? 522 HOH I O   1 
HETATM 7166 O  O   . HOH P 5 .   ? 30.784  -30.801 45.553  1.00 33.78  ? 523 HOH I O   1 
HETATM 7167 O  O   . HOH P 5 .   ? 7.471   -48.185 45.688  1.00 35.64  ? 524 HOH I O   1 
HETATM 7168 O  O   . HOH P 5 .   ? 37.130  -44.939 39.920  1.00 34.91  ? 525 HOH I O   1 
HETATM 7169 O  O   . HOH P 5 .   ? 14.671  -22.769 42.833  1.00 31.05  ? 526 HOH I O   1 
HETATM 7170 O  O   . HOH P 5 .   ? 34.634  -43.735 38.783  1.00 30.73  ? 527 HOH I O   1 
HETATM 7171 O  O   . HOH P 5 .   ? 19.460  -21.218 38.196  1.00 43.76  ? 528 HOH I O   1 
HETATM 7172 O  O   . HOH P 5 .   ? 39.160  -30.787 31.729  1.00 45.49  ? 529 HOH I O   1 
HETATM 7173 O  O   . HOH P 5 .   ? 32.224  -46.225 55.020  1.00 43.89  ? 530 HOH I O   1 
HETATM 7174 O  O   . HOH P 5 .   ? 5.884   -49.480 47.659  1.00 43.17  ? 531 HOH I O   1 
HETATM 7175 O  O   . HOH P 5 .   ? 6.492   -24.837 55.814  1.00 45.66  ? 532 HOH I O   1 
HETATM 7176 O  O   . HOH P 5 .   ? 6.527   -25.653 49.647  1.00 44.95  ? 533 HOH I O   1 
HETATM 7177 O  O   . HOH P 5 .   ? 29.548  -41.222 56.357  1.00 34.72  ? 534 HOH I O   1 
HETATM 7178 O  O   . HOH P 5 .   ? 30.692  -39.205 54.892  1.00 38.82  ? 535 HOH I O   1 
HETATM 7179 O  O   . HOH P 5 .   ? 55.019  -22.434 39.761  1.00 43.72  ? 536 HOH I O   1 
HETATM 7180 O  O   . HOH P 5 .   ? 56.875  -23.284 38.119  1.00 44.62  ? 537 HOH I O   1 
HETATM 7181 O  O   . HOH P 5 .   ? 38.964  -31.767 36.948  1.00 45.61  ? 538 HOH I O   1 
HETATM 7182 O  O   . HOH P 5 .   ? 38.892  -33.624 38.597  1.00 37.90  ? 539 HOH I O   1 
HETATM 7183 O  O   . HOH P 5 .   ? 63.004  -30.356 20.858  1.00 49.07  ? 540 HOH I O   1 
HETATM 7184 O  O   . HOH P 5 .   ? 33.874  -42.151 54.393  1.00 48.78  ? 541 HOH I O   1 
HETATM 7185 O  O   . HOH P 5 .   ? 39.063  -33.654 44.410  1.00 41.53  ? 542 HOH I O   1 
HETATM 7186 O  O   . HOH P 5 .   ? 44.988  -42.971 27.752  1.00 43.46  ? 543 HOH I O   1 
HETATM 7187 O  O   . HOH P 5 .   ? 46.528  -42.416 29.250  1.00 41.29  ? 544 HOH I O   1 
HETATM 7188 O  O   . HOH P 5 .   ? 41.079  -41.141 51.733  1.00 44.67  ? 545 HOH I O   1 
HETATM 7189 O  O   . HOH P 5 .   ? 47.295  -26.535 42.634  1.00 40.04  ? 546 HOH I O   1 
HETATM 7190 O  O   . HOH P 5 .   ? 35.874  -39.780 45.825  1.00 33.24  ? 547 HOH I O   1 
HETATM 7191 O  O   . HOH P 5 .   ? 40.401  -38.709 37.069  1.00 36.32  ? 548 HOH I O   1 
HETATM 7192 O  O   . HOH P 5 .   ? 45.665  -29.879 46.019  1.00 49.47  ? 549 HOH I O   1 
HETATM 7193 O  O   . HOH P 5 .   ? 35.588  -42.416 34.356  1.00 41.56  ? 550 HOH I O   1 
HETATM 7194 O  O   . HOH P 5 .   ? 51.305  -45.742 39.708  1.00 41.81  ? 551 HOH I O   1 
HETATM 7195 O  O   . HOH P 5 .   ? 52.957  -16.025 32.616  1.00 42.13  ? 552 HOH I O   1 
HETATM 7196 O  O   . HOH P 5 .   ? 34.639  -48.532 39.654  1.00 42.75  ? 553 HOH I O   1 
HETATM 7197 O  O   . HOH P 5 .   ? 26.830  -21.886 57.419  1.00 48.34  ? 554 HOH I O   1 
HETATM 7198 O  O   . HOH P 5 .   ? 24.602  -55.225 42.407  1.00 32.10  ? 555 HOH I O   1 
HETATM 7199 O  O   . HOH P 5 .   ? 17.696  -17.831 46.979  1.00 39.16  ? 556 HOH I O   1 
HETATM 7200 O  O   . HOH P 5 .   ? 17.850  -48.364 56.287  1.00 38.30  ? 557 HOH I O   1 
HETATM 7201 O  O   . HOH P 5 .   ? 36.431  -33.876 29.963  1.00 39.08  ? 558 HOH I O   1 
HETATM 7202 O  O   . HOH P 5 .   ? 21.999  -47.649 31.637  1.00 37.75  ? 559 HOH I O   1 
HETATM 7203 O  O   . HOH P 5 .   ? 48.101  -47.615 34.023  1.00 24.12  ? 560 HOH I O   1 
HETATM 7204 O  O   . HOH P 5 .   ? 67.118  -33.610 27.013  1.00 37.26  ? 561 HOH I O   1 
HETATM 7205 O  O   . HOH P 5 .   ? 55.545  -39.985 40.648  1.00 30.15  ? 562 HOH I O   1 
HETATM 7206 O  O   . HOH P 5 .   ? 20.707  -20.128 58.242  1.00 33.76  ? 563 HOH I O   1 
HETATM 7207 O  O   . HOH P 5 .   ? 25.447  -21.551 41.742  1.00 35.73  ? 564 HOH I O   1 
HETATM 7208 O  O   . HOH P 5 .   ? 29.432  -24.955 44.979  1.00 38.97  ? 565 HOH I O   1 
HETATM 7209 O  O   . HOH P 5 .   ? 28.574  -29.082 56.455  1.00 45.73  ? 566 HOH I O   1 
HETATM 7210 O  O   . HOH P 5 .   ? 23.237  -20.071 40.124  1.00 44.06  ? 567 HOH I O   1 
HETATM 7211 O  O   . HOH P 5 .   ? 23.448  -17.171 38.327  1.00 49.59  ? 568 HOH I O   1 
HETATM 7212 O  O   . HOH P 5 .   ? 34.720  -36.709 28.681  1.00 45.35  ? 569 HOH I O   1 
HETATM 7213 O  O   . HOH P 5 .   ? 35.504  -36.433 31.199  1.00 46.85  ? 570 HOH I O   1 
HETATM 7214 O  O   . HOH P 5 .   ? 22.150  -23.727 59.441  1.00 30.31  ? 571 HOH I O   1 
HETATM 7215 O  O   . HOH P 5 .   ? 17.882  -50.076 39.493  1.00 38.89  ? 572 HOH I O   1 
HETATM 7216 O  O   . HOH P 5 .   ? 29.712  -29.428 55.090  1.00 53.74  ? 573 HOH I O   1 
HETATM 7217 O  O   . HOH P 5 .   ? 33.231  -56.204 51.734  1.00 45.17  ? 574 HOH I O   1 
HETATM 7218 O  O   . HOH P 5 .   ? 19.212  -50.407 41.281  1.00 42.17  ? 575 HOH I O   1 
HETATM 7219 O  O   . HOH P 5 .   ? 34.336  -49.345 53.704  1.00 37.23  ? 576 HOH I O   1 
HETATM 7220 O  O   . HOH P 5 .   ? 8.791   -27.115 47.930  1.00 42.76  ? 577 HOH I O   1 
HETATM 7221 O  O   . HOH P 5 .   ? 25.322  -26.805 59.695  1.00 39.69  ? 578 HOH I O   1 
HETATM 7222 O  O   . HOH P 5 .   ? 27.920  -30.937 58.114  1.00 47.27  ? 579 HOH I O   1 
HETATM 7223 O  O   . HOH P 5 .   ? 63.393  -34.216 26.452  1.00 46.66  ? 580 HOH I O   1 
HETATM 7224 O  O   . HOH P 5 .   ? 37.611  -48.148 40.854  1.00 44.02  ? 581 HOH I O   1 
HETATM 7225 O  O   . HOH P 5 .   ? 65.762  -35.173 27.879  1.00 47.37  ? 582 HOH I O   1 
HETATM 7226 O  O   . HOH P 5 .   ? 65.510  -34.022 17.696  1.00 51.05  ? 583 HOH I O   1 
HETATM 7227 O  O   . HOH P 5 .   ? 13.433  -51.138 47.843  1.00 41.18  ? 584 HOH I O   1 
HETATM 7228 O  O   . HOH P 5 .   ? 32.808  -25.977 44.964  1.00 51.54  ? 585 HOH I O   1 
HETATM 7229 O  O   . HOH P 5 .   ? 34.436  -34.801 53.043  1.00 50.01  ? 586 HOH I O   1 
HETATM 7230 O  O   . HOH P 5 .   ? 9.496   -26.288 60.682  1.00 48.61  ? 587 HOH I O   1 
HETATM 7231 O  O   . HOH P 5 .   ? 37.990  -40.523 45.346  1.00 41.74  ? 588 HOH I O   1 
HETATM 7232 O  O   . HOH P 5 .   ? 47.429  -50.435 34.538  1.00 43.55  ? 589 HOH I O   1 
HETATM 7233 O  O   . HOH P 5 .   ? 23.443  -19.256 54.864  1.00 48.50  ? 590 HOH I O   1 
HETATM 7234 O  O   . HOH P 5 .   ? 18.310  -50.765 45.475  1.00 33.13  ? 591 HOH I O   1 
HETATM 7235 O  O   . HOH P 5 .   ? 38.189  -40.287 47.196  1.00 47.70  ? 592 HOH I O   1 
HETATM 7236 O  O   . HOH P 5 .   ? 18.336  -52.831 44.768  1.00 39.10  ? 593 HOH I O   1 
HETATM 7237 O  O   . HOH P 5 .   ? 39.967  -55.113 33.812  1.00 47.85  ? 594 HOH I O   1 
HETATM 7238 O  O   . HOH P 5 .   ? 29.230  -44.277 57.984  1.00 46.44  ? 595 HOH I O   1 
HETATM 7239 O  O   . HOH P 5 .   ? 26.588  -43.455 57.454  1.00 37.74  ? 596 HOH I O   1 
HETATM 7240 O  O   . HOH P 5 .   ? 28.229  -24.815 43.231  1.00 42.54  ? 597 HOH I O   1 
HETATM 7241 O  O   . HOH P 5 .   ? 14.973  -51.644 49.106  1.00 50.63  ? 598 HOH I O   1 
HETATM 7242 O  O   . HOH P 5 .   ? 33.735  -33.120 43.050  1.00 48.93  ? 599 HOH I O   1 
HETATM 7243 O  O   . HOH Q 5 .   ? 4.314   -31.321 44.660  1.00 36.46  ? 401 HOH Q O   1 
HETATM 7244 O  O   . HOH Q 5 .   ? 4.620   -29.016 40.636  1.00 33.30  ? 402 HOH Q O   1 
HETATM 7245 O  O   . HOH Q 5 .   ? 2.893   -35.536 51.743  1.00 40.97  ? 403 HOH Q O   1 
HETATM 7246 O  O   . HOH Q 5 .   ? 3.810   -29.844 43.111  1.00 40.80  ? 404 HOH Q O   1 
HETATM 7247 O  O   . HOH Q 5 .   ? -4.054  -30.666 48.528  1.00 46.28  ? 405 HOH Q O   1 
HETATM 7248 O  O   . HOH Q 5 .   ? 4.972   -17.069 47.319  1.00 49.11  ? 406 HOH Q O   1 
HETATM 7249 O  O   . HOH Q 5 .   ? 2.479   -17.048 48.002  1.00 46.24  ? 407 HOH Q O   1 
HETATM 7250 O  O   . HOH Q 5 .   ? 6.192   -18.571 45.784  1.00 57.01  ? 408 HOH Q O   1 
HETATM 7251 O  O   . HOH Q 5 .   ? 0.235   -37.283 46.633  1.00 38.92  ? 409 HOH Q O   1 
HETATM 7252 O  O   . HOH Q 5 .   ? 12.040  -20.964 44.405  1.00 46.53  ? 410 HOH Q O   1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   2   2   GLN GLN L . n 
A 1 2   VAL 2   3   3   VAL VAL L . n 
A 1 3   LEU 3   4   4   LEU LEU L . n 
A 1 4   THR 4   5   5   THR THR L . n 
A 1 5   GLN 5   6   6   GLN GLN L . n 
A 1 6   THR 6   7   7   THR THR L . n 
A 1 7   PRO 7   8   8   PRO PRO L . n 
A 1 8   SER 8   9   9   SER SER L . n 
A 1 9   SER 9   10  10  SER SER L . n 
A 1 10  VAL 10  11  11  VAL VAL L . n 
A 1 11  SER 11  12  12  SER SER L . n 
A 1 12  THR 12  13  13  THR THR L . n 
A 1 13  ALA 13  14  14  ALA ALA L . n 
A 1 14  VAL 14  15  15  VAL VAL L . n 
A 1 15  GLY 15  16  16  GLY GLY L . n 
A 1 16  SER 16  17  17  SER SER L . n 
A 1 17  ALA 17  18  18  ALA ALA L . n 
A 1 18  VAL 18  19  19  VAL VAL L . n 
A 1 19  THR 19  20  20  THR THR L . n 
A 1 20  ILE 20  21  21  ILE ILE L . n 
A 1 21  ASN 21  22  22  ASN ASN L . n 
A 1 22  CYS 22  23  23  CYS CYS L . n 
A 1 23  GLN 23  24  24  GLN GLN L . n 
A 1 24  SER 24  25  25  SER SER L . n 
A 1 25  SER 25  26  26  SER SER L . n 
A 1 26  GLN 26  27  27  GLN GLN L . n 
A 1 27  ASN 27  27  27  ASN ASN L A n 
A 1 28  VAL 28  27  27  VAL VAL L B n 
A 1 29  TYR 29  28  28  TYR TYR L . n 
A 1 30  SER 30  29  29  SER SER L . n 
A 1 31  ASN 31  30  30  ASN ASN L . n 
A 1 32  ASN 32  31  31  ASN ASN L . n 
A 1 33  ASN 33  32  32  ASN ASN L . n 
A 1 34  LEU 34  33  33  LEU LEU L . n 
A 1 35  ALA 35  34  34  ALA ALA L . n 
A 1 36  TRP 36  35  35  TRP TRP L . n 
A 1 37  PHE 37  36  36  PHE PHE L . n 
A 1 38  GLN 38  37  37  GLN GLN L . n 
A 1 39  GLN 39  38  38  GLN GLN L . n 
A 1 40  LYS 40  39  39  LYS LYS L . n 
A 1 41  PRO 41  40  40  PRO PRO L . n 
A 1 42  GLY 42  41  41  GLY GLY L . n 
A 1 43  GLN 43  42  42  GLN GLN L . n 
A 1 44  PRO 44  43  43  PRO PRO L . n 
A 1 45  PRO 45  44  44  PRO PRO L . n 
A 1 46  ARG 46  45  45  ARG ARG L . n 
A 1 47  LEU 47  46  46  LEU LEU L . n 
A 1 48  LEU 48  47  47  LEU LEU L . n 
A 1 49  ILE 49  48  48  ILE ILE L . n 
A 1 50  TYR 50  49  49  TYR TYR L . n 
A 1 51  ASP 51  50  50  ASP ASP L . n 
A 1 52  ALA 52  51  51  ALA ALA L . n 
A 1 53  SER 53  52  52  SER SER L . n 
A 1 54  LYS 54  53  53  LYS LYS L . n 
A 1 55  LEU 55  54  54  LEU LEU L . n 
A 1 56  ALA 56  55  55  ALA ALA L . n 
A 1 57  SER 57  56  56  SER SER L . n 
A 1 58  GLY 58  57  57  GLY GLY L . n 
A 1 59  VAL 59  58  58  VAL VAL L . n 
A 1 60  PRO 60  59  59  PRO PRO L . n 
A 1 61  SER 61  60  60  SER SER L . n 
A 1 62  ARG 62  61  61  ARG ARG L . n 
A 1 63  PHE 63  62  62  PHE PHE L . n 
A 1 64  LYS 64  63  63  LYS LYS L . n 
A 1 65  GLY 65  64  64  GLY GLY L . n 
A 1 66  SER 66  65  65  SER SER L . n 
A 1 67  GLY 67  66  66  GLY GLY L . n 
A 1 68  SER 68  67  67  SER SER L . n 
A 1 69  GLY 69  68  68  GLY GLY L . n 
A 1 70  THR 70  69  69  THR THR L . n 
A 1 71  GLN 71  70  70  GLN GLN L . n 
A 1 72  PHE 72  71  71  PHE PHE L . n 
A 1 73  THR 73  72  72  THR THR L . n 
A 1 74  PHE 74  73  73  PHE PHE L . n 
A 1 75  THR 75  74  74  THR THR L . n 
