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# Copyright (C) 2014-2015 by OpenEye Scientific Software, Inc.
#**********************************************************************

# Functional Group Filters, Initial Set

RULE 0 pains_pre_acid_halide
RULE 0 pains_pre_het_halide
RULE 0 pains_pre_acyl_carbamate1
RULE 0 pains_pre_acyl_carbamate2
RULE 0 pains_pre_acyl_cyanide
RULE 0 pains_pre_aldehyde
RULE 0 pains_pre_long_aliphatic_chain
RULE 0 pains_pre_alkyl_bromide1
RULE 0 pains_pre_alkyl_chloride1
RULE 0 pains_pre_anhydrides
RULE 0 pains_pre_azido
RULE 0 pains_pre_aziridine
RULE 0 pains_pre_boron
RULE 0 pains_pre_carbamic_acids
RULE 0 pains_pre_sulfur_cation
RULE 0 pains_pre_oxygen_cation
RULE 0 pains_pre_trivalent_oxygen
RULE 0 pains_pre_halogen_cation
RULE 0 pains_pre_sulfur_V
RULE 0 pains_pre_cyanamide
RULE 0 pains_pre_cyanate
RULE 0 pains_pre_thiocyanate
RULE 0 pains_pre_cyanohydrin
RULE 0 pains_pre_cyclohexadiene1_3
RULE 0 pains_pre_cyclohexadiene1_4
RULE 0 pains_pre_disulfide
RULE 0 pains_pre_trisulfide
RULE 0 pains_pre_enamines
RULE 0 pains_pre_thioester1
RULE 0 pains_pre_vinylester
RULE 0 pains_pre_hydrazine
RULE 0 pains_pre_oxazine
RULE 0 pains_pre_imidoyl_halide
RULE 0 pains_pre_ketene
RULE 0 pains_pre_michael_acceptor1
RULE 0 pains_pre_michael_acceptor2
RULE 0 pains_pre_michael_acceptor3
RULE 0 pains_pre_nitros
RULE 0 pains_pre_nitroso
RULE 0 pains_pre_peroxide
RULE 0 pains_pre_silicon
RULE 0 pains_pre_thiol
RULE 0 pains_pre_trihaloimidate
RULE 2 pains_pre_carboxylic_acid
RULE 2 pains_pre_thioether
RULE 1 pains_pre_bromo
RULE 3 pains_pre_chloro
RULE 5 pains_pre_fluoro

# Functional Group Filters, Expanded Set

RULE 0 pains_pre_thioacid_halide
RULE 0 pains_pre_acrylamide
RULE 0 pains_pre_thioacrylamide
RULE 0 pains_pre_vinylcyanide
RULE 0 pains_pre_vinylpyridine
RULE 0 pains_pre_vinylthioketone
RULE 0 pains_pre_acyl_carbamates3
RULE 0 pains_pre_acyl_hydrazone1
RULE 0 pains_pre_acyl_hydrazone2
RULE 0 pains_pre_acyl_hydrazide
RULE 0 pains_pre_acyl_imide
RULE 0 pains_pre_acyl_sulfonamide
RULE 0 pains_pre_sulfocyanide
RULE 0 pains_pre_thioacylcyanide
RULE 0 pains_pre_acylimine
RULE 0 pains_pre_thioaldehyde
RULE 0 pains_pre_alkyl_bromide2
RULE 0 pains_pre_alkyl_chloride2
RULE 0 pains_pre_amidotetrazole
RULE 0 pains_pre_basic_amine1
RULE 0 pains_pre_basic_amine2
RULE 0 pains_pre_basic_amine3
RULE 0 pains_pre_azo
RULE 0 pains_pre_hetero_cyclopropyl
RULE 0 pains_pre_beta_lactam
RULE 0 pains_pre_beta_heteroketone
