In order to use the OpenEye Python toolkits, a compatible version of Python must be installed. Instructions on installing Python are given in this document.

Linux installation also requires the zlib and libcairo libraries be available. These are usually available on Desktop Linux installations by default, but may not be available on Linux server installations.

Below are the different Python versions supported for various platforms.


The following platforms and Python versions are supported with one single build Linux package:

RHEL8, RHEL9, Ubuntu 20.04, Ubuntu 22.04

  • 3.[9-11]


For macOS, packages are built for both intel and arm64 versions.

  • 3.[9-11] on macOS 12-13 x64 and arm64


On Windows, packages are built for specific Python versions.

  • 3.9 (x64)

  • 3.10 (x64)


VSRUNTIME140.dll and MSVCP140.dll are dependencies of OpenEye Windows dlls. The recommended Anaconda Python provides these.

GPU Prerequisites