A 1 76  ILE 76  75  75  ILE ILE L . n 
A 1 77  SER 77  76  76  SER SER L . n 
A 1 78  ASP 78  77  77  ASP ASP L . n 
A 1 79  VAL 79  78  78  VAL VAL L . n 
A 1 80  GLN 80  79  79  GLN GLN L . n 
A 1 81  CYS 81  80  80  CYS CYS L . n 
A 1 82  ASP 82  81  81  ASP ASP L . n 
A 1 83  ASP 83  82  82  ASP ASP L . n 
A 1 84  ALA 84  83  83  ALA ALA L . n 
A 1 85  ALA 85  84  84  ALA ALA L . n 
A 1 86  THR 86  85  85  THR THR L . n 
A 1 87  PHE 87  86  86  PHE PHE L . n 
A 1 88  TYR 88  87  87  TYR TYR L . n 
A 1 89  CYS 89  88  88  CYS CYS L . n 
A 1 90  LEU 90  89  89  LEU LEU L . n 
A 1 91  GLY 91  90  90  GLY GLY L . n 
A 1 92  GLY 92  91  91  GLY GLY L . n 
A 1 93  TYR 93  92  92  TYR TYR L . n 
A 1 94  ASP 94  93  93  ASP ASP L . n 
A 1 95  CYS 95  94  94  CYS CYS L . n 
A 1 96  SER 96  95  95  SER SER L . n 
A 1 97  SER 97  95  95  SER SER L A n 
A 1 98  GLY 98  95  95  GLY GLY L B n 
A 1 99  ASP 99  95  95  ASP ASP L C n 
A 1 100 CYS 100 95  95  CYS CYS L D n 
A 1 101 ALA 101 96  96  ALA ALA L . n 
A 1 102 ALA 102 97  97  ALA ALA L . n 
A 1 103 PHE 103 98  98  PHE PHE L . n 
A 1 104 GLY 104 99  99  GLY GLY L . n 
A 1 105 GLY 105 100 100 GLY GLY L . n 
A 1 106 GLY 106 101 101 GLY GLY L . n 
A 1 107 THR 107 102 102 THR THR L . n 
A 1 108 GLU 108 103 103 GLU GLU L . n 
A 1 109 VAL 109 104 104 VAL VAL L . n 
A 1 110 VAL 110 105 105 VAL VAL L . n 
A 1 111 VAL 111 106 106 VAL VAL L . n 
A 1 112 ARG 112 107 107 ARG ARG L . n 
A 1 113 GLY 113 108 108 GLY GLY L . n 
A 1 114 ASP 114 109 109 ASP ASP L . n 
A 1 115 PRO 115 110 110 PRO PRO L . n 
A 1 116 VAL 116 111 111 VAL VAL L . n 
A 1 117 ALA 117 112 112 ALA ALA L . n 
A 1 118 PRO 118 113 113 PRO PRO L . n 
A 1 119 THR 119 114 114 THR THR L . n 
A 1 120 VAL 120 115 115 VAL VAL L . n 
A 1 121 LEU 121 116 116 LEU LEU L . n 
A 1 122 ILE 122 117 117 ILE ILE L . n 
A 1 123 PHE 123 118 118 PHE PHE L . n 
A 1 124 PRO 124 119 119 PRO PRO L . n 
A 1 125 PRO 125 120 120 PRO PRO L . n 
A 1 126 ALA 126 121 121 ALA ALA L . n 
A 1 127 ALA 127 122 122 ALA ALA L . n 
A 1 128 ASP 128 123 123 ASP ASP L . n 
A 1 129 GLN 129 124 124 GLN GLN L . n 
A 1 130 VAL 130 125 125 VAL VAL L . n 
A 1 131 ALA 131 126 126 ALA ALA L . n 
A 1 132 THR 132 127 127 THR THR L . n 
A 1 133 GLY 133 128 128 GLY GLY L . n 
A 1 134 THR 134 129 129 THR THR L . n 
A 1 135 VAL 135 130 130 VAL VAL L . n 
A 1 136 THR 136 131 131 THR THR L . n 
A 1 137 ILE 137 132 132 ILE ILE L . n 
A 1 138 VAL 138 133 133 VAL VAL L . n 
A 1 139 CYS 139 134 134 CYS CYS L . n 
A 1 140 VAL 140 135 135 VAL VAL L . n 
A 1 141 ALA 141 136 136 ALA ALA L . n 
A 1 142 ASN 142 137 137 ASN ASN L . n 
A 1 143 LYS 143 138 138 LYS LYS L . n 
A 1 144 TYR 144 139 139 TYR TYR L . n 
A 1 145 PHE 145 140 140 PHE PHE L . n 
A 1 146 PRO 146 141 141 PRO PRO L . n 
A 1 147 ASP 147 142 142 ASP ASP L . n 
A 1 148 VAL 148 143 143 VAL VAL L . n 
A 1 149 THR 149 144 144 THR THR L . n 
A 1 150 VAL 150 145 145 VAL VAL L . n 
A 1 151 THR 151 146 146 THR THR L . n 
A 1 152 TRP 152 147 147 TRP TRP L . n 
A 1 153 GLU 153 148 148 GLU GLU L . n 
A 1 154 VAL 154 149 149 VAL VAL L . n 
A 1 155 ASP 155 150 150 ASP ASP L . n 
A 1 156 GLY 156 151 151 GLY GLY L . n 
A 1 157 THR 157 152 152 THR THR L . n 
A 1 158 THR 158 153 153 THR THR L . n 
A 1 159 GLN 159 154 154 GLN GLN L . n 
A 1 160 THR 160 155 155 THR THR L . n 
A 1 161 THR 161 156 156 THR THR L . n 
A 1 162 GLY 162 157 157 GLY GLY L . n 
A 1 163 ILE 163 158 158 ILE ILE L . n 
A 1 164 GLU 164 159 159 GLU GLU L . n 
A 1 165 ASN 165 160 160 ASN ASN L . n 
A 1 166 SER 166 161 161 SER SER L . n 
A 1 167 LYS 167 162 162 LYS LYS L . n 
A 1 168 THR 168 163 163 THR THR L . n 
A 1 169 PRO 169 164 164 PRO PRO L . n 
A 1 170 GLN 170 165 165 GLN GLN L . n 
A 1 171 ASN 171 166 166 ASN ASN L . n 
A 1 172 SER 172 167 167 SER SER L . n 
A 1 173 ALA 173 168 168 ALA ALA L . n 
A 1 174 ASP 174 169 169 ASP ASP L . n 
A 1 175 CYS 175 170 170 CYS CYS L . n 
A 1 176 THR 176 171 171 THR THR L . n 
A 1 177 TYR 177 172 172 TYR TYR L . n 
A 1 178 ASN 178 173 173 ASN ASN L . n 
A 1 179 LEU 179 174 174 LEU LEU L . n 
A 1 180 SER 180 175 175 SER SER L . n 
A 1 181 SER 181 176 176 SER SER L . n 
A 1 182 THR 182 177 177 THR THR L . n 
A 1 183 LEU 183 178 178 LEU LEU L . n 
A 1 184 THR 184 179 179 THR THR L . n 
A 1 185 LEU 185 180 180 LEU LEU L . n 
A 1 186 THR 186 181 181 THR THR L . n 
A 1 187 SER 187 182 182 SER SER L . n 
A 1 188 THR 188 183 183 THR THR L . n 
A 1 189 GLN 189 184 184 GLN GLN L . n 
A 1 190 TYR 190 185 185 TYR TYR L . n 
A 1 191 ASN 191 186 186 ASN ASN L . n 
A 1 192 SER 192 187 187 SER SER L . n 
A 1 193 HIS 193 188 188 HIS HIS L . n 
A 1 194 LYS 194 189 189 LYS LYS L . n 
A 1 195 GLU 195 190 190 GLU GLU L . n 
A 1 196 TYR 196 191 191 TYR TYR L . n 
A 1 197 THR 197 192 192 THR THR L . n 
A 1 198 CYS 198 193 193 CYS CYS L . n 
A 1 199 LYS 199 194 194 LYS LYS L . n 
A 1 200 VAL 200 195 195 VAL VAL L . n 
A 1 201 THR 201 196 196 THR THR L . n 
A 1 202 GLN 202 197 197 GLN GLN L . n 
A 1 203 GLY 203 198 198 GLY GLY L . n 
A 1 204 THR 204 199 199 THR THR L . n 
A 1 205 THR 205 200 200 THR THR L . n 
A 1 206 SER 206 201 201 SER SER L . n 
A 1 207 VAL 207 202 202 VAL VAL L . n 
A 1 208 VAL 208 203 203 VAL VAL L . n 
A 1 209 GLN 209 204 204 GLN GLN L . n 
A 1 210 SER 210 205 205 SER SER L . n 
A 1 211 PHE 211 206 206 PHE PHE L . n 
A 1 212 ASN 212 207 207 ASN ASN L . n 
A 1 213 ARG 213 208 208 ARG ARG L . n 
A 1 214 GLY 214 209 209 GLY GLY L . n 
A 1 215 ASP 215 210 210 ASP ASP L . n 
A 1 216 CYS 216 211 211 CYS CYS L . n 
B 2 1   GLN 1   2   2   GLN GLN H . n 
B 2 2   SER 2   3   3   SER SER H . n 
B 2 3   LEU 3   4   4   LEU LEU H . n 
B 2 4   GLU 4   5   5   GLU GLU H . n 
B 2 5   GLU 5   6   6   GLU GLU H . n 
B 2 6   SER 6   7   7   SER SER H . n 
B 2 7   GLY 7   8   8   GLY GLY H . n 
B 2 8   GLY 8   9   9   GLY GLY H . n 
B 2 9   ASP 9   10  10  ASP ASP H . n 
B 2 10  LEU 10  11  11  LEU LEU H . n 
B 2 11  VAL 11  12  12  VAL VAL H . n 
B 2 12  GLN 12  13  13  GLN GLN H . n 
B 2 13  PRO 13  14  14  PRO PRO H . n 
B 2 14  GLY 14  15  15  GLY GLY H . n 
B 2 15  ALA 15  16  16  ALA ALA H . n 
B 2 16  SER 16  17  17  SER SER H . n 
B 2 17  LEU 17  18  18  LEU LEU H . n 
B 2 18  THR 18  19  19  THR THR H . n 
B 2 19  LEU 19  20  20  LEU LEU H . n 
B 2 20  THR 20  21  21  THR THR H . n 
B 2 21  CYS 21  22  22  CYS CYS H . n 
B 2 22  LYS 22  23  23  LYS LYS H . n 
B 2 23  ALA 23  24  24  ALA ALA H . n 
B 2 24  SER 24  25  25  SER SER H . n 
B 2 25  GLY 25  26  26  GLY GLY H . n 
B 2 26  PHE 26  27  27  PHE PHE H . n 
B 2 27  SER 27  28  28  SER SER H . n 
B 2 28  PHE 28  29  29  PHE PHE H . n 
B 2 29  GLY 29  30  30  GLY GLY H . n 
B 2 30  ASN 30  31  31  ASN ASN H . n 
B 2 31  ASN 31  32  32  ASN ASN H . n 
B 2 32  TYR 32  33  33  TYR TYR H . n 
B 2 33  ASP 33  34  34  ASP ASP H . n 
B 2 34  MET 34  35  35  MET MET H . n 
B 2 35  CYS 35  35  35  CYS CYS H A n 
B 2 36  TRP 36  36  36  TRP TRP H . n 
B 2 37  VAL 37  37  37  VAL VAL H . n 
B 2 38  ARG 38  38  38  ARG ARG H . n 
B 2 39  GLN 39  39  39  GLN GLN H . n 
B 2 40  ALA 40  40  40  ALA ALA H . n 
B 2 41  PRO 41  41  41  PRO PRO H . n 
B 2 42  GLY 42  42  42  GLY GLY H . n 
B 2 43  LYS 43  43  43  LYS LYS H . n 
B 2 44  GLY 44  44  44  GLY GLY H . n 
B 2 45  LEU 45  45  45  LEU LEU H . n 
B 2 46  GLU 46  46  46  GLU GLU H . n 
B 2 47  TRP 47  47  47  TRP TRP H . n 
B 2 48  ILE 48  48  48  ILE ILE H . n 
B 2 49  GLY 49  49  49  GLY GLY H . n 
B 2 50  CYS 50  50  50  CYS CYS H . n 
B 2 51  ILE 51  51  51  ILE ILE H . n 
B 2 52  GLU 52  52  52  GLU GLU H . n 
B 2 53  THR 53  52  52  THR THR H A n 
B 2 54  GLY 54  52  52  GLY GLY H B n 
B 2 55  SER 55  53  53  SER SER H . n 
B 2 56  SER 56  54  54  SER SER H . n 
B 2 57  ASP 57  55  55  ASP ASP H . n 
B 2 58  SER 58  56  56  SER SER H . n 
B 2 59  ALA 59  57  57  ALA ALA H . n 
B 2 60  ALA 60  58  58  ALA ALA H . n 
B 2 61  TYR 61  59  59  TYR TYR H . n 
B 2 62  ALA 62  60  60  ALA ALA H . n 
B 2 63  THR 63  61  61  THR THR H . n 
B 2 64  TRP 64  62  62  TRP TRP H . n 
B 2 65  ALA 65  63  63  ALA ALA H . n 
B 2 66  LYS 66  64  64  LYS LYS H . n 
B 2 67  GLY 67  65  65  GLY GLY H . n 
B 2 68  ARG 68  66  66  ARG ARG H . n 
B 2 69  PHE 69  67  67  PHE PHE H . n 
B 2 70  THR 70  68  68  THR THR H . n 
B 2 71  ILE 71  69  69  ILE ILE H . n 
B 2 72  SER 72  70  70  SER SER H . n 
B 2 73  LYS 73  71  71  LYS LYS H . n 
B 2 74  THR 74  72  72  THR THR H . n 
B 2 75  SER 75  73  73  SER SER H . n 
B 2 76  SER 76  74  74  SER SER H . n 
B 2 77  THR 77  75  75  THR THR H . n 
B 2 78  THR 78  76  76  THR THR H . n 
B 2 79  VAL 79  77  77  VAL VAL H . n 
B 2 80  THR 80  78  78  THR THR H . n 
B 2 81  LEU 81  79  79  LEU LEU H . n 
B 2 82  GLN 82  80  80  GLN GLN H . n 
B 2 83  MET 83  81  81  MET MET H . n 
B 2 84  THR 84  82  82  THR THR H . n 
B 2 85  SER 85  82  82  SER SER H A n 
B 2 86  LEU 86  82  82  LEU LEU H B n 
B 2 87  THR 87  83  83  THR THR H . n 
B 2 88  ALA 88  84  84  ALA ALA H . n 
B 2 89  ALA 89  85  85  ALA ALA H . n 
B 2 90  ASP 90  86  86  ASP ASP H . n 
B 2 91  THR 91  87  87  THR THR H . n 
B 2 92  ALA 92  88  88  ALA ALA H . n 
B 2 93  THR 93  89  89  THR THR H . n 
B 2 94  TYR 94  90  90  TYR TYR H . n 
B 2 95  PHE 95  91  91  PHE PHE H . n 
B 2 96  CYS 96  92  92  CYS CYS H . n 
B 2 97  ALA 97  93  93  ALA ALA H . n 
B 2 98  ARG 98  94  94  ARG ARG H . n 
B 2 99  ASN 99  95  95  ASN ASN H . n 
B 2 100 PHE 100 96  96  PHE PHE H . n 
B 2 101 ASP 101 101 101 ASP ASP H . n 
B 2 102 LEU 102 102 102 LEU LEU H . n 
B 2 103 TRP 103 103 103 TRP TRP H . n 
B 2 104 GLY 104 104 104 GLY GLY H . n 
B 2 105 PRO 105 105 105 PRO PRO H . n 
B 2 106 GLY 106 106 106 GLY GLY H . n 
B 2 107 THR 107 107 107 THR THR H . n 
B 2 108 LEU 108 108 108 LEU LEU H . n 
B 2 109 VAL 109 109 109 VAL VAL H . n 
B 2 110 ILE 110 110 110 ILE ILE H . n 
B 2 111 VAL 111 111 111 VAL VAL H . n 
B 2 112 SER 112 112 112 SER SER H . n 
B 2 113 SER 113 113 113 SER SER H . n 
B 2 114 GLY 114 114 114 GLY GLY H . n 
B 2 115 GLN 115 115 115 GLN GLN H . n 
B 2 116 PRO 116 116 116 PRO PRO H . n 
B 2 117 LYS 117 117 117 LYS LYS H . n 
B 2 118 ALA 118 118 118 ALA ALA H . n 
B 2 119 PRO 119 119 119 PRO PRO H . n 
B 2 120 SER 120 120 120 SER SER H . n 
B 2 121 VAL 121 121 121 VAL VAL H . n 
B 2 122 PHE 122 122 122 PHE PHE H . n 
B 2 123 PRO 123 123 123 PRO PRO H . n 
B 2 124 LEU 124 124 124 LEU LEU H . n 
B 2 125 ALA 125 125 125 ALA ALA H . n 
B 2 126 PRO 126 126 126 PRO PRO H . n 
B 2 127 CYS 127 127 127 CYS CYS H . n 
B 2 128 CYS 128 128 128 CYS CYS H . n 
B 2 129 GLY 129 129 129 GLY GLY H . n 
B 2 130 ASP 130 130 130 ASP ASP H . n 
B 2 131 THR 131 131 131 THR THR H . n 
B 2 132 PRO 132 132 132 PRO PRO H . n 
B 2 133 SER 133 133 133 SER SER H . n 
B 2 134 SER 134 134 134 SER SER H . n 
B 2 135 THR 135 135 135 THR THR H . n 
B 2 136 VAL 136 136 136 VAL VAL H . n 