RULE 0 pains_pre_beta_heterothioketone
RULE 0 pains_pre_biotin
RULE 0 pains_pre_carbazide
RULE 0 pains_pre_carbon_cation
RULE 0 pains_pre_carbon_anion
RULE 0 pains_pre_catechol
RULE 0 pains_pre_crown_ether
RULE 0 pains_pre_dialkyne
RULE 0 pains_pre_diketo
RULE 0 pains_pre_ketocarboxyl
RULE 0 pains_pre_ketosulfoxide
RULE 0 pains_pre_beta_ketothiocarbonyl
RULE 0 pains_pre_2_4_dione
RULE 0 pains_pre_beta_ketosulfoxide
RULE 0 pains_pre_beta_ketocyanide
RULE 0 pains_pre_beta_ketotrihalomethyl
RULE 0 pains_pre_acetoxyacetamide
RULE 0 pains_pre_thioester2
RULE 0 pains_pre_thioester3
RULE 0 pains_pre_benzylester1
RULE 0 pains_pre_benzylester2
RULE 0 pains_pre_trihalomethylester
RULE 0 pains_pre_carboxymethylester
RULE 0 pains_pre_cyanomethylester
RULE 0 pains_pre_ketoester
RULE 0 pains_pre_sulfonoester
RULE 0 pains_pre_beta_sulfonoester
RULE 0 pains_pre_beta_cyanoester
RULE 0 pains_pre_beta_trihalomethylester
RULE 0 pains_pre_beta_carboxy_diacetamide
RULE 0 pains_pre_1_2_dihaloring
RULE 0 pains_pre_1_3_dihaloring
RULE 0 pains_pre_1_4_dihaloring
RULE 0 pains_pre_1_2_4_trihaloring
RULE 0 pains_pre_1_2_3_trihaloring
RULE 0 pains_pre_1_2_5_trichlororing
RULE 0 pains_pre_hydroxylamine
RULE 0 pains_pre_hydroxamic_acid
RULE 0 pains_pre_imide
RULE 0 pains_pre_imine1
RULE 0 pains_pre_imine2
RULE 0 pains_pre_imine3
RULE 0 pains_pre_iodine
RULE 0 pains_pre_maleamide1
RULE 0 pains_pre_maleamide2
RULE 0 pains_pre_unsat_nitrile_ketone1
RULE 0 pains_pre_unsat_nitrile_ketone2
RULE 0 pains_pre_linear_diactivated_A
RULE 0 pains_pre_linear_diactivated_B
RULE 0 pains_pre_linear_diactivated_C1
RULE 0 pains_pre_linear_diactivated_C2
RULE 0 pains_pre_linear_diactivated_C3
RULE 0 pains_pre_linear_diactivated_C4
RULE 0 pains_pre_activated_coumarin
RULE 0 pains_pre_activated_chromone
RULE 0 pains_pre_mercaptothiazole
RULE 0 pains_pre_quat_pyridine
RULE 0 pains_pre_n_acyl
RULE 0 pains_pre_naphthylamine1
RULE 0 pains_pre_naphthylamine2
RULE 0 pains_pre_naphthylamine3
RULE 0 pains_pre_naphthylamine4
RULE 0 pains_pre_naphthylamine5
RULE 0 pains_pre_hetero_nitro
RULE 0 pains_pre_n_oxide
RULE 0 pains_pre_phosphorus
RULE 0 pains_pre_quaternary_nitrogen
RULE 0 pains_pre_sulfur_oxygen_single_bond
RULE 0 pains_pre_sulfur_nitrogen_single_bond
RULE 0 pains_pre_sulfur_nitrogen_surrogate
RULE 0 pains_pre_thiocarbonyl
RULE 0 pains_pre_trichloromethyl
RULE 0 pains_pre_dihaloketone
RULE 0 pains_pre_isonitrile
RULE 0 pains_pre_sulf_or_halo_activated_ring1
RULE 0 pains_pre_sulf_or_halo_activated_ring2
