The PICTO SMARTS window (populating the right side of PICTO) contains a basic 2D sketching environment, a SMARTS query entry mechanism, a textbox displaying the SMARTS pattern, and a dropdown for matches. Once a valid SMARTS query is entered, it will be applied to the molecule in the main sketcher and the first match will be highlighted. The matches can be cycled through using the dropdown.

A basic overview of a SMARTS query can be seen in Figure: SMARTS