B 2 137 THR 137 137 137 THR THR H . n 
B 2 138 LEU 138 138 138 LEU LEU H . n 
B 2 139 GLY 139 139 139 GLY GLY H . n 
B 2 140 CYS 140 140 140 CYS CYS H . n 
B 2 141 LEU 141 141 141 LEU LEU H . n 
B 2 142 VAL 142 142 142 VAL VAL H . n 
B 2 143 LYS 143 143 143 LYS LYS H . n 
B 2 144 GLY 144 144 144 GLY GLY H . n 
B 2 145 TYR 145 145 145 TYR TYR H . n 
B 2 146 LEU 146 146 146 LEU LEU H . n 
B 2 147 PRO 147 147 147 PRO PRO H . n 
B 2 148 GLU 148 148 148 GLU GLU H . n 
B 2 149 PRO 149 149 149 PRO PRO H . n 
B 2 150 VAL 150 150 150 VAL VAL H . n 
B 2 151 THR 151 151 151 THR THR H . n 
B 2 152 VAL 152 152 152 VAL VAL H . n 
B 2 153 THR 153 153 153 THR THR H . n 
B 2 154 TRP 154 154 154 TRP TRP H . n 
B 2 155 ASN 155 155 155 ASN ASN H . n 
B 2 156 SER 156 156 156 SER SER H . n 
B 2 157 GLY 157 157 157 GLY GLY H . n 
B 2 158 THR 158 158 158 THR THR H . n 
B 2 159 LEU 159 159 159 LEU LEU H . n 
B 2 160 THR 160 160 160 THR THR H . n 
B 2 161 ASN 161 161 161 ASN ASN H . n 
B 2 162 GLY 162 162 162 GLY GLY H . n 
B 2 163 VAL 163 163 163 VAL VAL H . n 
B 2 164 ARG 164 164 164 ARG ARG H . n 
B 2 165 THR 165 165 165 THR THR H . n 
B 2 166 PHE 166 166 166 PHE PHE H . n 
B 2 167 PRO 167 167 167 PRO PRO H . n 
B 2 168 SER 168 168 168 SER SER H . n 
B 2 169 VAL 169 169 169 VAL VAL H . n 
B 2 170 ARG 170 170 170 ARG ARG H . n 
B 2 171 GLN 171 171 171 GLN GLN H . n 
B 2 172 SER 172 172 172 SER SER H . n 
B 2 173 SER 173 173 173 SER SER H . n 
B 2 174 GLY 174 174 174 GLY GLY H . n 
B 2 175 LEU 175 175 175 LEU LEU H . n 
B 2 176 TYR 176 176 176 TYR TYR H . n 
B 2 177 SER 177 177 177 SER SER H . n 
B 2 178 LEU 178 178 178 LEU LEU H . n 
B 2 179 SER 179 179 179 SER SER H . n 
B 2 180 SER 180 180 180 SER SER H . n 
B 2 181 VAL 181 181 181 VAL VAL H . n 
B 2 182 VAL 182 182 182 VAL VAL H . n 
B 2 183 SER 183 183 183 SER SER H . n 
B 2 184 VAL 184 184 184 VAL VAL H . n 
B 2 185 THR 185 185 185 THR THR H . n 
B 2 186 SER 186 186 186 SER SER H . n 
B 2 187 SER 187 187 187 SER SER H . n 
B 2 188 SER 188 188 188 SER SER H . n 
B 2 189 GLN 189 189 189 GLN GLN H . n 
B 2 190 PRO 190 190 190 PRO PRO H . n 
B 2 191 VAL 191 191 191 VAL VAL H . n 
B 2 192 THR 192 192 192 THR THR H . n 
B 2 193 CYS 193 193 193 CYS CYS H . n 
B 2 194 ASN 194 194 194 ASN ASN H . n 
B 2 195 VAL 195 195 195 VAL VAL H . n 
B 2 196 ALA 196 196 196 ALA ALA H . n 
B 2 197 HIS 197 197 197 HIS HIS H . n 
B 2 198 PRO 198 198 198 PRO PRO H . n 
B 2 199 ALA 199 199 199 ALA ALA H . n 
B 2 200 THR 200 200 200 THR THR H . n 
B 2 201 ASN 201 201 201 ASN ASN H . n 
B 2 202 THR 202 202 202 THR THR H . n 
B 2 203 LYS 203 203 203 LYS LYS H . n 
B 2 204 VAL 204 204 204 VAL VAL H . n 
B 2 205 ASP 205 205 205 ASP ASP H . n 
B 2 206 LYS 206 206 206 LYS LYS H . n 
B 2 207 THR 207 207 207 THR THR H . n 
B 2 208 VAL 208 208 208 VAL VAL H . n 
B 2 209 ALA 209 209 209 ALA ALA H . n 
B 2 210 PRO 210 210 210 PRO PRO H . n 
B 2 211 SER 211 211 211 SER SER H . n 
B 2 212 THR 212 212 212 THR THR H . n 
B 2 213 CYS 213 213 213 CYS CYS H . n 
C 3 1   ASN 1   301 ?   ?   ?   P . n 
C 3 2   ASN 2   302 ?   ?   ?   P . n 
C 3 3   THR 3   303 303 THR THR P . n 
C 3 4   ARG 4   304 304 ARG ARG P . n 
C 3 5   LYS 5   305 305 LYS LYS P . n 
C 3 6   SER 6   306 306 SER SER P . n 
C 3 7   ILE 7   307 307 ILE ILE P . n 
C 3 8   HIS 8   308 308 HIS HIS P . n 
C 3 9   ILE 9   309 309 ILE ILE P . n 
C 3 10  GLY 10  312 312 GLY GLY P . n 
C 3 11  PRO 11  313 313 PRO PRO P . n 
C 3 12  GLY 12  314 314 GLY GLY P . n 
C 3 13  ARG 13  315 ?   ?   ?   P . n 
C 3 14  ALA 14  316 ?   ?   ?   P . n 
C 3 15  PHE 15  317 ?   ?   ?   P . n 
C 3 16  TYR 16  318 ?   ?   ?   P . n 
C 3 17  THR 17  319 ?   ?   ?   P . n 
C 3 18  THR 18  320 ?   ?   ?   P . n 
C 3 19  GLY 19  321 ?   ?   ?   P . n 
C 3 20  GLU 20  322 ?   ?   ?   P . n 
C 3 21  ILE 21  323 ?   ?   ?   P . n 
C 3 22  ILE 22  324 ?   ?   ?   P . n 
C 3 23  GLY 23  325 ?   ?   ?   P . n 
D 1 1   GLN 1   2   2   GLN GLN M . n 
D 1 2   VAL 2   3   3   VAL VAL M . n 
D 1 3   LEU 3   4   4   LEU LEU M . n 
D 1 4   THR 4   5   5   THR THR M . n 
D 1 5   GLN 5   6   6   GLN GLN M . n 
D 1 6   THR 6   7   7   THR THR M . n 
D 1 7   PRO 7   8   8   PRO PRO M . n 
D 1 8   SER 8   9   9   SER SER M . n 
D 1 9   SER 9   10  10  SER SER M . n 
D 1 10  VAL 10  11  11  VAL VAL M . n 
D 1 11  SER 11  12  12  SER SER M . n 
D 1 12  THR 12  13  13  THR THR M . n 
D 1 13  ALA 13  14  14  ALA ALA M . n 
D 1 14  VAL 14  15  15  VAL VAL M . n 
D 1 15  GLY 15  16  16  GLY GLY M . n 
D 1 16  SER 16  17  17  SER SER M . n 
D 1 17  ALA 17  18  18  ALA ALA M . n 
D 1 18  VAL 18  19  19  VAL VAL M . n 
D 1 19  THR 19  20  20  THR THR M . n 
D 1 20  ILE 20  21  21  ILE ILE M . n 
D 1 21  ASN 21  22  22  ASN ASN M . n 
D 1 22  CYS 22  23  23  CYS CYS M . n 
D 1 23  GLN 23  24  24  GLN GLN M . n 
D 1 24  SER 24  25  25  SER SER M . n 
D 1 25  SER 25  26  26  SER SER M . n 
D 1 26  GLN 26  27  27  GLN GLN M . n 
D 1 27  ASN 27  27  27  ASN ASN M A n 
D 1 28  VAL 28  27  27  VAL VAL M B n 
D 1 29  TYR 29  28  28  TYR TYR M . n 
D 1 30  SER 30  29  29  SER SER M . n 
D 1 31  ASN 31  30  30  ASN ASN M . n 
D 1 32  ASN 32  31  31  ASN ASN M . n 
D 1 33  ASN 33  32  32  ASN ASN M . n 
D 1 34  LEU 34  33  33  LEU LEU M . n 
D 1 35  ALA 35  34  34  ALA ALA M . n 
D 1 36  TRP 36  35  35  TRP TRP M . n 
D 1 37  PHE 37  36  36  PHE PHE M . n 
D 1 38  GLN 38  37  37  GLN GLN M . n 
D 1 39  GLN 39  38  38  GLN GLN M . n 
D 1 40  LYS 40  39  39  LYS LYS M . n 
D 1 41  PRO 41  40  40  PRO PRO M . n 
D 1 42  GLY 42  41  41  GLY GLY M . n 
D 1 43  GLN 43  42  42  GLN GLN M . n 
D 1 44  PRO 44  43  43  PRO PRO M . n 
D 1 45  PRO 45  44  44  PRO PRO M . n 
D 1 46  ARG 46  45  45  ARG ARG M . n 
D 1 47  LEU 47  46  46  LEU LEU M . n 
D 1 48  LEU 48  47  47  LEU LEU M . n 
D 1 49  ILE 49  48  48  ILE ILE M . n 
D 1 50  TYR 50  49  49  TYR TYR M . n 
D 1 51  ASP 51  50  50  ASP ASP M . n 
D 1 52  ALA 52  51  51  ALA ALA M . n 
D 1 53  SER 53  52  52  SER SER M . n 
D 1 54  LYS 54  53  53  LYS LYS M . n 
D 1 55  LEU 55  54  54  LEU LEU M . n 
D 1 56  ALA 56  55  55  ALA ALA M . n 
D 1 57  SER 57  56  56  SER SER M . n 
D 1 58  GLY 58  57  57  GLY GLY M . n 
D 1 59  VAL 59  58  58  VAL VAL M . n 
D 1 60  PRO 60  59  59  PRO PRO M . n 
D 1 61  SER 61  60  60  SER SER M . n 
D 1 62  ARG 62  61  61  ARG ARG M . n 
D 1 63  PHE 63  62  62  PHE PHE M . n 
D 1 64  LYS 64  63  63  LYS LYS M . n 
D 1 65  GLY 65  64  64  GLY GLY M . n 
D 1 66  SER 66  65  65  SER SER M . n 
D 1 67  GLY 67  66  66  GLY GLY M . n 
D 1 68  SER 68  67  67  SER SER M . n 
D 1 69  GLY 69  68  68  GLY GLY M . n 
D 1 70  THR 70  69  69  THR THR M . n 
D 1 71  GLN 71  70  70  GLN GLN M . n 
D 1 72  PHE 72  71  71  PHE PHE M . n 
D 1 73  THR 73  72  72  THR THR M . n 
D 1 74  PHE 74  73  73  PHE PHE M . n 
D 1 75  THR 75  74  74  THR THR M . n 
D 1 76  ILE 76  75  75  ILE ILE M . n 
D 1 77  SER 77  76  76  SER SER M . n 
D 1 78  ASP 78  77  77  ASP ASP M . n 
D 1 79  VAL 79  78  78  VAL VAL M . n 
D 1 80  GLN 80  79  79  GLN GLN M . n 
D 1 81  CYS 81  80  80  CYS CYS M . n 
D 1 82  ASP 82  81  81  ASP ASP M . n 
D 1 83  ASP 83  82  82  ASP ASP M . n 
D 1 84  ALA 84  83  83  ALA ALA M . n 
D 1 85  ALA 85  84  84  ALA ALA M . n 
D 1 86  THR 86  85  85  THR THR M . n 
D 1 87  PHE 87  86  86  PHE PHE M . n 
D 1 88  TYR 88  87  87  TYR TYR M . n 
D 1 89  CYS 89  88  88  CYS CYS M . n 
D 1 90  LEU 90  89  89  LEU LEU M . n 
D 1 91  GLY 91  90  90  GLY GLY M . n 
D 1 92  GLY 92  91  91  GLY GLY M . n 
D 1 93  TYR 93  92  92  TYR TYR M . n 
D 1 94  ASP 94  93  93  ASP ASP M . n 
D 1 95  CYS 95  94  94  CYS CYS M . n 
D 1 96  SER 96  95  95  SER SER M . n 
D 1 97  SER 97  95  95  SER SER M A n 
D 1 98  GLY 98  95  95  GLY GLY M B n 
D 1 99  ASP 99  95  95  ASP ASP M C n 
D 1 100 CYS 100 95  95  CYS CYS M D n 
D 1 101 ALA 101 96  96  ALA ALA M . n 
D 1 102 ALA 102 97  97  ALA ALA M . n 
D 1 103 PHE 103 98  98  PHE PHE M . n 
D 1 104 GLY 104 99  99  GLY GLY M . n 
D 1 105 GLY 105 100 100 GLY GLY M . n 
D 1 106 GLY 106 101 101 GLY GLY M . n 
D 1 107 THR 107 102 102 THR THR M . n 
D 1 108 GLU 108 103 103 GLU GLU M . n 
D 1 109 VAL 109 104 104 VAL VAL M . n 
D 1 110 VAL 110 105 105 VAL VAL M . n 
D 1 111 VAL 111 106 106 VAL VAL M . n 
D 1 112 ARG 112 107 107 ARG ARG M . n 
D 1 113 GLY 113 108 108 GLY GLY M . n 
D 1 114 ASP 114 109 109 ASP ASP M . n 
D 1 115 PRO 115 110 110 PRO PRO M . n 
D 1 116 VAL 116 111 111 VAL VAL M . n 
D 1 117 ALA 117 112 112 ALA ALA M . n 
D 1 118 PRO 118 113 113 PRO PRO M . n 
D 1 119 THR 119 114 114 THR THR M . n 
D 1 120 VAL 120 115 115 VAL VAL M . n 
D 1 121 LEU 121 116 116 LEU LEU M . n 
D 1 122 ILE 122 117 117 ILE ILE M . n 
D 1 123 PHE 123 118 118 PHE PHE M . n 
D 1 124 PRO 124 119 119 PRO PRO M . n 
D 1 125 PRO 125 120 120 PRO PRO M . n 
D 1 126 ALA 126 121 121 ALA ALA M . n 
D 1 127 ALA 127 122 122 ALA ALA M . n 
D 1 128 ASP 128 123 123 ASP ASP M . n 
D 1 129 GLN 129 124 124 GLN GLN M . n 
D 1 130 VAL 130 125 125 VAL VAL M . n 
D 1 131 ALA 131 126 126 ALA ALA M . n 
D 1 132 THR 132 127 127 THR THR M . n 
D 1 133 GLY 133 128 128 GLY GLY M . n 
D 1 134 THR 134 129 129 THR THR M . n 
D 1 135 VAL 135 130 130 VAL VAL M . n 
D 1 136 THR 136 131 131 THR THR M . n 
D 1 137 ILE 137 132 132 ILE ILE M . n 
D 1 138 VAL 138 133 133 VAL VAL M . n 
D 1 139 CYS 139 134 134 CYS CYS M . n 
D 1 140 VAL 140 135 135 VAL VAL M . n 
D 1 141 ALA 141 136 136 ALA ALA M . n 
D 1 142 ASN 142 137 137 ASN ASN M . n 
D 1 143 LYS 143 138 138 LYS LYS M . n 
D 1 144 TYR 144 139 139 TYR TYR M . n 
D 1 145 PHE 145 140 140 PHE PHE M . n 
D 1 146 PRO 146 141 141 PRO PRO M . n 
D 1 147 ASP 147 142 142 ASP ASP M . n 
D 1 148 VAL 148 143 143 VAL VAL M . n 
D 1 149 THR 149 144 144 THR THR M . n 
D 1 150 VAL 150 145 145 VAL VAL M . n 
D 1 151 THR 151 146 146 THR THR M . n 
D 1 152 TRP 152 147 147 TRP TRP M . n 
D 1 153 GLU 153 148 148 GLU GLU M . n 
D 1 154 VAL 154 149 149 VAL VAL M . n 
D 1 155 ASP 155 150 150 ASP ASP M . n 
D 1 156 GLY 156 151 151 GLY GLY M . n 
D 1 157 THR 157 152 152 THR THR M . n 
D 1 158 THR 158 153 153 THR THR M . n 
D 1 159 GLN 159 154 154 GLN GLN M . n 
D 1 160 THR 160 155 155 THR THR M . n 
D 1 161 THR 161 156 156 THR THR M . n 
D 1 162 GLY 162 157 157 GLY GLY M . n 
D 1 163 ILE 163 158 158 ILE ILE M . n 
D 1 164 GLU 164 159 159 GLU GLU M . n 
D 1 165 ASN 165 160 160 ASN ASN M . n 
D 1 166 SER 166 161 161 SER SER M . n 
D 1 167 LYS 167 162 162 LYS LYS M . n 
D 1 168 THR 168 163 163 THR THR M . n 
D 1 169 PRO 169 164 164 PRO PRO M . n 
D 1 170 GLN 170 165 165 GLN GLN M . n 
D 1 171 ASN 171 166 166 ASN ASN M . n 
D 1 172 SER 172 167 167 SER SER M . n 
D 1 173 ALA 173 168 168 ALA ALA M . n 
D 1 174 ASP 174 169 169 ASP ASP M . n 
D 1 175 CYS 175 170 170 CYS CYS M . n 
D 1 176 THR 176 171 171 THR THR M . n 
D 1 177 TYR 177 172 172 TYR TYR M . n 
