AI Fold Floes Release Notes

v0.2.6 April 2026

General Notice

• This package is built using OpenEye-orionplatform==6.8.3, OpenEye-toolkits==2025.2.2, and OpenEye-Snowball==0.31.4.

Documentation Updates

• Documentation has been added to guide the user on the Protein Sequence to AI Folded Structure Ligand Affinities Floe.

• Documentation has been added to guide the user to create their own distributed MSA databases on Orion.

• Documentation has been added to guide the user on different MSA databases that can be used with protein folding.

Floe Updates

• Support has been added to supply template structures to Boltz to guide the folding process.

• General error handling has been updated.

• Minor typos have been fixed.

• Input form examples are no longer quoted to avoid confusion with the actual input forms.

• Output from the Protein Sequence to AI Folded Structure Ligand Affinities Floe now have unique names using a count incrementing method.