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In order to use the OpenEye Python toolkits, a compatible version of Python must be installed. Instructions on installing Python are given in this document.

Python3 is binary compatible between minor versions on Linux and OSX, so the “python3” distribution works in for Python 3.4 and higher. On Windows, 3.5 and 3.6 are supported. Below are the different Python versions supported for various platforms.

Linux installation also requires the zlib and libcairo libraries be available. These are usually available on Desktop Linux installations by default, but may not be available on Linux server installations.


  • RHEL6, RHEL7, Ubuntu 14.04, Ubuntu 16.04
    • 3.[4-6] (x64)


  • OS X 10.10 - 10.13
    • 3.[4-6] (x64)


  • 3.5 (x86 and x64)
  • 3.6 (x86 and x64)


VSRUNTIME140.dll and MSVCP140.dll are dependencies of OpenEye Windows dlls. The recommended Anaconda Python provides these.