D 1 178 ASN 178 173 173 ASN ASN M . n 
D 1 179 LEU 179 174 174 LEU LEU M . n 
D 1 180 SER 180 175 175 SER SER M . n 
D 1 181 SER 181 176 176 SER SER M . n 
D 1 182 THR 182 177 177 THR THR M . n 
D 1 183 LEU 183 178 178 LEU LEU M . n 
D 1 184 THR 184 179 179 THR THR M . n 
D 1 185 LEU 185 180 180 LEU LEU M . n 
D 1 186 THR 186 181 181 THR THR M . n 
D 1 187 SER 187 182 182 SER SER M . n 
D 1 188 THR 188 183 183 THR THR M . n 
D 1 189 GLN 189 184 184 GLN GLN M . n 
D 1 190 TYR 190 185 185 TYR TYR M . n 
D 1 191 ASN 191 186 186 ASN ASN M . n 
D 1 192 SER 192 187 187 SER SER M . n 
D 1 193 HIS 193 188 188 HIS HIS M . n 
D 1 194 LYS 194 189 189 LYS LYS M . n 
D 1 195 GLU 195 190 190 GLU GLU M . n 
D 1 196 TYR 196 191 191 TYR TYR M . n 
D 1 197 THR 197 192 192 THR THR M . n 
D 1 198 CYS 198 193 193 CYS CYS M . n 
D 1 199 LYS 199 194 194 LYS LYS M . n 
D 1 200 VAL 200 195 195 VAL VAL M . n 
D 1 201 THR 201 196 196 THR THR M . n 
D 1 202 GLN 202 197 197 GLN GLN M . n 
D 1 203 GLY 203 198 198 GLY GLY M . n 
D 1 204 THR 204 199 199 THR THR M . n 
D 1 205 THR 205 200 200 THR THR M . n 
D 1 206 SER 206 201 201 SER SER M . n 
D 1 207 VAL 207 202 202 VAL VAL M . n 
D 1 208 VAL 208 203 203 VAL VAL M . n 
D 1 209 GLN 209 204 204 GLN GLN M . n 
D 1 210 SER 210 205 205 SER SER M . n 
D 1 211 PHE 211 206 206 PHE PHE M . n 
D 1 212 ASN 212 207 207 ASN ASN M . n 
D 1 213 ARG 213 208 208 ARG ARG M . n 
D 1 214 GLY 214 209 209 GLY GLY M . n 
D 1 215 ASP 215 210 210 ASP ASP M . n 
D 1 216 CYS 216 211 211 CYS CYS M . n 
E 2 1   GLN 1   2   2   GLN GLN I . n 
E 2 2   SER 2   3   3   SER SER I . n 
E 2 3   LEU 3   4   4   LEU LEU I . n 
E 2 4   GLU 4   5   5   GLU GLU I . n 
E 2 5   GLU 5   6   6   GLU GLU I . n 
E 2 6   SER 6   7   7   SER SER I . n 
E 2 7   GLY 7   8   8   GLY GLY I . n 
E 2 8   GLY 8   9   9   GLY GLY I . n 
E 2 9   ASP 9   10  10  ASP ASP I . n 
E 2 10  LEU 10  11  11  LEU LEU I . n 
E 2 11  VAL 11  12  12  VAL VAL I . n 
E 2 12  GLN 12  13  13  GLN GLN I . n 
E 2 13  PRO 13  14  14  PRO PRO I . n 
E 2 14  GLY 14  15  15  GLY GLY I . n 
E 2 15  ALA 15  16  16  ALA ALA I . n 
E 2 16  SER 16  17  17  SER SER I . n 
E 2 17  LEU 17  18  18  LEU LEU I . n 
E 2 18  THR 18  19  19  THR THR I . n 
E 2 19  LEU 19  20  20  LEU LEU I . n 
E 2 20  THR 20  21  21  THR THR I . n 
E 2 21  CYS 21  22  22  CYS CYS I . n 
E 2 22  LYS 22  23  23  LYS LYS I . n 
E 2 23  ALA 23  24  24  ALA ALA I . n 
E 2 24  SER 24  25  25  SER SER I . n 
E 2 25  GLY 25  26  26  GLY GLY I . n 
E 2 26  PHE 26  27  27  PHE PHE I . n 
E 2 27  SER 27  28  28  SER SER I . n 
E 2 28  PHE 28  29  29  PHE PHE I . n 
E 2 29  GLY 29  30  30  GLY GLY I . n 
E 2 30  ASN 30  31  31  ASN ASN I . n 
E 2 31  ASN 31  32  32  ASN ASN I . n 
E 2 32  TYR 32  33  33  TYR TYR I . n 
E 2 33  ASP 33  34  34  ASP ASP I . n 
E 2 34  MET 34  35  35  MET MET I . n 
E 2 35  CYS 35  35  35  CYS CYS I A n 
E 2 36  TRP 36  36  36  TRP TRP I . n 
E 2 37  VAL 37  37  37  VAL VAL I . n 
E 2 38  ARG 38  38  38  ARG ARG I . n 
E 2 39  GLN 39  39  39  GLN GLN I . n 
E 2 40  ALA 40  40  40  ALA ALA I . n 
E 2 41  PRO 41  41  41  PRO PRO I . n 
E 2 42  GLY 42  42  42  GLY GLY I . n 
E 2 43  LYS 43  43  43  LYS LYS I . n 
E 2 44  GLY 44  44  44  GLY GLY I . n 
E 2 45  LEU 45  45  45  LEU LEU I . n 
E 2 46  GLU 46  46  46  GLU GLU I . n 
E 2 47  TRP 47  47  47  TRP TRP I . n 
E 2 48  ILE 48  48  48  ILE ILE I . n 
E 2 49  GLY 49  49  49  GLY GLY I . n 
E 2 50  CYS 50  50  50  CYS CYS I . n 
E 2 51  ILE 51  51  51  ILE ILE I . n 
E 2 52  GLU 52  52  52  GLU GLU I . n 
E 2 53  THR 53  52  52  THR THR I A n 
E 2 54  GLY 54  52  52  GLY GLY I B n 
E 2 55  SER 55  53  53  SER SER I . n 
E 2 56  SER 56  54  54  SER SER I . n 
E 2 57  ASP 57  55  55  ASP ASP I . n 
E 2 58  SER 58  56  56  SER SER I . n 
E 2 59  ALA 59  57  57  ALA ALA I . n 
E 2 60  ALA 60  58  58  ALA ALA I . n 
E 2 61  TYR 61  59  59  TYR TYR I . n 
E 2 62  ALA 62  60  60  ALA ALA I . n 
E 2 63  THR 63  61  61  THR THR I . n 
E 2 64  TRP 64  62  62  TRP TRP I . n 
E 2 65  ALA 65  63  63  ALA ALA I . n 
E 2 66  LYS 66  64  64  LYS LYS I . n 
E 2 67  GLY 67  65  65  GLY GLY I . n 
E 2 68  ARG 68  66  66  ARG ARG I . n 
E 2 69  PHE 69  67  67  PHE PHE I . n 
E 2 70  THR 70  68  68  THR THR I . n 
E 2 71  ILE 71  69  69  ILE ILE I . n 
E 2 72  SER 72  70  70  SER SER I . n 
E 2 73  LYS 73  71  71  LYS LYS I . n 
E 2 74  THR 74  72  72  THR THR I . n 
E 2 75  SER 75  73  73  SER SER I . n 
E 2 76  SER 76  74  74  SER SER I . n 
E 2 77  THR 77  75  75  THR THR I . n 
E 2 78  THR 78  76  76  THR THR I . n 
E 2 79  VAL 79  77  77  VAL VAL I . n 
E 2 80  THR 80  78  78  THR THR I . n 
E 2 81  LEU 81  79  79  LEU LEU I . n 
E 2 82  GLN 82  80  80  GLN GLN I . n 
E 2 83  MET 83  81  81  MET MET I . n 
E 2 84  THR 84  82  82  THR THR I . n 
E 2 85  SER 85  82  82  SER SER I A n 
E 2 86  LEU 86  82  82  LEU LEU I B n 
E 2 87  THR 87  83  83  THR THR I . n 
E 2 88  ALA 88  84  84  ALA ALA I . n 
E 2 89  ALA 89  85  85  ALA ALA I . n 
E 2 90  ASP 90  86  86  ASP ASP I . n 
E 2 91  THR 91  87  87  THR THR I . n 
E 2 92  ALA 92  88  88  ALA ALA I . n 
E 2 93  THR 93  89  89  THR THR I . n 
E 2 94  TYR 94  90  90  TYR TYR I . n 
E 2 95  PHE 95  91  91  PHE PHE I . n 
E 2 96  CYS 96  92  92  CYS CYS I . n 
E 2 97  ALA 97  93  93  ALA ALA I . n 
E 2 98  ARG 98  94  94  ARG ARG I . n 
E 2 99  ASN 99  95  95  ASN ASN I . n 
E 2 100 PHE 100 96  96  PHE PHE I . n 
E 2 101 ASP 101 101 101 ASP ASP I . n 
E 2 102 LEU 102 102 102 LEU LEU I . n 
E 2 103 TRP 103 103 103 TRP TRP I . n 
E 2 104 GLY 104 104 104 GLY GLY I . n 
E 2 105 PRO 105 105 105 PRO PRO I . n 
E 2 106 GLY 106 106 106 GLY GLY I . n 
E 2 107 THR 107 107 107 THR THR I . n 
E 2 108 LEU 108 108 108 LEU LEU I . n 
E 2 109 VAL 109 109 109 VAL VAL I . n 
E 2 110 ILE 110 110 110 ILE ILE I . n 
E 2 111 VAL 111 111 111 VAL VAL I . n 
E 2 112 SER 112 112 112 SER SER I . n 
E 2 113 SER 113 113 113 SER SER I . n 
E 2 114 GLY 114 114 114 GLY GLY I . n 
E 2 115 GLN 115 115 115 GLN GLN I . n 
E 2 116 PRO 116 116 116 PRO PRO I . n 
E 2 117 LYS 117 117 117 LYS LYS I . n 
E 2 118 ALA 118 118 118 ALA ALA I . n 
E 2 119 PRO 119 119 119 PRO PRO I . n 
E 2 120 SER 120 120 120 SER SER I . n 
E 2 121 VAL 121 121 121 VAL VAL I . n 
E 2 122 PHE 122 122 122 PHE PHE I . n 
E 2 123 PRO 123 123 123 PRO PRO I . n 
E 2 124 LEU 124 124 124 LEU LEU I . n 
E 2 125 ALA 125 125 125 ALA ALA I . n 
E 2 126 PRO 126 126 126 PRO PRO I . n 
E 2 127 CYS 127 127 127 CYS CYS I . n 
E 2 128 CYS 128 128 128 CYS CYS I . n 
E 2 129 GLY 129 129 129 GLY GLY I . n 
E 2 130 ASP 130 130 130 ASP ASP I . n 
E 2 131 THR 131 131 131 THR THR I . n 
E 2 132 PRO 132 132 132 PRO PRO I . n 
E 2 133 SER 133 133 133 SER SER I . n 
E 2 134 SER 134 134 134 SER SER I . n 
E 2 135 THR 135 135 135 THR THR I . n 
E 2 136 VAL 136 136 136 VAL VAL I . n 
E 2 137 THR 137 137 137 THR THR I . n 
E 2 138 LEU 138 138 138 LEU LEU I . n 
E 2 139 GLY 139 139 139 GLY GLY I . n 
E 2 140 CYS 140 140 140 CYS CYS I . n 
E 2 141 LEU 141 141 141 LEU LEU I . n 
E 2 142 VAL 142 142 142 VAL VAL I . n 
E 2 143 LYS 143 143 143 LYS LYS I . n 
E 2 144 GLY 144 144 144 GLY GLY I . n 
E 2 145 TYR 145 145 145 TYR TYR I . n 
E 2 146 LEU 146 146 146 LEU LEU I . n 
E 2 147 PRO 147 147 147 PRO PRO I . n 
E 2 148 GLU 148 148 148 GLU GLU I . n 
E 2 149 PRO 149 149 149 PRO PRO I . n 
E 2 150 VAL 150 150 150 VAL VAL I . n 
E 2 151 THR 151 151 151 THR THR I . n 
E 2 152 VAL 152 152 152 VAL VAL I . n 
E 2 153 THR 153 153 153 THR THR I . n 
E 2 154 TRP 154 154 154 TRP TRP I . n 
E 2 155 ASN 155 155 155 ASN ASN I . n 
E 2 156 SER 156 156 156 SER SER I . n 
E 2 157 GLY 157 157 157 GLY GLY I . n 
E 2 158 THR 158 158 158 THR THR I . n 
E 2 159 LEU 159 159 159 LEU LEU I . n 
E 2 160 THR 160 160 160 THR THR I . n 
E 2 161 ASN 161 161 161 ASN ASN I . n 
E 2 162 GLY 162 162 162 GLY GLY I . n 
E 2 163 VAL 163 163 163 VAL VAL I . n 
E 2 164 ARG 164 164 164 ARG ARG I . n 
E 2 165 THR 165 165 165 THR THR I . n 
E 2 166 PHE 166 166 166 PHE PHE I . n 
E 2 167 PRO 167 167 167 PRO PRO I . n 
E 2 168 SER 168 168 168 SER SER I . n 
E 2 169 VAL 169 169 169 VAL VAL I . n 
E 2 170 ARG 170 170 170 ARG ARG I . n 
E 2 171 GLN 171 171 171 GLN GLN I . n 
E 2 172 SER 172 172 172 SER SER I . n 
E 2 173 SER 173 173 173 SER SER I . n 
E 2 174 GLY 174 174 174 GLY GLY I . n 
E 2 175 LEU 175 175 175 LEU LEU I . n 
E 2 176 TYR 176 176 176 TYR TYR I . n 
E 2 177 SER 177 177 177 SER SER I . n 
E 2 178 LEU 178 178 178 LEU LEU I . n 
E 2 179 SER 179 179 179 SER SER I . n 
E 2 180 SER 180 180 180 SER SER I . n 
E 2 181 VAL 181 181 181 VAL VAL I . n 
E 2 182 VAL 182 182 182 VAL VAL I . n 
E 2 183 SER 183 183 183 SER SER I . n 
E 2 184 VAL 184 184 184 VAL VAL I . n 
E 2 185 THR 185 185 185 THR THR I . n 
E 2 186 SER 186 186 186 SER SER I . n 
E 2 187 SER 187 187 187 SER SER I . n 
E 2 188 SER 188 188 188 SER SER I . n 
E 2 189 GLN 189 189 189 GLN GLN I . n 
E 2 190 PRO 190 190 190 PRO PRO I . n 
E 2 191 VAL 191 191 191 VAL VAL I . n 
E 2 192 THR 192 192 192 THR THR I . n 
E 2 193 CYS 193 193 193 CYS CYS I . n 
E 2 194 ASN 194 194 194 ASN ASN I . n 
E 2 195 VAL 195 195 195 VAL VAL I . n 
E 2 196 ALA 196 196 196 ALA ALA I . n 
E 2 197 HIS 197 197 197 HIS HIS I . n 
E 2 198 PRO 198 198 198 PRO PRO I . n 
E 2 199 ALA 199 199 199 ALA ALA I . n 
E 2 200 THR 200 200 200 THR THR I . n 
E 2 201 ASN 201 201 201 ASN ASN I . n 
E 2 202 THR 202 202 202 THR THR I . n 
E 2 203 LYS 203 203 203 LYS LYS I . n 
E 2 204 VAL 204 204 204 VAL VAL I . n 
E 2 205 ASP 205 205 205 ASP ASP I . n 
E 2 206 LYS 206 206 206 LYS LYS I . n 
E 2 207 THR 207 207 207 THR THR I . n 
E 2 208 VAL 208 208 208 VAL VAL I . n 
E 2 209 ALA 209 209 209 ALA ALA I . n 
E 2 210 PRO 210 210 210 PRO PRO I . n 
E 2 211 SER 211 211 211 SER SER I . n 
E 2 212 THR 212 212 212 THR THR I . n 
E 2 213 CYS 213 213 213 CYS CYS I . n 
F 3 1   ASN 1   301 ?   ?   ?   Q . n 
F 3 2   ASN 2   302 ?   ?   ?   Q . n 
F 3 3   THR 3   303 303 THR THR Q . n 
F 3 4   ARG 4   304 304 ARG ARG Q . n 
F 3 5   LYS 5   305 305 LYS LYS Q . n 
F 3 6   SER 6   306 306 SER SER Q . n 
F 3 7   ILE 7   307 307 ILE ILE Q . n 
F 3 8   HIS 8   308 308 HIS HIS Q . n 
F 3 9   ILE 9   309 309 ILE ILE Q . n 
F 3 10  GLY 10  312 312 GLY GLY Q . n 
F 3 11  PRO 11  313 313 PRO PRO Q . n 
F 3 12  GLY 12  314 314 GLY GLY Q . n 
F 3 13  ARG 13  315 ?   ?   ?   Q . n 
F 3 14  ALA 14  316 ?   ?   ?   Q . n 
F 3 15  PHE 15  317 ?   ?   ?   Q . n 
F 3 16  TYR 16  318 ?   ?   ?   Q . n 
F 3 17  THR 17  319 ?   ?   ?   Q . n 
F 3 18  THR 18  320 ?   ?   ?   Q . n 
F 3 19  GLY 19  321 ?   ?   ?   Q . n 
F 3 20  GLU 20  322 ?   ?   ?   Q . n 
F 3 21  ILE 21  323 ?   ?   ?   Q . n 
F 3 22  ILE 22  324 ?   ?   ?   Q . n 
F 3 23  GLY 23  325 ?   ?   ?   Q . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
G 4 CA  1   301 1   CA  CA  L . 