RULE 0 pains_pre_sulf_or_halo_activated_ring3
RULE 0 pains_pre_sulf_or_halo_activated_ring4
RULE 0 pains_pre_sulf_or_halo_activated_ring5
RULE 0 pains_pre_sulf_or_halo_activated_ring6
RULE 0 pains_pre_sulf_or_halo_activated_ring7
RULE 0 pains_pre_sulf_or_halo_activated_ring8
RULE 0 pains_pre_sulf_or_halo_activated_ring9
RULE 0 pains_pre_sulf_or_halo_activated_ring10
RULE 0 pains_pre_sulf_or_halo_activated_ring11
RULE 0 pains_pre_sulf_or_halo_activated_ring12
RULE 0 pains_pre_sulf_or_halo_activated_ring13
RULE 0 pains_pre_sulf_or_halo_activated_ring14
RULE 0 pains_pre_fluorosulfonamide
RULE 0 pains_pre_thiazolium_halide
RULE 0 pains_pre_haloenamine1
RULE 0 pains_pre_haloenamine2
RULE 0 pains_pre_haloenamine3
RULE 0 pains_pre_terminal_acetylene
RULE 1 pains_pre_thiophene
RULE 1 pains_pre_furan
RULE 2 pains_pre_nitrile
RULE 2 pains_pre_ester

# Filter Family A (named after regID in original paper)

RULE 0 pains_a_ene_six_het_A
RULE 0 pains_a_hzone_phenol_A
RULE 0 pains_a_anil_di_alk_A
RULE 0 pains_a_indol_3yl_alk
RULE 0 pains_a_quinone_A
RULE 0 pains_a_azo_A
RULE 0 pains_a_imine_one_A
RULE 0 pains_a_mannich_A
RULE 0 pains_a_anil_di_alk_B
RULE 0 pains_a_anil_di_alk_C
RULE 0 pains_a_ene_rhod_A
RULE 0 pains_a_hzone_phenol_B
RULE 0 pains_a_ene_five_het_A
RULE 0 pains_a_anil_di_alk_D
RULE 0 pains_a_imine_one_isatin
RULE 0 pains_a_anil_di_alk_E

# Filter Family B (named after regID in original paper)

RULE 0 pains_b_thiaz_ene_A
RULE 0 pains_b_pyrrole_A
RULE 0 pains_b_catechol_A
RULE 0 pains_b_ene_five_het_B
RULE 0 pains_b_imine_one_fives
RULE 0 pains_b_ene_five_het_C
RULE 0 pains_b_hzone_pipzn
RULE 0 pains_b_keto_keto_beta_A
RULE 0 pains_b_hzone_pyrrol
RULE 0 pains_b_ene_one_ene_A
RULE 0 pains_b_cyano_ene_amine_A
RULE 0 pains_b_ene_five_one_A
RULE 0 pains_b_cyano_pyridone_A
RULE 0 pains_b_anil_alk_ene
RULE 0 pains_b_amino_acridine_Ab
RULE 0 pains_b_ene_five_het_D
RULE 0 pains_b_thiophene_amino_Aa
RULE 0 pains_b_ene_five_het_E
RULE 0 pains_b_sulfonamide_A
RULE 0 pains_b_thio_ketone
RULE 0 pains_b_sulfonamide_B
RULE 0 pains_b_anil_no_alk
RULE 0 pains_b_thiophene_amino_Ab
RULE 0 pains_b_het_pyridiniums_A
RULE 0 pains_b_anthranil_one_A
RULE 0 pains_b_cyano_imine_A
RULE 0 pains_b_diazox_sulfon_A
RULE 0 pains_b_hzone_anil_di_alk
RULE 0 pains_b_rhod_sat_A
RULE 0 pains_b_hzone_enamin
RULE 0 pains_b_pyrrole_B
RULE 0 pains_b_thiophene_hydroxy
RULE 0 pains_b_cyano_pyridone_B
RULE 0 pains_b_imine_one_sixes
RULE 0 pains_b_dyes5A
RULE 0 pains_b_naphth_amino_A
