Liability Quantification Across CDRs - AbXtract

Category Paths

Follow one of these paths in the Orion user interface, to find the floe.

• Solution-based/Biologics/Antibody Design

• Role-based/Bioinformatician

• Role-based/Biologist

• Product-based/AbXtract

Description

Quantify sequence-based liabilities across all CDRs. More rapid version relative to previous

Promoted Parameters

Title in user interface (promoted name)

Key Liability Parameters

Polyspecificity Liabilities (liability_choices_poly): polyspecificity liabilities to quantify

• Type: string

• Default: [‘Three Consecutive Aromatics - Polyspecificity’, ‘RR - Polyspecificity’, ‘VG - Polyspecificity’, ‘VV - Polyspecificity’, ‘WW - Polyspecificity’, ‘GGG - Polyspecificity’, ‘WXW - Polyspecificity’, ‘YY - Polyspecificity’]

• Choices: [‘Three Consecutive Aromatics - Polyspecificity’, ‘RR - Polyspecificity’, ‘VG - Polyspecificity’, ‘VV - Polyspecificity’, ‘YY - Polyspecificity’, ‘WW - Polyspecificity’, ‘GGG - Polyspecificity’, ‘WXW - Polyspecificity’]

Deamidation Liabilities (liability_choices_deam): deamidation liabilities to quantify

• Type: string

• Default: [‘NG - Deamidation’, ‘NS - Deamidation’, ‘NT - Deamidation’, ‘NN - Deamidation’, ‘GNF - Deamidation’, ‘GNY - Deamidation’, ‘GNT - Deamidation’, ‘GNG - Deamidation’, ‘QG - Glutamine Deamidation’]

• Choices: [‘N[GSTN] - Deamidation’, ‘NG - Deamidation’, ‘NS - Deamidation’, ‘NT - Deamidation’, ‘NN - Deamidation’, ‘GN[FYTG] - Deamidation’, ‘GNF - Deamidation’, ‘GNY - Deamidation’, ‘GNT - Deamidation’, ‘GNG - Deamidation’, ‘QG - Glutamine Deamidation’]

Glycosylation Liabilities (liability_choices_glyc): glycosylation liabilities to quantify

• Type: string

• Default: [‘NXT/S - Glycosylation’]

• Choices: [‘NXT/S - Glycosylation’, ‘NXT - Glycosylation’, ‘NXS - Glycosylation’]

Hydrolysis Liabilities (liability_choices_hydrolysis): hydrolysis liabilities to quantify

• Type: string

• Default: [‘DP - Hydrolysis’]

• Choices: [‘DP - Hydrolysis’]

Isomerization Liabilities (liability_choices_iso): isomerization liabilities to quantify

• Type: string

• Default: [‘DG - Isomerization’, ‘DS - Isomerization’, ‘DD - Isomerization’]

• Choices: [‘D[GSD] - Isomerization’, ‘DG - Isomerization’, ‘DS - Isomerization’, ‘DD - Isomerization’]

Biophysical Liabilities (liability_choices_charge): Net charge or hydropathy liabilities to quantify

• Type: string

• Default: [‘Charge (>1)’]

• Choices: [‘Charge (>-1)’, ‘Charge (>0)’, ‘Charge (>1)’, ‘Charge (>2)’, ‘Charge (>3)’, ‘Charge (>4)’, ‘Parker Hydropathy (<0.0)’, ‘Parker Hydropathy (<-0.1)’, ‘Parker Hydropathy (<-0.2)’, ‘Parker Hydropathy (<-0.3)’, ‘Parker Hydropathy (<-0.4)’, ‘Parker Hydropathy (<-0.5)’, ‘Parker Hydropathy (<-0.6)’, ‘Parker Hydropathy (<-0.7)’, ‘Parker Hydropathy (<-0.8)’, ‘Parker Hydropathy (<-0.9)’, ‘Parker Hydropathy (<-1.0)’, ‘Parker Hydropathy (<-2.0)’, ‘Parker Hydropathy (<-3.0)’, ‘Parker Hydropathy (<-4.0)’, ‘Parker Hydropathy (<-5.0)’]

Cysteine Liabilities (liability_choices_cysteine): cysteine-based liabilities to quantify

• Type: string

• Default: [‘Unpaired Cysteine’]

• Choices: [‘Unpaired Cysteine’, ‘Any Cysteine’]