H 4 CA  1   302 5   CA  CA  L . 
I 4 CA  1   301 4   CA  CA  H . 
J 4 CA  1   301 2   CA  CA  M . 
K 4 CA  1   301 3   CA  CA  I . 
L 5 HOH 1   401 3   HOH HOH L . 
L 5 HOH 2   402 13  HOH HOH L . 
L 5 HOH 3   403 16  HOH HOH L . 
L 5 HOH 4   404 17  HOH HOH L . 
L 5 HOH 5   405 19  HOH HOH L . 
L 5 HOH 6   406 31  HOH HOH L . 
L 5 HOH 7   407 35  HOH HOH L . 
L 5 HOH 8   408 38  HOH HOH L . 
L 5 HOH 9   409 41  HOH HOH L . 
L 5 HOH 10  410 47  HOH HOH L . 
L 5 HOH 11  411 59  HOH HOH L . 
L 5 HOH 12  412 60  HOH HOH L . 
L 5 HOH 13  413 61  HOH HOH L . 
L 5 HOH 14  414 63  HOH HOH L . 
L 5 HOH 15  415 66  HOH HOH L . 
L 5 HOH 16  416 69  HOH HOH L . 
L 5 HOH 17  417 70  HOH HOH L . 
L 5 HOH 18  418 71  HOH HOH L . 
L 5 HOH 19  419 73  HOH HOH L . 
L 5 HOH 20  420 75  HOH HOH L . 
L 5 HOH 21  421 77  HOH HOH L . 
L 5 HOH 22  422 78  HOH HOH L . 
L 5 HOH 23  423 80  HOH HOH L . 
L 5 HOH 24  424 87  HOH HOH L . 
L 5 HOH 25  425 89  HOH HOH L . 
L 5 HOH 26  426 91  HOH HOH L . 
L 5 HOH 27  427 92  HOH HOH L . 
L 5 HOH 28  428 93  HOH HOH L . 
L 5 HOH 29  429 97  HOH HOH L . 
L 5 HOH 30  430 101 HOH HOH L . 
L 5 HOH 31  431 102 HOH HOH L . 
L 5 HOH 32  432 105 HOH HOH L . 
L 5 HOH 33  433 107 HOH HOH L . 
L 5 HOH 34  434 114 HOH HOH L . 
L 5 HOH 35  435 117 HOH HOH L . 
L 5 HOH 36  436 131 HOH HOH L . 
L 5 HOH 37  437 142 HOH HOH L . 
L 5 HOH 38  438 150 HOH HOH L . 
L 5 HOH 39  439 151 HOH HOH L . 
L 5 HOH 40  440 160 HOH HOH L . 
L 5 HOH 41  441 163 HOH HOH L . 
L 5 HOH 42  442 164 HOH HOH L . 
L 5 HOH 43  443 167 HOH HOH L . 
L 5 HOH 44  444 170 HOH HOH L . 
L 5 HOH 45  445 171 HOH HOH L . 
L 5 HOH 46  446 177 HOH HOH L . 
L 5 HOH 47  447 178 HOH HOH L . 
L 5 HOH 48  448 182 HOH HOH L . 
L 5 HOH 49  449 184 HOH HOH L . 
L 5 HOH 50  450 192 HOH HOH L . 
L 5 HOH 51  451 193 HOH HOH L . 
L 5 HOH 52  452 201 HOH HOH L . 
L 5 HOH 53  453 205 HOH HOH L . 
L 5 HOH 54  454 210 HOH HOH L . 
L 5 HOH 55  455 212 HOH HOH L . 
L 5 HOH 56  456 216 HOH HOH L . 
L 5 HOH 57  457 222 HOH HOH L . 
L 5 HOH 58  458 223 HOH HOH L . 
L 5 HOH 59  459 230 HOH HOH L . 
L 5 HOH 60  460 231 HOH HOH L . 
L 5 HOH 61  461 238 HOH HOH L . 
L 5 HOH 62  462 243 HOH HOH L . 
L 5 HOH 63  463 247 HOH HOH L . 
L 5 HOH 64  464 248 HOH HOH L . 
L 5 HOH 65  465 250 HOH HOH L . 
L 5 HOH 66  466 251 HOH HOH L . 
L 5 HOH 67  467 254 HOH HOH L . 
L 5 HOH 68  468 257 HOH HOH L . 
L 5 HOH 69  469 261 HOH HOH L . 
L 5 HOH 70  470 263 HOH HOH L . 
L 5 HOH 71  471 279 HOH HOH L . 
L 5 HOH 72  472 280 HOH HOH L . 
L 5 HOH 73  473 287 HOH HOH L . 
L 5 HOH 74  474 288 HOH HOH L . 
L 5 HOH 75  475 297 HOH HOH L . 
L 5 HOH 76  476 298 HOH HOH L . 
L 5 HOH 77  477 303 HOH HOH L . 
L 5 HOH 78  478 307 HOH HOH L . 
L 5 HOH 79  479 313 HOH HOH L . 
L 5 HOH 80  480 315 HOH HOH L . 
L 5 HOH 81  481 318 HOH HOH L . 
L 5 HOH 82  482 321 HOH HOH L . 
L 5 HOH 83  483 324 HOH HOH L . 
L 5 HOH 84  484 325 HOH HOH L . 
L 5 HOH 85  485 326 HOH HOH L . 
L 5 HOH 86  486 328 HOH HOH L . 
L 5 HOH 87  487 329 HOH HOH L . 
L 5 HOH 88  488 330 HOH HOH L . 
L 5 HOH 89  489 334 HOH HOH L . 
L 5 HOH 90  490 353 HOH HOH L . 
L 5 HOH 91  491 364 HOH HOH L . 
L 5 HOH 92  492 365 HOH HOH L . 
L 5 HOH 93  493 366 HOH HOH L . 
L 5 HOH 94  494 372 HOH HOH L . 
L 5 HOH 95  495 374 HOH HOH L . 
L 5 HOH 96  496 380 HOH HOH L . 
L 5 HOH 97  497 381 HOH HOH L . 
L 5 HOH 98  498 384 HOH HOH L . 
L 5 HOH 99  499 385 HOH HOH L . 
L 5 HOH 100 500 387 HOH HOH L . 
L 5 HOH 101 501 389 HOH HOH L . 
L 5 HOH 102 502 390 HOH HOH L . 
L 5 HOH 103 503 395 HOH HOH L . 
L 5 HOH 104 504 396 HOH HOH L . 
L 5 HOH 105 505 397 HOH HOH L . 
L 5 HOH 106 506 400 HOH HOH L . 
L 5 HOH 107 507 403 HOH HOH L . 
L 5 HOH 108 508 413 HOH HOH L . 
L 5 HOH 109 509 416 HOH HOH L . 
L 5 HOH 110 510 421 HOH HOH L . 
L 5 HOH 111 511 426 HOH HOH L . 
L 5 HOH 112 512 433 HOH HOH L . 
L 5 HOH 113 513 438 HOH HOH L . 
L 5 HOH 114 514 457 HOH HOH L . 
L 5 HOH 115 515 462 HOH HOH L . 
L 5 HOH 116 516 466 HOH HOH L . 
L 5 HOH 117 517 476 HOH HOH L . 
L 5 HOH 118 518 480 HOH HOH L . 
L 5 HOH 119 519 481 HOH HOH L . 
L 5 HOH 120 520 486 HOH HOH L . 
L 5 HOH 121 521 495 HOH HOH L . 
L 5 HOH 122 522 500 HOH HOH L . 
L 5 HOH 123 523 502 HOH HOH L . 
L 5 HOH 124 524 519 HOH HOH L . 
L 5 HOH 125 525 522 HOH HOH L . 
L 5 HOH 126 526 526 HOH HOH L . 
L 5 HOH 127 527 535 HOH HOH L . 
L 5 HOH 128 528 552 HOH HOH L . 
L 5 HOH 129 529 554 HOH HOH L . 
L 5 HOH 130 530 558 HOH HOH L . 
L 5 HOH 131 531 559 HOH HOH L . 
L 5 HOH 132 532 561 HOH HOH L . 
L 5 HOH 133 533 562 HOH HOH L . 
L 5 HOH 134 534 571 HOH HOH L . 
L 5 HOH 135 535 573 HOH HOH L . 
L 5 HOH 136 536 584 HOH HOH L . 
L 5 HOH 137 537 585 HOH HOH L . 
L 5 HOH 138 538 587 HOH HOH L . 
L 5 HOH 139 539 590 HOH HOH L . 
L 5 HOH 140 540 591 HOH HOH L . 
L 5 HOH 141 541 594 HOH HOH L . 
L 5 HOH 142 542 600 HOH HOH L . 
L 5 HOH 143 543 601 HOH HOH L . 
L 5 HOH 144 544 604 HOH HOH L . 
L 5 HOH 145 545 609 HOH HOH L . 
L 5 HOH 146 546 612 HOH HOH L . 
L 5 HOH 147 547 613 HOH HOH L . 
L 5 HOH 148 548 614 HOH HOH L . 
L 5 HOH 149 549 620 HOH HOH L . 
L 5 HOH 150 550 623 HOH HOH L . 
L 5 HOH 151 551 627 HOH HOH L . 
L 5 HOH 152 552 629 HOH HOH L . 
L 5 HOH 153 553 630 HOH HOH L . 
L 5 HOH 154 554 639 HOH HOH L . 
L 5 HOH 155 555 644 HOH HOH L . 
L 5 HOH 156 556 645 HOH HOH L . 
L 5 HOH 157 557 648 HOH HOH L . 
L 5 HOH 158 558 651 HOH HOH L . 
L 5 HOH 159 559 652 HOH HOH L . 
L 5 HOH 160 560 653 HOH HOH L . 
L 5 HOH 161 561 655 HOH HOH L . 
L 5 HOH 162 562 656 HOH HOH L . 
L 5 HOH 163 563 658 HOH HOH L . 
L 5 HOH 164 564 660 HOH HOH L . 
L 5 HOH 165 565 661 HOH HOH L . 
L 5 HOH 166 566 670 HOH HOH L . 
L 5 HOH 167 567 678 HOH HOH L . 
L 5 HOH 168 568 682 HOH HOH L . 
L 5 HOH 169 569 684 HOH HOH L . 
L 5 HOH 170 570 687 HOH HOH L . 
L 5 HOH 171 571 693 HOH HOH L . 
L 5 HOH 172 572 703 HOH HOH L . 
L 5 HOH 173 573 714 HOH HOH L . 
L 5 HOH 174 574 717 HOH HOH L . 
L 5 HOH 175 575 735 HOH HOH L . 
L 5 HOH 176 576 742 HOH HOH L . 
L 5 HOH 177 577 743 HOH HOH L . 
L 5 HOH 178 578 751 HOH HOH L . 
L 5 HOH 179 579 752 HOH HOH L . 
L 5 HOH 180 580 757 HOH HOH L . 
L 5 HOH 181 581 759 HOH HOH L . 
L 5 HOH 182 582 761 HOH HOH L . 
L 5 HOH 183 583 766 HOH HOH L . 
L 5 HOH 184 584 768 HOH HOH L . 
L 5 HOH 185 585 769 HOH HOH L . 
L 5 HOH 186 586 772 HOH HOH L . 
L 5 HOH 187 587 773 HOH HOH L . 
L 5 HOH 188 588 775 HOH HOH L . 
L 5 HOH 189 589 777 HOH HOH L . 
L 5 HOH 190 590 780 HOH HOH L . 
L 5 HOH 191 591 784 HOH HOH L . 
L 5 HOH 192 592 790 HOH HOH L . 
L 5 HOH 193 593 793 HOH HOH L . 
L 5 HOH 194 594 794 HOH HOH L . 
L 5 HOH 195 595 796 HOH HOH L . 
L 5 HOH 196 596 798 HOH HOH L . 
L 5 HOH 197 597 800 HOH HOH L . 
L 5 HOH 198 598 804 HOH HOH L . 
M 5 HOH 1   401 538 HOH HOH H . 
M 5 HOH 2   402 4   HOH HOH H . 
M 5 HOH 3   403 6   HOH HOH H . 
M 5 HOH 4   404 9   HOH HOH H . 
M 5 HOH 5   405 22  HOH HOH H . 
M 5 HOH 6   406 26  HOH HOH H . 
M 5 HOH 7   407 28  HOH HOH H . 
M 5 HOH 8   408 34  HOH HOH H . 
M 5 HOH 9   409 37  HOH HOH H . 
M 5 HOH 10  410 42  HOH HOH H . 
M 5 HOH 11  411 48  HOH HOH H . 