RULE 0 pains_b_naphth_amino_B
RULE 0 pains_b_ene_one_ester
RULE 0 pains_b_thio_dibenzo
RULE 0 pains_b_cyano_cyano_A
RULE 0 pains_b_hzone_acyl_naphthol
RULE 0 pains_b_het_65_A
RULE 0 pains_b_imidazole_A
RULE 0 pains_b_ene_cyano_A
RULE 0 pains_b_anthranil_acid_A
RULE 0 pains_b_dyes3A
RULE 0 pains_b_dhp_bis_amino_CN
RULE 0 pains_b_het_6_tetrazine
RULE 0 pains_b_ene_one_hal
RULE 0 pains_b_cyano_imine_B
RULE 0 pains_b_thiaz_ene_B
RULE 0 pains_b_ene_rhod_B
RULE 0 pains_b_thio_carbonate_A
RULE 0 pains_b_anil_di_alk_furan_A
RULE 0 pains_b_ene_five_het_F

# Filter Family C (named after regID in original paper)

RULE 0 pains_c_anil_di_alk_F
RULE 0 pains_c_hzone_anil
RULE 0 pains_c_het_5_pyrazole_OH
RULE 0 pains_c_het_thio_666_A
RULE 0 pains_c_styrene_A
RULE 0 pains_c_ene_rhod_C
RULE 0 pains_c_dhp_amino_CN_A
RULE 0 pains_c_cyano_imine_C
RULE 0 pains_c_thio_urea_A
RULE 0 pains_c_thiophene_amino_B
RULE 0 pains_c_keto_keto_beta_B
RULE 0 pains_c_keto_phenone_A
RULE 0 pains_c_cyano_pyridone_C
RULE 0 pains_c_thiaz_ene_C
RULE 0 pains_c_hzone_thiophene_A
RULE 0 pains_c_ene_quin_methide
RULE 0 pains_c_het_thio_676_A
RULE 0 pains_c_ene_five_het_G
RULE 0 pains_c_acyl_het_A
RULE 0 pains_c_anil_di_alk_G
RULE 0 pains_c_dhp_keto_A
RULE 0 pains_c_thio_urea_B
RULE 0 pains_c_anil_alk_bim
RULE 0 pains_c_imine_imine_A
RULE 0 pains_c_thio_urea_C
RULE 0 pains_c_imine_one_fives_B
RULE 0 pains_c_dhp_amino_CN_B
RULE 0 pains_c_anil_OC_no_alk_A
RULE 0 pains_c_het_thio_66_one
RULE 0 pains_c_styrene_B
RULE 0 pains_c_het_thio_5_A
RULE 0 pains_c_anil_di_alk_ene_A
RULE 0 pains_c_ene_rhod_D
RULE 0 pains_c_ene_rhod_E
RULE 0 pains_c_anil_OH_alk_A
RULE 0 pains_c_pyrrole_C
RULE 0 pains_c_thio_urea_D
RULE 0 pains_c_thiaz_ene_D
RULE 0 pains_c_ene_rhod_F
RULE 0 pains_c_thiaz_ene_E
RULE 0 pains_c_het_65_B
RULE 0 pains_c_keto_keto_beta_C
RULE 0 pains_c_het_66_A
RULE 0 pains_c_thio_urea_E
RULE 0 pains_c_thiophene_amino_C
RULE 0 pains_c_hzone_phenone
RULE 0 pains_c_ene_rhod_G
RULE 0 pains_c_ene_cyano_B
RULE 0 pains_c_dhp_amino_CN_C
RULE 0 pains_c_het_5_A
RULE 0 pains_c_ene_five_het_H
RULE 0 pains_c_thio_amide_A
RULE 0 pains_c_ene_cyano_C
RULE 0 pains_c_hzone_furan_A
RULE 0 pains_c_anil_di_alk_H
RULE 0 pains_c_het_65_C
RULE 0 pains_c_thio_urea_F
RULE 0 pains_c_ene_five_het_I
RULE 0 pains_c_keto_keto_gamma
RULE 0 pains_c_quinone_B
RULE 0 pains_c_het_6_pyridone_OH
RULE 0 pains_c_hzone_naphth_A
RULE 0 pains_c_thio_ester_A
RULE 0 pains_c_ene_misc_A
RULE 0 pains_c_cyano_pyridone_D
RULE 0 pains_c_het_65_Db