M 5 HOH 12  412 54  HOH HOH H . 
M 5 HOH 13  413 64  HOH HOH H . 
M 5 HOH 14  414 65  HOH HOH H . 
M 5 HOH 15  415 79  HOH HOH H . 
M 5 HOH 16  416 85  HOH HOH H . 
M 5 HOH 17  417 98  HOH HOH H . 
M 5 HOH 18  418 106 HOH HOH H . 
M 5 HOH 19  419 108 HOH HOH H . 
M 5 HOH 20  420 110 HOH HOH H . 
M 5 HOH 21  421 121 HOH HOH H . 
M 5 HOH 22  422 123 HOH HOH H . 
M 5 HOH 23  423 125 HOH HOH H . 
M 5 HOH 24  424 128 HOH HOH H . 
M 5 HOH 25  425 133 HOH HOH H . 
M 5 HOH 26  426 135 HOH HOH H . 
M 5 HOH 27  427 136 HOH HOH H . 
M 5 HOH 28  428 137 HOH HOH H . 
M 5 HOH 29  429 138 HOH HOH H . 
M 5 HOH 30  430 140 HOH HOH H . 
M 5 HOH 31  431 143 HOH HOH H . 
M 5 HOH 32  432 144 HOH HOH H . 
M 5 HOH 33  433 149 HOH HOH H . 
M 5 HOH 34  434 154 HOH HOH H . 
M 5 HOH 35  435 155 HOH HOH H . 
M 5 HOH 36  436 158 HOH HOH H . 
M 5 HOH 37  437 161 HOH HOH H . 
M 5 HOH 38  438 168 HOH HOH H . 
M 5 HOH 39  439 173 HOH HOH H . 
M 5 HOH 40  440 174 HOH HOH H . 
M 5 HOH 41  441 176 HOH HOH H . 
M 5 HOH 42  442 179 HOH HOH H . 
M 5 HOH 43  443 183 HOH HOH H . 
M 5 HOH 44  444 196 HOH HOH H . 
M 5 HOH 45  445 199 HOH HOH H . 
M 5 HOH 46  446 200 HOH HOH H . 
M 5 HOH 47  447 202 HOH HOH H . 
M 5 HOH 48  448 204 HOH HOH H . 
M 5 HOH 49  449 213 HOH HOH H . 
M 5 HOH 50  450 217 HOH HOH H . 
M 5 HOH 51  451 220 HOH HOH H . 
M 5 HOH 52  452 224 HOH HOH H . 
M 5 HOH 53  453 227 HOH HOH H . 
M 5 HOH 54  454 228 HOH HOH H . 
M 5 HOH 55  455 229 HOH HOH H . 
M 5 HOH 56  456 232 HOH HOH H . 
M 5 HOH 57  457 236 HOH HOH H . 
M 5 HOH 58  458 239 HOH HOH H . 
M 5 HOH 59  459 241 HOH HOH H . 
M 5 HOH 60  460 244 HOH HOH H . 
M 5 HOH 61  461 255 HOH HOH H . 
M 5 HOH 62  462 256 HOH HOH H . 
M 5 HOH 63  463 262 HOH HOH H . 
M 5 HOH 64  464 266 HOH HOH H . 
M 5 HOH 65  465 270 HOH HOH H . 
M 5 HOH 66  466 273 HOH HOH H . 
M 5 HOH 67  467 282 HOH HOH H . 
M 5 HOH 68  468 286 HOH HOH H . 
M 5 HOH 69  469 294 HOH HOH H . 
M 5 HOH 70  470 299 HOH HOH H . 
M 5 HOH 71  471 304 HOH HOH H . 
M 5 HOH 72  472 305 HOH HOH H . 
M 5 HOH 73  473 306 HOH HOH H . 
M 5 HOH 74  474 312 HOH HOH H . 
M 5 HOH 75  475 316 HOH HOH H . 
M 5 HOH 76  476 322 HOH HOH H . 
M 5 HOH 77  477 327 HOH HOH H . 
M 5 HOH 78  478 332 HOH HOH H . 
M 5 HOH 79  479 335 HOH HOH H . 
M 5 HOH 80  480 337 HOH HOH H . 
M 5 HOH 81  481 347 HOH HOH H . 
M 5 HOH 82  482 354 HOH HOH H . 
M 5 HOH 83  483 356 HOH HOH H . 
M 5 HOH 84  484 358 HOH HOH H . 
M 5 HOH 85  485 359 HOH HOH H . 
M 5 HOH 86  486 362 HOH HOH H . 
M 5 HOH 87  487 371 HOH HOH H . 
M 5 HOH 88  488 373 HOH HOH H . 
M 5 HOH 89  489 375 HOH HOH H . 
M 5 HOH 90  490 377 HOH HOH H . 
M 5 HOH 91  491 386 HOH HOH H . 
M 5 HOH 92  492 392 HOH HOH H . 
M 5 HOH 93  493 393 HOH HOH H . 
M 5 HOH 94  494 399 HOH HOH H . 
M 5 HOH 95  495 406 HOH HOH H . 
M 5 HOH 96  496 410 HOH HOH H . 
M 5 HOH 97  497 412 HOH HOH H . 
M 5 HOH 98  498 417 HOH HOH H . 
M 5 HOH 99  499 422 HOH HOH H . 
M 5 HOH 100 500 423 HOH HOH H . 
M 5 HOH 101 501 424 HOH HOH H . 
M 5 HOH 102 502 428 HOH HOH H . 
M 5 HOH 103 503 434 HOH HOH H . 
M 5 HOH 104 504 437 HOH HOH H . 
M 5 HOH 105 505 447 HOH HOH H . 
M 5 HOH 106 506 450 HOH HOH H . 
M 5 HOH 107 507 452 HOH HOH H . 
M 5 HOH 108 508 454 HOH HOH H . 
M 5 HOH 109 509 463 HOH HOH H . 
M 5 HOH 110 510 469 HOH HOH H . 
M 5 HOH 111 511 471 HOH HOH H . 
M 5 HOH 112 512 472 HOH HOH H . 
M 5 HOH 113 513 475 HOH HOH H . 
M 5 HOH 114 514 477 HOH HOH H . 
M 5 HOH 115 515 479 HOH HOH H . 
M 5 HOH 116 516 489 HOH HOH H . 
M 5 HOH 117 517 490 HOH HOH H . 
M 5 HOH 118 518 492 HOH HOH H . 
M 5 HOH 119 519 496 HOH HOH H . 
M 5 HOH 120 520 505 HOH HOH H . 
M 5 HOH 121 521 507 HOH HOH H . 
M 5 HOH 122 522 508 HOH HOH H . 
M 5 HOH 123 523 511 HOH HOH H . 
M 5 HOH 124 524 513 HOH HOH H . 
M 5 HOH 125 525 516 HOH HOH H . 
M 5 HOH 126 526 517 HOH HOH H . 
M 5 HOH 127 527 523 HOH HOH H . 
M 5 HOH 128 528 524 HOH HOH H . 
M 5 HOH 129 529 525 HOH HOH H . 
M 5 HOH 130 530 533 HOH HOH H . 
M 5 HOH 131 531 534 HOH HOH H . 
M 5 HOH 132 532 537 HOH HOH H . 
M 5 HOH 133 533 541 HOH HOH H . 
M 5 HOH 134 534 542 HOH HOH H . 
M 5 HOH 135 535 543 HOH HOH H . 
M 5 HOH 136 536 551 HOH HOH H . 
M 5 HOH 137 537 560 HOH HOH H . 
M 5 HOH 138 538 565 HOH HOH H . 
M 5 HOH 139 539 566 HOH HOH H . 
M 5 HOH 140 540 568 HOH HOH H . 
M 5 HOH 141 541 570 HOH HOH H . 
M 5 HOH 142 542 575 HOH HOH H . 
M 5 HOH 143 543 576 HOH HOH H . 
M 5 HOH 144 544 592 HOH HOH H . 
M 5 HOH 145 545 595 HOH HOH H . 
M 5 HOH 146 546 596 HOH HOH H . 
M 5 HOH 147 547 597 HOH HOH H . 
M 5 HOH 148 548 608 HOH HOH H . 
M 5 HOH 149 549 618 HOH HOH H . 
M 5 HOH 150 550 621 HOH HOH H . 
M 5 HOH 151 551 622 HOH HOH H . 
M 5 HOH 152 552 624 HOH HOH H . 
M 5 HOH 153 553 625 HOH HOH H . 
M 5 HOH 154 554 633 HOH HOH H . 
M 5 HOH 155 555 637 HOH HOH H . 
M 5 HOH 156 556 641 HOH HOH H . 
M 5 HOH 157 557 647 HOH HOH H . 
M 5 HOH 158 558 654 HOH HOH H . 
M 5 HOH 159 559 657 HOH HOH H . 
M 5 HOH 160 560 659 HOH HOH H . 
M 5 HOH 161 561 662 HOH HOH H . 
M 5 HOH 162 562 663 HOH HOH H . 
M 5 HOH 163 563 666 HOH HOH H . 
M 5 HOH 164 564 667 HOH HOH H . 
M 5 HOH 165 565 675 HOH HOH H . 
M 5 HOH 166 566 677 HOH HOH H . 
M 5 HOH 167 567 679 HOH HOH H . 
M 5 HOH 168 568 695 HOH HOH H . 
M 5 HOH 169 569 696 HOH HOH H . 
M 5 HOH 170 570 699 HOH HOH H . 
M 5 HOH 171 571 701 HOH HOH H . 
M 5 HOH 172 572 705 HOH HOH H . 
M 5 HOH 173 573 707 HOH HOH H . 
M 5 HOH 174 574 709 HOH HOH H . 
M 5 HOH 175 575 711 HOH HOH H . 
M 5 HOH 176 576 715 HOH HOH H . 
M 5 HOH 177 577 723 HOH HOH H . 
M 5 HOH 178 578 725 HOH HOH H . 
M 5 HOH 179 579 727 HOH HOH H . 
M 5 HOH 180 580 734 HOH HOH H . 
M 5 HOH 181 581 737 HOH HOH H . 
M 5 HOH 182 582 738 HOH HOH H . 
M 5 HOH 183 583 739 HOH HOH H . 
M 5 HOH 184 584 741 HOH HOH H . 
M 5 HOH 185 585 747 HOH HOH H . 
M 5 HOH 186 586 754 HOH HOH H . 
M 5 HOH 187 587 756 HOH HOH H . 
M 5 HOH 188 588 763 HOH HOH H . 
M 5 HOH 189 589 767 HOH HOH H . 
M 5 HOH 190 590 771 HOH HOH H . 
M 5 HOH 191 591 782 HOH HOH H . 
M 5 HOH 192 592 788 HOH HOH H . 
M 5 HOH 193 593 797 HOH HOH H . 
M 5 HOH 194 594 799 HOH HOH H . 
M 5 HOH 195 595 803 HOH HOH H . 
N 5 HOH 1   401 44  HOH HOH P . 
N 5 HOH 2   402 269 HOH HOH P . 
N 5 HOH 3   403 339 HOH HOH P . 
N 5 HOH 4   404 382 HOH HOH P . 
N 5 HOH 5   405 540 HOH HOH P . 
N 5 HOH 6   406 744 HOH HOH P . 
O 5 HOH 1   401 8   HOH HOH M . 
O 5 HOH 2   402 10  HOH HOH M . 
O 5 HOH 3   403 12  HOH HOH M . 
O 5 HOH 4   404 14  HOH HOH M . 
O 5 HOH 5   405 18  HOH HOH M . 
O 5 HOH 6   406 21  HOH HOH M . 
O 5 HOH 7   407 23  HOH HOH M . 
O 5 HOH 8   408 24  HOH HOH M . 
O 5 HOH 9   409 32  HOH HOH M . 
O 5 HOH 10  410 36  HOH HOH M . 
O 5 HOH 11  411 39  HOH HOH M . 
O 5 HOH 12  412 40  HOH HOH M . 
O 5 HOH 13  413 45  HOH HOH M . 
O 5 HOH 14  414 46  HOH HOH M . 
O 5 HOH 15  415 49  HOH HOH M . 
O 5 HOH 16  416 50  HOH HOH M . 
O 5 HOH 17  417 51  HOH HOH M . 
O 5 HOH 18  418 52  HOH HOH M . 
O 5 HOH 19  419 55  HOH HOH M . 
O 5 HOH 20  420 56  HOH HOH M . 
O 5 HOH 21  421 57  HOH HOH M . 
O 5 HOH 22  422 58  HOH HOH M . 
O 5 HOH 23  423 62  HOH HOH M . 
O 5 HOH 24  424 68  HOH HOH M . 
O 5 HOH 25  425 74  HOH HOH M . 
O 5 HOH 26  426 76  HOH HOH M . 
O 5 HOH 27  427 82  HOH HOH M . 
O 5 HOH 28  428 84  HOH HOH M . 
O 5 HOH 29  429 86  HOH HOH M . 
O 5 HOH 30  430 90  HOH HOH M . 
O 5 HOH 31  431 95  HOH HOH M . 
O 5 HOH 32  432 99  HOH HOH M . 
O 5 HOH 33  433 103 HOH HOH M . 
O 5 HOH 34  434 104 HOH HOH M . 
O 5 HOH 35  435 112 HOH HOH M . 
O 5 HOH 36  436 113 HOH HOH M . 
O 5 HOH 37  437 118 HOH HOH M . 
O 5 HOH 38  438 120 HOH HOH M . 
O 5 HOH 39  439 124 HOH HOH M . 
O 5 HOH 40  440 126 HOH HOH M . 
O 5 HOH 41  441 127 HOH HOH M . 
O 5 HOH 42  442 129 HOH HOH M . 
O 5 HOH 43  443 134 HOH HOH M . 
O 5 HOH 44  444 148 HOH HOH M . 
O 5 HOH 45  445 152 HOH HOH M . 
O 5 HOH 46  446 156 HOH HOH M . 
O 5 HOH 47  447 162 HOH HOH M . 
O 5 HOH 48  448 165 HOH HOH M . 
O 5 HOH 49  449 166 HOH HOH M . 
O 5 HOH 50  450 169 HOH HOH M . 
O 5 HOH 51  451 172 HOH HOH M . 
O 5 HOH 52  452 175 HOH HOH M . 
O 5 HOH 53  453 185 HOH HOH M . 
O 5 HOH 54  454 186 HOH HOH M . 
O 5 HOH 55  455 187 HOH HOH M . 
O 5 HOH 56  456 191 HOH HOH M . 
O 5 HOH 57  457 194 HOH HOH M . 
O 5 HOH 58  458 206 HOH HOH M . 
O 5 HOH 59  459 207 HOH HOH M . 
O 5 HOH 60  460 211 HOH HOH M . 
O 5 HOH 61  461 214 HOH HOH M . 
O 5 HOH 62  462 218 HOH HOH M . 
O 5 HOH 63  463 219 HOH HOH M . 
O 5 HOH 64  464 221 HOH HOH M . 
O 5 HOH 65  465 225 HOH HOH M . 
O 5 HOH 66  466 233 HOH HOH M . 
O 5 HOH 67  467 234 HOH HOH M . 
O 5 HOH 68  468 240 HOH HOH M . 
O 5 HOH 69  469 246 HOH HOH M . 
O 5 HOH 70  470 249 HOH HOH M . 
O 5 HOH 71  471 252 HOH HOH M . 
O 5 HOH 72  472 258 HOH HOH M . 
O 5 HOH 73  473 260 HOH HOH M . 
O 5 HOH 74  474 267 HOH HOH M . 
O 5 HOH 75  475 268 HOH HOH M . 
O 5 HOH 76  476 271 HOH HOH M . 
O 5 HOH 77  477 272 HOH HOH M . 
O 5 HOH 78  478 275 HOH HOH M . 
O 5 HOH 79  479 276 HOH HOH M . 
O 5 HOH 80  480 277 HOH HOH M . 
O 5 HOH 81  481 281 HOH HOH M . 
O 5 HOH 82  482 292 HOH HOH M . 
O 5 HOH 83  483 300 HOH HOH M . 
O 5 HOH 84  484 301 HOH HOH M . 
O 5 HOH 85  485 302 HOH HOH M . 
O 5 HOH 86  486 311 HOH HOH M . 
O 5 HOH 87  487 314 HOH HOH M . 
O 5 HOH 88  488 319 HOH HOH M . 
O 5 HOH 89  489 333 HOH HOH M . 
O 5 HOH 90  490 336 HOH HOH M . 
O 5 HOH 91  491 341 HOH HOH M . 
O 5 HOH 92  492 345 HOH HOH M . 
O 5 HOH 93  493 346 HOH HOH M . 
O 5 HOH 94  494 348 HOH HOH M . 