RULE 0 pains_c_het_666_A
RULE 0 pains_c_diazox_sulfon_B
RULE 0 pains_c_anil_NH_alk_A
RULE 0 pains_c_sulfonamide_C
RULE 0 pains_c_het_thio_N_55
RULE 0 pains_c_keto_keto_beta_D
RULE 0 pains_c_ene_rhod_H
RULE 0 pains_c_imine_ene_A
RULE 0 pains_c_het_thio_656a
RULE 0 pains_c_pyrrole_D
RULE 0 pains_c_pyrrole_E
RULE 0 pains_c_thio_urea_G
RULE 0 pains_c_anisol_A
RULE 0 pains_c_pyrrole_F
RULE 0 pains_c_dhp_amino_CN_D
RULE 0 pains_c_thiazole_amine_A
RULE 0 pains_c_het_6_imidate_A
RULE 0 pains_c_anil_OC_no_alk_B
RULE 0 pains_c_styrene_C
RULE 0 pains_c_azulene
RULE 0 pains_c_furan_acid_A
RULE 0 pains_c_cyano_pyridone_E
RULE 0 pains_c_anil_alk_thio
RULE 0 pains_c_anil_di_alk_I
RULE 0 pains_c_het_thio_6_furan
RULE 0 pains_c_anil_di_alk_ene_B
RULE 0 pains_c_imine_one_B
RULE 0 pains_c_anil_OC_alk_A
RULE 0 pains_c_ene_five_het_J
RULE 0 pains_c_pyrrole_G
RULE 0 pains_c_ene_five_het_K
RULE 0 pains_c_cyano_ene_amine_B
RULE 0 pains_c_thio_ester_B
RULE 0 pains_c_ene_five_het_L
RULE 0 pains_c_hzone_thiophene_B
RULE 0 pains_c_dhp_amino_CN_E
RULE 0 pains_c_het_5_B
RULE 0 pains_c_imine_imine_B
RULE 0 pains_c_thiazole_amine_B
RULE 0 pains_c_imine_ene_one_A
RULE 0 pains_c_diazox_A
RULE 0 pains_c_ene_one_A
RULE 0 pains_c_anil_OC_no_alk_C
RULE 0 pains_c_thiazol_SC_A
RULE 0 pains_c_het_666_B
RULE 0 pains_c_furan_A
RULE 0 pains_c_colchicine_A
RULE 0 pains_c_thiophene_C
RULE 0 pains_c_anil_OC_alk_B
RULE 0 pains_c_het_thio_66_A
RULE 0 pains_c_rhod_sat_B
RULE 0 pains_c_ene_rhod_I
RULE 0 pains_c_keto_thiophene
RULE 0 pains_c_imine_imine_C
RULE 0 pains_c_het_65_pyridone_A
RULE 0 pains_c_thiazole_amine_C
RULE 0 pains_c_het_thio_pyr_A
RULE 0 pains_c_melamine_A
RULE 0 pains_c_anil_NH_alk_B
RULE 0 pains_c_rhod_sat_C
RULE 0 pains_c_thiophene_amino_D
RULE 0 pains_c_anil_OC_alk_C
RULE 0 pains_c_het_thio_65_A
RULE 0 pains_c_het_thio_656b
RULE 0 pains_c_thiazole_amine_D
RULE 0 pains_c_thio_urea_H
RULE 0 pains_c_cyano_pyridone_F
RULE 0 pains_c_rhod_sat_D
RULE 0 pains_c_ene_rhod_J
RULE 0 pains_c_imine_phenol_A
RULE 0 pains_c_thio_carbonate_B
RULE 0 pains_c_het_thio_N_5A
RULE 0 pains_c_het_thio_N_65A
RULE 0 pains_c_anil_di_alk_J
RULE 0 pains_c_pyrrole_H
RULE 0 pains_c_ene_cyano_D
RULE 0 pains_c_cyano_cyano_B
RULE 0 pains_c_ene_five_het_M
RULE 0 pains_c_cyano_ene_amine_C
RULE 0 pains_c_thio_urea_I
RULE 0 pains_c_dhp_amino_CN_F
RULE 0 pains_c_anthranil_acid_B
RULE 0 pains_c_diazox_B
RULE 0 pains_c_thio_aldehyd_A
RULE 0 pains_c_thio_amide_B
RULE 0 pains_c_imidazole_B
RULE 0 pains_c_thiazole_amine_E
RULE 0 pains_c_thiazole_amine_F
RULE 0 pains_c_thio_ester_C
RULE 0 pains_c_ene_one_B
RULE 0 pains_c_quinone_C
RULE 0 pains_c_keto_naphthol_A
RULE 0 pains_c_thio_amide_C
RULE 0 pains_c_phthalimide_misc
RULE 0 pains_c_sulfonamide_D
RULE 0 pains_c_anil_NH_alk_C
RULE 0 pains_c_het_65_E
RULE 0 pains_c_hzide_naphth
RULE 0 pains_c_anisol_B
RULE 0 pains_c_thio_carbam_ene
RULE 0 pains_c_thio_amide_D
RULE 0 pains_c_het_65_Da
RULE 0 pains_c_thiophene_D
RULE 0 pains_c_het_thio_6_ene
RULE 0 pains_c_cyano_keto_A
RULE 0 pains_c_anthranil_acid_C
RULE 0 pains_c_naphth_amino_C
RULE 0 pains_c_naphth_amino_D
RULE 0 pains_c_thiazole_amine_G
RULE 0 pains_c_het_66_B
RULE 0 pains_c_coumarin_A
RULE 0 pains_c_anthranil_acid_D
RULE 0 pains_c_het_66_C
RULE 0 pains_c_thiophene_amino_E
RULE 0 pains_c_het_6666_A
RULE 0 pains_c_sulfonamide_E
RULE 0 pains_c_anil_di_alk_K
RULE 0 pains_c_het_5_C
RULE 0 pains_c_ene_six_het_B
RULE 0 pains_c_steroid_A
RULE 0 pains_c_het_565_A
RULE 0 pains_c_thio_imine_ium
RULE 0 pains_c_anthranil_acid_E
RULE 0 pains_c_hzone_furan_B
RULE 0 pains_c_thiophene_E
RULE 0 pains_c_ene_misc_B
RULE 0 pains_c_het_thio_5_B
RULE 0 pains_c_thiophene_amino_F
RULE 0 pains_c_anil_OC_alk_D
RULE 0 pains_c_tert_butyl_A
RULE 0 pains_c_thio_urea_J
RULE 0 pains_c_het_thio_65_B
RULE 0 pains_c_coumarin_B
RULE 0 pains_c_thio_urea_K
RULE 0 pains_c_thiophene_amino_G
RULE 0 pains_c_anil_NH_alk_D
RULE 0 pains_c_het_thio_5_C
RULE 0 pains_c_thio_keto_het
RULE 0 pains_c_het_thio_N_5B
RULE 0 pains_c_quinone_D
RULE 0 pains_c_anil_di_alk_furan_B
RULE 0 pains_c_ene_six_het_C
RULE 0 pains_c_het_55_A
RULE 0 pains_c_het_thio_65_C
RULE 0 pains_c_hydroquin_A
RULE 0 pains_c_anthranil_acid_F
RULE 0 pains_c_pyrrole_I
RULE 0 pains_c_thiophene_amino_H
RULE 0 pains_c_imine_one_fives_C
RULE 0 pains_c_keto_phenone_zone_A
RULE 0 pains_c_dyes7A
RULE 0 pains_c_het_pyridiniums_B
RULE 0 pains_c_het_5_D
RULE 0 pains_c_thiazole_amine_H
RULE 0 pains_c_thiazole_amine_I
RULE 0 pains_c_het_thio_N_5C
RULE 0 pains_c_sulfonamide_F
RULE 0 pains_c_thiazole_amine_J
RULE 0 pains_c_het_65_F
RULE 0 pains_c_keto_keto_beta_E
RULE 0 pains_c_ene_five_one_B
RULE 0 pains_c_keto_keto_beta_zone
RULE 0 pains_c_thio_urea_L
RULE 0 pains_c_het_thio_urea_ene
RULE 0 pains_c_cyano_amino_het_A
RULE 0 pains_c_tetrazole_hzide
RULE 0 pains_c_imine_naphthol_A
RULE 0 pains_c_misc_anisole_A
RULE 0 pains_c_het_thio_665
RULE 0 pains_c_anil_di_alk_L
RULE 0 pains_c_colchicine_B
RULE 0 pains_c_misc_aminoacid_A