O 5 HOH 95  495 350 HOH HOH M . 
O 5 HOH 96  496 351 HOH HOH M . 
O 5 HOH 97  497 352 HOH HOH M . 
O 5 HOH 98  498 360 HOH HOH M . 
O 5 HOH 99  499 378 HOH HOH M . 
O 5 HOH 100 500 388 HOH HOH M . 
O 5 HOH 101 501 398 HOH HOH M . 
O 5 HOH 102 502 402 HOH HOH M . 
O 5 HOH 103 503 404 HOH HOH M . 
O 5 HOH 104 504 405 HOH HOH M . 
O 5 HOH 105 505 408 HOH HOH M . 
O 5 HOH 106 506 409 HOH HOH M . 
O 5 HOH 107 507 415 HOH HOH M . 
O 5 HOH 108 508 420 HOH HOH M . 
O 5 HOH 109 509 431 HOH HOH M . 
O 5 HOH 110 510 442 HOH HOH M . 
O 5 HOH 111 511 443 HOH HOH M . 
O 5 HOH 112 512 444 HOH HOH M . 
O 5 HOH 113 513 446 HOH HOH M . 
O 5 HOH 114 514 455 HOH HOH M . 
O 5 HOH 115 515 456 HOH HOH M . 
O 5 HOH 116 516 467 HOH HOH M . 
O 5 HOH 117 517 468 HOH HOH M . 
O 5 HOH 118 518 473 HOH HOH M . 
O 5 HOH 119 519 478 HOH HOH M . 
O 5 HOH 120 520 482 HOH HOH M . 
O 5 HOH 121 521 483 HOH HOH M . 
O 5 HOH 122 522 485 HOH HOH M . 
O 5 HOH 123 523 491 HOH HOH M . 
O 5 HOH 124 524 497 HOH HOH M . 
O 5 HOH 125 525 498 HOH HOH M . 
O 5 HOH 126 526 501 HOH HOH M . 
O 5 HOH 127 527 503 HOH HOH M . 
O 5 HOH 128 528 504 HOH HOH M . 
O 5 HOH 129 529 509 HOH HOH M . 
O 5 HOH 130 530 512 HOH HOH M . 
O 5 HOH 131 531 514 HOH HOH M . 
O 5 HOH 132 532 515 HOH HOH M . 
O 5 HOH 133 533 518 HOH HOH M . 
O 5 HOH 134 534 520 HOH HOH M . 
O 5 HOH 135 535 527 HOH HOH M . 
O 5 HOH 136 536 529 HOH HOH M . 
O 5 HOH 137 537 531 HOH HOH M . 
O 5 HOH 138 538 544 HOH HOH M . 
O 5 HOH 139 539 547 HOH HOH M . 
O 5 HOH 140 540 548 HOH HOH M . 
O 5 HOH 141 541 550 HOH HOH M . 
O 5 HOH 142 542 553 HOH HOH M . 
O 5 HOH 143 543 555 HOH HOH M . 
O 5 HOH 144 544 557 HOH HOH M . 
O 5 HOH 145 545 572 HOH HOH M . 
O 5 HOH 146 546 577 HOH HOH M . 
O 5 HOH 147 547 586 HOH HOH M . 
O 5 HOH 148 548 588 HOH HOH M . 
O 5 HOH 149 549 598 HOH HOH M . 
O 5 HOH 150 550 603 HOH HOH M . 
O 5 HOH 151 551 615 HOH HOH M . 
O 5 HOH 152 552 631 HOH HOH M . 
O 5 HOH 153 553 636 HOH HOH M . 
O 5 HOH 154 554 646 HOH HOH M . 
O 5 HOH 155 555 649 HOH HOH M . 
O 5 HOH 156 556 650 HOH HOH M . 
O 5 HOH 157 557 664 HOH HOH M . 
O 5 HOH 158 558 665 HOH HOH M . 
O 5 HOH 159 559 668 HOH HOH M . 
O 5 HOH 160 560 676 HOH HOH M . 
O 5 HOH 161 561 680 HOH HOH M . 
O 5 HOH 162 562 683 HOH HOH M . 
O 5 HOH 163 563 685 HOH HOH M . 
O 5 HOH 164 564 686 HOH HOH M . 
O 5 HOH 165 565 689 HOH HOH M . 
O 5 HOH 166 566 690 HOH HOH M . 
O 5 HOH 167 567 691 HOH HOH M . 
O 5 HOH 168 568 702 HOH HOH M . 
O 5 HOH 169 569 704 HOH HOH M . 
O 5 HOH 170 570 708 HOH HOH M . 
O 5 HOH 171 571 712 HOH HOH M . 
O 5 HOH 172 572 713 HOH HOH M . 
O 5 HOH 173 573 716 HOH HOH M . 
O 5 HOH 174 574 719 HOH HOH M . 
O 5 HOH 175 575 721 HOH HOH M . 
O 5 HOH 176 576 724 HOH HOH M . 
O 5 HOH 177 577 726 HOH HOH M . 
O 5 HOH 178 578 731 HOH HOH M . 
O 5 HOH 179 579 732 HOH HOH M . 
O 5 HOH 180 580 740 HOH HOH M . 
O 5 HOH 181 581 745 HOH HOH M . 
O 5 HOH 182 582 748 HOH HOH M . 
O 5 HOH 183 583 750 HOH HOH M . 
O 5 HOH 184 584 755 HOH HOH M . 
O 5 HOH 185 585 758 HOH HOH M . 
O 5 HOH 186 586 760 HOH HOH M . 
O 5 HOH 187 587 762 HOH HOH M . 
O 5 HOH 188 588 764 HOH HOH M . 
O 5 HOH 189 589 770 HOH HOH M . 
O 5 HOH 190 590 778 HOH HOH M . 
O 5 HOH 191 591 781 HOH HOH M . 
O 5 HOH 192 592 783 HOH HOH M . 
O 5 HOH 193 593 789 HOH HOH M . 
O 5 HOH 194 594 791 HOH HOH M . 
O 5 HOH 195 595 792 HOH HOH M . 
O 5 HOH 196 596 795 HOH HOH M . 
O 5 HOH 197 597 801 HOH HOH M . 
P 5 HOH 1   401 1   HOH HOH I . 
P 5 HOH 2   402 2   HOH HOH I . 
P 5 HOH 3   403 5   HOH HOH I . 
P 5 HOH 4   404 7   HOH HOH I . 
P 5 HOH 5   405 11  HOH HOH I . 
P 5 HOH 6   406 15  HOH HOH I . 
P 5 HOH 7   407 20  HOH HOH I . 
P 5 HOH 8   408 25  HOH HOH I . 
P 5 HOH 9   409 27  HOH HOH I . 
P 5 HOH 10  410 29  HOH HOH I . 
P 5 HOH 11  411 30  HOH HOH I . 
P 5 HOH 12  412 33  HOH HOH I . 
P 5 HOH 13  413 43  HOH HOH I . 
P 5 HOH 14  414 53  HOH HOH I . 
P 5 HOH 15  415 67  HOH HOH I . 
P 5 HOH 16  416 72  HOH HOH I . 
P 5 HOH 17  417 81  HOH HOH I . 
P 5 HOH 18  418 83  HOH HOH I . 
P 5 HOH 19  419 88  HOH HOH I . 
P 5 HOH 20  420 94  HOH HOH I . 
P 5 HOH 21  421 96  HOH HOH I . 
P 5 HOH 22  422 100 HOH HOH I . 
P 5 HOH 23  423 109 HOH HOH I . 
P 5 HOH 24  424 111 HOH HOH I . 
P 5 HOH 25  425 115 HOH HOH I . 
P 5 HOH 26  426 116 HOH HOH I . 
P 5 HOH 27  427 119 HOH HOH I . 
P 5 HOH 28  428 122 HOH HOH I . 
P 5 HOH 29  429 130 HOH HOH I . 
P 5 HOH 30  430 132 HOH HOH I . 
P 5 HOH 31  431 139 HOH HOH I . 
P 5 HOH 32  432 141 HOH HOH I . 
P 5 HOH 33  433 145 HOH HOH I . 
P 5 HOH 34  434 146 HOH HOH I . 
P 5 HOH 35  435 147 HOH HOH I . 
P 5 HOH 36  436 153 HOH HOH I . 
P 5 HOH 37  437 157 HOH HOH I . 
P 5 HOH 38  438 159 HOH HOH I . 
P 5 HOH 39  439 180 HOH HOH I . 
P 5 HOH 40  440 181 HOH HOH I . 
P 5 HOH 41  441 188 HOH HOH I . 
P 5 HOH 42  442 189 HOH HOH I . 
P 5 HOH 43  443 190 HOH HOH I . 
P 5 HOH 44  444 195 HOH HOH I . 
P 5 HOH 45  445 197 HOH HOH I . 
P 5 HOH 46  446 198 HOH HOH I . 
P 5 HOH 47  447 203 HOH HOH I . 
P 5 HOH 48  448 208 HOH HOH I . 
P 5 HOH 49  449 209 HOH HOH I . 
P 5 HOH 50  450 215 HOH HOH I . 
P 5 HOH 51  451 226 HOH HOH I . 
P 5 HOH 52  452 235 HOH HOH I . 
P 5 HOH 53  453 237 HOH HOH I . 
P 5 HOH 54  454 242 HOH HOH I . 
P 5 HOH 55  455 245 HOH HOH I . 
P 5 HOH 56  456 253 HOH HOH I . 
P 5 HOH 57  457 264 HOH HOH I . 
P 5 HOH 58  458 265 HOH HOH I . 
P 5 HOH 59  459 274 HOH HOH I . 
P 5 HOH 60  460 283 HOH HOH I . 
P 5 HOH 61  461 284 HOH HOH I . 
P 5 HOH 62  462 285 HOH HOH I . 
P 5 HOH 63  463 289 HOH HOH I . 
P 5 HOH 64  464 290 HOH HOH I . 
P 5 HOH 65  465 291 HOH HOH I . 
P 5 HOH 66  466 293 HOH HOH I . 
P 5 HOH 67  467 295 HOH HOH I . 
P 5 HOH 68  468 296 HOH HOH I . 
P 5 HOH 69  469 308 HOH HOH I . 
P 5 HOH 70  470 309 HOH HOH I . 
P 5 HOH 71  471 310 HOH HOH I . 
P 5 HOH 72  472 317 HOH HOH I . 
P 5 HOH 73  473 320 HOH HOH I . 
P 5 HOH 74  474 323 HOH HOH I . 
P 5 HOH 75  475 331 HOH HOH I . 
P 5 HOH 76  476 338 HOH HOH I . 
P 5 HOH 77  477 340 HOH HOH I . 
P 5 HOH 78  478 342 HOH HOH I . 
P 5 HOH 79  479 343 HOH HOH I . 
P 5 HOH 80  480 344 HOH HOH I . 
P 5 HOH 81  481 349 HOH HOH I . 
P 5 HOH 82  482 355 HOH HOH I . 
P 5 HOH 83  483 357 HOH HOH I . 
P 5 HOH 84  484 361 HOH HOH I . 
P 5 HOH 85  485 363 HOH HOH I . 
P 5 HOH 86  486 367 HOH HOH I . 
P 5 HOH 87  487 368 HOH HOH I . 
P 5 HOH 88  488 369 HOH HOH I . 
P 5 HOH 89  489 370 HOH HOH I . 
P 5 HOH 90  490 376 HOH HOH I . 
P 5 HOH 91  491 379 HOH HOH I . 
P 5 HOH 92  492 391 HOH HOH I . 
P 5 HOH 93  493 394 HOH HOH I . 
P 5 HOH 94  494 407 HOH HOH I . 
P 5 HOH 95  495 411 HOH HOH I . 
P 5 HOH 96  496 414 HOH HOH I . 
P 5 HOH 97  497 418 HOH HOH I . 
P 5 HOH 98  498 419 HOH HOH I . 
P 5 HOH 99  499 425 HOH HOH I . 
P 5 HOH 100 500 427 HOH HOH I . 
P 5 HOH 101 501 429 HOH HOH I . 
P 5 HOH 102 502 430 HOH HOH I . 
P 5 HOH 103 503 432 HOH HOH I . 
P 5 HOH 104 504 436 HOH HOH I . 
P 5 HOH 105 505 439 HOH HOH I . 
P 5 HOH 106 506 440 HOH HOH I . 
P 5 HOH 107 507 441 HOH HOH I . 
P 5 HOH 108 508 445 HOH HOH I . 
P 5 HOH 109 509 448 HOH HOH I . 
P 5 HOH 110 510 449 HOH HOH I . 
P 5 HOH 111 511 458 HOH HOH I . 
P 5 HOH 112 512 459 HOH HOH I . 
P 5 HOH 113 513 460 HOH HOH I . 
P 5 HOH 114 514 461 HOH HOH I . 
P 5 HOH 115 515 464 HOH HOH I . 
P 5 HOH 116 516 465 HOH HOH I . 
P 5 HOH 117 517 470 HOH HOH I . 
P 5 HOH 118 518 484 HOH HOH I . 
P 5 HOH 119 519 487 HOH HOH I . 
P 5 HOH 120 520 488 HOH HOH I . 
P 5 HOH 121 521 493 HOH HOH I . 
P 5 HOH 122 522 494 HOH HOH I . 
P 5 HOH 123 523 499 HOH HOH I . 
P 5 HOH 124 524 506 HOH HOH I . 
P 5 HOH 125 525 510 HOH HOH I . 
P 5 HOH 126 526 521 HOH HOH I . 
P 5 HOH 127 527 528 HOH HOH I . 
P 5 HOH 128 528 530 HOH HOH I . 
P 5 HOH 129 529 532 HOH HOH I . 
P 5 HOH 130 530 536 HOH HOH I . 
P 5 HOH 131 531 539 HOH HOH I . 
P 5 HOH 132 532 545 HOH HOH I . 
P 5 HOH 133 533 546 HOH HOH I . 
P 5 HOH 134 534 549 HOH HOH I . 
P 5 HOH 135 535 556 HOH HOH I . 
P 5 HOH 136 536 563 HOH HOH I . 
P 5 HOH 137 537 564 HOH HOH I . 
P 5 HOH 138 538 567 HOH HOH I . 
P 5 HOH 139 539 569 HOH HOH I . 
P 5 HOH 140 540 574 HOH HOH I . 
P 5 HOH 141 541 578 HOH HOH I . 
P 5 HOH 142 542 579 HOH HOH I . 
P 5 HOH 143 543 580 HOH HOH I . 
P 5 HOH 144 544 581 HOH HOH I . 
P 5 HOH 145 545 583 HOH HOH I . 
P 5 HOH 146 546 589 HOH HOH I . 
P 5 HOH 147 547 593 HOH HOH I . 
P 5 HOH 148 548 599 HOH HOH I . 
P 5 HOH 149 549 602 HOH HOH I . 
P 5 HOH 150 550 605 HOH HOH I . 
P 5 HOH 151 551 606 HOH HOH I . 
P 5 HOH 152 552 607 HOH HOH I . 
P 5 HOH 153 553 610 HOH HOH I . 
P 5 HOH 154 554 611 HOH HOH I . 
P 5 HOH 155 555 616 HOH HOH I . 
P 5 HOH 156 556 617 HOH HOH I . 
P 5 HOH 157 557 619 HOH HOH I . 
P 5 HOH 158 558 626 HOH HOH I . 
P 5 HOH 159 559 628 HOH HOH I . 
P 5 HOH 160 560 632 HOH HOH I . 
P 5 HOH 161 561 634 HOH HOH I . 
P 5 HOH 162 562 635 HOH HOH I . 
P 5 HOH 163 563 638 HOH HOH I . 
P 5 HOH 164 564 640 HOH HOH I . 
P 5 HOH 165 565 642 HOH HOH I . 
P 5 HOH 166 566 669 HOH HOH I . 
P 5 HOH 167 567 671 HOH HOH I . 
P 5 HOH 168 568 672 HOH HOH I . 
P 5 HOH 169 569 673 HOH HOH I . 
P 5 HOH 170 570 674 HOH HOH I . 
P 5 HOH 171 571 681 HOH HOH I . 
P 5 HOH 172 572 688 HOH HOH I . 
P 5 HOH 173 573 692 HOH HOH I . 
P 5 HOH 174 574 694 HOH HOH I . 
P 5 HOH 175 575 697 HOH HOH I . 
P 5 HOH 176 576 698 HOH HOH I . 
P 5 HOH 177 577 700 HOH HOH I . 
P 5 HOH 178 578 706 HOH HOH I . 
P 5 HOH 179 579 710 HOH HOH I . 
P 5 HOH 180 580 718 HOH HOH I . 
P 5 HOH 181 581 720 HOH HOH I . 
P 5 HOH 182 582 722 HOH HOH I . 
P 5 HOH 183 583 728 HOH HOH I . 
P 5 HOH 184 584 729 HOH HOH I . 
P 5 HOH 185 585 730 HOH HOH I . 
P 5 HOH 186 586 733 HOH HOH I . 
P 5 HOH 187 587 736 HOH HOH I . 
P 5 HOH 188 588 746 HOH HOH I . 
P 5 HOH 189 589 749 HOH HOH I . 
P 5 HOH 190 590 753 HOH HOH I . 
P 5 HOH 191 591 765 HOH HOH I . 
P 5 HOH 192 592 774 HOH HOH I . 
P 5 HOH 193 593 776 HOH HOH I . 
P 5 HOH 194 594 779 HOH HOH I . 
P 5 HOH 195 595 785 HOH HOH I . 
P 5 HOH 196 596 786 HOH HOH I . 
P 5 HOH 197 597 787 HOH HOH I . 
P 5 HOH 198 598 802 HOH HOH I . 
P 5 HOH 199 599 805 HOH HOH I . 
Q 5 HOH 1   401 259 HOH HOH Q . 
Q 5 HOH 2   402 278 HOH HOH Q . 
Q 5 HOH 3   403 383 HOH HOH Q . 
Q 5 HOH 4   404 401 HOH HOH Q . 
Q 5 HOH 5   405 435 HOH HOH Q . 
Q 5 HOH 6   406 451 HOH HOH Q . 
Q 5 HOH 7   407 453 HOH HOH Q . 
Q 5 HOH 8   408 474 HOH HOH Q . 
Q 5 HOH 9   409 582 HOH HOH Q . 
Q 5 HOH 10  410 643 HOH HOH Q . 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA trimeric 3 
2 author_and_software_defined_assembly PISA trimeric 3 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,C,G,H,I,L,M,N 
2 1 D,E,F,J,K,O,P,Q   
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4590  ? 
1 MORE         -61   ? 
1 'SSA (A^2)'  19270 ? 
2 'ABSA (A^2)' 4490  ? 
2 MORE         -55   ? 
2 'SSA (A^2)'  19230 ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_pdbx_struct_conn_angle.id                    1 
_pdbx_struct_conn_angle.ptnr1_label_atom_id   O 
_pdbx_struct_conn_angle.ptnr1_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr1_label_asym_id   P 
_pdbx_struct_conn_angle.ptnr1_label_comp_id   HOH 
_pdbx_struct_conn_angle.ptnr1_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id    I 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id    HOH 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id     434 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr1_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr2_label_atom_id   CA 
_pdbx_struct_conn_angle.ptnr2_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr2_label_asym_id   K 
_pdbx_struct_conn_angle.ptnr2_label_comp_id   CA 
_pdbx_struct_conn_angle.ptnr2_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id    I 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id    CA 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id     301 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr2_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr3_label_atom_id   O 
_pdbx_struct_conn_angle.ptnr3_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr3_label_asym_id   P 
_pdbx_struct_conn_angle.ptnr3_label_comp_id   HOH 
_pdbx_struct_conn_angle.ptnr3_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id    I 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id    HOH 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id     436 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr3_symmetry        1_555 
_pdbx_struct_conn_angle.value                 58.4 
_pdbx_struct_conn_angle.value_esd             ? 
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2013-07-31 
2 'Structure model' 1 1 2013-09-04 
3 'Structure model' 1 2 2023-09-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references'    
2 3 'Structure model' 'Data collection'        
3 3 'Structure model' 'Database references'    
4 3 'Structure model' 'Derived calculations'   
5 3 'Structure model' 'Refinement description' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 3 'Structure model' chem_comp_atom                
2 3 'Structure model' chem_comp_bond                
3 3 'Structure model' database_2                    
4 3 'Structure model' pdbx_initial_refinement_model 
5 3 'Structure model' pdbx_struct_conn_angle        
6 3 'Structure model' struct_conn                   
7 3 'Structure model' struct_site                   
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  3 'Structure model' '_database_2.pdbx_DOI'                      
2  3 'Structure model' '_database_2.pdbx_database_accession'       
3  3 'Structure model' '_pdbx_struct_conn_angle.ptnr1_auth_seq_id' 
4  3 'Structure model' '_pdbx_struct_conn_angle.ptnr3_auth_seq_id' 
5  3 'Structure model' '_struct_conn.pdbx_dist_value'              
6  3 'Structure model' '_struct_conn.ptnr1_auth_asym_id'           
7  3 'Structure model' '_struct_conn.ptnr1_label_asym_id'          
8  3 'Structure model' '_struct_conn.ptnr2_auth_asym_id'           
9  3 'Structure model' '_struct_conn.ptnr2_auth_seq_id'            
10 3 'Structure model' '_struct_conn.ptnr2_label_asym_id'          
11 3 'Structure model' '_struct_site.pdbx_auth_asym_id'            
12 3 'Structure model' '_struct_site.pdbx_auth_comp_id'            
13 3 'Structure model' '_struct_site.pdbx_auth_seq_id'             
# 
loop_
_software.name 
_software.classification 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
Blu-Ice  'data collection' like                         ? 1 
MOLREP   phasing           .                            ? 2 
PHENIX   refinement        '(phenix.refine: 1.7.3_928)' ? 3 
HKL-2000 'data reduction'  .                            ? 4 
HKL-2000 'data scaling'    .                            ? 5 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 SG  I CYS 128 ? ? CB I CYS 213 ? ? 1.41 
2  1 O   I HOH 566 ? ? O  I HOH 573 ? ? 1.81 
3  1 O   H HOH 585 ? ? O  H HOH 586 ? ? 1.81 
4  1 O   I HOH 588 ? ? O  I HOH 592 ? ? 1.88 
5  1 O   H THR 52  A ? O  H HOH 516 ? ? 1.89 
6  1 CB  I CYS 128 ? ? SG I CYS 213 ? ? 1.89 
7  1 NZ  L LYS 138 ? ? O  L HOH 523 ? ? 1.94 
8  1 O   L HOH 587 ? ? O  L HOH 590 ? ? 1.96 
9  1 OD1 M ASN 137 ? ? O  M HOH 553 ? ? 1.98 
10 1 O   L HOH 575 ? ? O  L HOH 577 ? ? 1.98 
11 1 O   H HOH 580 ? ? O  H HOH 592 ? ? 1.99 
12 1 O   L HOH 579 ? ? O  L HOH 586 ? ? 2.00 
13 1 OE1 I GLU 52  ? ? OG I SER 54  ? ? 2.03 
14 1 O   M HOH 542 ? ? O  M HOH 543 ? ? 2.03 
15 1 O   M HOH 588 ? ? O  M HOH 596 ? ? 2.03 
16 1 OD2 I ASP 130 ? ? O  I HOH 498 ? ? 2.05 
17 1 O   I HOH 584 ? ? O  I HOH 598 ? ? 2.05 
18 1 OD1 H ASN 161 ? ? O  H HOH 513 ? ? 2.07 
19 1 O   I CYS 128 ? ? O  I HOH 583 ? ? 2.11 
20 1 OD1 L ASN 137 ? ? O  L HOH 532 ? ? 2.12 
21 1 O   I HOH 565 ? ? O  I HOH 597 ? ? 2.13 
22 1 O   H SER 186 ? ? O  H HOH 565 ? ? 2.13 
23 1 O   L HOH 543 ? ? O  L HOH 594 ? ? 2.16 
24 1 OE1 H GLU 52  ? ? OG H SER 54  ? ? 2.16 
25 1 NZ  M LYS 63  ? ? O  M HOH 522 ? ? 2.16 
26 1 O   H HOH 485 ? ? O  H HOH 524 ? ? 2.18 
27 1 O   I HOH 591 ? ? O  I HOH 593 ? ? 2.18 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    L 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     524 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    M 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     534 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_556 
_pdbx_validate_symm_contact.dist              1.78 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CD L ARG 107 ? ? NE L ARG 107 ? ? CZ  L ARG 107 ? ? 135.35 123.60 11.75 1.40 N 
2 1 NE L ARG 107 ? ? CZ L ARG 107 ? ? NH1 L ARG 107 ? ? 110.92 120.30 -9.38 0.50 N 
3 1 NE L ARG 107 ? ? CZ L ARG 107 ? ? NH2 L ARG 107 ? ? 129.07 120.30 8.77  0.50 N 
4 1 NE M ARG 107 ? ? CZ M ARG 107 ? ? NH1 M ARG 107 ? ? 124.47 120.30 4.17  0.50 N 
5 1 NE M ARG 107 ? ? CZ M ARG 107 ? ? NH2 M ARG 107 ? ? 115.70 120.30 -4.60 0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN L 30  ? ? 59.99   -3.21   
2  1 ALA L 51  ? ? 72.95   -40.09  
3  1 SER L 52  ? ? -143.61 -0.98   
4  1 ALA L 84  ? ? -170.70 -177.13 
5  1 LYS L 138 ? ? 49.55   71.15   
6  1 CYS L 170 ? ? 71.70   -1.64   
7  1 SER H 54  ? ? 78.13   -36.52  
8  1 ASP H 55  ? ? 39.48   49.09   
9  1 CYS H 128 ? ? -56.90  99.98   
10 1 PRO H 132 ? ? -43.72  164.45  
11 1 SER H 133 ? ? -150.48 -158.48 
12 1 SER H 134 ? ? 66.42   -76.57  
13 1 SER H 188 ? ? -120.93 -103.09 
14 1 SER P 306 ? ? -151.58 -152.24 
15 1 ASN M 30  ? ? 58.95   -3.42   
16 1 ALA M 51  ? ? 73.94   -39.72  
17 1 ALA M 84  ? ? -171.31 -176.81 
18 1 CYS M 170 ? ? 74.01   -1.76   
19 1 ASP I 55  ? ? 39.43   44.72   
20 1 PRO I 132 ? ? -91.19  -101.91 
21 1 SER I 134 ? ? -145.97 -69.03  
22 1 SER I 211 ? ? -5.77   -77.09  
23 1 SER Q 306 ? ? -151.36 -150.24 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 P ASN 301 ? C ASN 1  
2  1 Y 1 P ASN 302 ? C ASN 2  
3  1 Y 1 P ARG 315 ? C ARG 13 
4  1 Y 1 P ALA 316 ? C ALA 14 
5  1 Y 1 P PHE 317 ? C PHE 15 
6  1 Y 1 P TYR 318 ? C TYR 16 
7  1 Y 1 P THR 319 ? C THR 17 
8  1 Y 1 P THR 320 ? C THR 18 
9  1 Y 1 P GLY 321 ? C GLY 19 
10 1 Y 1 P GLU 322 ? C GLU 20 
11 1 Y 1 P ILE 323 ? C ILE 21 
12 1 Y 1 P ILE 324 ? C ILE 22 
13 1 Y 1 P GLY 325 ? C GLY 23 
14 1 Y 1 Q ASN 301 ? F ASN 1  
15 1 Y 1 Q ASN 302 ? F ASN 2  
16 1 Y 1 Q ARG 315 ? F ARG 13 
17 1 Y 1 Q ALA 316 ? F ALA 14 
18 1 Y 1 Q PHE 317 ? F PHE 15 
19 1 Y 1 Q TYR 318 ? F TYR 16 
20 1 Y 1 Q THR 319 ? F THR 17 
21 1 Y 1 Q THR 320 ? F THR 18 
22 1 Y 1 Q GLY 321 ? F GLY 19 
23 1 Y 1 Q GLU 322 ? F GLU 20 
24 1 Y 1 Q ILE 323 ? F ILE 21 
25 1 Y 1 Q ILE 324 ? F ILE 22 
26 1 Y 1 Q GLY 325 ? F GLY 23 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
PHE N    N  N N 251 
PHE CA   C  N S 252 
PHE C    C  N N 253 
PHE O    O  N N 254 
PHE CB   C  N N 255 
PHE CG   C  Y N 256 
PHE CD1  C  Y N 257 
PHE CD2  C  Y N 258 
PHE CE1  C  Y N 259 
PHE CE2  C  Y N 260 
PHE CZ   C  Y N 261 
PHE OXT  O  N N 262 
PHE H    H  N N 263 
PHE H2   H  N N 264 
PHE HA   H  N N 265 
PHE HB2  H  N N 266 
PHE HB3  H  N N 267 
PHE HD1  H  N N 268 
PHE HD2  H  N N 269 
PHE HE1  H  N N 270 
PHE HE2  H  N N 271 
PHE HZ   H  N N 272 
PHE HXT  H  N N 273 
PRO N    N  N N 274 
PRO CA   C  N S 275 
PRO C    C  N N 276 
PRO O    O  N N 277 
PRO CB   C  N N 278 
PRO CG   C  N N 279 
PRO CD   C  N N 280 
PRO OXT  O  N N 281 
PRO H    H  N N 282 
PRO HA   H  N N 283 
PRO HB2  H  N N 284 
PRO HB3  H  N N 285 
PRO HG2  H  N N 286 
PRO HG3  H  N N 287 
PRO HD2  H  N N 288 
PRO HD3  H  N N 289 
PRO HXT  H  N N 290 
SER N    N  N N 291 
SER CA   C  N S 292 
SER C    C  N N 293 
SER O    O  N N 294 
SER CB   C  N N 295 
SER OG   O  N N 296 
SER OXT  O  N N 297 
SER H    H  N N 298 
SER H2   H  N N 299 
SER HA   H  N N 300 
SER HB2  H  N N 301 
SER HB3  H  N N 302 
SER HG   H  N N 303 
SER HXT  H  N N 304 
THR N    N  N N 305 
THR CA   C  N S 306 
THR C    C  N N 307 
THR O    O  N N 308 
THR CB   C  N R 309 
THR OG1  O  N N 310 
THR CG2  C  N N 311 
THR OXT  O  N N 312 
THR H    H  N N 313 
THR H2   H  N N 314 
THR HA   H  N N 315 
THR HB   H  N N 316 
THR HG1  H  N N 317 
THR HG21 H  N N 318 
THR HG22 H  N N 319 
THR HG23 H  N N 320 
THR HXT  H  N N 321 
TRP N    N  N N 322 
TRP CA   C  N S 323 
TRP C    C  N N 324 
TRP O    O  N N 325 
TRP CB   C  N N 326 
TRP CG   C  Y N 327 
TRP CD1  C  Y N 328 
TRP CD2  C  Y N 329 
TRP NE1  N  Y N 330 
TRP CE2  C  Y N 331 
TRP CE3  C  Y N 332 
TRP CZ2  C  Y N 333 
TRP CZ3  C  Y N 334 
TRP CH2  C  Y N 335 
TRP OXT  O  N N 336 
TRP H    H  N N 337 
TRP H2   H  N N 338 
TRP HA   H  N N 339 
TRP HB2  H  N N 340 
TRP HB3  H  N N 341 
TRP HD1  H  N N 342 
TRP HE1  H  N N 343 
TRP HE3  H  N N 344 
TRP HZ2  H  N N 345 
TRP HZ3  H  N N 346 
TRP HH2  H  N N 347 
TRP HXT  H  N N 348 
TYR N    N  N N 349 
TYR CA   C  N S 350 
TYR C    C  N N 351 
TYR O    O  N N 352 
TYR CB   C  N N 353 
TYR CG   C  Y N 354 
TYR CD1  C  Y N 355 
TYR CD2  C  Y N 356 
TYR CE1  C  Y N 357 
TYR CE2  C  Y N 358 
TYR CZ   C  Y N 359 
TYR OH   O  N N 360 
TYR OXT  O  N N 361 
TYR H    H  N N 362 
TYR H2   H  N N 363 
TYR HA   H  N N 364 
TYR HB2  H  N N 365 
TYR HB3  H  N N 366 
TYR HD1  H  N N 367 
TYR HD2  H  N N 368 
TYR HE1  H  N N 369 
TYR HE2  H  N N 370 
TYR HH   H  N N 371 
TYR HXT  H  N N 372 
VAL N    N  N N 373 
VAL CA   C  N S 374 
VAL C    C  N N 375 
VAL O    O  N N 376 
VAL CB   C  N N 377 
VAL CG1  C  N N 378 
VAL CG2  C  N N 379 
VAL OXT  O  N N 380 
VAL H    H  N N 381 
VAL H2   H  N N 382 
VAL HA   H  N N 383 
VAL HB   H  N N 384 
VAL HG11 H  N N 385 
VAL HG12 H  N N 386 
VAL HG13 H  N N 387 
VAL HG21 H  N N 388 
VAL HG22 H  N N 389 
VAL HG23 H  N N 390 
VAL HXT  H  N N 391 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'CALCIUM ION' CA  
5 water         HOH 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2X71 
_pdbx_initial_refinement_model.details          'PDB ENTRY 2X71' 
# 