RULE 0 pains_c_imidazole_amino_A
RULE 0 pains_c_phenol_sulfite_A
RULE 0 pains_c_het_66_D
RULE 0 pains_c_misc_anisole_B
RULE 0 pains_c_tetrazole_A
RULE 0 pains_c_het_65_G
RULE 0 pains_c_misc_trityl_A
RULE 0 pains_c_misc_pyridine_OC
RULE 0 pains_c_het_6_hydropyridone
RULE 0 pains_c_misc_stilbene
RULE 0 pains_c_misc_imidazole
RULE 0 pains_c_anil_NH_no_alk_A
RULE 0 pains_c_het_6_imidate_B
RULE 0 pains_c_anil_alk_B
RULE 0 pains_c_styrene_anil_A
RULE 0 pains_c_misc_aminal_acid
RULE 0 pains_c_anil_no_alk_D
RULE 0 pains_c_anil_alk_C
RULE 0 pains_c_misc_anisole_C
RULE 0 pains_c_het_465_misc
RULE 0 pains_c_anthranil_acid_G
RULE 0 pains_c_anil_di_alk_M
RULE 0 pains_c_anthranil_acid_H
RULE 0 pains_c_thio_urea_M
RULE 0 pains_c_thiazole_amine_K
RULE 0 pains_c_het_thio_5_imine_A
RULE 0 pains_c_thio_amide_E
RULE 0 pains_c_het_thio_676_B
RULE 0 pains_c_sulfonamide_G
RULE 0 pains_c_thio_thiomorph_Z
RULE 0 pains_c_naphth_ene_one_A
RULE 0 pains_c_naphth_ene_one_B
RULE 0 pains_c_amino_acridine_Ac
RULE 0 pains_c_keto_phenone_B
RULE 0 pains_c_hzone_acid_A
RULE 0 pains_c_sulfonamide_H
RULE 0 pains_c_het_565_indole
RULE 0 pains_c_pyrrole_J
RULE 0 pains_c_pyrazole_amino_B
RULE 0 pains_c_pyrrole_K
RULE 0 pains_c_anthranil_acid_I
RULE 0 pains_c_thio_amide_F
RULE 0 pains_c_ene_one_C
RULE 0 pains_c_het_65_H
RULE 0 pains_c_cyano_imine_D
RULE 0 pains_c_cyano_misc_A
RULE 0 pains_c_ene_misc_C
RULE 0 pains_c_het_66_E
RULE 0 pains_c_keto_keto_beta_F
RULE 0 pains_c_misc_naphthimidazole
RULE 0 pains_c_naphth_ene_one_C
RULE 0 pains_c_keto_phenone_C
RULE 0 pains_c_coumarin_C
RULE 0 pains_c_thio_est_cyano_A
RULE 0 pains_c_het_65_imidazole
RULE 0 pains_c_anthranil_acid_J
RULE 0 pains_c_colchicine_het
RULE 0 pains_c_ene_misc_D
RULE 0 pains_c_indole_3yl_alk_B
RULE 0 pains_c_anil_OH_no_alk_A
RULE 0 pains_c_thiazole_amine_L
RULE 0 pains_c_pyrazole_amino_A
RULE 0 pains_c_het_thio_N_5D
RULE 0 pains_c_anil_alk_indane
RULE 0 pains_c_anil_di_alk_N
RULE 0 pains_c_het_666_C
RULE 0 pains_c_ene_one_D
RULE 0 pains_c_anil_di_alk_indol
RULE 0 pains_c_anil_no_alk_indol_A
RULE 0 pains_c_dhp_amino_CN_G
RULE 0 pains_c_anil_di_alk_dhp
RULE 0 pains_c_anthranil_amide_A
RULE 0 pains_c_hzone_anthran_Z
RULE 0 pains_c_ene_one_amide_A
RULE 0 pains_c_het_76_A
RULE 0 pains_c_thio_urea_N
RULE 0 pains_c_anil_di_alk_coum
RULE 0 pains_c_ene_one_amide_B
RULE 0 pains_c_het_thio_656c
RULE 0 pains_c_het_5_ene
RULE 0 pains_c_thio_imide_A
RULE 0 pains_c_dhp_amidine_A
RULE 0 pains_c_thio_urea_O
RULE 0 pains_c_anil_di_alk_O
RULE 0 pains_c_thio_urea_P
RULE 0 pains_c_het_pyraz_misc
RULE 0 pains_c_diazox_C
RULE 0 pains_c_diazox_D
RULE 0 pains_c_misc_cyclopropane
RULE 0 pains_c_imine_ene_one_B
RULE 0 pains_c_coumarin_D
RULE 0 pains_c_misc_furan_A
RULE 0 pains_c_rhod_sat_E
RULE 0 pains_c_rhod_sat_imine_A
RULE 0 pains_c_rhod_sat_F
RULE 0 pains_c_het_thio_5_imine_B
RULE 0 pains_c_het_thio_5_imine_C
RULE 0 pains_c_ene_five_het_N
RULE 0 pains_c_thio_carbam_A
RULE 0 pains_c_misc_anilide_A
RULE 0 pains_c_misc_anilide_B
RULE 0 pains_c_mannich_B
RULE 0 pains_c_mannich_catechol_A
RULE 0 pains_c_anil_alk_D
RULE 0 pains_c_het_65_I
RULE 0 pains_c_misc_urea_A
RULE 0 pains_c_imidazole_C
RULE 0 pains_c_styrene_imidazole_A
RULE 0 pains_c_thiazole_amine_M
RULE 0 pains_c_misc_pyrrole_thiaz
RULE 0 pains_c_pyrrole_L
RULE 0 pains_c_het_thio_65_D
RULE 0 pains_c_ene_misc_E
RULE 0 pains_c_thio_cyano_A
RULE 0 pains_c_cyano_amino_het_B
RULE 0 pains_c_cyano_pyridone_G
RULE 0 pains_c_het_65_J
RULE 0 pains_c_ene_one_yne_A
RULE 0 pains_c_anil_OH_no_alk_B
RULE 0 pains_c_hzone_acyl_misc_A
RULE 0 pains_c_thiophene_F
RULE 0 pains_c_anil_OC_alk_E
RULE 0 pains_c_anil_OC_alk_F
RULE 0 pains_c_het_65_K
RULE 0 pains_c_het_65_L
RULE 0 pains_c_coumarin_E
RULE 0 pains_c_coumarin_F
RULE 0 pains_c_coumarin_G
RULE 0 pains_c_coumarin_H
RULE 0 pains_c_het_thio_67_A
RULE 0 pains_c_sulfonamide_I
RULE 0 pains_c_het_65_mannich
RULE 0 pains_c_anil_alk_A
RULE 0 pains_c_het_5_inium
RULE 0 pains_c_anil_di_alk_P
RULE 0 pains_c_thio_urea_Q
RULE 0 pains_c_thio_pyridine_A
RULE 0 pains_c_melamine_B
RULE 0 pains_c_misc_phthal_thio_N
RULE 0 pains_c_hzone_acyl_misc_B
RULE 0 pains_c_tert_butyl_B
RULE 0 pains_c_diazox_E
RULE 0 pains_c_anil_NH_no_alk_B
RULE 0 pains_c_anil_no_alk_A
RULE 0 pains_c_anil_no_alk_B
RULE 0 pains_c_thio_ene_amine_A
RULE 0 pains_c_het_55_B
RULE 0 pains_c_cyanamide_A
RULE 0 pains_c_ene_one_one_A
RULE 0 pains_c_ene_six_het_D
RULE 0 pains_c_ene_cyano_E
RULE 0 pains_c_ene_cyano_F
RULE 0 pains_c_hzone_furan_C
RULE 0 pains_c_anil_no_alk_C
RULE 0 pains_c_hzone_acid_D
RULE 0 pains_c_hzone_furan_E
RULE 0 pains_c_het_6_pyridone_NH2
RULE 0 pains_c_imine_one_fives_D
RULE 0 pains_c_pyrrole_M
RULE 0 pains_c_pyrrole_N
RULE 0 pains_c_pyrrole_O
RULE 0 pains_c_ene_cyano_G
RULE 0 pains_c_sulfonamide_J
RULE 0 pains_c_misc_pyrrole_benz
RULE 0 pains_c_thio_urea_R
RULE 0 pains_c_ene_one_one_B
RULE 0 pains_c_dhp_amino_CN_H
RULE 0 pains_c_het_66_anisole
RULE 0 pains_c_thiazole_amine_N
RULE 0 pains_c_het_pyridiniums_C
RULE 0 pains_c_het_5_E